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IFITM10 Gene

protein-coding   GIFtS: 28
GCID: GC11M001755

Interferon Induced Transmembrane Protein 10

  Search for IFITM10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Induced Transmembrane Protein 101 2
Dispanin Subfamily A Member 32 3
DSPA32 3
Interferon-Induced Transmembrane Protein 102

External Ids:    HGNC: 400221   Entrez Gene: 4027782   Ensembl: ENSG000002442427   UniProtKB: A6NMD03   

Export aliases for IFITM10 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFITM10 Gene:
IFITM10 (interferon induced transmembrane protein 10) is a protein-coding gene. An important paralog of this gene is IFITM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  NT_187657.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IFITM10
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFITM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001755:  view genomic region     (about GC identifiers)

Start:
1,753,640 bp from pter      End:
1,771,824 bp from pter
Size:
18,185 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFM10_HUMAN, A6NMD0 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 10  
Size: 228 amino acids; 24599 Da
Caution: It is uncertain whether Met-1 or Met-99 is the initiator
Sequence caution: Sequence=BAF82263.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NEU7

Explore the universe of human proteins at neXtProt for IFITM10: NX_A6NMD0

Explore proteomics data for IFITM10 at MOPED


See IFITM10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001164291.2  
ENSEMBL proteins: 
 ENSP00000371557   ENSP00000344430  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007593 CD225/Dispanin_fam

Graphical View of Domain Structure for InterPro Entry A6NMD0

ProtoNet protein and cluster: A6NMD0

UniProtKB/Swiss-Prot: IFM10_HUMAN, A6NMD0
Similarity: Belongs to the CD225/Dispanin family


Find genes that share domains with IFITM10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFM10_HUMAN, A6NMD0: Cell membrane; Multi-pass membrane protein (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with IFITM10           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFITM10
Interactions:

    Search GeneGlobe Interaction Network for IFITM10

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009607response to biotic stimulus IEA--

Find genes that share ontologies with IFITM10           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFITM10 (IFM10)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IFITM10 gene: 
NM_001170820.3  

Unigene Cluster for IFITM10:

Interferon induced transmembrane protein 10
Hs.121575  [show with all ESTs]
Unigene Representative Sequence: NM_001170820
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000382123 ENST00000340134(uc021qbs.1) ENST00000482459 ENST00000486852

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hsa-miR-4303 hsa-miR-513a-5p hsa-miR-27a hsa-miR-765 hsa-miR-3921 hsa-miR-129-3p hsa-miR-27b hsa-miR-129*
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Additional mRNA sequence: 

AK289574.1 BC036199.1 

7 DOTS entries:

DT.92042237  DT.91752367  DT.95317688  DT.108744  DT.100811877  DT.97838740  DT.91748895 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFITM10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGTTGGGGC
IFITM10 Expression
About this image

IFITM10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFITM10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.121575
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifitm105 RIKEN cDNA 6330512M04 gene   --   7 (87.90 cM) 142325837 
chicken
(Gallus gallus)
Aves IFITM101 interferon induced transmembrane protein 10 79.02(n)
78.82(a)
  771148  XM_004941445.1  XP_004941502.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
74(a)
1 → many
1(70905680-70946365)
tropical clawed frog
(Xenopus tropicalis)
Amphibia ifitm101 interferon induced transmembrane protein 10 70.28(n)
71.67(a)
  100488476  XM_002938896.2  XP_002938942.1 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.76
si:dkey-226m8.7
26(a)
many ↔ many
5(34876187-34876977) ENSDARG00000093303


ENSEMBL Gene Tree for IFITM10 (if available)
TreeFam Gene Tree for IFITM10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFITM10 gene
IFITM12  IFITM32  IFITM52  IFITM22  ENSG000002506442  
3 SIMAP similar genes for IFITM10 using alignment to 2 protein entries:     IFM10_HUMAN (see all proteins):
IFITM5    IFITM3    IFITM2

Find genes that share paralogs with IFITM10           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFITM10 (see all 439)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs573674171,2
C--1753243(+) ACACA-/CAGATGC 1 -- int10--------
rs1450563951,2
C--1753314(+) GATCC-/TTTA  
        
TTTAT
1 -- int10--------
rs96672331,2
C,F,A--1753340(+) ACAGGG/ATCTCA 1 -- int16Minor allele frequency- A:0.15NA WA CSA EA 247
rs96679151,2
C,F,A--1753345(+) GTCTCA/GCTCTG 1 -- int15Minor allele frequency- G:0.19NA WA CSA EA 127
rs1137415411,2
C,F--1753377(+) GGTGCA/GATCAC 1 -- int12Minor allele frequency- G:0.07NA EA 240
rs558019641,2
C--1753576(+) CTCCCC/AAAAGA 1 -- int17Minor allele frequency- A:0.30WA CSA NA EA 364
rs1117802231,2
C,F--1753625(+) GAGAGT/AGAGAG 1 -- int12Minor allele frequency- A:0.18CSA WA 120
rs616015701,2
C,F--1753756(+) AGGCAT/GGAGTA 1 -- ut317Minor allele frequency- G:0.29WA CSA NA EA 365
rs71215441,2
C,F--1753935(+) GGGGCC/TTTTGT 1 -- ut311Minor allele frequency- T:0.09WA 118
rs1885022761,2
--1753943(+) TGTAGC/TCCCAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for IFITM10 (1753640 - 1771824 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IFITM10 (see all 12):    About this table    
Variant IDTypeSubtypePubMed ID
esv2403037CNV Deletion18987734
nsv7642CNV Insertion18451855
nsv896736CNV Loss21882294
nsv896735CNV Loss21882294
nsv832049CNV Loss17160897
nsv896732CNV Loss21882294
nsv896733CNV Loss21882294
nsv896731CNV Loss21882294
nsv896734CNV Loss21882294
nsv467645CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFITM10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IFITM10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)1, 2 Sallman Almen M.... Schioth H.B. (PLoS ONE 2012)
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 402778 HGNC: 40022 Ensembl:ENSG00000244242 euGenes: HUgn402778 ECgene: IFITM10
H-InvDB: IFITM10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFITM10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFITM10 gene:
Search GeneIP for patents involving IFITM10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse ESI BIO Cell Lines and PureStem Progenitors for IFITM10
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM10
 Browse SwitchGear 3'UTR luciferase reporter plasmids for IFITM10
 Browse SwitchGear Promoter luciferase reporter plasmids for IFITM10
 Search ThermoFisher Antibodies for IFITM10
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IFITM10
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFITM10
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFITM10
 Search LSBio for Antibodies for IFITM10
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for IFITM10
  Search eBioscience for proteins for IFITM10
  Search eBioscience for elisas for IFITM10
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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