IFLTD1 Gene
protein-coding GIFtS : 46
GCID: GC12 M025564
intermediate filament tail domain containing 1
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Aliasesfor IFLTD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Intermediate Filament Tail Domain Containing 1 1 2 FLJ360041 Pas1c11 PAS1C12 Intermediate Filament Tail Domain-Containing Protein 12
Export aliases for IFLTD1 gene to outside databases Previous GC identifers: GC12M025521 GC12M025629 GC12M025400
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Summariesfor IFLTD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor IFLTD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009714.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IFLTD1 gene promoter: Nkx3-1 v2 Nkx3-1 Nkx3-1 v3 Nkx3-1 v1 Other transcription factors Search SABiosciences Chromatin IP Primers for IFLTD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFLTD1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p12.1 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.1 IFLTD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M025564: view genomic region
(about GC identifiers )
Start:
25,562,241 bp from pter
End:
25,801,513 bp from pter
Size:
239,273 bases
Orientation:
minus strand
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Proteinsfor IFLTD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ILFT1_HUMAN, Q8N9Z9 (See
protein sequence )Recommended Name: Intermediate filament tail domain-containing protein 1 Size : 388 amino acids; 43408 Da
Secondary accessions : B4DL27 B4DY70 Q8IY38Alternative splicing : 5 isoforms : Q8N9Z9-1 Q8N9Z9-2 Q8N9Z9-3 Q8N9Z9-4 Q8N9Z9-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IFLTD1: NX_Q8N9Z9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N9Z9 IFLTD1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (5 alternative transcripts):
NP_001139199.1 NP_001139200.1 NP_001139201.1 NP_001243195.1 NP_689803.2 ENSEMBL proteins: ENSP00000438645 ENSP00000282881 ENSP00000443132 ENSP00000407353 ENSP00000407043 ENSP00000393150 ENSP00000438160 ENSP00000443596 ENSP00000442871 ENSP00000445242 ENSP00000443387 Human Recombinant Protein Products for IFLTD1: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
IFLTD1 for ontologies About GeneDecksing IFLTD1 Antibody Products: Assay Products for IFLTD1:
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Protein
Domains / Familiesfor IFLTD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IFLTD1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N9Z9 ProtoNet protein and cluster: Q8N9Z9
UniProtKB/Swiss-Prot: ILFT1_HUMAN, Q8N9Z9 Similarity : Belongs to the intermediate filament family
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Functionfor IFLTD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005198 structural molecule activity
IEA --
IFLTD1 for ontologies About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for IFLTD1 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): IFLTD1 (NM_001145727 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFLTD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFLTD1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFLTD1
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Pathways & Interactionsfor IFLTD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFLTD1 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008283 cell proliferation
IEA --
IFLTD1 for ontologies About GeneDecksing
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Drugs & Compoundsfor IFLTD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IFLTD1 Search CenterWatch for drugs/clinical trials and news about IFLTD1 / ILFT1
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Transcriptsfor IFLTD1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IFLTD1 gene (5 alternative transcripts): NM_001145727.2 NM_001145728.2 NM_001145729.1 NM_001256266.1 NM_152590.3 Unigene Cluster for IFLTD1:
Intermediate filament tail domain containing 1 Hs.44647 [show with all ESTs ] Unigene Representative Sequence: NM_001145727 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000543629 ENST00000282881 (uc010sji.1 uc001rgs.2 ) ENST00000539744 (uc001rgt.1 )ENST00000458174 ENST00000445693 (uc010sjj.2 ) ENST00000413632 (uc009zjc.2 )ENST00000539523 ENST00000545543 ENST00000538178 ENST00000540106 ENST00000542224 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): IFLTD1 (NM_001145727 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFLTD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFLTD1
Additional cDNA sequence: AK093323.1 AK296816.1 AK302292.1 AK310411.1 BC037957.1
5 DOTS entries : DT.100018263 DT.97800122
DT.121138290 DT.97822251 DT.121138318 9 AceView cDNA sequences :
AI632491 AK093323 BP359528 BM563573 NM_152590 BC037957 AX748055 AA904847 CD696835 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for IFLTD1 About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b SP1 :     -                       SP2 :         -                  
ECgene alternative splicing isoforms for IFLTD1
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Expression for IFLTD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IFLTD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGAGGGTGAAAbout this image IFLTD1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See IFLTD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IFLTD1 SOURCE GeneReport for Unigene cluster: Hs.44647 SABiosciences Custom PCR Arrays for IFLTD1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFLTD1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IFLTD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFLTD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFLTD1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFLTD1
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Orthologsfor IFLTD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IFLTD1 gene from 2/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for IFLTD1 (if available)TreeFam Gene Tree for IFLTD1 (if available)
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Paralogsfor IFLTD1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor IFLTD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IFLTD1 (25562241 - 25801513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 9 variations for IFLTD1 6 CNVs : 66164 2974 101459 49036 86272 49035 2 Indels : 24985 10688 1 Inversion : 59706
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFLTD1
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Disorders
/ Diseasesfor IFLTD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IFLTD1 for disorders About GeneDecksing 2 diseases for IFLTD1 : About MalaCards lung adenoma adenoma 1 disease from the University of Copenhagen DISEASES database for IFLTD1 :Lung adenoma Human Genome Epidemiology (HuGE) Navigator: IFLTD1 (1 document)Export disorders for IFLTD1 gene to outside databases
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Publicationsfor IFLTD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IFLTD1 gene integrated from 9 sources : (articles sorted by number of sources associating them with IFLTD1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 2 Scherer S.E.... Gibbs R.A. (2006) Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. (PubMed id 15688036) 1 Wang M....You M. (2005) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for IFLTD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IFLTD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IFLTD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IFLTD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IFLTD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IFLTD1 gene: Search GeneIP for patents involving IFLTD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IFLTD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IFLTD1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IFLTD1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFLTD1 OriGene Protein Over-expression Lysate for IFLTD1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IFLTD1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFLTD1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IFLTD1 OriGene Custom Protein Services for IFLTD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFLTD1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFLTD1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFLTD1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IFLTD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFLTD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFLTD1
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IFLTD1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFLTD1
ThermoFisher Antibodies for IFLTD1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFLTD1
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