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Aliases for IFI44 Gene

Aliases for IFI44 Gene

  • Interferon Induced Protein 44 2 3 5
  • TBC/LysM-Associated Domain Containing 5 2 3
  • Microtubule-Associated Protein 44 3 4
  • MTAP44 3 4
  • P44 3 4
  • Interferon-Induced, Hepatitis C-Associated Microtubular Aggregate Protein (44kD) 3
  • Interferon-Induced Protein 44 2
  • TLDC5 3

External Ids for IFI44 Gene

Previous GeneCards Identifiers for IFI44 Gene

  • GC01P079275
  • GC01P078014
  • GC01P078506
  • GC01P078538
  • GC01P078827
  • GC01P078888
  • GC01P079115
  • GC01P077247

Summaries for IFI44 Gene

GeneCards Summary for IFI44 Gene

IFI44 (Interferon Induced Protein 44) is a Protein Coding gene. An important paralog of this gene is IFI44L.

UniProtKB/Swiss-Prot for IFI44 Gene

  • This protein aggregates to form microtubular structures.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44 Gene

Genomics for IFI44 Gene

Regulatory Elements for IFI44 Gene

Enhancers for IFI44 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFI44 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFI44 Gene

Chromosome:
1
Start:
78,648,943 bp from pter
End:
78,664,078 bp from pter
Size:
15,136 bases
Orientation:
Plus strand

Genomic View for IFI44 Gene

Genes around IFI44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44 Gene

Proteins for IFI44 Gene

  • Protein details for IFI44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB0-IFI44_HUMAN
    Recommended name:
    Interferon-induced protein 44
    Protein Accession:
    Q8TCB0
    Secondary Accessions:
    • B7ZAG3
    • D3DQ80
    • Q14496

    Protein attributes for IFI44 Gene

    Size:
    444 amino acids
    Molecular mass:
    50491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44 Gene

Proteomics data for IFI44 Gene at MOPED

Post-translational modifications for IFI44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI44 Gene

Domains & Families for IFI44 Gene

Protein Domains for IFI44 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFI44 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCB0

UniProtKB/Swiss-Prot:

IFI44_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44: view

No data available for Gene Families for IFI44 Gene

Function for IFI44 Gene

Molecular function for IFI44 Gene

UniProtKB/Swiss-Prot Function:
This protein aggregates to form microtubular structures.
UniProtKB/Swiss-Prot Induction:
By alpha and beta interferons, but not by gamma interferons.
genes like me logo Genes that share phenotypes with IFI44: view

Animal Models for IFI44 Gene

MGI Knock Outs for IFI44:

Animal Model Products

miRNA for IFI44 Gene

miRTarBase miRNAs that target IFI44

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFI44 Gene

Localization for IFI44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI44 Gene COMPARTMENTS Subcellular localization image for IFI44 gene
Compartment Confidence
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for IFI44 Gene

Pathways & Interactions for IFI44 Gene

SuperPathways for IFI44 Gene

No Data Available

Interacting Proteins for IFI44 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359783%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359783 for IFI44 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for IFI44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFI44 Gene

Drugs & Compounds for IFI44 Gene

No Compound Related Data Available

Transcripts for IFI44 Gene

Unigene Clusters for IFI44 Gene

Interferon-induced protein 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3: - - - - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for IFI44 Gene

GeneLoc Exon Structure for
IFI44
ECgene alternative splicing isoforms for
IFI44

Expression for IFI44 Gene

mRNA expression in normal human tissues for IFI44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44 Gene

This gene is overexpressed in NK cells (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for IFI44 Gene



SOURCE GeneReport for Unigene cluster for IFI44 Gene Hs.82316

genes like me logo Genes that share expression patterns with IFI44: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFI44 Gene

Orthologs for IFI44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFI44 35
  • 75.91 (n)
  • 61.14 (a)
IFI44 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFI44 35
  • 75.15 (n)
  • 59.26 (a)
IFI44 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifi44 35
  • 69.76 (n)
  • 57.38 (a)
Ifi44 16
Ifi44 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFI44 35
  • 98.72 (n)
  • 97.75 (a)
IFI44 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifi44 35
  • 68.65 (n)
  • 55 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-197g15.6 35
  • 47.82 (n)
  • 39.33 (a)
CABZ01045230.1 36
  • 26 (a)
ManyToMany
CABZ01073795.1 36
  • 30 (a)
ManyToMany
CR855320.1 36
  • 35 (a)
ManyToMany
si:ch211-208g24.8 36
  • 26 (a)
ManyToMany
si:dkey-79f11.10 36
  • 26 (a)
ManyToMany
si:dkey-79f11.4 36
  • 27 (a)
ManyToMany
si:dkey-79f11.5 36
  • 29 (a)
ManyToMany
si:dkey-79f11.7 36
  • 31 (a)
ManyToMany
si:dkey-79f11.8 36
  • 27 (a)
ManyToMany
si:dkey-79f11.9 36
  • 30 (a)
ManyToMany
si:dkeyp-75b4.9 36
  • 26 (a)
ManyToMany
si:dkeyp-9d4.2 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for IFI44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44 Gene

ENSEMBL:
Gene Tree for IFI44 (if available)
TreeFam:
Gene Tree for IFI44 (if available)

Paralogs for IFI44 Gene

Paralogs for IFI44 Gene

(1) SIMAP similar genes for IFI44 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44: view

Variants for IFI44 Gene

Sequence variations from dbSNP and Humsavar for IFI44 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2070123 - 78,650,220(+) TGACA(A/C/T)GGTTG nc-transcript-variant, reference, missense
rs10301 -- 78,663,699(-) AGAGG(A/T)ATATT intron-variant
rs192431 -- 78,660,043(-) ACTCT(A/C)TGCTT intron-variant
rs273247 -- 78,661,209(-) tggca(C/T)gtgcc intron-variant
rs273248 -- 78,659,155(-) ATTAT(A/G)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFI44 Gene

Variant ID Type Subtype PubMed ID
nsv871835 CNV Gain 21882294
nsv830315 CNV Gain 17160897
nsv871140 CNV Gain 21882294
esv2677291 CNV Deletion 23128226

Variation tolerance for IFI44 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFI44 Gene

Disorders for IFI44 Gene

Relevant External Links for IFI44

Genetic Association Database (GAD)
IFI44
Human Genome Epidemiology (HuGE) Navigator
IFI44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI44

No disorders were found for IFI44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44 Gene

Publications for IFI44 Gene

  1. Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. (PMID: 7925411) Kitamura A. … Kitamura N. (Eur. J. Biochem. 1994) 2 3 4 23 67
  2. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 23
  3. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. (PMID: 25776761) Power D. … Zhu J. (Virology 2015) 3
  4. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells. (PMID: 24742347) Kukkonen S. … Aldovini A. (Retrovirology 2014) 3
  5. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3

Products for IFI44 Gene

Sources for IFI44 Gene

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