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Aliases & Descriptions for IFITM1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 9-27 1, 2 | | CD225 1, 2, 3 | | IFI17 2, 3, 5 | | LEU13 2, 5 |
| | | Descriptions |
|---|
| CD225 antigen 3 | | Interferon-induced protein 17 2, 3 | | Interferon-inducible protein 9-27 3 | | Leu-13 antigen 3 | | interferon induced transmembrane protein 1 (9-27) 2 |
|
| | Search outside databases for aliases for IFITM1 genePrevious GC identifers: GC11U990162 GC11M000883 GC11P000304 |
Summaries for IFITM1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164Function: Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signalsGene Wiki entry for IFITM1 |
Genomic Location for IFITM1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFITM1 gene 
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5IFITM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P000303:
(about GC identifiers)
Start:
|
301,317 bp from pter |
End:
|
305,272 bp from pter |
Size:
|
3,956 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_035113.6
| Proteins for IFITM1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164 (See
protein sequence)Recommended Name: Interferon-induced transmembrane protein 1 Size: 125 amino acids; 13964 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q15322REFSEQ proteins: NP_003632.3
ENSEMBL proteins: ENSP00000386187 ENSP00000330825 ENSP00000382712
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IFITM1: Assays for IFITM1: | Protein
Domains/ Families for IFITM1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P13164
ProtoNet protein and cluster: P13164 1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein
UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164Similarity: Belongs to the CD225 family | Gene Function for IFITM1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003641
Applied Biosystems Silencer® siRNAs for IFITM1
Sigma-Aldrich siRNA and siRNA Panels for IFITM1  Sigma-Aldrich shRNA for IFITM1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003641                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003641                                  untagged cDNA clone in CMV expression vector: NM_003641 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003641
UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164Function: Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signalsInduction: By alpha and gamma interferons2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for IFITM1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for IFITM1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for IFITM1 
3 Interacting proteins for IFITM1 (P131641, 2) via UniProtKB, MINT, and/or STRING| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ENSG00000096467 | O958701, 2 | EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 | | ENSG00000206403 | O958701, 2 | EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 | | BAT5 | O958701, 2 | EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 | | BAT5 | O958701, 2 | EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 | About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for IFITM1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFITM1
|
Transcripts for IFITM1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003641
Sigma-Aldrich siRNA and siRNA Panels for IFITM1  Sigma-Aldrich shRNA for IFITM1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003641 REFSEQ mRNAs for IFITM1 gene: NM_003641.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003641               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003641                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003641                                  untagged cDNA clone in CMV expression vector: NM_003641  Additional cDNA sequence: AK290480.1 BC000897.1 BT007173.1 J04164.1 X84958.1 15 DOTS entries: DT.318215 DT.86855828 DT.92329365 DT.120756284 DT.95164236 DT.97863531 DT.91657632 DT.95164221 DT.100687225 DT.120756268 DT.91775643 DT.91806015 DT.95164237 DT.95164274 DT.91775641 24/991 AceView cDNA sequences (see all 991
):BG504643 BQ447972 BG502912 BQ637680 CD622669 BG612707 CD622664 BG504275 R53017 BM767351 AA299136 BU630740 BQ269618 AA702139 AA602763 R52262 BM670465 AA379179 AI754120 CR604902 BG218401 AA886388 BM672752 CA420737
highest scoring ESTs for IFITM1:J04164 AA036757 AA055586 AA057115 AA058323 AA058453 AA149002 AA169338 AA226502 AA293127 Unigene Cluster for IFITM1: Interferon induced transmembrane protein 1 (9-27) Hs.458414 [show with all ESTs]Unigene Representative Sequence: BF210063
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for IFITM1
3 Ensembl transcripts including schematic representations: ENST00000408968
ENST00000328221
ENST00000399815
|
Expression for IFITM1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFITM1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFITM1
1 / 2 / 3 6 probe-sets matching IFITM1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCATTGGAT
SOURCE GeneReport for Unigene cluster: Hs.458414
Expression variation in blood from EXPOLDB for IFITM1 |
Orthologs for IFITM1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFITM1 gene from 3 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
LOC4759351 |
-- |
similar to Interferon-induced transmembrane protein more |
74.1(n) 62.81(a) |
475935 XM_533144.2 XP_533144.2 |
rat (Rattus norvegicus) |
Ifitm11 |
-- |
interferon induced transmembrane protein 1 |
74.76(n) 66.02(a) |
293618 XM_215117.4 XP_215117.2 |
mouse (Mus musculus) |
Ifitm15 |
7 |
interferon induced transmembrane protein 1 |
-- |
CR519995 |
About this table Species with no ortholog for IFITM1
ENSEMBL Gene Tree for IFITM1 | Paralogs for IFITM1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFITM1 gene
- ENSG000001880822 IFITM32 IFITM52 IFITM22 IFITM8P2
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for IFITM1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFITM1 (up to first 250kb)
|
Disorders & Mutations for IFITM1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604456
1 Novoseek disease relationship for IFITM1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
1 |
15506241 (1) |
About this table
|
Medical News for IFITM1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFITM1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for IFITM1 gene (see all 24
):- Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. (PubMed id 7559564)1, 2, 3, 4 Deblandre G.A.... Wathelet M.G. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A single DNA response element can confer inducibility by both alpha- and gamma-interferons. (PubMed id 2492664)3, 4 Reid L.E.... Kerr I.M. (1989)
- Expression of IFITM1 in chronic myeloid leukemia patients. (PubMed id 15661263)1, 3 Akyerli C.B....Ozcelik T. (2005)
- Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays. (PubMed id 12926988)1, 3 Kita K....Suzuki N. (2003)
- TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. (PubMed id 2398277)1, 3 Takahashi S....Levy R. (1990)
- Selection of a novel drug-response predictor in esophageal cancer: a novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response. (PubMed id 18202764)1, 3 Fumoto S....Nishiyama M. (2008)
- IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression. (PubMed id 18829488)3 Hatano H....Takata T. (2008)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)4 Taylor T.D....Sakaki Y. (2006)
- The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells. (PubMed id 15808405)3 Yang Y....Choi I. (2005)
|
Search for IFITM1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFITM1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFITM1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFITM1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFITM1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFITM1:

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Incremental update: 13 Oct 2009
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