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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFIT2 Gene

protein-coding   GIFtS: 62
GCID: GC10P091051

Interferon-Induced Protein With Tetratricopeptide Repeats...


(Previous symbols: IFI54, G10P2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 21 2     ISG-54 K2 3
G10P21 2 3 5     GARG-392
IFI541 2 3 5     IFI-542
Interferon-Induced 54 KDa Protein2 3     ISG-54K2
IFI-54K2 3     cig422
IFIT-22 3     Interferon, Alpha-Inducible Protein (MW 54kD)2
ISG542 3     Interferon-Induced Protein 542
P542 3     CIG-423

External Ids:    HGNC: 54091   Entrez Gene: 34332   Ensembl: ENSG000001199227   OMIM: 1470405   UniProtKB: P099133   

Export aliases for IFIT2 gene to outside databases

Previous GC identifers: GC10U990034 GC10P090283 GC10P091192 GC10P090726 GC10P084695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFIT2 Gene: 
IFIT2 (interferon-induced protein with tetratricopeptide repeats 2) is a protein-coding gene. Diseases associated with IFIT2 include ebola hemorrhagic fever, and tick-borne encephalitis, and among its related super-pathways are Immune response IFN alpha/beta signaling pathway and Interferon Signaling. GO annotations related to this gene include protein binding and RNA binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
Function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation
of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and
non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system
such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation
(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is
required for antiviral activity. Can promote apoptosis

Gene Wiki entry for IFIT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFIT2 gene promoter:
         Spz1   IRF-1   Evi-1   C/EBPalpha   FOXL1   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFIT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091051:  view genomic region     (about GC identifiers)

Start:
91,061,706 bp from pter      End:
91,069,033 bp from pter
Size:
7,328 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 2  
Size: 472 amino acids; 54632 Da
Subunit: Domain-swapped homodimer. Component of an interferon-dependent multiprotein complex, at least composed of
IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT3. Interacts with TMEM173/MITA and disrupts its interaction
with MAVS or TBK1. Interacts with EIF3E and EIF3C
Subcellular location: Cytoplasm. Endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for IFIT2:
4G1T (3D)    
Secondary accessions: Q5T767

Explore the universe of human proteins at neXtProt for IFIT2: NX_P09913

Explore proteomics data for IFIT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09913

  • IFIT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFIT2 Protein Expression
    REFSEQ proteins: NP_001538.4  
    ENSEMBL proteins: 
     ENSP00000360891  
    Reactome Protein details: P09913
    Human Recombinant Protein Products for IFIT2: 
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    OriGene Purified Protein for IFIT2
    OriGene Protein Over-expression Lysate for IFIT2
    OriGene MassSpec for IFIT2 
    OriGene Custom Protein Services for IFIT2
    GenScript Custom Purified and Recombinant Proteins Services for IFIT2
    Novus Biologicals IFIT2 Protein
    Novus Biologicals IFIT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFIT2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol TAS--

    IFIT2 for ontologies           About GeneDecksing



    IFIT2 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for IFIT2 
    ThermoFisher Antibody for IFIT2
    LSBio Antibodies in human, mouse, rat for IFIT2 

    Assay Products for IFIT2: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IFIT2
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    Cloud-Clone Corp. ELISAs for IFIT2 
    Cloud-Clone Corp. CLIAs for IFIT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR024124 Interferon-induced_IFIT2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P09913

    ProtoNet protein and cluster: P09913

    UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
    Domain: The C-terminal part folds into a super-helical structure and has an extensively positively-charged
    nucleotide-binding channel on its inner surface
    Similarity: Belongs to the IFIT family
    Similarity: Contains 9 TPR repeats


    IFIT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT2_HUMAN, P09913
    Function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation
    of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and
    non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system
    such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation
    (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is
    required for antiviral activity. Can promote apoptosis
    Induction: By type I interferons, dsRNAs and viruses

         Genatlas biochemistry entry for IFIT2:
    interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin
    1,retinoic acid,viral infections...

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19416887
         
    IFIT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFIT2:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ifit2):
     behavior/neurological  homeostasis/metabolism  immune system  mortality/aging 

    IFIT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IFIT2: Ifit2tm1.1Ebsb Ifit2tm1.1Tac

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFIT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFIT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFIT2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFIT2 (see all 9):
    hsa-miR-627 hsa-miR-589* hsa-let-7a-2* hsa-miR-133b hsa-miR-374c hsa-miR-133a hsa-miR-655 hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidIFIT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFIT2
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IFIT2 (see all 7)
    OriGene ORF clones in mouse, rat for IFIT2
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    GenScript: all cDNA clones in your preferred vector: IFIT2 (NM_001547)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT2
    Sirion Biotech Customized lentivirus for stable overexpression of IFIT2 
                         Customized lentivirus expression plasmids for stable overexpression of IFIT2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IFIT2
    Search LifeMap BioReagents cell lines for IFIT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFIT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    2Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    3Immune System
    Immune System0.56
    4Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IFIT2
        Immune response IFN alpha/beta signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for IFIT2
        Immune response IFN alpha/beta signaling pathway

    1 BioSystems Pathway for IFIT2
        Type II interferon signaling (IFNG)

    4        Reactome Pathways for IFIT2
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    IFIT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFIT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for IFIT2 (P099131, 2, 3 ENSP000003608914) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148791, 2, 3, ENSP000003608764EBI-3507167,EBI-745127 MINT-66798 I2D: score=4 STRING: ENSP00000360876
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    IFIT1P099141, ENSP000003608694EBI-3507167,EBI-745117 STRING: ENSP00000360869
    KRT18P057833I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008637apoptotic mitochondrial changes TAS--
    GO:0009615response to virus IMP--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032091negative regulation of protein binding IDA19416887
    GO:0035457cellular response to interferon-alpha IEA--

    IFIT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFIT2

    Search CenterWatch for drugs/clinical trials and news about IFIT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFIT2 gene: 
    NM_001547.4  

    Unigene Cluster for IFIT2:

    Interferon-induced protein with tetratricopeptide repeats 2
    Hs.437609  [show with all ESTs]
    Unigene Representative Sequence: NM_001547
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371826(uc009xts.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFIT2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFIT2 (see all 9):
    hsa-miR-627 hsa-miR-589* hsa-let-7a-2* hsa-miR-133b hsa-miR-374c hsa-miR-133a hsa-miR-655 hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidIFIT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFIT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFIT2
    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT2 (see all 7)
    OriGene ORF clones in mouse, rat for IFIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT2 (NM_001547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT2
    Sirion Biotech Customized lentivirus for stable overexpression of IFIT2 
                         Customized lentivirus expression plasmids for stable overexpression of IFIT2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFIT2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT2

    Additional mRNA sequence: 

    AF026944.1 AK300431.1 AK312831.1 BC005987.1 BC032839.2 

    7 DOTS entries:

    DT.121275540  DT.444085  DT.121275562  DT.100775785  DT.121275545  DT.100775784  DT.95262075 

    24/101 AceView cDNA sequences (see all 101):

    BU167935 BQ946250 BU677511 AI373569 CA440164 AI301531 CA306219 AA866128 
    BQ893557 N63988 AI140291 AI338018 CA391802 CD366645 BU508131 AA854597 
    AW337373 BP356603 AA810945 AI458848 AI620542 BI494104 AI446658 BP364768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFIT2 expression in normal human tissues (normalized intensities)      IFIT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTTAAA
    IFIT2 Expression
    About this image


    IFIT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Respiratory System)    fully expand to see all 3 entries
             neutrophils   
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Bone (Muscoskeletal System)
             Human Calvarial Osteoblasts (HCO)   
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer

    See IFIT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFIT2

    SOURCE GeneReport for Unigene cluster: Hs.437609
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFIT2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit21 , 5 interferon-induced protein with tetratricopeptide repeats more1, 5 74.84(n)1
    63.77(a)1
      19 (29.73 cM)5
    159581  NM_008332.31  NP_032358.11 
     345506945 
    chicken
    (Gallus gallus)
    Aves --
    --
    39(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    27(a)
    26(a)
    possible ortholog
    possible ortholog
    GL343442.1(880721-891971)
    GL343442.1(893678-894883)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26g8.126
    si:dkey-26g8.116
    (see all 9)
    si:dkey-26g8.11
    (see all 9)
    30(a)
    30(a)
    (see all 9)
    possible ortholog
    many ↔ many
    (see all 9)
    12(18100446-18107181)
    12(18092678-18095207)


    ENSEMBL Gene Tree for IFIT2 (if available)
    TreeFam Gene Tree for IFIT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFIT2 gene
    IFIT12  IFIT1B2  IFIT32  IFIT52  
    4 SIMAP similar genes for IFIT2 using alignment to 3 protein entries:     IFIT2_HUMAN (see all proteins):
    IFIT3    IFIT1    IFIT1B    IFIT5

    IFIT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/207 SNPs in IFIT2 are shown (see all 207)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389795631,2
    C,Funtested191067047(+) TGAAAA/GAATGC 2 K R mis11Minor allele frequency- G:0.01EU 1212
    rs751659741,2
    C,F--91059831(+) TGGGAT/CATTAT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs763295711,2
    C,F--91059876(+) GCAGCA/CATGTA 1 -- us2k12Minor allele frequency- C:0.14CSA WA 120
    rs1403096591,2
    --91059994(+) ATTGAA/GAATAG 1 -- us2k10--------
    rs1873320941,2
    --91060028(+) AAGGGG/TGGTGG 1 -- us2k10--------
    rs1502145251,2
    --91060087(+) AAAAAA/TAAGTT 1 -- us2k10--------
    rs1917855281,2
    --91060113(+) CGACTA/GGGGTG 1 -- us2k10--------
    rs99433381,2
    C,F--91060563(+) acatgG/Atggaa 1 -- us2k13Minor allele frequency- A:0.17NA WA 6
    rs78992791,2
    C,F,H--91060601(+) tagccA/Gggcgt 1 -- us2k18Minor allele frequency- G:0.11NA WA CSA 18
    rs1836251651,2
    --91060614(+) TGGTGC/TGTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT2 (91061706 - 91069033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147040    OMIM disorders: --

    12 diseases for IFIT2:    About MalaCards
    ebola hemorrhagic fever    tick-borne encephalitis    japanese encephalitis    cytomegalovirus infection
    encephalitis    oral squamous cell carcinoma    hemorrhagic fever    west nile virus
    systemic lupus erythematosus    lupus erythematosus    squamous cell carcinoma    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for IFIT2:
    Ebola hemorrhagic fever

    IFIT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): IFIT2
    Human Genome Epidemiology (HuGE) Navigator: IFIT2 (1 document)

    Export disorders for IFIT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFIT2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with IFIT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (1988)
    2. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. (PubMed id 22825553)1, 2 Yang Z.... Liu Y. (2012)
    3. The interferon stimulated gene 54 promotes apoptosis. (PubMed id 21190939)1, 2 Stawowczyk M....Reich N.C. (2011)
    4. IFIT1 is an antiviral protein that recognizes 5'-trip hosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (2011)
    5. ISG56 is a negative-feedback regulator of virus-trigg ered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y....Shu H.B. (2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. (PubMed id 16973618)1, 2 Terenzi F....Sen G.C. (2006)
    8. Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)1, 3 Wathelet M.G....Szpirer C. (1988)
    9. Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. (PubMed id 2454816)1, 2 Wathelet M.G.... Huez G.A. (1988)
    10. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (PubMed id 3466167)1, 2 Levy D.... Darnell J.E. Jr. (1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3433 HGNC: 5409 AceView: IFIT2 Ensembl:ENSG00000119922 euGenes: HUgn3433
    ECgene: IFIT2 H-InvDB: IFIT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFIT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFIT2 gene:
    Search GeneIP for patents involving IFIT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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