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IFIT5 Gene

protein-coding GIFtS: 47

GC10P091164

interferon-induced protein with tetratricopeptide repeats 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ53857 ^²
FLJ92678 ^²
IFIT-5 ^³
OTTHUMP00000020063 ^²
RI58 ^¹, ², ³

Descriptions
Retinoic acid- and interferon-inducible 58 kDa protein ^³
interferon-induced protein with tetratricopeptide repeats 5 ^²
retinoic acid- and interferon-inducible protein (58kD) ^²

External Ids
HGNC: 13328¹
Entrez Gene: 24138²
UniProtKB: Q13325³
Ensembl: ENSG00000152778⁷

Search outside databases for aliases for IFIT5 gene

Previous GC identifer: GC10P090839

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFIT5 gene

Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23.3

IFIT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P091164: (about GC identifiers)

Start:	91,164,419 bp from pter
End:	91,170,733 bp from pter
Size:	6,315 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325 (See protein sequence)

Recommended Name: Interferon-induced protein with tetratricopeptide repeats 5

Size: 482 amino acids; 55847 Da

Secondary accessions: Q5T7I9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036552.1

ENSEMBL proteins:

ENSP00000360860

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFIT5)
	Human Recombinant Proteins from Abnova (IFIT5)

OriGene Purified Recombinant Human Protein: IFIT5

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

About this table

Antibodies for IFIT5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFIT5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFIT5)
	Novus Biologicals Antibody for IFIT5

Assays for IFIT5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13325

ProtoNet protein and cluster: Q13325

UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325

Similarity: Belongs to the IFIT family

Similarity: Contains 8 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFIT5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012420

Applied Biosystems Silencer® siRNAs for IFIT5

Sigma-Aldrich siRNA for IFIT5

Sigma-Aldrich shRNA for IFIT5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFIT5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012420
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012420
untagged cDNA clone in CMV expression vector: NM_012420

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012420

UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325

Induction: By interferons

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for IFIT5 (Q13325²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
TMEM66 Q96BY9² MINT-64350
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFIT5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFIT5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012420

Sigma-Aldrich siRNA for IFIT5

Sigma-Aldrich shRNA for IFIT5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012420

REFSEQ mRNAs for IFIT5 gene:

NM_012420.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012420

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012420
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012420
                                 untagged cDNA clone in CMV expression vector: NM_012420

Additional cDNA sequence:

AK293346.1 AK312358.1 BC025786.1 CR457031.1 CR624828.1 U34605.1

10 DOTS entries:

DT.99928080 DT.115118 DT.100779198 DT.100695269 DT.121275488 DT.75132262 DT.97817164 DT.121275368

DT.121275560 DT.101982854

24/127 AceView cDNA sequences (see all 127 ):

AL534150 AI139344 Z40106 AI475939 AI834343 CB250501 BC025786 H97226

CB158576 AI127553 AA953281 AL045202 CR624828 BI913124 F08681 N56801

BF726007 AW157786 CR457031 AI244971 BG204083 AI087225 AA643931 AI819883

highest scoring ESTs for IFIT5:

U34605 AA234514 AA296906 AA298466 AA329567 AA359837 AA376865 AA634930 AA635726 AA643931

Unigene Cluster for IFIT5:

Interferon-induced protein with tetratricopeptide repeats 5

Hs.252839 [show with all ESTs]

Unigene Representative Sequence: NM_012420

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000371795

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFIT5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFIT5

¹ / ² / ³

5 probe-sets matching IFIT5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1046_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U34605	1.00	1.00	1.00	1
203595_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N47725	0.60	1.00	0.82	1
203596_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012420	0.60	1.00	0.82	1
203595_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203596_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IFIT5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.252839
Expression variation in blood from EXPOLDB for IFIT5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFIT5 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFIT5¹	--	interferon-induced protein with tetratricopeptide repeats more	92.5(n) 92.92(a)	486788 XM_543917.2 XP_543917.2
chimpanzee (Pan troglodytes)	IFIT5¹	--	interferon-induced protein with tetratricopeptide repeats more	99.51(n) 99.58(a)	466152 XM_521554.2 XP_521554.2
cow (Bos taurus)	IFIT5¹	--	interferon-induced protein with tetratricopeptide repeats more	90.87(n) 92.53(a)	515091 NM_001075698.1 NP_001069166.1
chicken (Gallus gallus)	IFIT5¹	--	interferon-induced protein with tetratricopeptide repeats more	59.52(n) 49.37(a)	423790 XM_421662.2 XP_421662.2
zebrafish (Danio rerio)	LOC567441¹	--	similar to interferon-inducible protein IFI58	49.71(n) 37.07(a)	567441 XM_690737.2 XP_695829.2

About this table Species with no ortholog for IFIT5

ENSEMBL Gene Tree for IFIT5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFIT5 gene

IFIT1² IFIT3² IFIT1L² IFIT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/70 NCBI SNPs in IFIT5 are shown (see all 70 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 40)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs304447^1,2	A,C,F,H,O	91168784(+)	`GATAGT/CTAAGC`	1	--	ut3¹		9		MN EU EA WA	1020
	rs303172^1,2	A,C,F,H	91169809(+)	`AGTCCC/TCTCAC`	1	--	ut3¹ ese³		12		EA NA EU WA	1034
	rs7095488^1,2	A,C,F,H	91164155(+)	`AGGCAG/CATAAA`	1	--	ng5¹		8		EU EA WA	836
	rs184236^1,2	A,C,F,H	91169275(-)	`TAATCT/GATGGG`	1	--	ut3¹		5		MN EU EA WA	602
--	rs11203115^1,2	C,F,H	91163377(+)	`TGCACG/ACATAT`	1	--	ng5¹		4		EU EA WA	372
	rs303171^1,2	C,F,H	91170793(+)	`AGTCTC/GTGAAA`	1	--	ng3¹		16		EU EA WA NA	1398
--	rs304438^1,2	A,C	91162910(-)	`atgaaA/Ctctaa`	1	--	ng5¹		0	--	--	--	--
	rs4934478^1,2	A,H	91164389(+)	`CACGCC/AGCGCG`	1	--	ut5¹ ese³		4		EU EA WA	414
--	rs304437^1,2	A,C	91163024(-)	`ATTAAA/GAACCT`	1	--	ng5¹		0	--	--	--	--
	rs7083630^1,2	A,C	91164128(+)	`CAGCAC/TGCGAA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IFIT5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for IFIT5 gene:

A novel interferon-inducible gene expressed during myeloid differentiation. (PubMed id 9398535)^{1, 2, 3, 4} Niikura T.... Weil S.C. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)⁴ Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. (PubMed id 17879257)¹ Perez D.S....Campain J.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 24138	HGNC: 13328	AceView: IFIT5	Ensembl:ENSG00000152778	euGenes: HUgn24138
ECgene: IFIT5	H-InvDB: IFIT5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFIT5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFIT5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFIT5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFIT5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFIT5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IFIT5)
	Antibodies (IFIT5)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IFIT5)
	Antibodies (IFIT5)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for IFIT5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IFIT5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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IFIT5 Gene at Home site.
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IFIT5 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for IFIT5

Summaries
for IFIT5

Genomic Location
for IFIT5

Proteins
for IFIT5

Protein Domains/
Families
for IFIT5

Gene Function
for IFIT5

Pathways & Interactions
for IFIT5

Drugs & Compounds
for IFIT5

Transcripts
for IFIT5

Expression
for IFIT5

Orthologs
for IFIT5

Paralogs
for IFIT5

SNPs/Variants
for IFIT5

Disorders & Mutations
for IFIT5

Medical News
for IFIT5

Publications
for IFIT5

Search for IFIT5

Genome Databases showing IFIT5

Other Databases showing IFIT5

Specialized Databases showing IFIT5

Licensable Technologies
for IFIT5

Services
for IFIT5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFIT5 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor IFIT5

Summariesfor IFIT5

Genomic Locationfor IFIT5

Proteinsfor IFIT5

Protein Domains/Familiesfor IFIT5

Gene Functionfor IFIT5

Pathways & Interactionsfor IFIT5

Drugs & Compoundsfor IFIT5

Transcriptsfor IFIT5

Expression for IFIT5

Orthologsfor IFIT5

Paralogsfor IFIT5

SNPs/Variantsfor IFIT5

Disorders & Mutationsfor IFIT5

Medical Newsfor IFIT5

Publicationsfor IFIT5

Search for IFIT5

Genome Databases showing IFIT5

Other Databases showing IFIT5

Specialized Databases showing IFIT5

Licensable Technologiesfor IFIT5

Servicesfor IFIT5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFIT5

Summaries
for IFIT5

Genomic Location
for IFIT5

Proteins
for IFIT5

Protein Domains/
Families
for IFIT5

Gene Function
for IFIT5

Pathways & Interactions
for IFIT5

Drugs & Compounds
for IFIT5

Transcripts
for IFIT5

Expression
for IFIT5

Orthologs
for IFIT5

Paralogs
for IFIT5

SNPs/Variants
for IFIT5

Disorders & Mutations
for IFIT5

Medical News
for IFIT5

Publications
for IFIT5

Licensable Technologies
for IFIT5

Services
for IFIT5