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Aliases for IFI27L1 Gene

Aliases for IFI27L1 Gene

  • Interferon Alpha Inducible Protein 27 Like 1 2 3 5
  • Family With Sequence Similarity 14, Member B 2 3
  • Interferon-Stimulated Gene 12c Protein 3 4
  • FAM14B 3 4
  • Interferon Alpha-Inducible Protein 27-Like Protein 1 3
  • ISG12(C) Protein 3
  • ISG12(C) 4
  • ISG12C 3

External Ids for IFI27L1 Gene

Previous HGNC Symbols for IFI27L1 Gene

  • FAM14B

Previous GeneCards Identifiers for IFI27L1 Gene

  • GC14P093618
  • GC14P094547
  • GC14P074727

Summaries for IFI27L1 Gene

GeneCards Summary for IFI27L1 Gene

IFI27L1 (Interferon Alpha Inducible Protein 27 Like 1) is a Protein Coding gene. An important paralog of this gene is IFI27L2.

Additional gene information for IFI27L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI27L1 Gene

Genomics for IFI27L1 Gene

GeneHancer (GH) Regulatory Elements for IFI27L1 Gene

Promoters and enhancers for IFI27L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094079 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.1 -0.3 -292 3.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 POLR2B GLIS2 DDX24 IFI27L1 PIR58882 BTBD7 IFI27 PPP4R4
GH14I094109 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 43.3 +29.5 29530 2.8 KLF17 RFX5 ZNF766 CREM CAVIN1 ZNF592 MEF2D NFIC GLIS1 IKZF1 IFI27 IFI27L1 DDX24 IFI27L2
GH14I094173 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +93.5 93488 2.9 INSM2 ARID4B KLF17 MZF1 ZNF76 SIN3A BMI1 FEZF1 ZNF335 GLIS2 PPP4R4 IFI27L2 IFI27L1 DDX24 LOC105370634 GC14M094218
GH14I094025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 -53.3 -53267 4.1 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B IRF4 ZNF207 ZNF548 FOS OTUB2 BTBD7 DDX24 CCDC197 ASB2 IFI27L2 IFI27L1 IFI27 GC14M094050 GC14M094051
GH14I094113 Enhancer 0.8 ENCODE dbSUPER 23.5 +33.1 33131 2.6 SOX13 HLF KLF17 ZIC2 NR2F2 ZNF335 GLIS2 GATA3 POLR2A ZNF366 IFI27L1 PPP4R4 DDX24 IFI27 IFI27L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFI27L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFI27L1 gene promoter:

Genomic Locations for IFI27L1 Gene

Genomic Locations for IFI27L1 Gene
chr14:94,081,282-94,103,846
(GRCh38/hg38)
Size:
22,565 bases
Orientation:
Plus strand
chr14:94,547,628-94,570,192
(GRCh37/hg19)

Genomic View for IFI27L1 Gene

Genes around IFI27L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27L1 Gene

Proteins for IFI27L1 Gene

  • Protein details for IFI27L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BM0-I27L1_HUMAN
    Recommended name:
    Interferon alpha-inducible protein 27-like protein 1
    Protein Accession:
    Q96BM0

    Protein attributes for IFI27L1 Gene

    Size:
    104 amino acids
    Molecular mass:
    9549 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFI27L1 Gene

neXtProt entry for IFI27L1 Gene

Post-translational modifications for IFI27L1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IFI27L1 Gene

Domains & Families for IFI27L1 Gene

Gene Families for IFI27L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI27L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IFI27L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BM0

UniProtKB/Swiss-Prot:

I27L1_HUMAN :
  • Belongs to the IFI6/IFI27 family.
Family:
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27L1: view

Function for IFI27L1 Gene

Phenotypes From GWAS Catalog for IFI27L1 Gene

Phenotypes for IFI27L1 Gene

genes like me logo Genes that share phenotypes with IFI27L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI27L1 Gene

Localization for IFI27L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27L1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27L1 gene
Compartment Confidence
extracellular 3
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFI27L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFI27L1 Gene

Pathways & Interactions for IFI27L1 Gene

SuperPathways for IFI27L1 Gene

No Data Available

Interacting Proteins for IFI27L1 Gene

Gene Ontology (GO) - Biological Process for IFI27L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFI27L1 Gene

Drugs & Compounds for IFI27L1 Gene

No Compound Related Data Available

Transcripts for IFI27L1 Gene

Unigene Clusters for IFI27L1 Gene

Interferon, alpha-inducible protein 27-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - - - - - -
SP9:
SP10: - - - - - -
SP11: - - - - - - - - -

Relevant External Links for IFI27L1 Gene

GeneLoc Exon Structure for
IFI27L1
ECgene alternative splicing isoforms for
IFI27L1

Expression for IFI27L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI27L1 Gene

mRNA differential expression in normal tissues according to GTEx for IFI27L1 Gene

This gene is overexpressed in Testis (x6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI27L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of IFI27L1 Gene:

IFI27L1

SOURCE GeneReport for Unigene cluster for IFI27L1 Gene:

Hs.19414

Evidence on tissue expression from TISSUES for IFI27L1 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with IFI27L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27L1 Gene

Orthologs for IFI27L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI27L1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifi27l2a 34
  • 60 (a)
ManyToMany
Ifi27l2b 34
  • 19 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia IFI27 34
  • 27 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFI27L2 34
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:152791 34
  • 48 (a)
ManyToMany
si:dkey-188i13.11 34
  • 47 (a)
ManyToMany
zgc:123068 34
  • 45 (a)
ManyToMany
si:dkey-188i13.10 34
  • 44 (a)
ManyToMany
si:dkey-188i13.6 34
  • 37 (a)
ManyToMany
si:dkey-188i13.7 34
  • 33 (a)
ManyToMany
si:dkey-188i13.9 34
  • 33 (a)
ManyToMany
Species where no ortholog for IFI27L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27L1 Gene

ENSEMBL:
Gene Tree for IFI27L1 (if available)
TreeFam:
Gene Tree for IFI27L1 (if available)

Paralogs for IFI27L1 Gene

Paralogs for IFI27L1 Gene

(2) SIMAP similar genes for IFI27L1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IFI27L1: view

Variants for IFI27L1 Gene

Sequence variations from dbSNP and Humsavar for IFI27L1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000116595 -- 94,085,045(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000250016 -- 94,079,754(+) A/G upstream_transcript_variant
rs1000329857 -- 94,091,272(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000489783 -- 94,085,894(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000500249 -- 94,096,324(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFI27L1 Gene

Variant ID Type Subtype PubMed ID
esv2669953 CNV deletion 23128226
esv34067 CNV loss 18971310
esv3635373 CNV gain 21293372
esv3892577 CNV gain 25118596
nsv565621 CNV gain 21841781

Variation tolerance for IFI27L1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI27L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI27L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27L1 Gene

Disorders for IFI27L1 Gene

Additional Disease Information for IFI27L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFI27L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI27L1 Gene

Publications for IFI27L1 Gene

  1. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PMID: 19260139) Polasek O … Rudan I (Croatian medical journal 2009) 3 44 58
  2. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PMID: 22609626) Klammt C … Choe S (Nature methods 2012) 4 58
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58

Products for IFI27L1 Gene

Sources for IFI27L1 Gene

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