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IFITM1 Gene

protein-coding   GIFtS: 63
GCID: GC11P000313

Interferon Induced Transmembrane Protein 1

(Previous name: interferon induced transmembrane protein 1 (9-27))
(Previous symbol: IFI17)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Induced Transmembrane Protein 11 2     CD2252 3
IFI171 2 3 5     DSPA2a2 3
Interferon-Induced Transmembrane Protein 11 2     LEU132 5
Dispanin Subfamily A Member 2a2 3     Interferon Induced Transmembrane Protein 1 (9-27)1
Interferon-Induced Protein 172 3     9-272
Interferon-Inducible Protein 9-272 3     CD225 Antigen3
Leu-13 Antigen2 3     

External Ids:    HGNC: 54121   Entrez Gene: 85192   Ensembl: ENSG000001858857   OMIM: 6044565   UniProtKB: P131643   

Export aliases for IFITM1 gene to outside databases

Previous GC identifers: GC11U990162 GC11M000883 GC11P000304 GC11P000303 GC11P000133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFITM1 Gene:
IFITM1 (interferon induced transmembrane protein 1) is a protein-coding gene. Diseases associated with IFITM1 include west nile virus, and peutz-jeghers syndrome. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is IFITM3.

UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV
GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and
control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by
inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a
positive regulator of osteoblast differentiation

Gene Wiki entry for IFITM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFITM1 gene promoter:
         GR   STAT1   Pax-5   STAT3   ZID   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM1 promoter sequence
   Search Chromatin IP Primers for IFITM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFITM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000313:  view genomic region     (about GC identifiers)

Start:
313,506 bp from pter      End:
315,272 bp from pter
Size:
1,767 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 1  
Size: 125 amino acids; 13964 Da
Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation.
Interacts with CD81
Secondary accessions: Q15322 Q53XZ0

Explore the universe of human proteins at neXtProt for IFITM1: NX_P13164

Explore proteomics data for IFITM1 at MOPED

Post-translational modifications: 

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    against influenza virus (By similarity)1
  • Ubiquitination2 at Lys67
  • Modification sites at PhosphoSitePlus

  • See IFITM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003632.3  
    ENSEMBL proteins: 
     ENSP00000437057   ENSP00000330825   ENSP00000386187  
    Reactome Protein details: P13164

    IFITM1 Human Recombinant Protein Products:

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    OriGene Purified Protein for IFITM1
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    Novus Biologicals IFITM1 Proteins
    Novus Biologicals IFITM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFITM1

    IFITM1 Antibody Products:

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    Abcam antibodies for IFITM1
    Cloud-Clone Corp. Antibodies for IFITM1
    ThermoFisher Antibodies for IFITM1
    LSBio Antibodies in human, mouse, rat for IFITM1

    IFITM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IFITM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFITM1
    Cloud-Clone Corp. CLIAs for IFITM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR007593 CD225/Dispanin_fam

    Graphical View of Domain Structure for InterPro Entry P13164

    ProtoNet protein and cluster: P13164

    1 Blocks protein domain: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Similarity: Belongs to the CD225/Dispanin family


    IFITM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFM1_HUMAN, P13164
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active
    against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola
    virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and
    hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV
    GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and
    control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by
    inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a
    positive regulator of osteoblast differentiation
    Induction: By IFN-alpha and IFNG/IFN-gamma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS7559564
    GO:0005515protein binding IPI2398277
         
    IFITM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFITM1:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ifitm1):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  reproductive system  skeleton 

    IFITM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFITM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFITM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFITM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFITM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFITM1:
    hsa-mir-146a-5p (MIRT021233), hsa-mir-130a-3p (MIRT006992), hsa-mir-335-5p (MIRT018732)

    Block miRNA regulation of human, mouse, rat IFITM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM1
    SwitchGear 3'UTR luciferase reporter plasmidIFITM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFITM1
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFITM1

    Clone
    Products:
         
    OriGene clones in human, mouse for IFITM1 (see all 7)
    OriGene ORF clones in mouse, rat for IFITM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM1 (NM_003641)
    Sino Biological Human cDNA Clone for IFITM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IFITM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFITM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFM1_HUMAN, P13164: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    IFITM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFITM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    3B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for IFITM1
        Interferon alpha/beta signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for IFITM1):
        B cell receptor signaling pathway


    IFITM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFITM1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFITM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFITM1 (P131642, 3 ENSP000003861874) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958702, 3, ENSP000003792824MINT-62697 MINT-62773 MINT-62599 I2D: score=5 STRING: ENSP00000379282
    ENSG00000236063O958702, 3, ENSP000004069654MINT-62697 MINT-62773 MINT-62599 I2D: score=5 STRING: ENSP00000406965
    ENSG00000206403O958702, 3MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    ENSG00000224552O958702, 3MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    ENSG00000230475O958702, 3MINT-62697 MINT-62773 MINT-62599 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0007166cell surface receptor signaling pathway TAS7559564
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0009607response to biotic stimulus ----
    GO:0009615response to virus IDA--

    IFITM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFITM1 (IFM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IFITM1 gene: 
    NM_003641.3  

    Unigene Cluster for IFITM1:

    Interferon induced transmembrane protein 1
    Hs.458414  [show with all ESTs]
    Unigene Representative Sequence: BF210063
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528780 ENST00000328221 ENST00000408968(uc001loy.4) ENST00000525554

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFITM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFITM1
    SwitchGear 3'UTR luciferase reporter plasmidIFITM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFITM1
    Predesigned siRNA for gene silencing in human, mouse, rat IFITM1
    Clone
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    OriGene clones in human, mouse for IFITM1 (see all 7)
    OriGene ORF clones in mouse, rat for IFITM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFITM1 (NM_003641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM1
    Primer
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    OriGene qPCR primer pairs and template standards for IFITM1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFITM1
      QuantiTect SYBR Green Assays in human, mouse, rat IFITM1
      QuantiFast Probe-based Assays in human, mouse, rat IFITM1

    Additional mRNA sequence: 

    AK290480.1 BC000897.1 BT007173.1 J04164.1 X84958.1 

    22 DOTS entries:

    DT.318215  DT.86855828  DT.92329365  DT.120756284  DT.95164236  DT.92409790  DT.97863531  DT.218787 
    DT.91728315  DT.91657632  DT.95164221  DT.91775643  DT.100687225  DT.120756268  DT.91775637  DT.91806015 
    DT.95164237  DT.95164274  DT.91775641  DT.91898740  DT.91904721  DT.92008914 

    Selected AceView cDNA sequences (see all 991):

    AA379179 BM672499 BM662200 BG612707 BE877564 BM670465 AA702139 AA293127 
    BG832111 BG504643 CD622664 BG218401 CR604902 R52262 BF437232 AA602763 
    BQ269618 AA302184 AI754120 BQ637680 BG502912 AA886388 R53017 BQ447972 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for IFITM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFITM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTGGAT
    IFITM1 Expression
    About this image


    IFITM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Eye (Sensory Organs)
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
    IFITM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFITM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458414

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Tissue specificity: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal
    cancer and ovarian cancer. Expressed in glioma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFITM1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFITM1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFITM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFITM1
    QuantiTect SYBR Green Assays in human, mouse, rat IFITM1
    QuantiFast Probe-based Assays in human, mouse, rat IFITM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFITM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFITM1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifitm15 interferon induced transmembrane protein 1   --   7 (86.20 cM) 140967221 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    1 → many
    5(1592827-1594156) ENSGALG00000026970
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    1(76990950-76998967)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-226m8.76
    si:dkey-226m8.7
    31(a)
    many ↔ many
    5(34876187-34876977) ENSDARG00000093303


    ENSEMBL Gene Tree for IFITM1 (if available)
    TreeFam Gene Tree for IFITM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFITM1 gene
    IFITM32  IFITM52  IFITM22  IFITM102  ENSG000002506442  
    3 SIMAP similar genes for IFITM1 using alignment to 1 protein entry:     IFM1_HUMAN:
    IFITM2    IFITM3    IFITM5

    IFITM1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IFITM1
    PGOHUM00000237578 PGOHUM00000249367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFITM1 (see all 95)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148086271,2
    C,F--250051(+) CAGGCG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1855641431,2
    --250147(+) GAATCA/CTGTCT 1 -- us2k10--------
    rs775378471,2
    C--250149(+) ATCCTG/ATCTCC 1 -- us2k13Minor allele frequency- A:0.32CSA WA EA 240
    rs594132521,2
    C,F--250193(+) TGCCCG/ATGATT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs777592501,2
    C,F--250262(+) GATGTG/ATGGCC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1912053671,2
    --250373(+) CAGACA/GTAGTT 1 -- us2k10--------
    rs592747101,2
    C,F--250462(+) GCGATC/TTGGGG 1 -- us2k12Minor allele frequency- T:0.33WA CSA 3
    rs1440132191,2
    --250665(+) GGCTCA/GTCCTG 1 -- us2k10--------
    rs801863321,2
    C,F--250673(+) CTGCTA/GCAATT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1464196021,2
    --250792(+) TTTAAA/GCTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFITM1 (313506 - 315272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IFITM1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527327CNV Loss19592680
    dgv917n71CNV Loss21882294
    dgv914n71CNV Loss21882294
    dgv915n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    nsv896447CNV Loss21882294
    nsv896463CNV Gain21882294
    dgv911n71CNV Gain21882294
    nsv499425OTHER Inversion21111241
    nsv513687OTHER Inversion21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFITM1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFITM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604456    OMIM disorders: --

    Selected diseases for IFITM1 (see all 23):    
    About MalaCards
    west nile virus    peutz-jeghers syndrome    rift valley fever    cervical squamous cell carcinoma
    hepatitis c virus    esophageal cancer    chronic myeloid leukemia    cervicitis
    influenza    hepatitis c    cervical cancer    tonsillitis
    esophagitis    myeloid leukemia    squamous cell carcinoma    hiv-1
    ovarian cancer    hepatitis    leukemia    cerebritis


    IFITM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for IFITM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15506241 (1)

    Genetic Association Database (GAD): IFITM1
    Human Genome Epidemiology (HuGE) Navigator: IFITM1 (4 documents)

    Export disorders for IFITM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFITM1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with IFITM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. (PubMed id 7559564)1, 2, 3, 9 Deblandre G.A.... Wathelet M.G. (J. Biol. Chem. 1995)
    2. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. (PubMed id 2398277)1, 2, 9 Takahashi S.... Levy R. (J. Immunol. 1990)
    3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)1, 2 Sallman Almen M.... Schioth H.B. (PLoS ONE 2012)
    4. IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. (PubMed id 22634173)1, 2 Kim B.S.... You H.K. (Bone 2012)
    5. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. (PubMed id 21253575)1, 2 Huang I.C....Farzan M. (PLoS Pathog. 2011)
    6. Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. (PubMed id 20838853)1, 2 Yu F....Lin M.C. (J. Neurooncol. 2011)
    7. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J.... Liang C. (J. Virol. 2011)
    8. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. (PubMed id 21976647)1, 2 Raychoudhuri A.... Ray R.B. (J. Virol. 2011)
    9. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8519 HGNC: 5412 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185885 euGenes: HUgn8519
    ECgene: IFITM1 Kegg: 8519 H-InvDB: IFITM1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IFITM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IFITM1 gene:
    Search GeneIP for patents involving IFITM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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