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Aliases for IFITM1 Gene

Aliases for IFITM1 Gene

  • Interferon Induced Transmembrane Protein 1 2 3 5
  • Interferon-Induced Transmembrane Protein 1 2 3
  • Interferon-Inducible Protein 9-27 3 4
  • Dispanin Subfamily A Member 2a 3 4
  • Interferon-Induced Protein 17 3 4
  • Leu-13 Antigen 3 4
  • DSPA2a 3 4
  • IFI17 3 4
  • CD225 3 4
  • Interferon Induced Transmembrane Protein 1 (9-27) 2
  • CD225 Antigen 4
  • LEU13 3
  • 9-27 3

External Ids for IFITM1 Gene

Previous HGNC Symbols for IFITM1 Gene

  • IFI17

Previous GeneCards Identifiers for IFITM1 Gene

  • GC11U990162
  • GC11M000883
  • GC11P000304
  • GC11P000303
  • GC11P000133

Summaries for IFITM1 Gene

GeneCards Summary for IFITM1 Gene

IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus. Among its related pathways are Interferon gamma signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include signal transducer activity, downstream of receptor. An important paralog of this gene is IFITM3.

UniProtKB/Swiss-Prot for IFITM1 Gene

  • IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.

Gene Wiki entry for IFITM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM1 Gene

Genomics for IFITM1 Gene

Regulatory Elements for IFITM1 Gene


Enhancers around IFITM1 on UCSC Golden Path with GeneCards custom track

Promoters for IFITM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001765593 -506 401 POLR2A NR4A1 CUX1 ZNF584 IRF1

Genomic Location for IFITM1 Gene

Chromosome:
11
Start:
313,506 bp from pter
End:
315,272 bp from pter
Size:
1,767 bases
Orientation:
Plus strand

Genomic View for IFITM1 Gene

Genes around IFITM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM1 Gene

Proteins for IFITM1 Gene

  • Protein details for IFITM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13164-IFM1_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 1
    Protein Accession:
    P13164
    Secondary Accessions:
    • Q15322
    • Q53XZ0

    Protein attributes for IFITM1 Gene

    Size:
    125 amino acids
    Molecular mass:
    13964 Da
    Quaternary structure:
    • Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.

neXtProt entry for IFITM1 Gene

Post-translational modifications for IFITM1 Gene

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFITM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFITM1 (IFITM1)
  • Abcam antibodies for IFITM1

No data available for DME Specific Peptides for IFITM1 Gene

Domains & Families for IFITM1 Gene

Gene Families for IFITM1 Gene

Protein Domains for IFITM1 Gene

Suggested Antigen Peptide Sequences for IFITM1 Gene

Graphical View of Domain Structure for InterPro Entry

P13164

UniProtKB/Swiss-Prot:

IFM1_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM1: view

Function for IFITM1 Gene

Molecular function for IFITM1 Gene

UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for IFITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor TAS 7559564
GO:0005515 protein binding IPI 2398277
genes like me logo Genes that share ontologies with IFITM1: view

Phenotypes for IFITM1 Gene

genes like me logo Genes that share phenotypes with IFITM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IFITM1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFITM1 Gene

Localization for IFITM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM1 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
nucleus 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM1: view

Pathways & Interactions for IFITM1 Gene

genes like me logo Genes that share pathways with IFITM1: view

Gene Ontology (GO) - Biological Process for IFITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0002376 immune system process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 7559564
GO:0008285 negative regulation of cell proliferation IMP 20838853
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with IFITM1: view

No data available for SIGNOR curated interactions for IFITM1 Gene

Transcripts for IFITM1 Gene

Unigene Clusters for IFITM1 Gene

Interferon induced transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for IFITM1 Gene

GeneLoc Exon Structure for
IFITM1
ECgene alternative splicing isoforms for
IFITM1

Expression for IFITM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFITM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFITM1 Gene

This gene is overexpressed in Whole Blood (x10.0).

Protein differential expression in normal tissues from HIPED for IFITM1 Gene

This gene is overexpressed in Nasal epithelium (31.9), Breast (10.4), and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFITM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of IFITM1 Gene:

IFITM1

SOURCE GeneReport for Unigene cluster for IFITM1 Gene:

Hs.458414

mRNA Expression by UniProt/SwissProt for IFITM1 Gene:

P13164-IFM1_HUMAN
Tissue specificity: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.
genes like me logo Genes that share expression patterns with IFITM1: view

Primer Products

No data available for Protein tissue co-expression partners for IFITM1 Gene

Orthologs for IFITM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM1 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia IFITM1 34
  • 79.66 (n)
IFITM2 35
  • 69 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC475935 34
  • 74.1 (n)
-- 35
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ifitm1 35
  • 63 (a)
ManyToMany
Ifitm6 35
  • 54 (a)
ManyToMany
Ifitm3 35
  • 53 (a)
ManyToMany
Gm7676 35
  • 52 (a)
ManyToMany
Ifitm2 35
  • 52 (a)
ManyToMany
Ifitm7 35
  • 48 (a)
ManyToMany
Gm2840 35
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 35
  • 31 (a)
ManyToMany
Species where no ortholog for IFITM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM1 Gene

ENSEMBL:
Gene Tree for IFITM1 (if available)
TreeFam:
Gene Tree for IFITM1 (if available)

Paralogs for IFITM1 Gene

Paralogs for IFITM1 Gene

(3) SIMAP similar genes for IFITM1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFITM1 Gene

genes like me logo Genes that share paralogs with IFITM1: view

Variants for IFITM1 Gene

Sequence variations from dbSNP and Humsavar for IFITM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111407978 -- 314,867(+) CCATA(A/G)CACGC intron-variant
rs111634825 -- 315,169(+) TGCAC(A/G)CTGGG utr-variant-3-prime
rs111686812 -- 315,273(+) TGTGA(A/T)GATGC splice-donor-variant
rs11246062 -- 313,755(+) TGAAC(C/G)GGGAC upstream-variant-2KB
rs113041989 -- 314,672(+) CTTCC(A/G)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFITM1 Gene

Variant ID Type Subtype PubMed ID
nsv7212 OTHER inversion 18451855
nsv552765 CNV gain 21841781
nsv527327 CNV loss 19592680
nsv513688 OTHER inversion 21212237
nsv513687 OTHER inversion 21212237
nsv499425 OTHER inversion 21111241
nsv436656 OTHER inversion 17901297
nsv435976 OTHER inversion 17901297
esv3891905 CNV gain 25118596
esv2450457 OTHER inversion 19546169
dgv1505n54 CNV gain 21841781
dgv1012n100 CNV gain 25217958

Variation tolerance for IFITM1 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFITM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM1 Gene

Disorders for IFITM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IFITM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
west nile virus
  • west nile virus, susceptibility to
esophageal cancer
  • esophageal cancer, somatic
hepatitis c virus
  • hepatitic c virus
endometrial stromal nodule
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFITM1

Genetic Association Database (GAD)
IFITM1
Human Genome Epidemiology (HuGE) Navigator
IFITM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFITM1
genes like me logo Genes that share disorders with IFITM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFITM1 Gene

Publications for IFITM1 Gene

  1. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. (PMID: 7559564) Deblandre G.A. … Wathelet M.G. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. (PMID: 2398277) Takahashi S. … Levy R. (J. Immunol. 1990) 3 4 22 64
  3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 64
  4. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. (PMID: 22479637) Chan Y.K. … Farzan M. (PLoS ONE 2012) 3 4 64
  5. IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. (PMID: 22634173) Kim B.S. … You H.K. (Bone 2012) 3 4 64

Products for IFITM1 Gene

Sources for IFITM1 Gene

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