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Aliases for IFIT1B Gene

Aliases for IFIT1B Gene

  • Interferon-Induced Protein With Tetratricopeptide Repeats 1B 2 3
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like Protein 3 4
  • IFIT1L 3 4
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like 2
  • BA149I23.6 3

External Ids for IFIT1B Gene

Previous HGNC Symbols for IFIT1B Gene

  • IFIT1L

Previous GeneCards Identifiers for IFIT1B Gene

  • GC10P091137
  • GC10P084771

Summaries for IFIT1B Gene

GeneCards Summary for IFIT1B Gene

IFIT1B (Interferon-Induced Protein With Tetratricopeptide Repeats 1B) is a Protein Coding gene. Among its related pathways are Hepatitis C and Influenza A. An important paralog of this gene is IFIT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT1B Gene

Genomics for IFIT1B Gene

Genomic Location for IFIT1B Gene

Start:
89,378,056 bp from pter
End:
89,385,205 bp from pter
Size:
7,150 bases
Orientation:
Plus strand

Genomic View for IFIT1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFIT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT1B Gene

No data available for Regulatory Elements for IFIT1B Gene

Proteins for IFIT1B Gene

  • Protein details for IFIT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T764-IFT1B_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 1B
    Protein Accession:
    Q5T764
    Secondary Accessions:
    • A7E245

    Protein attributes for IFIT1B Gene

    Size:
    474 amino acids
    Molecular mass:
    54993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFIT1B Gene

Proteomics data for IFIT1B Gene at MOPED

Post-translational modifications for IFIT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT1B Gene

Domains for IFIT1B Gene

Gene Families for IFIT1B Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFIT1B Gene

Suggested Antigen Peptide Sequences for IFIT1B Gene

Graphical View of Domain Structure for InterPro Entry

Q5T764

UniProtKB/Swiss-Prot:

IFT1B_HUMAN :
  • Q5T764
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with IFIT1B: view

Function for IFIT1B Gene

Gene Ontology (GO) - Molecular Function for IFIT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IFIT1B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFIT1B Gene

Localization for IFIT1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT1B Gene COMPARTMENTS Subcellular localization image for IFIT1B gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IFIT1B Gene

Pathways for IFIT1B Gene

SuperPathways for IFIT1B Gene

Superpath Contained pathways
1 Hepatitis C
2 Influenza A
genes like me logo Genes that share pathways with IFIT1B: view

Pathways by source for IFIT1B Gene

2 KEGG pathways for IFIT1B Gene

Interacting Proteins for IFIT1B Gene

Gene Ontology (GO) - Biological Process for IFIT1B Gene

None

Transcripts for IFIT1B Gene

mRNA/cDNA for IFIT1B Gene

(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFIT1B Gene

Interferon-induced protein with tetratricopeptide repeats 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IFIT1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT1B Gene

No ASD Table

Relevant External Links for IFIT1B Gene

GeneLoc Exon Structure for
IFIT1B
ECgene alternative splicing isoforms for
IFIT1B

Expression for IFIT1B Gene

mRNA expression in normal human tissues for IFIT1B Gene

mRNA differential expression in normal tissues according to GTEx for IFIT1B Gene

This gene is overexpressed in Whole Blood (48.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT1B Gene

SOURCE GeneReport for Unigene cluster for IFIT1B Gene Hs.500491

genes like me logo Genes that share expressions with IFIT1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IFIT1B Gene

Orthologs for IFIT1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT1B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 2010002M12Rik 36
  • 56 (a)
OneToMany
Gm14446 36
  • 58 (a)
OneToMany
Ifit1 35
  • 71.13 (n)
  • 58.75 (a)
Ifit1 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifit1 35
  • 71.63 (n)
  • 59.4 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 36
  • 32 (a)
ManyToMany
ifit2 36
  • 24 (a)
ManyToMany
ifit5 36
  • 31 (a)
ManyToMany
si:ch211-240h7.2 36
  • 23 (a)
ManyToMany
si:dkey-116m16.3 36
  • 23 (a)
ManyToMany
si:dkey-26g8.10 36
  • 31 (a)
ManyToMany
si:dkey-26g8.11 36
  • 32 (a)
ManyToMany
zgc:123282 36
  • 29 (a)
ManyToMany
Species with no ortholog for IFIT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT1B Gene

ENSEMBL:
Gene Tree for IFIT1B (if available)
TreeFam:
Gene Tree for IFIT1B (if available)

Paralogs for IFIT1B Gene

Paralogs for IFIT1B Gene

Selected SIMAP similar genes for IFIT1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFIT1B Gene

genes like me logo Genes that share paralogs with IFIT1B: view

Variants for IFIT1B Gene

Sequence variations from dbSNP and Humsavar for IFIT1B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs177565 -- 89,376,070(+) gtagt(C/G)ccagc upstream-variant-2KB
rs182506 -- 89,379,721(+) TAATA(A/T)AACGG intron-variant
rs188591 -- 89,378,573(+) TTCCA(C/T)GACCT intron-variant
rs192781 -- 89,376,183(+) actct(A/G)tctta upstream-variant-2KB
rs304492 -- 89,382,075(+) GTGAA(A/C)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFIT1B Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Relevant External Links for IFIT1B Gene

HapMap Linkage Disequilibrium report
IFIT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT1B Gene

Disorders for IFIT1B Gene

Relevant External Links for IFIT1B

Human Genome Epidemiology (HuGE) Navigator
IFIT1B
genes like me logo Genes that share disorders with IFIT1B: view

No data available for UniProtKB/Swiss-Prot for IFIT1B Gene

Publications for IFIT1B Gene

  1. Cloning and chromosomal location of human genes inducible by type I interferon. (PMID: 3175763) Wathelet M.G. … Szpirer C. (Somat. Cell Mol. Genet. 1988) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A. … Superti-Furga G. (Nat. Immunol. 2011) 3
  4. The broad-spectrum antiviral functions of IFIT and IFITM proteins. (PMID: 23237964) Diamond M.S. … Farzan M. (Nat. Rev. Immunol. 2013) 3
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4

Products for IFIT1B Gene

Sources for IFIT1B Gene

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