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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFI6 Gene

protein-coding GIFtS: 53
GCID: GC01M027992

interferon, alpha-inducible protein 6

(Previous names: interferon, alpha-inducible protein (clone IFI-6-16) )
(Previous symbol: G1P3)

Explore 5 diseases affiliated with
IFI6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 6¹ ²		Interferon-Induced Protein 6-16² ³
G1P3¹ ² ³ ⁵		Interferon, Alpha-Inducible Protein (Clone IFI-6-16)¹
IFI616¹ ² ⁵		Interferon Alpha-Inducible Protein 6²
6-16¹ ²		Interferon, Alpha-Inducible Protein Clone IFI-6-16²
FAM14C¹ ²		Ifi-6-16³
IFI-6-16¹ ²

External Ids:	HGNC: 4054¹	Entrez Gene: 2537²	Ensembl: ENSG00000126709⁷	OMIM: 147572⁵	UniProtKB: P09912³

Export aliases for IFI6 gene to outside databases

Previous GC identifers: GC01M027865 GC01M026248

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFI6:

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical

role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element

resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced

transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have

been described. (provided by RefSeq, Jul 2008)

Gene Wiki entry for IFI6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFI6 gene promoter:
Ik-2 STAT3 PPAR-gamma2 IRF-1 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFI6 promoter sequence

Search SABiosciences Chromatin IP Primers for IFI6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p35

IFI6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI6 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M027992: view genomic region (about GC identifiers)

Start:	27,992,572 bp from pter	End:	27,998,729 bp from pter
Size:	6,158 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912 (See protein sequence)

Recommended Name: Interferon alpha-inducible protein 6 precursor

Size: 130 amino acids; 12927 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8

Alternative splicing: 3 isoforms: P09912-1 P09912-2 P09912-3

Explore the universe of human proteins at neXtProt for IFI6: NX_P09912

IFI6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_002029.3 NP_075010.1 NP_075011.1

ENSEMBL proteins:

ENSP00000354736 ENSP00000342513 ENSP00000355152

Reactome Protein details: P09912
Human Recombinant Protein Products:

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	Novus Biologicals IFI6 Protein Novus Biologicals IFI6 Lysates
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	Uscn Proteins for IFI6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	15685448
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

IFI6 for ontologies About GeneDecksing

IFI6 Antibody Products:

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	Uscn ELISAs and CLIAs for IFI6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFI6 for domains About GeneDecksing

1 InterPro domain/family:

IPR009311 Interferon-induced_6-16

Graphical View of Domain Structure for InterPro Entry P09912

ProtoNet protein and cluster: P09912

1 Blocks protein family: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912

Similarity: Belongs to the IFI6/IFI27 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IFI6_HUMAN, P09912

Induction: By alpha and beta interferons

miRNA Products:		OriGene 3'-UTR Clone (see all 3): IFI6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFI6
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		SwitchGear 3'UTR luciferase reporter plasmid: IFI6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFI6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFI6
		Search LifeMap BioReagents cell lines for IFI6

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFI6

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15685448

IFI6 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for IFI6:

Increased cell death HMECs cel

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Expression of IFN-induced genes

Expression of IFN-induced genes

1.00

Interferon alpha/beta signaling

0.61

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Regulation of IFNA signaling

Immune response_IFN alpha/beta signaling pathway

0.71

Immune response IFN alpha/beta signaling pathway

0.71

Immune System

Immune System

1.00

Type II interferon signaling (IFNG)

Type II interferon signaling (IFNG)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IFI6

Immune response IFN alpha/beta signaling pathway

1 GeneGo (Thomson Reuters) Pathway for IFI6

Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFI6

Type II interferon signaling (IFNG)

5 Reactome Pathways for IFI6

	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Expression of IFN-induced genes
	Interferon Signaling
	Immune System

IFI6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFI6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for IFI6 (P09912³ ENSP00000342513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CIB1	Q99828³, ENSP00000333873⁴	I2D: score=1 STRING: ENSP00000333873
ADAR	ENSP00000357459⁴	STRING: ENSP00000357459
ENSG00000206435	ENSP00000372975⁴	STRING: ENSP00000372975
ENSG00000228299	ENSP00000397867⁴	STRING: ENSP00000397867
ENSG00000235657	ENSP00000388526⁴	STRING: ENSP00000388526

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001836	release of cytochrome c from mitochondria	IMP	15685448
GO:0006955	immune response	TAS	3017706
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0043066	negative regulation of apoptotic process	IMP	15685448
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	15685448

IFI6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFI6
Search CenterWatch for drugs/clinical trials and news about IFI6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFI6 gene (3 alternative transcripts):

NM_002038.3 NM_022872.2 NM_022873.2

Unigene Clusters for IFI6:

Interferon, alpha-inducible protein 6

Hs.523847 [show with all ESTs], Hs.730125 [show with all ESTs]

Unigene Representative Sequences: BM458012, DB152637

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361157(uc001bon.1 uc001boo.1 uc001bop.1) ENST00000339145

ENST00000362020

miRNA Products:		OriGene 3'-UTR Clone (see all 3): IFI6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFI6
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI6

Additional cDNA sequence:

AB164057.1 AB306177.1 AF326334.1 AF387742.1 AF387745.1 AF387746.1 AF387747.1 AF387748.1

AF387749.1 AF387753.1 AF387755.1 AF387756.1 AF387758.1 AF387762.1 AF395520.1 AF395521.1

AF395522.1 AF395527.1 AF395528.1 AF395529.1 AF395530.1 AF397441.1 AF397442.1 AF397443.1

AF397444.1 AF397446.1 AF430686.1 AF430687.1 AF430688.1 AF430692.1 AF430695.1 AF430697.1

AY006112.1 AY006307.1 AY029331.1 AY032920.1 AY032921.1 AY124783.1 AY124785.1 AY124787.1

AY124788.1 AY124794.1 AY124795.1 AY190096.1 AY751838.1 AY751864.1 HM467880.1 L06890.1

M64353.1 M73466.1 M90475.1 X51795.1 X58809.1 X74850.1 X86104.1 X86105.1

X86106.1 X86110.1 X86137.1 X92885.1 Y15203.1 Z77845.1

24/35 DOTS entries (see all 35):

DT.75133179 DT.91920762 DT.95135143 DT.91963304 DT.98084055 DT.100766780 DT.95166405 DT.121330646

DT.121076203 DT.95166424 DT.99927243 DT.100642481 DT.100032309 DT.100824648 DT.121075869 DT.92456573

DT.100032301 DT.100756449 DT.100778969 DT.100824649 DT.102841081 DT.121076536 DT.121076626 DT.121076903

24/247 AceView cDNA sequences (see all 247):

BM354146 AA075262 Z20822 BQ083495 AI277855 AI873959 BQ083787 CB124292

AI521538 CB112693 BT006850 BM142149 CB151563 BM263192 N27839 D56126

AA367248 BQ083980 AA075776 CD671420 AA075171 BU542092 AA029363 AW778890

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IFI6 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b
SP1:									-
SP2:							-		-
SP3:

ECgene alternative splicing isoforms for IFI6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFI6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCGACGAT

About this image

IFI6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IFI6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFI6

SOURCE GeneReport for Unigene clusters: Hs.523847 Hs.730125

SABiosciences Expression via Pathway-Focused PCR Arrays including IFI6:

Interferons & Receptors in human mouse rat

Type I Interferon Response in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFI6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI6

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFI6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFI6 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IFI27L2⁶	putative ISG12-1 protein	36(a)	1 → many	23(4661933-4665616)
lizard (Anolis carolinensis)	Reptilia	-- --	--	49(a) 20(a)	possible ortholog possible ortholog	GL343498.1(96838-99481) GL343558.1(288340-297430)
zebrafish (Danio rerio)	Actinopterygii	zgc:152791⁶ zgc:123068⁶ (see all 8)	zgc:123068 (see all 8)	44(a) 42(a) (see all 8)	possible ortholog possible ortholog (see all 8)	13(38014818-38017588) 13(38003194-38005739)

ENSEMBL Gene Tree for IFI6 (if available)
TreeFam Gene Tree for IFI6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFI6 gene

IFI27L2² IFI27² IFI27L1²

3 SIMAP similar genes for IFI6 using alignment to 1 protein entry: IFI6_HUMAN:

IFI27L2 IFI27 IFI27L1

IFI6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187840366^1,2		--	27992088(+)	`TTGCCA/GAGCCC`	3	--	ds500¹		0	--	--	--	--
rs56898115^1,2	F,	--	27992112(+)	`GTTACG/ACCCTT`	3	--	ds500¹		1		EA	120
rs2808430^1,2	C,F,A,H,	--	27992287(-)	`AGGCTC/TGATTC`	3	--	ds500¹		25		NS EA NA WA CSA	1703
rs80002722^1,2	C,F,	--	27992398(+)	`TCTGAA/CGGCAT`	3	--	ds500¹		1		WA	118
rs192164202^1,2		--	27992479(+)	`GACTCA/GAGGGG`	3	--	ds500¹		0	--	--	--	--
rs79329207^1,2	C,F,	--	27992624(+)	`GGGGAG/AAGTGA`	3	--	ut3¹		4		CSA WA	123
rs182625575^1,2		--	27992659(+)	`ATCGTC/TGGCGC`	3	--	ut3¹		0	--	--	--	--
rs145877801^1,2		--	27992662(+)	`GTCGGC/TGCATG`	3	--	ut3¹		0	--	--	--	--
rs148998579^1,2		--	27992709(+)	`CACTTA/GAGGCT`	3	--	ut3¹		0	--	--	--	--
rs187700106^1,2		--	27992741(+)	`ACTATA/GTTCGC`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFI6 (27992572 - 27998729 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFI6: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFI6

DNA2.0 Custom Variant and Variant Library Synthesis for IFI6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFI6 for disorders           About GeneDecksing

OMIM gene information: 147572    OMIM disorders: --

5 diseases for IFI6:    About MalaCards

hepatitis b ovarian cancer gastric cancer myeloma

hepatitis

Human Genome Epidemiology (HuGE) Navigator: IFI6 (2 documents)

Export disorders for IFI6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFI6 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with IFI6)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)^{1, 2} Parker N. and Porter A.C.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript. (PubMed id 7596809)^{1, 2} Turri M.G.... Porter A.C.G. (1995)
Characterization of a human gene inducible by alpha- and beta- interferons and its expression in mouse cells. (PubMed id 3017706)^{1, 2} Kelly J.M....Kerr I.M. (1986)
G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. (PubMed id 17823654)^{1, 9} Cheriyath V....Borden E.C. (2007)
G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PubMed id 15685448)^{1, 9} Tahara E. Jr.... Tahara E. (2005)
G1P3, an interferon- and estrogen-induced survival pro tein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breas t cancer. (PubMed id 21996729)¹ Cheriyath V....Borden E.C. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)¹ Johnatty S.E.... . (2010)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2537	HGNC: 4054	AceView: G1P3	Ensembl:ENSG00000126709	euGenes: HUgn2537
ECgene: IFI6	H-InvDB: IFI6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFI6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFI6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFI6 gene:
Search GeneIP for patents involving IFI6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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IFI6 Gene

interferon, alpha-inducible protein 6

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IFI6 Gene

interferon, alpha-inducible protein 6

Aliasesfor IFI6 gene

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Genomic Viewsfor IFI6 gene

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Protein Domains /Familiesfor IFI6 gene

Functionfor IFI6 gene

Pathways & Interactionsfor IFI6 gene

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Expression for IFI6 gene

Orthologsfor IFI6 gene

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Disorders / Diseasesfor IFI6 gene

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Specialized Databases showing IFI6 gene

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for IFI6 gene

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for IFI6 gene

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for IFI6 gene

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for IFI6 gene

Protein Domains /
Families
for IFI6 gene

Function
for IFI6 gene

Pathways & Interactions
for IFI6 gene

Drugs & Compounds
for IFI6 gene

Transcripts
for IFI6 gene

Expression
for IFI6 gene

Orthologs
for IFI6 gene

Paralogs
for IFI6 gene

Genomic Variants
for IFI6 gene

Disorders / Diseases
for IFI6 gene

Publications
for IFI6 gene

Intellectual Property
for IFI6 gene

Products
for IFI6 gene