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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFI27L1 Gene

protein-coding   GIFtS: 44
GCID: GC14P094547

Interferon, Alpha-Inducible Protein 27-Like 1

(Previous names: family with sequence similarity 14, member B)
(Previous symbol: FAM14B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 27-Like 11 2     ISG12C2
FAM14B1 2 3     Interferon Alpha-Inducible Protein 27-Like Protein 12
Family With Sequence Similarity 14, Member B1 2     ISG12(C) Protein2
Interferon-Stimulated Gene 12c Protein2 3     ISG12(c)3

External Ids:    HGNC: 197541   Entrez Gene: 1225092   Ensembl: ENSG000001659487   OMIM: 6113205   UniProtKB: Q96BM03   

Export aliases for IFI27L1 gene to outside databases

Previous GC identifers: GC14P093618 GC14P074727


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFI27L1 Gene: 
IFI27L1 (interferon, alpha-inducible protein 27-like 1) is a protein-coding gene. Diseases associated with IFI27L1 include hepatitis b, and hepatitis. An important paralog of this gene is IFI27L2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFI27L1 gene promoter:
         HOXA9   HOXA9B   AML1a   CUTL1   Tal-1beta   LCR-F1   E47   Meis-1a   ATF6   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFI27L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFI27L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.13

IFI27L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27L1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P094547:  view genomic region     (about GC identifiers)

Start:
94,547,628 bp from pter      End:
94,570,192 bp from pter
Size:
22,565 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I27L1_HUMAN, Q96BM0 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 27-like protein 1  
Size: 104 amino acids; 9549 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for IFI27L1:
2LOQ (3D)    

Explore the universe of human proteins at neXtProt for IFI27L1: NX_Q96BM0

Explore proteomics data for IFI27L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BM0

  • IFI27L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFI27L1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_660292.1  NP_996832.1  

    ENSEMBL proteins: 
     ENSP00000451851   ENSP00000376824   ENSP00000452226   ENSP00000451459   ENSP00000451043  
     ENSP00000451608   ENSP00000450463   ENSP00000451676   ENSP00000451889   ENSP00000450620  

    Human Recombinant Protein Products for IFI27L1: 
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    Novus Biologicals IFI27L1 Lysates
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    Cloud-Clone Corp. Proteins for IFI27L1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    IFI27L1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for IFI27L1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009311 Interferon-induced_6-16

    Graphical View of Domain Structure for InterPro Entry Q96BM0

    ProtoNet protein and cluster: Q96BM0

    1 Blocks protein domain: IPB009311 Interferon-induced 6-16

    UniProtKB/Swiss-Prot: I27L1_HUMAN, Q96BM0
    Similarity: Belongs to the IFI6/IFI27 family


    IFI27L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for IFI27L1:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFI27L1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFI27L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI27L1 
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    Inhib. RNA
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    Search LifeMap BioReagents cell lines for IFI27L1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFI27L1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFI27L1 (I27L1)

    Search CenterWatch for drugs/clinical trials and news about IFI27L1 / I27L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFI27L1 gene (2 alternative transcripts): 
    NM_145249.2  NM_206949.2  

    Unigene Cluster for IFI27L1:

    Interferon, alpha-inducible protein 27-like 1
    Hs.19414  [show with all ESTs]
    Unigene Representative Sequence: BX418628
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555523(uc001ycl.3) ENST00000553350 ENST00000557600 ENST00000393115(uc001yck.3)
    ENST00000555065 ENST00000554166 ENST00000556381 ENST00000553664 ENST00000555341
    ENST00000557218 ENST00000554544 ENST00000557066 ENST00000554562
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFI27L1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFI27L1
    SwitchGear 3'UTR luciferase reporter plasmidIFI27L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFI27L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI27L1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI27L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27L1
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                         Customized lentivirus expression plasmids for stable overexpression of IFI27L1 
    Primer
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    OriGene qPCR primer pairs and template standards for IFI27L1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFI27L1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFI27L1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27L1

    Additional mRNA sequence: BC015423.1 

    10 DOTS entries:

    DT.95151316  DT.102835378  DT.92460620  DT.454113  DT.100653733  DT.120774489  DT.92460646  DT.99946111 
    DT.95160001  DT.95246539 

    24/319 AceView cDNA sequences (see all 319):

    CD368997 BQ636466 CA394524 AI889225 BQ636873 AI281133 AI799444 CK826087 
    BM756566 BM841596 AW272283 BU074244 BX117580 AA149289 BM991281 BM987761 
    AU098768 CA307308 CB113159 AW473943 BC015492 BU163500 BT006781 BQ687647 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
    SP1:                                            -     -     -     -     -                       -           -                           
    SP2:                                                  -     -     -     -           -           -           -                           
    SP3:                                            -     -     -     -                             -           -                           
    SP4:                                            -     -     -     -     -           -           -           -                           
    SP5:                                            -     -     -                       -           -           -                           


    ECgene alternative splicing isoforms for IFI27L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFI27L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFI27L1 Expression
    About this image


    See IFI27L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFI27L1

    SOURCE GeneReport for Unigene cluster: Hs.19414
        SABiosciences Custom PCR Arrays for IFI27L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFI27L1 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IFI27L26
    interferon alpha-inducible protein 27-like protein...
    51(a)
    1 → many
    23(4295102-4296014)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    23(a)
    many ↔ many
    many ↔ many
    GL343498.1(96838-99481)
    GL343558.1(288340-297430)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1527916
    si:dkey-188i13.116
    (see all 8)
    si:dkey-188i13.11
    (see all 8)
    49(a)
    45(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    13(38014818-38017588)
    13(38047971-38053988)
            Species with no ortholog for IFI27L1

    ENSEMBL Gene Tree for IFI27L1 (if available)
    TreeFam Gene Tree for IFI27L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFI27L1 gene
    IFI27L22  IFI272  IFI62  
    2 SIMAP similar genes for IFI27L1 using alignment to 8 protein entries:     I27L1_HUMAN (see all proteins):
    IFI27L2    IFI6

    IFI27L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/467 SNPs in IFI27L1 are shown (see all 467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891086931,2
    --94549617(+) GAACAA/GTTCCT 2 -- int10--------
    rs1930409261,2
    --94549662(+) ATACAA/GTCTAC 2 -- int10--------
    rs1161110541,2
    F--94549670(+) TACTCC/ATGGTG 2 -- int11Minor allele frequency- A:0.04WA 118
    rs1413140961,2
    --94549912(+) ACCTCA/GCCTTT 2 -- int10--------
    rs1423576111,2
    --94549930(+) CACCAC/TCCTAA 2 -- int10--------
    rs750512701,2
    C,F--94550106(+) GTTGAG/ATAAAT 2 -- int12Minor allele frequency- A:0.05CSA WA 120
    rs1512401141,2
    --94550216(+) GGATCA/GCTTGG 2 -- int10--------
    rs727023111,2
    C,F--94550225(+) GGGCTC/GTGGAG 2 -- int11Minor allele frequency- G:0.03NA 120
    rs19503441,2
    C,F,A,H--94550300(+) AGAAAG/CAGAGT 2 -- int1 trp314Minor allele frequency- C:0.31NA NS EA WA 914
    rs1844782141,2
    --94550332(+) GGGGAC/GGGGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for IFI27L1 (94547628 - 94570192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IFI27L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669953CNV Deletion23128226
    esv34067CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611320    OMIM disorders: --

    2 diseases for IFI27L1:    About MalaCards
    hepatitis b    hepatitis


    IFI27L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IFI27L1
    Human Genome Epidemiology (HuGE) Navigator: IFI27L1 (1 document)

    Export disorders for IFI27L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFI27L1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IFI27L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (2009)
    2. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (2012)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)1 Namciu S.J....Fournier R.E. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 122509 HGNC: 19754 AceView: IFI27andFAM14B Ensembl:ENSG00000165948 euGenes: HUgn122509
    ECgene: IFI27L1 H-InvDB: IFI27L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFI27L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFI27L1 gene:
    Search GeneIP for patents involving IFI27L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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