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Aliases for IFI44 Gene

Aliases for IFI44 Gene

  • Interferon Induced Protein 44 2 3 5
  • TBC/LysM-Associated Domain Containing 5 2 3
  • Microtubule-Associated Protein 44 3 4
  • Interferon-Induced Protein 44 2 3
  • MTAP44 3 4
  • P44 3 4
  • Interferon-Induced, Hepatitis C-Associated Microtubular Aggregate Protein (44kD) 3
  • TLDC5 3

External Ids for IFI44 Gene

Previous GeneCards Identifiers for IFI44 Gene

  • GC01P079275
  • GC01P078014
  • GC01P078506
  • GC01P078538
  • GC01P078827
  • GC01P078888
  • GC01P079115
  • GC01P077247

Summaries for IFI44 Gene

GeneCards Summary for IFI44 Gene

IFI44 (Interferon Induced Protein 44) is a Protein Coding gene. An important paralog of this gene is IFI44L.

UniProtKB/Swiss-Prot for IFI44 Gene

  • This protein aggregates to form microtubular structures.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44 Gene

Genomics for IFI44 Gene

Regulatory Elements for IFI44 Gene

Enhancers for IFI44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F078619 0.5 ENCODE 12.5 -28.0 -27992 3.8 TBP PKNOX1 WRNIP1 ZNF384 RELA ZNF366 POLR2A STAT2 EED NFE2 IFI44 IFI44L
GH01F078623 0.5 Ensembl 12.5 -25.0 -25043 0.6 WRNIP1 NBN MLLT1 MAFK IFI44 IFI44L
GH01F078070 0.7 Ensembl ENCODE 6.3 -577.6 -577595 2.1 PKNOX1 JUN CEBPB JUNB FEZF1 YY1 JUND ATF3 ZNF512 FOS GIPC2 ACTG1P21 MIGA1 RNA5SP21 IFI44 RNU6-1102P LOC100131495
GH01F079040 1.4 FANTOM5 Ensembl 5.3 +391.9 391858 0.8 ZBED1 JUNB FEZF1 ATF2 GABPA OSR2 JUND TCF7 ETV6 CREM ADGRL4 IFI44 PSAT1P3
GH01F077829 0.9 Ensembl ENCODE 5.2 -816.4 -816403 6.5 SIN3A GATA3 PRDM10 NFE2 MAFK EZH2 TCF7L2 NFE2L2 RFX1 NR2F2 RNA5SP21 MIGA1 ACTG1P21 USP33 IFI44 NEXN FUBP1 NSRP1P1 LOC653631
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFI44 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFI44 Gene

Chromosome:
1
Start:
78,648,943 bp from pter
End:
78,664,078 bp from pter
Size:
15,136 bases
Orientation:
Plus strand

Genomic View for IFI44 Gene

Genes around IFI44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44 Gene

Proteins for IFI44 Gene

  • Protein details for IFI44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB0-IFI44_HUMAN
    Recommended name:
    Interferon-induced protein 44
    Protein Accession:
    Q8TCB0
    Secondary Accessions:
    • B7ZAG3
    • D3DQ80
    • Q14496

    Protein attributes for IFI44 Gene

    Size:
    444 amino acids
    Molecular mass:
    50491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44 Gene

Post-translational modifications for IFI44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI44 Gene

No data available for DME Specific Peptides for IFI44 Gene

Domains & Families for IFI44 Gene

Protein Domains for IFI44 Gene

Suggested Antigen Peptide Sequences for IFI44 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCB0

UniProtKB/Swiss-Prot:

IFI44_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44: view

No data available for Gene Families for IFI44 Gene

Function for IFI44 Gene

Molecular function for IFI44 Gene

UniProtKB/Swiss-Prot Function:
This protein aggregates to form microtubular structures.
UniProtKB/Swiss-Prot Induction:
By alpha and beta interferons, but not by gamma interferons.
genes like me logo Genes that share phenotypes with IFI44: view

Animal Models for IFI44 Gene

MGI Knock Outs for IFI44:

Animal Model Products

miRNA for IFI44 Gene

miRTarBase miRNAs that target IFI44

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFI44 Gene

Localization for IFI44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI44 Gene COMPARTMENTS Subcellular localization image for IFI44 gene
Compartment Confidence
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44: view

Pathways & Interactions for IFI44 Gene

SuperPathways for IFI44 Gene

No Data Available

Interacting Proteins for IFI44 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359783%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359783 Q8TCB0-IFI44_HUMAN for IFI44 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus TAS 7925411
genes like me logo Genes that share ontologies with IFI44: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44 Gene

Transcripts for IFI44 Gene

Unigene Clusters for IFI44 Gene

Interferon-induced protein 44:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3: - - - - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for IFI44 Gene

GeneLoc Exon Structure for
IFI44
ECgene alternative splicing isoforms for
IFI44

Expression for IFI44 Gene

mRNA expression in normal human tissues for IFI44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44 Gene

This gene is overexpressed in NK cells (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFI44 Gene



NURSA nuclear receptor signaling pathways regulating expression of IFI44 Gene:

IFI44

SOURCE GeneReport for Unigene cluster for IFI44 Gene:

Hs.82316
genes like me logo Genes that share expression patterns with IFI44: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFI44 Gene

Orthologs for IFI44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI44 34 35
  • 98.72 (n)
cow
(Bos Taurus)
Mammalia IFI44 34 35
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia IFI44 34 35
  • 75.15 (n)
mouse
(Mus musculus)
Mammalia Ifi44 34 16 35
  • 69.76 (n)
rat
(Rattus norvegicus)
Mammalia Ifi44 34
  • 68.65 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-197g15.6 34
  • 47.82 (n)
CR855320.1 35
  • 35 (a)
ManyToMany
si:dkey-79f11.7 35
  • 31 (a)
ManyToMany
CABZ01073795.1 35
  • 30 (a)
ManyToMany
si:dkey-79f11.9 35
  • 30 (a)
ManyToMany
si:dkey-79f11.5 35
  • 29 (a)
ManyToMany
si:dkeyp-9d4.2 35
  • 28 (a)
ManyToMany
si:dkey-79f11.4 35
  • 27 (a)
ManyToMany
si:dkey-79f11.8 35
  • 27 (a)
ManyToMany
CABZ01045230.1 35
  • 26 (a)
ManyToMany
si:ch211-208g24.8 35
  • 26 (a)
ManyToMany
si:dkey-79f11.10 35
  • 26 (a)
ManyToMany
si:dkeyp-75b4.9 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for IFI44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44 Gene

ENSEMBL:
Gene Tree for IFI44 (if available)
TreeFam:
Gene Tree for IFI44 (if available)

Paralogs for IFI44 Gene

Paralogs for IFI44 Gene

(1) SIMAP similar genes for IFI44 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44: view

Variants for IFI44 Gene

Sequence variations from dbSNP and Humsavar for IFI44 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10301 -- 78,663,699(-) AGAGG(A/T)ATATT intron-variant
rs10493610 -- 78,648,809(+) CTTTC(C/T)TGATT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1051030 -- 78,655,089(+) ATTCT(A/C/G)CTGCT nc-transcript-variant, reference, synonymous-codon
rs1051031 -- 78,655,092(+) CTGCT(C/G)CTGGG nc-transcript-variant, reference, synonymous-codon
rs1051045 -- 78,663,877(+) AAAAC(A/C)CAGAC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFI44 Gene

Variant ID Type Subtype PubMed ID
esv2677291 CNV deletion 23128226
esv3586554 CNV loss 21293372
nsv1001291 CNV loss 25217958
nsv830315 CNV gain 17160897

Variation tolerance for IFI44 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44 Gene

Disorders for IFI44 Gene

Relevant External Links for IFI44

Genetic Association Database (GAD)
IFI44
Human Genome Epidemiology (HuGE) Navigator
IFI44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI44

No disorders were found for IFI44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44 Gene

Publications for IFI44 Gene

  1. Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. (PMID: 7925411) Kitamura A. … Kitamura N. (Eur. J. Biochem. 1994) 2 3 4 22 64
  2. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 22 46 64
  3. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PMID: 18953482) Mailaparambil B. … Heinzmann A. (Arch. Virol. 2008) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. (PMID: 25776761) Power D. … Zhu J. (Virology 2015) 3 64

Products for IFI44 Gene

Sources for IFI44 Gene

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