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IFITM1 Gene

protein-coding   GIFtS: 59

GC11P000303
interferon induced transmembrane protein 1 (9-27)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IFI17)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
9-27 1, 2
CD225 1, 2, 3
IFI17 2, 3, 5
LEU13 2, 5
Descriptions
CD225 antigen 3
Interferon-induced protein 17 2, 3
Interferon-inducible protein 9-27 3
Leu-13 antigen 3
interferon induced transmembrane protein 1 (9-27) 2
External Ids
HGNC: 54121
Entrez Gene: 85192
UniProtKB: P131643
Ensembl: ENSG000001858857
Search outside databases for aliases for IFITM1 gene

Previous GC identifers: GC11U990162 GC11M000883 GC11P000304

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Function: Implicated in the control of cell growth. Component of a multimeric complex involved in
the transduction of antiproliferative and homotypic adhesion signals

Gene Wiki entry for IFITM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFITM1 gene  

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IFITM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000303:     (about GC identifiers)

Start:
301,317 bp from pter
End:
305,272 bp from pter
Size:
3,956 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_035113.6  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164 (See protein sequence)
Recommended Name: Interferon-induced transmembrane protein 1  
Size: 125 amino acids; 13964 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q15322

REFSEQ proteins: NP_003632.3  

ENSEMBL proteins: 
ENSP00000386187 ENSP00000330825 ENSP00000382712 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (IFITM1)
Human Recombinant Proteins from Abnova (IFITM1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS7559564
GO:0016021 integral to membrane IEA--
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Antibodies for IFITM1: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for IFITM1
R&D Systems Antibodies for IFITM1
Antibodies from Abcam (IFITM1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (IFITM1)
Novus Biologicals Antibody for IFITM1

Assays for IFITM1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR007593 Interferon-induced_TM_protein


   GeneDecks  IFITM1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P13164

ProtoNet protein and cluster: P13164

1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein

UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Similarity: Belongs to the CD225 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFITM1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003641

              Applied Biosystems Silencer® siRNAs for IFITM1

              Sigma-Aldrich siRNA and siRNA Panels for IFITM1  
                     Sigma-Aldrich shRNA for IFITM1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IFITM1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003641
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003641
                                 untagged cDNA clone in CMV expression vector: NM_003641 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_003641

UniProtKB/Swiss-Prot: IFM1_HUMAN, P13164
Function: Implicated in the control of cell growth. Component of a multimeric complex involved in
the transduction of antiproliferative and homotypic adhesion signals
Induction: By alpha and gamma interferons

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005057 receptor signaling protein activity TAS7559564
GO:0005515 protein binding IPI14667819
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  IFITM1  (Your Favorite Gene powered by Ingenuity) 
 Interferon Signaling

   GeneDecks  IFITM1 for the pathways selected above  
About GeneDecksing

1 Kegg Pathway  (Kegg details for IFITM1):
 hsa04662 B cell receptor signaling pathway

   GeneDecks  IFITM1 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  IFITM1 


3 Interacting proteins for IFITM1 (P131641, 2) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000096467O958701, 2EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599
ENSG00000206403O958701, 2EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599
BAT5O958701, 2EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599
BAT5O958701, 2EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599 EBI-348505, EBI-348517 MINT-62697 MINT-62773 MINT-62599
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007166 cell surface receptor linked signal transduction TAS7559564
GO:0008285 negative regulation of cell proliferation TAS7559564
GO:0009607 response to biotic stimulus IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFITM1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFITM1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003641

              Sigma-Aldrich siRNA and siRNA Panels for IFITM1  
                     Sigma-Aldrich shRNA for IFITM1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_003641  

REFSEQ mRNAs for IFITM1 gene: 

NM_003641.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_003641  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003641
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003641
                                 untagged cDNA clone in CMV expression vector: NM_003641 

Additional cDNA sequence: 

AK290480.1 BC000897.1 BT007173.1 J04164.1 X84958.1 

15 DOTS entries:

DT.318215  DT.86855828  DT.92329365  DT.120756284  DT.95164236  DT.97863531  DT.91657632  DT.95164221 
DT.100687225  DT.120756268  DT.91775643  DT.91806015  DT.95164237  DT.95164274  DT.91775641 

24/991 AceView cDNA sequences (see all 991 ):

BG504643 BQ447972 BG502912 BQ637680 CD622669 BG612707 CD622664 BG504275 
R53017 BM767351 AA299136 BU630740 BQ269618 AA702139 AA602763 R52262 
BM670465 AA379179 AI754120 CR604902 BG218401 AA886388 BM672752 CA420737 

highest scoring ESTs for IFITM1:

J04164 AA036757 AA055586 AA057115 AA058323 AA058453 AA149002 AA169338 AA226502 AA293127 

Unigene Cluster for IFITM1:

Interferon induced transmembrane protein 1 (9-27)
Hs.458414  [show with all ESTs]
Unigene Representative Sequence: BF210063


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IFITM1

ExUns: 1a · 1b ^ 2a · 2b
SP1:                        
SP2:                        

About this scheme

ECgene alternative splicing isoforms for IFITM1

3 Ensembl transcripts including schematic representations:
ENST00000408968  ENST00000328221  ENST00000399815  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFITM1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFITM1

1 / 2 / 3

6 probe-sets matching IFITM1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

675_at2, 3 U95-A 1 1.00 1.00 0.97 0.89 J04164 1.00 0.75 0.88 1

676_g_at2, 3 U95-A 10 1.00 0.22 0.95 1.11 J04164 1.00 0.75 0.88 1

214022_s_at2, 3 U133-A 1 1.00 1.00 -- -- AA749101 0.80 0.88 0.84 1

201601_x_at2, 3 U133-A 6 1.00 0.82 -- -- NM_003641 0.60 0.83 0.73 1

214022_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

201601_x_at2 U133Plus2 6 1.00 0.82 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACCATTGGAT

SOURCE GeneReport for Unigene cluster: Hs.458414

Expression variation in blood from EXPOLDB for IFITM1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for IFITM1 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC4759351   -- similar to Interferon-induced transmembrane protein more 74.1(n)
62.81(a)
475935  XM_533144.2  XP_533144.2 
rat
(Rattus norvegicus)
Ifitm11   -- interferon induced transmembrane protein 1 74.76(n)
66.02(a)
293618  XM_215117.4  XP_215117.2 
mouse
(Mus musculus)
Ifitm15 7 interferon induced transmembrane protein 1   -- CR519995 
About this table        Species with no ortholog for IFITM1

ENSEMBL Gene Tree for IFITM1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for IFITM1 gene
ENSG000001880822  IFITM32  IFITM52  IFITM22  IFITM8P2  

Pseudogenes
2 related pseudogenes


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/18 NCBI SNPs in IFITM1 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 18)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs112460621,2
F,H303755(+) TGAACC/GGGGAC 1 -- ng511Minor allele frequency- G:0.28EU 120
--
rs96679901,2
C,H304207(+) TGGGGG/CCACCC 1 P/A mis1 ese34Minor allele frequency- C:0.00EU EA WA 414
--
rs11349141,2
C303054(-) CCAACC/TATTTC 1 -- ng511Minor allele frequency- T:0.00MN 184
--
rs115523621,2
H304303(+) ACACCC/GTCTTC 1 L/V mis1 trp34Minor allele frequency- G:0.00EU EA WA 372
rs11346691,2
H304161(+) CCCCAA/GAGCCA 1 -- ut51 ese34Minor allele frequency- G:0.00EU EA WA 418
--
rs124321,2
C,F304323(+) TGCTGC/TCTGGG 1 C/C syn11Minor allele frequency- T:0.05MN 184
rs31971371,2
F305009(+) TGATTC/TTGGGC 1 L/L syn1 ese31Minor allele frequency- T:0.01MN 184
rs115523611,2
--304247(+) GATCAA/GCATCC 1 N/S mis1 ese30--------
--
rs350794251,2
--303465(-) TTCCA-/GGGGCC 1 -- ng510--------
--
rs618762441,2
--302129(+) AAGGGA/CAGCTT 1 -- ng510--------
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HapMap Linkage Disequilibrium images for IFITM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604456

1 Novoseek disease relationship for IFITM1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0.00 1 15506241 (1)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/24 PubMed articles for IFITM1 gene (see all 24 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8519 HGNC: 5412 AceView: IFITM1andIFITM2 Ensembl:ENSG00000185885 euGenes: HUgn8519
ECgene: IFITM1 H-InvDB: IFITM1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFITM1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for IFITM1 Antibodies for IFITM1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFITM1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Search OriGene for IFITM1
 Search Tocris compounds for IFITM1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for IFITM1

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