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IFITM5 Gene

protein-coding   GIFtS: 37

GC11M000291
interferon induced transmembrane protein 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BRIL 1, 2
Hrmp1 1, 2
fragilis4 1, 2
Descriptions
interferon induced transmembrane protein 5 2
External Ids
HGNC: 166441
Entrez Gene: 3877332
UniProtKB: A6NNB33
Ensembl: ENSG000002060137
Search outside databases for aliases for IFITM5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFITM5 gene  

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000291:     (about GC identifiers)

Start:
288,203 bp from pter
End:
289,526 bp from pter
Size:
1,324 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_035113.6  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFM5_HUMAN, A6NNB3 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 5  
Size: 132 amino acids; 14378 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

REFSEQ proteins: NP_001020466.1  

ENSEMBL proteins: 
ENSP00000372059 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for IFITM5: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for IFITM5

Assays for IFITM5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR007593 Interferon-induced_TM_protein


   GeneDecks  IFITM5 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A6NNB3

ProtoNet protein and cluster: A6NNB3

UniProtKB/Swiss-Prot: IFM5_HUMAN, A6NNB3
Similarity: Belongs to the CD225 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFITM5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001025295

              Applied Biosystems Silencer® siRNAs for IFITM5

              Sigma-Aldrich siRNA for IFITM5  
                     Sigma-Aldrich shRNA for IFITM5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001025295
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001025295
                                 untagged cDNA clone in CMV expression vector: NM_001025295 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001025295

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0009607 response to biotic stimulus IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFITM5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFITM5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001025295

              Sigma-Aldrich siRNA for IFITM5  
                     Sigma-Aldrich shRNA for IFITM5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001025295  

REFSEQ mRNAs for IFITM5 gene: 

NM_001025295.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001025295  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001025295
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001025295
                                 untagged cDNA clone in CMV expression vector: NM_001025295 

Additional cDNA sequence: 

BC127697.1 BC127698.1 BC150562.1 BC150563.1 

1 DOTS entry:

DT.40120733 

3 AceView cDNA sequences:

AA460254 BQ574249 AA463818 

highest scoring ESTs for IFITM5:

AA463818 AA460254 BQ574249 CR747200 DY654432 NM_001025295 

Unigene Cluster for IFITM5:

Interferon induced transmembrane protein 5
Hs.443469  [show with all ESTs]
Unigene Representative Sequence: NM_001025295


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000382614  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IFITM5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFITM5

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GGCACCTAAG

SOURCE GeneReport for Unigene cluster: Hs.443469
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for IFITM5 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
IFITM51   -- interferon induced transmembrane protein 5 79.06(n)
74.38(a)
606890  XM_843371.1  XP_848464.1 
chimpanzee
(Pan troglodytes)
IFITM51   -- interferon induced transmembrane protein 5 98.48(n)
99.24(a)
450915  XM_508189.2  XP_508189.2 
mouse
(Mus musculus)
Ifitm51, 5 75
interferon induced transmembrane protein 51, 5 81.06(n)1
79.55(a)1
738351  NM_053088.21  NP_444318.11 
 AJ0097815  AK0033635  (see all 10)
chicken
(Gallus gallus)
IFITM51   -- interferon induced transmembrane protein 5 66.67(n)
59.06(a)
422992  XM_420924.2  XP_420924.1 
zebrafish
(Danio rerio)
570924022   --   -- 73.5(n)  57092402 
About this table        Species with no ortholog for IFITM5

ENSEMBL Gene Tree for IFITM5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for IFITM5 gene
IFITM12  ENSG000001880822  IFITM32  IFITM22  IFITM8P2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/23 NCBI SNPs in IFITM5 are shown (see all 23 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs71118031,2
A,C,F,H290364(-) CTTTgG/Agggga 1 -- ng314Minor allele frequency- A:0.50EU EA WA 420
rs22937431,2
C,F,H288224(+) TTAATC/TGTGGA 1 -- ut31 ese35Minor allele frequency- T:0.04EA EU WA 1908
rs38176401,2
C,F,H287970(+) GAGATC/TAAAGG 1 -- ng514Minor allele frequency- T:0.26EA EU 1782
--
rs71059701,2
A,C290134(-) GGGGTC/TCCCCT 1 -- ng31 tfbs30--------
rs22937441,2
F,H288316(+) GACCCC/TGGGGT 1 -- ut31 ese35Minor allele frequency- T:0.24EA EU WA 1888
--
rs118239681,2
A,C291301(+) tacgcC/Tgaata 1 -- ng310--------
--
rs118239551,2
A,C291298(+) tcctaC/Tgccga 1 -- ng310--------
--
rs71121671,2
A,C290047(-) CAGCCA/GCCCTC 1 -- ng310--------
rs116031421,2
C290228(+) CTCGGC/GTGCCC 1 -- ng310--------
rs22937451,2
A,C288758(+) TCCTCA/GGGGCC 1 -- int10--------
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HapMap Linkage Disequilibrium images for IFITM5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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5 PubMed articles for IFITM5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 387733 HGNC: 16644 AceView: LOC387733 Ensembl:ENSG00000206013 euGenes: HUgn387733
ECgene: IFITM5 H-InvDB: IFITM5
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFITM5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFITM5-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for IFITM5 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFITM5 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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