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Aliases for IFIT3 Gene

Aliases for IFIT3 Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 3 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 4 2 3 4
  • Retinoic Acid-Induced Gene G Protein 3 4
  • Interferon-Induced 60 KDa Protein 3 4
  • IFI-60K 3 4
  • CIG-49 3 4
  • IFIT-3 3 4
  • IFIT-4 3 4
  • ISG-60 3 4
  • IFIT4 3 4
  • CIG49 3 4
  • IFI60 3 4
  • ISG60 3 4
  • RIG-G 3 4
  • P60 3 4
  • Interferon-Induced Protein With Tetratricopeptide Repeats 3 2
  • GARG-49 3
  • Cig41 3
  • IRG2 3

External Ids for IFIT3 Gene

Previous HGNC Symbols for IFIT3 Gene

  • IFIT4

Previous GeneCards Identifiers for IFIT3 Gene

  • GC00U990438
  • GC10P091077
  • GC10P084721

Summaries for IFIT3 Gene

GeneCards Summary for IFIT3 Gene

IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune System. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot for IFIT3 Gene

  • IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Gene Wiki entry for IFIT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT3 Gene

Genomics for IFIT3 Gene

Regulatory Elements for IFIT3 Gene

Enhancers for IFIT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFIT3 on UCSC Golden Path with GeneCards custom track

Promoters for IFIT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFIT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFIT3 Gene

Chromosome:
10
Start:
89,327,819 bp from pter
End:
89,340,971 bp from pter
Size:
13,153 bases
Orientation:
Plus strand

Genomic View for IFIT3 Gene

Genes around IFIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT3 Gene

Proteins for IFIT3 Gene

  • Protein details for IFIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14879-IFIT3_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 3
    Protein Accession:
    O14879
    Secondary Accessions:
    • Q99634
    • Q9BSK7

    Protein attributes for IFIT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    55985 Da
    Quaternary structure:
    • Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5.

neXtProt entry for IFIT3 Gene

Proteomics data for IFIT3 Gene at MOPED

Post-translational modifications for IFIT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT3 Gene

No data available for DME Specific Peptides for IFIT3 Gene

Domains & Families for IFIT3 Gene

Gene Families for IFIT3 Gene

Protein Domains for IFIT3 Gene

Graphical View of Domain Structure for InterPro Entry

O14879

UniProtKB/Swiss-Prot:

IFIT3_HUMAN :
  • Belongs to the IFIT family.
  • Contains 8 TPR repeats.
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with IFIT3: view

Function for IFIT3 Gene

Molecular function for IFIT3 Gene

UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
UniProtKB/Swiss-Prot Induction:
By type I interferons, dsRNAs and viruses.
genes like me logo Genes that share phenotypes with IFIT3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFIT3 Gene

Localization for IFIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT3 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT3 Gene COMPARTMENTS Subcellular localization image for IFIT3 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IFIT3 Gene

Pathways & Interactions for IFIT3 Gene

genes like me logo Genes that share pathways with IFIT3: view

Pathways by source for IFIT3 Gene

Gene Ontology (GO) - Biological Process for IFIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus IMP 21642987
GO:0035457 cellular response to interferon-alpha IEA --
GO:0043066 negative regulation of apoptotic process IDA 21190939
GO:0051607 defense response to virus IBA --
genes like me logo Genes that share ontologies with IFIT3: view

No data available for SIGNOR curated interactions for IFIT3 Gene

Drugs & Compounds for IFIT3 Gene

(1) Additional Compounds for IFIT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFIT3: view

Transcripts for IFIT3 Gene

Unigene Clusters for IFIT3 Gene

Interferon-induced protein with tetratricopeptide repeats 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT3 Gene

No ASD Table

Relevant External Links for IFIT3 Gene

GeneLoc Exon Structure for
IFIT3
ECgene alternative splicing isoforms for
IFIT3

Expression for IFIT3 Gene

mRNA expression in normal human tissues for IFIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT3 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.3).

Protein differential expression in normal tissues from HIPED for IFIT3 Gene

This gene is overexpressed in Bone (25.9) and Heart (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT3 Gene



SOURCE GeneReport for Unigene cluster for IFIT3 Gene Hs.744072

mRNA Expression by UniProt/SwissProt for IFIT3 Gene

O14879-IFIT3_HUMAN
Tissue specificity: Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.
genes like me logo Genes that share expression patterns with IFIT3: view

Protein tissue co-expression partners for IFIT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IFIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFIT3 35
  • 79.68 (n)
  • 72.44 (a)
IFIT3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIT3 35
  • 80.33 (n)
  • 72.45 (a)
IFIT3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia I830012O16Rik 35
  • 71.65 (n)
  • 61.1 (a)
Ifit3b 16
I830012O16Rik 36
  • 61 (a)
OneToMany
Ifit3 36
  • 60 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia IFIT3 35
  • 99.32 (n)
  • 98.98 (a)
IFIT3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifit3 35
  • 72.29 (n)
  • 63.33 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 36
  • 27 (a)
ManyToMany
ifit2 36
  • 22 (a)
ManyToMany
ifit5 36
  • 27 (a)
ManyToMany
si:ch211-240h7.2 36
  • 21 (a)
ManyToMany
si:dkey-116m16.3 36
  • 21 (a)
ManyToMany
si:dkey-26g8.10 36
  • 27 (a)
ManyToMany
si:dkey-26g8.11 36
  • 29 (a)
ManyToMany
si:dkey-26g8.12 36
  • 28 (a)
ManyToMany
zgc:123282 36
  • 26 (a)
ManyToMany
Species with no ortholog for IFIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT3 Gene

ENSEMBL:
Gene Tree for IFIT3 (if available)
TreeFam:
Gene Tree for IFIT3 (if available)

Paralogs for IFIT3 Gene

Paralogs for IFIT3 Gene

(4) SIMAP similar genes for IFIT3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFIT3: view

Variants for IFIT3 Gene

Sequence variations from dbSNP and Humsavar for IFIT3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7094510 -- 89,325,902(+) accct(A/G)gttaa upstream-variant-2KB
rs7095398 -- 89,325,850(+) acctg(A/C)acata upstream-variant-2KB
rs11813380 -- 89,329,465(+) TCTGA(A/G)GGGGG intron-variant
rs7897619 -- 89,330,794(+) CTCCA(C/T)AAATA intron-variant, upstream-variant-2KB
rs7897873 -- 89,330,952(+) aggac(C/T)GCATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFIT3 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Variation tolerance for IFIT3 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFIT3 Gene

HapMap Linkage Disequilibrium report
IFIT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT3 Gene

Disorders for IFIT3 Gene

Relevant External Links for IFIT3

Genetic Association Database (GAD)
IFIT3
Human Genome Epidemiology (HuGE) Navigator
IFIT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFIT3

No disorders were found for IFIT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFIT3 Gene

Publications for IFIT3 Gene

  1. IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes. (PMID: 9828129) de Veer M.J. … Ralph S.J. (Genomics 1998) 2 3 4 67
  2. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. (PMID: 9391139) Zhu H. … Shenk T. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3
  3. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. (PMID: 25131332) Zhu X. … Li M. (Cell. Microbiol. 2015) 3
  4. Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype. (PMID: 25650658) Niess H. … Bruns C.J. (Oncotarget 2015) 3
  5. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. (PMID: 25905045) Ezzati P. … Coombs K.M. (Front Cell Infect Microbiol 2015) 3

Products for IFIT3 Gene

Sources for IFIT3 Gene

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