Aliases for IFIT5 Gene
External Ids for IFIT5 Gene
GeneCards Summary for IFIT5 Gene
IFIT5 (Interferon-Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. GO annotations related to this gene include RNA binding and single-stranded RNA binding. An important paralog of this gene is IFIT1.
UniProtKB/Swiss-Prot for IFIT5 Gene
Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.