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IFIT2 Gene

protein-coding   GIFtS: 57

GC10P091051
interferon-induced protein with tetratricopeptide repeats 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: IFI54, G10P2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
G10P2 2, 3, 5
GARG-39 1, 2
IFI-54 1, 2
IFI-54K 3
IFI54 2, 3, 5
IFIT-2 3
ISG-54K 1, 2
ISG54 2
OTTHUMP00000020058 2
cig42 1, 2
Descriptions
ISG-54 K 3
Interferon, alpha-inducible protein (MW 54kD) 2
Interferon-induced 54 kDa protein 3
interferon-induced protein 54 2
interferon-induced protein with tetratricopeptide repeats 2 2
External Ids
HGNC: 54091
Entrez Gene: 34332
UniProtKB: P099133
Ensembl: ENSG000001199227
Search outside databases for aliases for IFIT2 gene

Previous GC identifers: GC10U990034 GC10P090283 GC10P091192 GC10P090726

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for IFIT2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFIT2 gene  

Entrez Gene cytogenetic band: 10q23-q25   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23-q25

IFIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091051:     (about GC identifiers)

Start:
91,051,686 bp from pter
End:
91,059,013 bp from pter
Size:
7,328 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 2  
Size: 472 amino acids; 54632 Da
Secondary accessions: Q5T767

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001538.4  

    ENSEMBL proteins: 
    ENSP00000360891 ENSP00000238977 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (IFIT2)
    Human Recombinant Proteins from Abnova (IFIT2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0043231 intracellular membrane-bounded organelle IDA18029348
    About this table

    Antibodies for IFIT2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IFIT2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (IFIT2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (IFIT2)
    Novus Biologicals Antibody for IFIT2

    Assays for IFIT2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013026 TPR_region
     IPR019734 TPR_repeat


       GeneDecks  IFIT2 for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry P09913

    ProtoNet protein and cluster: P09913

    UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
    Similarity: Belongs to the IFIT family
    Similarity: Contains 6 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (IFIT2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001547

                  Applied Biosystems Silencer® siRNAs for IFIT2

                  Sigma-Aldrich siRNA for IFIT2  
                         Sigma-Aldrich shRNA for IFIT2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IFIT2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001547
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001547
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001547 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001547

    UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
    Induction: By interferons

    Genatlas biochemistry entry for IFIT2:
    interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon
    beta,interleukin 1,retinoic acid,viral infections...
    1 MGI phenotypic allele for Ifit2 (no phenotypes)

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for IFIT2 (Maps provided by GeneGo):
     IFN alpha/beta signaling pathway

       GeneDecks  IFIT2 for the pathways selected above  
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    1 Millipore Pathway for IFIT2
     Immune response IFN alpha/beta signaling pathway

       GeneDecks  IFIT2 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  IFIT2  (Your Favorite Gene powered by Ingenuity) 
     Activation of IRF by Cytosolic Pattern Recognition Receptors

       GeneDecks  IFIT2 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  IFIT2 


    5/11 Interacting proteins for IFIT2 (ENSP000003608913 P099132) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148792MINT-66798
    STAT2ENSP000003157683STRING (score=.97)
    EIF3CENSP000003326043STRING (score=.919)
    SOAT1ENSP000003565913STRING (score=.915)
    TRAF6ENSP000003378533STRING (score=.877)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IFIT2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (IFIT2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001547

                  Sigma-Aldrich siRNA for IFIT2  
                         Sigma-Aldrich shRNA for IFIT2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001547  

    REFSEQ mRNAs for IFIT2 gene: 

    NM_001547.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001547  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001547
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001547
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001547 

    Additional cDNA sequence: 

    AF026944.1 AK300431.1 AK312831.1 BC005987.1 BC032839.2 

    7 DOTS entries:

    DT.121275540  DT.444085  DT.121275562  DT.100775785  DT.121275545  DT.100775784  DT.95262075 

    24/101 AceView cDNA sequences (see all 101 ):

    BU677511 BU167935 CD366645 AA810945 AI373569 BP356603 AA866128 CA306219 
    AW337373 AI458848 AI140291 AI620542 N63988 BI494104 AI446658 BQ946250 
    BQ893557 AI338018 CA391802 CA440164 BU508131 AI301531 AA854597 AV660046 

    highest scoring ESTs for IFIT2:

    AA131041 AA054658 AA056431 AA130252 AA131155 AA134105 AA143609 AA148160 AA484050 AA516150 

    Unigene Cluster for IFIT2:

    Interferon-induced protein with tetratricopeptide repeats 2
    Hs.437609  [show with all ESTs]
    Unigene Representative Sequence: NM_001547


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000371826  ENST00000238977  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IFIT2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IFIT2

    1 / 2 / 3

    7 probe-sets matching IFIT2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    91313_at2, 3 U95-E 1 1.00 1.00 0.80 1.46 AA131041 1.00 1.00 1.00 1

    908_at2, 3 U95-A 1 1.00 1.00 0.84 0.89 M14660 0.20 1.00 0.72 1

    909_g_at2, 3 U95-A 2 1.00 0.97 0.91 0.67 M14660 0.20 1.00 0.72 1

    226757_at2, 3 U133-B 1 1.00 1.00 -- -- AA131041 1.00 1.00 1.00 1

    217502_at2, 3 U133-A 1 0.91 1.00 -- -- BE888744 0.80 1.00 0.91 1

    226757_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217502_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    GeneDecks  IFIT2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTTTTTAAA

    SOURCE GeneReport for Unigene cluster: Hs.437609

    Expression variation in blood from EXPOLDB for IFIT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for IFIT2 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    IFIT21   -- interferon-induced protein with tetratricopeptide repeats more 78.84(n)
    71.52(a)
    479183  XM_536324.2  XP_536324.2 
    chimpanzee
    (Pan troglodytes)
    IFIT21   -- interferon-induced protein with tetratricopeptide repeats more 99.51(n)
    99.15(a)
    450585  XM_507902.2  XP_507902.2 
    rat
    (Rattus norvegicus)
    Ifit21   -- interferon-induced protein with tetratricopeptide repeats more 74.04(n)
    62.69(a)
    294091  NM_001024753.1  NP_001019924.1 
    mouse
    (Mus musculus)
    Ifit21, 5 195
    interferon-induced protein with tetratricopeptide repeats more1, 5 74.84(n)1
    63.77(a)1
    159581  NM_008332.21  NP_032358.11 
     AK0380275  AK0423665  (see all 16)
    About this table        Species with no ortholog for IFIT2

    ENSEMBL Gene Tree for IFIT2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IFIT2 gene
    IFIT12  IFIT32  IFIT52  IFIT1L2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/48 NCBI SNPs in IFIT2 are shown (see all 48 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 37)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs20708451,2
    A,C,F,H,O91056055(+) GGTGAA/GACATG 1 K/R mis116Minor allele frequency- N:0.00EA NA EU WA 1414
    rs49344701,2
    A,C,F,H91057418(+) TAATCC/TACTGG 1 -- ut31 ese35Minor allele frequency- T:0.12NA EU WA 348
    rs17271,2
    A,C,F,H91056749(+) GAAGAA/CGCAGA 1 D/E mis125Minor allele frequency- C:0.09NS MN NA EU EA WA 2076
    rs174687391,2
    C,F,H91055929(+) TGAAGA/CGTTAA 1 E/A mis1 ese315Minor allele frequency- C:0.04NA EU EA WA 1394
    rs37400271,2
    C,F,H91059116(+) TTCAAG/TAGGCC 1 -- ng318Minor allele frequency- T:0.18EA NA EU WA 2052
    rs49335041,2
    A,C,F91057575(+) GCTGGG/CGGACC 1 -- ut31 ese33Minor allele frequency- C:0.25NA 138
    rs38980751,2
    C,H91056613(+) AATGTA/GTGGGA 1 Y/C mis15Minor allele frequency- G:0.00MN EU EA WA 590
    rs37400281,2
    F,H91059284(+) GAGTGG/AAAGGT 1 -- ng315Minor allele frequency- A:0.03EA EU WA 1912
    rs9544401,2
    C,H91056269(+) TCTCAG/TAACGC 1 Q/H mis1 ese35Minor allele frequency- T:0.00MN EU EA WA 604
    rs127684451,2
    H91059354(+) ATGGAT/AGTATG 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for IFIT2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 147040

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for IFIT2 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 3433 HGNC: 5409 AceView: IFIT2 Ensembl:ENSG00000119922 euGenes: HUgn3433
    ECgene: IFIT2 H-InvDB: IFIT2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IFIT2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFIT2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for IFIT2 Antibodies for IFIT2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for IFIT2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search OriGene for IFIT2
     Search Tocris compounds for IFIT2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for IFIT2

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