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Aliases & Descriptions for IFI35
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ21753 2 | | IFP35 1, 2, 3 |
| | | Descriptions |
|---|
| IFP 35 3 | | interferon-induced protein 35 2 |
|
| | Search outside databases for aliases for IFI35 genePrevious GC identifers: GC17M062367 GC17P043320 GC17P041067 GC17P041532 GC17P041533 |
Summaries for IFI35(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Function: Not yet knownGene Wiki entry for IFI35 |
Genomic Location for IFI35
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFI35 gene 
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21IFI35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038412:
(about GC identifiers)
Start:
|
38,412,351 bp from pter |
End:
|
38,419,999 bp from pter |
Size:
|
7,649 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010755.15
| Proteins for IFI35
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IN35_HUMAN, P80217 (See
protein sequence)Recommended Name: Interferon-induced 35 kDa protein Size: 286 amino acids; 31514 Da
Subunit: Homodimer. Also interacts with B-ATF
Subcellular location: Nucleus. Note=Nuclear following IFN treatment
Secondary accessions: Q92984 Q99537 Q9BV98Alternative splicing: 2 isoforms: P80217-1 P80217-2 REFSEQ proteins: NP_005524.1
ENSEMBL proteins: ENSP00000246911
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: IFI35 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for IFI35: Assays for IFI35: | Protein
Domains/ Families for IFI35(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P80217
ProtoNet protein and cluster: P80217 1 Blocks protein family: IPB009909 Nmi/IFP 35
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Similarity: Belongs to the NMI family | Gene Function for IFI35
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005533
Applied Biosystems Silencer® siRNAs for IFI35
Sigma-Aldrich siRNA for IFI35  Sigma-Aldrich shRNA for IFI35  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005533                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005533                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005533 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005533
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Function: Not yet knownInduction: By interferon gammaGenatlas biochemistry entry for IFI35:interferon-induced leucine zipper protein IFI35,may be the same as APRF1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for IFI35
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for IFI35 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for IFI35 
4 Interacting proteins for IFI35 (P802171 ENSP000002469113) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
NAS | -- | | GO:0009615 | response to virus |
NAS | -- | About this table
|
Drugs & Compounds for IFI35(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFI35 1 Novoseek chemical compound relationship for IFI35 gene
About this table
|
Transcripts for IFI35(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005533
Sigma-Aldrich siRNA for IFI35  Sigma-Aldrich shRNA for IFI35  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005533 REFSEQ mRNAs for IFI35 gene: NM_005533.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005533               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005533                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005533                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005533  Additional cDNA sequence: AK025406.1 BC001356.2 U72882.1 7 DOTS entries: DT.455598 DT.100028280 DT.91753253 DT.92389823 DT.75126564 DT.100778859 DT.120983472 24/201 AceView cDNA sequences (see all 201
):BM996594 BU629908 BE276568 CB130670 CB110077 AW082544 AW118002 BX954767 BQ020479 CB138771 CA748732 BM717524 BM694278 BG749376 BG168316 BQ921917 BE383727 BM857058 BU732151 BM556210 BM806352 BG476389 AA195653 BE735639
highest scoring ESTs for IFI35:AW026462 U72882 AA025690 AA026789 AA088879 AA115662 AA132931 AA195653 AA435595 AA536149 Unigene Cluster for IFI35: Interferon-induced protein 35 Hs.632258 [show with all ESTs]Unigene Representative Sequence: BU539084
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000246911
|
Expression for IFI35
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFI35 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFI35
1 / 2 / 3 5 probe-sets matching IFI35 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACGTCCTGGA
SOURCE GeneReport for Unigene cluster: Hs.632258 UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells |
Orthologs for IFI35
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFI35 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for IFI35
ENSEMBL Gene Tree for IFI35 | Paralogs for IFI35(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFI35 gene
- NMI2
|
SNPs/Variants for IFI35(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFI35 (up to first 250kb)
|
Disorders & Mutations for IFI35
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600735
1 Novoseek disease relationship for IFI35 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
1 |
17197158 (1) |
About this table
|
Medical News for IFI35(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFI35 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for IFI35 gene (see all 15
):- IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PubMed id 8288566)1, 3, 4 Bange F.-C....Boettger E.C. (1994)
- IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PubMed id 8954125)1, 3, 4 Wang X.... Taparowsky E.J. (1996)
- Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 3, 4 Smith T.M....King M.C. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PubMed id 17197158)1, 3 Zhang L.... He F. (2007)
- Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PubMed id 10779520)1, 3 Zhou X....Omary M.B. (2000)
- Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PubMed id 11911807)1, 3 Chen J. and Naumovski L. (2002)
- IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. (PubMed id 18305040)3 Tan J....Geng Y. (2008)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)3 Oh J.H....Kim N.S. (2005)
|
Search for IFI35
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFI35
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFI35
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFI35(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFI35(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFI35:

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Incremental update: 13 Oct 2009
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