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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFI44L Gene

protein-coding   GIFtS: 47
GCID: GC01P079085

Interferon-Induced Protein 44-Like

(Previous name: chromosome 1 open reading frame 29)
(Previous symbol: C1orf29)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon-Induced Protein 44-Like1 2
C1orf291 2 3
Chromosome 1 Open Reading Frame 291

External Ids:    HGNC: 178171   Entrez Gene: 109642   Ensembl: ENSG000001379597   OMIM: 6139755   UniProtKB: Q53G443   

Export aliases for IFI44L gene to outside databases

Previous GC identifers: GC01P078799 GC01P078858 GC01P077217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFI44L Gene: 
IFI44L (interferon-induced protein 44-like) is a protein-coding gene. Diseases associated with IFI44L include chikungunya, and hepatitis c. An important paralog of this gene is IFI44.

UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44
Function: Exhibits a low antiviral activity against hepatitis C virus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFI44L gene promoter:
         C/EBPbeta   LHX3b/Lhx3b   POU2F1   POU2F1b   POU2F1a   LHX3a/Lhx3a   POU2F1c   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI44L promoter sequence
   Search SABiosciences Chromatin IP Primers for IFI44L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI44L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p22.3

IFI44L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI44L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P079085:  view genomic region     (about GC identifiers)

Start:
79,085,607 bp from pter      End:
79,111,830 bp from pter
Size:
26,224 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 (See protein sequence)
Recommended Name: Interferon-induced protein 44-like  
Size: 452 amino acids; 51322 Da
Subcellular location: Cytoplasm (Potential)
Sequence caution: Sequence=AAH15932.1; Type=Erroneous initiation; Sequence=BAA19056.1; Type=Frameshift;
Positions=18; Sequence=BAD96807.1; Type=Erroneous initiation;
Secondary accessions: Q86TE1 Q96B64 Q99984
Alternative splicing: 2 isoforms:  Q53G44-1   Q53G44-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IFI44L: NX_Q53G44

Explore proteomics data for IFI44L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53G44

  • IFI44L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFI44L Protein Expression
    REFSEQ proteins: NP_006811.2  
    ENSEMBL proteins: 
     ENSP00000409914   ENSP00000359787   ENSP00000400784   ENSP00000342833  

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    Cloud-Clone Corp. Proteins for IFI44L 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    IFI44L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024644 IFI44_fam
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q53G44

    ProtoNet protein and cluster: Q53G44

    UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44
    Similarity: Belongs to the IFI44 family


    IFI44L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF44L_HUMAN, Q53G44
    Function: Exhibits a low antiviral activity against hepatitis C virus
    Induction: By type I interferons

    Phenotypes:
         1 GenomeRNAi human phenotype for IFI44L:

     Increased G1 DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidIFI44L 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFI44L

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0051607defense response to virus IEA--

    IFI44L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFI44L (IF44L)

    Search CenterWatch for drugs/clinical trials and news about IFI44L / IF44L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFI44L gene: 
    NM_006820.2  

    Unigene Cluster for IFI44L:

    Interferon-induced protein 44-like
    Hs.744918  [show with all ESTs]
    Unigene Representative Sequence: NM_006820
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452835 ENST00000476521 ENST00000370751(uc010oro.2 uc010orp.2 uc010orq.2)
    ENST00000459784 ENST00000476876 ENST00000486882 ENST00000462041 ENST00000450498
    ENST00000474002 ENST00000494910 ENST00000342282
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate IFI44L:
    hsa-miR-1304 hsa-miR-4254 hsa-miR-205 hsa-miR-450b-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidIFI44L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFI44L
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI44L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI44L

    Additional mRNA sequence: 

    AB000115.1 AB116553.1 AK223087.1 AK225442.1 AK293385.1 AK303187.1 AK312272.1 AK316232.1 
    BC015932.2 

    10 DOTS entries:

    DT.445654  DT.453257  DT.453504  DT.40115865  DT.92019283  DT.92422988  DT.91844010  DT.100845192 
    DT.91688882  DT.75114227 

    24/115 AceView cDNA sequences (see all 115):

    F10462 AA913818 AA243416 AI342415 CA390015 BU616973 BM904203 CD106974 
    CA423461 AI686888 BU517170 AI422859 BQ219494 AI051147 AW193245 BX501650 
    BU856905 AA410188 BC015932 AA303544 AI282423 F12860 AI682015 AA938694 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                            -     -     -     -                             -                       -                                       
    SP2:                                            -     -     -     -     -     -     -           -                       -     -                                 
    SP3:                                                                                            -                       -                                       
    SP4:                                            -     -     -     -     -     -     -           -                       -                                       
    SP5:                                            -     -     -     -     -     -     -           -                       -     -                                 

    ExUns: 12a · 12b ^ 13a · 13b · 13c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for IFI44L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFI44L expression in normal human tissues (normalized intensities)      IFI44L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFI44L Expression
    About this image


    IFI44L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             ganglion/cranial/facial VII   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor EN7
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             clps   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             Human Skeletal Muscle Cells (HSkMC)   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor

    See IFI44L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFI44L

    SOURCE GeneReport for Unigene cluster: Hs.744918
        SABiosciences Expression via Pathway-Focused PCR Array including IFI44L: 
              Interferons & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI44L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFI44L gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifi44l1 , 5 histocompatibility 285
    interferon-induced protein 44 like1
    65.82(n)1
    53.1(a)1
      3 (76.94 cM)5
    150611  NM_031367.11  NP_112735.11 
     1517596415 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    53(a)
    42(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343194.1(5115588-5115764)
    GL343194.1(5168586-5175593)
    zebrafish
    (Danio rerio)
    Actinopterygii CR855320.16
    zgc:1536546
    (see all 20)
    zgc:153654
    (see all 20)
    36(a)
    33(a)
    (see all 20)
    possible ortholog
    possible ortholog
    (see all 20)
    1(6928646-6930673)
    2(36634957-36639542)


    ENSEMBL Gene Tree for IFI44L (if available)
    TreeFam Gene Tree for IFI44L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFI44L gene
    IFI442  
    1 SIMAP similar gene for IFI44L using alignment to 4 protein entries:     IF44L_HUMAN (see all proteins):
    IFI44

    IFI44L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/674 SNPs in IFI44L are shown (see all 674)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749147921,2
    C,F--79084115(+) GTGACA/GGTTCC 1 -- us2k11Minor allele frequency- G:0.07EA 120
    rs1931983981,2
    --79084129(+) GTCTTC/TCCTTG 1 -- us2k10--------
    rs1855051601,2
    --79084149(+) ATCTTC/GACACT 1 -- us2k10--------
    rs1907574731,2
    --79084189(+) ATGTCC/TTTCAG 1 -- us2k10--------
    rs2732391,2
    C--79084289(-) caggtA/Gcccca 1 -- us2k15Minor allele frequency- G:0.08NA WA EA 362
    rs1430090361,2
    --79084332(+) TTGATC/TGTTTA 1 -- us2k10--------
    rs1475650721,2
    C--79084380(+) TACTG-/TTTTTT 1 -- us2k10--------
    rs1474742091,2
    --79084633(+) ATATCA/GGTATA 1 -- us2k10--------
    rs1925928421,2
    --79084699(+) AAATTC/GTTCGG 1 -- us2k10--------
    rs1158978211,2
    C,F--79084703(+) TGTTCG/AGCTTT 1 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for IFI44L (79085607 - 79111830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IFI44L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661424CNV Deletion23128226
    esv2750218CNV Deletion23290073
    esv274113CNV Insertion20981092
    esv267842CNV Insertion20981092
    nsv871140CNV Gain21882294
    nsv830315CNV Gain17160897
    nsv871835CNV Gain21882294


    Human Gene Mutation Database (HGMD): IFI44L
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFI44L
    DNA2.0 Custom Variant and Variant Library Synthesis for IFI44L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613975    OMIM disorders: --

    4 diseases for IFI44L:    About MalaCards
    chikungunya    hepatitis c    hepatitis    hepatitis b


    IFI44L for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: IFI44L (1 document)

    Export disorders for IFI44L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFI44L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IFI44L)
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    1. Identification of risk loci with shared effects on fiv e major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1  ....Sullivan P.F. (2013)
    2. A diverse range of gene products are effectors of the type I interferon antiviral response. (PubMed id 21478870)2 Schoggins J.W.... Rice C.M. (2011)
    3. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10964 HGNC: 17817 AceView: C1orf29 Ensembl:ENSG00000137959 euGenes: HUgn10964
    ECgene: IFI44L H-InvDB: IFI44L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFI44L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFI44L gene:
    Search GeneIP for patents involving IFI44L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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