IFI27L1 Gene
protein-coding GIFtS: 44
GCID: GC14P094547
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|
interferon, alpha-inducible protein 27-like 1(Previous names: family with sequence similarity 14, member B )
(Previous symbol: FAM14B)
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Aliases
for IFI27L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha-Inducible Protein 27-Like 11 2 | | ISG12C2 | | FAM14B1 2 3 | | Interferon Alpha-Inducible Protein 27-Like Protein 12 | | Family With Sequence Similarity 14, Member B1 2 | | ISG12(C) Protein2 | | Interferon-Stimulated Gene 12c Protein2 3 | | ISG12(C)1 |
Export aliases for IFI27L1 gene to outside databasesPrevious GC identifers: GC14P093618 GC14P074727 |
Summaries
for IFI27L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IFI27L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFI27L1 gene promoter:
HOXA9 HOXA9B AML1a CUTL1 Tal-1beta LCR-F1 E47 Meis-1a ATF6 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFI27L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.13IFI27L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P094547: view genomic region
(about GC identifiers)
Start:
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94,547,628 bp from pter |
End:
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94,570,192 bp from pter |
Size:
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22,565 bases |
Orientation:
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plus strand |
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Proteins
for IFI27L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I27L1_HUMAN, Q96BM0 (See
protein sequence)Recommended Name: Interferon alpha-inducible protein 27-like protein 1 Size: 104 amino acids; 9549 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
1 PDB 3D structure from  and Proteopedia  for IFI27L1:2LOQ (3D)
Explore the universe of human proteins at neXtProt for IFI27L1: NX_Q96BM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BM0
IFI27L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_660292.1 NP_996832.1
ENSEMBL proteins: ENSP00000451851 ENSP00000376824 ENSP00000452226 ENSP00000451459 ENSP00000451043 ENSP00000451608 ENSP00000450463 ENSP00000451676 ENSP00000451889 ENSP00000450620
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
IFI27L1 for ontologies About GeneDecksing
IFI27L1 Antibody Products:
Assay Products for IFI27L1: |
Protein
Domains /
Families
for IFI27L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFI27L1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96BM0ProtoNet protein and cluster: Q96BM0 1 Blocks protein family: IPB009311 Interferon-induced 6-16
UniProtKB/Swiss-Prot: I27L1_HUMAN, Q96BM0Similarity: Belongs to the IFI6/IFI27 family |
Function
for IFI27L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27L1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27L1 (see all 2)
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Synthesis Service for IFI27L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27L1 |
1 GenomeRNAi human phenotype for IFI27L1:
|
Pathways & Interactions
for IFI27L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFI27L1
|
Drugs & Compounds
for IFI27L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFI27L1
Search CenterWatch for drugs/clinical trials and news about IFI27L1 / I27L1
|
Transcripts
for IFI27L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFI27L1 gene (2 alternative transcripts): NM_145249.2 NM_206949.2 Unigene Cluster for IFI27L1: Interferon, alpha-inducible protein 27-like 1 Hs.19414 [show with all ESTs]Unigene Representative Sequence: BX41862813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555523(uc001ycl.3) ENST00000553350 ENST00000557600 ENST00000393115(uc001yck.3)
ENST00000555065 ENST00000554166 ENST00000556381 ENST00000553664 ENST00000555341
ENST00000557218 ENST00000554544 ENST00000557066 ENST00000554562
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27L1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27L1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IFI27L1 (NM_206949) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFI27L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27L1 |
Additional cDNA sequence: BC015423.1 10 DOTS entries: DT.95151316 DT.102835378 DT.92460620 DT.454113 DT.100653733 DT.120774489 DT.92460646 DT.99946111 DT.95160001 DT.95246539 24/319 AceView cDNA sequences (see all 319): BM991281 AI285118 BX281853 CB529359 BE208583 AJ711493 BQ636466 CD365269 AW272283 BI825895 BQ416830 CB104730 BU185176 BM713642 AA604552 AI889225 CB104733 BM841596 BC015492 BU738964 BQ687647 AK095039 BT006781 CD367237
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L1 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | - | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for IFI27L1
|
Expression
for IFI27L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFI27L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IFI27L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFI27L1
SOURCE GeneReport for Unigene cluster: Hs.19414
SABiosciences Custom PCR Arrays for IFI27L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFI27L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFI27L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27L1 |
Orthologs
for IFI27L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFI27L1 gene from 3/6 species (see all 6) About this table
ENSEMBL Gene Tree for IFI27L1 (if available)
TreeFam Gene Tree for IFI27L1 (if available) |
Paralogs
for IFI27L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFI27L1 gene
- IFI27L22 IFI272 IFI62
2 SIMAP similar genes for IFI27L1 using alignment to 8 protein entries: I27L1_HUMAN (see all proteins):IFI27L2 IFI6
IFI27L1 for paralogs About GeneDecksing
|
Genomic Variants
for IFI27L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFI27L1 (94547628 - 94570192 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFI27L1
1 CNV: 47863 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFI27L1 |
|
Disorders
/ Diseases
for IFI27L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFI27L1 for disorders About GeneDecksing
OMIM gene information: 611320
OMIM disorders: --
2  diseases for IFI27L1: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: IFI27L1 (1 document)
Export disorders for IFI27L1 gene to outside databases
|
Publications
for IFI27L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFI27L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IFI27L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1 Polasek O....Rudan I. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)1 Namciu S.J....Fournier R.E. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for IFI27L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFI27L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFI27L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFI27L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFI27L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFI27L1 gene:
Search GeneIP for patents involving IFI27L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFI27L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFI27L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFI27L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI27L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27L1 |
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 | | | IFI27L1 Proteins, Antibodies, CLIAs, and ELISAs |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27L1 |
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