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IFIT3 Gene

protein-coding   GIFtS: 50

GC10P091077
interferon-induced protein with tetratricopeptide repeats 3
(Previous name: interferon-induced protein with tetratricopeptide repeats 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IFIT4)
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Aliases &
Descriptions
for IFIT3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CIG-49 1, 2
CIG49 3
GARG-49 1, 2
IFI-60K 3
IFI60 1, 2, 3
IFIT-3 3
IFIT-4 3
IFIT4 2, 3
IRG2 1, 2
ISG-60 3
ISG60 1, 2
OTTHUMP00000020059 2
OTTHUMP00000020060 2
RIG-G 1, 2, 3
Descriptions
Interferon-induced 60 kDa protein 2, 3
Retinoic acid-induced gene G protein 3
interferon-induced protein with tetratricopeptide repeats 3 2
interferon-induced protein with tetratricopeptide repeats 4 1, 2
retinoic acid-induced gene G 2
External Ids
HGNC: 54111
Entrez Gene: 34372
UniProtKB: O148793
Ensembl: ENSG000001199177
Search outside databases for aliases for IFIT3 gene

Previous GC identifer: GC00U990438

Summaries
for IFIT3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 Gene Wiki entry for IFIT3

Genomic Location
for IFIT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFIT3 gene  

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091077:     (about GC identifiers)

Start:
 91,077,733 bp from pter
End:
 91,090,314 bp from pter
Size:
 12,582 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for IFIT3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 3  
Size: 490 amino acids; 55985 Da
Secondary accessions: Q99634 Q9BSK7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001026853.1  NP_001540.2  


    ENSEMBL proteins: 
    ENSP00000360876 ENSP00000360883 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (IFIT3)
    Human Recombinant Proteins from Abnova (IFIT3)
                   OriGene Purified Recombinant Human Proteins (see all 2): IFIT3  

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    About this table

    Antibodies for IFIT3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IFIT3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (IFIT3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (IFIT3)
    Novus Biologicals Antibodies for IFIT3

    Assays for IFIT3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for IFIT3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro domains/families:
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR_region
     IPR019734 TPR_repeat


       GeneDecks  IFIT3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O14879

    ProtoNet protein and cluster: O14879

    UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879
    Similarity: Belongs to the IFIT family
    Similarity: Contains 8 TPR repeats

    Gene Function
    for IFIT3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IFIT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031683

                  Applied Biosystems Silencer® siRNAs for IFIT3

                  Sigma-Aldrich siRNA for IFIT3  
                         Sigma-Aldrich shRNA for IFIT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IFIT3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031683
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031683
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001031683 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001549

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    About this table

    Pathways & Interactions
    for IFIT3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  IFIT3  (Your Favorite Gene powered by Ingenuity) 
     Interferon Signaling

       GeneDecks  IFIT3 for the pathways selected above  
    About GeneDecksing


    5/10 Interacting proteins for IFIT3 (ENSP000003608833 O148792) via UniProtKB, MINT, and/or STRING (see all 10 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC67Q05D602MINT-67722
    IFIT2P099132MINT-66798
    IFIT3O148792MINT-67733
    COPS5ENSP000003505123STRING (score=.971)
    STAT1ENSP000003543943STRING (score=.812)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table

    Drugs & Compounds
    for IFIT3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IFIT3
    1 Novoseek chemical compound relationship for IFIT3 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    higg 87.61 2 12223237 (1), 16146789 (1)
    About this table


    Transcripts
    for IFIT3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IFIT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031683

                  Sigma-Aldrich siRNA for IFIT3  
                         Sigma-Aldrich shRNA for IFIT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001031683  NM_001549  

    REFSEQ mRNAs for IFIT3 gene (2 alternative transcripts): 

    NM_001031683.2   NM_001549.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001031683  NM_001549  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031683
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031683
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001031683 

    Additional cDNA sequence: 

    AF026939.1 AF026943.1 AF083470.1 AK290427.1 AK297137.1 AK312675.1 BC001383.2 BC004977.1 
    BT007284.1 CR618361.1 CR626380.1 U52513.1 

    16 DOTS entries:

    DT.91645862  DT.121275542  DT.121275498  DT.100794177  DT.444369  DT.121275573  DT.100794175  DT.121275404 
    DT.121275419  DT.101977967  DT.95161785  DT.121275501  DT.95094423  DT.92447094  DT.121275416  DT.95161787 

    24/146 AceView cDNA sequences (see all 146 ):

    BU183585 W74319 BM761118 AL711024 AI075407 AL544297 BQ694738 CR626380 
    BM790031 BQ691800 CR618361 BM842372 BU180072 BM847120 BP351337 AA135032 
    BM786488 BU957378 BP346137 BX280425 BU160659 CB121302 BQ691094 BU507901 

    highest scoring ESTs for IFIT3:

    AF026939 AI075407 AA134959 AA991285 AF083470 AI123626 AI610607 AI676218 AI884487 AL544297 

    Unigene Cluster for IFIT3:

    Interferon-induced protein with tetratricopeptide repeats 3
    Hs.714337  [show with all ESTs]
    Unigene Representative Sequence: NM_001549


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000371811  ENST00000371818  

    Expression
    for IFIT3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IFIT3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IFIT3

    1 / 2 / 3

    6 probe-sets matching IFIT3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    62330_at2, 3 U95-C 1 1.00 1.00 0.97 1.15 AI075407 1.00 1.00 1.00 1
    38584_at2, 3 U95-A 1 1.00 1.00 0.94 0.85 AF026939 1.00 1.00 1.00 1

    		229450_at2, 3 U133-B 1 1.00 1.00 -- -- AI075407 1.00 1.00 1.00 1

    		204747_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001549 0.60 1.00 0.82 1

    		229450_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		204747_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  IFIT3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.714337

    Expression variation in blood from EXPOLDB for IFIT3

    Orthologs
    for IFIT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for IFIT3 gene from 3 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    cow
    (Bos taurus)    		 IFIT31   -- interferon-induced protein with tetratricopeptide repeats more 79.68(n)
    72.44(a)    		 509678  NM_001075414.1  NP_001068882.1 
    rat
    (Rattus norvegicus)    		 Ifit31   -- interferon-induced protein with tetratricopeptide repeats more 72.29(n)
    63.33(a)    		 309526  NM_001007694.1  NP_001007695.1 
    mouse
    (Mus musculus)    		 I830012O16Rik1   -- RIKEN cDNA I830012O16 gene 71.65(n)
    61.1(a)    		 667370  XM_001000862.1  XP_001000862.1 
    About this table        Species with no ortholog for IFIT3

    ENSEMBL Gene Tree for IFIT3

    Paralogs
    for IFIT3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IFIT3 gene
    IFIT12  IFIT52  IFIT1L2  IFIT22  

    SNPs/Variants
    for IFIT3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/134 NCBI SNPs in IFIT3 are shown (see all 134 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 72)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs78976191,2
    		A,C,F,H91080531(+) CTCCAC/TAAATA 2 -- ng51 int116Minor allele frequency- N:0.00EU EA WA NA 1418
    --
    rs65861831,2
    		A,C,F,H91081483(+) ctcatT/Cgactg 2 -- int1 ng518Minor allele frequency- C:0.24EU EA WA 838
    rs107496071,2
    		A,C,F,H91089923(+) TAGGAG/CGATAG 2 -- ut31 ese313Minor allele frequency- C:0.21EU EA WA NA 1162
    rs122555041,2
    		A,F,H91082169(+) AGATTC/GTGTTT 2 -- ng51 int14Minor allele frequency- G:0.23EU EA WA 416
    rs78978731,2
    		C,F,H91080689(+) aggacT/CGCATA 2 -- int1 ng514Minor allele frequency- C:0.23EU EA WA 416
    rs105095701,2
    		C,F,H91082211(+) TTCCAT/ACAGTT 2 -- ng51 int116Minor allele frequency- A:0.05NS NA EU EA WA 1082
    rs171196721,2
    		C,F,H91090611(+) TTCAGG/CCATGT 2 -- ut31 ese311Minor allele frequency- C:0.10NA EU EA WA 980
    --
    rs65861821,2
    		A,C91081466(+) tggcaC/Tgtgcc 2 -- ng51 int10--------
    --
    rs112030701,2
    		A,C91081394(+) agttgA/Gagacc 2 -- ng51 int10--------
    rs120984351,2
    		F,H91080468(+) GTCCTG/ATGGTT 2 -- ng51 int14Minor allele frequency- A:0.05EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for IFIT3 (up to first 250kb)

    Disorders & Mutations
    for IFIT3

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604650

    Medical News
    for IFIT3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for IFIT3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/22 PubMed articles for IFIT3 gene (see all 22 ):

    Search for IFIT3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IFIT3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3437 HGNC: 5411 AceView: IFIT3 Ensembl:ENSG00000119917 euGenes: HUgn3437
    ECgene: IFIT3 H-InvDB: IFIT3

    Other Databases showing IFIT3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing IFIT3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for IFIT3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for IFIT3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IFIT3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFIT3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for IFIT3 Antibodies for IFIT3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for IFIT3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (IFIT3)
     Antibodies (IFIT3)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (IFIT3)
     Antibodies (IFIT3)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for IFIT3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for IFIT3

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