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Aliases for IFI27L1 Gene

Aliases for IFI27L1 Gene

  • Interferon Alpha Inducible Protein 27 Like 1 2 3 5
  • Family With Sequence Similarity 14, Member B 2 3
  • Interferon-Stimulated Gene 12c Protein 3 4
  • FAM14B 3 4
  • Interferon Alpha-Inducible Protein 27-Like Protein 1 3
  • ISG12(C) Protein 3
  • ISG12(C) 4
  • ISG12C 3

External Ids for IFI27L1 Gene

Previous HGNC Symbols for IFI27L1 Gene

  • FAM14B

Previous GeneCards Identifiers for IFI27L1 Gene

  • GC14P093618
  • GC14P094547
  • GC14P074727

Summaries for IFI27L1 Gene

GeneCards Summary for IFI27L1 Gene

IFI27L1 (Interferon Alpha Inducible Protein 27 Like 1) is a Protein Coding gene. An important paralog of this gene is IFI27L2.

Additional gene information for IFI27L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI27L1 Gene

Genomics for IFI27L1 Gene

Regulatory Elements for IFI27L1 Gene

Enhancers for IFI27L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H094109 1.1 ENCODE dbSUPER 43.3 +29.5 29478 2 TBP KLF17 RFX5 ZNF766 CREM CAVIN1 ZNF592 MEF2D NFIC GLIS1 IFI27L1 DDX24 IFI27L2 IFI27
GH14H094113 0.9 ENCODE dbSUPER 23.4 +33.1 33132 2 SOX13 HLF KLF17 ZIC2 NR2F2 GATA3 GLIS2 ZNF366 ZBTB48 POLR2A IFI27L1 PPP4R4 DDX24 IFI27 IFI27L2
GH14H094020 1.1 Ensembl ENCODE 15.2 -59.1 -59093 2 SOX13 SAP130 MLX ARID4B CEBPG DMAP1 ZIC2 RARA ZFHX2 RERE IFI27L1 CCDC197 ASB2 DDX24 SERPINA2 OTUB2 GC14M094050 GC14M094051
GH14H094097 0.4 ENCODE 39.9 +17.2 17228 1 ZFHX2 IFI27L1 IFI27L2 OTUB2 GC14P094102 PIR54711
GH14H094173 1.2 Ensembl ENCODE 10.7 +93.5 93489 2 INSM2 ARID4B SIN3A ZNF76 KLF17 BMI1 FEZF1 GLIS2 ZNF366 ZNF391 PPP4R4 IFI27L2 IFI27L1 DDX24 LOC105370634 GC14M094218
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFI27L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFI27L1 Gene

94,081,282 bp from pter
94,103,846 bp from pter
22,565 bases
Plus strand

Genomic View for IFI27L1 Gene

Genes around IFI27L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27L1 Gene

Proteins for IFI27L1 Gene

  • Protein details for IFI27L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 27-like protein 1
    Protein Accession:

    Protein attributes for IFI27L1 Gene

    104 amino acids
    Molecular mass:
    9549 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFI27L1 Gene

neXtProt entry for IFI27L1 Gene

Post-translational modifications for IFI27L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI27L1 Gene

Domains & Families for IFI27L1 Gene

Gene Families for IFI27L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI27L1 Gene


Suggested Antigen Peptide Sequences for IFI27L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFI6/IFI27 family.
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27L1: view

Function for IFI27L1 Gene

Phenotypes From GWAS Catalog for IFI27L1 Gene

Phenotypes for IFI27L1 Gene

genes like me logo Genes that share phenotypes with IFI27L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFI27L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI27L1 Gene

Localization for IFI27L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27L1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27L1 gene
Compartment Confidence
extracellular 3
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFI27L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFI27L1 Gene

Pathways & Interactions for IFI27L1 Gene

SuperPathways for IFI27L1 Gene

No Data Available

Interacting Proteins for IFI27L1 Gene

Gene Ontology (GO) - Biological Process for IFI27L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IFI27L1 Gene

Drugs & Compounds for IFI27L1 Gene

No Compound Related Data Available

Transcripts for IFI27L1 Gene

Unigene Clusters for IFI27L1 Gene

Interferon, alpha-inducible protein 27-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFI27L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - -

Relevant External Links for IFI27L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI27L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI27L1 Gene

mRNA differential expression in normal tissues according to GTEx for IFI27L1 Gene

This gene is overexpressed in Testis (x6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI27L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFI27L1 Gene:


SOURCE GeneReport for Unigene cluster for IFI27L1 Gene:


Evidence on tissue expression from TISSUES for IFI27L1 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with IFI27L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27L1 Gene

Orthologs for IFI27L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI27L1 34
  • 99 (a)
(Canis familiaris)
Mammalia -- 34
  • 67 (a)
(Mus musculus)
Mammalia Ifi27l2a 34
  • 60 (a)
Ifi27l2b 34
  • 19 (a)
(Bos Taurus)
Mammalia IFI27 34
  • 27 (a)
(Gallus gallus)
Aves IFI27L2 34
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
-- 34
  • 23 (a)
(Danio rerio)
Actinopterygii zgc:152791 34
  • 48 (a)
si:dkey-188i13.11 34
  • 47 (a)
zgc:123068 34
  • 45 (a)
si:dkey-188i13.10 34
  • 44 (a)
si:dkey-188i13.6 34
  • 37 (a)
si:dkey-188i13.7 34
  • 33 (a)
si:dkey-188i13.9 34
  • 33 (a)
Species where no ortholog for IFI27L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27L1 Gene

Gene Tree for IFI27L1 (if available)
Gene Tree for IFI27L1 (if available)

Paralogs for IFI27L1 Gene

Paralogs for IFI27L1 Gene

(2) SIMAP similar genes for IFI27L1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IFI27L1: view

Variants for IFI27L1 Gene

Sequence variations from dbSNP and Humsavar for IFI27L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000116595 -- 94,085,045(+) TGTGT(C/T)CCAGT intron-variant
rs1000250016 -- 94,079,754(+) TGAAA(A/G)GGAGA intron-variant, upstream-variant-2KB
rs1000329857 -- 94,091,272(+) CAGCC(A/G)CTATT intron-variant
rs1000489783 -- 94,085,894(+) TTTTG(C/G)TATTT intron-variant
rs1000500249 -- 94,096,324(+) ATCCC(G/T)GATGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFI27L1 Gene

Variant ID Type Subtype PubMed ID
esv2669953 CNV deletion 23128226
esv34067 CNV loss 18971310
esv3635373 CNV gain 21293372
esv3892577 CNV gain 25118596
nsv565621 CNV gain 21841781

Variation tolerance for IFI27L1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI27L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27L1 Gene

Disorders for IFI27L1 Gene

Relevant External Links for IFI27L1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFI27L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI27L1 Gene

Publications for IFI27L1 Gene

  1. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PMID: 19260139) Polasek O … Rudan I (Croatian medical journal 2009) 3 45 60
  2. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PMID: 22609626) Klammt C … Choe S (Nature methods 2012) 4 60
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 60

Products for IFI27L1 Gene

Sources for IFI27L1 Gene

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