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IFITM3 Gene

protein-coding   GIFtS: 63
GCID: GC11M000319

Interferon Induced Transmembrane Protein 3

(Previous name: interferon induced transmembrane protein 3 (1-8U))
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Induced Transmembrane Protein 31 2     Interferon Induced Transmembrane Protein 3 (1-8U)1
Dispanin Subfamily A Member 2b2 3     1-8U2
Interferon-Inducible Protein 1-8U2 3     IP152
DSPA2b2 3     Interferon-Induced Transmembrane Protein 32

External Ids:    HGNC: 54141   Entrez Gene: 104102   Ensembl: ENSG000001420897   OMIM: 6055795   UniProtKB: Q016283   

Export aliases for IFITM3 gene to outside databases

Previous GC identifers: GC11U990191 GC08P9A0176 GC11P000877 GC11M000309 GC11M000137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFITM3 Gene:
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza
A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have
been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the
full-length nature of this variant has not been determined. (provided by RefSeq, May 2012)

GeneCards Summary for IFITM3 Gene:
IFITM3 (interferon induced transmembrane protein 3) is a protein-coding gene. Diseases associated with IFITM3 include pericardial tuberculosis, and influenza, severe. An important paralog of this gene is IFITM1.

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
Function: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry
of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May
inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol
depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV),
Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency
virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin
protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry
and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of
vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for
proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic
endosomes thus establishing an antiviral state

Gene Wiki entry for IFITM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFITM3 gene promoter:
         GR   STAT1   GATA-3   Pax-5   Cart-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM3 promoter sequence
   Search Chromatin IP Primers for IFITM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFITM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000319:  view genomic region     (about GC identifiers)

Start:
319,669 bp from pter      End:
327,537 bp from pter
Size:
7,869 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 3  
Size: 133 amino acids; 14632 Da
Subunit: Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN
expression. Interacts with VAPA
Secondary accessions: Q53Y76 Q96HK8 Q96J15

Explore the universe of human proteins at neXtProt for IFITM3: NX_Q01628

Explore proteomics data for IFITM3 at MOPED

Post-translational modifications: 

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    against influenza virus1
  • Not glycosylated1
  • Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity.
    Lys-24 is the most prevalent ubiquitination site1
  • Ubiquitination2 at Lys24, Lys83, Lys88, Lys104
  • Modification sites at PhosphoSitePlus

  • See IFITM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066362.2  
    ENSEMBL proteins: 
     ENSP00000382707   ENSP00000473645   ENSP00000432108   ENSP00000473544  
    Reactome Protein details: Q01628

    IFITM3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IFITM3
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    Novus Biologicals IFITM3 Protein
    Novus Biologicals IFITM3 Lysates
    Sino Biological Recombinant Protein for IFITM3
    Sino Biological Cell Lysate for IFITM3
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    Cloud-Clone Corp. Proteins for IFITM3

    IFITM3 Antibody Products:

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    ThermoFisher Antibodies for IFITM3
    LSBio Antibodies in human, mouse, rat for IFITM3

    IFITM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IFITM3
    Cloud-Clone Corp. CLIAs for IFITM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007593 CD225/Dispanin_fam

    Graphical View of Domain Structure for InterPro Entry Q01628

    ProtoNet protein and cluster: Q01628

    1 Blocks protein domain: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
    Similarity: Belongs to the CD225/Dispanin family


    IFITM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFM3_HUMAN, Q01628
    Function: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry
    of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May
    inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol
    depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV),
    Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency
    virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin
    protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry
    and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of
    vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for
    proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic
    endosomes thus establishing an antiviral state
    Induction: By IFN-alpha and IFNG/IFN-gamma

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18486613
         
    IFITM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFITM3:
     Increased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFITM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFITM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFITM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFITM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFITM3:
    hsa-mir-26b-5p (MIRT029884), hsa-mir-146a-5p (MIRT021237)

    Block miRNA regulation of human, mouse, rat IFITM3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM3
    SwitchGear 3'UTR luciferase reporter plasmidIFITM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFITM3
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IFITM3

    Clone
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    OriGene clones in human, mouse for IFITM3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM3 (NM_021034)
    Sino Biological Human cDNA Clone for IFITM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFITM3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFM3_HUMAN, Q01628: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass
    type II membrane protein. Lysosome membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031902late endosome membrane IEA--

    IFITM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFITM3 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IFITM3
        Interferon alpha/beta signaling



    IFITM3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including IFITM3: 
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFITM3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IFITM3 (Q016281, 2, 3 ENSP000003827074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAMPTP434901, 2, 3, ENSP000002225534EBI-7932862,EBI-2829310 MINT-6538727 MINT-6538811 MINT-6538868 I2D: score=1 STRING: ENSP00000222553
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1906403
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032897negative regulation of viral transcription IDA--

    IFITM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFITM3 (IFM3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IFITM3 gene: 
    NM_021034.2  

    Unigene Cluster for IFITM3:

    Interferon induced transmembrane protein 3
    Hs.374650  [show with all ESTs]
    Unigene Representative Sequence: BF965170
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399808(uc001lpa.2) ENST00000531688 ENST00000526811 ENST00000602735

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFITM3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM3
    SwitchGear 3'UTR luciferase reporter plasmidIFITM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFITM3
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM3
    Clone
    Products:
         
    OriGene clones in human, mouse for IFITM3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM3 (NM_021034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFITM3
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFITM3
      QuantiTect SYBR Green Assays in human, mouse, rat IFITM3
      QuantiFast Probe-based Assays in human, mouse, rat IFITM3

    Additional mRNA sequence: 

    AK292173.1 BC006794.1 BC008417.1 BC022439.1 BC070243.1 BT006892.1 NR_049759.1 X57352.1 

    22 DOTS entries:

    DT.91775643  DT.91775637  DT.95297793  DT.95164281  DT.95164279  DT.120685634  DT.91819285  DT.100866643 
    DT.121113555  DT.98131772  DT.100640234  DT.100687220  DT.100687374  DT.120685623  DT.120685627  DT.120685646 
    DT.121232294  DT.86996321  DT.87017823  DT.95164232  DT.121113556  DT.86855828 

    Selected AceView cDNA sequences (see all 929):

    BU179556 BE787087 AI754997 CB108787 BI835168 CD558872 AI144547 BU145809 
    BU616310 AA410598 CN480937 AW368890 BQ441207 BF340485 BQ688462 BQ574611 
    CB110922 AA303475 BM662610 CF995470 BC070243 BU943897 CB124174 BQ937265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFITM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTATCC
    IFITM3 Expression
    About this image


    IFITM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian tissue-dissociated cells (human)
             Ddx4-positive cells
     
     Gonad
             Human oogonial stem cells
     
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    IFITM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFITM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374650
        Pathway & Disease-focused RT2 Profiler PCR Array including IFITM3: 
              Type I Interferon Response in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IFITM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFITM3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifitm31 interferon induced transmembrane protein 3 73.96(n)
    70.31(a)
      66141  NM_025378.2  NP_079654.1 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    1 → many
    5(1592827-1594156) ENSGALG00000026970
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-226m8.76
    si:dkey-226m8.7
    32(a)
    many ↔ many
    5(34876187-34876977) ENSDARG00000093303


    ENSEMBL Gene Tree for IFITM3 (if available)
    TreeFam Gene Tree for IFITM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFITM3 gene
    IFITM12  IFITM52  IFITM22  IFITM102  ENSG000002506442  
    4 SIMAP similar genes for IFITM3 using alignment to 6 protein entries:     IFM3_HUMAN (see all proteins):
    IFITM2    IFITM1    IFITM10    IFITM5

    IFITM3 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for IFITM3 (see all 19)
    PGOHUM00000262863 PGOHUM00000258625 PGOHUM00000258670 PGOHUM00000261148 PGOHUM00000243936


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IFM3_HUMAN, Q01628: Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection
    [MIM:614680]


    Selected SNPs for IFITM3 (see all 224)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492742061,2
    --260061(+) CCCCTC/TTGAGG 2 -- us2k10--------
    rs1820577391,2
    --260100(+) ATTTAG/TTTTTT 2 -- us2k10--------
    rs1860225301,2
    --260112(+) GAGTCA/GGAGTC 2 -- us2k10--------
    rs96665041,2
    C--260182(+) ctcccG/Aggttc 2 -- us2k17Minor allele frequency- A:0.00NA WA CSA 12
    rs1479872621,2
    --260288(+) TTTCAC/TGTGTT 2 -- us2k10--------
    rs79392611,2
    C--260309(-) gagatC/Ggagac 2 -- us2k10--------
    rs1892864051,2
    C--260323(+) ACCTCA/GTGATC 2 -- us2k10--------
    rs96662951,2
    C,F,A--260342(+) TCGGCT/CTCCCA 2 -- us2k18Minor allele frequency- C:0.21NA WA CSA 14
    rs1809968201,2
    --260377(+) CCACCA/GCGCCC 2 -- us2k10--------
    rs1164930621,2
    F--260422(+) GTGTCC/TAGTTC 2 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for IFITM3 (319669 - 327537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IFITM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527327CNV Loss19592680
    dgv917n71CNV Loss21882294
    dgv914n71CNV Loss21882294
    dgv915n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    nsv896447CNV Loss21882294
    nsv896463CNV Gain21882294
    dgv911n71CNV Gain21882294
    nsv435976OTHER Inversion17901297
    nsv7212OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): IFITM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFITM3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605579   
    OMIM disorders: 614680  
    14 diseases for IFITM3:    
    About MalaCards
    pericardial tuberculosis    influenza, severe    west nile virus    influenza
    rift valley fever    stomatitis    ulcerative colitis    tuberculosis
    hepatitis c    prostate cancer    hiv-1    prostatitis
    hepatitis    melanoma


    IFITM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IFITM3
    Human Genome Epidemiology (HuGE) Navigator: IFITM3 (1 document)

    Export disorders for IFITM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFITM3 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with IFITM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of a human interferon-inducible gene family. (PubMed id 1906403)1, 2, 3, 9 Lewin A.R.... Kerr I.M. (Eur. J. Biochem. 1991)
    2. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. (PubMed id 19946179)1, 4, 9 Seo G.S....Choi S.C. (amp 2010)
    3. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. (PubMed id 23601107)1, 2 Amini-Bavil-Olyaee S.... Jung J.U. (Cell Host Microbe 2013)
    4. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)1, 2 Sallman Almen M.... Schioth H.B. (PLoS ONE 2012)
    5. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. (PubMed id 22511783)1, 2 Yount J.S.... Hang H.C. (J. Biol. Chem. 2012)
    6. IFITM3 restricts the morbidity and mortality associated with influenza. (PubMed id 22446628)1, 2 Everitt A.R....Kellam P. (Nature 2012)
    7. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J.... Liang C. (J. Virol. 2011)
    8. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. (PubMed id 19901966)1, 2 El-Tanani M.K.... Johnston P.G. (Oncogene 2010)
    9. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. (PubMed id 20534863)1, 2 Jiang D.... Guo J.T. (J. Virol. 2010)
    10. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. (PubMed id 16326387)1, 3 Tanaka S.S....Tam P.P. (Dev. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10410 HGNC: 5414 AceView: IFITM3 Ensembl:ENSG00000142089 euGenes: HUgn10410
    ECgene: IFITM3 H-InvDB: IFITM3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFITM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IFITM3 gene:
    Search GeneIP for patents involving IFITM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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