Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFITM3 Gene

protein-coding   GIFtS: 62
GCID: GC11M000319

Interferon Induced Transmembrane Protein 3

(Previous name: interferon induced transmembrane protein 3 (1-8U))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Induced Transmembrane Protein 31 2     Interferon Induced Transmembrane Protein 3 (1-8U)1
Dispanin Subfamily A Member 2b2 3     1-8U2
Interferon-Inducible Protein 1-8U2 3     IP152
DSPA2b2 3     Interferon-Induced Transmembrane Protein 32

External Ids:    HGNC: 54141   Entrez Gene: 104102   Ensembl: ENSG000001420897   OMIM: 6055795   UniProtKB: Q016283   

Export aliases for IFITM3 gene to outside databases

Previous GC identifers: GC11U990191 GC08P9A0176 GC11P000877 GC11M000309 GC11M000137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFITM3 Gene:
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza
A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have
been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the
full-length nature of this variant has not been determined. (provided by RefSeq, May 2012)

GeneCards Summary for IFITM3 Gene: 
IFITM3 (interferon induced transmembrane protein 3) is a protein-coding gene. Diseases associated with IFITM3 include west nile virus, and pericardial tuberculosis, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. An important paralog of this gene is IFITM1.

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and
Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV
and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral
entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes
physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also
required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral
state

Gene Wiki entry for IFITM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFITM3 gene promoter:
         GR   STAT1   GATA-3   Pax-5   Cart-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFITM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000319:  view genomic region     (about GC identifiers)

Start:
319,669 bp from pter      End:
327,537 bp from pter
Size:
7,869 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 3  
Size: 133 amino acids; 14632 Da
Subunit: Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81 (By
similarity)
Subcellular location: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass
type II membrane protein. Lysosome membrane; Single-pass type II membrane protein
Secondary accessions: Q53Y76 Q96HK8 Q96J15

Explore the universe of human proteins at neXtProt for IFITM3: NX_Q01628

Explore proteomics data for IFITM3 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    against influenza virus
  • UniProtKB: Not glycosylated
  • UniProtKB: Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity.
    Lys-24 is the most prevalent ubiquitination site
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01628

  • IFITM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFITM3 Protein Expression
    REFSEQ proteins: NP_066362.2  
    ENSEMBL proteins: 
     ENSP00000382707   ENSP00000473645   ENSP00000432108   ENSP00000473544  
    Reactome Protein details: Q01628
    Human Recombinant Protein Products for IFITM3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IFITM3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IFITM3
    GenScript Custom Purified and Recombinant Proteins Services for IFITM3
    Novus Biologicals IFITM3 Protein
    Novus Biologicals IFITM3 Lysates
    Sino Biological Recombinant Protein for IFITM3
    Sino Biological Cell Lysate for IFITM3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFITM3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031902late endosome membrane IEA--

    IFITM3 for ontologies           About GeneDecksing



    IFITM3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IFITM3 (IFITM3/Fragilis)
    OriGene Antibodies for IFITM3
    OriGene Custom Antibody Services for IFITM3
    GenScript Custom Superior Antibodies Services for IFITM3
    Novus Biologicals IFITM3 Antibodies
    Abcam antibodies for IFITM3
    Cloud-Clone Corp. Antibodies for IFITM3 
    ThermoFisher Antibodies for IFITM3
    LSBio Antibodies in human, mouse, rat for IFITM3 

    Assay Products for IFITM3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFITM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFITM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFITM3 
    Cloud-Clone Corp. CLIAs for IFITM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007593 Interferon-induced_TM_protein

    Graphical View of Domain Structure for InterPro Entry Q01628

    ProtoNet protein and cluster: Q01628

    1 Blocks protein domain: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
    Similarity: Belongs to the CD225/Dispanin family


    IFITM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFM3_HUMAN, Q01628
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
    against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and
    Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
    vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV
    and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral
    entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes
    physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also
    required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral
    state
    Induction: By IFN-alpha and IFNG/IFN-gamma

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18486613
         
    IFITM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFITM3:
     Increased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFITM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFITM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFITM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFITM3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFITM3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFITM3
    SwitchGear 3'UTR luciferase reporter plasmidIFITM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFITM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFITM3
    Sirion Biotech Customized adenovirus for overexpression of IFITM3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IFITM3 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM3 (NM_021034)
    Sino Biological Human cDNA Clone for IFITM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM3
    Sirion Biotech Customized lentivirus for stable overexpression of IFITM3 
                         Customized lentivirus expression plasmids for stable overexpression of IFITM3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFITM3
    Search LifeMap BioReagents cell lines for IFITM3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFITM3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for IFITM3
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    IFITM3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFITM3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IFITM3 (Q016282, 3 ENSP000003827074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAMPTP434902, 3, ENSP000002225534MINT-6538727 MINT-6538811 MINT-6538868 I2D: score=1 STRING: ENSP00000222553
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1906403
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032897negative regulation of viral transcription IDA--

    IFITM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFITM3 (IFM3)

    Search CenterWatch for drugs/clinical trials and news about IFITM3 / IFM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFITM3 gene: 
    NM_021034.2  

    Unigene Cluster for IFITM3:

    Interferon induced transmembrane protein 3
    Hs.374650  [show with all ESTs]
    Unigene Representative Sequence: BF965170
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399808(uc001lpa.2) ENST00000531688 ENST00000526811 ENST00000602735

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFITM3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFITM3
    SwitchGear 3'UTR luciferase reporter plasmidIFITM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFITM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM3
    Clone
    Products:
         
    OriGene clones in human, mouse for IFITM3 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM3 (NM_021034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM3
    Sirion Biotech Customized lentivirus for stable overexpression of IFITM3 
                         Customized lentivirus expression plasmids for stable overexpression of IFITM3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFITM3
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFITM3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM3

    Additional mRNA sequence: 

    AK292173.1 BC006794.1 BC008417.1 BC022439.1 BC070243.1 BT006892.1 NR_049759.1 X57352.1 

    22 DOTS entries:

    DT.91775643  DT.91775637  DT.95297793  DT.95164281  DT.95164279  DT.120685634  DT.91819285  DT.100866643 
    DT.121113555  DT.98131772  DT.100640234  DT.100687220  DT.100687374  DT.120685623  DT.120685627  DT.120685646 
    DT.121232294  DT.86996321  DT.87017823  DT.95164232  DT.121113556  DT.86855828 

    24/929 AceView cDNA sequences (see all 929):

    BM768624 BQ679581 BQ379745 BM663215 BU849173 BI835168 AA410248 BU615735 
    AA402017 BM552366 BM768718 CB111049 AA528194 BQ650024 BI254033 AI890765 
    BU728111 BM888177 BM826807 CD674337 BQ681235 CN484945 AW368896 AA375582 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFITM3 expression in normal human tissues (normalized intensities)      IFITM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTATCC
    IFITM3 Expression
    About this image


    IFITM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Ovary (Reproductive System)
             Ovarian tissue-dissociated cells (human)
     
     Endothelium (Cardiovascular System)
             Peripheral blood endothelial colony-forming cells

    See IFITM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFITM3

    SOURCE GeneReport for Unigene cluster: Hs.374650
        SABiosciences Expression via Pathway-Focused PCR Array including IFITM3: 
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFITM3
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFITM3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFITM3 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    31(a)
    1 → many
    5(1592827-1594156)
            Species with no ortholog for IFITM3

    ENSEMBL Gene Tree for IFITM3 (if available)
    TreeFam Gene Tree for IFITM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFITM3 gene
    IFITM12  IFITM52  IFITM22  IFITM102  ENSG000002506442  
    4 SIMAP similar genes for IFITM3 using alignment to 6 protein entries:     IFM3_HUMAN (see all proteins):
    IFITM2    IFITM1    IFITM10    IFITM5

    IFITM3 for paralogs           About GeneDecksing


    5/19 Pseudogenes.org Pseudogenes for IFITM3 (see all 19)
    PGOHUM00000262863 PGOHUM00000258625 PGOHUM00000258670 PGOHUM00000261148 PGOHUM00000243936


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
    Polymorphism: Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection
    [MIM:614680]


    10/224 SNPs in IFITM3 are shown (see all 224)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492742061,2
    --260061(+) CCCCTC/TTGAGG 2 -- us2k10--------
    rs1820577391,2
    --260100(+) ATTTAG/TTTTTT 2 -- us2k10--------
    rs1860225301,2
    --260112(+) GAGTCA/GGAGTC 2 -- us2k10--------
    rs96665041,2
    C--260182(+) ctcccG/Aggttc 2 -- us2k17Minor allele frequency- A:0.00NA WA CSA 12
    rs1479872621,2
    --260288(+) TTTCAC/TGTGTT 2 -- us2k10--------
    rs79392611,2
    C--260309(-) gagatC/Ggagac 2 -- us2k10--------
    rs1892864051,2
    C--260323(+) ACCTCA/GTGATC 2 -- us2k10--------
    rs96662951,2
    C,F,A--260342(+) TCGGCT/CTCCCA 2 -- us2k18Minor allele frequency- C:0.21NA WA CSA 14
    rs1809968201,2
    --260377(+) CCACCA/GCGCCC 2 -- us2k10--------
    rs1164930621,2
    F--260422(+) GTGTCC/TAGTTC 2 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for IFITM3 (319669 - 327537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IFITM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527327CNV Loss19592680
    dgv917n71CNV Loss21882294
    dgv914n71CNV Loss21882294
    dgv915n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    nsv896447CNV Loss21882294
    nsv896463CNV Gain21882294
    dgv911n71CNV Gain21882294
    nsv435976OTHER Inversion17901297
    nsv7212OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): IFITM3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFITM3
    DNA2.0 Custom Variant and Variant Library Synthesis for IFITM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605579    OMIM disorders: --

    12 diseases for IFITM3:    About MalaCards
    west nile virus    pericardial tuberculosis    influenza    prostate cancer, progression of
    stomatitis    ulcerative colitis    hepatitis c    prostate cancer
    colon cancer    prostatitis    hepatitis    tuberculosis


    IFITM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IFITM3
    Human Genome Epidemiology (HuGE) Navigator: IFITM3 (1 document)

    Export disorders for IFITM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFITM3 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with IFITM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of a human interferon-inducible gene family. (PubMed id 1906403)1, 2, 3, 9 Lewin A.R.... Kerr I.M. (1991)
    2. Identification of the polymorphisms in IFITM3 gene an d their association in a Korean population with ulcerative colitis. (PubMed id 19946179)1, 4, 9 Seo G.S....Choi S.C. (2010)
    3. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. (PubMed id 22511783)1, 2 Yount J.S.... Hang H.C. (2012)
    4. IFITM3 restricts the morbidity and mortality associated with influenza. (PubMed id 22446628)1, 2 Everitt A.R....Kellam P. (2012)
    5. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J....Liang C. (2011)
    6. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. (PubMed id 19901966)1, 2 El-Tanani M.K....Johnston P.G. (2010)
    7. Identification of five interferon-induced cellular pr oteins that inhibit west nile virus and dengue virus infections. (PubMed id 20534863)1, 2 Jiang D....Guo J.T. (2010)
    8. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. (PubMed id 16326387)1, 3 Tanaka S.S....Tam P.P. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Characteristics of IFITM, the newly identified IFN-ind ucible anti-HIV-1 family proteins. (PubMed id 23376165)1 Chutiwitoonchai N....Suzu S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10410 HGNC: 5414 AceView: IFITM3 Ensembl:ENSG00000142089 euGenes: HUgn10410
    ECgene: IFITM3 H-InvDB: IFITM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFITM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFITM3 gene:
    Search GeneIP for patents involving IFITM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IFITM3 (IFITM3/Fragilis)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IFITM3   OriGene RNAi products in human, mouse, rat for IFITM3  
     OriGene qPCR primer pairs and template standards for IFITM3   OriGene Protein Over-expression Lysate for IFITM3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IFITM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for IFITM3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFITM3   OriGene Custom Protein Services for IFITM3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFITM3
     QIAGEN SeqTarget long-range PCR primers for resequencing IFITM3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM3
     GenScript Custom Purified and Recombinant Proteins Services for IFITM3 GenScript cDNA clones with any tag delivered in your preferred vector for IFITM3
     GenScript Custom Assay Services for IFITM3 GenScript Custom Superior Antibodies Services for IFITM3
     GenScript Custom overexpressing Cell Line Services for IFITM3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IFITM3 promoter
     Search Chromatin IP Primers for IFITM3
     RT2 qPCR Primer Assay in human, mouse, rat IFITM3
     GNC Network for IFITM3
     SABiosciences PCR Arrays including human, mouse, rat IFITM3
     Search Tocris compounds for IFITM3 (IFM3)
     Proteins and Antibodies for IFITM3
     Cell Lysates for IFITM3
     cDNA Clones for IFITM3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IFITM3 antibodies
     IFITM3 proteins
     IFITM3 lysates
     Antibodies for IFITM3
     See all of Abcam's Antibodies, Kits and Proteins for IFITM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for IFITM3
     Antibodies for IFITM3
     ELISAs for IFITM3
     CLIAs for IFITM3
     Search LifeMap BioReagents cell lines for IFITM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM3
     SwitchGear 3'UTR luciferase reporter plasmids for IFITM3
     SwitchGear Promoter luciferase reporter plasmids for IFITM3
     ThermoFisher Antibodies for IFITM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IFITM3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFITM3
    Customized:
     lentivirus for stable overexpression of IFITM3
     lentivirus expression plasmids for stable overexpression of IFITM3
     adenovirus for overexpression of IFITM3
     LSBio Antibodies in human, mouse, rat for IFITM3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFITM3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4