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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFITM10 Gene

protein-coding   GIFtS: 29
GCID: GC11M001755

Interferon Induced Transmembrane Protein 10

  Search for IFITM10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Induced Transmembrane Protein 101 2
Dispanin Subfamily A Member 32 3
DSPA32 3
Interferon-Induced Transmembrane Protein 102

External Ids:    HGNC: 400221   Entrez Gene: 4027782   Ensembl: ENSG000002442427   UniProtKB: A6NMD03   

Export aliases for IFITM10 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFITM10 Gene: 
IFITM10 (interferon induced transmembrane protein 10) is a protein-coding gene. An important paralog of this gene is IFITM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IFITM10
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001755:  view genomic region     (about GC identifiers)

Start:
1,753,640 bp from pter      End:
1,771,824 bp from pter
Size:
18,185 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFM10_HUMAN, A6NMD0 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 10  
Size: 228 amino acids; 24599 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Caution: It is uncertain whether Met-1 or Met-99 is the initiator
Sequence caution: Sequence=BAF82263.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NEU7

Explore the universe of human proteins at neXtProt for IFITM10: NX_A6NMD0

Explore proteomics data for IFITM10 at MOPED 

IFITM10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFITM10 Protein Expression

REFSEQ proteins: NP_001164291.2  
ENSEMBL proteins: 
 ENSP00000371557   ENSP00000344430  

Human Recombinant Protein Products for IFITM10: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

IFITM10 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR007593 Interferon-induced_TM_protein

Graphical View of Domain Structure for InterPro Entry A6NMD0

ProtoNet protein and cluster: A6NMD0

UniProtKB/Swiss-Prot: IFM10_HUMAN, A6NMD0
Similarity: Belongs to the CD225/Dispanin family


IFITM10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFITM10

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009607response to biotic stimulus IEA--

IFITM10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFITM10 (IFM10)

Search CenterWatch for drugs/clinical trials and news about IFITM10 / IFM10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFITM10 gene: 
NM_001170820.3  

Unigene Cluster for IFITM10:

Interferon induced transmembrane protein 10
Hs.121575  [show with all ESTs]
Unigene Representative Sequence: NM_001170820
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000382123 ENST00000340134(uc021qbs.1) ENST00000482459 ENST00000486852

miRNA
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Additional mRNA sequence: 

AK289574.1 BC036199.1 

7 DOTS entries:

DT.92042237  DT.91752367  DT.95317688  DT.108744  DT.100811877  DT.97838740  DT.91748895 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFITM10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGTTGGGGC
IFITM10 Expression
About this image


See IFITM10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFITM10

SOURCE GeneReport for Unigene cluster: Hs.121575
    SABiosciences Custom PCR Arrays for IFITM10
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifitm105 RIKEN cDNA 6330512M04 gene   --   7 (87.90 cM) 142325837 
chicken
(Gallus gallus)
Aves IFITM106
--
Uncharacterized protein
52(a)
34(a)
1 ↔ many
possible ortholog
5(13521166-13527643)
5(1596307-1597850)
lizard
(Anolis carolinensis)
Reptilia IFITM106
--
Uncharacterized protein
74(a)
37(a)
1 ↔ many
possible ortholog
1(70905680-70946365)
1(76990950-76998967)


ENSEMBL Gene Tree for IFITM10 (if available)
TreeFam Gene Tree for IFITM10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFITM10 gene
IFITM12  IFITM32  IFITM52  IFITM22  ENSG000002506442  
3 SIMAP similar genes for IFITM10 using alignment to 2 protein entries:     IFM10_HUMAN (see all proteins):
IFITM5    IFITM3    IFITM2

IFITM10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/439 SNPs in IFITM10 are shown (see all 439)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs573674171,2
C--1753243(+) ACACA-/CAGATGC 1 -- int10--------
rs1450563951,2
C--1753314(+) GATCC-/TTTA  
        
TTTAT
1 -- int10--------
rs96672331,2
C,F,A--1753340(+) ACAGGG/ATCTCA 1 -- int16Minor allele frequency- A:0.15NA WA CSA EA 247
rs96679151,2
C,F,A--1753345(+) GTCTCA/GCTCTG 1 -- int15Minor allele frequency- G:0.19NA WA CSA EA 127
rs1137415411,2
C,F--1753377(+) GGTGCA/GATCAC 1 -- int12Minor allele frequency- G:0.07NA EA 240
rs558019641,2
C--1753576(+) CTCCCC/AAAAGA 1 -- int17Minor allele frequency- A:0.30WA CSA NA EA 364
rs1117802231,2
C,F--1753625(+) GAGAGT/AGAGAG 1 -- int12Minor allele frequency- A:0.18CSA WA 120
rs616015701,2
C,F--1753756(+) AGGCAT/GGAGTA 1 -- ut317Minor allele frequency- G:0.29WA CSA NA EA 365
rs71215441,2
C,F--1753935(+) GGGGCC/TTTTGT 1 -- ut311Minor allele frequency- T:0.09WA 118
rs1885022761,2
--1753943(+) TGTAGC/TCCCAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for IFITM10 (1753640 - 1771824 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/12 variations for IFITM10 (see all 12):    About this table     
Variant IDTypeSubtypePubMed ID
esv2403037CNV Deletion18987734
nsv7642CNV Insertion18451855
nsv896736CNV Loss21882294
nsv896735CNV Loss21882294
nsv832049CNV Loss17160897
nsv896732CNV Loss21882294
nsv896733CNV Loss21882294
nsv896731CNV Loss21882294
nsv896734CNV Loss21882294
nsv467645CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFITM10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IFITM10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)2 Sallman Almen M.... Schioth H.B. (2012)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 402778 HGNC: 40022 Ensembl:ENSG00000244242 euGenes: HUgn402778 ECgene: IFITM10
H-InvDB: IFITM10

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IFITM10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IFITM10 gene:
Search GeneIP for patents involving IFITM10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for IFITM10
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for IFITM10
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFITM10
Customized:
 lentivirus for stable overexpression of IFITM10
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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