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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFITM3 Gene

protein-coding GIFtS: 59
GCID: GC11M000319

interferon induced transmembrane protein 3

(Previous name: interferon induced transmembrane protein 3 (1-8U) )

Explore 10 diseases affiliated with
IFITM3 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon Induced Transmembrane Protein 3¹ ²		DSPA2b² ³
1-8U¹ ²		Interferon Induced Transmembrane Protein 3 (1-8U)¹
Dispanin Subfamily A Member 2b² ³		IP15²
Interferon-Inducible Protein 1-8U² ³		Interferon-Induced Transmembrane Protein 3²

External Ids:	HGNC: 5414¹	Entrez Gene: 10410²	Ensembl: ENSG00000142089⁷	OMIM: 605579⁵	UniProtKB: Q01628³

Export aliases for IFITM3 gene to outside databases

Previous GC identifers: GC11U990191 GC08P9A0176 GC11P000877 GC11M000309 GC11M000137

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFITM3:

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A

H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been

found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length

nature of this variant has not been determined. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628

Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting

endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against

multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus

(EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular

stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV

GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a

critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact

with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the

function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state

Gene Wiki entry for IFITM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFITM3 gene promoter:
GR STAT1 GATA-3 Pax-5 Cart-1 STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM3 promoter sequence

Search SABiosciences Chromatin IP Primers for IFITM3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

IFITM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000319: view genomic region (about GC identifiers)

Start:	319,669 bp from pter	End:	321,340 bp from pter
Size:	1,672 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628 (See protein sequence)

Recommended Name: Interferon-induced transmembrane protein 3

Size: 133 amino acids; 14632 Da

Subunit: Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81 (By similarity)

Subcellular location: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II

membrane protein. Lysosome membrane; Single-pass type II membrane protein

Secondary accessions: Q53Y76 Q96HK8 Q96J15

Explore the universe of human proteins at neXtProt for IFITM3: NX_Q01628

Post-translational modifications:

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity

against influenza virus¹

Not glycosylated¹

Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity.

Lys-24 is the most prevalent ubiquitination site¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01628

IFITM3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066362.2

ENSEMBL proteins:

ENSP00000382707 ENSP00000432108

Reactome Protein details: Q01628
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IFITM3 OriGene Custom Protein Services for IFITM3
	GenScript Custom Purified and Recombinant Proteins Services for IFITM3
	Novus Biologicals IFITM3 Protein Novus Biologicals IFITM3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IFITM3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0031902	late endosome membrane	IEA	--

IFITM3 for ontologies About GeneDecksing

IFITM3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IFITM3 (IFITM3/Fragilis)
	OriGene Antibodies: IFITM3 OriGene Custom Antibody Services for IFITM3
	GenScript Custom Superior Antibodies Services for IFITM3
	Novus Biologicals IFITM3 Antibodies
	Abcam antibodies for IFITM3
	Uscn Antibodies for IFITM3
	ThermoFisher Antibodies for IFITM3

Assay Products for IFITM3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IFITM3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IFITM3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFITM3 for domains About GeneDecksing

1 InterPro domain/family:

IPR007593 Interferon-induced_TM_protein

Graphical View of Domain Structure for InterPro Entry Q01628

ProtoNet protein and cluster: Q01628

1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein

UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628

Similarity: Belongs to the CD225/Dispanin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: