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Aliases for IFIT1 Gene

Aliases for IFIT1 Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 1 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1 2 3
  • Interferon-Induced 56 KDa Protein 3 4
  • IFI-56K 3 4
  • IFNAI1 3 4
  • IFIT-1 3 4
  • G10P1 3 4
  • IFI56 3 4
  • ISG56 3 4
  • P56 3 4
  • Interferon, Alpha-Inducible Protein (MW 56kD) 3
  • Interferon-Inducible MRNA 561 3
  • IFI-56 3
  • RNM561 3
  • C56 3

External Ids for IFIT1 Gene

Previous HGNC Symbols for IFIT1 Gene

  • G10P1
  • IFI56
  • IFNAI1

Previous GeneCards Identifiers for IFIT1 Gene

  • GC10P090033
  • GC10P090374
  • GC10P091283
  • GC10P090816
  • GC10P091142
  • GC10P084786

Summaries for IFIT1 Gene

Entrez Gene Summary for IFIT1 Gene

  • This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

GeneCards Summary for IFIT1 Gene

IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) is a Protein Coding gene. Diseases associated with IFIT1 include Hepatitis C. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT1B.

UniProtKB/Swiss-Prot for IFIT1 Gene

  • Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Gene Wiki entry for IFIT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT1 Gene

Genomics for IFIT1 Gene

Regulatory Elements for IFIT1 Gene

Enhancers for IFIT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F089294 1.3 FANTOM5 Ensembl ENCODE 18.4 -96.1 -96128 3.2 RAD51 CEBPB PRDM1 IFIT3 IFIT2 IFIT5 IFIT1 IFIT1B FAS ENSG00000232110 LOC105378419
GH10F089368 0.8 Ensembl ENCODE 15.9 -23.1 -23146 1.2 CTCF ZNF654 SMC3 TRIM22 RAD21 IFIT5 IFIT1 IFIT3 ENSG00000232110 IFIT2 LIPA IFIT1B IFIT6P
GH10F089260 1.3 FANTOM5 Ensembl ENCODE 13.4 -130.0 -130023 5.0 ARID4B SIN3A RAD21 ZEB1 RFX5 GATA2 SCRT2 ZNF143 RCOR1 FOS IFIT3 IFIT2 IFIT1 IFIT1B SLC16A12-AS1 IFIT5 ENSG00000232110 GC10P089210
GH10F089363 0.5 Ensembl 11.5 -28.4 -28446 0.6 PKNOX1 NFYB SPI1 IFIT5 IFIT3 IFIT1 ENSG00000232110 LIPA IFIT6P IFIT1B
GH10F089364 0.2 ENCODE 11.5 -29.4 -29418 0.1 TBL1XR1 TAL1 ARID1B NCOR1 GATA2 SMARCA4 KLF16 KDM1A TRIM24 IFIT3 IFIT1 ENSG00000232110 IFIT5 LIPA IFIT6P IFIT1B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFIT1 on UCSC Golden Path with GeneCards custom track

Promoters for IFIT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001762685 954 3400 TBP ZNF76 ARID4B SIN3A BRCA1 RAD21 RFX5 SCRT2 ETV6 JUNB

Genomic Location for IFIT1 Gene

Chromosome:
10
Start:
89,392,546 bp from pter
End:
89,406,487 bp from pter
Size:
13,942 bases
Orientation:
Plus strand

Genomic View for IFIT1 Gene

Genes around IFIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT1 Gene

Proteins for IFIT1 Gene

  • Protein details for IFIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09914-IFIT1_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 1
    Protein Accession:
    P09914
    Secondary Accessions:
    • B3KS50
    • D3DR31
    • Q5T7J1
    • Q96QM5

    Protein attributes for IFIT1 Gene

    Size:
    478 amino acids
    Molecular mass:
    55360 Da
    Quaternary structure:
    • Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication.

    Three dimensional structures from OCA and Proteopedia for IFIT1 Gene

    Alternative splice isoforms for IFIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFIT1 Gene

Post-translational modifications for IFIT1 Gene

Other Protein References for IFIT1 Gene

No data available for DME Specific Peptides for IFIT1 Gene

Domains & Families for IFIT1 Gene

Gene Families for IFIT1 Gene

Protein Domains for IFIT1 Gene

Graphical View of Domain Structure for InterPro Entry

P09914

UniProtKB/Swiss-Prot:

IFIT1_HUMAN :
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft.
  • Belongs to the IFIT family.
  • Contains 10 TPR repeats.
Domain:
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft.
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 10 TPR repeats.
genes like me logo Genes that share domains with IFIT1: view

Function for IFIT1 Gene

Molecular function for IFIT1 Gene

GENATLAS Biochemistry:
interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral infection...
UniProtKB/Swiss-Prot Function:
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
UniProtKB/Swiss-Prot Induction:
By type I interferons, dsRNAs and viruses.

Gene Ontology (GO) - Molecular Function for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 21642987
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IFIT1: view
genes like me logo Genes that share phenotypes with IFIT1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFIT1 Gene

Localization for IFIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT1 Gene COMPARTMENTS Subcellular localization image for IFIT1 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19008854
GO:0005829 cytosol TAS --
GO:0043657 host cell IEA --
genes like me logo Genes that share ontologies with IFIT1: view

Pathways & Interactions for IFIT1 Gene

genes like me logo Genes that share pathways with IFIT1: view

Gene Ontology (GO) - Biological Process for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus IEA,IMP 21642987
GO:0016032 viral process IEA --
GO:0019060 intracellular transport of viral protein in host cell IDA 19008854
GO:0032091 negative regulation of protein binding IDA 19416887
GO:0045070 positive regulation of viral genome replication IDA 19416887
genes like me logo Genes that share ontologies with IFIT1: view

No data available for SIGNOR curated interactions for IFIT1 Gene

Transcripts for IFIT1 Gene

Unigene Clusters for IFIT1 Gene

Interferon-induced protein with tetratricopeptide repeats 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT1 Gene

No ASD Table

Relevant External Links for IFIT1 Gene

GeneLoc Exon Structure for
IFIT1
ECgene alternative splicing isoforms for
IFIT1

Expression for IFIT1 Gene

mRNA expression in normal human tissues for IFIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT1 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.7).

Protein differential expression in normal tissues from HIPED for IFIT1 Gene

This gene is overexpressed in Spleen (16.2), Bone (9.0), and Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFIT1 Gene



Protein tissue co-expression partners for IFIT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFIT1 Gene:

IFIT1

SOURCE GeneReport for Unigene cluster for IFIT1 Gene:

Hs.20315
genes like me logo Genes that share expression patterns with IFIT1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IFIT1 Gene

Orthologs for IFIT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFIT1 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia IFIT1 34 35
  • 80.76 (n)
dog
(Canis familiaris)
Mammalia IFIT1 34 35
  • 80.75 (n)
rat
(Rattus norvegicus)
Mammalia Ifit1lb 34
  • 70.59 (n)
mouse
(Mus musculus)
Mammalia Gm14446 34
  • 69.82 (n)
Ifit1bl2 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifit5 34
  • 50.71 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26g8.12 34
  • 47.07 (n)
si:dkey-26g8.11 35
  • 32 (a)
ManyToMany
ifit5 35
  • 31 (a)
ManyToMany
si:dkey-26g8.10 35
  • 31 (a)
ManyToMany
CR759879.1 35
  • 30 (a)
ManyToMany
zgc:123282 35
  • 28 (a)
ManyToMany
ifit2 35
  • 24 (a)
ManyToMany
si:ch211-240h7.2 35
  • 24 (a)
ManyToMany
si:dkey-116m16.3 35
  • 24 (a)
ManyToMany
Species where no ortholog for IFIT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT1 Gene

ENSEMBL:
Gene Tree for IFIT1 (if available)
TreeFam:
Gene Tree for IFIT1 (if available)

Paralogs for IFIT1 Gene

Paralogs for IFIT1 Gene

(4) SIMAP similar genes for IFIT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IFIT1 Gene

genes like me logo Genes that share paralogs with IFIT1: view

Variants for IFIT1 Gene

Sequence variations from dbSNP and Humsavar for IFIT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1062926 -- 89,403,422(+) ATTTC(C/T)ACTAT reference, missense
rs10788642 -- 89,396,596(+) ATTCA(C/T)GAGAG intron-variant
rs10887954 -- 89,406,049(+) TATGG(C/T)ACATC utr-variant-3-prime
rs10887955 -- 89,406,798(+) GTCAG(C/T)GAGAC downstream-variant-500B
rs111332096 -- 89,391,770(+) TCATC(C/T)GCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFIT1 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV loss 18971310
nsv819719 CNV gain 19587683

Variation tolerance for IFIT1 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFIT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT1 Gene

Disorders for IFIT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFIT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
- elite association - COSMIC cancer census association via MalaCards
Search IFIT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFIT1

Genetic Association Database (GAD)
IFIT1
Human Genome Epidemiology (HuGE) Navigator
IFIT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFIT1
genes like me logo Genes that share disorders with IFIT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFIT1 Gene

Publications for IFIT1 Gene

  1. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PMID: 1377167) Lafage M. … Huez G. (Genomics 1992) 2 3 22 64
  2. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PMID: 3360121) Wathelet M.G. … Huez G.A. (FEBS Lett. 1988) 2 3 4 64
  3. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PMID: 23334420) Abbas Y.M. … Nagar B. (Nature 2013) 3 4 64
  4. The ISG56/IFIT1 gene family. (PMID: 20950130) Fensterl V. … Sen G.C. (J. Interferon Cytokine Res. 2011) 3 4 64
  5. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A. … Superti-Furga G. (Nat. Immunol. 2011) 3 4 64

Products for IFIT1 Gene

Sources for IFIT1 Gene

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