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Aliases for IFITM2 Gene

Aliases for IFITM2 Gene

  • Interferon Induced Transmembrane Protein 2 2 3
  • Interferon-Inducible Protein 1-8D 3 4
  • Dispanin Subfamily A Member 2c 3 4
  • DSPA2c 3 4
  • Interferon Induced Transmembrane Protein 2 (1-8D) 2
  • Interferon-Induced Transmembrane Protein 2 3
  • 1-8D 3

External Ids for IFITM2 Gene

Summaries for IFITM2 Gene

GeneCards Summary for IFITM2 Gene

IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with IFITM2 include cycloplegia and anisometropia. Among its related pathways are Interferon Signaling and Interferon Signaling. An important paralog of this gene is IFITM1.

UniProtKB/Swiss-Prot for IFITM2 Gene

  • IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM2 Gene

Genomics for IFITM2 Gene

Genomic Location for IFITM2 Gene

Start:
307,631 bp from pter
End:
315,272 bp from pter
Size:
7,642 bases
Orientation:
Plus strand

Genomic View for IFITM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFITM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM2 Gene

Regulatory Elements for IFITM2 Gene

Proteins for IFITM2 Gene

  • Protein details for IFITM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01629-IFM2_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 2
    Protein Accession:
    Q01629
    Secondary Accessions:
    • Q6FH82
    • Q96DA8

    Protein attributes for IFITM2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14632 Da
    Quaternary structure:
    • Interacts with CD81.

neXtProt entry for IFITM2 Gene

Proteomics data for IFITM2 Gene at MOPED

Post-translational modifications for IFITM2 Gene

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys87

Other Protein References for IFITM2 Gene

No data available for DME Specific Peptides for IFITM2 Gene

Domains for IFITM2 Gene

Protein Domains for IFITM2 Gene

UniProtKB/Swiss-Prot:

IFM2_HUMAN
Family:
  • Belongs to the CD225/Dispanin family.:
    • Q01629
genes like me logo Genes that share domains with IFITM2: view

No data available for Gene Families for IFITM2 Gene

Function for IFITM2 Gene

Molecular function for IFITM2 Gene

UniProtKB/Swiss-Prot Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.
UniProtKB/Swiss-Prot Induction: By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53.

Phenotypes for IFITM2 Gene

GenomeRNAi human phenotypes for IFITM2:
genes like me logo Genes that share phenotypes with IFITM2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFITM2 Gene

Localization for IFITM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFITM2 Gene COMPARTMENTS Subcellular localization image for IFITM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM2: view

Pathways for IFITM2 Gene

genes like me logo Genes that share pathways with IFITM2: view

Pathways by source for IFITM2 Gene

Interacting Proteins for IFITM2 Gene

Gene Ontology (GO) - Biological Process for IFITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1906403
GO:0009607 response to biotic stimulus --
GO:0009615 response to virus IDA 20943977
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0034341 response to interferon-gamma IDA 21253575
genes like me logo Genes that share ontologies with IFITM2: view

Transcripts for IFITM2 Gene

Unigene Clusters for IFITM2 Gene

Interferon induced transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM2 Gene

No ASD Table

Relevant External Links for IFITM2 Gene

GeneLoc Exon Structure for
IFITM2
ECgene alternative splicing isoforms for
IFITM2

Expression for IFITM2 Gene

mRNA expression in normal human tissues for IFITM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFITM2 Gene

This gene is overexpressed in Whole Blood (28.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFITM2 Gene

SOURCE GeneReport for Unigene cluster for IFITM2 Gene Hs.709321

genes like me logo Genes that share expressions with IFITM2: view

Orthologs for IFITM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM2 36
  • 97.98 (n)
  • 97.73 (a)
IFITM2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm2840 37
  • 53 (a)
ManyToMany
Gm7676 37
  • 55 (a)
ManyToMany
Ifitm1 37
  • 63 (a)
ManyToMany
Ifitm2 36
  • 75 (n)
  • 66.67 (a)
Ifitm2 16
Ifitm2 37
  • 58 (a)
ManyToMany
Ifitm3 37
  • 61 (a)
ManyToMany
Ifitm7 37
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifitm2 36
  • 77.24 (n)
  • 67.48 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 37
  • 30 (a)
ManyToMany
Species with no ortholog for IFITM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM2 Gene

ENSEMBL:
Gene Tree for IFITM2 (if available)
TreeFam:
Gene Tree for IFITM2 (if available)

Paralogs for IFITM2 Gene

Paralogs for IFITM2 Gene

Selected SIMAP similar genes for IFITM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IFITM2: view

Variants for IFITM2 Gene

Sequence variations from dbSNP and Humsavar for IFITM2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10398 -- 308,180(+) CGACC(A/G)CCGCT utr-variant-5-prime
rs13364 -- 309,208(+) GACCT(A/G)TATCC utr-variant-3-prime
rs14320 -- 309,042(+) GACGT(G/T)ACCGG reference, synonymous-codon
rs14408 - 308,314(+) CCCGA(C/T)GTCCA missense, reference
rs741738 -- 309,508(+) gcggc(A/G)agtga downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFITM2 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
nsv896447 CNV Loss 21882294
dgv913n71 CNV Loss 21882294
dgv914n71 CNV Loss 21882294
dgv915n71 CNV Loss 21882294
nsv7212 OTHER Inversion 18451855
dgv916n71 CNV Loss 21882294
dgv917n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680

Relevant External Links for IFITM2 Gene

HapMap Linkage Disequilibrium report
IFITM2

Disorders for IFITM2 Gene

(6) University of Copenhagen DISEASES for IFITM2 Gene

Relevant External Links for IFITM2

Genetic Association Database (GAD)
IFITM2
Human Genome Epidemiology (HuGE) Navigator
IFITM2
genes like me logo Genes that share disorders with IFITM2: view

No data available for UniProtKB/Swiss-Prot for IFITM2 Gene

Publications for IFITM2 Gene

  1. Molecular analysis of a human interferon-inducible gene family. (PMID: 1906403) Lewin A.R. … Kerr I.M. (Eur. J. Biochem. 1991) 2 3 4 23
  2. The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. (PMID: 19544527) Daniel-Carmi V. … Eisenbach L. (Int. J. Cancer 2009) 3 4 23
  3. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. (PMID: 20534863) Jiang D. … Guo J.T. (J. Virol. 2010) 3 4
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 49
  5. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. (PMID: 20943977) Weidner J.M. … Guo J.T. (J. Virol. 2010) 3 4

Products for IFITM2 Gene

Sources for IFITM2 Gene

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