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Aliases for IFIT3 Gene

Aliases for IFIT3 Gene

  • Interferon-Induced Protein With Tetratricopeptide Repeats 3 2 3
  • Interferon-Induced Protein With Tetratricopeptide Repeats 4 2 3 4
  • IFIT4 3 4 6
  • Retinoic Acid-Induced Gene G Protein 3 4
  • Interferon-Induced 60 KDa Protein 3 4
  • IFI-60K 3 4
  • CIG-49 3 4
  • IFIT-3 3 4
  • IFIT-4 3 4
  • ISG-60 3 4
  • CIG49 3 4
  • IFI60 3 4
  • ISG60 3 4
  • RIG-G 3 4
  • P60 3 4
  • GARG-49 3
  • IRG2 3

External Ids for IFIT3 Gene

Previous Symbols for IFIT3 Gene

  • IFIT4

Summaries for IFIT3 Gene

GeneCards Summary for IFIT3 Gene

IFIT3 (Interferon-Induced Protein With Tetratricopeptide Repeats 3) is a Protein Coding gene. Diseases associated with IFIT3 include adult dermatomyositis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot for IFIT3 Gene

  • IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Gene Wiki entry for IFIT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT3 Gene

Genomics for IFIT3 Gene

Genomic Location for IFIT3 Gene

Start:
89,327,845 bp from pter
End:
89,340,971 bp from pter
Size:
13,127 bases
Orientation:
Plus strand

Genomic View for IFIT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT3 Gene

Regulatory Elements for IFIT3 Gene

Proteins for IFIT3 Gene

  • Protein details for IFIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14879-IFIT3_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 3
    Protein Accession:
    O14879
    Secondary Accessions:
    • Q99634
    • Q9BSK7

    Protein attributes for IFIT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    55985 Da
    Quaternary structure:
    • Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5.

neXtProt entry for IFIT3 Gene

Proteomics data for IFIT3 Gene at MOPED

Post-translational modifications for IFIT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT3 Gene

Domains for IFIT3 Gene

Gene Families for IFIT3 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFIT3 Gene

Graphical View of Domain Structure for InterPro Entry

O14879

UniProtKB/Swiss-Prot:

IFIT3_HUMAN
Family:
  • Belongs to the IFIT family.:
    • O14879
Similarity:
  • Contains 8 TPR repeats.:
    • O14879
genes like me logo Genes that share domains with IFIT3: view

Function for IFIT3 Gene

Molecular function for IFIT3 Gene

UniProtKB/Swiss-Prot Function: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
UniProtKB/Swiss-Prot Induction: By type I interferons, dsRNAs and viruses.

Gene Ontology (GO) - Molecular Function for IFIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with IFIT3: view

miRNA for IFIT3 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFIT3 Gene

Localization for IFIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT3 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT3 Gene COMPARTMENTS Subcellular localization image for IFIT3 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17050680
GO:0005739 mitochondrion IDA 21813773
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFIT3: view

Pathways for IFIT3 Gene

genes like me logo Genes that share pathways with IFIT3: view

Pathways by source for IFIT3 Gene

Gene Ontology (GO) - Biological Process for IFIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 17050680
GO:0009615 response to virus IMP 21642987
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0035457 cellular response to interferon-alpha IEA --
GO:0043066 negative regulation of apoptotic process IDA 21190939
genes like me logo Genes that share ontologies with IFIT3: view

Compounds for IFIT3 Gene

(1) Novoseek inferred chemical compound relationships for IFIT3 Gene

Compound -log(P) Hits PubMed IDs
higg 87.1 2
genes like me logo Genes that share compounds with IFIT3: view

Transcripts for IFIT3 Gene

Unigene Clusters for IFIT3 Gene

Interferon-induced protein with tetratricopeptide repeats 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT3 Gene

No ASD Table

Relevant External Links for IFIT3 Gene

GeneLoc Exon Structure for
IFIT3
ECgene alternative splicing isoforms for
IFIT3

Expression for IFIT3 Gene

mRNA expression in normal human tissues for IFIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT3 Gene

This gene is overexpressed in Brain - Substantia nigra (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT3 Gene

SOURCE GeneReport for Unigene cluster for IFIT3 Gene Hs.744072

mRNA Expression by UniProt/SwissProt for IFIT3 Gene

O14879-IFIT3_HUMAN
Tissue specificity: Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.
genes like me logo Genes that share expressions with IFIT3: view

Orthologs for IFIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT3 35
  • 99.32 (n)
  • 98.98 (a)
IFIT3 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFIT3 35
  • 79.68 (n)
  • 72.44 (a)
IFIT3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIT3 35
  • 80.33 (n)
  • 72.45 (a)
IFIT3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia I830012O16Rik 35
  • 71.65 (n)
  • 61.1 (a)
I830012O16Rik 36
  • 61 (a)
OneToMany
Ifit3 16
Ifit3 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifit3 35
  • 72.29 (n)
  • 63.33 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 36
  • 27 (a)
ManyToMany
ifit2 36
  • 22 (a)
ManyToMany
ifit5 36
  • 27 (a)
ManyToMany
si:ch211-240h7.2 36
  • 21 (a)
ManyToMany
si:dkey-116m16.3 36
  • 21 (a)
ManyToMany
si:dkey-26g8.10 36
  • 27 (a)
ManyToMany
si:dkey-26g8.11 36
  • 29 (a)
ManyToMany
si:dkey-26g8.12 36
  • 28 (a)
ManyToMany
zgc:123282 36
  • 26 (a)
ManyToMany
Species with no ortholog for IFIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT3 Gene

ENSEMBL:
Gene Tree for IFIT3 (if available)
TreeFam:
Gene Tree for IFIT3 (if available)

Paralogs for IFIT3 Gene

Paralogs for IFIT3 Gene

Selected SIMAP similar genes for IFIT3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFIT3: view

Variants for IFIT3 Gene

Sequence variations from dbSNP and Humsavar for IFIT3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1136864 -- 89,328,047(+) TTTTC(A/G)GAACA utr-variant-5-prime
rs1136865 -- 89,328,052(+) GGAAC(A/T)GCAGA utr-variant-5-prime
rs1136866 -- 89,328,057(+) AGCAG(A/G)GACAC utr-variant-5-prime
rs1136867 -- 89,328,060(+) AGAGA(A/C)ACAGA utr-variant-5-prime
rs1332330 -- 89,329,039(+) TATTG(A/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFIT3 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Relevant External Links for IFIT3 Gene

HapMap Linkage Disequilibrium report
IFIT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT3 Gene

Disorders for IFIT3 Gene

(1) MalaCards Diseases for IFIT3 Gene

Search for IFIT3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for IFIT3 Gene

Relevant External Links for IFIT3

Genetic Association Database (GAD)
IFIT3
Human Genome Epidemiology (HuGE) Navigator
IFIT3
genes like me logo Genes that share disorders with IFIT3: view

No data available for UniProtKB/Swiss-Prot for IFIT3 Gene

Publications for IFIT3 Gene

  1. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. (PMID: 9391139) Zhu H. … Shenk T. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes. (PMID: 9828129) de Veer M.J. … Ralph S.J. (Genomics 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The interferon stimulated gene 54 promotes apoptosis. (PMID: 21190939) Stawowczyk M. … Reich N.C. (J. Biol. Chem. 2011) 3 4
  5. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A. … Superti-Furga G. (Nat. Immunol. 2011) 3 4

Products for IFIT3 Gene

  • Addgene plasmids for IFIT3

Sources for IFIT3 Gene

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