Aliases for IFIT2 Gene
External Ids for IFIT2 Gene
Previous Symbols for IFIT2 Gene
GeneCards Summary for IFIT2 Gene
IFIT2 (Interferon-Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Diseases associated with IFIT2 include ebola hemorrhagic fever. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT1.
UniProtKB/Swiss-Prot for IFIT2 Gene
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2-O-methylation of the 5 cap. The ribose 2-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5 triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.