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IFITM2 Gene

protein-coding   GIFtS: 56
GCID: GC11P000300

Interferon Induced Transmembrane Protein 2

(Previous name: interferon induced transmembrane protein 2 (1-8D))
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Induced Transmembrane Protein 21 2     Interferon Induced Transmembrane Protein 2 (1-8D)1
Dispanin Subfamily A Member 2c2 3     1-8D2
Interferon-Inducible Protein 1-8D2 3     Interferon-Induced Transmembrane Protein 22
DSPA2c2 3     

External Ids:    HGNC: 54131   Entrez Gene: 105812   Ensembl: ENSG000001852017   OMIM: 6055785   UniProtKB: Q016293   

Export aliases for IFITM2 gene to outside databases

Previous GC identifers: GC11P000530 GC11P000351 GC11M000889 GC11P000298 GC11P000299 GC11P000127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFITM2 Gene:
IFITM2 (interferon induced transmembrane protein 2) is a protein-coding gene. Diseases associated with IFITM2 include cycloplegia, and choroid cancer. An important paralog of this gene is IFITM1.

UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV
and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral
entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IFITM2 gene promoter:
         Elk-1   STAT1   deltaCREB   STAT3   ZID   Tal-1beta   E47   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFITM2 promoter sequence
   Search Chromatin IP Primers for IFITM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFITM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000300:  view genomic region     (about GC identifiers)

Start:
307,631 bp from pter      End:
315,272 bp from pter
Size:
7,642 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 2  
Size: 132 amino acids; 14632 Da
Subunit: Interacts with CD81 (By similarity)
Secondary accessions: Q6FH82 Q96DA8

Explore the universe of human proteins at neXtProt for IFITM2: NX_Q01629

Explore proteomics data for IFITM2 at MOPED

Post-translational modifications: 

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    against influenza virus (By similarity)1
  • Ubiquitination2 at Lys87
  • Modification sites at PhosphoSitePlus

  • See IFITM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006426.2  
    ENSEMBL proteins: 
     ENSP00000434443   ENSP00000382714   ENSP00000473587   ENSP00000431850   ENSP00000382712  
    Reactome Protein details: Q01629

    IFITM2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IFITM2
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    Novus Biologicals IFITM2 Proteins
    Novus Biologicals IFITM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFITM2

    IFITM2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IFITM2 Antibodies
    Abcam antibodies for IFITM2
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    ThermoFisher Antibodies for IFITM2
    LSBio Antibodies in human, mouse, rat for IFITM2

    IFITM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFITM2
    Cloud-Clone Corp. CLIAs for IFITM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007593 CD225/Dispanin_fam

    Graphical View of Domain Structure for InterPro Entry Q01629

    ProtoNet protein and cluster: Q01629

    1 Blocks protein domain: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629
    Similarity: Belongs to the CD225/Dispanin family


    IFITM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFM2_HUMAN, Q01629
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
    against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
    virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
    vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV
    and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral
    entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner
    Induction: By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53

    Phenotypes:
         1 GenomeRNAi human phenotype for IFITM2:

     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFITM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFITM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFITM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFITM2

    miRNA
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    Block miRNA regulation of human, mouse, rat IFITM2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM2
    SwitchGear 3'UTR luciferase reporter plasmidIFITM2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IFITM2
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM2

    Gene Editing
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    OriGene ORF clones in mouse, rat for IFITM2
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    GenScript: all cDNA clones in your preferred vector: IFITM2 (NM_006435)
    Sino Biological Human cDNA Clone for IFITM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFITM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFM2_HUMAN, Q01629: Cell membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    IFITM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFITM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IFITM2
        Interferon alpha/beta signaling



    IFITM2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFITM2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFITM2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IFITM2 (Q016292, 3 ENSP000003827144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCD3Q96EY72, 3, ENSP000002546304MINT-64363 I2D: score=3 STRING: ENSP00000254630
    UPF3AQ9H1J13, ENSP000003644484I2D: score=4 STRING: ENSP00000364448
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1906403
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0034341response to interferon-gamma IDA--

    IFITM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFITM2 (IFM2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IFITM2 gene: 
    NM_006435.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533141 ENST00000399817(uc001lox.4) ENST00000602569 ENST00000527146
    ENST00000399815
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFITM2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM2
    SwitchGear 3'UTR luciferase reporter plasmidIFITM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFITM2
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM2
    Clone
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    OriGene ORF clones in mouse, rat for IFITM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM2 (NM_006435)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFITM2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFITM2
      QuantiTect SYBR Green Assays in human, mouse, rat IFITM2
      QuantiFast Probe-based Assays in human, mouse, rat IFITM2

    Selected AceView cDNA sequences (see all 991):

    BM670465 AA702139 AA293127 BG832111 AA302184 R53017 BG502912 AA602763 
    R52262 CR604902 BG218401 CD622664 BG504643 AI280158 BM767351 BF437232 
    BU630740 AA299136 BF104076 BQ447972 BG194579 AW574932 AJ714659 BM672752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFITM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTCTGC
    IFITM2 Expression
    About this image


    IFITM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    IFITM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFITM2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFITM2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IFITM2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFITM2
    QuantiTect SYBR Green Assays in human, mouse, rat IFITM2
    QuantiFast Probe-based Assays in human, mouse, rat IFITM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFITM2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifitm21 , 5 interferon induced transmembrane protein 21, 5 75(n)1
    66.67(a)1
      7 (86.18 cM)5
    808761  NM_030694.11  NP_109619.11 
     1409548395 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    35(a)
    1 → many
    5(1592827-1594156) ENSGALG00000026970
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-226m8.76
    si:dkey-226m8.7
    30(a)
    many ↔ many
    5(34876187-34876977) ENSDARG00000093303


    ENSEMBL Gene Tree for IFITM2 (if available)
    TreeFam Gene Tree for IFITM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFITM2 gene
    IFITM12  IFITM32  IFITM52  IFITM102  ENSG000002506442  
    4 SIMAP similar genes for IFITM2 using alignment to 5 protein entries:     IFM2_HUMAN (see all proteins):
    IFITM3    IFITM1    IFITM5    IFITM10

    IFITM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFITM2 (see all 181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813254731,2
    --306126(+) GTGCCC/TAAACT 1 -- us2k10--------
    rs1475235541,2
    C--306127(+) TGCCTA/GAACTC 1 -- us2k10--------
    rs733965801,2
    C,F--306163(+) TGTCCG/AACCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs71289141,2
    C,F--306216(-) aggggG/Ttccca 1 -- us2k12Minor allele frequency- T:0.06WA EA 238
    rs1858165371,2
    --306267(+) CTTAGA/GTTTTT 1 -- us2k10--------
    rs1455160111,2
    --306366(+) AGATCC/TCAGGA 1 -- us2k10--------
    rs1906182151,2
    --306462(+) CAGCAA/GAAGGA 1 -- us2k10--------
    rs1509654701,2
    --306494(+) GTCGAC/GAAGCA 1 -- us2k10--------
    rs793525461,2
    F--306582(+) TATAGA/CGCCAA 1 -- us2k10--------
    rs728677341,2
    C--306742(+) CTCAGC/TGATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFITM2 (307631 - 315272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IFITM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv916n71CNV Loss21882294
    dgv915n71CNV Loss21882294
    nsv527327CNV Loss19592680
    dgv913n71CNV Loss21882294
    nsv896447CNV Loss21882294
    dgv917n71CNV Loss21882294
    dgv914n71CNV Loss21882294
    dgv911n71CNV Gain21882294
    nsv896463CNV Gain21882294
    nsv7212OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFITM2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFITM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605578    OMIM disorders: --

    19 diseases for IFITM2:    
    About MalaCards
    cycloplegia    choroid cancer    corneal ectasia    anisometropia
    west nile virus    hyperopia    rift valley fever    astigmatism
    choroiditis    stomatitis    keratoconus    myopia
    influenza    inflammatory bowel disease    hiv-1    adenoma
    ovarian cancer    colorectal cancer    cervicitis

    6 diseases from the University of Copenhagen DISEASES database for IFITM2:
    Astigmatism     Myopia     Cycloplegia     Anisometropia
    Hyperopia     Keratoconus

    IFITM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IFITM2
    Human Genome Epidemiology (HuGE) Navigator: IFITM2 (1 document)

    Export disorders for IFITM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFITM2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with IFITM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of a human interferon-inducible gene family. (PubMed id 1906403)1, 2, 3, 9 Lewin A.R.... Kerr I.M. (Eur. J. Biochem. 1991)
    2. The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. (PubMed id 19544527)1, 2, 9 Daniel-Carmi V.... Eisenbach L. (Int. J. Cancer 2009)
    3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)1, 2 Sallman Almen M.... Schioth H.B. (PLoS ONE 2012)
    4. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J.... Liang C. (J. Virol. 2011)
    5. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. (PubMed id 20534863)1, 2 Jiang D.... Guo J.T. (J. Virol. 2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins. (PubMed id 23376165)1 Chutiwitoonchai N....Suzu S. (Microbes Infect. 2013)
    9. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. (PubMed id 23720721)1 Mudhasani R....Bavari S. (J. Virol. 2013)
    10. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. (PubMed id 22479637)2 Chan Y.K.... Farzan M. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10581 HGNC: 5413 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185201 euGenes: HUgn10581
    ECgene: IFITM2 H-InvDB: IFITM2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFITM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for IFITM2 gene:
    Search GeneIP for patents involving IFITM2

    GeneCards and IP:
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