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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFI27L2 Gene

protein-coding GIFtS: 43
GCID: GC14M094594

interferon, alpha-inducible protein 27-like 2

(Previous names: family with sequence similarity 14, member A )
(Previous symbol: FAM14A)

Search for IFI27L2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 27-Like 2¹ ²		ISG12B²
FAM14A¹ ² ³		Interferon Alpha-Inducible Protein 27-Like Protein 2²
TLH29¹ ² ³		ISG12(B) Protein²
Family With Sequence Similarity 14, Member A¹ ²		ISG12(B)¹
Interferon-Stimulated Gene 12b Protein² ³		Protein TLH29³
PIFI27-Like Protein² ³

External Ids:	HGNC: 19753¹	Entrez Gene: 83982²	Ensembl: ENSG00000119632⁷	OMIM: 611319⁵	UniProtKB: Q9H2X8³

Export aliases for IFI27L2 gene to outside databases

Previous GC identifers: GC14M093664 GC14M074773

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFI27L2 gene promoter:
PPAR-alpha PPAR-gamma1 NF-1 Pbx1a PPAR-gamma2 CUTL1 RORalpha2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFI27L2 promoter sequence

Search SABiosciences Chromatin IP Primers for IFI27L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.13

IFI27L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27L2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M094594: view genomic region (about GC identifiers)

Start:	94,594,116 bp from pter	End:	94,596,590 bp from pter
Size:	2,475 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I27L2_HUMAN, Q9H2X8 (See protein sequence)

Recommended Name: Interferon alpha-inducible protein 27-like protein 2 precursor

Size: 130 amino acids; 12410 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=AAF65760.1; Type=Frameshift; Positions=99; Sequence=AAH22800.2; Type=Erroneous initiation;

Secondary accessions: Q8TBD7 Q9NYL0

Explore the universe of human proteins at neXtProt for IFI27L2: NX_Q9H2X8

IFI27L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_114425.1

ENSEMBL proteins:

ENSP00000238609 ENSP00000451717

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	Uscn Proteins for IFI27L2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

IFI27L2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFI27L2 for domains About GeneDecksing

1 InterPro domain/family:

IPR009311 Interferon-induced_6-16

Graphical View of Domain Structure for InterPro Entry Q9H2X8

ProtoNet protein and cluster: Q9H2X8

1 Blocks protein family: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: I27L2_HUMAN, Q9H2X8

Similarity: Belongs to the IFI6/IFI27 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for IFI27L2:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFI27L2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for IFI27L2 gene:

NM_032036.2

Unigene Cluster for IFI27L2:

Interferon, alpha-inducible protein 27-like 2

Hs.94695 [show with all ESTs]

Unigene Representative Sequence: BU596980

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000555558 ENST00000554909 ENST00000238609(uc001ycq.3) ENST00000556727

ENST00000553601 ENST00000556552

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Additional cDNA sequence:

AF208232.1 AF238978.1 BC022800.2 BC032626.1

4 DOTS entries:

DT.210034 DT.92420139 DT.95081316 DT.92004239

24/64 AceView cDNA sequences (see all 64):

BM801273 BC032626 CK819950 CK819951 BC022800 BG339549 CD672514 BM142195

AI214682 BM141888 BQ962754 CD108025 CB129623 CD107374 AF208232 CA413778

CD672554 AF238978 BG337287 BQ183045 BE612658 BI760682 BP336077 AA587040

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L2 About this scheme

ExUns:	1	^	2	^	3a	·	3b
SP1:
SP2:			-

ECgene alternative splicing isoforms for IFI27L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFI27L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGATGCAAA

About this image

IFI27L2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Epiblast-like cells (Reconstitution of mo...)

See IFI27L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFI27L2

SOURCE GeneReport for Unigene cluster: Hs.94695

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L2 gene from 4/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ifi27l2a^{1 , 5}	interferon, alpha-inducible protein 27 like 2A^{1, 5}	70.37(n)¹ 67.78(a)¹		12 (52.93 cM)⁵ 76933¹ NM_029803.2¹ NP_084079.1¹ 103442167⁵
chicken (Gallus gallus)	Aves	IFI27L2¹	interferon, alpha-inducible protein 27-like 2	63.89(n) 65.48(a)		403121 NM_001002856.1 NP_001002856.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	59(a) 24(a)	possible ortholog possible ortholog	GL343498.1(96838-99481) GL343558.1(288340-297430)
zebrafish (Danio rerio)	Actinopterygii	zgc:152791⁶ si:dkey-188i13.11⁶ (see all 8)	si:dkey-188i13.11 (see all 8)	54(a) 48(a) (see all 8)	possible ortholog possible ortholog (see all 8)	13(38014818-38017588) 13(38047971-38053988)

ENSEMBL Gene Tree for IFI27L2 (if available)
TreeFam Gene Tree for IFI27L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFI27L2 gene

IFI27² IFI6² IFI27L1²

3 SIMAP similar genes for IFI27L2 using alignment to 1 protein entry: I27L2_HUMAN:

IFI27L1 IFI27 IFI6

IFI27L2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117798572^1,2	C,F,	--	94593808(+)	`ACAGAG/AGNNNN`	1	--	int¹		1		NA	120
rs149120600^1,2	C,	--	94593868(+)	`CAACA-/GGGAGC`	1	--	int¹		0	--	--	--	--
rs10145627^1,2	C,F,A,H,	--	94593917(+)	`GCCCAG/AAAAAG`	1	--	int¹		21		NS EA NA WA	2342
rs116154236^1,2	C,F,	--	94594004(+)	`TCTGCG/ATGGCC`	1	--	int¹		1		WA	118
rs146463622^1,2		--	94594034(+)	`TCCATA/GACAGG`	1	--	int¹		0	--	--	--	--
rs140775821^1,2		--	94594063(+)	`AGAACG/TGGAAA`	1	--	int¹		0	--	--	--	--
rs200222730^1,2		--	94594112(+)	`AAACAC/GGGAGA`	1	--	int¹		0	--	--	--	--
rs144628066^1,2	C,	--	94594139(+)	`CTTTAG/TTCCTC`	2	E D	mis¹		0	--	--	--	--
rs911083^1,2	C,F,H	--	94594155(+)	`TCTCTG/AACTTG`	2	/S /L	mis¹ ese³		11		NA EA MN NS	1058
rs199685581^1,2		--	94594315(+)	`TGTGGA/CGAGTC`	2	A S	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFI27L2 (94594116 - 94596590 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFI27L2
1 CNV: 47863

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFI27L2 for disorders About MalaCards

IFI27L2 for disorders About GeneDecksing

OMIM gene information: 611319 OMIM disorders: --

Export disorders for IFI27L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFI27L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IFI27L2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)^{1, 2} Parker N. and Porter A.C.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)¹ Namciu S.J....Fournier R.E. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83982	HGNC: 19753	AceView: FAM14A	Ensembl:ENSG00000119632	euGenes: HUgn83982
ECgene: IFI27L2	H-InvDB: IFI27L2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFI27L2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFI27L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFI27L2 gene:
Search GeneIP for patents involving IFI27L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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IFI27L2 Gene

interferon, alpha-inducible protein 27-like 2

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IFI27L2 Gene

interferon, alpha-inducible protein 27-like 2

Aliasesfor IFI27L2 gene

Summariesfor IFI27L2 gene

Genomic Viewsfor IFI27L2 gene

Proteinsfor IFI27L2 gene

Protein Domains /Familiesfor IFI27L2 gene

Functionfor IFI27L2 gene

Pathways & Interactionsfor IFI27L2 gene

Drugs & Compoundsfor IFI27L2 gene

Transcriptsfor IFI27L2 gene

Expression for IFI27L2 gene

Orthologsfor IFI27L2 gene

Paralogsfor IFI27L2 gene

Genomic Variantsfor IFI27L2 gene

Disorders / Diseasesfor IFI27L2 gene

Publicationsfor IFI27L2 gene

External Searches for IFI27L2 gene

Genome Databases showing IFI27L2 gene

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Specialized Databases showing IFI27L2 gene

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Aliases
for IFI27L2 gene

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for IFI27L2 gene

Genomic Views
for IFI27L2 gene

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for IFI27L2 gene

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Families
for IFI27L2 gene

Function
for IFI27L2 gene

Pathways & Interactions
for IFI27L2 gene

Drugs & Compounds
for IFI27L2 gene

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for IFI27L2 gene

Expression
for IFI27L2 gene

Orthologs
for IFI27L2 gene

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for IFI27L2 gene

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for IFI27L2 gene

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for IFI27L2 gene

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for IFI27L2 gene