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IFLTD1 Gene

protein-coding   GIFtS: 41

GC12M025521
intermediate filament tail domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for IFLTD1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ36004 1, 2
Pas1c1 1, 2
Descriptions
intermediate filament tail domain containing 1 2
External Ids
HGNC: 266831
Entrez Gene: 1604922
UniProtKB: Q8N9Z93
Ensembl: ENSG000001529367
Search outside databases for aliases for IFLTD1 gene

Summaries
for IFLTD1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for IFLTD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.1

IFLTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M025521:     (about GC identifiers)

Start:
 25,520,283 bp from pter
End:
 25,597,445 bp from pter
Size:
 77,163 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009714.16  

Proteins
for IFLTD1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: ILFT1_HUMAN, Q8N9Z9 (See protein sequence)
Recommended Name: Intermediate filament tail domain-containing protein 1  
Size: 388 amino acids; 43366 Da
Secondary accessions: Q8IY38
Alternative splicing: 2 isoforms:  Q8N9Z9-1   Q8N9Z9-2   

REFSEQ proteins (4 alternative transcripts): 
NP_001139199.1  NP_001139200.1  NP_001139201.1  NP_689803.2  


ENSEMBL proteins: 
ENSP00000282881 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (IFLTD1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005882 intermediate filament IEA--
About this table

Antibodies for IFLTD1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for IFLTD1

Assays for IFLTD1: 
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Protein Domains/
Families
for IFLTD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR001664 IF
 IPR001322 IF_tail_C


   GeneDecks  IFLTD1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8N9Z9

ProtoNet protein and cluster: Q8N9Z9

UniProtKB/Swiss-Prot: ILFT1_HUMAN, Q8N9Z9
Similarity: Belongs to the intermediate filament family

Gene Function
for IFLTD1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (IFLTD1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_152590

              Applied Biosystems Silencer® siRNAs for IFLTD1

              Sigma-Aldrich siRNA for IFLTD1  
                     Sigma-Aldrich shRNA for IFLTD1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IFLTD1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145727
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145727
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001145727 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001145728

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005198 structural molecule activity IEA--
About this table

Pathways & Interactions
for IFLTD1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for IFLTD1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFLTD1

Transcripts
for IFLTD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (IFLTD1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_152590

              Sigma-Aldrich siRNA for IFLTD1  
                     Sigma-Aldrich shRNA for IFLTD1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_152590  

REFSEQ mRNAs for IFLTD1 gene (4 alternative transcripts): 

NM_001145727.1   NM_001145728.1   NM_001145729.1   NM_152590.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_152590  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145727
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145727
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001145727 

Additional cDNA sequence: 

AK093323.1 AK296816.1 AK302292.1 AK310411.1 BC037957.1 

4 DOTS entries:

DT.100018263  DT.97800122  DT.121138290  DT.121138318 

9 AceView cDNA sequences:

BM563573 BC037957 BP359528 AK093323 AX748055 AI632491 NM_152590 AA904847 
CD696835 

highest scoring ESTs for IFLTD1:

AI632491 AK093323 BC037957 BM563573 AA904847 NM_152590 AX748055 CR748411 DB029156 DB031363 

Unigene Cluster for IFLTD1:

Intermediate filament tail domain containing 1
Hs.44647  [show with all ESTs]
Unigene Representative Sequence: NM_001145728


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IFLTD1

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:              -                                                               
SP2:                          -                                                   

About this scheme

ECgene alternative splicing isoforms for IFLTD1

1 Ensembl transcript including schematic representation:
ENST00000282881  

Expression
for IFLTD1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFLTD1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFLTD1

1 / 2 / 3

2 probe-sets matching IFLTD1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

68453_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AI632491 0.80 1.00 0.91 1

1552865_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGAGGGTGAA

SOURCE GeneReport for Unigene cluster: Hs.44647

Orthologs
for IFLTD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for IFLTD1 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 IFLTD11   -- intermediate filament tail domain containing 1 76.89(n)
67.4(a)		 477668  XM_534861.2  XP_534861.2 
chimpanzee
(Pan troglodytes)		 IFLTD11   -- intermediate filament tail domain containing 1 98.71(n)
98.07(a)		 465350  XM_520804.2  XP_520804.2 
cow
(Bos taurus)		 IFLTD11   -- intermediate filament tail domain containing 1 75.69(n)
62.96(a)		 518130  XM_596314.3  XP_596314.3 
rat
(Rattus norvegicus)		 Ifltd11   -- intermediate filament tail domain containing 1 65.92(n)
56.9(a)		 500362  XM_575719.2  XP_575719.2 
mouse
(Mus musculus)		 Ifltd11, 5 6 (71.30 cM)5
 intermediate filament tail domain containing 11, 5 67.39(n)1
57.61(a)1		 740711  NM_028742.21  NP_083018.11 
 AI4823005  AK0166415  (see all 13)
About this table        Species with no ortholog for IFLTD1

ENSEMBL Gene Tree for IFLTD1

Paralogs
for IFLTD1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for IFLTD1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/577 NCBI SNPs in IFLTD1 are shown (see all 577 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 198)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs16120391,2
A,C,F,H,O25598258(-) ATTACA/GTGTTA 1 -- ng318Minor allele frequency- N:0.00EU EA WA NA 630
rs14795001,2
A,C,F,H,O25563026(-) CCAGGT/ACTCGG 1 T/S mis1 ese310Minor allele frequency- A:0.25MN EU EA WA NA 1082
rs8290471,2
A,C,F,H,O25597401(-) TTGTCT/CGACAT 1 -- ut51 ese312Minor allele frequency- C:0.33NS NA EU EA WA 666
rs8290451,2
A,C,F,H25598971(-) ttgtaG/Atctat 1 -- ng314Minor allele frequency- A:0.35EU EA WA 420
rs8290461,2
A,F,H25598918(-) gaacaT/Ctattt 1 -- ng314Minor allele frequency- C:0.33EU EA WA 420
--
rs8290441,2
A,C25599064(-) tggtcC/Ttgaac 1 -- ng310--------
rs347327861,2
C,F25564147(+) AGCTGT/CAGATG 1 A/T mis15Minor allele frequency- C:0.01NA EU EA WA 494
rs354502031,2
C,F25564222(+) GTCAGC/TATCTA 1 A/T mis15Minor allele frequency- T:0.02NA EU EA WA 492
rs340745221,2
C,F25564144(+) TGTAGC/TTGTAG 1 A/T mis15Minor allele frequency- T:0.01NA EU EA WA 492
rs343268301,2
C,F25564212(+) TAAATT/CCAACG 1 G/E mis15Minor allele frequency- C:0.02NA EU EA WA 494
About this table

HapMap Linkage Disequilibrium images for IFLTD1 (up to first 250kb)

Disorders & Mutations
for IFLTD1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for IFLTD1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for IFLTD1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for IFLTD1 gene:

Search for IFLTD1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IFLTD1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 160492 HGNC: 26683 AceView: FLJ36004 Ensembl:ENSG00000152936 euGenes: HUgn160492
ECgene: IFLTD1 H-InvDB: IFLTD1

Other Databases showing IFLTD1

(According to HUGE)
About This Section

   --

Specialized Databases showing IFLTD1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for IFLTD1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for IFLTD1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFLTD1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFLTD1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for IFLTD1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFLTD1 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for IFLTD1

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