IFI44L Gene
protein-coding GIFtS : 47
GCID: GC01 P079085
interferon-induced protein 44-like (Previous name: chromosome 1 open reading frame 29 ) (Previous symbol: C1orf29 )
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Aliasesfor IFI44L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Interferon-Induced Protein 44-Like 1 2 C1orf291 2 3 GS36861 Chromosome 1 Open Reading Frame 291
Export aliases for IFI44L gene to outside databases Previous GC identifers: GC01P078799 GC01P078858 GC01P077217
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Summariesfor IFI44L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 Function : Exhibits a low antiviral activity against hepatitis C virus
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Genomic Viewsfor IFI44L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IFI44L gene promoter: C/EBPbeta LHX3b/Lhx3b POU2F1 POU2F1b POU2F1a LHX3a/Lhx3a POU2F1c Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for IFI44L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI44L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p22.3 IFI44L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P079085: view genomic region
(about GC identifiers )
Start:
79,085,607 bp from pter
End:
79,111,830 bp from pter
Size:
26,224 bases
Orientation:
plus strand
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Proteinsfor IFI44L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 (See
protein sequence )Recommended Name: Interferon-induced protein 44-like Size : 452 amino acids; 51322 Da
Subcellular location : Cytoplasm (Potential)
Sequence caution : Sequence=AAH15932.1; Type=Erroneous initiation; Sequence=BAA19056.1; Type=Frameshift; Positions=18;Sequence=BAD96807.1; Type=Erroneous initiation;
Secondary accessions : Q86TE1 Q96B64 Q99984Alternative splicing : 2 isoforms : Q53G44-1 Q53G44-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IFI44L: NX_Q53G44 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q53G44 IFI44L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_006811.2 ENSEMBL proteins: ENSP00000409914 ENSP00000359787 ENSP00000400784 ENSP00000342833 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
IFI44L for ontologies About GeneDecksing IFI44L Antibody Products: Assay Products for IFI44L:
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Protein
Domains / Familiesfor IFI44L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IFI44L for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q53G44 ProtoNet protein and cluster: Q53G44
UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 Similarity : Belongs to the IFI44 family
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Functionfor IFI44L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: IF44L_HUMAN, Q53G44 Function : Exhibits a low antiviral activity against hepatitis C virusInduction : By type I interferons
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IFI44L (NM_006820 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFI44L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFI44L
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI44L
1 GenomeRNAi human phenotype for IFI44L :
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Pathways & Interactionsfor IFI44L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFI44L Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
IFI44L for ontologies About GeneDecksing
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Drugs & Compoundsfor IFI44L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IFI44L Search CenterWatch for drugs/clinical trials and news about IFI44L / IF44L
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Transcriptsfor IFI44L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IFI44L gene: NM_006820.2 Unigene Cluster for IFI44L:
Interferon-induced protein 44-like Hs.389724 [show with all ESTs ] Unigene Representative Sequence: NM_006820 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000452835 ENST00000476521 ENST00000370751 (uc010oro.2 uc010orp.2 uc010orq.2 )ENST00000459784 ENST00000476876 ENST00000486882 ENST00000462041 ENST00000450498 ENST00000474002 ENST00000494910 ENST00000342282 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IFI44L (NM_006820 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFI44L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFI44L
Additional cDNA sequence: AB000115.1 AB116553.1 AK223087.1 AK225442.1 AK293385.1 AK303187.1 AK312272.1 AK316232.1 BC015932.2
10 DOTS entries : DT.445654 DT.453257
DT.453504 DT.92019283 DT.40115865 DT.92422988 DT.91844010 DT.100845192 DT.91688882 DT.75114227 24/115 AceView cDNA sequences (see all 115 ):
AI361921 BQ219494 CD106974 BU616973 AI051147 AI422859 AI342415 AI282423 AA243416 CA390015 AI686888 F10462 CA423461 AW193245 BU856905 BC015932 AI682015 AA303544 AA913818 F12860 BX501650 AA938694 BM904203 BU517170 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L (see all 12 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ SP1 :               -   -   -   -           -         -               SP2 :               -   -   -   -   -   -   -     -         -   -             SP3 :                               -         -               SP4 :               -   -   -   -   -   -   -     -         -               SP5 :               -   -   -   -   -   -   -     -         -   -            
ExUns: 12a · 12b ^ 13a · 13b · 13c SP1 :           SP2 :           SP3 :           SP4 :           SP5 :          
ECgene alternative splicing isoforms for IFI44L
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Expression for IFI44L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IFI44L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image IFI44L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See IFI44L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IFI44L SOURCE GeneReport for Unigene cluster: Hs.389724 SABiosciences Expression via Pathway-Focused PCR Array including IFI44L : Interferons & Receptors in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFI44LBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IFI44L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFI44L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFI44L In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI44L
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Orthologsfor IFI44L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IFI44L gene from 2/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for IFI44L (if available)TreeFam Gene Tree for IFI44L (if available)
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Paralogsfor IFI44L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IFI44L gene IFI44 2 1 SIMAP similar gene for IFI44L using alignment to 4 protein entries: IF44L_HUMAN (see all proteins ):IFI44
IFI44L for paralogs About GeneDecksing
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Genomic Variantsfor IFI44L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IFI44L (79085607 - 79111830 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for IFI44L 1 CNV : 4231 Human Gene Mutation Database (HGMD) : IFI44L SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFI44L
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Disorders
/ Diseasesfor IFI44L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IFI44L for disorders About GeneDecksing
OMIM gene information: 613975
OMIM disorders : --4 diseases for IFI44L : About MalaCards chikungunya hepatitis c hepatitis b hepatitis Human Genome Epidemiology (HuGE) Navigator: IFI44L (1 document)Export disorders for IFI44L gene to outside databases
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Publicationsfor IFI44L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IFI44L gene integrated from 9 sources : (articles sorted by number of sources associating them with IFI44L) Utopia : connect your pdf to the dynamic world of online information
A diverse range of gene products are effectors of the type I interferon antiviral response. (PubMed id 21478870) 2 Schoggins J.W.... Rice C.M. (2011) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994)
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External Searches for IFI44L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IFI44L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IFI44L gene
(According to HUGE )
About This Section --
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Specialized Databases showing IFI44L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IFI44L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IFI44L gene: Search GeneIP for patents involving IFI44L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IFI44L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IFI44L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IFI44L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFI44L Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IFI44L OriGene 3'-UTR Clone for IFI44L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFI44L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IFI44L OriGene Custom Protein Services for IFI44L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFI44L QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFI44L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI44L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IFI44L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFI44L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFI44L
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IFI44L Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI44L
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFI44L
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Aliases for IFI44L
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