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Aliases for IFI27 Gene

Aliases for IFI27 Gene

  • Interferon, Alpha-Inducible Protein 27 2 3
  • Interferon Alpha-Induced 11.5 KDa Protein 3 4
  • Interferon-Stimulated Gene 12a Protein 3 4
  • ISG12(A) 3 4
  • P27 3 4
  • Interferon Alpha-Inducible Protein 27, Mitochondrial 3
  • 2310061N23Rik 3
  • FAM14D 3
  • ISG12A 3
  • ISG12 3

External Ids for IFI27 Gene

Previous GeneCards Identifiers for IFI27 Gene

  • GC14P092084
  • GC14P088393
  • GC14P092567
  • GC14P093646
  • GC14P094577
  • GC14P074756

Summaries for IFI27 Gene

GeneCards Summary for IFI27 Gene

IFI27 (Interferon, Alpha-Inducible Protein 27) is a Protein Coding gene. Diseases associated with IFI27 include encapsulated thymoma and invasive bladder transitional cell carcinoma. Among its related pathways are Interferon Signaling and Interferon Signaling. An important paralog of this gene is IFI27L2.

UniProtKB/Swiss-Prot for IFI27 Gene

  • Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.

Gene Wiki entry for IFI27 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI27 Gene

Genomics for IFI27 Gene

Regulatory Elements for IFI27 Gene

Genomic Location for IFI27 Gene

94,104,836 bp from pter
94,116,699 bp from pter
11,864 bases
Plus strand

Genomic View for IFI27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFI27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27 Gene

Proteins for IFI27 Gene

  • Protein details for IFI27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 27, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53YA6
    • Q6IEC1
    • Q96BK3

    Protein attributes for IFI27 Gene

    119 amino acids
    Molecular mass:
    11268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFI27 Gene

Proteomics data for IFI27 Gene at MOPED

Post-translational modifications for IFI27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI27 Gene

Domains for IFI27 Gene

Protein Domains for IFI27 Gene


Graphical View of Domain Structure for InterPro Entry



  • P40305
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27: view

No data available for Gene Families for IFI27 Gene

Function for IFI27 Gene

Molecular function for IFI27 Gene

GENATLAS Biochemistry: interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma
UniProtKB/Swiss-Prot Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.
UniProtKB/Swiss-Prot Induction: Up-regulated by interferons.

Gene Ontology (GO) - Molecular Function for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 22427340
GO:0003674 molecular_function ND --
GO:0005521 lamin binding IDA 22427340
genes like me logo Genes that share ontologies with IFI27: view

Animal Model Products

CRISPR Products

miRNA for IFI27 Gene

miRTarBase miRNAs that target IFI27

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFI27 Gene

Localization for IFI27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27 Gene

Mitochondrion. Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for IFI27 Gene COMPARTMENTS Subcellular localization image for IFI27 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IDA 22427340
GO:0005739 mitochondrion IDA 18330707
GO:0005741 mitochondrial outer membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27: view

Pathways for IFI27 Gene

genes like me logo Genes that share pathways with IFI27: view

Pathways by source for IFI27 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IFI27 Gene

Selected Interacting proteins: P40305-IFI27_HUMAN for IFI27 Gene via I2D

Gene Ontology (GO) - Biological Process for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 22427340
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18330707
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0046825 regulation of protein export from nucleus IGI 22427340
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with IFI27: view

Compounds for IFI27 Gene

(72) Novoseek inferred chemical compound relationships for IFI27 Gene

Compound -log(P) Hits PubMed IDs
optimax 71 1
eb 1089 53.1 8
mevastatin 50.6 2
roscovitine 49.5 1
p00048 48.7 1
genes like me logo Genes that share compounds with IFI27: view

Transcripts for IFI27 Gene

Unigene Clusters for IFI27 Gene

Interferon, alpha-inducible protein 27:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -

Relevant External Links for IFI27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI27 Gene

mRNA expression in normal human tissues for IFI27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI27 Gene

This gene is overexpressed in Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IFI27 Gene

SOURCE GeneReport for Unigene cluster for IFI27 Gene Hs.532634

genes like me logo Genes that share expressions with IFI27: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IFI27 Gene

Orthologs for IFI27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI27 35
  • 98.6 (n)
  • 97.48 (a)
IFI27 36
  • 86 (a)
(Bos Taurus)
Mammalia IFI27 36
  • 26 (a)
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
(Mus musculus)
Mammalia Ifi27l1 16
Ifi27l2a 36
  • 59 (a)
Ifi27l2b 36
  • 19 (a)
(Gallus gallus)
Aves IFI27L2 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 22 (a)
(Danio rerio)
Actinopterygii si:dkey-188i13.10 36
  • 38 (a)
si:dkey-188i13.11 36
  • 41 (a)
si:dkey-188i13.6 36
  • 30 (a)
si:dkey-188i13.7 36
  • 30 (a)
si:dkey-188i13.9 36
  • 31 (a)
zgc:123068 36
  • 42 (a)
zgc:152791 36
  • 49 (a)
Species with no ortholog for IFI27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27 Gene

Gene Tree for IFI27 (if available)
Gene Tree for IFI27 (if available)

Paralogs for IFI27 Gene

Paralogs for IFI27 Gene

Selected SIMAP similar genes for IFI27 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with IFI27: view

Variants for IFI27 Gene

Sequence variations from dbSNP and Humsavar for IFI27 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2799 -- 94,116,589(+) CCATC(C/G)TGACC utr-variant-3-prime
rs1042951 -- 94,116,521(+) AGGTT(C/T)TACTA reference, synonymous-codon
rs1243080 -- 94,111,842(+) TGTCC(A/C/T)GGGAC intron-variant
rs1243081 -- 94,117,125(+) AACCC(C/T)GCGCA intron-variant
rs2227974 - 94,116,484(+) GGGCT(C/T)CATTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFI27 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV Loss 18971310

Relevant External Links for IFI27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27 Gene

Disorders for IFI27 Gene

(95) Novoseek inferred disease relationships for IFI27 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 78.6 52
tumors 69.1 204
cancer 59.1 47
breast cancer 57.3 55
laryngeal squamous cell carcinoma 54.6 10

Relevant External Links for IFI27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFI27: view

No data available for UniProtKB/Swiss-Prot for IFI27 Gene

Publications for IFI27 Gene

  1. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PMID: 8358738) Rasmussen U.B. … Basset P. (Cancer Res. 1993) 2 3 4 23
  2. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N. … Porter A.C.G. (BMC Genomics 2004) 3 4
  3. Genetic variations in humans associated with differences in the course of hepatitis C. (PMID: 15063762) Saito T. … Kawata S. (Biochem. Biophys. Res. Commun. 2004) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L. … Crovella S. (J. Gastroenterol. Hepatol. 2009) 3 48

Products for IFI27 Gene

Sources for IFI27 Gene

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