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Aliases for IFITM3 Gene

Aliases for IFITM3 Gene

  • Interferon Induced Transmembrane Protein 3 2 3 5
  • Interferon-Inducible Protein 1-8U 3 4
  • Dispanin Subfamily A Member 2b 3 4
  • DSPA2b 3 4
  • Interferon Induced Transmembrane Protein 3 (1-8U) 2
  • Interferon-Induced Transmembrane Protein 3 3
  • 1-8U 3
  • IP15 3

External Ids for IFITM3 Gene

Previous GeneCards Identifiers for IFITM3 Gene

  • GC11U990191
  • GC08P9A0176
  • GC11P000877
  • GC11M000309
  • GC11M000137

Summaries for IFITM3 Gene

Entrez Gene Summary for IFITM3 Gene

  • The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

GeneCards Summary for IFITM3 Gene

IFITM3 (Interferon Induced Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with IFITM3 include Influenza, Severe and West Nile Virus. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is IFITM2.

UniProtKB/Swiss-Prot for IFITM3 Gene

  • IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Gene Wiki entry for IFITM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM3 Gene

Genomics for IFITM3 Gene

Regulatory Elements for IFITM3 Gene


Enhancers around IFITM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFITM3 Gene

Chromosome:
11
Start:
319,669 bp from pter
End:
327,537 bp from pter
Size:
7,869 bases
Orientation:
Minus strand

Genomic View for IFITM3 Gene

Genes around IFITM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM3 Gene

Proteins for IFITM3 Gene

  • Protein details for IFITM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01628-IFM3_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 3
    Protein Accession:
    Q01628
    Secondary Accessions:
    • Q53Y76
    • Q96HK8
    • Q96J15

    Protein attributes for IFITM3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14632 Da
    Quaternary structure:
    • Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

neXtProt entry for IFITM3 Gene

Post-translational modifications for IFITM3 Gene

  • Not glycosylated.
  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Polyubiquitinated with both Lys-48 and Lys-63 linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
  • Ubiquitination at Lys 24, Lys 83, Lys 88, and Lys 104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFITM3 Gene

Antibody Products

  • R&D Systems Antibodies for IFITM3 (IFITM3/Fragilis)
  • Cell Signaling Technology (CST) Antibodies for IFITM3 (IFITM3)

No data available for DME Specific Peptides for IFITM3 Gene

Domains & Families for IFITM3 Gene

Protein Domains for IFITM3 Gene

Suggested Antigen Peptide Sequences for IFITM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01628

UniProtKB/Swiss-Prot:

IFM3_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM3: view

No data available for Gene Families for IFITM3 Gene

Function for IFITM3 Gene

Molecular function for IFITM3 Gene

UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18486613
genes like me logo Genes that share ontologies with IFITM3: view
genes like me logo Genes that share phenotypes with IFITM3: view

Animal Models for IFITM3 Gene

MGI Knock Outs for IFITM3:

Animal Model Products

miRNA for IFITM3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFITM3 Gene

Localization for IFITM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM3 Gene

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endosome 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IFITM3: view

Pathways & Interactions for IFITM3 Gene

genes like me logo Genes that share pathways with IFITM3: view

Pathways by source for IFITM3 Gene

Gene Ontology (GO) - Biological Process for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1906403
GO:0009607 response to biotic stimulus IEA --
GO:0009615 response to virus IDA 20943977
GO:0032897 negative regulation of viral transcription IDA 20943977
GO:0034341 response to interferon-gamma IDA 21253575
genes like me logo Genes that share ontologies with IFITM3: view

No data available for SIGNOR curated interactions for IFITM3 Gene

Transcripts for IFITM3 Gene

Unigene Clusters for IFITM3 Gene

Interferon induced transmembrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM3 Gene

No ASD Table

Relevant External Links for IFITM3 Gene

GeneLoc Exon Structure for
IFITM3
ECgene alternative splicing isoforms for
IFITM3

Expression for IFITM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFITM3 Gene

Protein differential expression in normal tissues from HIPED for IFITM3 Gene

This gene is overexpressed in Esophagus (14.3), Placenta (12.9), Stomach (7.8), and Fetal testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFITM3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IFITM3 Gene:

IFITM3

SOURCE GeneReport for Unigene cluster for IFITM3 Gene:

Hs.374650
genes like me logo Genes that share expression patterns with IFITM3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFITM3 Gene

Orthologs for IFITM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM3 34 35
  • 98.75 (n)
mouse
(Mus musculus)
Mammalia Ifitm3 34 16 35
  • 73.96 (n)
Ifitm1 35
  • 66 (a)
ManyToMany
Ifitm2 35
  • 59 (a)
ManyToMany
Gm7676 35
  • 57 (a)
ManyToMany
Gm2840 35
  • 54 (a)
ManyToMany
Ifitm7 35
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifitm3 34
  • 73.7 (n)
cow
(Bos Taurus)
Mammalia IFITM3 35
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 35
  • 32 (a)
ManyToMany
Species where no ortholog for IFITM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM3 Gene

ENSEMBL:
Gene Tree for IFITM3 (if available)
TreeFam:
Gene Tree for IFITM3 (if available)

Paralogs for IFITM3 Gene

Variants for IFITM3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM3 Gene

IFM3_HUMAN-Q01628
Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIM:614680].

Sequence variations from dbSNP and Humsavar for IFITM3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12252 other 320,772(-) AACAG(C/T)GGCCA nc-transcript-variant, reference, synonymous-codon
rs1060603 -- 319,916(-) AACAT(C/T)TGGGC nc-transcript-variant, reference, synonymous-codon
rs1060675 -- 319,903(-) TGATT(C/T)TGGGC nc-transcript-variant, reference, synonymous-codon
rs10794307 -- 322,722(+) AAACT(C/T)ATTCC upstream-variant-2KB
rs10902122 -- 321,239(+) CGCCG(C/T)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFITM3 Gene

Variant ID Type Subtype PubMed ID
nsv7212 OTHER inversion 18451855
nsv552768 CNV loss 21841781
nsv552765 CNV gain 21841781
nsv527327 CNV loss 19592680
nsv435976 OTHER inversion 17901297
esv3891905 CNV gain 25118596
dgv1505n54 CNV gain 21841781
dgv1012n100 CNV gain 25217958

Variation tolerance for IFITM3 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFITM3 Gene

Human Gene Mutation Database (HGMD)
IFITM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM3

Disorders for IFITM3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IFITM3 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
influenza, severe
  • influenza, severe, susceptibility to
west nile virus
  • west nile virus, susceptibility to
influenza
  • flu
rift valley fever
stomatitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFITM3

Genetic Association Database (GAD)
IFITM3
Human Genome Epidemiology (HuGE) Navigator
IFITM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFITM3
genes like me logo Genes that share disorders with IFITM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFITM3 Gene

Publications for IFITM3 Gene

  1. Molecular analysis of a human interferon-inducible gene family. (PMID: 1906403) Lewin A.R. … Kerr I.M. (Eur. J. Biochem. 1991) 2 3 4 22 64
  2. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. (PMID: 19946179) Seo G.S. … Choi S.C. (Exp. Mol. Med. 2010) 3 22 46 64
  3. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. (PMID: 23601107) Amini-Bavil-Olyaee S. … Jung J.U. (Cell Host Microbe 2013) 3 4 64
  4. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 64
  5. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. (PMID: 22479637) Chan Y.K. … Farzan M. (PLoS ONE 2012) 3 4 64

Products for IFITM3 Gene

Sources for IFITM3 Gene

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