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IFI27L2 Gene

protein-coding   GIFtS: 45
GCID: GC14M094594

Interferon, Alpha-Inducible Protein 27-Like 2

(Previous names: family with sequence similarity 14, member A)
(Previous symbol: FAM14A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interferon, Alpha-Inducible Protein 27-Like 21 2     ISG12B2
FAM14A1 2 3     Interferon Alpha-Inducible Protein 27-Like Protein 22
Family With Sequence Similarity 14, Member A1 2     ISG12(B) Protein2
Interferon-Stimulated Gene 12b Protein2 3     ISG12(b)3
TLH292 3     Protein TLH293
PIFI27-Like Protein2 3     

External Ids:    HGNC: 197531   Entrez Gene: 839822   Ensembl: ENSG000001196327   OMIM: 6113195   UniProtKB: Q9H2X83   
ORGUL members:         

Export aliases for IFI27L2 gene to outside databases

Previous GC identifers: GC14M093664 GC14M074773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFI27L2 Gene:
IFI27L2 (interferon, alpha-inducible protein 27-like 2) is a protein-coding gene. Diseases associated with IFI27L2 include hepatitis, and endotheliitis. An important paralog of this gene is IFI27.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  NT_187601.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFI27L2 gene promoter:
         PPAR-alpha   PPAR-gamma1   NF-1   Pbx1a   PPAR-gamma2   CUTL1   RORalpha2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI27L2 promoter sequence
   Search Chromatin IP Primers for IFI27L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFI27L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.13

IFI27L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27L2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094594:  view genomic region     (about GC identifiers)

Start:
94,594,116 bp from pter      End:
94,596,590 bp from pter
Size:
2,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I27L2_HUMAN, Q9H2X8 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 27-like protein 2 precursor  
Size: 130 amino acids; 12410 Da
Sequence caution: Sequence=AAF65760.1; Type=Frameshift; Positions=99; Sequence=AAH22800.2; Type=Erroneous
initiation;
Secondary accessions: Q8TBD7 Q9NYL0

Explore the universe of human proteins at neXtProt for IFI27L2: NX_Q9H2X8

REFSEQ proteins: NP_114425.1  
ENSEMBL proteins: 
 ENSP00000238609   ENSP00000451717  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009311 IFI6/IFI27

Graphical View of Domain Structure for InterPro Entry Q9H2X8

ProtoNet protein and cluster: Q9H2X8

1 Blocks protein domain: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: I27L2_HUMAN, Q9H2X8
Similarity: Belongs to the IFI6/IFI27 family


IFI27L2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for IFI27L2:
 Synthetic lethal with Ras 

     1 MGI phenotypic allele for Ifi27l2a (no phenotypes)

IFI27L2 for phenotypes           About GeneDecksing

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
I27L2_HUMAN, Q9H2X8: Membrane; Single-pass type I membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

IFI27L2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFI27L2
Interactions:

    Search GeneGlobe Interaction Network for IFI27L2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFI27L2 (I27L2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFI27L2 gene: 
NM_032036.2  

Unigene Cluster for IFI27L2:

Interferon, alpha-inducible protein 27-like 2
Hs.94695  [show with all ESTs]
Unigene Representative Sequence: BU596980
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555558 ENST00000554909 ENST00000238609(uc001ycq.3) ENST00000556727
ENST00000553601 ENST00000556552
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat IFI27L2

Additional mRNA sequence: 

AF208232.1 AF238978.1 BC022800.2 BC032626.1 

4 DOTS entries:

DT.210034  DT.92420139  DT.95081316  DT.92004239 

Selected AceView cDNA sequences (see all 64):

BG339549 AF208232 CB129623 CD672554 BC032626 BM801273 AI214682 CK819950 
BC022800 CA413778 BQ962754 BM142195 CD108025 CK819951 CD107374 CD672514 
BM141888 AA643326 BQ183045 BN000226 BP350347 BP360793 BP335839 BP336077 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L2    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:                        
SP2:        -               


ECgene alternative splicing isoforms for IFI27L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFI27L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGATGCAAA
IFI27L2 Expression
About this image


IFI27L2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Adult Endothelial Cells Blood Brain Barrier
         Cerebral Cortex
 
 Heart (Cardiovascular System)
         Mature Cardiac Fibroblasts Myocardium
 
 Fibroblasts
         Mature Cardiac Fibroblasts Myocardium
 
 Endothelium (Cardiovascular System)
         Adult Endothelial Cells Blood Brain Barrier
 
 Liver (Hepatobiliary System)
         Mature Mesothelial Cells Hepatic Mesenchyme
IFI27L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.94695
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27L2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IFI27L2 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifi27l2a5 interferon, alpha-inducible protein 27 like 2A   --   12 (52.93 cM) 103442167 
chicken
(Gallus gallus)
Aves IFI27L26
Gallus gallus interferon, alpha-inducible protein ...
56(a)
1 → many
23(4295102-4296014)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
61(a)
25(a)
many ↔ many
many ↔ many
GL343498.1(96838-99481)
GL343558.1(288340-297430)
zebrafish
(Danio rerio)
Actinopterygii zgc:1527916
zgc:1230686
(see all 7)
zgc:123068
(see all 7)
51(a)
48(a)
(see all 7)
many ↔ many
many ↔ many
(see all 7)
13(38014818-38017588) ENSDARG00000039243
13(38003194-38005739) ENSDARG00000017489


ENSEMBL Gene Tree for IFI27L2 (if available)
TreeFam Gene Tree for IFI27L2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFI27L2 gene
IFI272  IFI27L12  
3 SIMAP similar genes for IFI27L2 using alignment to 1 protein entry:     I27L2_HUMAN:
IFI27L1    IFI27    IFI6

IFI27L2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFI27L2 (see all 117)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1177985721,2
C,F--94593808(+) ACAGAG/AGGCTC 1 -- int11Minor allele frequency- A:0.04NA 120
rs1491206001,2
C--94593868(+) CAACA-/GGGAGC 1 -- int10--------
rs101456271,2
C,F,A,H--94593917(+) GCCCAG/AAAAAG 1 -- int121Minor allele frequency- A:0.26NS EA NA WA 2342
rs1161542361,2
C,F--94594004(+) TCTGCG/ATGGCC 1 -- int11Minor allele frequency- A:0.04WA 118
rs1464636221,2
--94594034(+) TCCATA/GACAGG 1 -- int10--------
rs1407758211,2
--94594063(+) AGAACG/TGGAAA 1 -- int10--------
rs2002227301,2
--94594112(+) AAACAC/GGGAGA 1 -- int10--------
rs1446280661,2
C--94594139(+) CTTTAG/TTCCTC 2 E D mis10--------
rs9110831,2
C,F,H--94594155(+) TCTCTG/AACTTG 2 /S /L mis1 ese311Minor allele frequency- A:0.00NA EA MN NS 1058
rs1996855811,2
--94594315(+) TGTGGA/CGAGTC 2 A S mis10--------

HapMap Linkage Disequilibrium report for IFI27L2 (94594116 - 94596590 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IFI27L2:    About this table    
Variant IDTypeSubtypePubMed ID
esv34067CNV Loss18971310

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFI27L2
DNA2.0 Custom Variant and Variant Library Synthesis for IFI27L2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611319    OMIM disorders: --

2 diseases for IFI27L2:    
About MalaCards
hepatitis    endotheliitis


IFI27L2 for disorders           About GeneDecksing


Export disorders for IFI27L2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFI27L2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IFI27L2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (BMC Genomics 2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)1 Namciu S.J....Fournier R.E. (Mamm. Genome 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83982 HGNC: 19753 AceView: FAM14A Ensembl:ENSG00000119632 euGenes: HUgn83982
ECgene: IFI27L2 H-InvDB: IFI27L2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFI27L2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFI27L2 gene:
Search GeneIP for patents involving IFI27L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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