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Aliases for IFIT5 Gene

Aliases for IFIT5 Gene

  • Interferon-Induced Protein With Tetratricopeptide Repeats 5 2 3
  • Retinoic Acid- And Interferon-Inducible Protein (58kD) 2 3
  • Retinoic Acid- And Interferon-Inducible 58 KDa Protein 3 4
  • Interferon-Induced 58 KDa Protein 3 4
  • IFIT-5 3 4
  • ISG58 3 4
  • RI58 3 4
  • P58 3 4

External Ids for IFIT5 Gene

Previous GeneCards Identifiers for IFIT5 Gene

  • GC10P090839
  • GC10P091164
  • GC10P084808

Summaries for IFIT5 Gene

GeneCards Summary for IFIT5 Gene

IFIT5 (Interferon-Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. GO annotations related to this gene include RNA binding and single-stranded RNA binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot for IFIT5 Gene

  • Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT5 Gene

Genomics for IFIT5 Gene

Regulatory Elements for IFIT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IFIT5 Gene

Start:
89,414,568 bp from pter
End:
89,421,002 bp from pter
Size:
6,435 bases
Orientation:
Plus strand

Genomic View for IFIT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFIT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT5 Gene

Proteins for IFIT5 Gene

  • Protein details for IFIT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13325-IFIT5_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 5
    Protein Accession:
    Q13325
    Secondary Accessions:
    • B2R5X9
    • B4DDV1
    • Q5T7I9
    • Q6IAX3

    Protein attributes for IFIT5 Gene

    Size:
    482 amino acids
    Molecular mass:
    55847 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for IFIT5 Gene

    Alternative splice isoforms for IFIT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFIT5 Gene

Proteomics data for IFIT5 Gene at MOPED

Post-translational modifications for IFIT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT5 Gene

Domains for IFIT5 Gene

Gene Families for IFIT5 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFIT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13325

UniProtKB/Swiss-Prot:

IFIT5_HUMAN :
  • Q13325
Domain:
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with IFIT5: view

Function for IFIT5 Gene

Molecular function for IFIT5 Gene

UniProtKB/Swiss-Prot Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
UniProtKB/Swiss-Prot Induction: By interferons (IFNs)

Gene Ontology (GO) - Molecular Function for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 23317505
GO:0003723 RNA binding IDA 21642987
GO:0003727 single-stranded RNA binding IDA 23334420
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with IFIT5: view

Phenotypes for IFIT5 Gene

GenomeRNAi human phenotypes for IFIT5:
genes like me logo Genes that share phenotypes with IFIT5: view

Animal Model Products

CRISPR Products

miRNA for IFIT5 Gene

miRTarBase miRNAs that target IFIT5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFIT5 Gene

Localization for IFIT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT5 Gene

Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT5 Gene COMPARTMENTS Subcellular localization image for IFIT5 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IDA 23317505
GO:0032587 ruffle membrane IDA 23317505
GO:0045177 apical part of cell IDA 23317505
genes like me logo Genes that share ontologies with IFIT5: view

Pathways for IFIT5 Gene

SuperPathways for IFIT5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IMP 23334420
genes like me logo Genes that share ontologies with IFIT5: view

No data available for Pathways by source for IFIT5 Gene

Transcripts for IFIT5 Gene

mRNA/cDNA for IFIT5 Gene

(127) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFIT5 Gene

Interferon-induced protein with tetratricopeptide repeats 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT5 Gene

No ASD Table

Relevant External Links for IFIT5 Gene

GeneLoc Exon Structure for
IFIT5
ECgene alternative splicing isoforms for
IFIT5

Expression for IFIT5 Gene

mRNA expression in normal human tissues for IFIT5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT5 Gene

SOURCE GeneReport for Unigene cluster for IFIT5 Gene Hs.252839

genes like me logo Genes that share expressions with IFIT5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFIT5 Gene

Orthologs for IFIT5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT5 35
  • 99.38 (n)
  • 99.38 (a)
IFIT5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFIT5 35
  • 90.8 (n)
  • 92.53 (a)
IFIT5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIT5 35
  • 92.32 (n)
  • 92.74 (a)
IFIT5 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 48 (a)
OneToMany
IFIT5 35
  • 59.31 (n)
  • 49.37 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486954 35
  • 54.36 (n)
  • 43.63 (a)
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 36
  • 32 (a)
ManyToMany
ifit2 36
  • 22 (a)
ManyToMany
ifit5 36
  • 32 (a)
ManyToMany
si:ch211-240h7.2 36
  • 23 (a)
ManyToMany
si:dkey-116m16.3 36
  • 22 (a)
ManyToMany
si:dkey-26g8.10 36
  • 31 (a)
ManyToMany
si:dkey-26g8.11 35
  • 49.64 (n)
  • 37.07 (a)
si:dkey-26g8.11 36
  • 34 (a)
ManyToMany
zgc:123282 36
  • 30 (a)
ManyToMany
Species with no ortholog for IFIT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT5 Gene

ENSEMBL:
Gene Tree for IFIT5 (if available)
TreeFam:
Gene Tree for IFIT5 (if available)

Paralogs for IFIT5 Gene

Paralogs for IFIT5 Gene

Selected SIMAP similar genes for IFIT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFIT5: view

Variants for IFIT5 Gene

Sequence variations from dbSNP and Humsavar for IFIT5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs184236 -- 89,419,538(-) TAATC(G/T)ATGGG utr-variant-3-prime
rs303171 -- 89,421,056(+) AGTCT(C/G)TGAAA downstream-variant-500B
rs303172 -- 89,420,072(+) AGTCC(C/T)CTCAC utr-variant-3-prime
rs304434 -- 89,414,917(-) CGCGA(C/G)GGGCT intron-variant
rs304435 -- 89,413,783(-) ttttg(G/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFIT5 Gene

Variant ID Type Subtype PubMed ID
nsv819719 CNV Gain 19587683

Relevant External Links for IFIT5 Gene

HapMap Linkage Disequilibrium report
IFIT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT5 Gene

Disorders for IFIT5 Gene

(1) University of Copenhagen DISEASES for IFIT5 Gene

Relevant External Links for IFIT5

Genetic Association Database (GAD)
IFIT5
Human Genome Epidemiology (HuGE) Navigator
IFIT5
genes like me logo Genes that share disorders with IFIT5: view

No data available for UniProtKB/Swiss-Prot for IFIT5 Gene

Publications for IFIT5 Gene

  1. A novel interferon-inducible gene expressed during myeloid differentiation. (PMID: 9398535) Niikura T. … Weil S.C. (Blood Cells Mol. Dis. 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. tRNA binding, structure, and localization of the human interferon- induced protein IFIT5. (PMID: 23317505) Katibah G.E. … Collins K. (Mol. Cell 2013) 3 4
  5. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PMID: 23334420) Abbas Y.M. … Nagar B. (Nature 2013) 3 4

Products for IFIT5 Gene

Sources for IFIT5 Gene

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