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IFI6 Gene

protein-coding   GIFtS: 50

GC01M027865
interferon, alpha-inducible protein 6
(Previous names: interferon, alpha-inducible protein (clone IFI-6-16) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: G1P3)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
6-16 1, 2
FAM14C 1, 2
G1P3 2, 3
IFI-6-16 1, 2
IFI616 1, 2
Ifi-6-16 3
OTTHUMP00000003605 2
OTTHUMP00000003606 2
OTTHUMP00000003607 2
Descriptions
Interferon-induced protein 6-16 3
interferon, alpha-inducible protein (clone IFI-6-16) 1
interferon, alpha-inducible protein 6 2
interferon, alpha-inducible protein clone IFI-6-16 2
External Ids
HGNC: 40541
Entrez Gene: 25372
UniProtKB: P099123
Ensembl: ENSG000001267097
Search outside databases for aliases for IFI6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFI6:
This gene was first identified as one of the many genes induced by interferon. The encoded protein
may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26
repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus
sequence begins near the end of the second exon. Alternatively spliced transcript variants that
encode different isoforms by using the two downstream repeat units as splice donor sites have been
described. [provided by RefSeq]

Gene Wiki entry for IFI6
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFI6 gene  

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35

IFI6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027865:     (about GC identifiers)

Start:
27,865,159 bp from pter
End:
27,871,311 bp from pter
Size:
6,153 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004610.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 6 precursor  
Size: 130 amino acids; 12927 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q13141 Q13142 Q969M8
Alternative splicing: 3 isoforms:  P09912-1   P09912-2   P09912-3   

REFSEQ proteins (3 alternative transcripts): 
NP_002029.3  NP_075010.1  NP_075011.1  


ENSEMBL proteins: 
ENSP00000363070 ENSP00000363072 ENSP00000355152 ENSP00000354736 ENSP00000342513 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (G1P3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA18029348
GO:0005739 mitochondrion IDA15685448
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

Antibodies for IFI6: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for IFI6
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (G1P3)
Novus Biologicals Antibodies for IFI6

Assays for IFI6: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR009311 Interferon-induced_6-16


   GeneDecks  IFI6 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P09912

ProtoNet protein and cluster: P09912

1 Blocks protein family: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912
Similarity: Belongs to the IFI6/IFI27 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFI6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (G1P3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002038

              Applied Biosystems Silencer® siRNAs for IFI6

              Sigma-Aldrich siRNA for IFI6  
                     Sigma-Aldrich shRNA for IFI6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IFI6
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002038
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002038
                                 untagged cDNA clones in CMV expression vector (see all 4): AB019565 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: AB019565

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912
Induction: By alpha and beta interferons

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI15685448
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for IFI6
 Immune response IFN alpha/beta signaling pathway

   GeneDecks  IFI6 for the pathways selected above  
About GeneDecksing


3 Interacting proteins for IFI6 (ENSP000003425133) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
CYFIP2ENSP000003667993STRING (score=.876)
ISG15ENSP000003686993STRING (score=.74)
--ENSP000003695523STRING (score=.774)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001836 release of cytochrome c from mitochondria IMP15685448
GO:0006916 anti-apoptosis IMP15685448
GO:0006955 immune response TAS3017706
GO:0043154 negative regulation of caspase activity IMP15685448
GO:0051902 negative regulation of mitochondrial depolarization IMP15685448
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFI6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFI6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (G1P3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002038

              Sigma-Aldrich siRNA for IFI6  
                     Sigma-Aldrich shRNA for IFI6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002038  NM_022872  NM_022873  

REFSEQ mRNAs for IFI6 gene (3 alternative transcripts): 

NM_002038.3   NM_022872.2   NM_022873.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002038  NM_022872  NM_022873  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002038
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002038
                                 untagged cDNA clones in CMV expression vector (see all 4): AB019565 

Additional cDNA sequence: 

AK024814.1 AK314488.1 BC011601.2 BC015603.2 BT006850.1 X02492.1 

11 DOTS entries:

DT.75133179  DT.91920762  DT.121330646  DT.100824648  DT.100756449  DT.100824649  DT.87016789  DT.100824647 
DT.121330644  DT.100030115  DT.97763192 

24/247 AceView cDNA sequences (see all 247 ):

CB112693 AA367248 BQ083495 D56126 AA075171 CB151563 AA075262 BM354146 
CD671420 Z20822 BQ083787 BQ083980 AI873959 AI277855 BT006850 BU542092 
AI521538 AA075776 CB124292 BM263192 N27839 BM142149 BU857413 CD050482 

highest scoring ESTs for IFI6:

AA233266 AK024814 AU077025 BC011601 BC015603 BE887546 BG336311 BG435732 BG477513 BG481063 

Unigene Cluster for IFI6:

Interferon, alpha-inducible protein 6
Hs.523847  [show with all ESTs]
Unigene Representative Sequence: BM458012


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IFI6

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1:                          -                           
SP2:                    -     -                           
SP3:                                                      

About this scheme

ECgene alternative splicing isoforms for IFI6

5 Ensembl transcripts including schematic representations:
ENST00000373959  ENST00000373961  ENST00000362020  ENST00000361157  ENST00000339145  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFI6 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFI6

1 / 2 / 3

3 probe-sets matching IFI6 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1358_s_at2, 3 U95-A 9 1.00 0.94 1.00 1.00 U22970 0.20 1.00 0.72 1

204415_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022873 0.60 1.00 0.82 1

204415_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  IFI6 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CGCCGACGAT

SOURCE GeneReport for Unigene cluster: Hs.523847
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for IFI6 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC4781701   -- similar to interferon induced 6-16 protein isoform more 77.44(n)
70.68(a)
478170  XM_535344.2  XP_535344.1 
chimpanzee
(Pan troglodytes)
G1P31   -- interferon, alpha-inducible protein 99.23(n)
98.46(a)
450178  NM_001009069.1  NP_001009069.1 
cow
(Bos taurus)
IFI61   -- interferon, alpha-inducible protein 6 72.09(n)
65.12(a)
512913  NM_001075588.1  NP_001069056.1 
About this table        Species with no ortholog for IFI6

ENSEMBL Gene Tree for IFI6
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for IFI6 gene
IFI27L22  IFI272  IFI27L12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/66 NCBI SNPs in IFI6 are shown (see all 66 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 24)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs28084301,2
A,C,F,H27864874(-) AGGCTC/TGATTC 3 -- ng517Minor allele frequency- T:0.03EU EA WA NA 560
rs28084261,2
A,C,F,H27872795(-) ctgttC/Tctctg 3 -- ng314Minor allele frequency- T:0.24EU EA WA 418
rs11417461,2
A,C27865456(-) CTCTTC/TTTCCT 3 -- ut31 trp31Minor allele frequency- T:0.00MN 184
rs28084281,2
A,C,F,H,O27868725(-) GGCCAA/GGAACA 3 -- int111Minor allele frequency- G:0.05EU EA WA NA 976
rs109026621,2
A,C,F,H27870981(+) GATCGC/TTGATA 3 -- int116Minor allele frequency- T:0.12EU EA WA NA 1472
rs127321991,2
C,F,H27869059(+) CGTacG/Aagagg 3 -- int18Minor allele frequency- A:0.12EU EA WA NA 632
rs171627221,2
C,F,H27870155(+) ATGCTC/TTTTCC 3 -- int1 trp311Minor allele frequency- T:0.02NA EU EA WA 978
rs28084271,2
C,F,H27869722(-) tcatcT/Cggagc 3 -- int18Minor allele frequency- C:0.04EU EA WA 836
rs66848611,2
C,F,H27871016(+) GCCACT/CTGGGG 3 -- int17Minor allele frequency- C:0.02EU EA WA NA 560
rs28084291,2
A,C,F27865847(-) CTCCAT/CGAAGG 3 -- int13Minor allele frequency- C:0.22NA 140
About this table

HapMap Linkage Disequilibrium images for IFI6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147572

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/16 PubMed articles for IFI6 gene (see all 16 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2537 HGNC: 4054 AceView: G1P3 Ensembl:ENSG00000126709 euGenes: HUgn2537
ECgene: IFI6 H-InvDB: IFI6
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFI6:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for IFI6 Antibodies for IFI6
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFI6 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Antibodies for IFI6

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