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Aliases & Descriptions for IFI6
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 6-16 1 , 2 FAM14C 1 , 2 G1P3 2 , 3 IFI-6-16 1 , 2 IFI616 1 , 2 Ifi-6-16 3 OTTHUMP00000003605 2 OTTHUMP00000003606 2 OTTHUMP00000003607 2
Descriptions Interferon-induced protein 6-16 3 interferon, alpha-inducible protein (clone IFI-6-16) 1 interferon, alpha-inducible protein 6 2 interferon, alpha-inducible protein clone IFI-6-16 2
Search outside databases for aliases for IFI6 gene
Summaries for IFI6 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for IFI6 : This gene was first identified as one of the many genes induced by interferon. The encoded proteinmay play a critical role in the regulation of apoptosis. A minisatellite that consists of 26repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensussequence begins near the end of the second exon. Alternatively spliced transcript variants thatencode different isoforms by using the two downstream repeat units as splice donor sites have beendescribed. [provided by RefSeq] Gene Wiki entry for IFI6
Genomic Location for IFI6
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the IFI6 gene Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35 IFI6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M027865:
(about GC identifiers )
Start:
27,865,159 bp from pter
End:
27,871,311 bp from pter
Size:
6,153 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004610.18 Proteins for IFI6
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 (See
protein sequence )Recommended Name: Interferon alpha-inducible protein 6 precursor Size : 130 amino acids; 12927 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q13141 Q13142 Q969M8Alternative splicing : 3 isoforms : P09912-1 P09912-2 P09912-3
REFSEQ proteins (3 alternative transcripts):
NP_002029.3 NP_075010.1 NP_075011.1 ENSEMBL proteins: ENSP00000363070 ENSP00000363072 ENSP00000355152 ENSP00000354736 ENSP00000342513 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for IFI6: Assays for IFI6:
Protein
Domains/ Families for IFI6(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P09912 ProtoNet protein and cluster: P09912
1 Blocks protein family : IPB009311 Interferon-induced 6-16 UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 Similarity : Belongs to the IFI6/IFI27 family
Gene Function for IFI6
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_002038 Applied Biosystems Silencer ® siRNAs for IFI6 Sigma-Aldrich siRNA for IFI6 Sigma-Aldrich shRNA for IFI6 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_002038                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_002038                                  untagged cDNA clones in CMV expression vector (see all 4 ): AB019565  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: AB019565 UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 Induction : By alpha and beta interferons
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for IFI6
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for IFI6 (ENSP00000342513 3 ) via UniProtKB, MINT, and/or STRING About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for IFI6 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for IFI6
Transcripts for IFI6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_002038 Sigma-Aldrich siRNA for IFI6 Sigma-Aldrich shRNA for IFI6 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002038 NM_022872 NM_022873
REFSEQ mRNAs for IFI6 gene (3 alternative transcripts): NM_002038.3 NM_022872.2 NM_022873.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002038 NM_022872 NM_022873
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_002038                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_002038                                  untagged cDNA clones in CMV expression vector (see all 4 ): AB019565  
Additional cDNA sequence: AK024814.1 AK314488.1 BC011601.2 BC015603.2 BT006850.1 X02492.1
11 DOTS entries : DT.75133179 DT.91920762 DT.121330646 DT.100824648 DT.100756449 DT.100824649 DT.87016789 DT.100824647 DT.121330644 DT.100030115 DT.97763192
24/247 AceView cDNA sequences (see all 247
):CB112693 AA367248 BQ083495 D56126 AA075171 CB151563 AA075262 BM354146 CD671420 Z20822 BQ083787 BQ083980 AI873959 AI277855 BT006850 BU542092 AI521538 AA075776 CB124292 BM263192 N27839 BM142149 BU857413 CD050482
highest scoring ESTs for IFI6 :AA233266 AK024814 AU077025 BC011601 BC015603 BE887546 BG336311 BG435732 BG477513 BG481063
Unigene Cluster for IFI6: Interferon, alpha-inducible protein 6 Hs.523847 [show with all ESTs ] Unigene Representative Sequence: BM458012 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for IFI6 ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b SP1 :         -           SP2 :       -   -           SP3 :                  
About this scheme ECgene alternative splicing isoforms for IFI6 5 Ensembl transcripts including schematic representations : ENST00000373959
ENST00000373961
ENST00000362020
ENST00000361157
ENST00000339145
Expression for IFI6
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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IFI6 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for IFI6 1 / 2 / 3
3 probe-sets matching IFI6 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CGCCGACGATSOURCE GeneReport for Unigene cluster: Hs.523847
Orthologs for IFI6
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for IFI6 gene from 3 species
About this table Species with no ortholog for IFI6 ENSEMBL Gene Tree for IFI6 Paralogs for IFI6 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for IFI6 gene IFI27L2 2 IFI27 2 IFI27L1 2
SNPs/Variants for IFI6 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for IFI6 (up to first 250kb)
Disorders & Mutations for IFI6
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 147572
Medical News for IFI6 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for IFI6 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for IFI6 gene (see all 16
):
Search for IFI6
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IFI6
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing IFI6
(According to HUGE )
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--
Specialized Databases showing IFI6 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for IFI6 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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