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IFI44L Gene

protein-coding GIFtS: 43

GC01P078858

interferon-induced protein 44-like
(Previous name: chromosome 1 open reading frame 29 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C1orf29)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C1orf29 ^², ³
GS3686 ^¹, ²

Descriptions
chromosome 1 open reading frame 29 ^¹
interferon-induced protein 44-like ^²

External Ids
HGNC: 17817¹
Entrez Gene: 10964²
UniProtKB: Q53G44³
Ensembl: ENSG00000137959⁷

Search outside databases for aliases for IFI44L gene

Previous GC identifer: GC01P078799

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFI44L gene

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p22.3

IFI44L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P078858: (about GC identifiers)

Start:	78,858,676 bp from pter
End:	78,881,072 bp from pter
Size:	22,397 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 (See protein sequence)

Recommended Name: Interferon-induced protein 44-like

Size: 452 amino acids; 51322 Da

Subcellular location: Cytoplasm (Potential)

Sequence caution: Sequence=BAA19056.1; Type=Frameshift; Positions=18;

Secondary accessions: Q86TE1 Q96B64 Q99984

Alternative splicing: 2 isoforms: Q53G44-1 Q53G44-2

REFSEQ proteins: NP_006811.2

ENSEMBL proteins:

ENSP00000342833 ENSP00000359787

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (IFI44L)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for IFI44L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IFI44L
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (IFI44L)
	Novus Biologicals Antibody for IFI44L

Assays for IFI44L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q53G44

UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44

Similarity: Belongs to the IFI44 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI44L)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFI44L)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006820

Applied Biosystems Silencer® siRNAs for IFI44L

Sigma-Aldrich siRNA for IFI44L

Sigma-Aldrich shRNA for IFI44L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFI44L
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006820
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006820
untagged cDNA clones in CMV expression vector (see all 3): NM_006820

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006820

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFI44L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI44L)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFI44L)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006820

Sigma-Aldrich siRNA for IFI44L

Sigma-Aldrich shRNA for IFI44L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006820

REFSEQ mRNAs for IFI44L gene:

NM_006820.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006820

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006820
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006820
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006820

Additional cDNA sequence:

AB000115.1 AB116553.1 AK223087.1 AK225442.1 AK293385.1 AK303187.1 AK312272.1 AK316232.1

BC015932.2

11 DOTS entries:

DT.445654 DT.453257 DT.92019283 DT.453504 DT.40115865 DT.92422988 DT.91844010 DT.100845192

DT.102824906 DT.75114227 DT.91688882

24/115 AceView cDNA sequences (see all 115 ):

AI682015 F12860 AA243416 AI422859 AA913818 CA423461 BU616973 CD106974

BU856905 BM904203 AI686888 AI342415 AA303544 CA390015 BQ219494 AI282423

F10462 AW193245 AI361921 AA410188 BX501650 AI051147 AA938694 BC015932

highest scoring ESTs for IFI44L:

AB000115 AA033845 AA088869 AA193287 AA194233 AA410188 AA410567 AA515349 AA570374 AA740459

Unigene Cluster for IFI44L:

Interferon-induced protein 44-like

Hs.389724 [show with all ESTs]

Unigene Representative Sequence: NM_006820

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L (see all 12 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^
SP1:															-		-		-		-										-								-
SP2:															-		-		-		-		-		-		-				-								-		-
SP3:																															-								-
SP4:															-		-		-		-		-		-		-				-								-
SP5:															-		-		-		-		-		-		-				-								-		-

ExUns:	12a	·	12b	^	13a	·	13b	·	13c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IFI44L

2 Ensembl transcripts including schematic representations:

ENST00000342282 ENST00000370751

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFI44L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFI44L

¹ / ² / ³

7 probe-sets matching IFI44L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36927_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.95	AB000115	1.00	1.00	1.00	1
55001_at²	U95-C	1	1.00	1.00	0.99	1.06	--	--	--	--	--
62288_at²	U95-C	1	0.69	1.00	0.93	1.00	--	--	--	--	--
204439_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006820	0.60	1.00	0.82	1
214059_at*²	U133-A	3	1.00	0.33	--	--	--	--	--	--	--
204439_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214059_at*²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

GeneDecks IFI44L for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.389724
Expression variation in blood from EXPOLDB for IFI44L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IFI44L gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFI44L¹	--	interferon-induced protein 44-like	73.35(n) 56.64(a)	479980 XM_537104.2 XP_537104.2
chimpanzee (Pan troglodytes)	IFI44L¹	--	interferon-induced protein 44-like	98.87(n) 97.82(a)	469362 XM_001169723.1 XP_001169723.1
rat (Rattus norvegicus)	H28¹	--	histocompatibility 28	68.33(n) 54.36(a)	310968 XM_227820.4 XP_227820.4
mouse (Mus musculus)	H28^{1, 5}	3 (82.50 cM)⁵	histocompatibility 28^{1, 5}	65.4(n)¹ 52.78(a)¹	15061¹ NM_031367.1¹ NP_112735.1¹ AF336221⁵ BC024930⁵

About this table Species with no ortholog for IFI44L

ENSEMBL Gene Tree for IFI44L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFI44L gene

IFI44²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/128 NCBI SNPs in IFI44L are shown (see all 128 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs987495^1,2	A,C,F,H,O	78868169(-)	`TGGTGA/GTATCA`	1	I/T	mis¹ ese³		20	EA NA MN EU WA	3050
	rs273259^1,2	A,C,F,H,O	78866406(-)	`TTTCAC/TGTAAA`	1	H/R	mis¹ ese³		18	EA NA EU WA	1368
	rs166642^1,2	A,C,F,H	78882203(-)	`aaccaG/Acttgc`	1	--	ut3¹		8	EU EA WA	840
	rs273258^1,2	C,F,H,O	78866630(-)	`CTGACA/GGTGGC`	1	R/C	mis¹ ese³		21	MN NA EA EU WA	1808
	rs3820093^1,2	A,C,F,H	78868114(-)	`CTTGAC/TTGAAT`	1	V/I	mis¹ ese³		12	NA EU EA WA	1048
	rs2148686^1,2	A,C,F,H	78884007(-)	`TTAATC/ATACTG`	1	--	ut3¹		8	EU EA WA	840
	rs1333972^1,2	C,F,H,O	78883730(-)	`TGTGAT/GAGTCT`	1	--	ut3¹		12	EA NA EU WA	1054
	rs4650590^1,2	A,C,F,H	78883106(+)	`TGTCAG/ATGCTA`	1	--	ut3¹		6	EU EA NA	440
	rs273240^1,2	C,F,H	78858751(-)	`CTTAAG/CAGATC`	1	--	ut5¹ ese³		9	EU EA WA NA MN	1814
	rs1981071^1,2	C,F,H	78875314(-)	`TTTACG/AGGAAT`	1	C/R	mis¹ ese³		14	MN EU EA WA NA	1456

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HapMap Linkage Disequilibrium images for IFI44L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for IFI44L gene:

The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10964	HGNC: 17817	AceView: C1orf29	Ensembl:ENSG00000137959	euGenes: HUgn10964
ECgene: IFI44L	H-InvDB: IFI44L

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for IFI44L
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFI44L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFI44L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFI44L		Antibodies for IFI44L
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFI44L		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IFI44L)
	Antibodies (IFI44L)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for IFI44L

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IFI44L Gene at Home site.
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IFI44L Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for IFI44L

Summaries
for IFI44L

Genomic Location
for IFI44L

Proteins
for IFI44L

Protein Domains/
Families
for IFI44L

Gene Function
for IFI44L

Pathways & Interactions
for IFI44L

Drugs & Compounds
for IFI44L

Transcripts
for IFI44L

Expression
for IFI44L

Orthologs
for IFI44L

Paralogs
for IFI44L

SNPs/Variants
for IFI44L

Disorders & Mutations
for IFI44L

Medical News
for IFI44L

Publications
for IFI44L

Search for IFI44L

Genome Databases showing IFI44L

Other Databases showing IFI44L

Specialized Databases showing IFI44L

Licensable Technologies
for IFI44L

Services
for IFI44L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFI44L Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor IFI44L

Summariesfor IFI44L

Genomic Locationfor IFI44L

Proteinsfor IFI44L

Protein Domains/Familiesfor IFI44L

Gene Functionfor IFI44L

Pathways & Interactionsfor IFI44L

Drugs & Compoundsfor IFI44L

Transcriptsfor IFI44L

Expression for IFI44L

Orthologsfor IFI44L

Paralogsfor IFI44L

SNPs/Variantsfor IFI44L

Disorders & Mutationsfor IFI44L

Medical Newsfor IFI44L

Publicationsfor IFI44L

Search for IFI44L

Genome Databases showing IFI44L

Other Databases showing IFI44L

Specialized Databases showing IFI44L

Licensable Technologiesfor IFI44L

Servicesfor IFI44L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFI44L

Summaries
for IFI44L

Genomic Location
for IFI44L

Proteins
for IFI44L

Protein Domains/
Families
for IFI44L

Gene Function
for IFI44L

Pathways & Interactions
for IFI44L

Drugs & Compounds
for IFI44L

Transcripts
for IFI44L

Expression
for IFI44L

Orthologs
for IFI44L

Paralogs
for IFI44L

SNPs/Variants
for IFI44L

Disorders & Mutations
for IFI44L

Medical News
for IFI44L

Publications
for IFI44L

Licensable Technologies
for IFI44L

Services
for IFI44L