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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFI35 Gene

protein-coding   GIFtS: 55
GCID: GC17P041158

Interferon-Induced Protein 35

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon-Induced Protein 351 2
IFP352 3
IFP 352 3
ifi-352
Interferon-Induced 35 KDa Protein2
Ifi-353

External Ids:    HGNC: 53991   Entrez Gene: 34302   Ensembl: ENSG000000680797   OMIM: 6007355   UniProtKB: P802173   

Export aliases for IFI35 gene to outside databases

Previous GC identifers: GC17M062367 GC17P043320 GC17P041067 GC17P041532 GC17P041533 GC17P038412 GC17P036924


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFI35 Gene: 
IFI35 (interferon-induced protein 35) is a protein-coding gene. Diseases associated with IFI35 include diverticulitis, and ovarian cancer, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include protein binding. An important paralog of this gene is NMI.

UniProtKB/Swiss-Prot: IN35_HUMAN, P80217
Function: Not yet known

Gene Wiki entry for IFI35 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFI35 gene promoter:
         SRF   HOXA9   HOXA9B   SRF (504 AA)   RREB-1   MyoD   C/EBPalpha   IRF-7A   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI35 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFI35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

IFI35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI35 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041158:  view genomic region     (about GC identifiers)

Start:
41,158,742 bp from pter      End:
41,166,476 bp from pter
Size:
7,735 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IN35_HUMAN, P80217 (See protein sequence)
Recommended Name: Interferon-induced 35 kDa protein  
Size: 286 amino acids; 31546 Da
Subunit: Homodimer. Also interacts with B-ATF
Subcellular location: Nucleus. Note=Nuclear following IFN treatment
Sequence caution: Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;
Secondary accessions: C9JGX1 Q92984 Q99537 Q9BV98
Alternative splicing: 2 isoforms:  P80217-1   P80217-2   (Variant in position: 128:M->V (in dbSNP:rs588703). Due to a polymorphism at the 3'-splice acceptor site of intron 4)

Explore the universe of human proteins at neXtProt for IFI35: NX_P80217

Explore proteomics data for IFI35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P80217

  • IFI35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFI35 Protein Expression
    REFSEQ proteins: NP_005524.2  
    ENSEMBL proteins: 
     ENSP00000394579   ENSP00000395590  
    Reactome Protein details: P80217
    Human Recombinant Protein Products for IFI35: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFI35 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8288566
    GO:0005829cytosol TAS--

    IFI35 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009938 Interferon_induced_35kDa_N
     IPR009909 Nmi/IFP35

    Graphical View of Domain Structure for InterPro Entry P80217

    ProtoNet protein and cluster: P80217

    1 Blocks protein domain: IPB009909 Nmi/IFP 35

    UniProtKB/Swiss-Prot: IN35_HUMAN, P80217
    Similarity: Belongs to the NMI family


    IFI35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IN35_HUMAN, P80217
    Function: Not yet known
    Induction: By interferon gamma

         Genatlas biochemistry entry for IFI35:
    interferon-induced leucine zipper protein IFI35,may be the same as APRF

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18624398
         
    IFI35 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFI35 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI35 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFI35 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for IFI35
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    IFI35 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFI35

    5 Interacting proteins for IFI35 (P802171, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLEC4GQ6UXB41, 3EBI-2115067,EBI-2114729 I2D: score=2 
    BATFQ165203I2D: score=3 
    NMIQ132873I2D: score=3 
    PLEKHO1Q53GL03I2D: score=3 
    MAPK1P284823I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--
    GO:0009615response to virus NAS--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0060337type I interferon-mediated signaling pathway TAS--

    IFI35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFI35 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFI35 (IN35)

    1 Novoseek inferred chemical compound relationship for IFI35 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 58.5 7 8288566 (3), 8938427 (1), 8668343 (1), 8954125 (1)

    Search CenterWatch for drugs/clinical trials and news about IFI35 / IN35

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFI35 gene: 
    NM_005533.4  

    Unigene Cluster for IFI35:

    Interferon-induced protein 35
    Hs.632258  [show with all ESTs]
    Unigene Representative Sequence: BU539084
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415816(uc021txx.1) ENST00000438323 ENST00000246911 ENST00000536969
    ENST00000396722 ENST00000538473 ENST00000546325 ENST00000534876
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IFI35:
    hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidIFI35 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI35
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI35

    Additional mRNA sequence: 

    AK025406.1 BC001356.2 U72882.1 

    7 DOTS entries:

    DT.455598  DT.100028280  DT.91753253  DT.92389823  DT.75126564  DT.100778859  DT.120983472 

    24/201 AceView cDNA sequences (see all 201):

    BM996594 CB130670 BU629908 CB138771 AW118002 AW082544 CB110077 BX954767 
    CA748732 BM717524 BQ020479 BE276568 BE739495 BQ220477 BQ448708 R48437 
    BE735600 BG339321 BM806352 BP351684 BM826678 BG677454 AA132931 BF026268 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFI35 expression in normal human tissues (normalized intensities)      IFI35 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTCCTGGA
    IFI35 Expression
    About this image


    IFI35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             leukocytes   
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer

    See IFI35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFI35

    SOURCE GeneReport for Unigene cluster: Hs.632258

    UniProtKB/Swiss-Prot: IN35_HUMAN, P80217
    Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells

        SABiosciences Expression via Pathway-Focused PCR Array including IFI35: 
              Interferons & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFI35 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifi351 , 5 interferon-induced protein 351, 5 78.36(n)1
    72.28(a)1
      11 (65.07 cM)5
    701101  NM_027320.41  NP_081596.11 
     1014484075 
    chicken
    (Gallus gallus)
    Aves IFI351 interferon-induced protein 35 52.74(n)
    38.93(a)
      420011  XM_418132.3  XP_418132.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFI356
    Uncharacterized protein
    30(a)
    1 ↔ 1
    6(62507887-62524691)
    zebrafish
    (Danio rerio)
    Actinopterygii ifi351 interferon-induced protein 35 48.12(n)
    36.09(a)
      559610  XM_682968.4  XP_688060.3 


    ENSEMBL Gene Tree for IFI35 (if available)
    TreeFam Gene Tree for IFI35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFI35 gene
    NMI2  

    IFI35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in IFI35 are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728291031,2
    C,F--41156888(+) AGCAAA/TTTTTT 1 -- us2k12Minor allele frequency- T:0.02NA NS 268
    rs1877102531,2
    --41157063(+) GAAGAC/GTTAAT 1 -- us2k10--------
    rs1475073721,2
    --41157085(+) ACAAGC/TGTGTT 1 -- us2k10--------
    rs11082871,2
    C,F,H--41157105(-) AGGAGC/AGCTAT 1 -- us2k113Minor allele frequency- A:0.34NA CSA WA EA 510
    rs1402397931,2
    C--41157123(+) CACTGC/TTAACA 1 -- us2k10--------
    rs1429625111,2
    C--41157126(+) TGTTAA/TCAGTT 1 -- us2k10--------
    rs1131453371,2
    C--41157234(+) CCTCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1916944941,2
    --41157286(+) ACAGGC/TGCATG 1 -- us2k10--------
    rs6921191,2
    C,F--41157387(-) gaggcG/Agtgaa 1 -- us2k15Minor allele frequency- A:0.40NA WA 10
    rs359750181,2
    C--41157441(+) CAGCC-/TTTTTT 1 -- us2k12Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for IFI35 (41158742 - 41166476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IFI35:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662750CNV Deletion23128226
    esv2672649CNV Deletion23128226
    esv2672913CNV Deletion23128226
    nsv457742CNV Loss19166990
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600735    OMIM disorders: --

    3 diseases for IFI35:    About MalaCards
    diverticulitis    ovarian cancer    gastric cancer


    IFI35 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for IFI35 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17197158 (1)

    Genetic Association Database (GAD): IFI35
    Human Genome Epidemiology (HuGE) Navigator: IFI35 (1 document)

    Export disorders for IFI35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFI35 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with IFI35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PubMed id 8288566)1, 2, 9 Bange F.-C....Boettger E.C. (1994)
    2. IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PubMed id 8954125)1, 2, 9 Wang X.... Taparowsky E.J. (1996)
    3. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2, 9 Smith T.M.... King M.-C. (1996)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PubMed id 17197158)1, 9 Zhang L.... He F. (2007)
    8. Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PubMed id 10779520)1, 9 Zhou X....Omary M.B. (2000)
    9. Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PubMed id 11911807)1, 9 Chen J. and Naumovski L. (2002)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3430 HGNC: 5399 AceView: IFI35 Ensembl:ENSG00000068079 euGenes: HUgn3430
    ECgene: IFI35 H-InvDB: IFI35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFI35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFI35 gene:
    Search GeneIP for patents involving IFI35

    GeneCards and IP:
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