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Aliases for IFITM3 Gene

Aliases for IFITM3 Gene

  • Interferon Induced Transmembrane Protein 3 2 3
  • Interferon-Inducible Protein 1-8U 3 4
  • Dispanin Subfamily A Member 2b 3 4
  • DSPA2b 3 4
  • Interferon Induced Transmembrane Protein 3 (1-8U) 2
  • Interferon-Induced Transmembrane Protein 3 3
  • 1-8U 3
  • IP15 3

External Ids for IFITM3 Gene

Summaries for IFITM3 Gene

Entrez Gene Summary for IFITM3 Gene

  • The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

GeneCards Summary for IFITM3 Gene

IFITM3 (Interferon Induced Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with IFITM3 include influenza and influenza, severe. Among its related pathways are Interferon Signaling and Interferon Signaling. An important paralog of this gene is IFITM1.

UniProtKB/Swiss-Prot for IFITM3 Gene

  • IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Gene Wiki entry for IFITM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM3 Gene

Genomics for IFITM3 Gene

Genomic Location for IFITM3 Gene

Start:
319,669 bp from pter
End:
327,537 bp from pter
Size:
7,869 bases
Orientation:
Minus strand

Genomic View for IFITM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFITM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM3 Gene

Regulatory Elements for IFITM3 Gene

Proteins for IFITM3 Gene

  • Protein details for IFITM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01628-IFM3_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 3
    Protein Accession:
    Q01628
    Secondary Accessions:
    • Q53Y76
    • Q96HK8
    • Q96J15

    Protein attributes for IFITM3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14632 Da
    Quaternary structure:
    • Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

neXtProt entry for IFITM3 Gene

Proteomics data for IFITM3 Gene at MOPED

Post-translational modifications for IFITM3 Gene

  • Not glycosylated
  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Polyubiquitinated with both Lys-48 and Lys-63 linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24, Lys83, Lys88, and Lys104

Other Protein References for IFITM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFITM3 Gene

Domains for IFITM3 Gene

Protein Domains for IFITM3 Gene

UniProtKB/Swiss-Prot:

IFM3_HUMAN
Family:
  • Belongs to the CD225/Dispanin family.:
    • Q01628
genes like me logo Genes that share domains with IFITM3: view

No data available for Gene Families for IFITM3 Gene

Function for IFITM3 Gene

Molecular function for IFITM3 Gene

UniProtKB/Swiss-Prot Function: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
UniProtKB/Swiss-Prot Induction: By IFN-alpha and IFNG/IFN-gamma

Gene Ontology (GO) - Molecular Function for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18486613
genes like me logo Genes that share ontologies with IFITM3: view

Phenotypes for IFITM3 Gene

GenomeRNAi human phenotypes for IFITM3:
genes like me logo Genes that share phenotypes with IFITM3: view

miRNA for IFITM3 Gene

miRTarBase miRNAs that target IFITM3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFITM3 Gene

Localization for IFITM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM3 Gene

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFITM3 Gene COMPARTMENTS Subcellular localization image for IFITM3 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM3: view

Pathways for IFITM3 Gene

genes like me logo Genes that share pathways with IFITM3: view

Pathways by source for IFITM3 Gene

Gene Ontology (GO) - Biological Process for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1906403
GO:0009607 response to biotic stimulus --
GO:0009615 response to virus IDA 20943977
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IDA 20943977
genes like me logo Genes that share ontologies with IFITM3: view

Transcripts for IFITM3 Gene

Unigene Clusters for IFITM3 Gene

Interferon induced transmembrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM3 Gene

No ASD Table

Relevant External Links for IFITM3 Gene

GeneLoc Exon Structure for
IFITM3
ECgene alternative splicing isoforms for
IFITM3

Expression for IFITM3 Gene

mRNA expression in normal human tissues for IFITM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFITM3 Gene

SOURCE GeneReport for Unigene cluster for IFITM3 Gene Hs.374650

genes like me logo Genes that share expressions with IFITM3: view

Orthologs for IFITM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM3 36
  • 98.75 (n)
  • 99.25 (a)
IFITM3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFITM3 37
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 53 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm2840 37
  • 54 (a)
ManyToMany
Gm7676 37
  • 57 (a)
ManyToMany
Ifitm1 37
  • 66 (a)
ManyToMany
Ifitm2 37
  • 59 (a)
ManyToMany
Ifitm3 36
  • 73.96 (n)
  • 70.31 (a)
Ifitm3 37
  • 65 (a)
ManyToMany
Ifitm7 37
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifitm3 36
  • 73.7 (n)
  • 71.09 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 37
  • 32 (a)
ManyToMany
Species with no ortholog for IFITM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM3 Gene

ENSEMBL:
Gene Tree for IFITM3 (if available)
TreeFam:
Gene Tree for IFITM3 (if available)

Paralogs for IFITM3 Gene

Paralogs for IFITM3 Gene

Selected SIMAP similar genes for IFITM3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IFITM3: view

Variants for IFITM3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM3 Gene

Q01628-IFM3_HUMAN
Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIM:614680]

Sequence variations from dbSNP and Humsavar for IFITM3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8710 -- 319,676(-) TCTGG(A/T)GCTGC utr-variant-3-prime, nc-transcript-variant
rs12252 other 320,772(-) AACAG(C/T)GGCCA synonymous-codon, reference, nc-transcript-variant
rs1060603 -- 319,916(-) AACAT(C/T)TGGGC reference, synonymous-codon, nc-transcript-variant
rs1060675 -- 319,903(-) TGATT(C/T)TGGGC reference, synonymous-codon, nc-transcript-variant
rs1136853 - 320,805(-) AATCA(A/C)ACTGT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IFITM3 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
nsv896447 CNV Loss 21882294
dgv914n71 CNV Loss 21882294
dgv915n71 CNV Loss 21882294
nsv7212 OTHER Inversion 18451855
dgv916n71 CNV Loss 21882294
dgv917n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
nsv435976 OTHER Inversion 17901297

Relevant External Links for IFITM3 Gene

HapMap Linkage Disequilibrium report
IFITM3
Human Gene Mutation Database (HGMD)
IFITM3

Disorders for IFITM3 Gene

(1) OMIM Diseases for IFITM3 Gene (605579)

Relevant External Links for IFITM3

Genetic Association Database (GAD)
IFITM3
Human Genome Epidemiology (HuGE) Navigator
IFITM3
genes like me logo Genes that share disorders with IFITM3: view

No data available for UniProtKB/Swiss-Prot for IFITM3 Gene

Publications for IFITM3 Gene

  1. Molecular analysis of a human interferon-inducible gene family. (PMID: 1906403) Lewin A.R. … Kerr I.M. (Eur. J. Biochem. 1991) 2 3 4 23
  2. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. (PMID: 19946179) Seo G.S. … Choi S.C. (Exp. Mol. Med. 2010) 3 23 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. (PMID: 16326387) Tanaka S.S. … Tam P.P. (Dev. Cell 2005) 2 3
  5. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. (PMID: 19901966) El-Tanani M.K. … Johnston P.G. (Oncogene 2010) 3 4

Products for IFITM3 Gene

Sources for IFITM3 Gene

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