Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IFIT1 Gene

protein-coding   GIFtS: 59
GCID: GC10P091142

Interferon-Induced Protein With Tetratricopeptide Repeats...


(Previous symbols: G10P1, IFI56, IFNAI1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 11 2     ISG562 3
G10P11 2 3 5     P562 3
IFI561 2 3 5     C562
IFNAI11 2 3 5     IFI-562
Interferon-Induced 56 KDa Protein2 3     RNM5612
IFI-56K2 3     Interferon, Alpha-Inducible Protein (MW 56kD)2
IFIT-12 3     Interferon-Inducible MRNA 5612

External Ids:    HGNC: 54071   Entrez Gene: 34342   Ensembl: ENSG000001857457   OMIM: 1476905   UniProtKB: P099143   

Export aliases for IFIT1 gene to outside databases

Previous GC identifers: GC10P090033 GC10P090374 GC10P091283 GC10P090816 GC10P084786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IFIT1 Gene:
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon
treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This
gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for
this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been
observed. (provided by RefSeq, Aug 2012)

GeneCards Summary for IFIT1 Gene:
IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) is a protein-coding gene. Diseases associated with IFIT1 include brown-sequard syndrome, and discitis. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT1B.

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting
expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear
a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish
between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a
non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding
their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching
mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses

Gene Wiki entry for IFIT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFIT1 gene promoter:
         ISGF-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Gfi-1   GATA-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT1 promoter sequence
   Search Chromatin IP Primers for IFIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091142:  view genomic region     (about GC identifiers)

Start:
91,152,303 bp from pter      End:
91,163,745 bp from pter
Size:
11,443 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1  
Size: 478 amino acids; 55360 Da
Subunit: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3.
Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with
IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its
interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types
11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication
1 PDB 3D structure from and Proteopedia for IFIT1:
4HOU (3D)    
Secondary accessions: Q5T7J1 Q96QM5

Explore the universe of human proteins at neXtProt for IFIT1: NX_P09914

Explore proteomics data for IFIT1 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • ISGylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257856.1  NP_001257857.1  NP_001257858.1  NP_001257859.1  NP_001539.3  

    ENSEMBL proteins: 
     ENSP00000360869   ENSP00000441968  
    Reactome Protein details: P09914

    IFIT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IFIT1
    OriGene Protein Over-expression Lysate for IFIT1
    OriGene MassSpec for IFIT1
    OriGene Custom Protein Services for IFIT1
    GenScript Custom Purified and Recombinant Proteins Services for IFIT1
    Novus Biologicals IFIT1 Proteins
    Novus Biologicals IFIT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFIT1

    IFIT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for IFIT1 
    OriGene Antibodies for IFIT1
    OriGene Custom Antibody Services for IFIT1
    Novus Biologicals IFIT1 Antibodies
    Abcam antibodies for IFIT1
    Cloud-Clone Corp. Antibodies for IFIT1
    ThermoFisher Antibody for IFIT1
    LSBio Antibodies in human, mouse, rat for IFIT1

    IFIT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFIT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFIT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFIT1
    Cloud-Clone Corp. CLIAs for IFIT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR024121 Interferon-induced_IFIT1
     IPR001440 TPR_1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P09914

    ProtoNet protein and cluster: P09914

    UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
    Domain: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which
    scaffolds unique additional helices that form an RNA binding cleft (By similarity)
    Similarity: Belongs to the IFIT family
    Similarity: Contains 10 TPR repeats


    IFIT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT1_HUMAN, P09914
    Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
    5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting
    expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear
    a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish
    between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a
    non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding
    their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching
    mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses
    Induction: By type I interferons, dsRNAs and viruses

         Genatlas biochemistry entry for IFIT1:
    interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral
    infection...

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA--
    GO:0005515protein binding IPI16189514
         
    IFIT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ifit1):
     immune system  mortality/aging 

    IFIT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ifit1tm1(KOMP)Vlcg for IFIT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFIT1:
    hsa-mir-1 (MIRT024022), hsa-mir-146a-5p (MIRT021232), hsa-mir-375 (MIRT020013)

    Block miRNA regulation of human, mouse, rat IFIT1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFIT1
    SwitchGear 3'UTR luciferase reporter plasmidIFIT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFIT1
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFIT1

    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT1 (see all 6)
    OriGene ORF clones in mouse, rat for IFIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT1 (NM_001548)
    Sino Biological Human cDNA Clone for IFIT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFIT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IFIT1_HUMAN, P09914: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    IFIT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IFIT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    3Influenza A
    Herpes simplex infection0.33
    4NF-kappaB Signaling
    NF-kappaB Signaling
    5Hepatitis C
    Hepatitis C

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IFIT1
        NF-kappaB Signaling


    2 Reactome Pathways for IFIT1
        Interferon alpha/beta signaling
    ISG15 antiviral mechanism


    2 Kegg Pathways  (Kegg details for IFIT1):
        Hepatitis C
    Herpes simplex infection


    IFIT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFIT1 (P099141, 2, 3 ENSP000003608694) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148791, 3, ENSP000003608764EBI-745117,EBI-745127 I2D: score=4 STRING: ENSP00000360876
    ISG15P051613, ENSP000003686994I2D: score=1 STRING: ENSP00000368699
    EIF3EP602283, ENSP000002208494I2D: score=4 STRING: ENSP00000220849
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    IFIT2P099131, ENSP000003608914EBI-745117,EBI-3507167 STRING: ENSP00000360891
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IMP--
    GO:0019060intracellular transport of viral protein in host cell IDA19008854
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032091negative regulation of protein binding IDA19416887
    GO:0045070positive regulation of viral genome replication IDA19416887

    IFIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFIT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IFIT1 gene (5 alternative transcripts): 
    NM_001270927.1  NM_001270928.1  NM_001270929.1  NM_001270930.1  NM_001548.4  

    Unigene Cluster for IFIT1:

    Interferon-induced protein with tetratricopeptide repeats 1
    Hs.20315  [show with all ESTs]
    Unigene Representative Sequence: NM_001270930
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371804(uc001kgi.3 uc009xtt.3) ENST00000546318(uc001kgj.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFIT1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFIT1
    SwitchGear 3'UTR luciferase reporter plasmidIFIT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFIT1
    Predesigned siRNA for gene silencing in human, mouse, rat IFIT1
    Clone
    Products:
         
    OriGene clones in human, mouse for IFIT1 (see all 6)
    OriGene ORF clones in mouse, rat for IFIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFIT1 (NM_001548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFIT1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT1
      QuantiTect SYBR Green Assays in human, mouse, rat IFIT1
      QuantiFast Probe-based Assays in human, mouse, rat IFIT1

    Additional mRNA sequence: 

    AK308688.1 AK314588.1 BC007091.1 BT006667.1 X03557.1 

    13 DOTS entries:

    DT.100820538  DT.95169821  DT.121275570  DT.91781773  DT.117949  DT.95169820  DT.100820540  DT.121275499 
    DT.100028746  DT.100820537  DT.40189878  DT.40189933  DT.95159127 

    Selected AceView cDNA sequences (see all 294):

    BQ772458 AA494116 BM984600 BQ575083 AA255765 CA748917 CA429724 AA454954 
    AI884887 NM_001001887 BQ010471 CR621649 AI688417 W89172 CA423585 AA454955 
    T72026 AV652920 BM971259 AA418854 CK905606 BU622654 BE047761 CR601585 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IFIT1 expression in normal human tissues (normalized intensities)      IFIT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGAAAGAG
    IFIT1 Expression
    About this image


    IFIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    IFIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20315
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFIT1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFIT1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT1
    QuantiTect SYBR Green Assays in human, mouse, rat IFIT1
    QuantiFast Probe-based Assays in human, mouse, rat IFIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit15
    Gm144461
    interferon-induced protein with tetratricopeptide repeats more5
    predicted gene 144461
    69.82(n)1
    57.8(a)1
      19 (29.78 cM)5
    6673731  NM_001110517.11  NP_001103987.11 
     346408715 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    42(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    many ↔ many
    GL343442.1(880721-891971)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ifit51 interferon-induced protein with tetratricopeptide repeats more 50.71(n)
    39.05(a)
      100216220  NM_001142188.1  NP_001135660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26g8.121 si:dkey-26g8.12 47.07(n)
    36.49(a)
      567384  XM_005169460.1  XP_005169517.1 


    ENSEMBL Gene Tree for IFIT1 (if available)
    TreeFam Gene Tree for IFIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IFIT1 gene
    IFIT1B2  IFIT32  IFIT52  IFIT22  
    4 SIMAP similar genes for IFIT1 using alignment to 2 protein entries:     IFIT1_HUMAN (see all proteins):
    IFIT1B    IFIT5    IFIT2    IFIT3

    IFIT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IFIT1
    PGOHUM00000248562


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IFIT1 (see all 358)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892378001,2
    C--91150366(+) CTGTAA/CACACA 5 -- us2k10--------
    rs1380446981,2
    C--91150367(+) TGTAA-/ACACACA 5 -- us2k10--------
    rs771089661,2
    C,F--91150379(+) CACACA/G/TCGCGC 5 -- us2k12NA EA 240
    rs1930740191,2
    --91150381(+) CACACA/GCGCGC 5 -- us2k10--------
    rs1854062491,2
    C--91150383(+) CACGCA/GCGCGA 5 -- us2k10--------
    rs1393531951,2
    --91150408(+) CTTAAC/TGCTGT 5 -- us2k10--------
    rs57868681,2
    C--91150452(+) AAAGAG/-GACAC 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1500249511,2
    --91150506(+) GTAGAA/GCCAAG 5 -- us2k10--------
    rs1898880581,2
    --91150535(+) GCAATA/GGCAAG 5 -- us2k10--------
    rs1917566661,2
    --91150550(+) ACTTTA/TTGTTC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT1 (91152303 - 91163745 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147690    OMIM disorders: --

    Selected diseases for IFIT1 (see all 21):    About MalaCards
    brown-sequard syndrome    discitis    epidural abscess    ebola hemorrhagic fever
    tick-borne encephalitis    exostosis    spondylosis    spinal cord disease
    radiculopathy    spinal stenosis    quadriplegia    hepatitis c virus
    hemorrhagic fever    encephalitis    papilloma    herpes simplex
    hepatitis c    hepatitis    ovarian cancer    alzheimer's disease


    IFIT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): IFIT1
    Human Genome Epidemiology (HuGE) Navigator: IFIT1 (2 documents)

    Export disorders for IFIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IFIT1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with IFIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (FEBS Lett. 1988)
    2. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 3, 9 Lafage M....Huez G. (Genomics 1992)
    3. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PubMed id 23334420)1, 2 Abbas Y.M.... Nagar B. (Nature 2013)
    4. A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. (PubMed id 21612406)1, 2 Hsu Y.A.... Chen B.H. (DNA Cell Biol. 2011)
    5. The ISG56/IFIT1 gene family. (PubMed id 20950130)1, 2 Fensterl V. and Sen G.C. (J. Interferon Cytokine Res. 2011)
    6. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. (PubMed id 21976647)1, 2 Raychoudhuri A.... Ray R.B. (J. Virol. 2011)
    7. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y.... Shu H.B. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. (PubMed id 19008854)1, 2 Terenzi F.... Sen G.C. (EMBO J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3434 HGNC: 5407 AceView: IFIT1 Ensembl:ENSG00000185745 euGenes: HUgn3434
    ECgene: IFIT1 Kegg: 3434 H-InvDB: IFIT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IFIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IFIT1 gene:
    Search GeneIP for patents involving IFIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IFIT1   OriGene RNAi products in human, mouse, rat for IFIT1  
     OriGene qPCR primer pairs and template standards for IFIT1   OriGene Protein Over-expression Lysate for IFIT1  
     OriGene MassSpec something-or-other for IFIT1   OriGene clones in human, mouse for IFIT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IFIT1   OriGene Purified Protein for IFIT1  
     OriGene ORF clones in mouse, rat for IFIT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFIT1   OriGene Custom Protein Services for IFIT1  

     
     
     Block miRNA regulation of human, mouse, rat IFIT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFIT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFIT1 Predesigned siRNA for gene silencing in human, mouse, rat IFIT1
     QuantiFast Probe-based Assays in human, mouse, rat IFIT1 QuantiTect SYBR Green Assays in human, mouse, rat IFIT1
     PCR Arrays including human, mouse, rat IFIT1 Search Chromatin IP Primers for IFIT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFIT1  GeneGlobe Interaction Network for IFIT1
     Regulatory tfbs in IFIT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IFIT1 GenScript cDNA clones with any tag delivered in your preferred vector for IFIT1
     GenScript Custom Assay Services for IFIT1 GenScript Custom overexpressing Cell Line Services for IFIT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for IFIT1 

     Search Tocris compounds for IFIT1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IFIT1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IFIT1 antibodies
     IFIT1 proteins
     IFIT1 lysates
     Antibodies for IFIT1
     See all of Abcam's Antibodies, Kits and Proteins for IFIT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IFIT1
     Antibodies for IFIT1
     ELISAs for IFIT1
     CLIAs for IFIT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IFIT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1
     SwitchGear 3'UTR luciferase reporter plasmids for IFIT1
     SwitchGear Promoter luciferase reporter plasmids for IFIT1
     ThermoFisher Antibody for IFIT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFIT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFIT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFIT1
     LSBio Antibodies in human, mouse, rat for IFIT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFIT1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4