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Aliases for IFI27L2 Gene

Aliases for IFI27L2 Gene

  • Interferon Alpha Inducible Protein 27 Like 2 2 3 5
  • Family With Sequence Similarity 14, Member A 2 3
  • Interferon-Stimulated Gene 12b Protein 3 4
  • PIFI27-Like Protein 3 4
  • FAM14A 3 4
  • TLH29 3 4
  • Interferon Alpha-Inducible Protein 27-Like Protein 2 3
  • ISG12(B) Protein 3
  • Protein TLH29 4
  • ISG12(B) 4
  • ISG12B 3

External Ids for IFI27L2 Gene

Previous HGNC Symbols for IFI27L2 Gene

  • FAM14A

Previous GeneCards Identifiers for IFI27L2 Gene

  • GC14M093664
  • GC14M094594
  • GC14M074773

Summaries for IFI27L2 Gene

GeneCards Summary for IFI27L2 Gene

IFI27L2 (Interferon Alpha Inducible Protein 27 Like 2) is a Protein Coding gene. An important paralog of this gene is IFI27L1.

Additional gene information for IFI27L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI27L2 Gene

Genomics for IFI27L2 Gene

Regulatory Elements for IFI27L2 Gene

Enhancers for IFI27L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H094128 0.9 ENCODE 37.3 +0.8 839 1.9 PKNOX1 ZSCAN4 ZNF76 KLF17 ZBTB40 GLIS2 EGR1 ZNF366 ZNF143 IKZF2 IFI27L2 ASB2 IFI27
GH14H094384 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -261.4 -261390 15.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 ATF7 PAF1 SP5 SERPINA1 IFI27L2 SERPINA11 SERPINA9 ENSG00000256357 SERPINA2
GH14H094173 1.2 Ensembl ENCODE 18.7 -44.5 -44518 2.9 INSM2 ARID4B SIN3A ZNF76 KLF17 BMI1 FEZF1 GLIS2 ZNF366 ZNF391 PPP4R4 IFI27L2 IFI27L1 DDX24 LOC105370634 GC14M094218
GH14H094180 1 Ensembl ENCODE 19.5 -50.6 -50600 1.1 CTCF SAP130 ZNF133 ARID4B ZNF384 RAD21 TEAD3 ZFHX2 SMC3 ATF7 IFI27L2 PPP4R4 IFI27L1 DDX24 LOC105370634 GC14M094218
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFI27L2 on UCSC Golden Path with GeneCards custom track

Promoters for IFI27L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072484 553 1401 PKNOX1 ZSCAN4 ZNF76 KLF17 ZBTB40 GLIS2 EGR1 ZNF366 ZNF143 IKZF2

Genomic Locations for IFI27L2 Gene

Genomic Locations for IFI27L2 Gene
2,475 bases
Minus strand

Genomic View for IFI27L2 Gene

Genes around IFI27L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27L2 Gene

Proteins for IFI27L2 Gene

  • Protein details for IFI27L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 27-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TBD7
    • Q9NYL0

    Protein attributes for IFI27L2 Gene

    130 amino acids
    Molecular mass:
    12410 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF65760.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305}; Sequence=AAH22800.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IFI27L2 Gene

Post-translational modifications for IFI27L2 Gene

No Post-translational modifications

Other Protein References for IFI27L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI27L2 Gene

Domains & Families for IFI27L2 Gene

Gene Families for IFI27L2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFI27L2 Gene


Suggested Antigen Peptide Sequences for IFI27L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFI6/IFI27 family.
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27L2: view

Function for IFI27L2 Gene

Phenotypes From GWAS Catalog for IFI27L2 Gene

genes like me logo Genes that share phenotypes with IFI27L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI27L2 Gene

Localization for IFI27L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27L2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27L2 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFI27L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27L2: view

Pathways & Interactions for IFI27L2 Gene

SuperPathways for IFI27L2 Gene

No Data Available

Interacting Proteins for IFI27L2 Gene

Selected Interacting proteins: Q9H2X8-I27L2_HUMAN for IFI27L2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IFI27L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for IFI27L2 Gene

Drugs & Compounds for IFI27L2 Gene

No Compound Related Data Available

Transcripts for IFI27L2 Gene

Unigene Clusters for IFI27L2 Gene

Interferon, alpha-inducible protein 27-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for IFI27L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI27L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI27L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IFI27L2 Gene:


SOURCE GeneReport for Unigene cluster for IFI27L2 Gene:


Evidence on tissue expression from TISSUES for IFI27L2 Gene

  • Pancreas(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with IFI27L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27L2 Gene

Orthologs for IFI27L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI27L2 33 34
  • 99.04 (n)
(Bos Taurus)
Mammalia IFI27L2 33 34
  • 77.24 (n)
-- 34
  • 36 (a)
ISG12(B) 34
  • 29 (a)
(Mus musculus)
Mammalia Ifi27 34
  • 22 (a)
(Gallus gallus)
Aves IFI27L2 34
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
-- 34
  • 25 (a)
(Danio rerio)
Actinopterygii zgc:152791 34
  • 51 (a)
zgc:123068 34
  • 48 (a)
si:dkey-188i13.10 34
  • 47 (a)
si:dkey-188i13.11 34
  • 47 (a)
si:dkey-188i13.7 34
  • 38 (a)
si:dkey-188i13.6 34
  • 37 (a)
si:dkey-188i13.9 34
  • 34 (a)
Species where no ortholog for IFI27L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27L2 Gene

Gene Tree for IFI27L2 (if available)
Gene Tree for IFI27L2 (if available)

Paralogs for IFI27L2 Gene

Paralogs for IFI27L2 Gene

(3) SIMAP similar genes for IFI27L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFI27L2: view

Variants for IFI27L2 Gene

Sequence variations from dbSNP and Humsavar for IFI27L2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000069567 -- 94,130,262(+) GACCG(-/T)TTTTT upstream-variant-2KB
rs1000319698 -- 94,131,205(+) ACTAC(A/C)ATTAT upstream-variant-2KB
rs1000604153 -- 94,129,832(+) GCCCC(C/G)CACTC upstream-variant-2KB
rs1001074417 -- 94,129,380(+) GGAGG(A/G)AAGCA intron-variant
rs1001845754 -- 94,129,741(+) CCCGG(-/CTTGA)TGGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFI27L2 Gene

Variant ID Type Subtype PubMed ID
esv3635373 CNV gain 21293372
esv34067 CNV loss 18971310

Variation tolerance for IFI27L2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI27L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27L2 Gene

Disorders for IFI27L2 Gene

Relevant External Links for IFI27L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFI27L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI27L2 Gene

Publications for IFI27L2 Gene

  1. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu SJ … Fournier RE (Mammalian genome : official journal of the International Mammalian Genome Society 2004) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for IFI27L2 Gene

Sources for IFI27L2 Gene

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