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IFIT5 Gene

protein-coding   GIFtS: 50
GCID: GC10P091164

Interferon-Induced Protein With Tetratricopeptide Repeats...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 51 2     IFIT-52 3
Retinoic Acid- And Interferon-Inducible Protein (58kD)1 2     P582 3
Interferon-Induced 58 KDa Protein2 3     RI582 3
Retinoic Acid- And Interferon-Inducible 58 KDa Protein2 3     ISG583

External Ids:    HGNC: 133281   Entrez Gene: 241382   Ensembl: ENSG000001527787   UniProtKB: Q133253   

Export aliases for IFIT5 gene to outside databases

Previous GC identifers: GC10P090839 GC10P084808


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFIT5 Gene:
IFIT5 (interferon-induced protein with tetratricopeptide repeats 5) is a protein-coding gene. Diseases associated with IFIT5 include avian influenza, and influenza. GO annotations related to this gene include single-stranded RNA binding and RNA binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325
Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a
5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded
PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from
viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral
infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFIT5 gene promoter:
         Pax-3   NF-1   FOXC1   AML1a   STAT1beta   STAT1alpha   C/EBPalpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT5 promoter sequence
   Search Chromatin IP Primers for IFIT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091164:  view genomic region     (about GC identifiers)

Start:
91,174,325 bp from pter      End:
91,180,759 bp from pter
Size:
6,435 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 5  
Size: 482 amino acids; 55847 Da
Subunit: Monomer
6 PDB 3D structures from and Proteopedia for IFIT5:
3ZGQ (3D)        4HOQ (3D)        4HOR (3D)        4HOS (3D)        4HOT (3D)        4J0U (3D)    
Secondary accessions: B2R5X9 Q5T7I9 Q6IAX3

Explore the universe of human proteins at neXtProt for IFIT5: NX_Q13325

Explore proteomics data for IFIT5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFIT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036552.1  
    ENSEMBL proteins: 
     ENSP00000360860   ENSP00000414042  

    IFIT5 Human Recombinant Protein Products:

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    Novus Biologicals IFIT5 Protein
    Novus Biologicals IFIT5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IFIT5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IFIT5 Antibodies
    Abcam antibodies for IFIT5
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for IFIT5
    LSBio Antibodies in human, mouse, rat for IFIT5

    IFIT5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IFIT5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR024125 Interferon_induced_IFIT5
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13325

    ProtoNet protein and cluster: Q13325

    UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325
    Domain: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which
    scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420).
    Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating
    RNA entry (PubMed:23334420)
    Similarity: Belongs to the IFIT family
    Similarity: Contains 8 TPR repeats


    IFIT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT5_HUMAN, Q13325
    Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a
    5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded
    PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from
    viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral
    infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs
    Induction: By interferons (IFNs)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA--
    GO:0003723RNA binding IDA--
    GO:0003727single-stranded RNA binding IDA--
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    IFIT5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFIT5:
     Decreased cell number 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT5

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFIT5:
    hsa-mir-106b-5p (MIRT020470), hsa-let-7b-5p (MIRT001624), hsa-mir-146a-5p (MIRT021272)

    Block miRNA regulation of human, mouse, rat IFIT5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFIT5 (see all 12):
    hsa-miR-374b* hsa-miR-374b hsa-miR-548e hsa-miR-374a hsa-miR-513c hsa-miR-664 hsa-miR-548a-3p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidIFIT5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFIT5
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFIT5

    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT5 (NM_012420)
    Sino Biological Human cDNA Clone for IFIT5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFIT5
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFIT5_HUMAN, Q13325: Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles.
    Localizes to actin-rich protrusions from the apical cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton IDA--
    GO:0032587ruffle membrane IDA--
    GO:0045177apical part of cell IDA--

    IFIT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFIT5
    Interactions:

        Search GeneGlobe Interaction Network for IFIT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for IFIT5 (Q133252, 3 ENSP000003608604) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM66Q96BY92, 3, ENSP000002562554MINT-64350 I2D: score=4 STRING: ENSP00000256255
    USP33Q8TEY73, ENSP000003500094I2D: score=2 STRING: ENSP00000350009
    IFIT3O148793, ENSP000003608764I2D: score=1 STRING: ENSP00000360876
    A2MP010233I2D: score=1 
    CDC37Q165433I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--
    GO:0051607defense response to virus IMP--

    IFIT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFIT5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IFIT5 gene: 
    NM_012420.2  

    Unigene Cluster for IFIT5:

    Interferon-induced protein with tetratricopeptide repeats 5
    Hs.252839  [show with all ESTs]
    Unigene Representative Sequence: NM_012420
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371795(uc010qng.1 uc010qnh.2) ENST00000416601
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFIT5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFIT5 (see all 12):
    hsa-miR-374b* hsa-miR-374b hsa-miR-548e hsa-miR-374a hsa-miR-513c hsa-miR-664 hsa-miR-548a-3p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidIFIT5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFIT5
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT5
    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT5 (NM_012420)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFIT5
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFIT5
      QuantiTect SYBR Green Assays in human, mouse, rat IFIT5
      QuantiFast Probe-based Assays in human, mouse, rat IFIT5

    Additional mRNA sequence: 

    AK293346.1 AK312358.1 BC025786.1 CR457031.1 U34605.1 

    10 DOTS entries:

    DT.99928080  DT.115118  DT.100779198  DT.100695269  DT.121275488  DT.97817164  DT.75132262  DT.121275368 
    DT.121275560  DT.101982854 

    Selected AceView cDNA sequences (see all 127):

    H97226 F08681 AI834343 Z40106 AA953281 CB158576 AI139344 CB250501 
    AL534150 AI475939 BI913124 AL045202 BC025786 CR624828 N56801 AI127553 
    BX953537 CB135441 AA376865 AA643931 BF511481 BV194720 C02607 BF726007 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFIT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFIT5 Expression
    About this image

    IFIT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFIT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252839
        Custom PCR Arrays for IFIT5
    Primer
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    OriGene qPCR primer pairs and template standards for IFIT5
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    QuantiFast Probe-based Assays in human, mouse, rat IFIT5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia IFIT51 interferon-induced protein with tetratricopeptide repeats more 92.32(n)
    92.74(a)
      486788  XM_005637512.1  XP_005637569.1 
    chicken
    (Gallus gallus)
    Aves IFIT51 interferon-induced protein with tetratricopeptide repeats more 59.31(n)
    49.37(a)
      423790  XM_421662.4  XP_421662.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    GL343442.1(893678-894883)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004869541 interferon-induced protein with tetratricopeptide repeats more 54.36(n)
    43.63(a)
      100486954  XM_002937191.2  XP_002937237.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26g8.111 si:dkey-26g8.11 49.64(n)
    37.07(a)
      567441  XM_690737.3  XP_695829.2 


    ENSEMBL Gene Tree for IFIT5 (if available)
    TreeFam Gene Tree for IFIT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFIT5 gene
    IFIT12  IFIT1B2  IFIT32  IFIT22  
    4 SIMAP similar genes for IFIT5 using alignment to 2 protein entries:     IFIT5_HUMAN (see all proteins):
    IFIT1    IFIT1B    IFIT3    IFIT2

    IFIT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFIT5 (see all 250)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3044401,2
    C,F,A,H--91172336(-) agattT/Cgttgc 1 -- us2k15Minor allele frequency- C:0.23NS EA NA 414
    rs1903654821,2
    --91172350(+) TGCTGC/TTCACT 1 -- us2k10--------
    rs1441766261,2
    C--91172371(+) ACACTA/GCCTTT 1 -- us2k10--------
    rs1811688541,2
    --91172373(+) ACTGCC/TTTTAT 1 -- us2k10--------
    rs21026981,2
    C,F,A--91172431(-) gtggtT/Ctcact 1 -- us2k16Minor allele frequency- C:0.05NA WA CSA EA 248
    rs1860094361,2
    --91172433(+) TGAAAC/GCACGA 1 -- us2k10--------
    rs1465529421,2
    --91172445(+) CCCACC/TGGGAG 1 -- us2k10--------
    rs1148502841,2
    F--91172469(+) CGGACG/ACGCCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1908634671,2
    --91172504(+) GTGAAA/GGTCTG 1 -- us2k10--------
    rs792428901,2
    C--91172557(+) AGGAA-/GAAACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT5 (91174325 - 91180759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819719CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFIT5
    DNA2.0 Custom Variant and Variant Library Synthesis for IFIT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for IFIT5:    About MalaCards
    avian influenza    influenza    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for IFIT5:
    Avian influenza

    IFIT5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): IFIT5
    Human Genome Epidemiology (HuGE) Navigator: IFIT5 (1 document)

    Export disorders for IFIT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFIT5 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with IFIT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel interferon-inducible gene expressed during myeloid differentiation. (PubMed id 9398535)1, 2, 3, 9 Niikura T.... Weil S.C. (Blood Cells Mol. Dis. 1997)
    2. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PubMed id 23334420)1, 2 Abbas Y.M.... Nagar B. (Nature 2013)
    3. tRNA binding, structure, and localization of the human interferon- induced protein IFIT5. (PubMed id 23317505)1, 2 Katibah G.E.... Collins K. (Mol. Cell 2013)
    4. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Crystal structure and nucleotide selectivity of human IFIT5/ISG58. (PubMed id 23774268)1 Feng F....Liang H. (Cell Res. 2013)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24138 HGNC: 13328 AceView: IFIT5 Ensembl:ENSG00000152778 euGenes: HUgn24138
    ECgene: IFIT5 H-InvDB: IFIT5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFIT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFIT5 gene:
    Search GeneIP for patents involving IFIT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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