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IFIT1B Gene

protein-coding   GIFtS: 46
GCID: GC10P091137

Interferon-Induced Protein With Tetratricopeptide Repeats...

(Previous name: interferon-induced protein with tetratricopeptide repeats...)
(Previous symbol: IFIT1L)
  Search for IFIT1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 1B1 2
IFIT1L1 2 3
Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like Protein2 3
Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like1
bA149I23.62

External Ids:    HGNC: 234421   Entrez Gene: 4399962   Ensembl: ENSG000002040107   UniProtKB: Q5T7643   

Export aliases for IFIT1B gene to outside databases

Previous GC identifer: GC10P084771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFIT1B Gene:
IFIT1B (interferon-induced protein with tetratricopeptide repeats 1B) is a protein-coding gene. An important paralog of this gene is IFIT1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IFIT1B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT1B promoter sequence
   Search Chromatin IP Primers for IFIT1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT1B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091137:  view genomic region     (about GC identifiers)

Start:
91,137,813 bp from pter      End:
91,144,962 bp from pter
Size:
7,150 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFT1B_HUMAN, Q5T764 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1B  
Size: 474 amino acids; 54993 Da
Secondary accessions: A7E245

Explore the universe of human proteins at neXtProt for IFIT1B: NX_Q5T764

Explore proteomics data for IFIT1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFIT1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010987.1  
    ENSEMBL proteins: 
     ENSP00000360874  

    IFIT1B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR024121 Interferon-induced_IFIT1
     IPR001440 TPR_1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q5T764

    ProtoNet protein and cluster: Q5T764

    UniProtKB/Swiss-Prot: IFT1B_HUMAN, Q5T764
    Similarity: Belongs to the IFIT family
    Similarity: Contains 8 TPR repeats


    Find genes that share domains with IFIT1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IFIT1B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT1B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFIT1B About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33
    2Hepatitis C
    Hepatitis C


    Find genes that share SuperPaths with IFIT1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for IFIT1B):
        Hepatitis C
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFIT1B
    Interactions:

        Search GeneGlobe Interaction Network for IFIT1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for IFIT1B (Q5T7643 ENSP000003608744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3CQ996133I2D: score=1 
    EIF3EENSP000002208494STRING: ENSP00000220849
    IFIT1ENSP000003608694STRING: ENSP00000360869
    IFIT3ENSP000003608764STRING: ENSP00000360876
    RUVBL1ENSP000003182974STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IEA--
    GO:0050688regulation of defense response to virus IEA--
    GO:0071357cellular response to type I interferon IEA--
    GO:0071360cellular response to exogenous dsRNA IEA--

    Find genes that share ontologies with IFIT1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFIT1B (IFT1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFIT1B gene: 
    NM_001010987.2  

    Unigene Cluster for IFIT1B:

    Interferon-induced protein with tetratricopeptide repeats 1B
    Hs.500491  [show with all ESTs]
    Unigene Representative Sequence: BC150189
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371809(uc001kgh.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat IFIT1B

    Additional mRNA sequence: 

    BC137368.1 BC137369.1 BC150189.1 BX647300.1 

    3 DOTS entries:

    DT.307150  DT.121275376  DT.95159127 

    8 AceView cDNA sequences:

    BX280697 W86785 BX647300 BU658774 BU662969 W87286 R09292 R09187 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFIT1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATCTCA
    IFIT1B Expression
    About this image

    IFIT1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFIT1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500491
        Custom PCR Arrays for IFIT1B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT1B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit11 interferon-induced protein with tetratricopeptide repeats more 71.13(n)
    58.75(a)
      15957  NM_008331.3  NP_032357.2 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    45(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    many ↔ many
    GL343442.1(880721-891971)
    zebrafish
    (Danio rerio)
    Actinopterygii CR759879.16
    si:dkey-26g8.116
    (see all 8)
    si:dkey-26g8.11
    (see all 8)
    32(a)
    32(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    5(64905516-64906895) ENSDARG00000088069
    12(18092678-18095207) ENSDARG00000007467


    ENSEMBL Gene Tree for IFIT1B (if available)
    TreeFam Gene Tree for IFIT1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFIT1B gene
    IFIT12  IFIT32  IFIT52  IFIT22  
    4 SIMAP similar genes for IFIT1B using alignment to 1 protein entry:     IFT1B_HUMAN:
    IFIT1    IFIT5    IFIT2    IFIT3

    Find genes that share paralogs with IFIT1B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IFIT1B
    PGOHUM00000238883


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFIT1B (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389721711,2
    C--91135825(+) CTGTAA/GTGCCA 1 -- us2k10--------
    rs112030971,2
    C,F,H--91135931(+) TACAGC/TGAGAC 1 -- us2k16Minor allele frequency- T:0.04NS EA CSA WA 540
    rs2006070191,2
    C--91135967(-) TTCTTC/TTNNNN 1 -- us2k10--------
    rs112030991,2
    C,F,A,H--91136070(+) ATAGAC/TGTGGA 1 -- us2k128Minor allele frequency- T:0.21NS EA NA WA 2916
    rs1812160941,2
    --91136097(+) ACATAG/TAGAGA 1 -- us2k10--------
    rs777150681,2
    C,F--91136162(+) CTCATT/GTCAAC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1860298021,2
    --91136193(+) TGTGAC/TGTTCC 1 -- us2k10--------
    rs70771871,2
    C,F,H--91136456(+) actggC/Acaata 1 -- us2k111Minor allele frequency- A:0.12NS EA NA WA 1388
    rs112031001,2
    C,F,H--91136543(+) ATACCC/TAATTA 1 -- us2k111Minor allele frequency- T:0.06NS EA NA CSA WA 774
    rs1437392191,2
    --91136677(+) GCTACA/TGTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT1B (91137813 - 91144962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFIT1B
    DNA2.0 Custom Variant and Variant Library Synthesis for IFIT1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with IFIT1B           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: IFIT1B (1 document)

    Export disorders for IFIT1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFIT1B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IFIT1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)1 Wathelet M.G....Szpirer C. (Somat. Cell Mol. Genet. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 439996 HGNC: 23442 AceView: LOC439996 Ensembl:ENSG00000204010 euGenes: HUgn439996
    ECgene: IFIT1B Kegg: 439996 H-InvDB: IFIT1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFIT1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IFIT1B gene:
    Search GeneIP for patents involving IFIT1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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