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Aliases & Descriptions for IFIT2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| G10P2 2, 3, 5 | | GARG-39 1, 2 | | IFI-54 1, 2 | | IFI-54K 3 | | IFI54 2, 3, 5 | | IFIT-2 3 | | ISG-54K 1, 2 | | ISG54 2 | | OTTHUMP00000020058 2 | | cig42 1, 2 |
| | | Descriptions |
|---|
| ISG-54 K 3 | | Interferon, alpha-inducible protein (MW 54kD) 2 | | Interferon-induced 54 kDa protein 3 | | interferon-induced protein 54 2 | | interferon-induced protein with tetratricopeptide repeats 2 2 |
|
| | Search outside databases for aliases for IFIT2 genePrevious GC identifers: GC10U990034 GC10P090283 GC10P091192 GC10P090726 |
Summaries for IFIT2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for IFIT2 |
Genomic Location for IFIT2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFIT2 gene 
Entrez Gene cytogenetic band: 10q23-q25 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23-q25IFIT2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P091051:
(about GC identifiers)
Start:
|
91,051,686 bp from pter |
End:
|
91,059,013 bp from pter |
Size:
|
7,328 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for IFIT2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913 (See
protein sequence)Recommended Name: Interferon-induced protein with tetratricopeptide repeats 2 Size: 472 amino acids; 54632 Da
Secondary accessions: Q5T767Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001538.4
ENSEMBL proteins: ENSP00000360891 ENSP00000238977
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IFIT2: Assays for IFIT2: | Protein
Domains/ Families for IFIT2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P09913
ProtoNet protein and cluster: P09913 UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913Similarity: Belongs to the IFIT familySimilarity: Contains 6 TPR repeats | Gene Function for IFIT2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001547
Applied Biosystems Silencer® siRNAs for IFIT2
Sigma-Aldrich siRNA for IFIT2  Sigma-Aldrich shRNA for IFIT2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001547                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001547                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001547 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001547
UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913Induction: By interferonsGenatlas biochemistry entry for IFIT2:interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin 1,retinoic acid,viral infections...1 MGI phenotypic allele for Ifit2 (no phenotypes)
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
IEA | -- | About this table | Pathways & Interactions for IFIT2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for IFIT2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for IFIT2 
5/11 Interacting proteins for IFIT2 (ENSP000003608913 P099132) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for IFIT2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFIT2
|
Transcripts for IFIT2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001547
Sigma-Aldrich siRNA for IFIT2  Sigma-Aldrich shRNA for IFIT2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001547 REFSEQ mRNAs for IFIT2 gene: NM_001547.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001547               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001547                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001547                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001547  Additional cDNA sequence: AF026944.1 AK300431.1 AK312831.1 BC005987.1 BC032839.2 7 DOTS entries: DT.121275540 DT.444085 DT.121275562 DT.100775785 DT.121275545 DT.100775784 DT.95262075 24/101 AceView cDNA sequences (see all 101
):BU677511 BU167935 CD366645 AA810945 AI373569 BP356603 AA866128 CA306219 AW337373 AI458848 AI140291 AI620542 N63988 BI494104 AI446658 BQ946250 BQ893557 AI338018 CA391802 CA440164 BU508131 AI301531 AA854597 AV660046
highest scoring ESTs for IFIT2:AA131041 AA054658 AA056431 AA130252 AA131155 AA134105 AA143609 AA148160 AA484050 AA516150 Unigene Cluster for IFIT2: Interferon-induced protein with tetratricopeptide repeats 2 Hs.437609 [show with all ESTs]Unigene Representative Sequence: NM_001547
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000371826
ENST00000238977
|
Expression for IFIT2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFIT2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFIT2
1 / 2 / 3 7 probe-sets matching IFIT2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTTTTTAAA
SOURCE GeneReport for Unigene cluster: Hs.437609
Expression variation in blood from EXPOLDB for IFIT2 |
Orthologs for IFIT2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFIT2 gene from 4 species
About this table Species with no ortholog for IFIT2
ENSEMBL Gene Tree for IFIT2 | Paralogs for IFIT2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFIT2 gene
- IFIT12 IFIT32 IFIT52 IFIT1L2
|
SNPs/Variants for IFIT2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFIT2 (up to first 250kb)
|
Disorders & Mutations for IFIT2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 147040
|
Medical News for IFIT2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFIT2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for IFIT2 gene (see all 20
):- The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)2, 3, 4 Wathelet M.G....Huez G.A. (1988)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)2, 3 Wathelet M.G....Szpirer C. (1988)
- Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. (PubMed id 2454816)3, 4 Wathelet M.G.... Huez G.A. (1988)
- Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (PubMed id 3466167)3, 4 Levy D.... Darnell J.E. Jr. (1986)
- The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 3 Lafage M....Huez G. (1992)
- [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] (PubMed id 12708317)1, 3 Gavrilov B.G....Sverdlov E.D. (2003)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma. (PubMed id 18819931)3 Lai K.C....Lee T.C. (2008)
- Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. (PubMed id 16973618)3 Terenzi F....Sen G.C. (2006)
|
Search for IFIT2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFIT2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFIT2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFIT2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFIT2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFIT2:

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Incremental update: 13 Oct 2009
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