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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFIT1 Gene

protein-coding   GIFtS: 56
GCID: GC10P091142

interferon-induced protein with tetratricopeptide repeats...


(Previous symbols: G10P1, IFI56, IFNAI1)
 Explore 19 diseases affiliated with
IFIT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IFIT1    

Aliases
for IFIT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 11 2     P562 3
G10P11 2 3 5     GARG-161
IFI561 2 3 5     C562
IFNAI11 2 3 5     IFI-562
Interferon-Induced 56 KDa Protein2 3     RNM5612
IFI-56K2 3     Interferon, Alpha-Inducible Protein (MW 56kD)2
IFIT-12 3     Interferon-Inducible MRNA 5612
ISG562 3     

External Ids:    HGNC: 54071   Entrez Gene: 34342   Ensembl: ENSG000001857457   OMIM: 1476905   UniProtKB: P099143   

Export aliases for IFIT1 gene to outside databases

Previous GC identifers: GC10P090033 GC10P090374 GC10P091283 GC10P090816 GC10P084786


Summaries
for IFIT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IFIT1:
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon
treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene
is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on
chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. (provided by
RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of
viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate
group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self
mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved
several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing
host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several
viruses including human papilloma and hepatitis C viruses

Gene Wiki entry for IFIT1


Genomic Views
for IFIT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFIT1 gene promoter:
         ISGF-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Gfi-1   GATA-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFIT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFIT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091142:  view genomic region     (about GC identifiers)

Start:
 91,152,303 bp from pter      End:
 91,163,745 bp from pter
Size:
 11,443 bases      Orientation:
 plus strand

Proteins
for IFIT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1  
Size: 478 amino acids; 55360 Da
Subunit: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3.
Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with
IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction
with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and
this interaction blocks E1 helicase activity and viral replication
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for IFIT1:
4HOU (3D)    
Secondary accessions: Q5T7J1 Q96QM5

Explore the universe of human proteins at neXtProt for IFIT1: NX_P09914

Post-translational modifications:

  • Phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09914

    • IFIT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257856.1  NP_001257857.1  NP_001257858.1  NP_001257859.1  NP_001539.3  

    ENSEMBL proteins: 
     ENSP00000360869   ENSP00000441968  
    Reactome Protein details: P09914
    Human Recombinant Protein Products: 
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    Novus Biologicals IFIT1 Proteins
    Novus Biologicals IFIT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IFIT1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19008854
    GO:0005829cytosol TAS--


    IFIT1 for ontologies           About GeneDecksing



    IFIT1 Antibody Products: 
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    Novus Biologicals IFIT1 Antibodies
    Abcam antibodies for IFIT1 
    Uscn Antibodies for IFIT1
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    Assay Products for IFIT1: 
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    Browse OriGene Fluorogenic Cell Assay Kits
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    Uscn ELISAs and CLIAs for IFIT1

    Protein Domains /
    Families
    for IFIT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IFIT1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011990 TPR-like_helical
     IPR024121 Interferon-induced_IFIT1
     IPR001440 TPR-1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P09914

    ProtoNet protein and cluster: P09914

    UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
    Domain: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds
    unique additional helices that form an RNA binding cleft (By similarity)
    Similarity: Belongs to the IFIT family
    Similarity: Contains 10 TPR repeats


    Function
    for IFIT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
    Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
    5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of
    viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate
    group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self
    mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved
    several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing
    host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several
    viruses including human papilloma and hepatitis C viruses
    Induction: By type I interferons, dsRNAs and viruses

         Genatlas biochemistry entry for IFIT1:
    interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral infection...

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IFIT1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFIT1
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    SwitchGear 3'UTR luciferase reporter plasmid: IFIT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFIT1 (see all 7)
    OriGene shRNA RFP: IFIT1
    OriGene siRNA: IFIT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFIT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IFIT1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFIT1 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFIT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA--
    GO:0005515protein binding IPI19416887


    IFIT1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ifit1tm1(KOMP)Vlcg for IFIT1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ifit1):
     immune system  mortality/aging 

    IFIT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IFIT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    2Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    3Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		ISG15 antiviral mechanism0.49
    		Antiviral mechanism by IFN-stimulated genes0.49
    4NF-kappaB Signaling
    		NF-kappaB Signaling1.00
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IFIT1
        NF-kappaB Signaling

    5/8        Reactome Pathways for IFIT1 (see all 8)
        Antiviral mechanism by IFN-stimulated genes
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes
    Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18


    1         Kegg Pathway  (Kegg details for IFIT1):
        Hepatitis C


    IFIT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for IFIT1 (P099141, 2, 3 ENSP000003608694) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148791, 3, ENSP000003608764EBI-745117,EBI-745127 I2D: score=4 STRING: ENSP00000360876
    ISG15P051613, ENSP000003686994I2D: score=1 STRING: ENSP00000368699
    EIF3EP602283, ENSP000002208494I2D: score=4 STRING: ENSP00000220849
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    IFIT2P099131, ENSP000003608914EBI-745117,EBI-3507167 STRING: ENSP00000360891
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IMP--
    GO:0019060intracellular transport of viral proteins in host cell IDA19008854
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032091negative regulation of protein binding IDA19416887
    GO:0045070positive regulation of viral genome replication IDA19416887


    IFIT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IFIT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFIT1
    Search CenterWatch for drugs/clinical trials and news about IFIT1 

    Transcripts
    for IFIT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IFIT1 gene (5 alternative transcripts): 
    NM_001270927.1  NM_001270928.1  NM_001270929.1  NM_001270930.1  NM_001548.4  

    Unigene Cluster for IFIT1:

    Interferon-induced protein with tetratricopeptide repeats 1
    Hs.20315  [show with all ESTs]
    Unigene Representative Sequence: NM_001270930
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371804(uc001kgi.3 uc009xtt.3) ENST00000546318(uc001kgj.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFIT1
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    SwitchGear 3'UTR luciferase reporter plasmid: IFIT1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFIT1 (see all 7)
    OriGene shRNA RFP: IFIT1
    OriGene siRNA: IFIT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFIT1
    Clone
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    GenScript: all cDNA clones in your preferred vector: IFIT1 (NM_001548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFIT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT1

    Additional cDNA sequence: 

    AK308688.1 AK314588.1 BC007091.1 BT006667.1 X03557.1 

    13 DOTS entries:

    DT.100820538  DT.95169821  DT.121275570  DT.91781773  DT.117949  DT.95169820  DT.100820540  DT.121275499 
    DT.100028746  DT.100820537  DT.40189878  DT.40189933  DT.95159127 

    24/294 AceView cDNA sequences (see all 294):

    CR621649 BE047761 AA418970 CA423585 BX282126 W89172 BU626426 AA418854 
    BM806425 CK905606 BM984600 BQ929397 CR591778 BM667480 CA429724 AA255765 
    CB128868 BQ775914 AA489640 AW193161 CA417752 BU622654 BQ067882 AI866538 

    GeneLoc Exon Structure


    Expression
    for IFIT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGAAAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IFIT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IFIT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFIT1

    SOURCE GeneReport for Unigene cluster: Hs.20315
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFIT1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1

    Orthologs
    for IFIT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IFIT56
    		 Uncharacterized protein
    		 42(a)
    		 1 → many
    		 6(20444489-20445958)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 30(a)
    29(a)
    		 possible ortholog
    possible ortholog
    		 GL343442.1(893678-894883)
    GL343442.1(887475-889386)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5673841 interferon-induced protein with tetratricopeptide repeats more 46.5(n)
    35.49(a)    		   567384  XM_690678.3  XP_695770.2 


    ENSEMBL Gene Tree for IFIT1 (if available)
    TreeFam Gene Tree for IFIT1 (if available) 

    Paralogs
    for IFIT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFIT1 gene
    IFIT1B2  IFIT32  IFIT52  IFIT22  
    4 SIMAP similar genes for IFIT1 using alignment to 2 protein entries:     IFIT1_HUMAN (see all proteins):
    IFIT1B    IFIT5    IFIT2    IFIT3

    IFIT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IFIT1
    PGOHUM00000248562


    Genomic Variants
    for IFIT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/313 NCBI SNPs in IFIT1 are shown (see all 313)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1892378001,2
    		--91150366(+) CTGTAA/CACACA 5 -- us2k10--------
    rs1380446981,2
    		--91150367(+) TGTAA-/ACACACA 5 -- us2k10--------
    rs771089661,2
    		F,--91150379(+) CACACA/GCGCGC 5 -- us2k12Minor allele frequency- G:0.06NA EA 240
    rs1930740191,2
    		--91150381(+) CACACA/GCGCGC 5 -- us2k10--------
    rs1854062491,2
    		--91150383(+) CACGCA/GCGCGA 5 -- us2k10--------
    rs1393531951,2
    		--91150408(+) CTTAAC/TGCTGT 5 -- us2k10--------
    rs1473689321,2
    		C,--91150451(+) AAAGA-/GGACAC 5 -- us2k10--------
    rs57868681,2
    		C--91150453(+) AAGAGG/-ACACT 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1500249511,2
    		--91150506(+) GTAGAA/GCCAAG 5 -- us2k10--------
    rs1898880581,2
    		--91150535(+) GCAATA/GGCAAG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT1 (91152303 - 91163745 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IFIT1
         1 CNV: 47891

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    Disorders / Diseases
    for IFIT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IFIT1 for disorders           About GeneDecksing

    OMIM gene information: 147690    OMIM disorders: --

    19 diseases for IFIT1:    About MalaCards
    brown-sequard syndrome    spinal stenosis    tick-borne encephalitis    spinal cord disease
    ebola hemorrhagic fever    epidural abscess    discitis    spondylosis
    hemorrhagic fever    exostosis    quadriplegia    radiculopathy
    encephalitis    hepatitis c    alzheimer's disease    ovarian cancer
    gastric cancer    hepatitis    herpes simplex

    Human Genome Epidemiology (HuGE) Navigator: IFIT1 (2 documents)

    Export disorders for IFIT1 gene to outside databases

    Publications
    for IFIT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFIT1 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with IFIT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (1988)
    2. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 3, 9 Lafage M....Huez G. (1992)
    3. A novel interaction between interferon-inducible prot ein p56 and ribosomal protein L15 in gastric cancer cells. (PubMed id 21612406)1, 2 Hsu Y.A....Chen B.H. (2011)
    4. The ISG56/IFIT1 gene family. (PubMed id 20950130)1, 2 Fensterl V. and Sen G.C. (2011)
    5. ISG56 and IFITM1 proteins inhibit hepatitis C virus r eplication. (PubMed id 21976647)1, 2 Raychoudhuri A....Ray R.B. (2011)
    6. IFIT1 is an antiviral protein that recognizes 5'-trip hosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (2011)
    7. ISG56 is a negative-feedback regulator of virus-trigg ered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y....Shu H.B. (2009)
    8. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. (PubMed id 19008854)1, 2 Terenzi F....Sen G.C. (2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for IFIT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing IFIT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3434 HGNC: 5407 AceView: IFIT1 Ensembl:ENSG00000185745 euGenes: HUgn3434
    ECgene: IFIT1 Kegg: 3434 H-InvDB: IFIT1

    Other Databases showing IFIT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IFIT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFIT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IFIT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IFIT1 gene:
    Search GeneIP for patents involving IFIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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