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Aliases for IFI44L Gene

Aliases for IFI44L Gene

  • Interferon Induced Protein 44 Like 2 3 5
  • Interferon-Induced Protein 44-Like 2 3
  • C1orf29 3 4
  • Chromosome 1 Open Reading Frame 29 2
  • GS3686 3

External Ids for IFI44L Gene

Previous HGNC Symbols for IFI44L Gene

  • C1orf29

Previous GeneCards Identifiers for IFI44L Gene

  • GC01P078799
  • GC01P078858
  • GC01P079085
  • GC01P077217

Summaries for IFI44L Gene

GeneCards Summary for IFI44L Gene

IFI44L (Interferon Induced Protein 44 Like) is a Protein Coding gene. An important paralog of this gene is IFI44.

UniProtKB/Swiss-Prot for IFI44L Gene

  • Exhibits a low antiviral activity against hepatitis C virus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44L Gene

Genomics for IFI44L Gene

Regulatory Elements for IFI44L Gene

Enhancers for IFI44L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F078617 1.1 Ensembl ENCODE 0.8 -2.2 -2164 0.5 GTF2F1 CTCF MXI1 SIN3A MAX RAD21 RFX5 YY1 ZNF143 SMC3 IFI44L PIR50856
GH01F078619 0.5 ENCODE 0.8 +1.0 1030 3.8 TBP PKNOX1 WRNIP1 ZNF384 RELA ZNF366 POLR2A STAT2 EED NFE2 IFI44 IFI44L
GH01F078623 0.5 Ensembl 0.8 +4.0 3979 0.6 WRNIP1 NBN MLLT1 MAFK IFI44 IFI44L
GH01F078645 0.6 Ensembl 0.3 +26.0 25979 1.4 NSRP1P1 IFI44 IFI44L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFI44L on UCSC Golden Path with GeneCards custom track

Promoters for IFI44L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001746688 1378 3400 TBP PKNOX1 WRNIP1 ZNF384 RELA ZNF366 POLR2A STAT2 EED ETV6

Genomic Location for IFI44L Gene

Chromosome:
1
Start:
78,619,922 bp from pter
End:
78,646,145 bp from pter
Size:
26,224 bases
Orientation:
Plus strand

Genomic View for IFI44L Gene

Genes around IFI44L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44L Gene

Proteins for IFI44L Gene

  • Protein details for IFI44L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53G44-IF44L_HUMAN
    Recommended name:
    Interferon-induced protein 44-like
    Protein Accession:
    Q53G44
    Secondary Accessions:
    • Q86TE1
    • Q96B64
    • Q99984

    Protein attributes for IFI44L Gene

    Size:
    452 amino acids
    Molecular mass:
    51322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA19056.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAD96807.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI44L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44L Gene

Post-translational modifications for IFI44L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI44L Gene

Domains & Families for IFI44L Gene

Protein Domains for IFI44L Gene

Graphical View of Domain Structure for InterPro Entry

Q53G44

UniProtKB/Swiss-Prot:

IF44L_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44L: view

No data available for Gene Families for IFI44L Gene

Function for IFI44L Gene

Molecular function for IFI44L Gene

UniProtKB/Swiss-Prot Function:
Exhibits a low antiviral activity against hepatitis C virus.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Gene Ontology (GO) - Molecular Function for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IFI44L: view
genes like me logo Genes that share phenotypes with IFI44L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI44L Gene

Localization for IFI44L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI44L Gene COMPARTMENTS Subcellular localization image for IFI44L gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44L: view

Pathways & Interactions for IFI44L Gene

SuperPathways for IFI44L Gene

No Data Available

Interacting Proteins for IFI44L Gene

Selected Interacting proteins: Q53G44-IF44L_HUMAN for IFI44L Gene via IID

Gene Ontology (GO) - Biological Process for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with IFI44L: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44L Gene

Transcripts for IFI44L Gene

Unigene Clusters for IFI44L Gene

Interferon-induced protein 44-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: -
SP11: - -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IFI44L Gene

GeneLoc Exon Structure for
IFI44L
ECgene alternative splicing isoforms for
IFI44L

Expression for IFI44L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI44L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44L Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI44L Gene



Protein tissue co-expression partners for IFI44L Gene

NURSA nuclear receptor signaling pathways regulating expression of IFI44L Gene:

IFI44L

SOURCE GeneReport for Unigene cluster for IFI44L Gene:

Hs.744918
genes like me logo Genes that share expression patterns with IFI44L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFI44L Gene

Orthologs for IFI44L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI44L 34 35
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia IFI44L 34 35
  • 77.7 (n)
dog
(Canis familiaris)
Mammalia IFI44L 34 35
  • 73.7 (n)
rat
(Rattus norvegicus)
Mammalia Ifi44l 34
  • 68.56 (n)
mouse
(Mus musculus)
Mammalia Ifi44l 34 16 35
  • 65.98 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR855320.1 35
  • 36 (a)
ManyToMany
zgc:153654 35
  • 34 (a)
ManyToMany
si:ch211-197g15.8 35
  • 33 (a)
ManyToMany
si:ch211-197g15.9 35
  • 33 (a)
ManyToMany
si:dkey-193b15.5 35
  • 33 (a)
ManyToMany
si:ch211-197g15.6 35 35
  • 31 (a)
ManyToMany
si:ch211-197g15.7 35
  • 31 (a)
ManyToMany
si:ch211-197g15.10 35
  • 30 (a)
ManyToMany
si:dkey-79f11.7 35
  • 28 (a)
ManyToMany
si:dkeyp-9d4.2 35
  • 28 (a)
ManyToMany
si:ch211-208g24.8 35
  • 27 (a)
ManyToMany
si:dkey-79f11.5 35
  • 27 (a)
ManyToMany
si:dkey-79f11.9 35
  • 27 (a)
ManyToMany
CABZ01073795.1 35
  • 26 (a)
ManyToMany
si:dkey-79f11.4 35
  • 26 (a)
ManyToMany
CABZ01045230.1 35
  • 25 (a)
ManyToMany
si:dkey-79f11.10 35
  • 25 (a)
ManyToMany
si:dkey-79f11.8 35
  • 25 (a)
ManyToMany
si:dkeyp-75b4.9 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for IFI44L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44L Gene

ENSEMBL:
Gene Tree for IFI44L (if available)
TreeFam:
Gene Tree for IFI44L (if available)

Paralogs for IFI44L Gene

Paralogs for IFI44L Gene

(1) SIMAP similar genes for IFI44L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44L: view

Variants for IFI44L Gene

Sequence variations from dbSNP and Humsavar for IFI44L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1057920 -- 78,646,006(+) TGGAG(A/G)TGGGG utr-variant-3-prime
rs111233009 -- 78,635,086(+) CTTTT(G/T)TAATT intron-variant
rs111248026 -- 78,646,149(+) AAGCC(A/G)CTGAG downstream-variant-500B
rs111336413 -- 78,645,522(+) GATAG(A/G)GGGGC utr-variant-3-prime
rs111489894 -- 78,642,384(+) ACTGC(-/A/AAAA)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFI44L Gene

Variant ID Type Subtype PubMed ID
esv2661424 CNV deletion 23128226
esv2750218 CNV deletion 23290073
esv3303563 CNV mobile element insertion 20981092
esv3309841 CNV mobile element insertion 20981092
esv3386975 CNV insertion 20981092
esv3406252 CNV insertion 20981092
esv3431836 CNV insertion 20981092
esv3586552 CNV loss 21293372
nsv1001291 CNV loss 25217958
nsv830315 CNV gain 17160897

Variation tolerance for IFI44L Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI44L Gene

Human Gene Mutation Database (HGMD)
IFI44L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44L Gene

Disorders for IFI44L Gene

Relevant External Links for IFI44L

Human Genome Epidemiology (HuGE) Navigator
IFI44L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI44L

No disorders were found for IFI44L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44L Gene

Publications for IFI44L Gene

  1. Differential regulation of NF-I_B-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. (PMID: 25620704) Sauter D. … Kirchhoff F. (Cell Rep 2015) 3 64
  2. Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. (PMID: 26116899) Zahoor M.A. … Aida Y. (Virus Res. 2015) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. (PMID: 24755989) Bloch D.B. … Yang W. (PLoS ONE 2014) 3 64
  5. HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. (PMID: 25170834) Zahoor M.A. … Aida Y. (PLoS ONE 2014) 3 64

Products for IFI44L Gene

Sources for IFI44L Gene

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