IFIT1B Gene
protein-coding GIFtS: 44
GCID: GC10P091137
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interferon-induced protein with tetratricopeptide repeats...(Previous name: interferon-induced protein with tetratricopeptide repeats...)
(Previous symbol: IFIT1L)
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Aliases
for IFIT1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon-Induced Protein With Tetratricopeptide Repeats 1B1 2 | | IFIT1L1 2 3 | | BA149I23.61 | | Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like Protein2 3 | | Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like1 |
Export aliases for IFIT1B gene to outside databasesPrevious GC identifer: GC10P084771 |
Summaries
for IFIT1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IFIT1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IFIT1B
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFIT1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23.31IFIT1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P091137: view genomic region
(about GC identifiers)
Start:
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91,137,813 bp from pter |
End:
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91,144,962 bp from pter |
Size:
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7,150 bases |
Orientation:
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plus strand |
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Proteins
for IFIT1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFT1B_HUMAN, Q5T764 (See
protein sequence)Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1B Size: 474 amino acids; 54993 Da
Secondary accessions: A7E245Explore the universe of human proteins at neXtProt for IFIT1B: NX_Q5T764
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T764
IFIT1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010987.1
ENSEMBL proteins: ENSP00000360874
Human Recombinant Protein Products:
IFIT1B Antibody Products:
Assay Products for IFIT1B: |
Protein
Domains /
Families
for IFIT1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFIT1B for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5T764ProtoNet protein and cluster: Q5T764 UniProtKB/Swiss-Prot: IFT1B_HUMAN, Q5T764Similarity: Belongs to the IFIT familySimilarity: Contains 8 TPR repeats |
Function
for IFIT1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFIT1B (NM_001010987) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFIT1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1B |
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Pathways & Interactions
for IFIT1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Hepatitis C | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for IFIT1B):
IFIT1B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFIT1B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for IFIT1B (Q5T7643 ENSP000003608744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for IFIT1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFIT1B
Search CenterWatch for drugs/clinical trials and news about IFIT1B / IFT1B
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Transcripts
for IFIT1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for IFIT1B gene: NM_001010987.2 Unigene Cluster for IFIT1B: Interferon-induced protein with tetratricopeptide repeats 1B Hs.500491 [show with all ESTs]Unigene Representative Sequence: BC1501891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371809(uc001kgh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFIT1B (NM_001010987) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFIT1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1B |
Additional cDNA sequence: BC137368.1 BC137369.1 BC150189.1 BX647300.1 3 DOTS entries: DT.307150 DT.121275376 DT.95159127 8 AceView cDNA sequences: BX280697 W86785 BX647300 BU662969 W87286 BU658774 R09292 R09187
GeneLoc Exon Structure
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Expression
for IFIT1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFIT1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAATCTCA
About this image
See IFIT1B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.500491
SABiosciences Custom PCR Arrays for IFIT1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFIT1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFIT1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1B |
Orthologs
for IFIT1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for IFIT1B gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for IFIT1B (if available)
TreeFam Gene Tree for IFIT1B (if available) |
Paralogs
for IFIT1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFIT1B gene
- IFIT12 IFIT32 IFIT52 IFIT22
4 SIMAP similar genes for IFIT1B using alignment to 1 protein entry: IFT1B_HUMAN:IFIT1 IFIT5 IFIT2 IFIT3
IFIT1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IFIT1B
PGOHUM00000238883
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Genomic Variants
for IFIT1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for IFIT1B (91137813 - 91144962 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFIT1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFIT1B |
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Disorders
/ Diseases
for IFIT1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFIT1B for disorders About GeneDecksing
2  diseases for IFIT1B: About MalaCardshepatitis c hepatitis
Human Genome Epidemiology (HuGE) Navigator: IFIT1B (1 document)
Export disorders for IFIT1B gene to outside databases
|
Publications
for IFIT1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFIT1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with IFIT1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)1 Wathelet M.G....Szpirer C. (1988)
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External Searches for IFIT1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IFIT1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing IFIT1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFIT1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFIT1B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IFIT1B gene:
Search GeneIP for patents involving IFIT1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFIT1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFIT1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFIT1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFIT1B | | | OriGene Protein Over-expression Lysate for IFIT1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFIT1B | | OriGene 3'-UTR Clone for IFIT1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFIT1B | | OriGene Custom Protein Services for IFIT1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFIT1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFIT1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFIT1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT1B |
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 |  |  |  | |
| | | | Search Tocris compounds for IFIT1B |
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 | | | IFIT1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1B |
|  |  |  | | | | Search ThermoFisher Antibodies for IFIT1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1B |
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