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Aliases for IFIT2 Gene

Aliases for IFIT2 Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 2 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 2 2 3
  • Interferon-Induced 54 KDa Protein 3 4
  • ISG-54 K 3 4
  • IFI-54K 3 4
  • IFIT-2 3 4
  • G10P2 3 4
  • IFI54 3 4
  • ISG54 3 4
  • P54 3 4
  • Interferon, Alpha-Inducible Protein (MW 54kD) 3
  • Interferon-Induced Protein 54 3
  • GARG-39 3
  • ISG-54K 3
  • IFI-54 3
  • CIG-42 4
  • Cig42 3

External Ids for IFIT2 Gene

Previous HGNC Symbols for IFIT2 Gene

  • IFI54
  • G10P2

Previous GeneCards Identifiers for IFIT2 Gene

  • GC10U990034
  • GC10P090283
  • GC10P091192
  • GC10P090726
  • GC10P091051
  • GC10P084695

Summaries for IFIT2 Gene

GeneCards Summary for IFIT2 Gene

IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Among its related pathways are Type II interferon signaling (IFNG) and Interferon gamma signaling. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is IFIT3.

UniProtKB/Swiss-Prot for IFIT2 Gene

  • IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2-O-methylation of the 5 cap. The ribose 2-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5 triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Gene Wiki entry for IFIT2 Gene

Additional gene information for IFIT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT2 Gene

Genomics for IFIT2 Gene

Regulatory Elements for IFIT2 Gene

Enhancers for IFIT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H089295 1.4 FANTOM5 Ensembl ENCODE dbSUPER 40.8 +12.8 12832 3 CEBPB MAX CEBPG HNF4A PRDM1 IFIT3 IFIT2 IFIT5 IFIT1 IFIT1B FAS ENSG00000232110 LOC105378419
GH10H089163 1.3 FANTOM5 Ensembl ENCODE 38.8 -119.8 -119762 1 MAX RELA ZNF664 EED ETV6 ATF7 RUNX3 IKZF2 CREM HLF IFIT3 IFIT2 IFIT5 IFIT1 CH25H ANKRD22 FAS GC10P089171 LOC100289238
GH10H089337 1.3 FANTOM5 ENCODE dbSUPER 24.2 +53.8 53787 1 ZNF639 ZBTB21 KLF17 JUNB BATF JUND ZNF366 GLIS1 EED ZNF629 IFIT5 IFIT2 IFIT3 IFIT1B ENSG00000232110 IFIT1 LOC101926887
GH10H089260 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -21.2 -21171 5 ARID4B BATF RAD21 ZEB1 RFX5 GATA2 ZNF143 RCOR1 FOS THAP11 IFIT3 IFIT2 IFIT1 IFIT1B SLC16A12-AS1 IFIT5 ENSG00000232110 GC10P089210
GH10H089234 1 FANTOM5 ENCODE dbSUPER 23.6 -48.5 -48456 1 MAX EGR2 IFIT3 IFIT2 IFIT5 IFIT1 ANKRD22 FAS GC10P089210
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFIT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFIT2 Gene

Chromosome:
10
Start:
89,283,694 bp from pter
End:
89,309,276 bp from pter
Size:
25,583 bases
Orientation:
Plus strand

Genomic View for IFIT2 Gene

Genes around IFIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT2 Gene

Proteins for IFIT2 Gene

  • Protein details for IFIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09913-IFIT2_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 2
    Protein Accession:
    P09913
    Secondary Accessions:
    • Q5T767

    Protein attributes for IFIT2 Gene

    Size:
    472 amino acids
    Molecular mass:
    54632 Da
    Quaternary structure:
    • Domain-swapped homodimer. Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT3. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E and EIF3C.

    Three dimensional structures from OCA and Proteopedia for IFIT2 Gene

neXtProt entry for IFIT2 Gene

Post-translational modifications for IFIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT2 Gene

Domains & Families for IFIT2 Gene

Gene Families for IFIT2 Gene

Protein Domains for IFIT2 Gene

Graphical View of Domain Structure for InterPro Entry

P09913

UniProtKB/Swiss-Prot:

IFIT2_HUMAN :
  • The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface.
  • Belongs to the IFIT family.
Domain:
  • The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface.
Family:
  • Belongs to the IFIT family.
genes like me logo Genes that share domains with IFIT2: view

Function for IFIT2 Gene

Molecular function for IFIT2 Gene

GENATLAS Biochemistry:
interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin 1,retinoic acid,viral infections...
UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2-O-methylation of the 5 cap. The ribose 2-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5 triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
UniProtKB/Swiss-Prot Induction:
By type I interferons, dsRNAs and viruses.

Phenotypes From GWAS Catalog for IFIT2 Gene

Gene Ontology (GO) - Molecular Function for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 19416887
genes like me logo Genes that share ontologies with IFIT2: view
genes like me logo Genes that share phenotypes with IFIT2: view

Animal Models for IFIT2 Gene

MGI Knock Outs for IFIT2:

Animal Model Products

CRISPR Products

miRNA for IFIT2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IFIT2
  • Applied Biological Materials Clones for IFIT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFIT2 Gene

Localization for IFIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT2 Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFIT2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 21190939
GO:0005783 endoplasmic reticulum IDA,IEA 21190939
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFIT2: view

Pathways & Interactions for IFIT2 Gene

genes like me logo Genes that share pathways with IFIT2: view

Pathways by source for IFIT2 Gene

1 GeneGo (Thomson Reuters) pathway for IFIT2 Gene

Gene Ontology (GO) - Biological Process for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008637 apoptotic mitochondrial changes TAS 21190939
GO:0009615 response to virus IDA,IMP 21642987
GO:0032091 negative regulation of protein binding IDA 19416887
GO:0035457 cellular response to interferon-alpha IEA --
genes like me logo Genes that share ontologies with IFIT2: view

No data available for SIGNOR curated interactions for IFIT2 Gene

Drugs & Compounds for IFIT2 Gene

No Compound Related Data Available

Transcripts for IFIT2 Gene

mRNA/cDNA for IFIT2 Gene

Unigene Clusters for IFIT2 Gene

Interferon-induced protein with tetratricopeptide repeats 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IFIT2
  • Applied Biological Materials Clones for IFIT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT2 Gene

No ASD Table

Relevant External Links for IFIT2 Gene

GeneLoc Exon Structure for
IFIT2
ECgene alternative splicing isoforms for
IFIT2

Expression for IFIT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFIT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT2 Gene

This gene is overexpressed in Brain - Substantia nigra (x7.6) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for IFIT2 Gene

This gene is overexpressed in Spleen (14.2), Lymph node (9.8), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFIT2 Gene



Protein tissue co-expression partners for IFIT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFIT2 Gene:

IFIT2

SOURCE GeneReport for Unigene cluster for IFIT2 Gene:

Hs.437609

Evidence on tissue expression from TISSUES for IFIT2 Gene

  • Blood(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with IFIT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFIT2 Gene

Orthologs for IFIT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT2 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia IFIT2 33 34
  • 82.1 (n)
dog
(Canis familiaris)
Mammalia IFIT2 33 34
  • 78.93 (n)
mouse
(Mus musculus)
Mammalia Ifit2 33 16 34
  • 74.69 (n)
rat
(Rattus norvegicus)
Mammalia Ifit2 33
  • 73.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ifit5 34
  • 30 (a)
ManyToMany
si:dkey-26g8.11 34
  • 30 (a)
ManyToMany
si:dkey-26g8.10 34
  • 29 (a)
ManyToMany
zgc:123282 34
  • 29 (a)
ManyToMany
CR759879.1 34
  • 28 (a)
ManyToMany
ifit2 34
  • 24 (a)
ManyToMany
si:dkey-116m16.3 34
  • 23 (a)
ManyToMany
si:ch211-240h7.2 34
  • 22 (a)
ManyToMany
Species where no ortholog for IFIT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT2 Gene

ENSEMBL:
Gene Tree for IFIT2 (if available)
TreeFam:
Gene Tree for IFIT2 (if available)

Paralogs for IFIT2 Gene

Paralogs for IFIT2 Gene

(4) SIMAP similar genes for IFIT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IFIT2: view

Variants for IFIT2 Gene

Sequence variations from dbSNP and Humsavar for IFIT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000666231 -- 89,305,208(+) AAAAT(A/G)AGTAA intron-variant
rs1000773546 -- 89,305,844(+) AAGGG(C/G)AGTTT intron-variant
rs1000839336 -- 89,307,595(+) CACGG(A/G)CTTGG intron-variant, utr-variant-3-prime
rs1001122810 -- 89,304,040(+) CCATG(C/G)TCCTG intron-variant
rs1001486394 -- 89,309,658(+) TCCCT(C/T)GCTGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFIT2 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV loss 18971310

Variation tolerance for IFIT2 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFIT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFIT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT2 Gene

Disorders for IFIT2 Gene

Relevant External Links for IFIT2

Genetic Association Database (GAD)
IFIT2
Human Genome Epidemiology (HuGE) Navigator
IFIT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFIT2

No disorders were found for IFIT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFIT2 Gene

Publications for IFIT2 Gene

  1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PMID: 3360121) Wathelet MG … Huez GA (FEBS letters 1988) 2 3 4 60
  2. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. (PMID: 22825553) Yang Z … Liu Y (Cell research 2012) 3 4 60
  3. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A … Superti-Furga G (Nature immunology 2011) 3 4 60
  4. The interferon stimulated gene 54 promotes apoptosis. (PMID: 21190939) Stawowczyk M … Reich NC (The Journal of biological chemistry 2011) 3 4 60
  5. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. (PMID: 19416887) Li Y … Shu HB (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 60

Products for IFIT2 Gene

  • Addgene plasmids for IFIT2

Sources for IFIT2 Gene

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