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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFITM2 Gene

protein-coding   GIFtS: 55
GCID: GC11P000300

interferon induced transmembrane protein 2

(Previous name: interferon induced transmembrane protein 2 (1-8D) )
 Explore 18 diseases affiliated with
IFITM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IFITM2    

Aliases
for IFITM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interferon Induced Transmembrane Protein 21 2     DSPA2c2 3
1-8D1 2     Interferon Induced Transmembrane Protein 2 (1-8D)1
Dispanin Subfamily A Member 2c2 3     Interferon-Induced Transmembrane Protein 22
Interferon-Inducible Protein 1-8D2 3     

External Ids:    HGNC: 54131   Entrez Gene: 105812   Ensembl: ENSG000001852017   OMIM: 6055785   UniProtKB: Q016293   

Export aliases for IFITM2 gene to outside databases

Previous GC identifers: GC11P000530 GC11P000351 GC11M000889 GC11P000298 GC11P000299 GC11P000127


Summaries
for IFITM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against
multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV),
Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus
(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral
entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and
mediates apoptosis by caspase activation and in p53-independent manner




Genomic Views
for IFITM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFITM2 gene promoter:
         Elk-1   STAT1   deltaCREB   STAT3   ZID   Tal-1beta   E47   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFITM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFITM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000300:  view genomic region     (about GC identifiers)

Start:
 307,631 bp from pter      End:
 315,272 bp from pter
Size:
 7,642 bases      Orientation:
 plus strand

Proteins
for IFITM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 2  
Size: 132 amino acids; 14632 Da
Subunit: Interacts with CD81 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6FH82 Q96DA8

Explore the universe of human proteins at neXtProt for IFITM2: NX_Q01629

Post-translational modifications:

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    • against influenza virus (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01629

    • IFITM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006426.2  
    ENSEMBL proteins: 
     ENSP00000434443   ENSP00000382714   ENSP00000431850   ENSP00000382712  
    Reactome Protein details: Q01629
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: IFITM2
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    Novus Biologicals IFITM2 Proteins
    Novus Biologicals IFITM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IFITM2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    IFITM2 for ontologies           About GeneDecksing



    IFITM2 Antibody Products: 
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    ThermoFisher Antibodies for IFITM2

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    Uscn ELISAs and CLIAs for IFITM2

    Protein Domains /
    Families
    for IFITM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IFITM2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007593 Interferon-induced_TM_protein

    Graphical View of Domain Structure for InterPro Entry Q01629

    ProtoNet protein and cluster: Q01629

    1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629
    Similarity: Belongs to the CD225/Dispanin family


    Function
    for IFITM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IFM2_HUMAN, Q01629
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against
    multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV),
    Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus
    (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral
    entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and
    mediates apoptosis by caspase activation and in p53-independent manner
    Induction: By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFITM2
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    SwitchGear 3'UTR luciferase reporter plasmid: IFITM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFITM2 (see all 4)
    OriGene shRNA RFP: IFITM2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IFITM2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFITM2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: IFITM2 (NM_006435)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM2 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFITM2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFITM2

    1 GenomeRNAi human phenotype for IFITM2:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for IFITM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    2Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    3Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for IFITM2
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes
    Interferon Signaling
    Immune System



    IFITM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFITM2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IFITM2 (Q016291, 2, 3 ENSP000003827144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF3AQ9H1J11, 3, ENSP000003644484EBI-373124,EBI-521530 I2D: score=4 STRING: ENSP00000364448
    PTCD3Q96EY72, 3, ENSP000002546304MINT-64363 I2D: score=3 STRING: ENSP00000254630
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1906403
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0034341response to interferon-gamma IDA--


    IFITM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IFITM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFITM2
    Search CenterWatch for drugs/clinical trials and news about IFITM2 / IFM2 

    Transcripts
    for IFITM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IFITM2 gene: 
    NM_006435.2  

    Unigene Cluster for IFITM2:

    Interferon induced transmembrane protein 2
    Hs.709321  [show with all ESTs]
    Unigene Representative Sequence: BF965144
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533141 ENST00000399817(uc001lox.4) ENST00000527146 ENST00000399815


    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: IFITM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFITM2 (see all 4)
    OriGene shRNA RFP: IFITM2
    OriGene siRNA: IFITM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFITM2
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    GenScript: all cDNA clones in your preferred vector: IFITM2 (NM_006435)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFITM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM2

    Additional cDNA sequence: 

    BC009696.1 BT009859.1 CR456894.1 CR541874.1 X02490.1 X57351.1 

    22 DOTS entries:

    DT.92409790  DT.218787  DT.91728315  DT.87011450  DT.95164222  DT.100852475  DT.91775642  DT.92371726 
    DT.91775637  DT.92000975  DT.92008914  DT.100687374  DT.91775641  DT.91898740  DT.91904721  DT.95154133 
    DT.95164279  DT.100733427  DT.86855828  DT.91685940  DT.91775643  DT.95297793 

    24/991 AceView cDNA sequences (see all 991):

    AA702139 BM670465 BE877564 BG612707 BM672499 BM662200 AA379179 AA293127 
    BI908112 BM672752 CA420737 BU622201 AA985421 CD622669 AL697718 BG832111 
    BG504643 CD622664 CR604902 BG218401 R52262 BF437232 AA602763 BQ269618 

    GeneLoc Exon Structure


    Expression
    for IFITM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFITM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCATTCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IFITM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See IFITM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFITM2

    SOURCE GeneReport for Unigene cluster: Hs.709321
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFITM2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM2
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFITM2

    Orthologs
    for IFITM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for IFITM2 (if available)
    TreeFam Gene Tree for IFITM2 (if available) 

    Paralogs
    for IFITM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFITM2 gene
    IFITM12  IFITM52  IFITM32  IFITM102  
    4 SIMAP similar genes for IFITM2 using alignment to 5 protein entries:     IFM2_HUMAN (see all proteins):
    IFITM3    IFITM1    IFITM5    IFITM10

    IFITM2 for paralogs           About GeneDecksing



    Genomic Variants
    for IFITM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/136 NCBI SNPs in IFITM2 are shown (see all 136)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813254731,2
    		--306126(+) GTGCCC/TAAACT 1 -- us2k10--------
    rs1475235541,2
    		--306127(+) TGCCTA/GAACTC 1 -- us2k10--------
    rs733965801,2
    		C,--306163(+) TGTCCG/AACCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs71289141,2
    		C,F,--306216(-) aggggG/Ttccca 1 -- us2k12Minor allele frequency- T:0.06WA EA 238
    rs1858165371,2
    		--306267(+) CTTAGA/GTTTTT 1 -- us2k10--------
    rs1455160111,2
    		--306366(+) AGATCC/TCAGGA 1 -- us2k10--------
    rs1906182151,2
    		--306462(+) CAGCAA/GAAGGA 1 -- us2k10--------
    rs1509654701,2
    		--306494(+) GTCGAC/GAAGCA 1 -- us2k10--------
    rs793525461,2
    		--306582(+) TATAGA/CGCCAA 1 -- us2k10--------
    rs728677341,2
    		C,--306742(+) CTCAGC/TGATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFITM2 (307631 - 315272 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IFITM2
         1 Inversion: 37118

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFITM2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFITM2

    Disorders / Diseases
    for IFITM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IFITM2 for disorders           About GeneDecksing

    OMIM gene information: 605578    OMIM disorders: --

    18 diseases for IFITM2:    About MalaCards
    west nile virus    corneal ectasia    cycloplegia    anisometropia
    inflammatory bowel disease    hyperopia    astigmatism    keratoconus
    myopia    choroid cancer    cervical carcinoma    choroiditis
    cervicitis    ovarian cancer    influenza    colorectal cancer
    adenoma    carcinoma

    6 diseases from the University of Copenhagen DISEASES database for IFITM2:
    Astigmatism     Myopia     Cycloplegia     Anisometropia
    Hyperopia     Keratoconus
    Human Genome Epidemiology (HuGE) Navigator: IFITM2 (1 document)

    Export disorders for IFITM2 gene to outside databases

    Publications
    for IFITM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFITM2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with IFITM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of a human interferon-inducible gene family. (PubMed id 1906403)1, 2, 3, 9 Lewin A.R.... Kerr I.M. (1991)
    2. The human 1-8D gene (IFITM2) is a novel p53 independe nt pro-apoptotic gene. (PubMed id 19544527)1, 2, 9 Daniel-Carmi V....Eisenbach L. (2009)
    3. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J....Liang C. (2011)
    4. Identification of five interferon-induced cellular pr oteins that inhibit west nile virus and dengue virus infections. (PubMed id 20534863)1, 2 Jiang D....Guo J.T. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)2 Sallman Almen M.... Schioth H.B. (2012)
    7. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. (PubMed id 22479637)2 Chan Y.K.... Farzan M. (2012)
    8. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    9. Distinct patterns of IFITM-mediated restriction of fi loviruses, SARS coronavirus, and influenza A virus. (PubMed id 21253575)2 Huang I.C....Farzan M. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for IFITM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IFITM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10581 HGNC: 5413 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185201 euGenes: HUgn10581
    ECgene: IFITM2 H-InvDB: IFITM2

    Other Databases showing IFITM2 gene

    (According to HUGE)
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    Specialized Databases showing IFITM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFITM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for IFITM2 gene:
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