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IFITM3 Gene

protein-coding   GIFtS: 59

GC11M000309
interferon induced transmembrane protein 3 (1-8U)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
1-8U 1, 2
IP15 2
interferon-inducible 2
Descriptions
Interferon-inducible protein 1-8U 3
interferon induced transmembrane protein 3 (1-8U) 2
interferon-induced transmembrane protein 3 (1-8U) 2
External Ids
HGNC: 54141
Entrez Gene: 104102
UniProtKB: Q016283
Ensembl: ENSG000001420897
Search outside databases for aliases for IFITM3 gene

Previous GC identifers: GC11U990191 GC08P9A0176 GC11P000877

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for IFITM3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFITM3 gene  

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000309:     (about GC identifiers)

Start:
309,673 bp from pter
End:
310,914 bp from pter
Size:
1,242 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_035113.6  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 3  
Size: 133 amino acids; 14632 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q96HK8 Q96J15

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_066362.2  

    ENSEMBL proteins: 
    ENSP00000382707 ENSP00000372047 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Fragilis)
    Human Recombinant Proteins from Abnova (IFITM3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794 Golgi apparatus IDA18029348
    GO:0005886 plasma membrane IDA11256614
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for IFITM3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IFITM3
    R&D Systems Antibodies for IFITM3 (IFITM3/Fragilis)
    Antibodies from Abcam (Fragilis), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (IFITM3)
    Novus Biologicals Antibodies for IFITM3

    Assays for IFITM3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR007593 Interferon-induced_TM_protein


       GeneDecks  IFITM3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q01628

    ProtoNet protein and cluster: Q01628

    1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
    Similarity: Belongs to the CD225 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFITM3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021034

                  Applied Biosystems Silencer® siRNAs for IFITM3

                  Sigma-Aldrich siRNA for IFITM3  
                         Sigma-Aldrich shRNA for IFITM3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IFITM3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021034
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021034
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021034 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021034

    UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628
    Induction: By alpha and gamma interferons

    2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ifitm3):

    embryogenesisreproductive system

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  IFITM3 


    1 Interacting protein for IFITM3 (Q016282) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAMPTP434902MINT-6538727 MINT-6538811 MINT-6538868
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response TAS1906403
    GO:0009607 response to biotic stimulus IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IFITM3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFITM3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021034

                  Sigma-Aldrich siRNA for IFITM3  
                         Sigma-Aldrich shRNA for IFITM3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021034  

    REFSEQ mRNAs for IFITM3 gene: 

    NM_021034.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021034  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021034
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021034
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021034 

    Additional cDNA sequence: 

    AK292173.1 BC006794.1 BC008417.1 BC022439.1 BC070243.1 BT006892.1 CR611877.1 X57352.1 

    22 DOTS entries:

    DT.91775643  DT.91775637  DT.95297793  DT.95164281  DT.95164279  DT.120685634  DT.91819285  DT.100866643 
    DT.121113555  DT.98131772  DT.100640234  DT.100687220  DT.100687374  DT.120685623  DT.120685627  DT.120685646 
    DT.121232294  DT.86996321  DT.87017823  DT.95164232  DT.121113556  DT.86855828 

    24/929 AceView cDNA sequences (see all 929 ):

    AA303810 BU521278 CB126237 CB111016 BQ677873 BM768624 AI754997 BQ477496 
    CD108602 CF995470 CA431735 BQ574611 BE787087 BM927811 AA320471 AA410248 
    CN480937 CA428023 AI870213 BM810730 AA340840 CA428710 BI254033 AA303697 

    highest scoring ESTs for IFITM3:

    X57352 AA057643 AA074734 AA090345 AA094193 AA100966 AA102576 AA186840 AA304206 AA309081 

    Unigene Cluster for IFITM3:

    Interferon induced transmembrane protein 3 (1-8U)
    Hs.374650  [show with all ESTs]
    Unigene Representative Sequence: BF965170


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000399808  ENST00000270031  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IFITM3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IFITM3

    1 / 2 / 3

    4 probe-sets matching IFITM3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    41745_at2, 3 U95-A 5 1.00 0.63 0.99 0.99 X57352 1.00 1.00 1.00 1

    676_g_at2, 3 U95-A 10 1.00 0.22 0.99 1.01 J04164 0.20 0.05 0.15 3

    212203_x_at2, 3 U133-A 8 1.00 0.48 -- -- BF338947 0.60 1.00 0.82 1

    212203_x_at2 U133Plus2 8 1.00 0.48 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCTGTATCC

    SOURCE GeneReport for Unigene cluster: Hs.374650

    Expression variation in blood from EXPOLDB for IFITM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for IFITM3 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    IFITM31   -- interferon induced transmembrane protein 3 (1-8U) 98.75(n)
    99.25(a)
    738726  XM_001145216.1  XP_001145216.1 
    cow
    (Bos taurus)
    IFITM11   -- interferon induced transmembrane protein 1 (9-27) 81.52(n)
    74.55(a)
    353510  NM_174551.2  NP_776976.1 
    rat
    (Rattus norvegicus)
    Ifitm31   -- interferon induced transmembrane protein 3 73.7(n)
    71.09(a)
    361673  XM_341957.2  XP_341958.1 
    mouse
    (Mus musculus)
    Ifitm31, 5 75
    interferon induced transmembrane protein 31, 5 73.96(n)1
    70.31(a)1
    661411  NM_025378.21  NP_079654.11 
     AK0034075  AK0079165  (see all 12)
    About this table        Species with no ortholog for IFITM3

    ENSEMBL Gene Tree for IFITM3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IFITM3 gene
    IFITM12  ENSG000001880822  IFITM52  IFITM22  IFITM8P2  

    Pseudogenes
    10 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/62 NCBI SNPs in IFITM3 are shown (see all 62 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 15)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs11368531,2
    C,F,H310805(-) AATCAC/AACTGT 1 Q/H mis15Minor allele frequency- A:0.04MN EU EA WA 600
    --
    rs38881881,2
    A,C311017(-) CCTCTG/TAGCCC 1 -- ng310--------
    --
    rs65980451,2
    A,C311001(-) CCCTCC/TTTCCT 1 -- ng31 trp30--------
    --
    rs74787281,2
    A,C310994(-) TCCTCC/TCTATC 1 -- ng31 tfbs3 trp30--------
    --
    rs74792671,2
    A,C310988(-) CTATCC/TTAAAG 1 -- ng31 trp30--------
    --
    rs107943071,2
    A,C312722(+) AAACTC/TATTCC 1 -- ng31 tfbs30--------
    --
    rs73966841,2
    A311540(-) aaggtA/Tatggg 1 -- ng310--------
    rs109021221,2
    C311239(+) CGCCGC/TGGCTC 1 -- ng310--------
    --
    rs73970031,2
    A311550(-) caccaC/Tagtga 1 -- ng310--------
    --
    rs74786971,2
    A311104(-) GAGACC/TCCCAA 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for IFITM3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605579

    1 PharmGKB disease relationship for IFITM3 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for IFITM3 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10410 HGNC: 5414 AceView: IFITM3 Ensembl:ENSG00000142089 euGenes: HUgn10410
    ECgene: IFITM3 H-InvDB: IFITM3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IFITM3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFITM3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for IFITM3 Antibodies for IFITM3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for IFITM3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Search OriGene for IFITM3
     Search Tocris compounds for IFITM3




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     Antibodies for IFITM3

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