Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFI27 Gene

protein-coding GIFtS: 55
GCID: GC14P094577

interferon, alpha-inducible protein 27

Explore 123 diseases affiliated with
IFI27 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 27¹ ²		2310061N23Rik²
FAM14D¹ ²		ISG12²
P27¹ ²		ISG12A²
Interferon Alpha-Induced 11.5 KDa Protein² ³		Interferon Alpha-Inducible Protein 27, Mitochondrial²
Interferon-Stimulated Gene 12a Protein² ³		P27¹ ²
ISG12(A)¹

External Ids:	HGNC: 5397¹	Entrez Gene: 3429²	Ensembl: ENSG00000165949⁷	OMIM: 600009⁵	UniProtKB: P40305³

Export aliases for IFI27 gene to outside databases

Previous GC identifers: GC14P092084 GC14P088393 GC14P092567 GC14P093646 GC14P074756

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305

Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome

C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9

Gene Wiki entry for IFI27

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFI27 gene promoter:
STAT1 HOXA5 STAT1beta IRF-7A STAT5A IRF-1 STAT1alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFI27 promoter sequence

Search SABiosciences Chromatin IP Primers for IFI27

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.12

IFI27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P094577: view genomic region (about GC identifiers)

Start:	94,571,182 bp from pter	End:	94,583,033 bp from pter
Size:	11,852 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 (See protein sequence)

Recommended Name: Interferon alpha-inducible protein 27, mitochondrial precursor

Size: 119 amino acids; 11268 Da

Subcellular location: Mitochondrion. Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q53YA6 Q6IEC1 Q96BK3

Explore the universe of human proteins at neXtProt for IFI27: NX_P40305

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P40305

IFI27 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005523.3 NP_001123552.1

ENSEMBL proteins:

ENSP00000451370 ENSP00000450753 ENSP00000452495 ENSP00000451875 ENSP00000298902

ENSP00000451987 ENSP00000452560 ENSP00000451956 ENSP00000452012 ENSP00000413536

ENSP00000410901

Reactome Protein details: P40305
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IFI27 OriGene Custom Protein Services for IFI27
	GenScript Custom Purified and Recombinant Proteins Services for IFI27
	Novus Biologicals IFI27 Protein Novus Biologicals IFI27 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IFI27

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	18330707
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0016021	integral to membrane	NAS	--

IFI27 for ontologies About GeneDecksing

IFI27 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for IFI27
	GenScript Custom Superior Antibodies Services for IFI27
	Novus Biologicals IFI27 Antibodies
	Search for Antibodies for IFI27 at Abcam
	Uscn Antibodies for IFI27
	Search ThermoFisher Antibodies for IFI27

Assay Products for IFI27:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IFI27
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IFI27

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFI27 for domains About GeneDecksing

1 InterPro domain/family:

IPR009311 Interferon-induced_6-16

Graphical View of Domain Structure for InterPro Entry P40305

ProtoNet protein and cluster: P40305

1 Blocks protein family: IPB009311 Interferon-induced 6-16

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305

Similarity: Belongs to the IFI6/IFI27 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305

Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome

C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9

Induction: Up-regulated by interferons

Genatlas biochemistry entry for IFI27:

interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IFI27 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFI27
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IFI27:
		hsa-miR-942
		SwitchGear 3'UTR luciferase reporter plasmid: IFI27 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFI27 OriGene shRNA RFP: IFI27 OriGene siRNA: IFI27
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI27

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFI27

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IFI27 (NM_001130080)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI27
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFI27
		Search LifeMap BioReagents cell lines for IFI27

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFI27

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

IFI27 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Expression of IFN-induced genes

Expression of IFN-induced genes

1.00

Interferon alpha/beta signaling

0.61

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for IFI27

	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Expression of IFN-induced genes
	Interferon Signaling
	Immune System

IFI27 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IFI27

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for IFI27 (P40305³ ENSP00000298902⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802³, ENSP00000257904⁴	I2D: score=2 STRING: ENSP00000257904
SKP2	Q13309³, ENSP00000274255⁴	I2D: score=1 STRING: ENSP00000274255
CCND1	P24385³, ENSP00000227507⁴	I2D: score=2 STRING: ENSP00000227507
PSMC6	ENSP00000401802⁴	STRING: ENSP00000401802
PSMC3	ENSP00000298852⁴	STRING: ENSP00000298852

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	18330707
GO:0008633	activation of pro-apoptotic gene products	--	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0060337	type I interferon-mediated signaling pathway	TAS	--
GO:0097190	apoptotic signaling pathway	IDA	18330707

IFI27 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFI27 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFI27
10/72 Novoseek chemical compound relationships for IFI27 gene (see all 72) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
optimax	71	1	15385108 (1)
eb 1089	53.1	13	12408227 (6), 10640426 (2)
mevastatin	50.6	2	11181044 (1), 12475985 (1)
roscovitine	49.5	1	8670807 (1)
p00048	48.7	2	9741540 (1)
norcantharidin	45.7	4	16784656 (3), 17287171 (1)
troglitazone	45.4	7	17143939 (2), 11343236 (2), 12595159 (2), 18474441 (1)
mg 132	44.7	1	17493842 (1)
estrogen	43	30	17681750 (3), 16601291 (2), 17540032 (1), 10861499 (1) (see all 23)
hmba	41	9	10597222 (4), 14575541 (2), 17349212 (1), 15182584 (1)

Search CenterWatch for drugs/clinical trials and news about IFI27

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFI27 gene (2 alternative transcripts):

NM_005532.3 NM_001130080.1

Unigene Cluster for IFI27:

Interferon, alpha-inducible protein 27

Hs.532634 [show with all ESTs]

Unigene Representative Sequence: BQ053892

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000554448(uc001ycm.1) ENST00000557098 ENST00000555081 ENST00000557700

ENST00000554800 ENST00000556544 ENST00000298902 ENST00000555819 ENST00000557634

ENST00000555744 ENST00000553285 ENST00000557035 ENST00000555121 ENST00000444961

ENST00000448882(uc001ycn.1 uc021sba.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IFI27 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFI27
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IFI27:
		hsa-miR-942
		SwitchGear 3'UTR luciferase reporter plasmid: IFI27 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFI27 OriGene shRNA RFP: IFI27 OriGene siRNA: IFI27
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI27

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IFI27 (NM_001130080)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI27
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFI27 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFI27
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27

Additional cDNA sequence:

AJ294851.2 AK289535.1 AK312089.1 AY126456.1 AY126457.1 AY126458.1 BC015492.1 BT006781.1

BX647330.1 X67325.1

12 DOTS entries:

DT.100827656 DT.97854455 DT.100827644 DT.97854456 DT.100827655 DT.97764309 DT.95330631 DT.120768611

DT.100042157 DT.120768610 DT.91952463 DT.95330627

24/319 AceView cDNA sequences (see all 319):

AI889225 CA394524 AY126458 AW272283 BU730574 BM841596 AW085700 BF378268

BU185176 AA157089 BQ052022 AA132661 BM840473 BU074244 AI799444 AJ711493

BQ416830 BM704423 BM849859 BM694377 BX281853 AA938119 AA309950 CB122858

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:			-								-		-		-				-
SP2:			-		-						-		-		-				-
SP3:			-		-		-				-		-		-				-
SP4:							-				-		-		-				-
SP5:																			-

ECgene alternative splicing isoforms for IFI27

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFI27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGGGAGA

About this image

IFI27 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Bone

Zeugopod Epiphyseal End

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See IFI27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFI27

SOURCE GeneReport for Unigene cluster: Hs.532634

SABiosciences Expression via Pathway-Focused PCR Arrays including IFI27:

Interferons & Receptors in human mouse rat

Type I Interferon Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFI27 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFI27
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFI27

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFI27 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IFI27L2⁶	putative ISG12-1 protein	53(a)	1 → many	23(4661933-4665616)
lizard (Anolis carolinensis)	Reptilia	-- --	--	51(a) 21(a)	possible ortholog possible ortholog	GL343498.1(96838-99481) GL343558.1(288340-297430)
zebrafish (Danio rerio)	Actinopterygii	zgc:152791⁶ si:dkey-188i13.11⁶ (see all 8)	si:dkey-188i13.11 (see all 8)	50(a) 41(a) (see all 8)	possible ortholog possible ortholog (see all 8)	13(38014818-38017588) 13(38047971-38053988)

ENSEMBL Gene Tree for IFI27 (if available)
TreeFam Gene Tree for IFI27 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFI27 gene

IFI27L2² IFI6² IFI27L1²

3 SIMAP similar genes for IFI27 using alignment to 10 protein entries: IFI27_HUMAN (see all proteins):

ISG12 IFI27L2 IFI6

IFI27 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74077213^1,2	C,F,	--	74754981(+)	`CCAGGG/ATGGCC`	1	--	us2k¹		3	WA CSA	122
rs77810274^1,2	F,	--	74755907(+)	`AAGCCT/CTGCTG`	1	--	us2k¹		1	WA	118
rs28489163^1,2	C,F,H,	--	74756048(+)	`TGCAGG/AGTGAG`	1	--	us2k¹		19	NS EA NA WA CSA	2049
rs111491063^1,2		--	74756268(+)	`CCACAC/AGGGCT`	1	--	us2k¹		2	CSA WA	120
rs74077216^1,2	C,F,	--	74756649(+)	`TCTGCG/ATAGAG`	1	--	us2k¹		3	WA CSA	122
rs114607965^1,2	C,F,	--	74756679(+)	`TAAATG/TACAAA`	1	--	us2k¹		1	WA	118
rs74617881^1,2		--	74757004(+)	`GGCCCC/TGGACC`	1	--	int¹		1	NA	120
rs74077217^1,2	C,F,	--	74757424(+)	`TGCTGT/CATATG`	1	--	int¹		3	WA CSA	122
rs79237972^1,2	F,	--	74757656(+)	`ATCCTT/CTCAAG`	1	--	int¹		1	EA	120
rs112353168^1,2	C,	--	74757991(+)	`AAGGGC/TGGGGG`	1	--	int¹		2	WA	120

HapMap Linkage Disequilibrium report for IFI27 (94571182 - 94583033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFI27
1 CNV: 47863

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFI27

DNA2.0 Custom Variant and Variant Library Synthesis for IFI27

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFI27 for disorders           About GeneDecksing

OMIM gene information: 600009    OMIM disorders: --

20/123 diseases for IFI27 (see all 123):    About MalaCards

smooth muscle tumor diffuse large b-cell lymphoma maxillary sinus squamous cell carcinoma invasive bladder transitional cell carcinoma

cervical intraepithelial neoplasia encapsulated thymoma bladder transitional cell carcinoma dna topoisomerase ii

gastrointestinal stromal tumor squamous cell carcinoma extramedullary plasmacytoma adenomatous polyposis coli

b-cell lymphomas laryngeal squamous cell carcinoma transitional cell carcinoma testicular germ cell tumor

clear cell renal cell carcinoma inverted papilloma non-hodgkin lymphoma leukoplakia

10/95 Novoseek disease relationships for IFI27 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	78.6	54	18701138 (3), 10365095 (2), 11221854 (2), 12907249 (2) (see all 47)
tumors	69.1	408	11237531 (6), 14647411 (6), 11002215 (5), 11679944 (5) (see all 99)
cancer	59.1	69	15086558 (2), 15996662 (2), 11038303 (2), 15082919 (2) (see all 42)
breast cancer	57.3	60	10454252 (4), 15082919 (4), 10353599 (3), 10066070 (3) (see all 37)
laryngeal squamous cell carcinoma	54.6	15	12669430 (4), 16116829 (2), 15742257 (1), 10334237 (1) (see all 6)
carcinoma squamous cell	54.6	39	17203174 (4), 10738177 (3), 11314778 (3), 14719078 (2) (see all 23)
carcinoma	54.6	83	17384651 (3), 9160891 (3), 11903577 (3), 19447418 (3) (see all 51)
colon cancer	49	6	19723652 (3), 19505918 (2), 12920809 (1)
metastasis	47.5	65	11932323 (3), 18925698 (3), 17909030 (2), 12494250 (2) (see all 38)
laryngeal carcinoma	46.8	5	12669430 (3), 15646812 (1), 10506612 (1)

Genetic Association Database (GAD): IFI27
Human Genome Epidemiology (HuGE) Navigator: IFI27 (5 documents)

Export disorders for IFI27 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFI27 gene, integrated from 9 sources (see all 867):
(articles sorted by number of sources associating them with IFI27)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PubMed id 8358738)^{1, 2, 3, 9} Rasmussen U.B.... Basset P. (1993)
Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. (PubMed id 18330707)^{1, 2} Rosebeck S. and Leaman D.W. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)^{1, 2} Parker N. and Porter A.C.G. (2004)
Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas. (PubMed id 14719078)^{1, 9} Taguchi T....Tsukuda M. (2004)
The interferon stimulated gene 12 inactivates vasculop rotective functions of NR4A nuclear receptors. (PubMed id 22427340)¹ Papac-Milicevic N....Binder B.R. (2012)
Interferon-inducible genes, TNF-related apoptosis-indu cing ligand (TRAIL) and interferon inducible protein 27 (IFI27) are negatively r egulated in leiomyomas: implications for a role of the interferon pathway in lei omyoma development. (PubMed id 22320196)¹ Mihalich A....Di Blasio A. (2012)
Dihydrotestosterone induces p27 degradation via direc t binding with SKP2 in ovarian and breast cancer. (PubMed id 21503567)¹ Shi P....Shao Z. (2011)
Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors. (PubMed id 22309998)¹ Moschovi M....Alexiou G.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3429	HGNC: 5397	AceView: IFI27andFAM14B	Ensembl:ENSG00000165949	euGenes: HUgn3429
ECgene: IFI27	H-InvDB: IFI27

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFI27	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFI27 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFI27 gene:
Search GeneIP for patents involving IFI27

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for IFI27
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFI27		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFI27
	OriGene Protein Over-expression Lysate for IFI27		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IFI27		OriGene 3'-UTR Clone for IFI27
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFI27
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IFI27		OriGene Custom Protein Services for IFI27
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFI27
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFI27
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFI27
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFI27

	GenScript Custom Purified and Recombinant Proteins Services for IFI27		GenScript cDNA clones with any tag delivered in your preferred vector for IFI27
	GenScript Custom Assay Services for IFI27		GenScript Custom Superior Antibodies Services for IFI27
	GenScript Custom overexpressing Cell Line Services for IFI27		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IFI27 promoter
	Search Chromatin IP Primers for IFI27
	RT² qPCR Primer Assay in human, mouse, rat IFI27
	GNC Network for IFI27
	SABiosciences PCR Arrays including human, mouse, rat IFI27

Search Tocris compounds for IFI27

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IFI27 antibodies
	IFI27 proteins
	IFI27 lysates

	Search for Antibodies for IFI27 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IFI27
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

IFI27 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IFI27

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFI27

	SwitchGear 3'UTR luciferase reporter plasmids for IFI27
	SwitchGear Promoter luciferase reporter plasmids for IFI27

Search ThermoFisher Antibodies for IFI27

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IFI27 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

IFI27 Gene

interferon, alpha-inducible protein 27

Aliases
for IFI27 gene

Summaries
for IFI27 gene

Genomic Views
for IFI27 gene

Proteins
for IFI27 gene

Protein Domains /
Families
for IFI27 gene

Function
for IFI27 gene

Pathways & Interactions
for IFI27 gene

Drugs & Compounds
for IFI27 gene

Transcripts
for IFI27 gene

Expression
for IFI27 gene

Orthologs
for IFI27 gene

Paralogs
for IFI27 gene

Genomic Variants
for IFI27 gene

Disorders / Diseases
for IFI27 gene

Publications
for IFI27 gene

External Searches for IFI27 gene

Genome Databases showing IFI27 gene

Other Databases showing IFI27 gene

Specialized Databases showing IFI27 gene

Intellectual Property
for IFI27 gene

Products
for IFI27 gene

View Random Gene

Microsatellite Instability
Retinoblastoma
Pituitary Tumors
GASTRIC TUMOR
Thymoma
dysplasia
aggressiveness
Anaplasia
LUNG CARCINOMA
Atherosclerosis
Metaplasia
Breast Cancer
primary tumor
NSCLC
Adenocarcinoma
Carcinoma Transitional Cell
Cancer
premalignant
Cervical Intraepithelial Neoplasia
Colorectal Carcinoma
Lymphoma
Leukoplakia
mammary tumor
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
Ovarian Cancer
cervical adenocarcinoma
GALLBLADDER CARCINOMA
Papilloma Inverted
squamous cell esophageal cancer
Colorectal Cancer
Burkitt Lymphoma
Smooth Muscle Tumor
carcinoma transitional cell bladder
GLOMERULOSCLEROSIS, FOCAL SEGMENTAL
invasive cancer
Bladder Tumors
aggressive lymphoma
Oral Cancer
Cervical Cancer
MYELOMA
ENDOMETRIAL CARCINOMA
cancer recurrence
prostate cancer
RECTAL CARCINOMA
Tumors
Metastasis
gastrointestinal stromal tumor
prostatic adenocarcinoma
Glioblastoma
Gastric Cancer
BREAST CARCINOMA
Melanoma
Colon Cancer
bladder cancer
ESOPHAGEAL CARCINOMA
Adenoma Follicular
Hyperplasia
Glioma
PITUITARY ADENOMA
Carcinoma
Astrocytoma
Leukemia
PROSTATE CARCINOMA
epithelial tumor
LARYNGEAL CARCINOMA
Tuberous Sclerosis
Carcinoma Papillary
HEPATOCELLULAR CARCINOMA
Laryngeal Cancer
CERVICAL CARCINOMA
metastatic melanoma
THYROID PAPILLARY CARCINOMA
Carcinoma Renal Cell
laryngeal squamous cell carcinoma
Lymphoma High-Grade
Pancreatic Cancer
Cancer Lung
aggressive behavior
Neuroendocrine Tumors
THYROID ADENOMA
Lymphoma B-Cell
Adenocarcinoma Clear Cell
Adenoma
OVARIAN CARCINOMA
Prostatic Intraepithelial Neoplasia
solid tumor
Carcinoma Squamous Cell
Leukoplakia Oral
Carcinoma Embryonal
Endometrial Hyperplasia
leukemogenesis
THYROID CARCINOMA
Endometrial Cancer
Papilloma

Advanced Search

Export list of displayed genes

IFI27 Gene

interferon, alpha-inducible protein 27

Aliasesfor IFI27 gene

Summariesfor IFI27 gene

Genomic Viewsfor IFI27 gene

Proteinsfor IFI27 gene

Protein Domains /Familiesfor IFI27 gene

Functionfor IFI27 gene

Pathways & Interactionsfor IFI27 gene

Drugs & Compoundsfor IFI27 gene

Transcriptsfor IFI27 gene

Expression for IFI27 gene

Orthologsfor IFI27 gene

Paralogsfor IFI27 gene

Genomic Variantsfor IFI27 gene

Disorders / Diseasesfor IFI27 gene

Publicationsfor IFI27 gene

External Searches for IFI27 gene

Genome Databases showing IFI27 gene

Other Databases showing IFI27 gene

Specialized Databases showing IFI27 gene

Intellectual Propertyfor IFI27 gene

Productsfor IFI27 gene

View Random Gene

Aliases
for IFI27 gene

Summaries
for IFI27 gene

Genomic Views
for IFI27 gene

Proteins
for IFI27 gene

Protein Domains /
Families
for IFI27 gene

Function
for IFI27 gene

Pathways & Interactions
for IFI27 gene

Drugs & Compounds
for IFI27 gene

Transcripts
for IFI27 gene

Expression
for IFI27 gene

Orthologs
for IFI27 gene

Paralogs
for IFI27 gene

Genomic Variants
for IFI27 gene

Disorders / Diseases
for IFI27 gene

Publications
for IFI27 gene

Intellectual Property
for IFI27 gene

Products
for IFI27 gene