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IFI44 Gene

protein-coding GIFtS: 51

GC01P078888

interferon-induced protein 44
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MTAP44 ^¹, ², ³
OTTHUMP00000011293 ^²
P44 ^⁵
p44 ^¹, ², ³

Descriptions
Microtubule-associated protein 44 ^³
interferon-induced protein 44 ^²
interferon-induced, hepatitis C-associated microtubular aggregate protein ^²
interferon-induced, hepatitis C-associated microtubular aggregate protein (44kD) ^²

External Ids
HGNC: 16938¹
Entrez Gene: 10561²
UniProtKB: Q8TCB0³
Ensembl: ENSG00000137965⁷

Search outside databases for aliases for IFI44 gene

Previous GC identifers: GC01P079275 GC01P078014 GC01P078506 GC01P078538 GC01P078827

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IFI44_HUMAN, Q8TCB0

Function: This protein aggregates to form microtubular structures (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFI44 gene

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1

IFI44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P078888: (about GC identifiers)

Start:	78,888,104 bp from pter
End:	78,902,345 bp from pter
Size:	14,242 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFI44_HUMAN, Q8TCB0 (See protein sequence)

Recommended Name: Interferon-induced protein 44

Size: 444 amino acids; 50491 Da

Subcellular location: Cytoplasm (Potential)

Secondary accessions: Q14496

REFSEQ proteins: NP_006408.3

ENSEMBL proteins:

ENSP00000359783

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFI44)
	Human Recombinant Proteins from Abnova (IFI44)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for IFI44:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IFI44
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFI44), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFI44)
	Novus Biologicals Antibody for IFI44

Assays for IFI44:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8TCB0

UniProtKB/Swiss-Prot: IFI44_HUMAN, Q8TCB0

Similarity: Belongs to the IFI44 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI44)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006417

Applied Biosystems Silencer® siRNAs for IFI44

Sigma-Aldrich siRNA for IFI44

Sigma-Aldrich shRNA for IFI44

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006417
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006417
untagged cDNA clone in CMV expression vector: NM_006417

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006417

UniProtKB/Swiss-Prot: IFI44_HUMAN, Q8TCB0

Function: This protein aggregates to form microtubular structures (By similarity)

Induction: By alpha and beta interferons, but not by gamma interferons

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for IFI44 (ENSP00000359783³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	ENSP00000369552³	STRING (score=.745)
--	ENSP00000351672³	STRING (score=.71)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFI44

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI44)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006417

Sigma-Aldrich siRNA for IFI44

Sigma-Aldrich shRNA for IFI44

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006417

REFSEQ mRNAs for IFI44 gene:

NM_006417.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006417

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006417
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006417
                                 untagged cDNA clone in CMV expression vector: NM_006417

Additional cDNA sequence:

AK302527.1 AK316278.1 AK316476.1 BC022870.1 BX537508.1 CR621445.1

12 DOTS entries:

DT.444841 DT.100714496 DT.121412969 DT.95370300 DT.100025567 DT.100790776 DT.95303647 DT.100025569

DT.121412952 DT.92428028 DT.95370299 DT.121412962

24/116 AceView cDNA sequences (see all 116 ):

AA480136 AI472619 BQ437856 AW204634 CA426666 CB151546 AI275105 CA423905

AI086345 BG661331 AI290106 BU167907 BQ772889 BE049439 C05190 AA464178

CR621445 AI358603 BM547313 BQ775060 BX645196 AA476356 AA476308 AA948069

highest scoring ESTs for IFI44:

AA182891 AA233648 AA441899 AA464178 AA476308 AA775662 AA948069 AA975121 AI086345 AI160736

Unigene Cluster for IFI44:

Interferon-induced protein 44

Hs.82316 [show with all ESTs]

Unigene Representative Sequence: BX537508

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IFI44 (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c
SP1:																											-
SP2:					-
SP3:					-		-																-		-		-
SP4:					-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for IFI44

1 Ensembl transcript including schematic representation:

ENST00000370747

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFI44 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFI44

¹ / ² / ³

5 probe-sets matching IFI44 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37641_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D28915	0.20	1.00	0.72	1
214453_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006417	0.60	1.00	0.82	1
214059_at*²^{, 3}	U133-A	3	1.00	0.33	--	--	BE049439	0.60	1.00	0.82	1
214453_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214059_at*²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

GeneDecks IFI44 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTTAGTCAT

SOURCE GeneReport for Unigene cluster: Hs.82316
Expression variation in blood from EXPOLDB for IFI44

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFI44 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFI44¹	--	interferon-induced protein 44	75(n) 59.58(a)	490198 XM_547319.2 XP_547319.2
chimpanzee (Pan troglodytes)	IFI44¹	--	interferon-induced protein 44	98.57(n) 97.52(a)	456971 XM_513514.2 XP_513514.2
cow (Bos taurus)	IFI44¹	--	interferon-induced protein 44	75.91(n) 60.9(a)	508348 XM_872122.2 XP_877215.2
rat (Rattus norvegicus)	Ifi44¹	--	interferon-induced protein 44	68.65(n) 54.76(a)	310969 XM_227821.4 XP_227821.4
mouse (Mus musculus)	Ifi44^{1, 5}	3⁵	interferon-induced protein 44^{1, 5}	69.84(n)¹ 57.14(a)¹	99899¹ NM_133871.1¹ NP_598632.1¹ AA967902⁵ AJ299405⁵ (see all 18)

About this table Species with no ortholog for IFI44

ENSEMBL Gene Tree for IFI44

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFI44 gene

IFI44L²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/67 NCBI SNPs in IFI44 are shown (see all 67 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs273250^1,2	A,C,F,H	78887894(-)	`TCACTG/AACTTT`	1	--	ng5¹		11		EA NA WA EU	868
	rs2070123^1,2	C,F,H	78888493(+)	`TGACAT/CGGTTG`	1	R/W	mis¹		20		NS EA NA EU WA	2718
	rs10493610^1,2	C,F,H	78887082(+)	`CTTTCC/TTGATT`	1	--	ng5¹		12		NS EU EA WA NA	666
	rs12025679^1,2	A,H	78886838(+)	`tgatgC/Tgaact`	1	--	ng5¹		4		EU EA WA	416
	rs1051047^1,2	C	78902282(+)	`AAATAA/GTAATA`	1	--	ut3¹		0	--	--	--	--
	rs35851276^1,2	F	78898912(-)	`ACAGGC/TTCACA`	1	E/E	syn¹		1		NA	78
	rs3766325^1,2	A,C,F,H	78901502(-)	`AATGCC/TAATCC`	1	--	int¹		12		EA EU WA NA	2466
	rs11577395^1,2	A,C,F,H	78900908(+)	`CTTTCA/GTAATT`	1	--	int¹		4		EU EA WA	406
	rs7514391^1,2	A,C,F,H	78895682(+)	`TTTCTA/GTGTGT`	1	--	int¹		4		EU EA WA	418
	rs11577132^1,2	C,F,H	78891821(+)	`GCATCG/ACTTAT`	1	--	int¹		7		NA EU EA WA	558

About this table

HapMap Linkage Disequilibrium images for IFI44 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 610468

1 Novoseek disease relationship for IFI44 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis delta	72.20	1	7925411 (1)

About this table

Human Genome Epidemiology Navigator: IFI44 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/11 PubMed articles for IFI44 gene (see all 11 ):

Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. (PubMed id 7925411)^{1, 2, 3, 4} Kitamura A.... Kitamura N. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PubMed id 16886895)^{1, 3} Hwang Y....Chen D.S. (2006)
Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PubMed id 18953482)³ Mailaparambil B....Heinzmann A. (2008)
Antiproliferative activity of the human IFN-alpha-inducible protein IFI44. (PubMed id 17784819)³ Hallen L.C....Foser S. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)³ Izmailova E....Aldovini A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Gene-gene and gene-environment interactions in interferon therapy for chronic hepatitis C. (PubMed id 17979507)¹ Lin E....Chen E.Y. (2007)
Cloning, sequencing and expression in Escherichia coli of cDNA for a non-A, non-B hepatitis-associated microtubular aggregates protein. (PubMed id 2170570)¹ Takahashi K....Yamada E. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10561	HGNC: 16938	AceView: IFI44	Ensembl:ENSG00000137965	euGenes: HUgn10561
ECgene: IFI44	H-InvDB: IFI44

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFI44
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFI44:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFI44-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFI44		Antibodies for IFI44
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFI44		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for IFI44

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IFI44 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for IFI44

Summaries
for IFI44

Genomic Location
for IFI44

Proteins
for IFI44

Protein Domains/
Families
for IFI44

Gene Function
for IFI44

Pathways & Interactions
for IFI44

Drugs & Compounds
for IFI44

Transcripts
for IFI44

Expression
for IFI44

Orthologs
for IFI44

Paralogs
for IFI44

SNPs/Variants
for IFI44

Disorders & Mutations
for IFI44

Medical News
for IFI44

Publications
for IFI44

Search for IFI44

Genome Databases showing IFI44

Other Databases showing IFI44

Specialized Databases showing IFI44

Licensable Technologies
for IFI44

Services
for IFI44

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFI44 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor IFI44

Summariesfor IFI44

Genomic Locationfor IFI44

Proteinsfor IFI44

Protein Domains/Familiesfor IFI44

Gene Functionfor IFI44

Pathways & Interactionsfor IFI44

Drugs & Compoundsfor IFI44

Transcriptsfor IFI44

Expression for IFI44

Orthologsfor IFI44

Paralogsfor IFI44

SNPs/Variantsfor IFI44

Disorders & Mutationsfor IFI44

Medical Newsfor IFI44

Publicationsfor IFI44

Search for IFI44

Genome Databases showing IFI44

Other Databases showing IFI44

Specialized Databases showing IFI44

Licensable Technologiesfor IFI44

Servicesfor IFI44

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFI44

Summaries
for IFI44

Genomic Location
for IFI44

Proteins
for IFI44

Protein Domains/
Families
for IFI44

Gene Function
for IFI44

Pathways & Interactions
for IFI44

Drugs & Compounds
for IFI44

Transcripts
for IFI44

Expression
for IFI44

Orthologs
for IFI44

Paralogs
for IFI44

SNPs/Variants
for IFI44

Disorders & Mutations
for IFI44

Medical News
for IFI44

Publications
for IFI44

Licensable Technologies
for IFI44

Services
for IFI44