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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFITM1 Gene

protein-coding   GIFtS: 62
GCID: GC11P000313

Interferon Induced Transmembrane Protein 1

(Previous name: interferon induced transmembrane protein 1 (9-27))
(Previous symbol: IFI17)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Induced Transmembrane Protein 11 2     CD2252 3
IFI171 2 3 5     DSPA2a2 3
Interferon-Induced Transmembrane Protein 11 2     LEU132 5
Dispanin Subfamily A Member 2a2 3     Interferon Induced Transmembrane Protein 1 (9-27)1
Interferon-Induced Protein 172 3     9-272
Interferon-Inducible Protein 9-272 3     CD225 Antigen3
Leu-13 Antigen2 3     

External Ids:    HGNC: 54121   Entrez Gene: 85192   Ensembl: ENSG000001858857   OMIM: 6044565   UniProtKB: P131643   

Export aliases for IFITM1 gene to outside databases

Previous GC identifers: GC11U990162 GC11M000883 GC11P000304 GC11P000303 GC11P000133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFITM1 Gene: 
IFITM1 (interferon induced transmembrane protein 1) is a protein-coding gene. Diseases associated with IFITM1 include west nile virus, and peutz-jeghers syndrome, and among its related super-pathways are Interferon Signaling and Immune System. GO annotations related to this gene include protein binding and receptor signaling protein activity. An important paralog of this gene is IFITM3.

UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV
GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and
control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by
inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a
positive regulator of osteoblast differentiation

Gene Wiki entry for IFITM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFITM1 gene promoter:
         GR   STAT1   Pax-5   STAT3   ZID   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFITM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000313:  view genomic region     (about GC identifiers)

Start:
313,506 bp from pter      End:
315,272 bp from pter
Size:
1,767 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 1  
Size: 125 amino acids; 13964 Da
Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation.
Interacts with CD81
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15322 Q53XZ0

Explore the universe of human proteins at neXtProt for IFITM1: NX_P13164

Explore proteomics data for IFITM1 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    against influenza virus (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13164

  • IFITM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFITM1 Protein Expression
    REFSEQ proteins: NP_003632.3  
    ENSEMBL proteins: 
     ENSP00000437057   ENSP00000330825   ENSP00000386187  
    Reactome Protein details: P13164
    Human Recombinant Protein Products for IFITM1: 
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    Novus Biologicals IFITM1 Proteins
    Novus Biologicals IFITM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFITM1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    IFITM1 for ontologies           About GeneDecksing



    IFITM1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for IFITM1 
    Cloud-Clone Corp. CLIAs for IFITM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR007593 Interferon-induced_TM_protein

    Graphical View of Domain Structure for InterPro Entry P13164

    ProtoNet protein and cluster: P13164

    1 Blocks protein domain: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Similarity: Belongs to the CD225/Dispanin family


    IFITM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFM1_HUMAN, P13164
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
    against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
    virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
    hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV
    GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and
    control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by
    inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a
    positive regulator of osteoblast differentiation
    Induction: By IFN-alpha and IFNG/IFN-gamma

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS7559564
    GO:0005515protein binding IPI2398277
         
    IFITM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFITM1:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ifitm1):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  reproductive system  skeleton 

    IFITM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFITM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFITM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFITM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFITM1 

    miRNA
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFITM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45
    4B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    5Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for IFITM1 (see all 6)
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Interferon Signaling
    Adaptive Immune System


    1         Kegg Pathway  (Kegg details for IFITM1):
        B cell receptor signaling pathway


    IFITM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFITM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for IFITM1 (P131641, 2, 3 ENSP000003861874) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958701, 2, 3, ENSP000003792824EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 STRING: ENSP00000379282
    ENSG00000236063O958701, 2, 3, ENSP000004069654EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 STRING: ENSP00000406965
    ENSG00000206403O958701, 2, 3EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    ENSG00000224552O958701, 2, 3EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    ENSG00000230475O958701, 2, 3EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0007166cell surface receptor signaling pathway TAS7559564
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--

    IFITM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFITM1 (IFM1)

    Search CenterWatch for drugs/clinical trials and news about IFITM1 / IFM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFITM1 gene: 
    NM_003641.3  

    Unigene Cluster for IFITM1:

    Interferon induced transmembrane protein 1
    Hs.458414  [show with all ESTs]
    Unigene Representative Sequence: BF210063
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528780 ENST00000328221 ENST00000408968(uc001loy.4) ENST00000525554

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFITM1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFITM1
    SwitchGear 3'UTR luciferase reporter plasmidIFITM1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM1

    Additional mRNA sequence: 

    AK290480.1 BC000897.1 BT007173.1 J04164.1 X84958.1 

    22 DOTS entries:

    DT.318215  DT.86855828  DT.92329365  DT.120756284  DT.95164236  DT.92409790  DT.97863531  DT.218787 
    DT.91728315  DT.91657632  DT.95164221  DT.91775643  DT.100687225  DT.120756268  DT.91775637  DT.91806015 
    DT.95164237  DT.95164274  DT.91775641  DT.91898740  DT.91904721  DT.92008914 

    24/991 AceView cDNA sequences (see all 991):

    BG504643 CD622664 BG218401 CR604902 R52262 BF437232 AA602763 BQ269618 
    AA302184 AI754120 BQ637680 BG502912 AA886388 R53017 BQ447972 BM767351 
    AA299136 BF104076 BG194579 AI280158 BU630740 BG504275 AW574932 AJ714659 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for IFITM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFITM1 expression in normal human tissues (normalized intensities)      IFITM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTGGAT
    IFITM1 Expression
    About this image


    IFITM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             BONE MARROW   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Sox17-GFP genetically modified stem cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Human Brain Vascular Pericyte (HBVP)   
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Pre-Granulosa Cells Primordial Follicle
             ovary ; follicle cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   

    See IFITM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFITM1

    SOURCE GeneReport for Unigene cluster: Hs.458414

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Tissue specificity: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal
    cancer and ovarian cancer. Expressed in glioma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including IFITM1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFITM1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifitm11 , 5 interferon induced transmembrane protein 11, 5 77.12(n)1
    65.69(a)1
      7 (86.20 cM)5
    687131  NM_001112715.11  NP_001106186.11 
     1409672215 
    chicken
    (Gallus gallus)
    Aves --
    --
    32(a)
    1 → many
    5(1592827-1594156)


    ENSEMBL Gene Tree for IFITM1 (if available)
    TreeFam Gene Tree for IFITM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFITM1 gene
    IFITM32  IFITM52  IFITM22  IFITM102  ENSG000002506442  
    3 SIMAP similar genes for IFITM1 using alignment to 1 protein entry:     IFM1_HUMAN:
    IFITM2    IFITM3    IFITM5

    IFITM1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IFITM1
    PGOHUM00000237578 PGOHUM00000249367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/95 SNPs in IFITM1 are shown (see all 95)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    VAR_0474224
    ----see VAR_0474222 P A mis40--------
    rs1148086271,2
    C,F--250051(+) CAGGCG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1855641431,2
    --250147(+) GAATCA/CTGTCT 1 -- us2k10--------
    rs775378471,2
    C--250149(+) ATCCTG/ATCTCC 1 -- us2k13Minor allele frequency- A:0.32CSA WA EA 240
    rs594132521,2
    C,F--250193(+) TGCCCG/ATGATT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs777592501,2
    C,F--250262(+) GATGTG/ATGGCC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1912053671,2
    --250373(+) CAGACA/GTAGTT 1 -- us2k10--------
    rs592747101,2
    C,F--250462(+) GCGATC/TTGGGG 1 -- us2k12Minor allele frequency- T:0.33WA CSA 3
    rs1440132191,2
    --250665(+) GGCTCA/GTCCTG 1 -- us2k10--------
    rs801863321,2
    C,F--250673(+) CTGCTA/GCAATT 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for IFITM1 (313506 - 315272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for IFITM1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527327CNV Loss19592680
    dgv917n71CNV Loss21882294
    dgv914n71CNV Loss21882294
    dgv915n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    nsv896447CNV Loss21882294
    nsv896463CNV Gain21882294
    dgv911n71CNV Gain21882294
    nsv499425OTHER Inversion21111241
    nsv513687OTHER Inversion21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604456    OMIM disorders: --

    19 diseases for IFITM1:    About MalaCards
    west nile virus    peutz-jeghers syndrome    cervical squamous cell carcinoma    esophageal cancer
    chronic myeloid leukemia    hepatitis c    influenza    esophagitis
    myeloid leukemia    squamous cell carcinoma    alcoholism    gastric cancer
    cervicitis    cervical cancer    ovarian cancer    hepatitis
    leukemia    colon cancer    breast cancer


    IFITM1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for IFITM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15506241 (1)

    Genetic Association Database (GAD): IFITM1
    Human Genome Epidemiology (HuGE) Navigator: IFITM1 (4 documents)

    Export disorders for IFITM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFITM1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with IFITM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. (PubMed id 7559564)1, 2, 3, 9 Deblandre G.A.... Wathelet M.G. (1995)
    2. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. (PubMed id 2398277)1, 2, 9 Takahashi S....Levy R. (1990)
    3. IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. (PubMed id 22634173)1, 2 Kim B.S.... You H.K. (2012)
    4. Distinct patterns of IFITM-mediated restriction of fi loviruses, SARS coronavirus, and influenza A virus. (PubMed id 21253575)1, 2 Huang I.C....Farzan M. (2011)
    5. Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. (PubMed id 20838853)1, 2 Yu F....Lin M.C. (2011)
    6. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J....Liang C. (2011)
    7. ISG56 and IFITM1 proteins inhibit hepatitis C virus r eplication. (PubMed id 21976647)1, 2 Raychoudhuri A....Ray R.B. (2011)
    8. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    10. The IFITM proteins mediate cellular resistance to inf luenza A H1N1 virus, West Nile virus, and dengue virus. (PubMed id 20064371)1, 2 Brass A.L....Elledge S.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8519 HGNC: 5412 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185885 euGenes: HUgn8519
    ECgene: IFITM1 Kegg: 8519 H-InvDB: IFITM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFITM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFITM1 gene:
    Search GeneIP for patents involving IFITM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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