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IFIT1 Gene

protein-coding   GIFtS: 56

GC10P091142
interferon-induced protein with tetratricopeptide repeats 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: G10P1, IFI56, IFNAI1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
G10P1 2, 3, 5
GARG-16 1, 2
IFI-56 2
IFI-56K 3
IFI56 2, 3, 5
IFIT-1 3
IFNAI1 2, 3, 5
ISG56 2
OTTHUMP00000020062 2
RNM561 2
Descriptions
Interferon, alpha-inducible protein (MW 56kD) 2
Interferon-induced 56 kDa protein 3
interferon-induced protein 56 2
interferon-induced protein with tetratricopeptide repeats 1 2
External Ids
HGNC: 54071
Entrez Gene: 34342
UniProtKB: P099143
Ensembl: ENSG000001857457
Search outside databases for aliases for IFIT1 gene

Previous GC identifers: GC10P090033 GC10P090374 GC10P091283 GC10P090816

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for IFIT1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFIT1 gene  

Entrez Gene cytogenetic band: 10q25-q26   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q25-q26

IFIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P091142:     (about GC identifiers)

Start:
91,142,302 bp from pter
End:
91,153,725 bp from pter
Size:
11,424 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914 (See protein sequence)
Recommended Name: Interferon-induced protein with tetratricopeptide repeats 1  
Size: 478 amino acids; 55360 Da
Secondary accessions: Q96QM5

REFSEQ proteins: NP_001539.3  

ENSEMBL proteins: 
ENSP00000360869 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (IFIT1)
Human Recombinant Proteins from Abnova (IFIT1)
              OriGene Purified Recombinant Human Protein: IFIT1 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm NAS3753936
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Antibodies for IFIT1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (IFIT1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (IFIT1)
Novus Biologicals Antibodies for IFIT1

Assays for IFIT1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001440 TPR-1
 IPR011990 TPR-like_helical
 IPR013026 TPR_region
 IPR019734 TPR_repeat


   GeneDecks  IFIT1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P09914

ProtoNet protein and cluster: P09914

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
Similarity: Belongs to the IFIT family
Similarity: Contains 10 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFIT1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001548

              Applied Biosystems Silencer® siRNAs for IFIT1

              Sigma-Aldrich siRNA for IFIT1  
                     Sigma-Aldrich shRNA for IFIT1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IFIT1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001548
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001548
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001001887 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001548

UniProtKB/Swiss-Prot: IFIT1_HUMAN, P09914
Induction: By interferons

Genatlas biochemistry entry for IFIT1:
interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic
acid,viral infection...
1 MGI phenotypic allele for Ifit1 (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005488 binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  IFIT1  (Your Favorite Gene powered by Ingenuity) 
 Interferon Signaling

   GeneDecks  IFIT1 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  IFIT1 


5/20 Interacting proteins for IFIT1 (ENSP000003608693) via UniProtKB, MINT, and/or STRING (see all 20 )
InteractantInteraction Details
GeneCardExternal ID(s)
IRF3ENSP000003101273STRING (score=.991)
IRF7ENSP000003294113STRING (score=.952)
IKBKEENSP000003560873STRING (score=.931)
TANKENSP000002590753STRING (score=.922)
TBK1ENSP000003299673STRING (score=.903)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFIT1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFIT1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001548

              Sigma-Aldrich siRNA for IFIT1  
                     Sigma-Aldrich shRNA for IFIT1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001548  

REFSEQ mRNAs for IFIT1 gene: 

NM_001548.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001548  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001548
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001548
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001001887 

Additional cDNA sequence: 

AK092813.1 AK095515.1 AK308688.1 AK314588.1 BC007091.1 BT006667.1 CR591778.1 CR593386.1 
CR601585.1 CR617896.1 CR621649.1 CR623965.1 X03557.1 

11 DOTS entries:

DT.100820538  DT.95169821  DT.121275570  DT.91781773  DT.117949  DT.95169820  DT.100820540  DT.100028746 
DT.121275499  DT.100820537  DT.95159127 

24/294 AceView cDNA sequences (see all 294 ):

CA306581 CB128868 AA255765 CA429724 CA417752 BE047761 AA454955 AA774201 
CR601585 BM806425 CR591778 T87833 AI418532 BM463689 AA489743 AA418970 
W89171 BX362644 CA748917 C20944 BE885288 T72026 AW193161 AA494116 

highest scoring ESTs for IFIT1:

AA074989 AA173630 AA249243 AA418854 AI132949 AL575223 AW167059 AW381055 BE047761 BE172900 

Unigene Cluster for IFIT1:

Interferon-induced protein with tetratricopeptide repeats 1
Hs.20315  [show with all ESTs]
Unigene Representative Sequence: AK095515


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000371804  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFIT1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFIT1

1 / 2 / 3

4 probe-sets matching IFIT1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

915_at2, 3 U95-A 1 1.00 1.00 0.98 0.96 M24594 0.60 1.00 0.82 1
32814_at2, 3 U95-A 3 1.00 0.94 0.99 1.04 M24594 0.60 1.00 0.82 1

203153_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001548 0.60 1.00 0.82 1

203153_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  IFIT1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAAGAAAGAG

SOURCE GeneReport for Unigene cluster: Hs.20315

Expression variation in blood from EXPOLDB for IFIT1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for IFIT1 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
IFIT11   -- interferon-induced protein with tetratricopeptide repeats more 80.82(n)
70.7(a)
488947  XM_843271.1  XP_848364.1 
chimpanzee
(Pan troglodytes)
IFIT11   -- interferon-induced protein with tetratricopeptide repeats more 99.16(n)
98.33(a)
450587  XM_507904.2  XP_507904.2 
rat
(Rattus norvegicus)
Ifit1lb1   -- interferon-induced protein with tetratricopeptide repeats more 70.9(n)
59.24(a)
294090  XM_220058.2  XP_220058.1 
mouse
(Mus musculus)
Ifit15
OTTMUSG000000166441
195
interferon-induced protein with tetratricopeptide repeats more5
predicted gene, OTTMUSG000000166441
69.9(n)1
58.06(a)1
6673731  XM_001000875.11  XP_001000875.11 
 AK0896085  AK1316695  (see all 26)
zebrafish
(Danio rerio)
LOC5673841   -- similar to VHSV-induced protein-4 46.43(n)
35.49(a)
567384  XM_690678.2  XP_695770.2 
About this table        Species with no ortholog for IFIT1

ENSEMBL Gene Tree for IFIT1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for IFIT1 gene
IFIT32  IFIT52  IFIT1L2  IFIT22  

Pseudogenes
2 related pseudogenes


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/72 NCBI SNPs in IFIT1 are shown (see all 72 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs3044781,2
A,C,F,H91140902(+) CTTATT/GTTAAA 1 -- ng51 tfbs317Minor allele frequency- G:0.23NS EU EA WA NA 1306
rs2154931,2
A,C,F,H91154150(+) tttgaC/Tataga 1 -- ng318Minor allele frequency- T:0.23EU EA WA 838
--
rs115530191,2
H91152404(-) GGAAGG/TGATTT 1 P/H mis14Minor allele frequency- T:0.00EU EA WA 404
--
rs115530181,2
H91152536(+) AAACCC/ATGAAT 1 H/P mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
--
rs78976021,2
A91140669(+) GATCAC/TGTATC 1 -- ng510--------
--
rs115530171,2
H91152526(+) TGGACC/GCTGAA 1 P/A mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
--
rs10629261,2
H91153159(+) ATTTCC/TACTAT 1 H/Y mis1 ese35Minor allele frequency- T:0.00MN EU EA WA 590
--
rs3032111,2
A,C,F,H,O91152477(+) GGAAAG/AAATTA 1 K/K syn1 trp39Minor allele frequency- A:0.03MN EU EA WA 1022
--
rs3032101,2
A,C,F,H91152657(+) CCAGAC/TAATGG 1 D/D syn1 ese37Minor allele frequency- T:0.42MN EU WA EA 828
rs3032151,2
A,C,F,H,O91146811(+) TGATAT/CATATG 1 -- int112Minor allele frequency- C:0.25EU EA WA NA 1200
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HapMap Linkage Disequilibrium images for IFIT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147690

1 PharmGKB disease relationship for IFIT1 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/23 PubMed articles for IFIT1 gene (see all 23 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3434 HGNC: 5407 AceView: IFIT1 Ensembl:ENSG00000185745 euGenes: HUgn3434
ECgene: IFIT1 H-InvDB: IFIT1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFIT1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFIT1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for IFIT1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFIT1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (IFIT1)
 Antibodies (IFIT1)
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(IFIT1)
 Antibodies (IFIT1)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for IFIT1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for IFIT1

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