Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IFIT2 Gene

protein-coding   GIFtS: 62
GCID: GC10P091051

Interferon-Induced Protein With Tetratricopeptide Repeats...


(Previous symbols: IFI54, G10P2)
  See IFIT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 21 2     ISG-54 K2 3
G10P21 2 3 5     GARG-392
IFI541 2 3 5     IFI-542
Interferon-Induced 54 KDa Protein2 3     ISG-54K2
IFI-54K2 3     cig422
IFIT-22 3     Interferon, Alpha-Inducible Protein (MW 54kD)2
ISG542 3     Interferon-Induced Protein 542
P542 3     CIG-423

External Ids:    HGNC: 54091   Entrez Gene: 34332   Ensembl: ENSG000001199227   OMIM: 1470405   UniProtKB: P099133   

Export aliases for IFIT2 gene to outside databases

Previous GC identifers: GC10U990034 GC10P090283 GC10P091192 GC10P090726 GC10P084695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IFIT2 Gene:
IFIT2 (interferon-induced protein with tetratricopeptide repeats 2) is a protein-coding gene. Diseases associated with IFIT2 include ebola hemorrhagic fever. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT1.

UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
Function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation
of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and
non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system
such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation
(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is
required for antiviral activity. Can promote apoptosis

Gene Wiki entry for IFIT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFIT2 gene promoter:
         Spz1   IRF-1   Evi-1   C/EBPalpha   FOXL1   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT2 promoter sequence
   Search Chromatin IP Primers for IFIT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091051:  view genomic region     (about GC identifiers)

Start:
91,061,706 bp from pter      End:
91,069,033 bp from pter
Size:
7,328 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 2  
Size: 472 amino acids; 54632 Da
Subunit: Domain-swapped homodimer. Component of an interferon-dependent multiprotein complex, at least composed of
IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT3. Interacts with TMEM173/MITA and disrupts its interaction
with MAVS or TBK1. Interacts with EIF3E and EIF3C
1 PDB 3D structure from and Proteopedia for IFIT2:
4G1T (3D)    
Secondary accessions: Q5T767

Explore the universe of human proteins at neXtProt for IFIT2: NX_P09913

Explore proteomics data for IFIT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFIT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001538.4  
    ENSEMBL proteins: 
     ENSP00000360891  
    Reactome Protein details: P09913

    IFIT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IFIT2
    OriGene Protein Over-expression Lysate for IFIT2
    OriGene MassSpec for IFIT2
    OriGene Custom Protein Services for IFIT2
    GenScript Custom Purified and Recombinant Proteins Services for IFIT2
    Novus Biologicals IFIT2 Protein
    Novus Biologicals IFIT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFIT2

     
    Search eBioscience for Proteins for IFIT2 

    IFIT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IFIT2
    Novus Biologicals IFIT2 Antibodies
    Abcam antibodies for IFIT2
    Cloud-Clone Corp. Antibodies for IFIT2
    ThermoFisher Antibody for IFIT2
    LSBio Antibodies in human, mouse, rat for IFIT2

    IFIT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFIT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFIT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFIT2
    Cloud-Clone Corp. CLIAs for IFIT2
    Search eBioscience for ELISAs for IFIT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR024124 Interferon-induced_IFIT2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P09913

    ProtoNet protein and cluster: P09913

    UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913
    Domain: The C-terminal part folds into a super-helical structure and has an extensively positively-charged
    nucleotide-binding channel on its inner surface
    Similarity: Belongs to the IFIT family
    Similarity: Contains 9 TPR repeats


    Find genes that share domains with IFIT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT2_HUMAN, P09913
    Function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation
    of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and
    non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system
    such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation
    (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is
    required for antiviral activity. Can promote apoptosis
    Induction: By type I interferons, dsRNAs and viruses

         Genatlas biochemistry entry for IFIT2:
    interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin
    1,retinoic acid,viral infections...

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19416887
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with IFIT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IFIT2:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ifit2):
     behavior/neurological  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with IFIT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IFIT2: Ifit2tm1.1Ebsb Ifit2tm1.1Tac

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFIT2:
    hsa-mir-1 (MIRT023835), hsa-mir-124-3p (MIRT022752)

    Block miRNA regulation of human, mouse, rat IFIT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFIT2 (see all 9):
    hsa-miR-627 hsa-miR-589* hsa-let-7a-2* hsa-miR-133b hsa-miR-374c hsa-miR-133a hsa-miR-655 hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidIFIT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFIT2
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFIT2

    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT2 (see all 6)
    OriGene ORF clones in mouse, rat for IFIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT2 (NM_001547)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT2
    Addgene plasmids for IFIT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFIT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IFIT2_HUMAN, P09913: Cytoplasm. Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IFIT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IFIT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    2Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    3Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)


    Find genes that share SuperPaths with IFIT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IFIT2
        Immune response IFN alpha/beta signaling pathway

    1 BioSystems Pathway for IFIT2
        Type II interferon signaling (IFNG)

    1 Reactome Pathway for IFIT2
        Interferon alpha/beta signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFIT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFIT2 (P099131, 2, 3 ENSP000003608914) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148791, 2, 3, ENSP000003608764EBI-3507167,EBI-745127 MINT-66798 I2D: score=4 STRING: ENSP00000360876
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    IFIT1P099141, ENSP000003608694EBI-3507167,EBI-745117 STRING: ENSP00000360869
    KRT18P057833I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008637apoptotic mitochondrial changes TAS--
    GO:0009615response to virus IMP--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032091negative regulation of protein binding IDA19416887
    GO:0035457cellular response to interferon-alpha IEA--

    Find genes that share ontologies with IFIT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFIT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IFIT2 gene: 
    NM_001547.4  

    Unigene Cluster for IFIT2:

    Interferon-induced protein with tetratricopeptide repeats 2
    Hs.437609  [show with all ESTs]
    Unigene Representative Sequence: NM_001547
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371826(uc009xts.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFIT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFIT2 (see all 9):
    hsa-miR-627 hsa-miR-589* hsa-let-7a-2* hsa-miR-133b hsa-miR-374c hsa-miR-133a hsa-miR-655 hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidIFIT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFIT2
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT2
    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT2 (see all 6)
    OriGene ORF clones in mouse, rat for IFIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT2 (NM_001547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT2
    Addgene plasmids for IFIT2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFIT2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT2
      QuantiTect SYBR Green Assays in human, mouse, rat IFIT2
      QuantiFast Probe-based Assays in human, mouse, rat IFIT2

    Additional mRNA sequence: 

    AF026944.1 AK300431.1 AK312831.1 BC005987.1 BC032839.2 

    7 DOTS entries:

    DT.121275540  DT.444085  DT.121275562  DT.100775785  DT.121275545  DT.100775784  DT.95262075 

    Selected AceView cDNA sequences (see all 101):

    AI620542 AI458848 CA440164 AI338018 AA866128 BU508131 BQ893557 BP356603 
    AA810945 AA854597 CA391802 BI494104 CA306219 AI140291 AW337373 CD366645 
    BQ946250 AI373569 AI301531 BU677511 AI446658 N63988 BU167935 AV660046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IFIT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTTAAA
    IFIT2 Expression
    About this image


    IFIT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalon
             Floor plate-like cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    IFIT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFIT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437609
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT2: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFIT2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT2
    QuantiTect SYBR Green Assays in human, mouse, rat IFIT2
    QuantiFast Probe-based Assays in human, mouse, rat IFIT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit21 , 5 interferon-induced protein with tetratricopeptide repeats more1, 5 74.69(n)1
    63.77(a)1
      19 (29.73 cM)5
    159581  NM_008332.31  NP_032358.11 
     345506945 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    many ↔ many
    GL343442.1(880721-891971)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26g8.116
    ifit56
    (see all 8)
    si:dkey-26g8.11
    interferon-induced protein with tetratricopeptide ...
    (see all 8)
    30(a)
    30(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    12(18092678-18095207) ENSDARG00000007467
    12(18054322-18057848) ENSDARG00000090977


    ENSEMBL Gene Tree for IFIT2 (if available)
    TreeFam Gene Tree for IFIT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IFIT2 gene
    IFIT12  IFIT1B2  IFIT32  IFIT52  
    4 SIMAP similar genes for IFIT2 using alignment to 3 protein entries:     IFIT2_HUMAN (see all proteins):
    IFIT3    IFIT1    IFIT1B    IFIT5

    Find genes that share paralogs with IFIT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IFIT2 (see all 207)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389795631,2
    C,Funtested191067047(+) TGAAAA/GAATGC 2 K R mis11Minor allele frequency- G:0.01EU 1212
    rs751659741,2
    C,F--91059831(+) TGGGAT/CATTAT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs763295711,2
    C,F--91059876(+) GCAGCA/CATGTA 1 -- us2k12Minor allele frequency- C:0.14CSA WA 120
    rs1403096591,2
    --91059994(+) ATTGAA/GAATAG 1 -- us2k10--------
    rs1873320941,2
    --91060028(+) AAGGGG/TGGTGG 1 -- us2k10--------
    rs1502145251,2
    --91060087(+) AAAAAA/TAAGTT 1 -- us2k10--------
    rs1917855281,2
    --91060113(+) CGACTA/GGGGTG 1 -- us2k10--------
    rs99433381,2
    C,F--91060563(+) acatgG/Atggaa 1 -- us2k13Minor allele frequency- A:0.17NA WA 6
    rs78992791,2
    C,F,H--91060601(+) tagccA/Gggcgt 1 -- us2k18Minor allele frequency- G:0.11NA WA CSA 18
    rs1836251651,2
    --91060614(+) TGGTGC/TGTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT2 (91061706 - 91069033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFIT2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFIT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147040    OMIM disorders: --

    1 disease for IFIT2:    
    About MalaCards
    ebola hemorrhagic fever

    1 disease from the University of Copenhagen DISEASES database for IFIT2:
    Ebola hemorrhagic fever

    Find genes that share disorders with IFIT2           About GenesLikeMe

    Genetic Association Database (GAD): IFIT2
    Human Genome Epidemiology (HuGE) Navigator: IFIT2 (1 document)

    Export disorders for IFIT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IFIT2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with IFIT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (FEBS Lett. 1988)
    2. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. (PubMed id 22825553)1, 2 Yang Z.... Liu Y. (Cell Res. 2012)
    3. The interferon stimulated gene 54 promotes apoptosis. (PubMed id 21190939)1, 2 Stawowczyk M.... Reich N.C. (J. Biol. Chem. 2011)
    4. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    5. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y.... Shu H.B. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. (PubMed id 16973618)1, 2 Terenzi F.... Sen G.C. (J. Biol. Chem. 2006)
    8. Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)1, 3 Wathelet M.G....Szpirer C. (Somat. Cell Mol. Genet. 1988)
    9. Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. (PubMed id 2454816)1, 2 Wathelet M.G.... Huez G.A. (Eur. J. Biochem. 1988)
    10. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (PubMed id 3466167)1, 2 Levy D.... Darnell J.E. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3433 HGNC: 5409 AceView: IFIT2 Ensembl:ENSG00000119922 euGenes: HUgn3433
    ECgene: IFIT2 H-InvDB: IFIT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IFIT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IFIT2 gene:
    Search GeneIP for patents involving IFIT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFIT2  
     OriGene qPCR primer pairs and template standards for IFIT2   OriGene Protein Over-expression Lysate for IFIT2  
     OriGene MassSpec something-or-other for IFIT2   OriGene clones in human, mouse for IFIT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for IFIT2   OriGene Purified Protein for IFIT2  
     OriGene ORF clones in mouse, rat for IFIT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFIT2   OriGene Custom Protein Services for IFIT2  

     
     
     Block miRNA regulation of human, mouse, rat IFIT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFIT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT2 Predesigned siRNA for gene silencing in human, mouse, rat IFIT2
     QuantiFast Probe-based Assays in human, mouse, rat IFIT2 QuantiTect SYBR Green Assays in human, mouse, rat IFIT2
     PCR Arrays including human, mouse, rat IFIT2 Search Chromatin IP Primers for IFIT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT2  GeneGlobe Interaction Network for IFIT2
     Regulatory tfbs in IFIT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IFIT2 GenScript cDNA clones with any tag delivered in your preferred vector for IFIT2
     GenScript Custom Assay Services for IFIT2 GenScript Custom overexpressing Cell Line Services for IFIT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IFIT2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IFIT2 antibodies
     IFIT2 proteins
     IFIT2 lysates
     Antibodies for IFIT2
     See all of Abcam's Antibodies, Kits and Proteins for IFIT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IFIT2
     Antibodies for IFIT2
     ELISAs for IFIT2
     CLIAs for IFIT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT2
     SwitchGear 3'UTR luciferase reporter plasmids for IFIT2
     SwitchGear Promoter luciferase reporter plasmids for IFIT2
     ThermoFisher Antibody for IFIT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT2
     LSBio Antibodies in human, mouse, rat for IFIT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for IFIT2
      Search eBioscience for proteins for IFIT2
      Search eBioscience for elisas for IFIT2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFIT2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4