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IFIT1L Gene

protein-coding   GIFtS: 38

GC10P091128
interferon-induced protein with tetratricopeptide repeats 1-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp781M1841 2
OTTHUMP00000020061 2
bA149I23.6 1, 2
Descriptions
interferon-induced protein with tetratricopeptide repeats
1-like 2
External Ids
HGNC: 234421
Entrez Gene: 4399962
UniProtKB: Q5T7643
Ensembl: ENSG000002040107
Search outside databases for aliases for IFIT1L gene

Previous GC identifer: GC10U900469

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFIT1L gene  

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC chromosome: 10

IFIT1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091128:     (about GC identifiers)

Start:
91,127,793 bp from pter
End:
91,134,942 bp from pter
Size:
7,150 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFT1L_HUMAN, Q5T764 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1-like protein  
Size: 474 amino acids; 54993 Da

REFSEQ proteins: NP_001010987.1  

ENSEMBL proteins: 
ENSP00000360874 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for IFIT1L: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for IFIT1L

Assays for IFIT1L: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001440 TPR-1
 IPR011990 TPR-like_helical
 IPR013026 TPR_region
 IPR019734 TPR_repeat


   GeneDecks  IFIT1L for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q5T764

ProtoNet protein and cluster: Q5T764

UniProtKB/Swiss-Prot: IFT1L_HUMAN, Q5T764
Similarity: Belongs to the IFIT family
Similarity: Contains 8 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFIT1L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010987

              Applied Biosystems Silencer® siRNAs for IFIT1L

              Sigma-Aldrich siRNA for IFIT1L  
                     Sigma-Aldrich shRNA for IFIT1L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010987
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010987
                                 untagged cDNA clone in CMV expression vector: NM_001010987 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001010987

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005488 binding IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFIT1L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFIT1L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010987

              Sigma-Aldrich siRNA for IFIT1L  
                     Sigma-Aldrich shRNA for IFIT1L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001010987  

REFSEQ mRNAs for IFIT1L gene: 

NM_001010987.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001010987  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010987
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010987
                                 untagged cDNA clone in CMV expression vector: NM_001010987 

Additional cDNA sequence: 

BC137368.1 BC137369.1 BC150189.1 BX647300.1 

3 DOTS entries:

DT.307150  DT.121275376  DT.95159127 

8 AceView cDNA sequences:

BX280697 W86785 BX647300 W87286 BU662969 BU658774 R09292 R09187 

highest scoring ESTs for IFIT1L:

BU658774 BU662969 BX280697 BX647300 R09292 W86785 W87286 DN998805 NM_001010987 R09187 

Unigene Cluster for IFIT1L:

Interferon-induced protein with tetratricopeptide repeats 1-like
Hs.500491  [show with all ESTs]
Unigene Representative Sequence: BC150189


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000371809  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IFIT1L expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFIT1L

1 / 2 / 3

1 probe-set matching IFIT1L gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
44958_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 W86785 0.60 1.00 0.82 1
GeneDecks  IFIT1L for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGAAATCTCA

SOURCE GeneReport for Unigene cluster: Hs.500491
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IFIT1L gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
IFIT1L1   -- interferon-induced protein with tetratricopeptide repeats more 78.33(n)
67.61(a)
606817  XM_843249.1  XP_848342.1 
rat
(Rattus norvegicus)
Ifit11   -- interferon-induced protein with tetratricopeptide repeats more 71.71(n)
59.18(a)
56824  NM_020096.1  NP_064481.1 
mouse
(Mus musculus)
Ifit11   -- interferon-induced protein with tetratricopeptide repeats more 71.27(n)
58.53(a)
15957  NM_008331.2  NP_032357.2 
About this table        Species with no ortholog for IFIT1L

ENSEMBL Gene Tree for IFIT1L
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for IFIT1L gene
IFIT12  IFIT32  IFIT52  IFIT22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/57 NCBI SNPs in IFIT1L are shown (see all 57 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs3045021,2
A,C,F,H,O91127501(+) ATATAC/TGTTCC 1 -- ng51 tfbs315Minor allele frequency- T:0.26EU EA WA NA 1398
rs3045041,2
C,F,H,O91127806(-) GGTTCA/GTCCAC 1 -- ut5111Minor allele frequency- N:0.00NA EA EU WA 868
rs108879521,2
A,C,F,H91135034(+) TACTTC/TGGTAT 1 -- ng314Minor allele frequency- T:0.16EU EA WA 366
rs108879511,2
A,C,F,H91134889(+) tatttC/Tctgag 1 -- ut31 ese312Minor allele frequency- T:0.11EU EA WA 1248
rs112030991,2
A,C,F,H91126050(+) ATAGAC/TGTGGA 1 -- ng5111Minor allele frequency- T:0.22EU EA WA NA 980
rs3045031,2
A,C,F,O91127591(+) CCAGCA/GAGGGA 1 -- ng513Minor allele frequency- G:0.29NA 142
rs70727281,2
C,F,H91133613(+) TCGCCT/CGGATA 1 P/L mis18Minor allele frequency- C:0.03EU EA WA 834
rs70750041,2
C,F,H91135385(+) TCTACA/GGCATT 1 -- ng317Minor allele frequency- G:0.16EU EA WA NA 550
rs112031001,2
F,H91126523(+) ataccC/Taatta 1 -- ng514Minor allele frequency- T:0.06EU EA WA 408
--
rs112030971,2
F,H91125911(+) tacagC/Tgagac 1 -- ng514Minor allele frequency- T:0.02EU EA WA 420
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HapMap Linkage Disequilibrium images for IFIT1L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for IFIT1L gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 439996 HGNC: 23442 AceView: LOC439996 Ensembl:ENSG00000204010 euGenes: HUgn439996
ECgene: IFIT1L H-InvDB: IFIT1L
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFIT1L:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFIT1L-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for IFIT1L Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFIT1L Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for IFIT1L

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