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IFIH1 Gene

protein-coding GIFtS: 62

GC02M162831

interferon induced with helicase C domain 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.6.1.- ^³
Helicard ^³
Hlcd ^¹, ²
IDDM19 ^²
MDA-5 ^¹, ², ³
MDA5 ^¹, ², ³, ⁵
MGC133047 ^²
RH116 ^³
helicard ^²

Descriptions
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide ^²
Helicase with 2 CARD domains ^³
Interferon-induced with helicase C domain protein 1 ^³
Melanoma differentiation-associated protein 5 ^³
Murabutide down-regulated protein ^³
RNA helicase-DEAD box protein 116 ^³
interferon induced with helicase C domain 1 ^²
melanoma differentiation associated protein-5 ^²

External Ids
HGNC: 18873¹
Entrez Gene: 64135²
UniProtKB: Q9BYX4³
Ensembl: ENSG00000115267⁷

Search outside databases for aliases for IFIH1 gene

Previous GC identifers: GC02M163327 GC02M162949

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFIH1:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA

helicases. They are implicated in a number of cellular processes involving alteration of RNA

secondary structure such as translation initiation, nuclear and mitochondrial splicing, and

ribosome and spliceosome assembly. Based on their distribution patterns, some members of this

family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and

division. This gene encodes a DEAD box protein that is upregulated in response to treatment with

beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible

reprogramming of melanomas can be achieved by treatment with both these agents; treatment with

either agent alone only achieves reversible differentiation. [provided by RefSeq]

UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4

Function: RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote

message degradation by specific RNases. Seems to have growth suppressive properties. Involved in

innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during

viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the

activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines

such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential

for the production of interferons in response to picornaviruses

Gene Wiki entry for IFIH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFIH1 gene

Entrez Gene cytogenetic band: 2q24 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24.2

IFIH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M162831: (about GC identifiers)

Start:	162,831,835 bp from pter
End:	162,883,285 bp from pter
Size:	51,451 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4 (See protein sequence)

Recommended Name: Interferon-induced helicase C domain-containing protein 1

Size: 1025 amino acids; 116689 Da

Subunit: Interacts with MAVS. Interacts with V protein of Simian virus 5, Human parainfluenza virus

2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents

IFN-beta induction, and the further establishment of an antiviral state

Subcellular location: Cytoplasm. Nucleus (Potential). Note=May be found in the nucleus, during

apoptosis

Miscellaneous: In HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great

increase in the level of secreted viral p24 protein

Sequence caution: Sequence=AAH78180.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence;

PDB structures from and Proteopedia :

2RQB (3D)

3B6E (3D)

3GA3 (3D)

Secondary accessions: Q2NKL6 Q6DC96 Q86X56 Q96MX8 Q9H3G6

Alternative splicing: 2 isoforms: Q9BYX4-1 Q9BYX4-2

Post-translational modifications:

During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once

liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed

protein significantly sensitizes cells to DNA degradation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_071451.2

ENSEMBL proteins:

ENSP00000263642

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MDA5 )
	Human Recombinant Proteins from Abnova (IFIH1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for IFIH1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IFIH1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MDA5 ), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IFIH1

Assays for IFIH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BYX4

ProtoNet protein and cluster: Q9BYX4

1 Blocks protein family: IPB001315 CARD interaction domain

UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4

Similarity: Belongs to the helicase family

Similarity: Contains 2 CARD domains

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFIH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFIH1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022168

Applied Biosystems Silencer® siRNAs for IFIH1

Sigma-Aldrich siRNA for IFIH1

Sigma-Aldrich shRNA Panels and shRNA for IFIH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFIH1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022168
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022168
untagged cDNA clone in CMV expression vector: NM_022168

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022168

UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4

Function: RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote

message degradation by specific RNases. Seems to have growth suppressive properties. Involved in

innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during

viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the

activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines

such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential

for the production of interferons in response to picornaviruses

Induction: By IFN-beta and TNF-alpha

Enzyme Number (IUBMB): EC 3.6.1.-

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ifih1):

cellular

homeostasis/metabolism

immune system

life span-post-weaning/aging

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for IFIH1 (Your Favorite Gene powered by Ingenuity)

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Activation of IRF by Cytosolic Pattern Recognition Receptors
Role of RIG1-like Receptors in Antiviral Innate Immunity

GeneDecks IFIH1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IFIH1

5/36 Interacting proteins for IFIH1 (ENSP00000263642³ Q9BYX4²) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRF3	ENSP00000310127³	STRING (score=.933)
MAVS	ENSP00000350852³	STRING (score=.93)
RNF125	ENSP00000217740³	STRING (score=.927)
ALPI	ENSP00000295463³	STRING (score=.899)
ALPL	ENSP00000363965³	STRING (score=.899)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009615	response to virus	IEA	--
GO:0042981	regulation of apoptosis	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--
GO:0045087	innate immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFIH1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFIH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFIH1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022168

Sigma-Aldrich siRNA for IFIH1

Sigma-Aldrich shRNA Panels and shRNA for IFIH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022168

REFSEQ mRNAs for IFIH1 gene:

NM_022168.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022168

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022168
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022168
                                 untagged cDNA clone in CMV expression vector: NM_022168

Additional cDNA sequence:

AF095844.1 AK056293.1 AK292941.1 AK314611.1 AL080107.1 AY017378.1 BC007966.2 BC046208.1

BC078180.1 BC111750.1

9 DOTS entries:

DT.211382 DT.91910077 DT.91638689 DT.40125058 DT.40122158 DT.95365356 DT.100755538 DT.120948751

DT.120948780

24/76 AceView cDNA sequences (see all 76 ):

BC007966 BU189982 BM476961 AA650629 BM464502 AI783469 AF095844 BU902097

BQ233683 NM_022168 BX492926 BQ772836 BC078180 BC046208 BG391418 BF337464

AK056293 BM467983 BQ960157 CA423868 BX476433 BF686405 AY017378 AI718277

highest scoring ESTs for IFIH1:

AA134958 AA135031 AF095844 AW500093 AW503452 AY017378 BC007966 BC046208 BE244042 BF686405

Unigene Cluster for IFIH1:

Interferon induced with helicase C domain 1

Hs.163173 [show with all ESTs]

Unigene Representative Sequence: AK314611

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IFIH1 (see all 9 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·
SP1:							-		-								-				-
SP2:
SP3:																					-
SP4:																					-
SP5:

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IFIH1

1 Ensembl transcript including schematic representation:

ENST00000263642

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IFIH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFIH1

¹ / ² / ³

4 probe-sets matching IFIH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51920_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA134958	0.80	1.00	0.91	1
219209_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022168	0.60	1.00	0.82	1
219209_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555464_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IFIH1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACACAAAAAA

SOURCE GeneReport for Unigene cluster: Hs.163173
UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4
Tissue specificity: Widely expressed, at a low level. Expression is detected at slightly highest
levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFIH1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFIH1¹	--	interferon induced with helicase C domain 1	87.35(n) 83.43(a)	488371 XM_545493.2 XP_545493.2
cow (Bos taurus)	IFIH1¹	--	interferon induced with helicase C domain 1	87.84(n) 84.37(a)	535490 XM_615590.3 XP_615590.2
rat (Rattus norvegicus)	Ifih1¹	--	interferon induced with helicase C domain 1	81.15(n) 80.18(a)	499801 XM_575141.2 XP_575141.2
mouse (Mus musculus)	Ifih1^{1, 5}	2⁵	interferon induced with helicase C domain 1^{1, 5}	81.35(n)¹ 79.79(a)¹	71586¹ NM_027835.1¹ NP_082111.1¹ AA959954⁵ AF374384⁵ (see all 22)
chicken (Gallus gallus)	IFIH1¹	--	interferon induced with helicase C domain 1	68.12(n) 63.32(a)	424185 XM_422031.2 XP_422031.2

About this table Species with no ortholog for IFIH1

ENSEMBL Gene Tree for IFIH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for IFIH1 gene

DHX58² DICER1² DDX58²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/281 NCBI SNPs in IFIH1 are shown (see all 281 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1990760^1,2	A,C,F,H,O	162832297(+)	`CAGTGC/TTTTGT`	1	A/T	mis¹ ese³		11		MN EU EA WA NA	2562
	rs3747517^1,2	A,C,F,H	162837070(-)	`CGAACA/GTGAGA`	1	H/R	mis¹		18		EA NA EU WA	2958
	rs11897697^1,2	A,C,F,H	162883902(+)	`AGAAGA/CCAGGA`	1	--	ng3¹		10		EU EA WA	1016
	rs10930046^1,2	A,C,F,H	162846229(+)	`AATAAT/CGCCTC`	1	R/H	mis¹		16		NA EU EA WA	1366
	rs11891191^1,2	C,F,H	162831950(+)	`TCAATC/TAAGTG`	1	--	ut3¹		7		NA EU EA WA	552
	rs12470774^1,2	C,H	162858374(+)	`TCCAAG/TACTTT`	1	L/I	mis¹		4		EU EA WA	414
--	rs11896598^1,2	C	162883789(+)	`TGAACA/TGGGAG`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs12474918^1,2	H	162858416(+)	`ACTTGT/AGTCTG`	1	S/T	mis¹ ese³		4		EU EA WA	406
	rs12479043^1,2	A,C,F	162846117(+)	`TGCTTC/GGTGGC`	1	T/T	syn¹ ese³		1		NA	46
	rs13418718^1,2	F,H	162837129(+)	`GCTCTG/AGCTCG`	1	A/A	syn¹ ese³		3		EU EA	290

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HapMap Linkage Disequilibrium images for IFIH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606951

UniProtKB/Swiss-Prot: IFIH1_HUMAN, Q9BYX4

Genetic variation in IFIH1 is associated with insulin-dependent diabetes mellitus 19

(IDDM19) [MIM:610155]

7 Novoseek disease relationships for IFIH1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	66.74	35	11805321 (4), 14676839 (2), 17142768 (1), 17541283 (1) (see all 27)
virus infection	64.25	7	18971330 (1), 17651439 (1), 19005739 (1), 17868652 (1) (see all 6)
influenza	27.55	3	16797201 (3)
hepatitis c	24.72	1	16116171 (1)
cancer	0.00	2	14676839 (1), 11805321 (1)
inflammation	0.00	1	19005739 (1)
tumors	0.00	1	11805321 (1)

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Human Gene Mutation Database: IFIH1
Human Genome Epidemiology Navigator: IFIH1 (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/77 PubMed articles for IFIH1 gene (see all 77 ):

mda-5: an interferon-inducible putative RNA helicase with double- stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. (PubMed id 11805321)^{1, 3, 4} Kang D.-C....Fisher P.B. (2002)
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. (PubMed id 15563593)^{1, 3, 4} Andrejeva J.... Randall R.E. (2004)
A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication. (PubMed id 14645903)^{1, 3, 4} Cocude C.... Bahr G.M. (2003)
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. (PubMed id 16699517)^{1, 3, 4} Smyth D.J.... Todd J.A. (2006)
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. (PubMed id 16177806)^{3, 4} Meylan E.... Tschopp J. (2005)
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. (PubMed id 16127453)^{3, 4} Kawai T.... Akira S. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. (PubMed id 12015121)^{3, 4} Kovacsovics M....Tschopp J. (2002)
Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. (PubMed id 14676839)^{1, 3} Kang D.C....Fisher P.B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 64135	HGNC: 18873	AceView: IFIH1	Ensembl:ENSG00000115267	euGenes: HUgn64135
ECgene: IFIH1	H-InvDB: IFIH1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IFIH1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for IFIH1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IFIH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFIH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for IFIH1		Antibodies for IFIH1
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Antibodies for IFIH1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IFIH1 Gene at Home site.
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IFIH1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for IFIH1

Summaries
for IFIH1

Genomic Location
for IFIH1

Proteins
for IFIH1

Protein Domains/
Families
for IFIH1

Gene Function
for IFIH1

Pathways & Interactions
for IFIH1

Drugs & Compounds
for IFIH1

Transcripts
for IFIH1

Expression
for IFIH1

Orthologs
for IFIH1

Paralogs
for IFIH1

SNPs/Variants
for IFIH1

Disorders & Mutations
for IFIH1

Medical News
for IFIH1

Publications
for IFIH1

Search for IFIH1

Genome Databases showing IFIH1

Other Databases showing IFIH1

Specialized Databases showing IFIH1

Licensable Technologies
for IFIH1

Services
for IFIH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFIH1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor IFIH1

Summariesfor IFIH1

Genomic Locationfor IFIH1

Proteinsfor IFIH1

Protein Domains/Familiesfor IFIH1

Gene Functionfor IFIH1

Pathways & Interactionsfor IFIH1

Drugs & Compoundsfor IFIH1

Transcriptsfor IFIH1

Expression for IFIH1

Orthologsfor IFIH1

Paralogsfor IFIH1

SNPs/Variantsfor IFIH1

Disorders & Mutationsfor IFIH1

Medical Newsfor IFIH1

Publicationsfor IFIH1

Search for IFIH1

Genome Databases showing IFIH1

Other Databases showing IFIH1

Specialized Databases showing IFIH1

Licensable Technologiesfor IFIH1

Servicesfor IFIH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFIH1

Summaries
for IFIH1

Genomic Location
for IFIH1

Proteins
for IFIH1

Protein Domains/
Families
for IFIH1

Gene Function
for IFIH1

Pathways & Interactions
for IFIH1

Drugs & Compounds
for IFIH1

Transcripts
for IFIH1

Expression
for IFIH1

Orthologs
for IFIH1

Paralogs
for IFIH1

SNPs/Variants
for IFIH1

Disorders & Mutations
for IFIH1

Medical News
for IFIH1

Publications
for IFIH1

Licensable Technologies
for IFIH1

Services
for IFIH1