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Aliases for IFIT1B Gene

Aliases for IFIT1B Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 1B 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like Protein 3 4
  • IFIT1L 3 4
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like 2
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1B 2
  • BA149I23.6 3

External Ids for IFIT1B Gene

Previous HGNC Symbols for IFIT1B Gene

  • IFIT1L

Previous GeneCards Identifiers for IFIT1B Gene

  • GC10P091137
  • GC10P084771

Summaries for IFIT1B Gene

GeneCards Summary for IFIT1B Gene

IFIT1B (Interferon Induced Protein With Tetratricopeptide Repeats 1B) is a Protein Coding gene. Among its related pathways are Influenza A and Hepatitis C. An important paralog of this gene is IFIT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT1B Gene

Genomics for IFIT1B Gene

Regulatory Elements for IFIT1B Gene

Enhancers for IFIT1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFIT1B on UCSC Golden Path with GeneCards custom track

Genomic Location for IFIT1B Gene

Chromosome:
10
Start:
89,378,056 bp from pter
End:
89,385,205 bp from pter
Size:
7,150 bases
Orientation:
Plus strand

Genomic View for IFIT1B Gene

Genes around IFIT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT1B Gene

Proteins for IFIT1B Gene

  • Protein details for IFIT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T764-IFT1B_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 1B
    Protein Accession:
    Q5T764
    Secondary Accessions:
    • A7E245

    Protein attributes for IFIT1B Gene

    Size:
    474 amino acids
    Molecular mass:
    54993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFIT1B Gene

Proteomics data for IFIT1B Gene at MOPED

Post-translational modifications for IFIT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT1B Gene

Domains & Families for IFIT1B Gene

Gene Families for IFIT1B Gene

Protein Domains for IFIT1B Gene

Suggested Antigen Peptide Sequences for IFIT1B Gene

Graphical View of Domain Structure for InterPro Entry

Q5T764

UniProtKB/Swiss-Prot:

IFT1B_HUMAN :
  • Belongs to the IFIT family.
  • Contains 8 TPR repeats.
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with IFIT1B: view

Function for IFIT1B Gene

genes like me logo Genes that share phenotypes with IFIT1B: view

Animal Models for IFIT1B Gene

MGI Knock Outs for IFIT1B:

Animal Model Products

CRISPR Products

miRNA for IFIT1B Gene

miRTarBase miRNAs that target IFIT1B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFIT1B Gene

Localization for IFIT1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT1B Gene COMPARTMENTS Subcellular localization image for IFIT1B gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IFIT1B Gene

Pathways & Interactions for IFIT1B Gene

SuperPathways for IFIT1B Gene

Superpath Contained pathways
1 Hepatitis C
2 Influenza A
genes like me logo Genes that share pathways with IFIT1B: view

Pathways by source for IFIT1B Gene

2 KEGG pathways for IFIT1B Gene

Interacting Proteins for IFIT1B Gene

Gene Ontology (GO) - Biological Process for IFIT1B Gene

None

No data available for SIGNOR curated interactions for IFIT1B Gene

Drugs & Compounds for IFIT1B Gene

No Compound Related Data Available

Transcripts for IFIT1B Gene

mRNA/cDNA for IFIT1B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFIT1B Gene

Interferon-induced protein with tetratricopeptide repeats 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT1B Gene

No ASD Table

Relevant External Links for IFIT1B Gene

GeneLoc Exon Structure for
IFIT1B
ECgene alternative splicing isoforms for
IFIT1B

Expression for IFIT1B Gene

mRNA expression in normal human tissues for IFIT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT1B Gene

This gene is overexpressed in Whole Blood (x48.3).

Protein differential expression in normal tissues from HIPED for IFIT1B Gene

This gene is overexpressed in Plasma (39.3) and Serum (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT1B Gene



SOURCE GeneReport for Unigene cluster for IFIT1B Gene Hs.500491

genes like me logo Genes that share expression patterns with IFIT1B: view

Protein tissue co-expression partners for IFIT1B Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IFIT1B Gene

Orthologs for IFIT1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT1B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ifit1 35
  • 71.13 (n)
  • 58.75 (a)
Ifit1 16
2010002M12Rik 36
  • 56 (a)
OneToMany
Gm14446 36
  • 58 (a)
OneToMany
Ifit1 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifit1 35
  • 71.63 (n)
  • 59.4 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IFIT1B 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR759879.1 36
  • 32 (a)
ManyToMany
ifit2 36
  • 24 (a)
ManyToMany
ifit5 36
  • 31 (a)
ManyToMany
si:ch211-240h7.2 36
  • 23 (a)
ManyToMany
si:dkey-116m16.3 36
  • 23 (a)
ManyToMany
si:dkey-26g8.10 36
  • 31 (a)
ManyToMany
si:dkey-26g8.11 36
  • 32 (a)
ManyToMany
zgc:123282 36
  • 29 (a)
ManyToMany
Species with no ortholog for IFIT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT1B Gene

ENSEMBL:
Gene Tree for IFIT1B (if available)
TreeFam:
Gene Tree for IFIT1B (if available)

Paralogs for IFIT1B Gene

Paralogs for IFIT1B Gene

(4) SIMAP similar genes for IFIT1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFIT1B Gene

genes like me logo Genes that share paralogs with IFIT1B: view

Variants for IFIT1B Gene

Sequence variations from dbSNP and Humsavar for IFIT1B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7072728 - 89,383,876(+) TCGCC(C/T)GGATA reference, missense
rs177565 -- 89,376,070(+) gtagt(C/G)ccagc upstream-variant-2KB
rs182506 -- 89,379,721(+) TAATA(A/T)AACGG intron-variant
rs188591 -- 89,378,573(+) TTCCA(C/T)GACCT intron-variant
rs192781 -- 89,376,183(+) actct(A/G)tctta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFIT1B Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Variation tolerance for IFIT1B Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFIT1B Gene

Disorders for IFIT1B Gene

Relevant External Links for IFIT1B

Human Genome Epidemiology (HuGE) Navigator
IFIT1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFIT1B

No disorders were found for IFIT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFIT1B Gene

Publications for IFIT1B Gene

  1. The broad-spectrum antiviral functions of IFIT and IFITM proteins. (PMID: 23237964) Diamond M.S. … Farzan M. (Nat. Rev. Immunol. 2013) 3 67
  2. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A. … Superti-Furga G. (Nat. Immunol. 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Cloning and chromosomal location of human genes inducible by type I interferon. (PMID: 3175763) Wathelet M.G. … Szpirer C. (Somat. Cell Mol. Genet. 1988) 3

Products for IFIT1B Gene

Sources for IFIT1B Gene

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