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Aliases for IFITM10 Gene

Aliases for IFITM10 Gene

  • Interferon Induced Transmembrane Protein 10 2 3 5
  • Dispanin Subfamily A Member 3 3 4
  • DSPA3 3 4

External Ids for IFITM10 Gene

Previous GeneCards Identifiers for IFITM10 Gene

  • GC11M001755

Summaries for IFITM10 Gene

GeneCards Summary for IFITM10 Gene

IFITM10 (Interferon Induced Transmembrane Protein 10) is a Protein Coding gene. An important paralog of this gene is IFITM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM10 Gene

Genomics for IFITM10 Gene

Regulatory Elements for IFITM10 Gene

Promoters for IFITM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFITM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFITM10 Gene

Chromosome:
11
Start:
1,732,410 bp from pter
End:
1,750,594 bp from pter
Size:
18,185 bases
Orientation:
Minus strand

Genomic View for IFITM10 Gene

Genes around IFITM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM10 Gene

Proteins for IFITM10 Gene

  • Protein details for IFITM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMD0-IFM10_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 10
    Protein Accession:
    A6NMD0
    Secondary Accessions:
    • A6NEU7

    Protein attributes for IFITM10 Gene

    Size:
    228 amino acids
    Molecular mass:
    24599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAF82263.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IFITM10 Gene

Proteomics data for IFITM10 Gene at MOPED

Post-translational modifications for IFITM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFITM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFITM10 Gene

Domains & Families for IFITM10 Gene

Protein Domains for IFITM10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFITM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMD0

UniProtKB/Swiss-Prot:

IFM10_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM10: view

No data available for Gene Families for IFITM10 Gene

Function for IFITM10 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFITM10 Gene

Localization for IFITM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFITM10 Gene COMPARTMENTS Subcellular localization image for IFITM10 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IFITM10: view

Pathways & Interactions for IFITM10 Gene

SuperPathways for IFITM10 Gene

No Data Available

Interacting Proteins for IFITM10 Gene

Gene Ontology (GO) - Biological Process for IFITM10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFITM10 Gene

Drugs & Compounds for IFITM10 Gene

No Compound Related Data Available

Transcripts for IFITM10 Gene

mRNA/cDNA for IFITM10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFITM10 Gene

Interferon induced transmembrane protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM10 Gene

No ASD Table

Relevant External Links for IFITM10 Gene

GeneLoc Exon Structure for
IFITM10
ECgene alternative splicing isoforms for
IFITM10

Expression for IFITM10 Gene

mRNA expression in normal human tissues for IFITM10 Gene

mRNA differential expression in normal tissues according to GTEx for IFITM10 Gene

This gene is overexpressed in Adrenal Gland (x6.9) and Artery - Aorta (x4.2).

SOURCE GeneReport for Unigene cluster for IFITM10 Gene Hs.121575

genes like me logo Genes that share expression patterns with IFITM10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFITM10 Gene

Orthologs for IFITM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC613464 35
  • 92.33 (n)
  • 98 (a)
-- 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IFITM10 35
  • 91.71 (n)
  • 97.51 (a)
-- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifitm10 35
  • 88.83 (n)
  • 95.5 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifitm10 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFITM10 35
  • 79.02 (n)
  • 78.82 (a)
-- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifitm10 35
  • 70.28 (n)
  • 71.67 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 36
  • 26 (a)
ManyToMany
Species with no ortholog for IFITM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM10 Gene

ENSEMBL:
Gene Tree for IFITM10 (if available)
TreeFam:
Gene Tree for IFITM10 (if available)

Paralogs for IFITM10 Gene

Paralogs for IFITM10 Gene

(3) SIMAP similar genes for IFITM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFITM10: view

Variants for IFITM10 Gene

Sequence variations from dbSNP and Humsavar for IFITM10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs867573 -- 1,741,509(+) GCAAG(C/G)AAGGA intron-variant
rs939251 -- 1,742,429(-) CCTCC(C/T)TCCTC intron-variant
rs939252 -- 1,742,416(-) CCACC(C/T)TGTCT intron-variant
rs939253 -- 1,742,371(-) TTTTC(A/C)CTCTC intron-variant
rs1054634 -- 1,734,995(-) GTCTG(C/T)GTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFITM10 Gene

Variant ID Type Subtype PubMed ID
nsv896727 CNV Gain 21882294
nsv896728 CNV Gain 21882294
nsv832049 CNV Loss 17160897
nsv896731 CNV Loss 21882294
nsv896732 CNV Loss 21882294
nsv467645 CNV Gain 19166990
nsv896733 CNV Loss 21882294
esv2403037 CNV Deletion 18987734
nsv7642 CNV Insertion 18451855
nsv896734 CNV Loss 21882294
nsv896735 CNV Loss 21882294
nsv896736 CNV Loss 21882294

Variation tolerance for IFITM10 Gene

Gene Damage Index Score: 2.08; 37.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFITM10 Gene

HapMap Linkage Disequilibrium report
IFITM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM10 Gene

Disorders for IFITM10 Gene

Relevant External Links for IFITM10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFITM10

No disorders were found for IFITM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFITM10 Gene

Publications for IFITM10 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IFITM10 Gene

Sources for IFITM10 Gene

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