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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFI6 Gene

protein-coding   GIFtS: 56
GCID: GC01M027992

Interferon, Alpha-Inducible Protein 6

(Previous names: interferon, alpha-inducible protein (clone IFI-6-16))
(Previous symbol: G1P3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 61 2     FAM14C2
G1P31 2 3 5     IFI-6-162
Interferon-Induced Protein 6-162 3     Interferon Alpha-Inducible Protein 62
IFI6162 5     Interferon, Alpha-Inducible Protein Clone IFI-6-162
Interferon, Alpha-Inducible Protein (Clone IFI-6-16)1     Ifi-6-163
6-162     

External Ids:    HGNC: 40541   Entrez Gene: 25372   Ensembl: ENSG000001267097   OMIM: 1475725   UniProtKB: P099123   

Export aliases for IFI6 gene to outside databases

Previous GC identifers: GC01M027865 GC01M026248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFI6 Gene:
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a
critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide
repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second
exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat
units as splice donor sites have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFI6 Gene: 
IFI6 (interferon, alpha-inducible protein 6) is a protein-coding gene. Diseases associated with IFI6 include hepatitis b, and gastric cancer, and among its related super-pathways are Immune response IFN alpha/beta signaling pathway and Interferon Signaling. GO annotations related to this gene include protein binding. An important paralog of this gene is IFI27L2.

Gene Wiki entry for IFI6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFI6 gene promoter:
         Ik-2   STAT3   PPAR-gamma2   IRF-1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI6 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFI6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35

IFI6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027992:  view genomic region     (about GC identifiers)

Start:
27,992,572 bp from pter      End:
27,998,729 bp from pter
Size:
6,158 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 6 precursor  
Size: 130 amino acids; 12927 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8
Alternative splicing: 3 isoforms:  P09912-1   P09912-2   P09912-3   

Explore the universe of human proteins at neXtProt for IFI6: NX_P09912

Explore proteomics data for IFI6 at MOPED 

IFI6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFI6 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_002029.3  NP_075010.1  NP_075011.1  

ENSEMBL proteins: 
 ENSP00000354736   ENSP00000342513   ENSP00000355152  
Reactome Protein details: P09912
Human Recombinant Protein Products for IFI6: 
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Cloud-Clone Corp. Proteins for IFI6 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA15685448
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

IFI6 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for IFI6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR009311 Interferon-induced_6-16

Graphical View of Domain Structure for InterPro Entry P09912

ProtoNet protein and cluster: P09912

1 Blocks protein domain: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912
Similarity: Belongs to the IFI6/IFI27 family


IFI6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFI6_HUMAN, P09912
Induction: By alpha and beta interferons

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI15685448
     
IFI6 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for IFI6:
 Increased cell death HMECs cel  Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IFI6 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFI6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI6 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFI6 

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidIFI6 3' UTR sequence
Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFI6 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response IFN alpha/beta signaling pathway
Immune response IFN alpha/beta signaling pathway0.71
Interferon alpha/beta signaling0.45
2Interferon Signaling
Interferon Signaling0.61
Cytokine Signaling in Immune system0.61
3Immune System
Immune System0.56
4Type II interferon signaling (IFNG)
Type II interferon signaling (IFNG)

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for IFI6
    Immune response IFN alpha/beta signaling pathway


1 GeneGo (Thomson Reuters) Pathway for IFI6
    Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFI6
    Type II interferon signaling (IFNG)

4        Reactome Pathways for IFI6
    Interferon alpha/beta signaling
Cytokine Signaling in Immune system
Interferon Signaling
Immune System



IFI6 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFI6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for IFI6 (P099123 ENSP000003425134) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
InteractantInteraction Details
GeneCardExternal ID(s)
CIB1Q998283, ENSP000003338734I2D: score=1 STRING: ENSP00000333873
ADARENSP000003574594STRING: ENSP00000357459
ENSG00000206435ENSP000003729754STRING: ENSP00000372975
ENSG00000223532ENSP000004008424STRING: ENSP00000400842
ENSG00000228299ENSP000003978674STRING: ENSP00000397867
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001836release of cytochrome c from mitochondria IMP15685448
GO:0006955immune response TAS3017706
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP15685448
GO:0051902negative regulation of mitochondrial depolarization IMP15685448

IFI6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFI6

Search CenterWatch for drugs/clinical trials and news about IFI6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFI6 gene (3 alternative transcripts): 
NM_002038.3  NM_022872.2  NM_022873.2  

Unigene Clusters for IFI6:

Interferon, alpha-inducible protein 6
Hs.523847  [show with all ESTs], Hs.730125  [show with all ESTs]
Unigene Representative Sequences: BM458012, DB152637
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000361157(uc001bon.1 uc001boo.1 uc001bop.1) ENST00000339145
ENST00000362020
miRNA
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Inhib. RNA
Products:
     
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI6
Sirion Biotech Customized lentivirus for stable overexpression of IFI6 
                     Customized lentivirus expression plasmids for stable overexpression of IFI6 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI6
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI6

Additional mRNA sequence: 

AB164057.1 AB306177.1 AF326334.1 AF387742.1 AF387745.1 AF387746.1 AF387747.1 AF387748.1 
AF387749.1 AF387753.1 AF387755.1 AF387756.1 AF387758.1 AF387762.1 AF395520.1 AF395521.1 
AF395522.1 AF395527.1 AF395528.1 AF395529.1 AF395530.1 AF397441.1 AF397442.1 AF397443.1 
AF397444.1 AF397446.1 AF430686.1 AF430687.1 AF430688.1 AF430692.1 AF430695.1 AF430697.1 
AY006112.1 AY006307.1 AY029331.1 AY032920.1 AY032921.1 AY124783.1 AY124785.1 AY124787.1 
AY124788.1 AY124794.1 AY124795.1 AY190096.1 AY751838.1 AY751864.1 HM467880.1 L06890.1 
M64353.1 M73466.1 M90475.1 X51795.1 X58809.1 X74850.1 X86104.1 X86105.1 
X86106.1 X86110.1 X86137.1 X92885.1 Y15203.1 Z77845.1 

24/35 DOTS entries (see all 35):

DT.75133179  DT.91920762  DT.95135143  DT.91963304  DT.98084055  DT.100766780  DT.95166405  DT.121330646 
DT.121076203  DT.95166424  DT.99927243  DT.100642481  DT.100032309  DT.100824648  DT.121075869  DT.92456573 
DT.100032301  DT.100756449  DT.100778969  DT.100824649  DT.102841081  DT.121076536  DT.121076626  DT.121076903 

24/247 AceView cDNA sequences (see all 247):

N27839 CD671420 BT006850 AI521538 AA075776 AI277855 BM354146 D56126 
AA075262 CB124292 AA075171 BQ083787 CB151563 BM142149 CB112693 BM263192 
AA367248 AI873959 BU542092 BQ083980 BQ083495 Z20822 CB127004 BC015603 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IFI6    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1:                          -                           
SP2:                    -     -                           
SP3:                                                      


ECgene alternative splicing isoforms for IFI6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFI6 expression in normal human tissues (normalized intensities)      IFI6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGCCGACGAT
IFI6 Expression
About this image


IFI6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         monocytes   
 
 Primitive Streak (Early Embryonic Tissues)
         Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
 
 Cartilage (Muscoskeletal System)
         Knee Normal Human Articular chondrocytes (knNHAC)   

See IFI6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFI6

SOURCE GeneReport for Unigene clusters: Hs.523847 Hs.730125
    SABiosciences Expression via Pathway-Focused PCR Arrays including IFI6: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Apoptosis 384HT in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFI6 gene from 4/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia IFI61 interferon, alpha-inducible protein 6 77.44(n)
70.68(a)
  478170  XM_535344.3  XP_535344.1 
chicken
(Gallus gallus)
Aves IFI27L26
interferon alpha-inducible protein 27-like protein...
36(a)
1 → many
23(4295102-4296014)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
43(a)
20(a)
many ↔ many
many ↔ many
GL343498.1(96838-99481)
GL343558.1(288340-297430)
zebrafish
(Danio rerio)
Actinopterygii zgc:1527916
zgc:1230686
(see all 8)
zgc:123068
(see all 8)
42(a)
41(a)
(see all 8)
many ↔ many
many ↔ many
(see all 8)
13(38014818-38017588)
13(38003194-38005739)


ENSEMBL Gene Tree for IFI6 (if available)
TreeFam Gene Tree for IFI6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFI6 gene
IFI27L22  IFI272  IFI27L12  
3 SIMAP similar genes for IFI6 using alignment to 1 protein entry:     IFI6_HUMAN:
IFI27L2    IFI27    IFI27L1

IFI6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/215 SNPs in IFI6 are shown (see all 215)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1878403661,2
--27992088(+) TTGCCA/GAGCCC 3 -- ds50010--------
rs568981151,2
C,F--27992112(+) GTTACG/ACCCTT 3 -- ds50011Minor allele frequency- A:0.19EA 120
rs28084301,2
C,F,A,H--27992287(-) AGGCTC/TGATTC 3 -- ds500125Minor allele frequency- T:0.05NS EA NA WA CSA 1703
rs800027221,2
C,F--27992398(+) TCTGAA/CGGCAT 3 -- ds50011Minor allele frequency- C:0.02WA 118
rs1921642021,2
--27992479(+) GACTCA/GAGGGG 3 -- ds50010--------
rs793292071,2
C,F--27992624(+) GGGGAG/AAGTGA 3 -- ut314Minor allele frequency- A:0.29CSA WA 123
rs1826255751,2
--27992659(+) ATCGTC/TGGCGC 3 -- ut310--------
rs1458778011,2
C--27992662(+) GTCGGC/TGCATG 3 -- ut310--------
rs1489985791,2
--27992709(+) CACTTA/GAGGCT 3 -- ut310--------
rs1877001061,2
--27992741(+) ACTATA/GTTCGC 3 -- ut310--------

HapMap Linkage Disequilibrium report for IFI6 (27992572 - 27998729 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for IFI6:    About this table     
Variant IDTypeSubtypePubMed ID
esv2745763CNV Deletion23290073
esv2745785CNV Deletion23290073
esv2745774CNV Deletion23290073
nsv522842CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IFI6
DNA2.0 Custom Variant and Variant Library Synthesis for IFI6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147572    OMIM disorders: --

5 diseases for IFI6:    About MalaCards
hepatitis b    gastric cancer    myeloma    ovarian cancer
hepatitis


IFI6 for disorders           About GeneDecksing

Genetic Association Database (GAD): IFI6
Human Genome Epidemiology (HuGE) Navigator: IFI6 (2 documents)

Export disorders for IFI6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFI6 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with IFI6)
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  1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
  2. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript. (PubMed id 7596809)1, 2 Turri M.G.... Porter A.C.G. (1995)
  5. Characterization of a human gene inducible by alpha- and beta- interferons and its expression in mouse cells. (PubMed id 3017706)1, 2 Kelly J.M....Kerr I.M. (1986)
  6. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. (PubMed id 17823654)1, 9 Cheriyath V....Borden E.C. (2007)
  7. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PubMed id 15685448)1, 9 Tahara E. Jr.... Tahara E. (2005)
  8. G1P3, an interferon- and estrogen-induced survival pro tein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breas t cancer. (PubMed id 21996729)1 Cheriyath V....Borden E.C. (2012)
  9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2537 HGNC: 4054 AceView: G1P3 Ensembl:ENSG00000126709 euGenes: HUgn2537
ECgene: IFI6 H-InvDB: IFI6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFI6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFI6 gene:
Search GeneIP for patents involving IFI6

GeneCards and IP:
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