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Aliases & Descriptions for IFIT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| G10P1 2, 3, 5 | | GARG-16 1, 2 | | IFI-56 2 | | IFI-56K 3 | | IFI56 2, 3, 5 | | IFIT-1 3 | | IFNAI1 2, 3, 5 | | ISG56 2 | | OTTHUMP00000020062 2 | | RNM561 2 |
| | | Descriptions |
|---|
| Interferon, alpha-inducible protein (MW 56kD) 2 | | Interferon-induced 56 kDa protein 3 | | interferon-induced protein 56 2 | | interferon-induced protein with tetratricopeptide repeats 1 2 |
|
| | Search outside databases for aliases for IFIT1 genePrevious GC identifers: GC10P090033 GC10P090374 GC10P091283 GC10P090816 |
Summaries for IFIT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for IFIT1 |
Genomic Location for IFIT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFIT1 gene 
Entrez Gene cytogenetic band: 10q25-q26 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q25-q26IFIT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P091142:
(about GC identifiers)
Start:
|
91,142,302 bp from pter |
End:
|
91,153,725 bp from pter |
Size:
|
11,424 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for IFIT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914 (See
protein sequence)Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1 Size: 478 amino acids; 55360 Da
Secondary accessions: Q96QM5REFSEQ proteins: NP_001539.3
ENSEMBL proteins: ENSP00000360869
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: IFIT1 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for IFIT1: Assays for IFIT1: | Protein
Domains/ Families for IFIT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P09914
ProtoNet protein and cluster: P09914 UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914Similarity: Belongs to the IFIT familySimilarity: Contains 10 TPR repeats | Gene Function for IFIT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001548
Applied Biosystems Silencer® siRNAs for IFIT1
Sigma-Aldrich siRNA for IFIT1  Sigma-Aldrich shRNA for IFIT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001548                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001548                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001001887 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001548
UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914Induction: By interferonsGenatlas biochemistry entry for IFIT1:interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral infection...1 MGI phenotypic allele for Ifit1 (no phenotypes)
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
IEA | -- | About this table | Pathways & Interactions for IFIT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for IFIT1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for IFIT1 
5/20 Interacting proteins for IFIT1 (ENSP000003608693) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for IFIT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFIT1
|
Transcripts for IFIT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001548
Sigma-Aldrich siRNA for IFIT1  Sigma-Aldrich shRNA for IFIT1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001548 REFSEQ mRNAs for IFIT1 gene: NM_001548.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001548               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001548                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001548                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001001887  Additional cDNA sequence: AK092813.1 AK095515.1 AK308688.1 AK314588.1 BC007091.1 BT006667.1 CR591778.1 CR593386.1 CR601585.1 CR617896.1 CR621649.1 CR623965.1 X03557.1 11 DOTS entries: DT.100820538 DT.95169821 DT.121275570 DT.91781773 DT.117949 DT.95169820 DT.100820540 DT.100028746 DT.121275499 DT.100820537 DT.95159127 24/294 AceView cDNA sequences (see all 294
):CA306581 CB128868 AA255765 CA429724 CA417752 BE047761 AA454955 AA774201 CR601585 BM806425 CR591778 T87833 AI418532 BM463689 AA489743 AA418970 W89171 BX362644 CA748917 C20944 BE885288 T72026 AW193161 AA494116
highest scoring ESTs for IFIT1:AA074989 AA173630 AA249243 AA418854 AI132949 AL575223 AW167059 AW381055 BE047761 BE172900 Unigene Cluster for IFIT1: Interferon-induced protein with tetratricopeptide repeats 1 Hs.20315 [show with all ESTs]Unigene Representative Sequence: AK095515
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000371804
|
Expression for IFIT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFIT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFIT1
1 / 2 / 3 4 probe-sets matching IFIT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAAGAAAGAG
SOURCE GeneReport for Unigene cluster: Hs.20315
Expression variation in blood from EXPOLDB for IFIT1 |
Orthologs for IFIT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFIT1 gene from 5 species
About this table Species with no ortholog for IFIT1
ENSEMBL Gene Tree for IFIT1 | Paralogs for IFIT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFIT1 gene
- IFIT32 IFIT52 IFIT1L2 IFIT22
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for IFIT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFIT1 (up to first 250kb)
|
Disorders & Mutations for IFIT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 147690
1 PharmGKB disease relationship for IFIT1 geneAbout this table
|
Medical News for IFIT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFIT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for IFIT1 gene (see all 23
):- The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)2, 3, 4 Wathelet M.G....Huez G.A. (1988)
- The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 2, 3 Lafage M....Huez G. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- New inducers revealed by the promoter sequence analysis of two interferon-activated human genes. (PubMed id 3121313)3, 4 Wathelet M.G.... Huez G.A. (1987)
- Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons. (PubMed id 3753936)3, 4 Wathelet M.... Content J. (1986)
- Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA. (PubMed id 6186990)3, 4 Chebath J.... Revel M. (1983)
- [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] (PubMed id 12708317)1, 3 Gavrilov B.G....Sverdlov E.D. (2003)
- Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. (PubMed id 19008854)3 Terenzi F....Sen G.C. (2008)
- Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. (PubMed id 16973618)3 Terenzi F....Sen G.C. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
|
Search for IFIT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFIT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFIT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFIT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFIT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFIT1:

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Incremental update: 13 Oct 2009
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