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Aliases for IFITM10 Gene

Aliases for IFITM10 Gene

  • Interferon Induced Transmembrane Protein 10 2 3 5
  • Dispanin Subfamily A Member 3 3 4
  • DSPA3 3 4
  • Interferon-Induced Transmembrane Protein 10 3

External Ids for IFITM10 Gene

Previous GeneCards Identifiers for IFITM10 Gene

  • GC11M001755

Summaries for IFITM10 Gene

GeneCards Summary for IFITM10 Gene

IFITM10 (Interferon Induced Transmembrane Protein 10) is a Protein Coding gene. An important paralog of this gene is IFITM3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM10 Gene

Genomics for IFITM10 Gene

Regulatory Elements for IFITM10 Gene

Enhancers for IFITM10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F001705 1.1 FANTOM5 22.6 +44.7 44671 0.4 ESRRA PKNOX1 DPF2 EP300 ZNF217 E2F1 RAD51 CTBP1 GATA3 RCOR1 IFITM10 KRTAP5-5 KRTAP5-6 GC11M001718
GH11F001767 1.5 FANTOM5 Ensembl ENCODE 17.9 -20.6 -20607 6.8 HDGF ATF1 PKNOX1 ARNT ZFP64 GATA2 FOS MCM3 YY2 NCOA1 IFITM10 TNNI2 SYT8 KRTAP5-6 LOC100505570 FAM99B RPL26P30 ENSG00000255142 LSP1 KCNQ1OT1
GH11F001748 0.6 FANTOM5 ENCODE 13.4 0.0 -25 4.8 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A GLIS2 FOS PAF1 IFITM10 RPL26P30 ENSG00000255142 KCNQ1OT1 ENSG00000235027 RPLP2
GH11F001810 0.5 Ensembl 11.9 -60.4 -60407 0.8 ARID4B KLF17 ZSCAN9 RAD21 ZNF48 ZNF335 GLIS2 ZNF143 THAP11 ZNF654 TNNI2 CTSD ENSG00000229512 ENSG00000250644 ENSG00000235027 IFITM10 MRPL23-AS1 LINC01219 H19 MIR675
GH11F001701 0.5 Ensembl 11.5 +49.5 49494 0.2 ZFHX2 RNF2 EGR2 ENSG00000235027 CTSD ENSG00000229512 ENSG00000250644 IFITM10 SYT8 TNNI2 KRTAP5-5 KRTAP5-6 GC11M001718
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFITM10 on UCSC Golden Path with GeneCards custom track

Promoters for IFITM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000557155 1794 1601 ESRRA TFAP4 PKNOX1 SUZ12 ZFP64 ZNF140 ZNF101 CTBP1 GATA3 FOS

Genomic Location for IFITM10 Gene

Chromosome:
11
Start:
1,732,410 bp from pter
End:
1,750,594 bp from pter
Size:
18,185 bases
Orientation:
Minus strand

Genomic View for IFITM10 Gene

Genes around IFITM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM10 Gene

Proteins for IFITM10 Gene

  • Protein details for IFITM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMD0-IFM10_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 10
    Protein Accession:
    A6NMD0
    Secondary Accessions:
    • A6NEU7

    Protein attributes for IFITM10 Gene

    Size:
    228 amino acids
    Molecular mass:
    24599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAF82263.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IFITM10 Gene

Post-translational modifications for IFITM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFITM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFITM10 Gene

Domains & Families for IFITM10 Gene

Protein Domains for IFITM10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFITM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMD0

UniProtKB/Swiss-Prot:

IFM10_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM10: view

No data available for Gene Families for IFITM10 Gene

Function for IFITM10 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFITM10 Gene

Localization for IFITM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFITM10 Gene COMPARTMENTS Subcellular localization image for IFITM10 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM10: view

Pathways & Interactions for IFITM10 Gene

SuperPathways for IFITM10 Gene

No Data Available

Interacting Proteins for IFITM10 Gene

Gene Ontology (GO) - Biological Process for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with IFITM10: view

No data available for Pathways by source and SIGNOR curated interactions for IFITM10 Gene

Transcripts for IFITM10 Gene

mRNA/cDNA for IFITM10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFITM10 Gene

Interferon induced transmembrane protein 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM10 Gene

No ASD Table

Relevant External Links for IFITM10 Gene

GeneLoc Exon Structure for
IFITM10
ECgene alternative splicing isoforms for
IFITM10

Expression for IFITM10 Gene

mRNA expression in normal human tissues for IFITM10 Gene

mRNA differential expression in normal tissues according to GTEx for IFITM10 Gene

This gene is overexpressed in Adrenal Gland (x6.9) and Artery - Aorta (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of IFITM10 Gene:

IFITM10

SOURCE GeneReport for Unigene cluster for IFITM10 Gene:

Hs.121575
genes like me logo Genes that share expression patterns with IFITM10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFITM10 Gene

Orthologs for IFITM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
LOC613464 34
  • 92.33 (n)
dog
(Canis familiaris)
Mammalia IFITM10 34
  • 91.71 (n)
-- 35
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifitm10 34
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifitm10 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFITM10 34
  • 79.02 (n)
-- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifitm10 34
  • 70.28 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 35
  • 26 (a)
ManyToMany
Species where no ortholog for IFITM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM10 Gene

ENSEMBL:
Gene Tree for IFITM10 (if available)
TreeFam:
Gene Tree for IFITM10 (if available)

Paralogs for IFITM10 Gene

Paralogs for IFITM10 Gene

(3) SIMAP similar genes for IFITM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFITM10: view

Variants for IFITM10 Gene

Sequence variations from dbSNP and Humsavar for IFITM10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1054634 -- 1,734,995(-) GTCTG(C/T)GTCCC utr-variant-3-prime
rs11040894 -- 1,738,812(+) tccca(C/G)cactt intron-variant
rs1105311 -- 1,742,183(-) ATCTC(A/G)TTGAC intron-variant
rs1105312 -- 1,741,793(-) CATAC(A/G)GGAAT intron-variant
rs111210480 -- 1,743,160(+) TGGAG(A/G)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFITM10 Gene

Variant ID Type Subtype PubMed ID
esv2403037 CNV deletion 18987734
esv3370062 CNV duplication 20981092
nsv1121470 CNV deletion 24896259
nsv1129154 CNV insertion 24896259
nsv1137983 CNV deletion 24896259
nsv1140466 CNV tandem duplication 24896259
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv7642 CNV insertion 18451855
nsv832049 CNV loss 17160897

Variation tolerance for IFITM10 Gene

Gene Damage Index Score: 2.08; 37.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFITM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM10 Gene

Disorders for IFITM10 Gene

Relevant External Links for IFITM10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFITM10

No disorders were found for IFITM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFITM10 Gene

Publications for IFITM10 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for IFITM10 Gene

Sources for IFITM10 Gene

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