 |
 | Services
| |
 |
Aliases & Descriptions for IFI30
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| GILT 1, 2, 3 | | IFI-30 1, 2 | | IP30 1, 2 | | MGC32056 1, 2 |
| | | Descriptions |
|---|
| Gamma-interferon-inducible protein IP-30 3 | | gamma-interferon-inducible lysosomal thiol reductase 2 | | interferon gamma-inducible protein 30 preproprotein 2 | | interferon, gamma-inducible protein 30 2 |
|
| | Search outside databases for aliases for IFI30 genePrevious GC identifers: GC19P018778 GC19P018676 GC19P018129 |
Summaries for IFI30(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for IFI30: The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq] UniProtKB/Swiss-Prot: GILT_HUMAN, P13284Function: Cleaves disulfide bonds in proteins by reduction. May facilitate the complete unfolding of proteins destined for lysosomal degradation. May be involved in MHC class II-restricted antigen processingGene Wiki entry for IFI30 |
Genomic Location for IFI30
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFI30 gene 
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1IFI30 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P018145:
(about GC identifiers)
Start:
|
18,145,579 bp from pter |
End:
|
18,149,927 bp from pter |
Size:
|
4,349 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for IFI30
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GILT_HUMAN, P13284 (See
protein sequence)Recommended Name: Gamma-interferon-inducible lysosomal thiol reductase precursor Size: 261 amino acids; 29149 Da
Subcellular location: Lysosome
Secondary accessions: Q9UL08Post-translational modifications:
N-glycosylated. Sugar chains contain mannose-6-phosphate1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006323.2
ENSEMBL proteins: ENSP00000384886
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IFI30: Assays for IFI30: | Protein
Domains/ Families for IFI30(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P13284
ProtoNet protein and cluster: P13284 UniProtKB/Swiss-Prot: GILT_HUMAN, P13284Similarity: Belongs to the GILT family | Gene Function for IFI30
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006332
Applied Biosystems Silencer® siRNAs for IFI30
Sigma-Aldrich siRNA for IFI30  Sigma-Aldrich shRNA for IFI30  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006332                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006332                                  untagged cDNA clone in CMV expression vector: NM_006332 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006332
UniProtKB/Swiss-Prot: GILT_HUMAN, P13284Function: Cleaves disulfide bonds in proteins by reduction. May facilitate the complete unfolding of proteins destined for lysosomal degradation. May be involved in MHC class II-restricted antigen processingInduction: Expressed constitutively in antigen-presenting cells and induced by IFN-gamma in other cell typesGenatlas biochemistry entry for IFI30:interferon, gamma-inducible protein 30,present and inducible by gamma-interferon (IFN gamma) in cells of the hematopoietic lineage and absent but inducible in non-hematopoietic cells,may be lysosomal in location.1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ifi30):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- | About this table | Pathways & Interactions for IFI30
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
IEA | -- | | GO:0048147 | negative regulation of fibroblast proliferation |
IEA | -- | | GO:0050821 | protein stabilization |
IEA | -- | | GO:0055114 | oxidation reduction |
IEA | -- | About this table
|
Drugs & Compounds for IFI30(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFI30
|
Transcripts for IFI30(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006332
Sigma-Aldrich siRNA for IFI30  Sigma-Aldrich shRNA for IFI30  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006332 REFSEQ mRNAs for IFI30 gene: NM_006332.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006332               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006332                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006332                                  untagged cDNA clone in CMV expression vector: NM_006332  Additional cDNA sequence: AB049659.1 AF401212.1 AK123477.1 AK291551.1 BC021136.1 BC031020.1 CR604887.1 CR611745.1 CR617281.1 CR622428.1 CR622693.1 DQ884410.1 17 DOTS entries: DT.92357957 DT.92448454 DT.92448452 DT.100826104 DT.100826103 DT.95346751 DT.100826085 DT.100826094 DT.100826098 DT.92448449 DT.100826087 DT.95346753 DT.100826093 DT.121450182 DT.92448416 DT.95246806 DT.100826089 24/662 AceView cDNA sequences (see all 662
):CR622693 AA381663 AK123477 AI188638 AJ572034 BE794848 CR604887 H62355 CA310405 AI983936 CR611745 AI355471 CB164729 BM796588 BI837864 BF992579 AU100505 BM051579 AI263513 BU732792 AF401212 AA995528 BQ056241 CR617281
highest scoring ESTs for IFI30:AA126780 AA128359 AA160539 AA173272 AA190455 AA190770 AA191380 AA223663 AA291182 AA291643 Unigene Cluster for IFI30: Interferon, gamma-inducible protein 30 Hs.14623 [show with all ESTs]Unigene Representative Sequence: AK123477
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000407280
|
Expression for IFI30
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFI30 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFI30
1 / 2 / 3 4 probe-sets matching IFI30 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATCAAGAATC
SOURCE GeneReport for Unigene cluster: Hs.14623
Expression variation in blood from EXPOLDB for IFI30 |
Orthologs for IFI30
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFI30 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for IFI30
ENSEMBL Gene Tree for IFI30 | Paralogs for IFI30(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for IFI30(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IFI30 (up to first 250kb)
|
Disorders & Mutations for IFI30
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604664
2 Novoseek disease relationships for IFI30 gene
About this table
1 PharmGKB disease relationship for IFI30 geneAbout this table
Human Genome Epidemiology Navigator: IFI30 (1 document)
|
Medical News for IFI30(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFI30 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/34 PubMed articles for IFI30 gene (see all 34
):- Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). (PubMed id 10639150)1, 2, 3, 4 Arunachalam B....Cresswell P. (2000)
- Molecular and biochemical characterization of a novel gamma- interferon-inducible protein. (PubMed id 3136170)2, 3, 4 Luster A.D.... Ravetch J.V. (1988)
- Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT). (PubMed id 12198183)1, 3 Phan U.T....Cresswell P. (2002)
- Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. (PubMed id 10852914)1, 3 Phan U.T....Cresswell P. (2000)
- Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma. (PubMed id 18343923)1, 3 Goldstein O.G....Haque A. (2008)
- Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. (PubMed id 12021307)1, 3 Haque M.A....Blum J.S. (2002)
- Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions. (PubMed id 18410276)1, 3 Satoh J....Konno H. (2008)
- Multiple species express thiol oxidoreductases related to GILT. (PubMed id 11491538)1, 3 Phan U.T....Cresswell P. (2001)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
|
Search for IFI30
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFI30
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFI30
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFI30(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFI30(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFI30:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins ( IFI30 ) | | Antibodies ( IFI30 ) |
| | | Search Tocris compounds for IFI30 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|