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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFI27 Gene

protein-coding   GIFtS: 56
GCID: GC14P094577

Interferon, Alpha-Inducible Protein 27

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha-Inducible Protein 271 2     ISG122
Interferon Alpha-Induced 11.5 KDa Protein2 3     ISG12A2
Interferon-Stimulated Gene 12a Protein2 3     P272
ISG12(a)2 3     Interferon Alpha-Inducible Protein 27, Mitochondrial2
2310061N23Rik2     p273
FAM14D2     

External Ids:    HGNC: 53971   Entrez Gene: 34292   Ensembl: ENSG000001659497   OMIM: 6000095   UniProtKB: P403053   

Export aliases for IFI27 gene to outside databases

Previous GC identifers: GC14P092084 GC14P088393 GC14P092567 GC14P093646 GC14P074756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFI27 Gene: 
IFI27 (interferon, alpha-inducible protein 27) is a protein-coding gene. Diseases associated with IFI27 include encapsulated thymoma, and invasive bladder transitional cell carcinoma, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include molecular_function. An important paralog of this gene is IFI27L2.

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of
cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9

Gene Wiki entry for IFI27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFI27 gene promoter:
         STAT1   HOXA5   STAT1beta   IRF-7A   STAT5A   IRF-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFI27 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFI27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFI27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

IFI27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI27 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P094577:  view genomic region     (about GC identifiers)

Start:
94,571,182 bp from pter      End:
94,583,033 bp from pter
Size:
11,852 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 27, mitochondrial precursor  
Size: 119 amino acids; 11268 Da
Subcellular location: Mitochondrion. Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53YA6 Q6IEC1 Q96BK3

Explore the universe of human proteins at neXtProt for IFI27: NX_P40305

Explore proteomics data for IFI27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40305

  • IFI27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFI27 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005523.3  NP_001123552.1  

    ENSEMBL proteins: 
     ENSP00000451370   ENSP00000450753   ENSP00000452495   ENSP00000451875   ENSP00000298902  
     ENSP00000451987   ENSP00000452560   ENSP00000451956   ENSP00000452012   ENSP00000413536  
     ENSP00000410901  
    Reactome Protein details: P40305
    Human Recombinant Protein Products for IFI27: 
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    Novus Biologicals IFI27 Protein
    Novus Biologicals IFI27 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFI27 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA18330707
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral to membrane NAS--

    IFI27 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009311 Interferon-induced_6-16

    Graphical View of Domain Structure for InterPro Entry P40305

    ProtoNet protein and cluster: P40305

    1 Blocks protein domain: IPB009311 Interferon-induced 6-16

    UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
    Similarity: Belongs to the IFI6/IFI27 family


    IFI27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFI27_HUMAN, P40305
    Function: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of
    cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9
    Induction: Up-regulated by interferons

         Genatlas biochemistry entry for IFI27:
    interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    IFI27 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFI27 
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    hsa-miR-942
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFI27 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for IFI27
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    IFI27 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFI27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for IFI27 (P403053 ENSP000002989024) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118023, ENSP000002579044I2D: score=2 STRING: ENSP00000257904
    SKP2Q133093, ENSP000002742554I2D: score=1 STRING: ENSP00000274255
    CCND1P243853, ENSP000002275074I2D: score=2 STRING: ENSP00000227507
    PSMC6ENSP000004018024STRING: ENSP00000401802
    PSMC3ENSP000002988524STRING: ENSP00000298852
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA18330707
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0060337type I interferon-mediated signaling pathway TAS--
    GO:0097190apoptotic signaling pathway IDA18330707

    IFI27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFI27 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFI27

    10/72 Novoseek inferred chemical compound relationships for IFI27 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    optimax 71 1 15385108 (1)
    eb 1089 53.1 13 12408227 (6), 10640426 (2)
    mevastatin 50.6 2 11181044 (1), 12475985 (1)
    roscovitine 49.5 1 8670807 (1)
    p00048 48.7 2 9741540 (1)
    norcantharidin 45.7 4 16784656 (3), 17287171 (1)
    troglitazone 45.4 7 17143939 (2), 11343236 (2), 12595159 (2), 18474441 (1)
    mg 132 44.7 1 17493842 (1)
    estrogen 43 30 17681750 (3), 16601291 (2), 17540032 (1), 10861499 (1) (see all 23)
    hmba 41 9 10597222 (4), 14575541 (2), 17349212 (1), 15182584 (1)

    Search CenterWatch for drugs/clinical trials and news about IFI27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFI27 gene (2 alternative transcripts): 
    NM_005532.3  NM_001130080.1  

    Unigene Cluster for IFI27:

    Interferon, alpha-inducible protein 27
    Hs.532634  [show with all ESTs]
    Unigene Representative Sequence: BQ053892
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554448(uc001ycm.1) ENST00000557098 ENST00000555081 ENST00000557700
    ENST00000554800 ENST00000556544 ENST00000298902 ENST00000555819 ENST00000557634
    ENST00000555744 ENST00000553285 ENST00000557035 ENST00000555121 ENST00000444961
    ENST00000448882(uc001ycn.1 uc021sba.1)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IFI27:
    hsa-miR-942
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFI27

    Additional mRNA sequence: 

    AJ294851.2 AK289535.1 AK312089.1 AY126456.1 AY126457.1 AY126458.1 BC015492.1 BT006781.1 
    BX647330.1 X67325.1 

    12 DOTS entries:

    DT.100827656  DT.97854455  DT.100827644  DT.97854456  DT.100827655  DT.97764309  DT.95330631  DT.120768611 
    DT.100042157  DT.120768610  DT.91952463  DT.95330627 

    24/319 AceView cDNA sequences (see all 319):

    BM841506 CD364888 AI799444 CB104733 AW272283 AI418540 AI814381 BM694377 
    CB120861 CA438255 BT006781 BM714735 BM998410 CD367237 BM840473 BU631080 
    AW473943 BX281853 BM838606 BU730574 BM756566 AU076571 AW085700 AA157089 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -                       -     -     -           -                                       
    SP2:        -     -                 -     -     -           -                                       
    SP3:        -     -     -           -     -     -           -                                       
    SP4:                    -           -     -     -           -                                       
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for IFI27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFI27 expression in normal human tissues (normalized intensities)      IFI27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGGGAGA
    IFI27 Expression
    About this image


    IFI27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 10 entries
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Fibroblast
             Human Ovarian Fibroblasts (HOF)   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             Human Dermal Microvascular Endothelial Cells (HDMEC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Epiphyseal End
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See IFI27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFI27

    SOURCE GeneReport for Unigene cluster: Hs.532634
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFI27: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFI27 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifi27l11 , 5 interferon, alpha-inducible protein 27 like 11, 5 63.94(n)1
    59.09(a)1
      12 (52.93 cM)5
    526681  NM_194067.21  NP_919043.11 
     1034342115 
    chicken
    (Gallus gallus)
    Aves IFI27L26
    interferon alpha-inducible protein 27-like protein...
    51(a)
    1 → many
    23(4295102-4296014)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    22(a)
    many ↔ many
    many ↔ many
    GL343498.1(96838-99481)
    GL343558.1(288340-297430)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1527916
    zgc:1230686
    (see all 8)
    zgc:123068
    (see all 8)
    47(a)
    42(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    13(38014818-38017588)
    13(38003194-38005739)


    ENSEMBL Gene Tree for IFI27 (if available)
    TreeFam Gene Tree for IFI27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFI27 gene
    IFI27L22  IFI62  IFI27L12  
    3 SIMAP similar genes for IFI27 using alignment to 10 protein entries:     IFI27_HUMAN (see all proteins):
    ISG12    IFI27L2    IFI6

    IFI27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/184 SNPs in IFI27 are shown (see all 184)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476409791,2
    C--74754969(+) CATAAA/GTATGG 1 -- us2k10--------
    rs1824853101,2
    --74754978(+) GGACCA/GGGGTG 1 -- us2k10--------
    rs740772131,2
    C,F--74754981(+) CCAGGG/ATGGCC 1 -- us2k13Minor allele frequency- A:0.08WA CSA 122
    rs1487017941,2
    --74755014(+) AAAAAC/GCTGGG 1 -- us2k10--------
    rs1875212041,2
    --74755133(+) GATCCC/TACAGC 1 -- us2k10--------
    rs113294981,2
    C--94575099(+) AACAT-/AAAAAA 1 -- us2k1 trp30--------
    rs1919987351,2
    --94575605(+) ATTGCA/GCCATT 1 -- us2k10--------
    rs101374021,2
    C,F,H--94575708(+) gaaggG/Ccagag 1 -- us2k1 tfbs38Minor allele frequency- C:0.49NS NA WA CSA EA 475
    rs1422257791,2
    C--94575721(+) GGGCAA/GGGAAG 1 -- us2k10--------
    rs1841826711,2
    --94575747(+) AAGGGA/CAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFI27 (94571182 - 94583033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IFI27:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34067CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600009    OMIM disorders: --

    20/110 diseases for IFI27 (see all 110):    About MalaCards
    encapsulated thymoma    invasive bladder transitional cell carcinoma    maxillary sinus squamous cell carcinoma    extramedullary plasmacytoma
    bladder transitional cell carcinoma    gastrointestinal lymphoma    leukoplakia    richter's syndrome
    thymoma    oral leukoplakia    transitional cell carcinoma    cervical adenocarcinoma
    laryngeal carcinoma    adenocarcinoma in situ    coronary restenosis    laryngitis
    inverted papilloma    smooth muscle tumor    papilloma    thymic epithelial tumor


    IFI27 for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for IFI27 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 78.6 54 18701138 (3), 10365095 (2), 11221854 (2), 12907249 (2) (see all 47)
    tumors 69.1 408 11237531 (6), 14647411 (6), 11002215 (5), 11679944 (5) (see all 99)
    cancer 59.1 69 15086558 (2), 15996662 (2), 11038303 (2), 15082919 (2) (see all 42)
    breast cancer 57.3 60 10454252 (4), 15082919 (4), 10353599 (3), 10066070 (3) (see all 37)
    laryngeal squamous cell carcinoma 54.6 15 12669430 (4), 16116829 (2), 15742257 (1), 10334237 (1) (see all 6)
    carcinoma squamous cell 54.6 39 17203174 (4), 10738177 (3), 11314778 (3), 14719078 (2) (see all 23)
    carcinoma 54.6 83 17384651 (3), 9160891 (3), 11903577 (3), 19447418 (3) (see all 51)
    colon cancer 49 6 19723652 (3), 19505918 (2), 12920809 (1)
    metastasis 47.5 65 11932323 (3), 18925698 (3), 17909030 (2), 12494250 (2) (see all 38)
    laryngeal carcinoma 46.8 5 12669430 (3), 15646812 (1), 10506612 (1)

    Genetic Association Database (GAD): IFI27
    Human Genome Epidemiology (HuGE) Navigator: IFI27 (5 documents)

    Export disorders for IFI27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFI27 gene, integrated from 9 sources (see all 868):
    (articles sorted by number of sources associating them with IFI27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PubMed id 8358738)1, 2, 3, 9 Rasmussen U.B.... Basset P. (1993)
    2. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients . (PubMed id 19817957)1, 4 Segat L....Crovella S. (2009)
    3. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PubMed id 18953482)1, 4 Mailaparambil B....Heinzmann A. (2008)
    4. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. (PubMed id 18361427)1, 4 Ye Y....Gu J. (2008)
    5. Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. (PubMed id 18330707)1, 2 Rosebeck S. and Leaman D.W. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    8. Identification of a novel gene family that includes the interferon- inducible human genes 6-16 and ISG12. (PubMed id 14728724)1, 2 Parker N. and Porter A.C.G. (2004)
    9. Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas. (PubMed id 14719078)1, 9 Taguchi T....Tsukuda M. (2004)
    10. The interferon stimulated gene 12 inactivates vasculop rotective functions of NR4A nuclear receptors. (PubMed id 22427340)1 Papac-Milicevic N....Binder B.R. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3429 HGNC: 5397 AceView: IFI27andFAM14B Ensembl:ENSG00000165949 euGenes: HUgn3429
    ECgene: IFI27 H-InvDB: IFI27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFI27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFI27 gene:
    Search GeneIP for patents involving IFI27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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