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IFI6 Gene

protein-coding   GIFtS: 56
GCID: GC01M027992

Interferon, Alpha-Inducible Protein 6

(Previous names: interferon, alpha-inducible protein (clone IFI-6-16))
(Previous symbol: G1P3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha-Inducible Protein 61 2     FAM14C2
G1P31 2 3 5     IFI-6-162
Interferon-Induced Protein 6-162 3     Interferon Alpha-Inducible Protein 62
IFI6162 5     Interferon, Alpha-Inducible Protein Clone IFI-6-162
Interferon, Alpha-Inducible Protein (Clone IFI-6-16)1     Ifi-6-163
6-162     

External Ids:    HGNC: 40541   Entrez Gene: 25372   Ensembl: ENSG000001267097   OMIM: 1475725   UniProtKB: P099123   

Export aliases for IFI6 gene to outside databases

Previous GC identifers: GC01M027865 GC01M026248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFI6 Gene:
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a
critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide
repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second
exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat
units as splice donor sites have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFI6 Gene:
IFI6 (interferon, alpha-inducible protein 6) is a protein-coding gene. Diseases associated with IFI6 include hepatitis b, and psoriasis.

Gene Wiki entry for IFI6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFI6 gene promoter:
         Ik-2   STAT3   PPAR-gamma2   IRF-1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI6 promoter sequence
   Search Chromatin IP Primers for IFI6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFI6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35

IFI6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027992:  view genomic region     (about GC identifiers)

Start:
27,992,572 bp from pter      End:
27,998,729 bp from pter
Size:
6,158 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 6 precursor  
Size: 130 amino acids; 12927 Da
Secondary accessions: Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8
Alternative splicing: 3 isoforms:  P09912-1   P09912-2   P09912-3   

Explore the universe of human proteins at neXtProt for IFI6: NX_P09912

Explore proteomics data for IFI6 at MOPED


See IFI6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_002029.3  NP_075010.1  NP_075011.1  

ENSEMBL proteins: 
 ENSP00000354736   ENSP00000342513   ENSP00000355152  
Reactome Protein details: P09912

IFI6 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for IFI6
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Novus Biologicals IFI6 Protein
Novus Biologicals IFI6 Lysates
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Cloud-Clone Corp. Proteins for IFI6

IFI6 Antibody Products:

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OriGene Antibodies for IFI6
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Novus Biologicals IFI6 Antibodies
Abcam antibodies for IFI6
Cloud-Clone Corp. Antibodies for IFI6
Search ThermoFisher Antibodies for IFI6
LSBio Antibodies in human, mouse, rat for IFI6

IFI6 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFI6
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFI6
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IFI6
Cloud-Clone Corp. CLIAs for IFI6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009311 IFI6/IFI27

Graphical View of Domain Structure for InterPro Entry P09912

ProtoNet protein and cluster: P09912

1 Blocks protein domain: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912
Similarity: Belongs to the IFI6/IFI27 family


IFI6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFI6_HUMAN, P09912
Induction: By alpha and beta interferons

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI15685448
     
IFI6 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for IFI6:
 Increased cell death HMECs cel  Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFI6
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFI6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI6
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFI6

miRNA
Products:
    
miRTarBase miRNAs that target IFI6:
hsa-mir-375 (MIRT019676)

Block miRNA regulation of human, mouse, rat IFI6 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IFI6
SwitchGear 3'UTR luciferase reporter plasmidIFI6 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IFI6
Predesigned siRNA for gene silencing in human, mouse, rat IFI6

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFI6

Clone
Products:
     
OriGene clones in human, mouse for IFI6 (see all 15)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): IFI6 (NM_002038)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI6

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFI6
Browse ESI BIO Cell Lines and PureStem Progenitors for IFI6 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFI6_HUMAN, P09912: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion4
plasma membrane4
extracellular3
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA15685448
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

IFI6 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFI6 About    
See pathways by source

SuperPathContained pathways About
1Immune response IFN alpha beta signaling pathway
Immune response IFN alpha beta signaling pathway0.69
Interferon alpha/beta signaling0.43
2Interferon Signaling
Interferon Signaling0.59
Cytokine Signaling in Immune system0.59
3Type II interferon signaling (IFNG)
Type II interferon signaling (IFNG)

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for IFI6
    Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFI6
    Type II interferon signaling (IFNG)

1 Reactome Pathway for IFI6
    Interferon alpha/beta signaling



IFI6 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI6: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Apoptosis 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IFI6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for IFI6 (P099123 ENSP000003425134) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
InteractantInteraction Details
GeneCardExternal ID(s)
CIB1Q998283, ENSP000003338734I2D: score=1 STRING: ENSP00000333873
ADARENSP000003574594STRING: ENSP00000357459
ENSG00000206435ENSP000003729754STRING: ENSP00000372975
ENSG00000223532ENSP000004008424STRING: ENSP00000400842
ENSG00000228299ENSP000003978674STRING: ENSP00000397867
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001836release of cytochrome c from mitochondria IMP15685448
GO:0006955immune response TAS3017706
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP15685448
GO:0051902negative regulation of mitochondrial depolarization IMP15685448

IFI6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFI6



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFI6 gene (3 alternative transcripts): 
NM_002038.3  NM_022872.2  NM_022873.2  

Unigene Cluster for IFI6:

Interferon, alpha-inducible protein 6
Hs.523847  [show with all ESTs]
Unigene Representative Sequence: BM458012
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000361157(uc001bon.1 uc001boo.1 uc001bop.1) ENST00000339145
ENST00000362020
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IFI6 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IFI6
SwitchGear 3'UTR luciferase reporter plasmidIFI6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IFI6
Predesigned siRNA for gene silencing in human, mouse, rat IFI6
Clone
Products:
     
OriGene clones in human, mouse for IFI6 (see all 15)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): IFI6 (NM_002038)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI6
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IFI6
OriGene qSTAR qPCR primer pairs in human, mouse for IFI6
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFI6
  QuantiTect SYBR Green Assays in human, mouse, rat IFI6
  QuantiFast Probe-based Assays in human, mouse, rat IFI6

Additional mRNA sequence: 

AK024814.1 AK314488.1 BC011601.2 BC015603.2 BT006850.1 X02492.1 

11 DOTS entries:

DT.75133179  DT.91920762  DT.121330646  DT.100824648  DT.100756449  DT.100824649  DT.87016789  DT.100030115 
DT.100824647  DT.121330644  DT.97763192 

Selected AceView cDNA sequences (see all 247):

BM263192 AA075262 CB151563 BQ083787 BU542092 AA075776 BM354146 BT006850 
CD671420 AI277855 AI521538 CB124292 AA075171 AI873959 N27839 Z20822 
BM142149 BQ083980 BQ083495 AA367248 CB112693 D56126 BE396081 BM768898 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IFI6    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1:                          -                           
SP2:                    -     -                           
SP3:                                                      


ECgene alternative splicing isoforms for IFI6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFI6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGCCGACGAT
IFI6 Expression
About this image


IFI6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Adipose (Muscoskeletal System)
         White adipocyte-like cells
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical Arteries
 
 Lung (Respiratory System)
 
 Placenta (Extraembryonic Tissues)
IFI6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFI6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.523847
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI6: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Apoptosis 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IFI6
OriGene qSTAR qPCR primer pairs in human, mouse for IFI6
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFI6
QuantiTect SYBR Green Assays in human, mouse, rat IFI6
QuantiFast Probe-based Assays in human, mouse, rat IFI6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for IFI6 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia IFI61 interferon, alpha-inducible protein 6 78.2(n)
71.43(a)
  478170  XM_535344.4  XP_535344.1 


ENSEMBL Gene Tree for IFI6 (if available)
TreeFam Gene Tree for IFI6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFI6 gene
3 SIMAP similar genes for IFI6 using alignment to 1 protein entry:     IFI6_HUMAN:
IFI27L2    IFI27    IFI27L1

IFI6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFI6 (see all 215)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1878403661,2
--27992088(+) TTGCCA/GAGCCC 3 -- ds50010--------
rs568981151,2
C,F--27992112(+) GTTACG/ACCCTT 3 -- ds50011Minor allele frequency- A:0.19EA 120
rs28084301,2
C,F,A,H--27992287(-) AGGCTC/TGATTC 3 -- ds500125Minor allele frequency- T:0.05NS EA NA WA CSA 1703
rs800027221,2
C,F--27992398(+) TCTGAA/CGGCAT 3 -- ds50011Minor allele frequency- C:0.02WA 118
rs1921642021,2
--27992479(+) GACTCA/GAGGGG 3 -- ds50010--------
rs793292071,2
C,F--27992624(+) GGGGAG/AAGTGA 3 -- ut314Minor allele frequency- A:0.29CSA WA 123
rs1826255751,2
--27992659(+) ATCGTC/TGGCGC 3 -- ut310--------
rs1458778011,2
C--27992662(+) GTCGGC/TGCATG 3 -- ut310--------
rs1489985791,2
--27992709(+) CACTTA/GAGGCT 3 -- ut310--------
rs1877001061,2
--27992741(+) ACTATA/GTTCGC 3 -- ut310--------

HapMap Linkage Disequilibrium report for IFI6 (27992572 - 27998729 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for IFI6:    About this table    
Variant IDTypeSubtypePubMed ID
esv2745763CNV Deletion23290073
esv2745785CNV Deletion23290073
esv2745774CNV Deletion23290073
nsv522842CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFI6
DNA2.0 Custom Variant and Variant Library Synthesis for IFI6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147572    OMIM disorders: --

6 diseases for IFI6:    
About MalaCards
hepatitis b    psoriasis    myeloma    ovarian cancer
hepatitis    breast cancer


IFI6 for disorders           About GeneDecksing

Genetic Association Database (GAD): IFI6
Human Genome Epidemiology (HuGE) Navigator: IFI6 (2 documents)

Export disorders for IFI6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFI6 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with IFI6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
  2. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (BMC Genomics 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript. (PubMed id 7596809)1, 2 Turri M.G.... Porter A.C.G. (Nucleic Acids Res. 1995)
  5. Characterization of a human gene inducible by alpha- and beta- interferons and its expression in mouse cells. (PubMed id 3017706)1, 2 Kelly J.M....Kerr I.M. (EMBO J. 1986)
  6. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. (PubMed id 17823654)1, 9 Cheriyath V....Borden E.C. (J. Clin. Invest. 2007)
  7. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PubMed id 15685448)1, 9 Tahara E. Jr.... Tahara E. (Cancer Immunol. Immunother. 2005)
  8. G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer. (PubMed id 21996729)1 Cheriyath V....Borden E.C. (Oncogene 2012)
  9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2537 HGNC: 4054 AceView: G1P3 Ensembl:ENSG00000126709 euGenes: HUgn2537
ECgene: IFI6 H-InvDB: IFI6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFI6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFI6 gene:
Search GeneIP for patents involving IFI6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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