IFN1@ Cluster
gene cluster GIFtS: 15
GCID: GC09U990039
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interferon, type 1, cluster
(Previous symbol: IFNA)
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Aliases
for IFN1@ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Interferon, Type 1, Cluster1 2 | | IFNA1 2 |
Export aliases for IFN1@ gene to outside databases |
Summaries
for IFN1@ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Gene Wiki entry for IFN1@
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Genomic Views
for IFN1@ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IFN1@
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFN1@
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFN1@ |
Genomic Location:
Chromosome:9
Entrez Gene cytogenetic band: 9p22 HGNC cytogenetic band: 9p22GeneLoc information about chromosome 9 |
Proteins
for IFN1@ gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for IFN1@ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for IFN1@ gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
Genatlas biochemistry entry for IFN1@:interferon type I,cluster,26 genes and pseudogenes,expressed by macrophages,involved in antiviralactivities,stimulating oligoadenylate synthetase
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Pathways & Interactions
for IFN1@ gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Cytokines and Inflammatory Response | |
1  BioSystems Pathway for IFN1@
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFN1@
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Drugs & Compounds
for IFN1@ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFN1@
Search CenterWatch for drugs/clinical trials and news about IFN1@
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Transcripts
for IFN1@ gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for IFN1@ gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for IFN1@:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for IFN1@
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IFN1@ | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFN1@ | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFN1@ |
Orthologs
for IFN1@ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for IFN1@ gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ifna5 |
interferon alpha |
-- |
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4 - |
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Paralogs
for IFN1@ gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IFN1@ gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for IFN1@ gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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IFN1@ for disorders About GeneDecksing
20/48  diseases for IFN1@ (see all 48): About MalaCardshuman t-cell leukemia virus type 1 molluscum contagiosum non-hodgkin lymphoma severe acute respiratory syndrome
b-cell lymphomas hepatitis c biliary atresia cutaneous leishmaniasis
systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma hepatitis b
rheumatoid arthritis, association with rheumatoid arthritis multiple sclerosis chronic myeloid leukemia
retinal vasculitis myeloid leukemia viral hepatitis leishmaniasis
10/17 Novoseek disease relationships for IFN1@ gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| virus infection |
64.1 |
13 |
11222729 (1), 11370770 (1), 17065575 (1), 17075576 (1) (see all 11) |
| hepatitis c chronic |
52.4 |
1 |
9303508 (1) |
| autoimmune diseases |
42.4 |
4 |
8590314 (1), 17873860 (1), 17310002 (1), 16210337 (1) |
| hepatitis c |
42.1 |
2 |
15602727 (1), 15622484 (1) |
| hepatitis b chronic |
34.3 |
1 |
9093949 (1) |
| multiple sclerosis |
27.3 |
2 |
11447332 (2) |
| inflammation |
18.4 |
5 |
19209676 (1), 11017101 (1), 19488401 (1), 19120280 (1) |
| psoriasis |
17.8 |
3 |
14962090 (1), 17310002 (1), 19399181 (1) |
| necrosis |
16 |
2 |
12972516 (1), 19769973 (1) |
| infectious disease |
12 |
1 |
11739152 (1) |
Export disorders for IFN1@ gene to outside databases
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Publications
for IFN1@ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for IFN1@ gene, integrated from 9 sources (see all 157):
(articles sorted by number of sources associating them with IFN1@) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms. (PubMed id 15091316)1, 9 Wieczorek S....Gencik M. (2004)
- Respiratory syncytial virus NS1 protein colocalizes wi th mitochondrial antiviral signaling protein MAVS following infection. (PubMed id 22383950)1 Boyapalle S....Mohapatra S. (2012)
- Early activation of p38 mitogen activated protein kin ase is associated with interferon-alpha-induced depression and fatigue. (PubMed id 21356304)1 Felger J.C....Miller A.H. (2011)
- Regulation of IFN response gene activity during infli ximab treatment in rheumatoid arthritis is associated with clinical response to treatment. (PubMed id 20096109)1 van Baarsen L.G....Verweij C.L. (2010)
- Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha. (PubMed id 19800767)1 Bergman R....Karin N. (2009)
- TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. (PubMed id 19124725)1 Richez C....Rifkin I.R. (2009)
- Reciprocal responsiveness to interleukin-12 and inter feron-alpha specifies human CD8+ effector versus central memory T-cell fates. (PubMed id 19299334)1 Ramos H.J....Farrar J.D. (2009)
- Differential regulation of human interferon A gene ex pression by interferon regulatory factors 3 and 7. (PubMed id 19349300)1 GAcnin P....Civas A. (2009)
- Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus. (PubMed id 18240214)1 Niewold T.B....Crow M.K. (2008)
- Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells. (PubMed id 18305050)1 Narayanan K....Makino S. (2008)
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External Searches for IFN1@ gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IFN1@ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing IFN1@ gene
(According to HUGE)
About This Section
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Specialized Databases showing IFN1@ gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for IFN1@ | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for IFN1@ gene:
Search GeneIP for patents involving IFN1@
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IFN1@ gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFN1@ | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFN1@ | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFN1@ | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFN1@ | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFN1@ | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFN1@ |
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| | | | Search Tocris compounds for IFN1@ |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for IFN1@ |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IFN1@ |
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