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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFITM1 Gene

protein-coding   GIFtS: 60
GCID: GC11P000313

interferon induced transmembrane protein 1

(Previous name: interferon induced transmembrane protein 1 (9-27) )
(Previous symbol: IFI17)
 Explore 19 diseases affiliated with
IFITM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IFITM1    

Aliases
for IFITM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interferon Induced Transmembrane Protein 11 2     Leu-13 Antigen2 3
IFI171 2 3 5     DSPA2a2 3
CD2251 2 3     LEU132 5
9-271 2     Interferon Induced Transmembrane Protein 1 (9-27)1
Dispanin Subfamily A Member 2a2 3     Interferon-Induced Transmembrane Protein 12
Interferon-Induced Protein 172 3     CD225 Antigen3
Interferon-Inducible Protein 9-272 3     

External Ids:    HGNC: 54121   Entrez Gene: 85192   Ensembl: ENSG000001858857   OMIM: 6044565   UniProtKB: P131643   

Export aliases for IFITM1 gene to outside databases

Previous GC identifers: GC11U990162 GC11M000883 GC11P000304 GC11P000303 GC11P000133


Summaries
for IFITM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against
multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV),
Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV).
Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and
SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration.
Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting
cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation

Gene Wiki entry for IFITM1


Genomic Views
for IFITM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFITM1 gene promoter:
         GR   STAT1   Pax-5   STAT3   ZID   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFITM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFITM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFITM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFITM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000313:  view genomic region     (about GC identifiers)

Start:
 313,506 bp from pter      End:
 315,272 bp from pter
Size:
 1,767 bases      Orientation:
 plus strand

Proteins
for IFITM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 1  
Size: 125 amino acids; 13964 Da
Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts
with CD81
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15322 Q53XZ0

Explore the universe of human proteins at neXtProt for IFITM1: NX_P13164

Post-translational modifications:

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity
    • against influenza virus (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13164

    • IFITM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003632.3  
    ENSEMBL proteins: 
     ENSP00000437057   ENSP00000330825   ENSP00000386187  
    Reactome Protein details: P13164
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: IFITM1
    OriGene Protein Over-expression Lysate: IFITM1
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    Novus Biologicals IFITM1 Proteins
    Novus Biologicals IFITM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IFITM1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    IFITM1 for ontologies           About GeneDecksing



    IFITM1 Antibody Products: 
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    Uscn Antibodies for IFITM1
    ThermoFisher Antibodies for IFITM1

    Assay Products for IFITM1: 
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    Uscn ELISAs and CLIAs for IFITM1

    Protein Domains /
    Families
    for IFITM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IFITM1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007593 Interferon-induced_TM_protein

    Graphical View of Domain Structure for InterPro Entry P13164

    ProtoNet protein and cluster: P13164

    1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Similarity: Belongs to the CD225/Dispanin family


    Function
    for IFITM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting
    endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against
    multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV),
    Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV).
    Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and
    SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration.
    Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting
    cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation
    Induction: By IFN-alpha and IFNG/IFN-gamma

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IFITM1
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    SwitchGear 3'UTR luciferase reporter plasmid: IFITM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFITM1 (see all 4)
    OriGene shRNA RFP: IFITM1
    OriGene siRNA: IFITM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IFITM1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFITM1 (see all 4)
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    Sino Biological Human cDNA Clone for IFITM1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFITM1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFITM1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS7559564
    GO:0005515protein binding IPI2398277


    IFITM1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IFITM1:
     Decreased Hepatitis C virus re 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ifitm1):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  reproductive system  skeleton 

    IFITM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IFITM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    5Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for IFITM1 (see all 7)
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Expression of IFN-induced genes
    Interferon Signaling


    1         Kegg Pathway  (Kegg details for IFITM1):
        B cell receptor signaling pathway


    IFITM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFITM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for IFITM1 (P131641, 2, 3 ENSP000003861874) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958701, 2, 3, ENSP000003792824EBI-348505,EBI-348517 MINT-62697 MINT-62773 MINT-62599 I2D: score=5 STRING: ENSP00000379282
    CR2P200233, ENSP000003560244I2D: score=3 STRING: ENSP00000356024
    CD81P600333, ENSP000002636454I2D: score=3 STRING: ENSP00000263645
    CD19P153913, ENSP000003134194I2D: score=1 STRING: ENSP00000313419
    ADARENSP000003574594STRING: ENSP00000357459
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0007166cell surface receptor signaling pathway TAS7559564
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0009615response to virus IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--


    IFITM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IFITM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFITM1
    Search CenterWatch for drugs/clinical trials and news about IFITM1 / IFM1 

    Transcripts
    for IFITM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IFITM1 gene: 
    NM_003641.3  

    Unigene Cluster for IFITM1:

    Interferon induced transmembrane protein 1
    Hs.458414  [show with all ESTs]
    Unigene Representative Sequence: BF210063
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528780 ENST00000328221 ENST00000408968(uc001loy.4) ENST00000525554


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFITM1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFITM1
    SwitchGear 3'UTR luciferase reporter plasmid: IFITM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFITM1 (see all 4)
    OriGene shRNA RFP: IFITM1
    OriGene siRNA: IFITM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFITM1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFITM1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IFITM1 (NM_003641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFITM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFITM1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFITM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFITM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFITM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM1

    Additional cDNA sequence: 

    AK290480.1 BC000897.1 BT007173.1 J04164.1 X84958.1 

    15 DOTS entries:

    DT.318215  DT.86855828  DT.92329365  DT.120756284  DT.95164236  DT.97863531  DT.91657632  DT.95164221 
    DT.100687225  DT.120756268  DT.91775643  DT.91806015  DT.95164237  DT.95164274  DT.91775641 

    24/991 AceView cDNA sequences (see all 991):

    BG218401 BG502912 BQ637680 BQ269618 CD622664 R52262 CR604902 AA602763 
    AI280158 BG194579 BF104076 AA299136 BM767351 AA886388 BQ447972 AA302184 
    R53017 BG504643 BF437232 BG832111 AA293127 AA702139 BE877564 BM670465 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for IFITM1

    Expression
    for IFITM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFITM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCATTGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IFITM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    MesodermMesodermMesoderm CellsEarly Embryo, Mesoderm
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See IFITM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFITM1

    SOURCE GeneReport for Unigene cluster: Hs.458414

    UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
    Tissue specificity: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal
    cancer and ovarian cancer. Expressed in glioma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including IFITM1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFITM1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFITM1

    Orthologs
    for IFITM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for IFITM1 (if available)
    TreeFam Gene Tree for IFITM1 (if available) 

    Paralogs
    for IFITM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFITM1 gene
    IFITM52  IFITM32  IFITM22  IFITM102  
    3 SIMAP similar genes for IFITM1 using alignment to 1 protein entry:     IFM1_HUMAN:
    IFITM2    IFITM3    IFITM5

    IFITM1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IFITM1
    PGOHUM00000237578 PGOHUM00000249367


    Genomic Variants
    for IFITM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 NCBI SNPs in IFITM1 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs759403071,2
    		C--134302(-) TGACCC/TCAGCA 1 -- int12Minor allele frequency- T:0.00NA 6

    HapMap Linkage Disequilibrium report for IFITM1 (313506 - 315272 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for IFITM1
         5 Inversions: 37119 37118 103322 29438 29435

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFITM1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFITM1

    Disorders / Diseases
    for IFITM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IFITM1 for disorders           About GeneDecksing

    OMIM gene information: 604456    OMIM disorders: --

    19 diseases for IFITM1:    About MalaCards
    peutz-jeghers syndrome    west nile virus    cervical squamous cell carcinoma    squamous cell carcinoma
    chronic myeloid leukemia    leukemia/lymphoma    myeloid leukemia    hepatitis c
    esophageal cancer    leukemia    esophagitis    cervicitis
    ovarian cancer    gastric cancer    influenza    breast cancer
    hepatitis    carcinoma    alcoholism

    1 Novoseek disease relationship for IFITM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15506241 (1)

    Human Genome Epidemiology (HuGE) Navigator: IFITM1 (4 documents)

    Export disorders for IFITM1 gene to outside databases

    Publications
    for IFITM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFITM1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with IFITM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. (PubMed id 7559564)1, 2, 3, 9 Deblandre G.A.... Wathelet M.G. (1995)
    2. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. (PubMed id 2398277)1, 2, 9 Takahashi S....Levy R. (1990)
    3. IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. (PubMed id 22634173)1, 2 Kim B.S.... You H.K. (2012)
    4. Distinct patterns of IFITM-mediated restriction of fi loviruses, SARS coronavirus, and influenza A virus. (PubMed id 21253575)1, 2 Huang I.C....Farzan M. (2011)
    5. Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. (PubMed id 20838853)1, 2 Yu F....Lin M.C. (2011)
    6. The IFITM proteins inhibit HIV-1 infection. (PubMed id 21177806)1, 2 Lu J....Liang C. (2011)
    7. ISG56 and IFITM1 proteins inhibit hepatitis C virus r eplication. (PubMed id 21976647)1, 2 Raychoudhuri A....Ray R.B. (2011)
    8. The IFITM proteins mediate cellular resistance to inf luenza A H1N1 virus, West Nile virus, and dengue virus. (PubMed id 20064371)1, 2 Brass A.L....Elledge S.J. (2009)
    9. Binding of IFITM1 enhances the inhibiting effect of c aveolin-1 on ERK activation. (PubMed id 19499152)1, 2 Xu Y....Hu G. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for IFITM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing IFITM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8519 HGNC: 5412 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185885 euGenes: HUgn8519
    ECgene: IFITM1 Kegg: 8519 H-InvDB: IFITM1

    Other Databases showing IFITM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IFITM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFITM1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IFITM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IFITM1 gene:
    Search GeneIP for patents involving IFITM1

    GeneCards and IP:
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