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Aliases for IFIT5 Gene

Aliases for IFIT5 Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 5 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 5 2 3
  • Retinoic Acid- And Interferon-Inducible Protein (58kD) 2 3
  • Retinoic Acid- And Interferon-Inducible 58 KDa Protein 3 4
  • Interferon-Induced 58 KDa Protein 3 4
  • IFIT-5 3 4
  • ISG58 3 4
  • RI58 3 4
  • P58 3 4

External Ids for IFIT5 Gene

Previous GeneCards Identifiers for IFIT5 Gene

  • GC10P090839
  • GC10P091164
  • GC10P084808

Summaries for IFIT5 Gene

GeneCards Summary for IFIT5 Gene

IFIT5 (Interferon Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is IFIT1B.

UniProtKB/Swiss-Prot for IFIT5 Gene

  • Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).

Additional gene information for IFIT5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT5 Gene

Genomics for IFIT5 Gene

GeneHancer (GH) Regulatory Elements for IFIT5 Gene

Promoters and enhancers for IFIT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I089413 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 585.7 +0.3 261 2.9 PKNOX1 FOXA2 SIN3A DMAP1 ZNF2 IRF4 ZNF48 YY1 GLIS2 KLF7 IFIT5 GC10P089413 LIPA KIF20B IFIT1B SLC16A12-AS1
GH10I089391 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 34.6 -21.5 -21521 2.8 ARID4B SIN3A ZNF76 IRF4 BRCA1 RAD21 ETS1 RFX5 SCRT2 ZNF207 IFIT1 IFIT5 ENSG00000232110 SLC16A12-AS1 GC10P089413 LIPA
GH10I089326 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 26.3 -86.6 -86555 3.7 ATF1 ZNF133 ARID4B YY1 GLIS2 ATF7 RXRA NCOA1 REST ZNF518A IFIT3 IFIT5 IFIT2 ENSG00000232110 IFIT1 LOC101926887 GC10M089235 LIPA
GH10I089330 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 23.2 -81.9 -81851 5.2 FOXA2 SMAD1 MLX ARID4B YBX1 IRF4 YY1 ZNF207 ATF7 RUNX3 IFIT3 IFIT5 IFIT2 IFIT1B ENSG00000232110 IFIT1 LOC101926887 GC10M089235 LIPA
GH10I089295 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 36.2 -118.0 -118042 3 MAX CEBPB CEBPG HNF4A PRDM1 IFIT3 IFIT2 IFIT5 IFIT1 IFIT1B FAS ENSG00000232110 LOC105378419 GC10M089235 LIPA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFIT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFIT5 gene promoter:

Genomic Locations for IFIT5 Gene

Genomic Locations for IFIT5 Gene
chr10:89,414,568-89,421,002
(GRCh38/hg38)
Size:
6,435 bases
Orientation:
Plus strand
chr10:91,174,325-91,180,759
(GRCh37/hg19)

Genomic View for IFIT5 Gene

Genes around IFIT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT5 Gene

Proteins for IFIT5 Gene

  • Protein details for IFIT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13325-IFIT5_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 5
    Protein Accession:
    Q13325
    Secondary Accessions:
    • B2R5X9
    • B4DDV1
    • Q5T7I9
    • Q6IAX3

    Protein attributes for IFIT5 Gene

    Size:
    482 amino acids
    Molecular mass:
    55847 Da
    Quaternary structure:
    • Monomer (PubMed:23317505, PubMed:23334420, PubMed:23774268). Interacts with MAP3K7 and the components of the IKK core complex CHUK, IKBKB and IKBKG; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375).

    Three dimensional structures from OCA and Proteopedia for IFIT5 Gene

    Alternative splice isoforms for IFIT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFIT5 Gene

Post-translational modifications for IFIT5 Gene

No Post-translational modifications

Other Protein References for IFIT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT5 Gene

Domains & Families for IFIT5 Gene

Gene Families for IFIT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13325

UniProtKB/Swiss-Prot:

IFIT5_HUMAN :
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).
  • Belongs to the IFIT family.
Domain:
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).
Family:
  • Belongs to the IFIT family.
genes like me logo Genes that share domains with IFIT5: view

Function for IFIT5 Gene

Molecular function for IFIT5 Gene

UniProtKB/Swiss-Prot Function:
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).
UniProtKB/Swiss-Prot Induction:
By interferons (IFNs).

Phenotypes From GWAS Catalog for IFIT5 Gene

Gene Ontology (GO) - Molecular Function for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 23317505
GO:0000339 RNA cap binding IDA 25092312
GO:0003690 double-stranded DNA binding IDA 23774268
GO:0003723 RNA binding IDA,IEA 21642987
GO:0003727 single-stranded RNA binding IDA 23334420
genes like me logo Genes that share ontologies with IFIT5: view
genes like me logo Genes that share phenotypes with IFIT5: view

miRNA for IFIT5 Gene

Clone Products

  • Addgene plasmids for IFIT5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFIT5 Gene

Localization for IFIT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT5 Gene

Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFIT5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA --
GO:0008385 colocalizes_with IkappaB kinase complex IMP 26334375
GO:0015629 actin cytoskeleton IDA 23317505
GO:0016020 membrane IEA --
GO:0032587 ruffle membrane IDA,IEA 23317505
genes like me logo Genes that share ontologies with IFIT5: view

Pathways & Interactions for IFIT5 Gene

SuperPathways for IFIT5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFIT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 26334375
GO:0045071 negative regulation of viral genome replication IDA 23774268
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IMP 23334420
genes like me logo Genes that share ontologies with IFIT5: view

No data available for Pathways by source and SIGNOR curated interactions for IFIT5 Gene

Drugs & Compounds for IFIT5 Gene

No Compound Related Data Available

Transcripts for IFIT5 Gene

mRNA/cDNA for IFIT5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFIT5 Gene

Interferon-induced protein with tetratricopeptide repeats 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for IFIT5

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT5 Gene

No ASD Table

Relevant External Links for IFIT5 Gene

GeneLoc Exon Structure for
IFIT5
ECgene alternative splicing isoforms for
IFIT5

Expression for IFIT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFIT5 Gene

Protein differential expression in normal tissues from HIPED for IFIT5 Gene

This gene is overexpressed in Lymph node (13.2) and Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFIT5 Gene



Protein tissue co-expression partners for IFIT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFIT5 Gene:

IFIT5

SOURCE GeneReport for Unigene cluster for IFIT5 Gene:

Hs.252839

Evidence on tissue expression from TISSUES for IFIT5 Gene

  • Nervous system(4.5)
  • Spleen(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with IFIT5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFIT5 Gene

Orthologs for IFIT5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT5 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia IFIT5 33 34
  • 92.32 (n)
cow
(Bos Taurus)
Mammalia IFIT5 33 34
  • 90.8 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IFIT5 33
  • 59.31 (n)
-- 34
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486954 33
  • 54.36 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26g8.11 33 34
  • 49.64 (n)
CR759879.1 34
  • 32 (a)
ManyToMany
ifit5 34
  • 32 (a)
ManyToMany
si:dkey-26g8.10 34
  • 31 (a)
ManyToMany
zgc:123282 34
  • 30 (a)
ManyToMany
si:ch211-240h7.2 34
  • 23 (a)
ManyToMany
ifit2 34
  • 22 (a)
ManyToMany
si:dkey-116m16.3 34
  • 22 (a)
ManyToMany
Species where no ortholog for IFIT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT5 Gene

ENSEMBL:
Gene Tree for IFIT5 (if available)
TreeFam:
Gene Tree for IFIT5 (if available)

Paralogs for IFIT5 Gene

Paralogs for IFIT5 Gene

(4) SIMAP similar genes for IFIT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFIT5: view

Variants for IFIT5 Gene

Sequence variations from dbSNP and Humsavar for IFIT5 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000206130 -- 89,420,849(+) T/A 3_prime_UTR_variant
rs1000297209 -- 89,413,743(+) A/C upstream_transcript_variant
rs1001609230 -- 89,414,512(+) C/G upstream_transcript_variant
rs1001903955 -- 89,420,581(+) C/T 3_prime_UTR_variant
rs1002168120 -- 89,420,926(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IFIT5 Gene

Variant ID Type Subtype PubMed ID
nsv819719 CNV gain 19587683

Variation tolerance for IFIT5 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFIT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFIT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT5 Gene

Disorders for IFIT5 Gene

Additional Disease Information for IFIT5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFIT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFIT5 Gene

Publications for IFIT5 Gene

  1. A novel interferon-inducible gene expressed during myeloid differentiation. (PMID: 9398535) Niikura T … Weil SC (Blood cells, molecules & diseases 1997) 2 3 4 22 58
  2. IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1). (PMID: 26334375) Zheng C … Wang H (Cellular signalling 2015) 3 4 58
  3. Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5. (PMID: 25092312) Katibah GE … Collins K (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58
  4. tRNA binding, structure, and localization of the human interferon-induced protein IFIT5. (PMID: 23317505) Katibah GE … Collins K (Molecular cell 2013) 3 4 58
  5. Crystal structure and nucleotide selectivity of human IFIT5/ISG58. (PMID: 23774268) Feng F … Liang H (Cell research 2013) 3 4 58

Products for IFIT5 Gene

  • Addgene plasmids for IFIT5

Sources for IFIT5 Gene

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