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IFIT3 Gene

protein-coding   GIFtS: 53
GCID: GC10P091077

Interferon-Induced Protein With Tetratricopeptide Repeats...

(Previous name: interferon-induced protein with tetratricopeptide repeats...)
(Previous symbol: IFIT4)
  See IFIT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 31 2     IFIT-32 3
IFIT41 2 3 5     IFIT-42 3
Interferon-Induced Protein With Tetratricopeptide Repeats 41 2 3     ISG-602 3
Interferon-Induced 60 KDa Protein2 3     ISG602 3
Retinoic Acid-Induced Gene G Protein2 3     P602 3
CIG-492 3     RIG-G2 3
CIG492 3     GARG-492
IFI-60K2 3     IRG22
IFI602 3     

External Ids:    HGNC: 54111   Entrez Gene: 34372   Ensembl: ENSG000001199177   OMIM: 6046505   UniProtKB: O148793   

Export aliases for IFIT3 gene to outside databases

Previous GC identifers: GC00U990438 GC10P084721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFIT3 Gene:
IFIT3 (interferon-induced protein with tetratricopeptide repeats 3) is a protein-coding gene. Diseases associated with IFIT3 include adult dermatomyositis, and acute promyelocytic leukemia. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879
Function: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell
migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by
serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and
phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an
antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27.
Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the
cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing
nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can
negatively regulate the apoptotic effects of IFIT2

Gene Wiki entry for IFIT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IFIT3 gene promoter:
         RFX1   STAT1   Nkx6-1   IRF-7A   Evi-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IFIT3 promoter sequence
   Search Chromatin IP Primers for IFIT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091077:  view genomic region     (about GC identifiers)

Start:
91,087,602 bp from pter      End:
91,100,728 bp from pter
Size:
13,127 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 3  
Size: 490 amino acids; 55985 Da
Subunit: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3.
Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5
Secondary accessions: Q99634 Q9BSK7

Explore the universe of human proteins at neXtProt for IFIT3: NX_O14879

Explore proteomics data for IFIT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFIT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001026853.1  NP_001276687.1  NP_001276688.1  NP_001540.2  

    ENSEMBL proteins: 
     ENSP00000360883   ENSP00000360876  
    Reactome Protein details: O14879

    IFIT3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for IFIT3
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    OriGene MassSpec for IFIT3
    OriGene Custom Protein Services for IFIT3
    GenScript Custom Purified and Recombinant Proteins Services for IFIT3
    Novus Biologicals IFIT3 Proteins
    Novus Biologicals IFIT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFIT3

     
    Search eBioscience for Proteins for IFIT3 

    IFIT3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IFIT3 Antibodies
    Abcam antibodies for IFIT3
    Cloud-Clone Corp. Antibodies for IFIT3
    ThermoFisher Antibodies for IFIT3
    LSBio Antibodies in human, mouse, rat for IFIT3

    IFIT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFIT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFIT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFIT3
    Cloud-Clone Corp. CLIAs for IFIT3
    Search eBioscience for ELISAs for IFIT3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR024122 Interferon-induced_IFIT3
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O14879

    ProtoNet protein and cluster: O14879

    UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879
    Similarity: Belongs to the IFIT family
    Similarity: Contains 8 TPR repeats


    Find genes that share domains with IFIT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT3_HUMAN, O14879
    Function: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell
    migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by
    serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and
    phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an
    antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27.
    Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the
    cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing
    nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can
    negatively regulate the apoptotic effects of IFIT2
    Induction: By type I interferons, dsRNAs and viruses

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IPI16189514
         
    Find genes that share ontologies with IFIT3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFIT3:
    hsa-mir-1 (MIRT023767), hsa-mir-124-3p (MIRT022687), hsa-mir-146a-5p (MIRT021277), hsa-mir-92b-3p (MIRT040680)

    Block miRNA regulation of human, mouse, rat IFIT3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFIT3:
    hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidIFIT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFIT3
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFIT3

    Clone
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    OriGene clones in human, mouse for IFIT3 (see all 13)
    OriGene ORF clones in mouse, rat for IFIT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IFIT3 (NM_001031683)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT3
    Addgene plasmids for IFIT3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFIT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFIT3_HUMAN, O14879: Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17050680
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IFIT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFIT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43


    Find genes that share SuperPaths with IFIT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for IFIT3
        Interferon alpha/beta signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT3: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFIT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFIT3 (O148791, 2, 3 ENSP000003608764) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT2P099131, 2, 3, ENSP000003608914EBI-745127,EBI-3507167 MINT-66798 I2D: score=4 STRING: ENSP00000360891
    IFIT1P099141, 3, ENSP000003608694EBI-745127,EBI-745117 I2D: score=4 STRING: ENSP00000360869
    CDC37Q165431, 3EBI-745127,EBI-295634 I2D: score=1 
    IFIT3O148791, 2EBI-745127,EBI-745127 MINT-67733
    CCDC67Q05D602, 3, ENSP000002980504MINT-67722 I2D: score=4 STRING: ENSP00000298050
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IDA17050680
    GO:0009615response to virus IMP--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035457cellular response to interferon-alpha IEA--
    GO:0043066negative regulation of apoptotic process IDA--

    Find genes that share ontologies with IFIT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFIT3

    1 Novoseek inferred chemical compound relationship for IFIT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    higg 87.1 2 12223237 (1), 16146789 (1)



    Find genes that share compounds with IFIT3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFIT3 gene (4 alternative transcripts): 
    NM_001031683.3  NM_001289758.1  NM_001289759.1  NM_001549.5  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371818(uc001kgf.3) ENST00000371811(uc001kgg.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFIT3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFIT3:
    hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidIFIT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFIT3
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT3
    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT3 (see all 13)
    OriGene ORF clones in mouse, rat for IFIT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IFIT3 (NM_001031683)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT3
    Addgene plasmids for IFIT3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFIT3
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT3
      QuantiTect SYBR Green Assays in human, mouse, rat IFIT3
      QuantiFast Probe-based Assays in human, mouse, rat IFIT3

    Selected AceView cDNA sequences (see all 146):

    AA135032 CR618361 BQ694738 BU183585 BM786488 T92735 BM842372 AL544297 
    W74319 BP351337 BU180072 BM847120 BU507901 BX280425 BU509201 BQ691800 
    BU160659 AL711024 BC004977 BM761118 BM790031 BP346137 BU957378 BQ691094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFIT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFIT3 Expression
    About this image


    IFIT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    IFIT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFIT3 Protein Expression

    UniProtKB/Swiss-Prot: IFIT3_HUMAN, O14879
    Tissue specificity: Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes
    from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level).
    Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT3: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFIT3
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT3
    QuantiTect SYBR Green Assays in human, mouse, rat IFIT3
    QuantiFast Probe-based Assays in human, mouse, rat IFIT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit35
    I830012O16Rik1
    interferon-induced protein with tetratricopeptide repeats more5
    RIKEN cDNA I830012O16 gene1
    71.65(n)1
    61.1(a)1
      19 (29.74 cM)5
    6673701  NM_001005858.31  NP_001005858.21 
     345835315 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    many ↔ many
    GL343442.1(880721-891971)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26g8.116
    si:dkey-26g8.126
    (see all 9)
    si:dkey-26g8.12
    (see all 9)
    29(a)
    28(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    12(18092678-18095207) ENSDARG00000007467
    12(18100446-18107181) ENSDARG00000008098


    ENSEMBL Gene Tree for IFIT3 (if available)
    TreeFam Gene Tree for IFIT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFIT3 gene
    IFIT12  IFIT1B2  IFIT52  IFIT22  
    4 SIMAP similar genes for IFIT3 using alignment to 2 protein entries:     IFIT3_HUMAN (see all proteins):
    IFIT2    IFIT1B    IFIT1    IFIT5

    Find genes that share paralogs with IFIT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFIT3 (see all 384)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70953981,2
    C,F,A,H--91085607(+) acctgA/Cacata 1 -- us2k127Minor allele frequency- C:0.36NS EA NA WA CSA 2475
    rs70945101,2
    C,F,A,H--91085659(+) accctA/Ggttaa 1 -- us2k126Minor allele frequency- G:0.26NS EA NA WA CSA 2483
    rs1401375301,2
    --91085783(+) CAGTTC/TGGAGG 1 -- us2k10--------
    rs1432523951,2
    --91085784(+) AGTTCA/GGAGGT 1 -- us2k10--------
    rs1825932621,2
    --91085799(+) CAAAAA/GACTAA 1 -- us2k10--------
    rs1868739281,2
    --91085896(+) ACTCCC/TATGTT 1 -- us2k10--------
    rs1467025561,2
    --91085897(+) CTCCCA/GTGTTT 1 -- us2k10--------
    rs1921864321,2
    --91085948(+) CTAAGC/TGTCCA 1 -- us2k10--------
    rs1400880131,2
    --91085986(+) TGGTAC/TATTTA 1 -- us2k10--------
    rs802429241,2
    C--91086102(+) AACAAG/TGTTTG 1 -- us2k13Minor allele frequency- T:0.17NA 6

    HapMap Linkage Disequilibrium report for IFIT3 (91087602 - 91100728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFIT3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604650    OMIM disorders: --

    2 diseases for IFIT3:    
    About MalaCards
    adult dermatomyositis    acute promyelocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for IFIT3:
    Adult dermatomyositis

    Find genes that share disorders with IFIT3           About GenesLikeMe

    Genetic Association Database (GAD): IFIT3
    Human Genome Epidemiology (HuGE) Navigator: IFIT3 (1 document)

    Export disorders for IFIT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFIT3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with IFIT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes. (PubMed id 9828129)1, 2, 3 de Veer M.J.... Ralph S.J. (Genomics 1998)
    2. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. (PubMed id 9391139)1, 2, 3 Zhu H.... Shenk T. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. (PubMed id 21813773)1, 2 Liu X.Y.... Wang C. (J. Immunol. 2011)
    4. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    5. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. (PubMed id 20686046)1, 2 Schmeisser H.... Zoon K.C. (J. Virol. 2010)
    6. Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells. (PubMed id 18706081)1, 2 Huang X.... Chen S. (Arthritis Res. Ther. 2008)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. (PubMed id 17050680)1, 2 Xiao S.... Tong J.H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex. (PubMed id 23415865)1 Xu G.P....Tong J.H. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3437 HGNC: 5411 AceView: IFIT3 Ensembl:ENSG00000119917 euGenes: HUgn3437
    ECgene: IFIT3 H-InvDB: IFIT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IFIT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFIT3 gene:
    Search GeneIP for patents involving IFIT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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