IFIT5 Gene
protein-coding GIFtS: 49
GCID: GC10P091164
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interferon-induced protein with tetratricopeptide repeats...
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Aliases
for IFIT5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon-Induced Protein With Tetratricopeptide Repeats 51 2 | | IFIT-52 3 | | RI581 2 3 | | P582 3 | | Interferon-Induced 58 KDa Protein2 3 | | Retinoic Acid- And Interferon-Inducible Protein (58kD)2 | | Retinoic Acid- And Interferon-Inducible 58 KDa Protein2 3 | | ISG583 |
Export aliases for IFIT5 gene to outside databasesPrevious GC identifers: GC10P090839 GC10P084808 |
Summaries
for IFIT5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphategroup (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing amolecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly bindsPPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs
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Genomic Views
for IFIT5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFIT5 gene promoter:
Pax-3 NF-1 FOXC1 AML1a STAT1beta STAT1alpha C/EBPalpha ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFIT5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23.31IFIT5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P091164: view genomic region
(about GC identifiers)
Start:
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91,174,325 bp from pter |
End:
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91,180,759 bp from pter |
Size:
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6,435 bases |
Orientation:
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plus strand |
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Proteins
for IFIT5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325 (See
protein sequence)Recommended Name: Interferon-induced protein with tetratricopeptide repeats 5 Size: 482 amino acids; 55847 Da
Subunit: Monomer
Subcellular location: Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles.Localizes to actin-rich protrusions from the apical cell surface
6 PDB 3D structures from  and Proteopedia  for IFIT5:3ZGQ (3D)
4HOQ (3D)
4HOR (3D)
4HOS (3D)
4HOT (3D)
4J0U (3D)
Secondary accessions: B2R5X9 Q5T7I9 Q6IAX3Explore the universe of human proteins at neXtProt for IFIT5: NX_Q13325
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13325
IFIT5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036552.1
ENSEMBL proteins: ENSP00000360860 ENSP00000414042
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
IFIT5 for ontologies About GeneDecksing
IFIT5 Antibody Products:
Assay Products for IFIT5: |
Protein
Domains /
Families
for IFIT5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFIT5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13325ProtoNet protein and cluster: Q13325 UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325Domain: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffoldsunique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420). Undergoes aconformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry(PubMed:23334420)Similarity: Belongs to the IFIT familySimilarity: Contains 8 TPR repeats |
Function
for IFIT5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFIT5_HUMAN, Q13325Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphategroup (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing amolecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly bindsPPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAsInduction: By interferons (IFNs)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFIT5 (NM_012420) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFIT5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT5 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IFIT5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IFIT5:
|
Pathways & Interactions
for IFIT5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFIT5
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/12 Interacting proteins for IFIT5 (Q133252, 3 ENSP000003608604) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
-- | -- | | GO:0045087 | innate immune response |
IEA | -- | | GO:0051607 | defense response to virus |
IMP | -- |
IFIT5 for ontologies About GeneDecksing
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Drugs & Compounds
for IFIT5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFIT5
Search CenterWatch for drugs/clinical trials and news about IFIT5
|
Transcripts
for IFIT5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFIT5 gene: NM_012420.2 Unigene Cluster for IFIT5: Interferon-induced protein with tetratricopeptide repeats 5 Hs.252839 [show with all ESTs]Unigene Representative Sequence: NM_0124202 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371795(uc010qng.1 uc010qnh.2) ENST00000416601
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFIT5 (NM_012420) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFIT5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT5 |
Additional cDNA sequence: AK293346.1 AK312358.1 BC025786.1 CR457031.1 U34605.1 10 DOTS entries: DT.99928080 DT.115118 DT.100779198 DT.100695269 DT.121275488 DT.97817164 DT.75132262 DT.121275368 DT.121275560 DT.101982854 24/127 AceView cDNA sequences (see all 127): AI139344 AL534150 AI834343 CR624828 Z40106 BC025786 AI127553 AL045202 CB250501 H97226 CB158576 BI913124 AA953281 F08681 N56801 AI475939 U34605 BF511481 BG204083 AI929183 AA298466 BI834654 AI795861 BF726007
GeneLoc Exon Structure
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Expression
for IFIT5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFIT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IFIT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFIT5
SOURCE GeneReport for Unigene cluster: Hs.252839
SABiosciences Custom PCR Arrays for IFIT5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFIT5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFIT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT5 |
Orthologs
for IFIT5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFIT5 gene from 3/8 species (see all 8) About this table
Species with no ortholog for IFIT5
ENSEMBL Gene Tree for IFIT5 (if available)
TreeFam Gene Tree for IFIT5 (if available) |
Paralogs
for IFIT5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFIT5 gene
- IFIT12 IFIT1B2 IFIT32 IFIT22
4 SIMAP similar genes for IFIT5 using alignment to 2 protein entries: IFIT5_HUMAN (see all proteins):IFIT1 IFIT1B IFIT3 IFIT2
IFIT5 for paralogs About GeneDecksing
|
Genomic Variants
for IFIT5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFIT5 (91174325 - 91180759 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFIT5
1 CNV: 58479 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFIT5 |
|
Disorders
/ Diseases
for IFIT5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFIT5 for disorders About GeneDecksing
3  diseases for IFIT5: About MalaCardsavian influenza alzheimer's disease influenza
1 disease from the University of Copenhagen DISEASES database for IFIT5:Avian influenza Human Genome Epidemiology (HuGE) Navigator: IFIT5 (1 document)
Export disorders for IFIT5 gene to outside databases
|
Publications
for IFIT5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFIT5 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with IFIT5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel interferon-inducible gene expressed during myeloid differentiation. (PubMed id 9398535)1, 2, 3, 9 Niikura T.... Weil S.C. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PubMed id 23334420)2 Abbas Y.M.... Nagar B. (2013)
- tRNA binding, structure, and localization of the human interferon- induced protein IFIT5. (PubMed id 23317505)2 Katibah G.E.... Collins K. (2013)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- The ISG56/IFIT1 gene family. (PubMed id 20950130)2 Fensterl V. and Sen G.C. (2011)
- IFIT1 is an antiviral protein that recognizes 5'-trip hosphate RNA. (PubMed id 21642987)2 Pichlmair A....Superti-Furga G. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
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External Searches for IFIT5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFIT5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFIT5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFIT5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFIT5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IFIT5 gene:
Search GeneIP for patents involving IFIT5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFIT5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFIT5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFIT5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFIT5 | | | OriGene Protein Over-expression Lysate for IFIT5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFIT5 | | OriGene 3'-UTR Clone for IFIT5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IFIT5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFIT5 | | OriGene Custom Protein Services for IFIT5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFIT5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFIT5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFIT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT5 |
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| | | | Search Tocris compounds for IFIT5 |
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 | | | IFIT5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT5 |
|  |  |  | | | | Search ThermoFisher Antibodies for IFIT5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT5 |
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