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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFIT1 Gene

protein-coding   GIFtS: 59
GCID: GC10P091142

Interferon-Induced Protein With Tetratricopeptide Repeats...


(Previous symbols: G10P1, IFI56, IFNAI1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon-Induced Protein With Tetratricopeptide Repeats 11 2     ISG562 3
G10P11 2 3 5     P562 3
IFI561 2 3 5     C562
IFNAI11 2 3 5     IFI-562
Interferon-Induced 56 KDa Protein2 3     RNM5612
IFI-56K2 3     Interferon, Alpha-Inducible Protein (MW 56kD)2
IFIT-12 3     Interferon-Inducible MRNA 5612

External Ids:    HGNC: 54071   Entrez Gene: 34342   Ensembl: ENSG000001857457   OMIM: 1476905   UniProtKB: P099143   

Export aliases for IFIT1 gene to outside databases

Previous GC identifers: GC10P090033 GC10P090374 GC10P091283 GC10P090816 GC10P084786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFIT1 Gene:
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon
treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This
gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for
this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been
observed. (provided by RefSeq, Aug 2012)

GeneCards Summary for IFIT1 Gene: 
IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) is a protein-coding gene. Diseases associated with IFIT1 include brown-sequard syndrome, and discitis, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include protein binding and RNA binding. An important paralog of this gene is IFIT1B.

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting
expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear
a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish
between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a
non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding
their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching
mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses

Gene Wiki entry for IFIT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFIT1 gene promoter:
         ISGF-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Gfi-1   GATA-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFIT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFIT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

IFIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091142:  view genomic region     (about GC identifiers)

Start:
91,152,303 bp from pter      End:
91,163,745 bp from pter
Size:
11,443 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1  
Size: 478 amino acids; 55360 Da
Subunit: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3.
Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with
IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its
interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types
11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for IFIT1:
4HOU (3D)    
Secondary accessions: Q5T7J1 Q96QM5

Explore the universe of human proteins at neXtProt for IFIT1: NX_P09914

Explore proteomics data for IFIT1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09914

  • IFIT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFIT1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001257856.1  NP_001257857.1  NP_001257858.1  NP_001257859.1  NP_001539.3  

    ENSEMBL proteins: 
     ENSP00000360869   ENSP00000441968  
    Reactome Protein details: P09914
    Human Recombinant Protein Products for IFIT1: 
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    Novus Biologicals IFIT1 Proteins
    Novus Biologicals IFIT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFIT1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19008854
    GO:0005829cytosol TAS--

    IFIT1 for ontologies           About GeneDecksing



    IFIT1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for IFIT1 

    Assay Products for IFIT1: 
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    Cloud-Clone Corp. ELISAs for IFIT1 
    Cloud-Clone Corp. CLIAs for IFIT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR024121 Interferon-induced_IFIT1
     IPR001440 TPR-1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P09914

    ProtoNet protein and cluster: P09914

    UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
    Domain: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which
    scaffolds unique additional helices that form an RNA binding cleft (By similarity)
    Similarity: Belongs to the IFIT family
    Similarity: Contains 10 TPR repeats


    IFIT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFIT1_HUMAN, P09914
    Function: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a
    5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting
    expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear
    a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish
    between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a
    non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding
    their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching
    mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses
    Induction: By type I interferons, dsRNAs and viruses

         Genatlas biochemistry entry for IFIT1:
    interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral
    infection...

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA--
    GO:0005515protein binding IPI16189514
         
    IFIT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ifit1):
     immune system  mortality/aging 

    IFIT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ifit1tm1(KOMP)Vlcg for IFIT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFIT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFIT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFIT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFIT1 

    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of IFIT1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFIT1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45
    4Influenza A
    Herpes simplex infection0.33
    5Hepatitis C
    Hepatitis C

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IFIT1
        NF-kappaB Signaling

    5/6        Reactome Pathways for IFIT1 (see all 6)
        Antiviral mechanism by IFN-stimulated genes
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    ISG15 antiviral mechanism


    2         Kegg Pathways  (Kegg details for IFIT1):
        Hepatitis C
    Herpes simplex infection


    IFIT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for IFIT1 (P099141, 2, 3 ENSP000003608694) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFIT3O148791, 3, ENSP000003608764EBI-745117,EBI-745127 I2D: score=4 STRING: ENSP00000360876
    ISG15P051613, ENSP000003686994I2D: score=1 STRING: ENSP00000368699
    EIF3EP602283, ENSP000002208494I2D: score=4 STRING: ENSP00000220849
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    IFIT2P099131, ENSP000003608914EBI-745117,EBI-3507167 STRING: ENSP00000360891
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IMP--
    GO:0019060intracellular transport of viral proteins in host cell IDA19008854
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032091negative regulation of protein binding IDA19416887
    GO:0045070positive regulation of viral genome replication IDA19416887

    IFIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFIT1

    Search CenterWatch for drugs/clinical trials and news about IFIT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFIT1 gene (5 alternative transcripts): 
    NM_001270927.1  NM_001270928.1  NM_001270929.1  NM_001270930.1  NM_001548.4  

    Unigene Cluster for IFIT1:

    Interferon-induced protein with tetratricopeptide repeats 1
    Hs.20315  [show with all ESTs]
    Unigene Representative Sequence: NM_001270930
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371804(uc001kgi.3 uc009xtt.3) ENST00000546318(uc001kgj.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFIT1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFIT1
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    Additional mRNA sequence: 

    AK308688.1 AK314588.1 BC007091.1 BT006667.1 X03557.1 

    13 DOTS entries:

    DT.100820538  DT.95169821  DT.121275570  DT.91781773  DT.117949  DT.95169820  DT.100820540  DT.121275499 
    DT.100028746  DT.100820537  DT.40189878  DT.40189933  DT.95159127 

    24/294 AceView cDNA sequences (see all 294):

    AI866538 BM806425 BQ067882 BM984600 AA418854 BX362644 BE047761 AL574038 
    CA429724 CR617896 AA489743 BU622654 AA418970 CA417752 C20944 BQ010471 
    AA454955 CR593386 BQ772458 W89172 CA748917 T87833 BU626426 AA255765 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFIT1 expression in normal human tissues (normalized intensities)      IFIT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGAAAGAG
    IFIT1 Expression
    About this image


    IFIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             leukocytes   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             sensory organ/eye/cornea   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Knee Normal Human Articular chondrocytes (knNHAC)   
             skeleton/cranium   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Human fetal bone marrow-derived mesenchymal stromal cells
             skeleton/cranium   

    See IFIT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFIT1

    SOURCE GeneReport for Unigene cluster: Hs.20315
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFIT1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFIT1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifit15
    Gm144461
    interferon-induced protein with tetratricopeptide repeats more5
    predicted gene 144461
    69.98(n)1
    58.06(a)1
      19 (29.78 cM)5
    6673731  NM_001110517.11  NP_001103987.11 
     346408715 
    chicken
    (Gallus gallus)
    Aves --
    --
    42(a)
    1 → many
    6(18900981-18904128)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    30(a)
    30(a)
    possible ortholog
    possible ortholog
    GL343442.1(893678-894883)
    GL343442.1(880721-891971)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5673841 interferon-induced protein with tetratricopeptide repeats more 46.5(n)
    35.49(a)
      567384  XM_690678.3  XP_695770.2 


    ENSEMBL Gene Tree for IFIT1 (if available)
    TreeFam Gene Tree for IFIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFIT1 gene
    IFIT1B2  IFIT32  IFIT52  IFIT22  
    4 SIMAP similar genes for IFIT1 using alignment to 2 protein entries:     IFIT1_HUMAN (see all proteins):
    IFIT1B    IFIT5    IFIT2    IFIT3

    IFIT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IFIT1
    PGOHUM00000248562


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/358 SNPs in IFIT1 are shown (see all 358)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892378001,2
    C--91150366(+) CTGTAA/CACACA 5 -- us2k10--------
    rs1380446981,2
    C--91150367(+) TGTAA-/ACACACA 5 -- us2k10--------
    rs771089661,2
    C,F--91150379(+) CACACA/G/TCGCGC 5 -- us2k12NA EA 240
    rs1930740191,2
    --91150381(+) CACACA/GCGCGC 5 -- us2k10--------
    rs1854062491,2
    C--91150383(+) CACGCA/GCGCGA 5 -- us2k10--------
    rs1393531951,2
    --91150408(+) CTTAAC/TGCTGT 5 -- us2k10--------
    rs57868681,2
    C--91150452(+) AAAGAG/-GACAC 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1500249511,2
    --91150506(+) GTAGAA/GCCAAG 5 -- us2k10--------
    rs1898880581,2
    --91150535(+) GCAATA/GGCAAG 5 -- us2k10--------
    rs1917566661,2
    --91150550(+) ACTTTA/TTGTTC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFIT1 (91152303 - 91163745 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFIT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34085CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147690    OMIM disorders: --

    20 diseases for IFIT1:    About MalaCards
    brown-sequard syndrome    discitis    epidural abscess    ebola hemorrhagic fever
    tick-borne encephalitis    spondylosis    radiculopathy    spinal stenosis
    spinal cord disease    exostosis    quadriplegia    hemorrhagic fever
    encephalitis    papilloma    herpes simplex    hepatitis c
    gastric cancer    alzheimer's disease    hepatitis    ovarian cancer


    IFIT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): IFIT1
    Human Genome Epidemiology (HuGE) Navigator: IFIT1 (2 documents)

    Export disorders for IFIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFIT1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with IFIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (1988)
    2. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 3, 9 Lafage M....Huez G. (1992)
    3. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (PubMed id 23334420)1, 2 Abbas Y.M.... Nagar B. (2013)
    4. A novel interaction between interferon-inducible prot ein p56 and ribosomal protein L15 in gastric cancer cells. (PubMed id 21612406)1, 2 Hsu Y.A....Chen B.H. (2011)
    5. The ISG56/IFIT1 gene family. (PubMed id 20950130)1, 2 Fensterl V. and Sen G.C. (2011)
    6. ISG56 and IFITM1 proteins inhibit hepatitis C virus r eplication. (PubMed id 21976647)1, 2 Raychoudhuri A....Ray R.B. (2011)
    7. IFIT1 is an antiviral protein that recognizes 5'-trip hosphate RNA. (PubMed id 21642987)1, 2 Pichlmair A....Superti-Furga G. (2011)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    9. ISG56 is a negative-feedback regulator of virus-trigg ered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y....Shu H.B. (2009)
    10. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. (PubMed id 19008854)1, 2 Terenzi F....Sen G.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3434 HGNC: 5407 AceView: IFIT1 Ensembl:ENSG00000185745 euGenes: HUgn3434
    ECgene: IFIT1 Kegg: 3434 H-InvDB: IFIT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFIT1 gene:
    Search GeneIP for patents involving IFIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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