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Aliases for IFI6 Gene

Aliases for IFI6 Gene

  • Interferon, Alpha-Inducible Protein 6 2 3
  • G1P3 3 4 6
  • Interferon-Induced Protein 6-16 3 4
  • IFI-6-16 3 4
  • IFI616 3 6
  • Interferon, Alpha-Inducible Protein (Clone IFI-6-16) 2
  • Interferon, Alpha-Inducible Protein Clone IFI-6-16 3
  • Interferon Alpha-Inducible Protein 6 3
  • FAM14C 3
  • 6-16 3

External Ids for IFI6 Gene

Previous HGNC Symbols for IFI6 Gene

  • G1P3

Previous GeneCards Identifiers for IFI6 Gene

  • GC01M027865
  • GC01M027992
  • GC01M026248

Summaries for IFI6 Gene

Entrez Gene Summary for IFI6 Gene

  • This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFI6 Gene

IFI6 (Interferon, Alpha-Inducible Protein 6) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling.

Gene Wiki entry for IFI6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI6 Gene

Genomics for IFI6 Gene

Regulatory Elements for IFI6 Gene

Genomic Location for IFI6 Gene

27,666,061 bp from pter
27,672,218 bp from pter
6,158 bases
Minus strand

Genomic View for IFI6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFI6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI6 Gene

Proteins for IFI6 Gene

  • Protein details for IFI6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 6
    Protein Accession:
    Secondary Accessions:
    • Q13141
    • Q13142
    • Q5VVR2
    • Q5VVR3
    • Q6IE95
    • Q969M8

    Protein attributes for IFI6 Gene

    130 amino acids
    Molecular mass:
    12927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI6 Gene


neXtProt entry for IFI6 Gene

Proteomics data for IFI6 Gene at MOPED

Post-translational modifications for IFI6 Gene

No Post-translational modifications

Other Protein References for IFI6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI6 Gene

Domains for IFI6 Gene

Protein Domains for IFI6 Gene


Graphical View of Domain Structure for InterPro Entry



  • P09912
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI6: view

No data available for Gene Families for IFI6 Gene

Function for IFI6 Gene

Molecular function for IFI6 Gene

UniProtKB/Swiss-Prot Induction: By alpha and beta interferons.

Gene Ontology (GO) - Molecular Function for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15685448
genes like me logo Genes that share ontologies with IFI6: view

Phenotypes for IFI6 Gene

GenomeRNAi human phenotypes for IFI6:
genes like me logo Genes that share phenotypes with IFI6: view

miRNA for IFI6 Gene

miRTarBase miRNAs that target IFI6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFI6 Gene

Localization for IFI6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for IFI6 Gene COMPARTMENTS Subcellular localization image for IFI6 gene
Compartment Confidence
mitochondrion 4
plasma membrane 4
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 15685448
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI6: view

Pathways for IFI6 Gene

genes like me logo Genes that share pathways with IFI6: view

Pathways by source for IFI6 Gene

1 GeneGo (Thomson Reuters) pathway for IFI6 Gene

Gene Ontology (GO) - Biological Process for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IMP 15685448
GO:0006955 immune response TAS 3017706
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 15685448
GO:0051902 negative regulation of mitochondrial depolarization IMP 15685448
genes like me logo Genes that share ontologies with IFI6: view

Transcripts for IFI6 Gene

Unigene Clusters for IFI6 Gene

Interferon, alpha-inducible protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFI6 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for IFI6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI6 Gene

mRNA expression in normal human tissues for IFI6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI6 Gene

This gene is overexpressed in Pituitary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFI6 Gene

SOURCE GeneReport for Unigene cluster for IFI6 Gene Hs.523847

genes like me logo Genes that share expressions with IFI6: view

No data available for mRNA Expression by UniProt/SwissProt for IFI6 Gene

Orthologs for IFI6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFI6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI6 35
  • 99.23 (n)
  • 98.46 (a)
IFI6 36
  • 98 (a)
(Bos Taurus)
Mammalia IFI6 35
  • 72.09 (n)
  • 65.12 (a)
IFI6 36
  • 60 (a)
(Canis familiaris)
Mammalia IFI6 35
  • 78.2 (n)
  • 71.43 (a)
IFI6 36
  • 69 (a)
(Monodelphis domestica)
Mammalia IFI6 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia IFI6 36
  • 39 (a)
Species with no ortholog for IFI6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFI6 Gene

Gene Tree for IFI6 (if available)
Gene Tree for IFI6 (if available)

Paralogs for IFI6 Gene

Selected SIMAP similar genes for IFI6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFI6: view

No data available for Paralogs for IFI6 Gene

Variants for IFI6 Gene

Sequence variations from dbSNP and Humsavar for IFI6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1141739 -- 27,668,533(-) CAGGT(A/G)AGAAA reference, missense
rs1141746 -- 27,666,358(-) CTCTT(C/T)TTCCT utr-variant-3-prime
rs1141747 -- 27,666,351(-) TCCTT(C/T)TTGGC utr-variant-3-prime
rs1316895 -- 27,669,592(-) GCGGA(C/G)CTTAC intron-variant
rs1316896 -- 27,669,591(-) CGGAG(C/G)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFI6 Gene

Variant ID Type Subtype PubMed ID
nsv522842 CNV Gain 19592680
esv2745763 CNV Deletion 23290073
esv2745774 CNV Deletion 23290073
esv2745785 CNV Deletion 23290073

Relevant External Links for IFI6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI6 Gene

Disorders for IFI6 Gene

Relevant External Links for IFI6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFI6: view

No data available for UniProtKB/Swiss-Prot for IFI6 Gene

Publications for IFI6 Gene

  1. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PMID: 15685448) Tahara E. Jr. … Tahara E. (Cancer Immunol. Immunother. 2005) 3 23
  2. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. (PMID: 17823654) Cheriyath V. … Borden E.C. (J. Clin. Invest. 2007) 3 23
  3. Characterization of a human gene inducible by alpha- and beta- interferons and its expression in mouse cells. (PMID: 3017706) Kelly J.M. … Kerr I.M. (EMBO J. 1986) 3 4
  4. Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript. (PMID: 7596809) Turri M.G. … Porter A.C.G. (Nucleic Acids Res. 1995) 3 4
  5. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N. … Porter A.C.G. (BMC Genomics 2004) 3 4

Products for IFI6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFI6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFI6
    • Block miRNA regulation of IFI6 using miScript Target Protectors

    Sources for IFI6 Gene

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