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IFI27 Gene

protein-coding   GIFtS: 57
GCID: GC14P094577

Interferon, Alpha-Inducible Protein 27

  See IFI27-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Interferon, Alpha-Inducible Protein 271 2     ISG122
Interferon Alpha-Induced 11.5 KDa Protein2 3     ISG12A2
Interferon-Stimulated Gene 12a Protein2 3     P272
ISG12(a)2 3     Interferon Alpha-Inducible Protein 27, Mitochondrial2
2310061N23Rik2     p273
FAM14D2     

External Ids:    HGNC: 53971   Entrez Gene: 34292   Ensembl: ENSG000001659497   OMIM: 6000095   UniProtKB: P403053   
ORGUL members:    fRNAdb10:FR221825      
H-InvDB12:HIT000250731    
NCBI13:AY126458    
NONCODE14:n334829    
RNAdb15:HIV2649    

Export aliases for IFI27 gene to outside databases

Previous GC identifers: GC14P092084 GC14P088393 GC14P092567 GC14P093646 GC14P074756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFI27 Gene:
IFI27 (interferon, alpha-inducible protein 27) is a protein-coding gene. Diseases associated with IFI27 include encapsulated thymoma, and invasive bladder transitional cell carcinoma. An important paralog of this gene is IFI27L2.

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of
cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9

Gene Wiki entry for IFI27 Gene

fRNAdb sequence ontology for IFI27:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for IFI27

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_018925.2  NT_187601.1  NC_000014.8  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFI27 gene promoter:
         STAT1   HOXA5   STAT1beta   IRF-7A   STAT5A   IRF-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFI27 promoter sequence
   Search Chromatin IP Primers for IFI27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFI27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

IFI27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P094577:  view genomic region     (about GC identifiers)

Start:
94,571,182 bp from pter      End:
94,583,033 bp from pter
Size:
11,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 27, mitochondrial precursor  
Size: 119 amino acids; 11268 Da
Secondary accessions: Q53YA6 Q6IEC1 Q96BK3

Explore the universe of human proteins at neXtProt for IFI27: NX_P40305

Explore proteomics data for IFI27 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFI27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001123552.1  NP_001275881.1  NP_001275883.1  NP_001275885.1  NP_001275886.1  NP_001275887.1  NP_001275888.1  NP_001275889.1  
    NP_001275924.1  NP_005523.3  

    ENSEMBL proteins: 
     ENSP00000451370   ENSP00000450753   ENSP00000452495   ENSP00000451875   ENSP00000298902  
     ENSP00000451987   ENSP00000452560   ENSP00000451956   ENSP00000452012   ENSP00000413536  
     ENSP00000410901  
    Reactome Protein details: P40305

    IFI27 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for IFI27
    OriGene Custom MassSpec
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    Novus Biologicals IFI27 Protein
    Novus Biologicals IFI27 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFI27

     
    Search eBioscience for Proteins for IFI27 

    IFI27 Antibody Products:

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    Abcam antibodies for IFI27
    Cloud-Clone Corp. Antibodies for IFI27
    Search ThermoFisher Antibodies for IFI27
    LSBio Antibodies in human, mouse, rat for IFI27

    IFI27 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFI27
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFI27
    Cloud-Clone Corp. CLIAs for IFI27
    Search eBioscience for ELISAs for IFI27 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009311 IFI6/IFI27

    Graphical View of Domain Structure for InterPro Entry P40305

    ProtoNet protein and cluster: P40305

    1 Blocks protein domain: IPB009311 Interferon-induced 6-16

    UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
    Similarity: Belongs to the IFI6/IFI27 family


    Find genes that share domains with IFI27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFI27_HUMAN, P40305
    Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of
    cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9
    Induction: Up-regulated by interferons

         Genatlas biochemistry entry for IFI27:
    interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with IFI27           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFI27
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFI27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI27
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFI27

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFI27:
    hsa-mir-146a-5p (MIRT021256)

    Block miRNA regulation of human, mouse, rat IFI27 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFI27:
    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidIFI27 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFI27
    Predesigned siRNA for gene silencing in human, mouse, rat IFI27

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFI27

    Clone
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    OriGene clones in human, mouse for IFI27 (see all 17)
    OriGene ORF clones in mouse, rat for IFI27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IFI27 (NM_001130080)
    Sino Biological Human cDNA Clone for IFI27
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IFI27
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFI27 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11387 VA6-11743) for IFI27 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFI27_HUMAN, P40305: Mitochondrion. Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane3
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA18330707
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IFI27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFI27 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43


    Find genes that share SuperPaths with IFI27           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IFI27
        Interferon alpha/beta signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI27: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFI27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFI27 (P403053 ENSP000002989024) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118023, ENSP000002579044I2D: score=2 STRING: ENSP00000257904
    SKP2Q133093, ENSP000002742554I2D: score=1 STRING: ENSP00000274255
    CCND1P243853, ENSP000002275074I2D: score=2 STRING: ENSP00000227507
    PSMC6ENSP000004018024STRING: ENSP00000401802
    PSMC3ENSP000002988524STRING: ENSP00000298852
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA18330707
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0060337type I interferon signaling pathway TAS--
    GO:0097190apoptotic signaling pathway IDA18330707

    Find genes that share ontologies with IFI27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFI27

    Selected Novoseek inferred chemical compound relationships for IFI27 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    optimax 71 1 15385108 (1)
    eb 1089 53.1 13 12408227 (6), 10640426 (2)
    mevastatin 50.6 2 11181044 (1), 12475985 (1)
    roscovitine 49.5 1 8670807 (1)
    p00048 48.7 2 9741540 (1)
    norcantharidin 45.7 4 16784656 (3), 17287171 (1)
    troglitazone 45.4 7 17143939 (2), 11343236 (2), 12595159 (2), 18474441 (1)
    mg 132 44.7 1 17493842 (1)
    estrogen 43 30 17681750 (3), 16601291 (2), 17540032 (1), 10861499 (1) (see all 23)
    hmba 41 9 10597222 (4), 14575541 (2), 17349212 (1), 15182584 (1)



    Find genes that share compounds with IFI27           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for IFI27 gene (10 alternative transcripts): 
    NM_001130080.2  NM_001288952.1  NM_001288954.1  NM_001288956.1  NM_001288957.1  NM_001288958.1  NM_001288959.1  NM_001288960.1  
    NM_001288995.1  NM_005532.4  

    Unigene Cluster for IFI27:

    Interferon, alpha-inducible protein 27
    Hs.532634  [show with all ESTs]
    Unigene Representative Sequence: BQ053892
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554448(uc001ycm.1) ENST00000557098 ENST00000555081 ENST00000557700
    ENST00000554800 ENST00000556544 ENST00000298902 ENST00000555819 ENST00000557634
    ENST00000555744 ENST00000553285 ENST00000557035 ENST00000555121 ENST00000444961
    ENST00000448882(uc001ycn.1 uc021sba.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFI27 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFI27:
    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidIFI27 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFI27
    Predesigned siRNA for gene silencing in human, mouse, rat IFI27
    Clone
    Products:
         
    OriGene clones in human, mouse for IFI27 (see all 17)
    OriGene ORF clones in mouse, rat for IFI27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IFI27 (NM_001130080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFI27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFI27
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFI27
    OriGene qSTAR qPCR primer pairs in human, mouse for IFI27
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFI27
      QuantiTect SYBR Green Assays in human, mouse, rat IFI27
      QuantiFast Probe-based Assays in human, mouse, rat IFI27
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11387 VA6-11743) for IFI27 

    Additional mRNA sequence: 

    AJ294851.2 AK289535.1 AK312089.1 AY126456.1 AY126457.1 AY126458.1 BC015492.1 BT006781.1 
    BX647330.1 X67325.1 

    12 DOTS entries:

    DT.100827656  DT.97854455  DT.100827644  DT.97854456  DT.100827655  DT.97764309  DT.95330631  DT.120768611 
    DT.100042157  DT.120768610  DT.91952463  DT.95330627 

    Selected AceView cDNA sequences (see all 319):

    BM991281 AA938119 CA307308 AU076571 AW085700 BQ687647 AW272283 AJ711493 
    AA157089 CB122858 BQ052022 BM713642 CB123160 BC015492 AI418540 BM987761 
    BP342779 BM846153 AI889225 BM694377 AU098768 BE208583 CA438255 AA309950 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -                       -     -     -           -                                       
    SP2:        -     -                 -     -     -           -                                       
    SP3:        -     -     -           -     -     -           -                                       
    SP4:                    -           -     -     -           -                                       
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for IFI27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFI27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGGGAGA
    IFI27 Expression
    About this image


    IFI27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Gonad
             Primordial Germ Cells Allantois
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
    IFI27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFI27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532634
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI27: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFI27
    OriGene qSTAR qPCR primer pairs in human, mouse for IFI27
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFI27
    QuantiTect SYBR Green Assays in human, mouse, rat IFI27
    QuantiFast Probe-based Assays in human, mouse, rat IFI27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFI27 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifi27l15 interferon, alpha-inducible protein 27 like 1   --   12 (52.93 cM) 103434211 
    chicken
    (Gallus gallus)
    Aves IFI27L26
    Gallus gallus interferon, alpha-inducible protein ...
    52(a)
    1 → many
    23(4295102-4296014)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    22(a)
    many ↔ many
    many ↔ many
    GL343498.1(96838-99481)
    GL343558.1(288340-297430)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1527916
    zgc:1230686
    (see all 7)
    zgc:123068
    (see all 7)
    49(a)
    42(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    13(38014818-38017588) ENSDARG00000039243
    13(38003194-38005739) ENSDARG00000017489


    ENSEMBL Gene Tree for IFI27 (if available)
    TreeFam Gene Tree for IFI27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFI27 gene
    IFI27L22  IFI27L12  
    3 SIMAP similar genes for IFI27 using alignment to 10 protein entries:     IFI27_HUMAN (see all proteins):
    ISG12    IFI27L2    IFI6

    Find genes that share paralogs with IFI27           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFI27 (see all 184)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476409791,2
    C--74754969(+) CATAAA/GTATGG 1 -- us2k10--------
    rs1824853101,2
    --74754978(+) GGACCA/GGGGTG 1 -- us2k10--------
    rs740772131,2
    C,F--74754981(+) CCAGGG/ATGGCC 1 -- us2k13Minor allele frequency- A:0.08WA CSA 122
    rs1487017941,2
    --74755014(+) AAAAAC/GCTGGG 1 -- us2k10--------
    rs1875212041,2
    --74755133(+) GATCCC/TACAGC 1 -- us2k10--------
    rs113294981,2
    C--94575099(+) AACAT-/AAAAAA 1 -- us2k1 trp30--------
    rs1919987351,2
    --94575605(+) ATTGCA/GCCATT 1 -- us2k10--------
    rs101374021,2
    C,F,H--94575708(+) gaaggG/Ccagag 1 -- us2k1 tfbs38Minor allele frequency- C:0.49NS NA WA CSA EA 475
    rs1422257791,2
    C--94575721(+) GGGCAA/GGGAAG 1 -- us2k10--------
    rs1841826711,2
    --94575747(+) AAGGGA/CAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFI27 (94571182 - 94583033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFI27:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34067CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFI27
    DNA2.0 Custom Variant and Variant Library Synthesis for IFI27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600009OMIM information:   
    15 diseases for IFI27:    
    About MalaCards
    encapsulated thymoma    invasive bladder transitional cell carcinoma    maxillary sinus squamous cell carcinoma    extramedullary plasmacytoma
    small cell neuroendocrine carcinoma    gastrointestinal lymphoma    transitional cell carcinoma    endometrial carcinoma
    coronary restenosis    esophageal cancer    oral cancer    gastrointestinal stromal tumor
    follicular thyroid carcinoma    pancreatic cancer    breast cancer


    Find genes that share disorders with IFI27           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFI27 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 78.6 54 18701138 (3), 10365095 (2), 11221854 (2), 12907249 (2) (see all 47)
    tumors 69.1 408 11237531 (6), 14647411 (6), 11002215 (5), 11679944 (5) (see all 99)
    cancer 59.1 69 15086558 (2), 15996662 (2), 11038303 (2), 15082919 (2) (see all 42)
    breast cancer 57.3 60 10454252 (4), 15082919 (4), 10353599 (3), 10066070 (3) (see all 37)
    laryngeal squamous cell carcinoma 54.6 15 12669430 (4), 16116829 (2), 15742257 (1), 10334237 (1) (see all 6)
    carcinoma squamous cell 54.6 39 17203174 (4), 10738177 (3), 11314778 (3), 14719078 (2) (see all 23)
    carcinoma 54.6 83 17384651 (3), 9160891 (3), 11903577 (3), 19447418 (3) (see all 51)
    colon cancer 49 6 19723652 (3), 19505918 (2), 12920809 (1)
    metastasis 47.5 65 11932323 (3), 18925698 (3), 17909030 (2), 12494250 (2) (see all 38)
    laryngeal carcinoma 46.8 5 12669430 (3), 15646812 (1), 10506612 (1)

    Genetic Association Database (GAD): IFI27
    Human Genome Epidemiology (HuGE) Navigator: IFI27 (5 documents)

    Export disorders for IFI27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFI27 gene, integrated from 10 sources (see all 875):
    (articles sorted by number of sources associating them with IFI27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PubMed id 8358738)1, 2, 3, 9 Rasmussen U.B.... Basset P. (Cancer Res. 1993)
    2. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PubMed id 19817957)1, 4 Segat L....Crovella S. (J. Gastroenterol. Hepatol. 2009)
    3. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PubMed id 18953482)1, 4 Mailaparambil B....Heinzmann A. (Arch. Virol. 2008)
    4. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. (PubMed id 18361427)1, 4 Ye Y....Gu J. (Cancer 2008)
    5. Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. (PubMed id 18330707)1, 2 Rosebeck S. and Leaman D.W. (Apoptosis 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (Biochem. Biophys. Res. Commun. 2004)
    8. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (BMC Genomics 2004)
    9. Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas. (PubMed id 14719078)1, 9 Taguchi T....Tsukuda M. (Oncol. Rep. 2004)
    10. The association of IFI27 expression and fatigue intensification during localized radiation therapy: implication of a para-inflammatory bystander response. (PubMed id 23959120)1 Hsiao C.P....Saligan L.N. (Int J Mol Sci 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3429 HGNC: 5397 AceView: IFI27andFAM14B Ensembl:ENSG00000165949 euGenes: HUgn3429
    ECgene: IFI27 H-InvDB: IFI27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFI27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFI27 gene:
    Search GeneIP for patents involving IFI27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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