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Aliases & Descriptions for IFITM3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 1-8U 1, 2 | | IP15 2 | | interferon-inducible 2 |
| | | Descriptions |
|---|
| Interferon-inducible protein 1-8U 3 | | interferon induced transmembrane protein 3 (1-8U) 2 | | interferon-induced transmembrane protein 3 (1-8U) 2 |
|
| | Search outside databases for aliases for IFITM3 genePrevious GC identifers: GC11U990191 GC08P9A0176 GC11P000877 |
Summaries for IFITM3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for IFITM3 |
Genomic Location for IFITM3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFITM3 gene 
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5IFITM3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M000309:
(about GC identifiers)
Start:
|
309,673 bp from pter |
End:
|
310,914 bp from pter |
Size:
|
1,242 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_035113.6
| Proteins for IFITM3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628 (See
protein sequence)Recommended Name: Interferon-induced transmembrane protein 3 Size: 133 amino acids; 14632 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q96HK8 Q96J15Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_066362.2
ENSEMBL proteins: ENSP00000382707 ENSP00000372047
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IFITM3: Assays for IFITM3: | Protein
Domains/ Families for IFITM3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q01628
ProtoNet protein and cluster: Q01628 1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein
UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628Similarity: Belongs to the CD225 family | Gene Function for IFITM3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021034
Applied Biosystems Silencer® siRNAs for IFITM3
Sigma-Aldrich siRNA for IFITM3  Sigma-Aldrich shRNA for IFITM3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021034                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021034                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021034 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021034
UniProtKB/Swiss-Prot: IFM3_HUMAN, Q01628Induction: By alpha and gamma interferons2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ifitm3):
| Pathways & Interactions for IFITM3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for IFITM3 
1 Interacting protein for IFITM3 (Q016282) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for IFITM3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFITM3
|
Transcripts for IFITM3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021034
Sigma-Aldrich siRNA for IFITM3  Sigma-Aldrich shRNA for IFITM3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021034 REFSEQ mRNAs for IFITM3 gene: NM_021034.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021034               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021034                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021034                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021034  Additional cDNA sequence: AK292173.1 BC006794.1 BC008417.1 BC022439.1 BC070243.1 BT006892.1 CR611877.1 X57352.1 22 DOTS entries: DT.91775643 DT.91775637 DT.95297793 DT.95164281 DT.95164279 DT.120685634 DT.91819285 DT.100866643 DT.121113555 DT.98131772 DT.100640234 DT.100687220 DT.100687374 DT.120685623 DT.120685627 DT.120685646 DT.121232294 DT.86996321 DT.87017823 DT.95164232 DT.121113556 DT.86855828 24/929 AceView cDNA sequences (see all 929
):AA303810 BU521278 CB126237 CB111016 BQ677873 BM768624 AI754997 BQ477496 CD108602 CF995470 CA431735 BQ574611 BE787087 BM927811 AA320471 AA410248 CN480937 CA428023 AI870213 BM810730 AA340840 CA428710 BI254033 AA303697
highest scoring ESTs for IFITM3:X57352 AA057643 AA074734 AA090345 AA094193 AA100966 AA102576 AA186840 AA304206 AA309081 Unigene Cluster for IFITM3: Interferon induced transmembrane protein 3 (1-8U) Hs.374650 [show with all ESTs]Unigene Representative Sequence: BF965170
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000399808
ENST00000270031
|
Expression for IFITM3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFITM3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFITM3
1 / 2 / 3 4 probe-sets matching IFITM3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCTGTATCC
SOURCE GeneReport for Unigene cluster: Hs.374650
Expression variation in blood from EXPOLDB for IFITM3 |
Orthologs for IFITM3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFITM3 gene from 4 species
About this table Species with no ortholog for IFITM3
ENSEMBL Gene Tree for IFITM3 | Paralogs for IFITM3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFITM3 gene
- IFITM12 ENSG000001880822 IFITM52 IFITM22 IFITM8P2
Pseudogenes
- 10 related pseudogenes
|
SNPs/Variants for IFITM3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFITM3 (up to first 250kb)
|
Disorders & Mutations for IFITM3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605579
1 PharmGKB disease relationship for IFITM3 geneAbout this table
|
Medical News for IFITM3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFITM3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for IFITM3 gene (see all 15
): |
Search for IFITM3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFITM3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFITM3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFITM3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFITM3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFITM3:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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