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Aliases & Descriptions for IFI27
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 2310061N23Rik 2 FAM14D 1 , 2 ISG12 2 ISG12(a) 3 ISG12A 2 P27 1 , 2 p27 3
Descriptions Interferon-alpha-induced 11.5 kDa protein 3 Interferon-stimulated gene 12a protein 3 interferon, alpha-inducible protein 27 2
Search outside databases for aliases for IFI27 genePrevious GC identifers: GC14P092084 GC14P088393 GC14P092567
Summaries for IFI27 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for IFI27
Genomic Location for IFI27
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the IFI27 gene Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32 IFI27 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P093646:
(about GC identifiers )
Start:
93,646,832 bp from pter
End:
93,652,786 bp from pter
Size:
5,955 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for IFI27
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 (See
protein sequence )Recommended Name: Interferon alpha-inducible protein 27 Size : 119 amino acids; 11268 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q53YA6 Q6IEC1 Q96BK3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001123552.1 NP_005523.3 ENSEMBL proteins: ENSP00000298902 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
NAS --
About this table Antibodies for IFI27: Assays for IFI27:
Protein
Domains/ Families for IFI27(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P40305 ProtoNet protein and cluster: P40305
1 Blocks protein family : IPB009311 Interferon-induced 6-16 UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 Similarity : Belongs to the IFI6/IFI27 family
Gene Function for IFI27
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005532 Applied Biosystems Silencer ® siRNAs for IFI27 Sigma-Aldrich siRNA for IFI27 Sigma-Aldrich shRNA for IFI27 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130080                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130080                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC015492  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001130080 UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 Induction : By alpha interferons
Genatlas biochemistry entry for IFI27 :interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
About this table
Pathways & Interactions for IFI27
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for IFI27 --3 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for IFI27 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for IFI27 10/27 Novoseek chemical compound relationships for IFI27 gene (see all 27
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
p00048
49.76
2
9741540 (1)
norcantharidin
48.87
4
16784656 (3), 17287171 (1)
progesterone
38.91
24
16550965 (3), 17015480 (3), 9783852 (2), 17278089 (1) (see all 18 )
bromodeoxyuridine
33.38
2
19029821 (1), 19267931 (1)
thymidine
31.75
5
12421491 (2), 18649995 (1), 16612782 (1)
p002
20.34
5
15646812 (1), 16206298 (1), 16624482 (1), 11552926 (1) (see all 5 )
tyrosine
14.36
17
17908796 (4), 17254966 (3), 18177895 (2), 18710949 (2) (see all 5 )
mnng
11.68
6
11516527 (4), 14728717 (1)
oligonucleotide
9.63
6
12920809 (2), 18950011 (2), 18649995 (1), 10698521 (1)
pd 98,059
9.09
3
16322252 (1), 14992682 (1), 12181740 (1)
About this table
Transcripts for IFI27(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005532 Sigma-Aldrich siRNA for IFI27 Sigma-Aldrich shRNA for IFI27 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001130080 NM_005532
REFSEQ mRNAs for IFI27 gene (2 alternative transcripts): NM_001130080.1 NM_005532.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001130080 NM_005532
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130080                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130080                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC015492  
Additional cDNA sequence: AJ294851.2 AK289535.1 AK312089.1 AY126456.1 AY126457.1 AY126458.1 BC015492.1 BT006781.1 BX647330.1 X67325.1
12 DOTS entries : DT.100827656 DT.97854455 DT.100827644 DT.97854456 DT.100827655 DT.97764309 DT.95330631 DT.120768611 DT.100042157 DT.120768610 DT.91952463 DT.95330627
24/319 AceView cDNA sequences (see all 319
):BU687226 AI799444 BM846153 BM991281 AJ711493 AI285118 BM987761 BQ687647 AW085700 AA132661 CA307308 CD364888 BU185176 BP342779 CD367237 AI814381 BQ052022 CK826087 BQ416830 AU103225 BM756566 CB529359 AW272283 BX281853
highest scoring ESTs for IFI27 :AI991845 X67325 AA062631 AA100091 AA132959 AA143473 AA149021 AA149289 AA157089 AA157813
Unigene Cluster for IFI27: Interferon, alpha-inducible protein 27 Hs.532634 [show with all ESTs ] Unigene Representative Sequence: BQ053892 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 (see all 8
) ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e SP1 :   -         -   -   -     -               SP2 :   -   -       -   -   -     -               SP3 :   -   -   -     -   -   -     -               SP4 :       -     -   -   -     -               SP5 :                   -              
About this scheme ECgene alternative splicing isoforms for IFI27 1 Ensembl transcript including schematic representation : ENST00000298902
Expression for IFI27
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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IFI27 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for IFI27 1 / 2 / 3
4 probe-sets matching IFI27 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCAGGGGAGASOURCE GeneReport for Unigene cluster: Hs.532634 Expression variation in blood from EXPOLDB for IFI27
Orthologs for IFI27
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for IFI27 gene from 4 species
About this table Species with no ortholog for IFI27 ENSEMBL Gene Tree for IFI27 Paralogs for IFI27 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for IFI27 gene IFI27L2 2 IFI6 2 IFI27L1 2
SNPs/Variants for IFI27 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for IFI27 (up to first 250kb)
Disorders & Mutations for IFI27
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600009 10/95 Novoseek disease relationships for IFI27 gene (see all 95
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma
78.83
51
18701138 (3), 10365095 (2), 11221854 (2), 12907249 (2) (see all 44 )
tumors
68.57
383
11237531 (6), 14647411 (6), 11002215 (5), 11679944 (5) (see all 99 )
laryngeal squamous cell carcinoma
56.84
15
12669430 (4), 16116829 (2), 15742257 (1), 10334237 (1) (see all 6 )
cancer
56.39
63
15086558 (2), 15996662 (2), 11038303 (2), 15082919 (2) (see all 39 )
carcinoma squamous cell
54.68
39
17203174 (4), 10738177 (3), 11314778 (3), 14719078 (2) (see all 23 )
breast cancer
54.56
54
10454252 (4), 15082919 (4), 10353599 (3), 10066070 (3) (see all 32 )
carcinoma
54.28
77
17384651 (3), 9160891 (3), 11903577 (3), 17203174 (2) (see all 49 )
laryngeal carcinoma
48.87
5
12669430 (3), 15646812 (1), 10506612 (1)
cervical adenocarcinoma
47.43
5
15337561 (2), 11499840 (1), 10202666 (1), 15041997 (1)
metastasis
46.49
62
11932323 (3), 18925698 (3), 17909030 (2), 12494250 (2) (see all 36 )
About this table Genetic Association Database: IFI27 Human Genome Epidemiology Navigator: IFI27 (3 documents)
Medical News for IFI27 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for IFI27 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/775 PubMed articles for IFI27 gene (see all 775
): Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PubMed id 8358738) 1, 2, 3, 4 Rasmussen U.B.... Basset P. (1993) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762) 3, 6 Saito T....Kawata S. (2004) Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724) 3, 4 Parker N. and Porter A.C.G. (2004) Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas. (PubMed id 14719078) 1, 3 Taguchi T....Tsukuda M. (2004) Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PubMed id 18953482) 3 Mailaparambil B....Heinzmann A. (2008) Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation. (PubMed id 18814951) 3 Takahashi N....Tojo A. (2008) Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. (PubMed id 18361427) 3 Ye Y....Gu J. (2008) Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. (PubMed id 18330707) 3 Rosebeck S. and Leaman D.W. (2008) Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866) 4 Imami K.... Ishihama Y. (2008)
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Genome Databases showing IFI27
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing IFI27
(According to HUGE )
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Specialized Databases showing IFI27 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for IFI27 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for IFI27:
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