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IFI27 Gene

protein-coding   GIFtS: 57

GC14P093646
interferon, alpha-inducible protein 27
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
2310061N23Rik 2
FAM14D 1, 2
ISG12 2
ISG12(a) 3
ISG12A 2
P27 1, 2
p27 3
Descriptions
Interferon-alpha-induced 11.5 kDa protein 3
Interferon-stimulated gene 12a protein 3
interferon, alpha-inducible protein 27 2
External Ids
HGNC: 53971
Entrez Gene: 34292
UniProtKB: P403053
Ensembl: ENSG000001659497
Search outside databases for aliases for IFI27 gene

Previous GC identifers: GC14P092084 GC14P088393 GC14P092567

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for IFI27
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFI27 gene  

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32

IFI27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P093646:     (about GC identifiers)

Start:
93,646,832 bp from pter
End:
93,652,786 bp from pter
Size:
5,955 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305 (See protein sequence)
Recommended Name: Interferon alpha-inducible protein 27  
Size: 119 amino acids; 11268 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53YA6 Q6IEC1 Q96BK3

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001123552.1  NP_005523.3  


    ENSEMBL proteins: 
    ENSP00000298902 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (IFI27)
    Human Recombinant Proteins from Abnova (IFI27)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane NAS--
    About this table

    Antibodies for IFI27: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IFI27
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (IFI27), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (IFI27)
    Novus Biologicals Antibodies for IFI27

    Assays for IFI27: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR009311 Interferon-induced_6-16


       GeneDecks  IFI27 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P40305

    ProtoNet protein and cluster: P40305

    1 Blocks protein family: IPB009311 Interferon-induced 6-16

    UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
    Similarity: Belongs to the IFI6/IFI27 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (IFI27)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFI27)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005532

                  Applied Biosystems Silencer® siRNAs for IFI27

                  Sigma-Aldrich siRNA for IFI27  
                         Sigma-Aldrich shRNA for IFI27  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IFI27
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130080
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130080
                                     untagged cDNA clones in CMV expression vector (see all 3): BC015492 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001130080

    UniProtKB/Swiss-Prot: IFI27_HUMAN, P40305
    Induction: By alpha interferons

    Genatlas biochemistry entry for IFI27:
    interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  IFI27 

      --

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007568 aging IEA--
    GO:0008150 biological_process ND--
    GO:0009615 response to virus IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IFI27
    10/27 Novoseek chemical compound relationships for IFI27 gene (see all 27 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    p00048 49.76 2 9741540 (1)
    norcantharidin 48.87 4 16784656 (3), 17287171 (1)
    progesterone 38.91 24 16550965 (3), 17015480 (3), 9783852 (2), 17278089 (1) (see all 18)
    bromodeoxyuridine 33.38 2 19029821 (1), 19267931 (1)
    thymidine 31.75 5 12421491 (2), 18649995 (1), 16612782 (1)
    p002 20.34 5 15646812 (1), 16206298 (1), 16624482 (1), 11552926 (1) (see all 5)
    tyrosine 14.36 17 17908796 (4), 17254966 (3), 18177895 (2), 18710949 (2) (see all 5)
    mnng 11.68 6 11516527 (4), 14728717 (1)
    oligonucleotide 9.63 6 12920809 (2), 18950011 (2), 18649995 (1), 10698521 (1)
    pd 98,059 9.09 3 16322252 (1), 14992682 (1), 12181740 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (IFI27)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFI27)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005532

                  Sigma-Aldrich siRNA for IFI27  
                         Sigma-Aldrich shRNA for IFI27  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001130080  NM_005532  

    REFSEQ mRNAs for IFI27 gene (2 alternative transcripts): 

    NM_001130080.1   NM_005532.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001130080  NM_005532  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130080
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130080
                                     untagged cDNA clones in CMV expression vector (see all 3): BC015492 

    Additional cDNA sequence: 

    AJ294851.2 AK289535.1 AK312089.1 AY126456.1 AY126457.1 AY126458.1 BC015492.1 BT006781.1 
    BX647330.1 X67325.1 

    12 DOTS entries:

    DT.100827656  DT.97854455  DT.100827644  DT.97854456  DT.100827655  DT.97764309  DT.95330631  DT.120768611 
    DT.100042157  DT.120768610  DT.91952463  DT.95330627 

    24/319 AceView cDNA sequences (see all 319 ):

    BU687226 AI799444 BM846153 BM991281 AJ711493 AI285118 BM987761 BQ687647 
    AW085700 AA132661 CA307308 CD364888 BU185176 BP342779 CD367237 AI814381 
    BQ052022 CK826087 BQ416830 AU103225 BM756566 CB529359 AW272283 BX281853 

    highest scoring ESTs for IFI27:

    AI991845 X67325 AA062631 AA100091 AA132959 AA143473 AA149021 AA149289 AA157089 AA157813 

    Unigene Cluster for IFI27:

    Interferon, alpha-inducible protein 27
    Hs.532634  [show with all ESTs]
    Unigene Representative Sequence: BQ053892


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 (see all 8 )

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -                       -     -     -           -                                       
    SP2:        -     -                 -     -     -           -                                       
    SP3:        -     -     -           -     -     -           -                                       
    SP4:                    -           -     -     -           -                                       
    SP5:                                                        -                                       

    About this scheme

    ECgene alternative splicing isoforms for IFI27

    1 Ensembl transcript including schematic representation:
    ENST00000298902  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IFI27 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IFI27

    1 / 2 / 3

    4 probe-sets matching IFI27 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    425_at2, 3 U95-A 1 1.00 1.00 0.98 0.91 X67325 1.00 1.00 1.00 1

    48864_at2, 3 U95-B 2 1.00 0.94 0.98 1.09 AI991845 1.00 1.00 1.00 1

    202411_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005532 0.60 1.00 0.82 1

    202411_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  IFI27 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCAGGGGAGA

    SOURCE GeneReport for Unigene cluster: Hs.532634

    Expression variation in blood from EXPOLDB for IFI27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for IFI27 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    LOC4532501   -- similar to putative ISG12(a) protein 98.6(n)
    97.48(a)
    453250  XM_001152160.1  XP_001152160.1 
    cow
    (Bos taurus)
    ISG12(A)1   -- similar to putative ISG12(a) protein 64.9(n)
    53.98(a)
    507138  NM_001038050.1  NP_001033139.1 
    rat
    (Rattus norvegicus)
    Ifi27l1   -- interferon, alpha-inducible protein 27-like 67.57(n)
    57.66(a)
    170512  NM_130743.1  NP_570099.1 
    mouse
    (Mus musculus)
    D12Ertd647e1   -- DNA segment, Chr 12, ERATO Doi 647, expressed 64.24(n)
    59.09(a)
    52668  NM_194067.1  NP_919043.1 
    About this table        Species with no ortholog for IFI27

    ENSEMBL Gene Tree for IFI27
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IFI27 gene
    IFI27L22  IFI62  IFI27L12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/41 NCBI SNPs in IFI27 are shown (see all 41 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 62)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22279741,2
    C,F,H,O93652574(+) GGGCTC/TCATTG 2 S/F mis116Minor allele frequency- T:0.07MN EU EA WA NA 1448
    rs38148211,2
    A,C,F,H93646690(-) CCAGAG/AGAAAA 1 -- ng5115Minor allele frequency- A:0.16EA MN EU WA 3076
    rs12430811,2
    C,F,O93653215(+) AACCCC/TGCGCA 1 -- ng314Minor allele frequency- T:0.15MN NA 326
    rs27991,2
    C,F,H93652679(+) CCATCC/GTGACC 2 -- ut3117Minor allele frequency- G:0.33MN NA EA EU WA 2984
    rs171294791,2
    F,H93652877(+) GAAACG/ACGTTC 1 -- ng317Minor allele frequency- A:0.01NA EU EA WA 556
    --
    rs101374021,2
    F,H93645461(+) gaaggC/Gcagag 1 -- ng51 tfbs31Minor allele frequency- G:0.38WA 110
    --
    rs38335071,2
    C93651883(-) CAGCC-/GCC   
      ATGGCC
    ACAAC
    2 A/GPWP V/GPWL fra10--------
    rs10429511,2
    A,F,H93652611(+) AGGTTC/TTACTA 2 F/F syn1 ese38Minor allele frequency- T:0.01NA EA MN EU WA 854
    rs22396451,2
    A,C,F,H93651038(+) TTGGGG/AAGCAG 1 -- int19Minor allele frequency- A:0.32EA EU WA 2322
    rs80079821,2
    A,C,F,H93649952(+) TCTCTT/CTACTT 1 -- int11Minor allele frequency- C:0.07WA 104
    About this table

    HapMap Linkage Disequilibrium images for IFI27 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 600009

    10/95 Novoseek disease relationships for IFI27 gene (see all 95 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 78.83 51 18701138 (3), 10365095 (2), 11221854 (2), 12907249 (2) (see all 44)
    tumors 68.57 383 11237531 (6), 14647411 (6), 11002215 (5), 11679944 (5) (see all 99)
    laryngeal squamous cell carcinoma 56.84 15 12669430 (4), 16116829 (2), 15742257 (1), 10334237 (1) (see all 6)
    cancer 56.39 63 15086558 (2), 15996662 (2), 11038303 (2), 15082919 (2) (see all 39)
    carcinoma squamous cell 54.68 39 17203174 (4), 10738177 (3), 11314778 (3), 14719078 (2) (see all 23)
    breast cancer 54.56 54 10454252 (4), 15082919 (4), 10353599 (3), 10066070 (3) (see all 32)
    carcinoma 54.28 77 17384651 (3), 9160891 (3), 11903577 (3), 17203174 (2) (see all 49)
    laryngeal carcinoma 48.87 5 12669430 (3), 15646812 (1), 10506612 (1)
    cervical adenocarcinoma 47.43 5 15337561 (2), 11499840 (1), 10202666 (1), 15041997 (1)
    metastasis 46.49 62 11932323 (3), 18925698 (3), 17909030 (2), 12494250 (2) (see all 36)
    About this table

    Genetic Association Database: IFI27
    Human Genome Epidemiology Navigator: IFI27 (3 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/775 PubMed articles for IFI27 gene (see all 775 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 3429 HGNC: 5397 AceView: IFI27andFAM14B Ensembl:ENSG00000165949 euGenes: HUgn3429
    ECgene: IFI27 H-InvDB: IFI27
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IFI27:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for IFI27 Antibodies for IFI27
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