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Aliases for IFI44L Gene

Aliases for IFI44L Gene

  • Interferon-Induced Protein 44-Like 2 3
  • C1orf29 3 4
  • Chromosome 1 Open Reading Frame 29 2
  • GS3686 3

External Ids for IFI44L Gene

Previous HGNC Symbols for IFI44L Gene

  • C1orf29

Previous GeneCards Identifiers for IFI44L Gene

  • GC01P078799
  • GC01P078858
  • GC01P079085
  • GC01P077217

Summaries for IFI44L Gene

GeneCards Summary for IFI44L Gene

IFI44L (Interferon-Induced Protein 44-Like) is a Protein Coding gene. An important paralog of this gene is IFI44.

UniProtKB/Swiss-Prot for IFI44L Gene

  • Exhibits a low antiviral activity against hepatitis C virus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44L Gene

Genomics for IFI44L Gene

Regulatory Elements for IFI44L Gene

Genomic Location for IFI44L Gene

Chromosome:
1
Start:
78,619,922 bp from pter
End:
78,646,145 bp from pter
Size:
26,224 bases
Orientation:
Plus strand

Genomic View for IFI44L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFI44L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44L Gene

Proteins for IFI44L Gene

  • Protein details for IFI44L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53G44-IF44L_HUMAN
    Recommended name:
    Interferon-induced protein 44-like
    Protein Accession:
    Q53G44
    Secondary Accessions:
    • Q86TE1
    • Q96B64
    • Q99984

    Protein attributes for IFI44L Gene

    Size:
    452 amino acids
    Molecular mass:
    51322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA19056.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAD96807.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI44L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44L Gene

Proteomics data for IFI44L Gene at MOPED

Post-translational modifications for IFI44L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI44L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI44L Gene

Domains & Families for IFI44L Gene

Protein Domains for IFI44L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q53G44

UniProtKB/Swiss-Prot:

IF44L_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44L: view

No data available for Gene Families for IFI44L Gene

Function for IFI44L Gene

Molecular function for IFI44L Gene

UniProtKB/Swiss-Prot Function:
Exhibits a low antiviral activity against hepatitis C virus.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Phenotypes for IFI44L Gene

genes like me logo Genes that share phenotypes with IFI44L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI44L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI44L Gene

Localization for IFI44L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI44L Gene COMPARTMENTS Subcellular localization image for IFI44L gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44L: view

Pathways & Interactions for IFI44L Gene

SuperPathways for IFI44L Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Interferons & Receptors in human,mouse,rat

Interacting Proteins for IFI44L Gene

Gene Ontology (GO) - Biological Process for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with IFI44L: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44L Gene

Drugs & Compounds for IFI44L Gene

No Compound Related Data Available

Transcripts for IFI44L Gene

Unigene Clusters for IFI44L Gene

Interferon-induced protein 44-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI44L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: -
SP11: - -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IFI44L Gene

GeneLoc Exon Structure for
IFI44L
ECgene alternative splicing isoforms for
IFI44L

Expression for IFI44L Gene

mRNA expression in normal human tissues for IFI44L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44L Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI44L Gene



SOURCE GeneReport for Unigene cluster for IFI44L Gene Hs.744918

genes like me logo Genes that share expression patterns with IFI44L: view

Protein tissue co-expression partners for IFI44L Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFI44L Gene

Orthologs for IFI44L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFI44L 35
  • 77.7 (n)
  • 64.16 (a)
IFI44L 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFI44L 35
  • 73.7 (n)
  • 58.72 (a)
IFI44L 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifi44l 35
  • 65.98 (n)
  • 53.1 (a)
Ifi44l 16
Ifi44l 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFI44L 35
  • 98.82 (n)
  • 97.79 (a)
IFI44L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifi44l 35
  • 68.56 (n)
  • 54.67 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01045230.1 36
  • 25 (a)
ManyToMany
CABZ01073795.1 36
  • 26 (a)
ManyToMany
CR855320.1 36
  • 36 (a)
ManyToMany
si:ch211-197g15.10 36
  • 30 (a)
ManyToMany
si:ch211-197g15.6 36
  • 31 (a)
ManyToMany
si:ch211-197g15.6 36
  • 32 (a)
ManyToMany
si:ch211-197g15.7 36
  • 31 (a)
ManyToMany
si:ch211-197g15.8 36
  • 33 (a)
ManyToMany
si:ch211-197g15.9 36
  • 33 (a)
ManyToMany
si:ch211-208g24.8 36
  • 27 (a)
ManyToMany
si:dkey-193b15.5 36
  • 33 (a)
ManyToMany
si:dkey-79f11.10 36
  • 25 (a)
ManyToMany
si:dkey-79f11.4 36
  • 26 (a)
ManyToMany
si:dkey-79f11.5 36
  • 27 (a)
ManyToMany
si:dkey-79f11.7 36
  • 28 (a)
ManyToMany
si:dkey-79f11.8 36
  • 25 (a)
ManyToMany
si:dkey-79f11.9 36
  • 27 (a)
ManyToMany
si:dkeyp-75b4.9 36
  • 25 (a)
ManyToMany
si:dkeyp-9d4.2 36
  • 28 (a)
ManyToMany
zgc:153654 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for IFI44L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44L Gene

ENSEMBL:
Gene Tree for IFI44L (if available)
TreeFam:
Gene Tree for IFI44L (if available)

Paralogs for IFI44L Gene

Paralogs for IFI44L Gene

(1) SIMAP similar genes for IFI44L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44L: view

Variants for IFI44L Gene

Sequence variations from dbSNP and Humsavar for IFI44L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13029 -- 78,642,306(+) CCAAC(A/G)TCACA utr-variant-3-prime
rs166642 -- 78,643,930(-) AACCA(A/G)CTTGC utr-variant-3-prime
rs273239 -- 78,618,604(-) caggt(A/G)cccca upstream-variant-2KB
rs273240 -- 78,620,478(-) CTTAA(C/G)AGATC utr-variant-5-prime, upstream-variant-2KB
rs273241 -- 78,620,785(-) AACAG(G/T)TTAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFI44L Gene

Variant ID Type Subtype PubMed ID
nsv871835 CNV Gain 21882294
nsv830315 CNV Gain 17160897
esv2750218 CNV Deletion 23290073
esv2661424 CNV Deletion 23128226
nsv871140 CNV Gain 21882294
esv274113 CNV Insertion 20981092
esv267842 CNV Insertion 20981092

Variation tolerance for IFI44L Gene

Residual Variation Intolerance Score: 92.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI44L Gene

HapMap Linkage Disequilibrium report
IFI44L
Human Gene Mutation Database (HGMD)
IFI44L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44L Gene

Disorders for IFI44L Gene

Relevant External Links for IFI44L

Human Genome Epidemiology (HuGE) Navigator
IFI44L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI44L
genes like me logo Genes that share disorders with IFI44L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44L Gene

Publications for IFI44L Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Differential regulation of NF-I_B-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. (PMID: 25620704) Sauter D. … Kirchhoff F. (Cell Rep 2015) 67
  3. Common variants associated with general and MMR vaccine-related febrile seizures. (PMID: 25344690) Feenstra B. … Hviid A. (Nat. Genet. 2014) 67
  4. HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. (PMID: 25170834) Zahoor M.A. … Aida Y. (PLoS ONE 2014) 67
  5. LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. (PMID: 24755989) Bloch D.B. … Yang W. (PLoS ONE 2014) 67

Products for IFI44L Gene

Sources for IFI44L Gene

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