Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFI35 Gene

Aliases for IFI35 Gene

  • Interferon-Induced Protein 35 2 3
  • IFP 35 3 4
  • Ifi-35 3 4
  • IFP35 3 4
  • Interferon-Induced 35 KDa Protein 3

External Ids for IFI35 Gene

Previous GeneCards Identifiers for IFI35 Gene

  • GC17M062367
  • GC17P043320
  • GC17P041067
  • GC17P041532
  • GC17P041533
  • GC17P038412
  • GC17P041158
  • GC17P036924

Summaries for IFI35 Gene

GeneCards Summary for IFI35 Gene

IFI35 (Interferon-Induced Protein 35) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. An important paralog of this gene is NMI.

UniProtKB/Swiss-Prot for IFI35 Gene

  • Not yet known

Gene Wiki entry for IFI35 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI35 Gene

Genomics for IFI35 Gene

Regulatory Elements for IFI35 Gene

Genomic Location for IFI35 Gene

43,006,725 bp from pter
43,014,459 bp from pter
7,735 bases
Plus strand

Genomic View for IFI35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFI35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI35 Gene

Proteins for IFI35 Gene

  • Protein details for IFI35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-induced 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • C9JGX1
    • Q92984
    • Q99537
    • Q9BV98

    Protein attributes for IFI35 Gene

    286 amino acids
    Molecular mass:
    31546 Da
    Quaternary structure:
    • Homodimer. Also interacts with B-ATF
    • Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI35 Gene


neXtProt entry for IFI35 Gene

Proteomics data for IFI35 Gene at MOPED

Post-translational modifications for IFI35 Gene

  • Ubiquitination at Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for IFI35 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFI35 Gene

Domains for IFI35 Gene

Protein Domains for IFI35 Gene


Suggested Antigen Peptide Sequences for IFI35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P80217
  • Belongs to the NMI family.
genes like me logo Genes that share domains with IFI35: view

No data available for Gene Families for IFI35 Gene

Function for IFI35 Gene

Molecular function for IFI35 Gene

GENATLAS Biochemistry: interferon-induced leucine zipper protein IFI35,may be the same as APRF
UniProtKB/Swiss-Prot Function: Not yet known
UniProtKB/Swiss-Prot Induction: By interferon gamma

Gene Ontology (GO) - Molecular Function for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18624398
genes like me logo Genes that share ontologies with IFI35: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI35

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFI35 Gene

Localization for IFI35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI35 Gene

Nucleus. Note=Nuclear following IFN treatment.

Subcellular locations from

Jensen Localization Image for IFI35 Gene COMPARTMENTS Subcellular localization image for IFI35 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8288566
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFI35: view

Pathways for IFI35 Gene

genes like me logo Genes that share pathways with IFI35: view

Pathways by source for IFI35 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with IFI35: view

Compounds for IFI35 Gene

(1) Novoseek inferred chemical compound relationships for IFI35 Gene

Compound -log(P) Hits PubMed IDs
leucine 58.5 6
genes like me logo Genes that share compounds with IFI35: view

Transcripts for IFI35 Gene

Unigene Clusters for IFI35 Gene

Interferon-induced protein 35:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI35

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI35 Gene

No ASD Table

Relevant External Links for IFI35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI35 Gene

mRNA expression in normal human tissues for IFI35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFI35 Gene

SOURCE GeneReport for Unigene cluster for IFI35 Gene Hs.632258

mRNA Expression by UniProt/SwissProt for IFI35 Gene

Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells
genes like me logo Genes that share expressions with IFI35: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IFI35 Gene

Orthologs for IFI35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI35 35
  • 98.84 (n)
  • 98.25 (a)
IFI35 36
  • 98 (a)
(Bos Taurus)
Mammalia IFI35 35
  • 80.97 (n)
  • 74.71 (a)
IFI35 36
  • 75 (a)
(Canis familiaris)
Mammalia IFI35 35
  • 79 (n)
  • 74.73 (a)
IFI35 36
  • 73 (a)
(Mus musculus)
Mammalia Ifi35 35
  • 78.32 (n)
  • 72.03 (a)
Ifi35 16
Ifi35 36
  • 72 (a)
(Monodelphis domestica)
Mammalia IFI35 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Ifi35 35
  • 78.9 (n)
  • 72.73 (a)
(Gallus gallus)
Aves IFI35 35
  • 53.06 (n)
  • 40.44 (a)
IFI35 36
  • 35 (a)
(Anolis carolinensis)
Reptilia IFI35 36
  • 29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ifi35 35
  • 48.96 (n)
  • 38.1 (a)
(Danio rerio)
Actinopterygii ifi35 35
  • 49.25 (n)
  • 37.45 (a)
ifi35 36
  • 25 (a)
Species with no ortholog for IFI35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI35 Gene

Gene Tree for IFI35 (if available)
Gene Tree for IFI35 (if available)

Paralogs for IFI35 Gene

Paralogs for IFI35 Gene

genes like me logo Genes that share paralogs with IFI35: view

Variants for IFI35 Gene

Sequence variations from dbSNP and Humsavar for IFI35 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13229 -- 43,013,861(+) GTGAA(A/C/T)GGGGA missense, reference, synonymous-codon
rs443759 -- 43,013,717(-) GCACC(A/G)TAATC intron-variant
rs588703 - 43,013,476(-) GGACA(C/T)CTAGG reference, missense
rs691144 -- 43,011,632(-) agccc(A/G)tctga intron-variant
rs692119 -- 43,005,370(-) gaggc(A/G)gtgaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFI35 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226
esv2672649 CNV Deletion 23128226
esv2662750 CNV Deletion 23128226

Relevant External Links for IFI35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI35 Gene

Disorders for IFI35 Gene

(1) Novoseek inferred disease relationships for IFI35 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for IFI35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFI35: view

No data available for UniProtKB/Swiss-Prot for IFI35 Gene

Publications for IFI35 Gene

  1. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith T.M. … King M.-C. (Genome Res. 1996) 3 4 23
  2. IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PMID: 8954125) Wang X. … Taparowsky E.J. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  3. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PMID: 8288566) Bange F.-C. … Boettger E.C. (J. Biol. Chem. 1994) 3 4 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IFI35 Gene

Sources for IFI35 Gene

Back to Top