Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFIT2 Gene

Aliases for IFIT2 Gene

  • Interferon-Induced Protein With Tetratricopeptide Repeats 2 2 3
  • G10P2 3 4 6
  • IFI54 3 4 6
  • Interferon-Induced 54 KDa Protein 3 4
  • ISG-54 K 3 4
  • IFI-54K 3 4
  • IFIT-2 3 4
  • ISG54 3 4
  • P54 3 4
  • Interferon, Alpha-Inducible Protein (MW 54kD) 3
  • Interferon-Induced Protein 54 3
  • GARG-39 3
  • ISG-54K 3
  • IFI-54 3
  • CIG-42 4
  • Cig42 3

External Ids for IFIT2 Gene

Previous Symbols for IFIT2 Gene

  • IFI54
  • G10P2

Summaries for IFIT2 Gene

GeneCards Summary for IFIT2 Gene

IFIT2 (Interferon-Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Diseases associated with IFIT2 include ebola hemorrhagic fever. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot for IFIT2 Gene

  • IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2-O-methylation of the 5 cap. The ribose 2-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5 triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Gene Wiki entry for IFIT2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT2 Gene

Genomics for IFIT2 Gene

Genomic Location for IFIT2 Gene

Start:
89,301,949 bp from pter
End:
89,309,276 bp from pter
Size:
7,328 bases
Orientation:
Plus strand

Genomic View for IFIT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT2 Gene

Regulatory Elements for IFIT2 Gene

Proteins for IFIT2 Gene

  • Protein details for IFIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09913-IFIT2_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 2
    Protein Accession:
    P09913
    Secondary Accessions:
    • Q5T767

    Protein attributes for IFIT2 Gene

    Size:
    472 amino acids
    Molecular mass:
    54632 Da
    Quaternary structure:
    • Domain-swapped homodimer. Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT3. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E and EIF3C.

    Three dimensional structures from OCA and Proteopedia for IFIT2 Gene

neXtProt entry for IFIT2 Gene

Proteomics data for IFIT2 Gene at MOPED

Post-translational modifications for IFIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT2 Gene

Domains for IFIT2 Gene

Gene Families for IFIT2 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFIT2 Gene

UniProtKB/Swiss-Prot:

IFIT2_HUMAN
Domain:
  • The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface:
    • P09913
Family:
  • Belongs to the IFIT family.:
    • P09913
Similarity:
  • Contains 9 TPR repeats.:
    • P09913
genes like me logo Genes that share domains with IFIT2: view

Function for IFIT2 Gene

Molecular function for IFIT2 Gene

GENATLAS Biochemistry: interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin 1,retinoic acid,viral infections...
UniProtKB/Swiss-Prot Function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2-O-methylation of the 5 cap. The ribose 2-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5 triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
UniProtKB/Swiss-Prot Induction: By type I interferons, dsRNAs and viruses.

Gene Ontology (GO) - Molecular Function for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19416887
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with IFIT2: view

Phenotypes for IFIT2 Gene

genes like me logo Genes that share phenotypes with IFIT2: view

Animal Models for IFIT2 Gene

MGI Knock Outs for IFIT2:

miRNA for IFIT2 Gene

miRTarBase miRNAs that target IFIT2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFIT2 Gene

Localization for IFIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT2 Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT2 Gene COMPARTMENTS Subcellular localization image for IFIT2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21190939
GO:0005783 endoplasmic reticulum IDA 21190939
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFIT2: view

Pathways for IFIT2 Gene

genes like me logo Genes that share pathways with IFIT2: view

Pathways by source for IFIT2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for IFIT2 Gene
1 BioSystems pathway for IFIT2 Gene

Gene Ontology (GO) - Biological Process for IFIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008637 apoptotic mitochondrial changes TAS 21190939
GO:0009615 response to virus IMP 21642987
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032091 negative regulation of protein binding IDA 19416887
GO:0035457 cellular response to interferon-alpha IEA --
genes like me logo Genes that share ontologies with IFIT2: view

Transcripts for IFIT2 Gene

mRNA/cDNA for IFIT2 Gene

Unigene Clusters for IFIT2 Gene

Interferon-induced protein with tetratricopeptide repeats 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT2 Gene

No ASD Table

Relevant External Links for IFIT2 Gene

GeneLoc Exon Structure for
IFIT2
ECgene alternative splicing isoforms for
IFIT2

Expression for IFIT2 Gene

mRNA expression in normal human tissues for IFIT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT2 Gene

This gene is overexpressed in Brain - Substantia nigra (7.6) and Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT2 Gene

SOURCE GeneReport for Unigene cluster for IFIT2 Gene Hs.437609

genes like me logo Genes that share expressions with IFIT2: view

Orthologs for IFIT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT2 36
  • 99.51 (n)
  • 99.15 (a)
IFIT2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFIT2 36
  • 82.1 (n)
  • 75.76 (a)
IFIT2 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIT2 36
  • 78.93 (n)
  • 71.65 (a)
IFIT2 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifit2 36
  • 74.69 (n)
  • 63.77 (a)
Ifit2 16
Ifit2 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifit2 36
  • 73.97 (n)
  • 62.47 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 27 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 37
  • 28 (a)
ManyToMany
ifit2 37
  • 24 (a)
ManyToMany
ifit5 37
  • 30 (a)
ManyToMany
si:ch211-240h7.2 37
  • 22 (a)
ManyToMany
si:dkey-116m16.3 37
  • 23 (a)
ManyToMany
si:dkey-26g8.10 37
  • 29 (a)
ManyToMany
si:dkey-26g8.11 37
  • 30 (a)
ManyToMany
zgc:123282 37
  • 29 (a)
ManyToMany
Species with no ortholog for IFIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT2 Gene

ENSEMBL:
Gene Tree for IFIT2 (if available)
TreeFam:
Gene Tree for IFIT2 (if available)

Paralogs for IFIT2 Gene

Paralogs for IFIT2 Gene

Selected SIMAP similar genes for IFIT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IFIT2: view

Variants for IFIT2 Gene

Sequence variations from dbSNP and Humsavar for IFIT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1727 - 89,307,012(+) GAAGA(A/C)GCAGA missense, reference
rs954439 -- 89,306,703(+) GATGT(A/T)CTTCG synonymous-codon, reference
rs954440 -- 89,306,532(+) TCTCA(G/T)AACGC reference, missense
rs1537289 -- 89,304,266(+) CCAGG(C/T)GCGGG intron-variant
rs2070845 - 89,306,318(+) GGTGA(A/G)ACATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFIT2 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Relevant External Links for IFIT2 Gene

HapMap Linkage Disequilibrium report
IFIT2

Disorders for IFIT2 Gene

(1) MalaCards Diseases for IFIT2 Gene

Search for IFIT2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for IFIT2 Gene

Relevant External Links for IFIT2

Genetic Association Database (GAD)
IFIT2
Human Genome Epidemiology (HuGE) Navigator
IFIT2
genes like me logo Genes that share disorders with IFIT2: view

No data available for UniProtKB/Swiss-Prot for IFIT2 Gene

Publications for IFIT2 Gene

  1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PMID: 3360121) Wathelet M.G. … Huez G.A. (FEBS Lett. 1988) 2 3 4
  2. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (PMID: 3466167) Levy D. … Darnell J.E. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  3. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PMID: 1377167) Lafage M. … Huez G. (Genomics 1992) 3 23
  4. [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]. (PMID: 12708317) Gavrilov B.G. … Sverdlov E.D. (Bioorg. Khim. 2003) 3 23
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for IFIT2 Gene

  • Addgene plasmids for IFIT2

Sources for IFIT2 Gene

Back to Top

Content