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IFI16 Gene

protein-coding   GIFtS: 61
GCID: GC01P158969

Interferon, Gamma-Inducible Protein 16

  Search for IFI16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Gamma-Inducible Protein 161 2     Gamma-Interferon-Inducible Protein 162
Interferon-Inducible Myeloid Differentiation Transcriptional Activator2 3     Interferon-Gamma Induced Protein IFI 162
IFNGIP12 3     Ifi-163
PYHIN22     

External Ids:    HGNC: 53951   Entrez Gene: 34282   Ensembl: ENSG000001635657   OMIM: 1475865   UniProtKB: Q166663   

Export aliases for IFI16 gene to outside databases

Previous GC identifers: GC01P156771 GC01P154702 GC01P155747 GC01P156196 GC01P155782 GC01P157236 GC01P130336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFI16 Gene:
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid
repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional
regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and
interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf
signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Apr 2011)

GeneCards Summary for IFI16 Gene:
IFI16 (interferon, gamma-inducible protein 16) is a protein-coding gene. GO annotations related to this gene include double-stranded DNA binding and transcription factor binding. An important paralog of this gene is AIM2.

UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666
Function: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems
to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in
the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular
proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the
retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53
sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in
energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be
involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of
prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and
probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the
induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome,
probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's
sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome
formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV)
probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors

Gene Wiki entry for IFI16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFI16 gene promoter:
         STAT1   Sp1   AP-1   ATF-2   STAT1beta   STAT5A   STAT1alpha   AREB6   CP2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFI16 promoter sequence
   Search Chromatin IP Primers for IFI16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFI16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22

IFI16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFI16 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158969:  view genomic region     (about GC identifiers)

Start:
158,969,758 bp from pter      End:
159,024,945 bp from pter
Size:
55,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666 (See protein sequence)
Recommended Name: Gamma-interferon-inducible protein 16  
Size: 785 amino acids; 88256 Da
Subunit: Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3. Interacts
with TMEM173, AIM2, PYCARD and CASP1. Interacts with BRCA1, TP53, E2F1, RB1 and SP1
Sequence caution: Sequence=AAF20997.1; Type=Frameshift; Positions=776; Sequence=AAF20997.1; Type=Miscellaneous
discrepancy; Note=Intron retention; Sequence=BAC04462.1; Type=Miscellaneous discrepancy; Note=Probable cloning
artifact; Sequence=BAD92226.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAG58950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from and Proteopedia for IFI16:
2OQ0 (3D)        3B6Y (3D)        3RLN (3D)        3RLO (3D)        3RNU (3D)    
Secondary accessions: B4DJT8 H3BLV7 Q59GX0 Q5T3W7 Q5T3W8 Q5T3X0 Q5T3X1 Q5T3X2 Q8N9E5 Q8NEQ7
Q96AJ5 Q9UH78
Alternative splicing: 4 isoforms:  Q16666-1   Q16666-2   Q16666-3   Q16666-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IFI16: NX_Q16666

Explore proteomics data for IFI16 at MOPED

Post-translational modifications: 

  • Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location. In
    vitro can be acetylated by p300/EP300 coupled to cytoplasmic localization1
  • Phosphorylated on Ser and Thr1
  • Isoform 3 seems to show a minor degree of complex carbohydrate addition1
  • Ubiquitination2 at Lys128, Lys143, Lys190, Lys614, Lys743
  • Modification sites at PhosphoSitePlus

  • See IFI16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193496.1  NP_005522.2  

    ENSEMBL proteins: 
     ENSP00000458084   ENSP00000406406   ENSP00000407052   ENSP00000357113   ENSP00000357114  
     ENSP00000295809   ENSP00000352740   ENSP00000404325   ENSP00000456094   ENSP00000456129  
     ENSP00000394935   ENSP00000342741  
    Reactome Protein details: Q16666

    IFI16 Human Recombinant Protein Products:

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    Novus Biologicals IFI16 Proteins
    Novus Biologicals IFI16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFI16

     
    Search eBioscience for Proteins for IFI16 

    IFI16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for IFI16
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    LSBio Antibodies in human, mouse, rat for IFI16

    IFI16 Assay Products:

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    Cloud-Clone Corp. ELISAs for IFI16
    Cloud-Clone Corp. CLIAs for IFI16
    Search eBioscience for ELISAs for IFI16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004021 HIN200/IF120x
     IPR012340 NA-bd_OB-fold
     IPR004020 DAPIN

    Graphical View of Domain Structure for InterPro Entry Q16666

    ProtoNet protein and cluster: Q16666

    2 Blocks protein domains:
    IPB004020 Pyrin domain
    IPB004021 HIN-200/IF120x domain


    UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666
    Domain: The HIN-20 domains mediates dsDNA binding via electrostatic interactions (PubMed:22483801)
    Similarity: Belongs to the HIN-200 family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 2 HIN-200 domains


    Find genes that share domains with IFI16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF16_HUMAN, Q16666
    Function: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems
    to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in
    the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular
    proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the
    retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53
    sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in
    energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be
    involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of
    prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and
    probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the
    induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome,
    probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's
    sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome
    formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV)
    probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors
    Induction: Strongly induced by IFNG/IFN-gamma and, to a lesser extent, by alpha interferon. In HL-60 cells,
    maximum induction by IFNG/IFN-gamma occurs within 12 hours whereas, for IFN-alpha, only 10-fold induction was
    observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3.
    Induced in monocytes by IFN-alpha and viral dsDNA. Induced by glucose restriction

         Genatlas biochemistry entry for IFI16:
    nuclear protein,constitutively expressed in lymphocytes,interferon alpha or gamma inducible in myeloid cells
    (clone IFI-6-16)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA7536752
    GO:0005515protein binding IPI11146555
    GO:0008134transcription factor binding IDA12894224
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with IFI16           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IFI16:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFI16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFI16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFI16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFI16

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFI16:
    hsa-mir-335-5p (MIRT017847), hsa-mir-98-5p (MIRT027519), hsa-mir-26b-5p (MIRT029441), hsa-mir-124-3p (MIRT022657)

    Block miRNA regulation of human, mouse, rat IFI16 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFI16:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidIFI16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFI16
    Predesigned siRNA for gene silencing in human, mouse, rat IFI16

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for IFI16 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IFI16 (NM_005531)
    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for IFI16 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFI16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF16_HUMAN, Q16666: Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the
    multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA14654789
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IFI16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFI16 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    IRF3-mediated induction of type I IFN0.00
    STING mediated induction of host immune responses0.00
    2Senescence and Autophagy
    Senescence and Autophagy
    3NF-kappaB Signaling
    NF-kappaB Signaling
    4Id Signaling Pathway
    Id Signaling Pathway


    Find genes that share SuperPaths with IFI16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IFI16
        NF-kappaB Signaling

    2 BioSystems Pathways for IFI16
        Senescence and Autophagy
    Id Signaling Pathway

    2 Reactome Pathways for IFI16
        STING mediated induction of host immune responses
    IRF3-mediated induction of type I IFN


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI16: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFI16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFI16 (Q166661, 2, 3 ENSP000003571134) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 2, 3, ENSP000003638224EBI-2867186,EBI-608057 MINT-1781599 MINT-1781673 MINT-1781653 I2D: score=2 STRING: ENSP00000363822
    TP53P046371, 3, ENSP000002693054EBI-6273540,EBI-366083 I2D: score=3 STRING: ENSP00000269305
    BRCA1P383981, 3, ENSP000003502834EBI-2867186,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    TMEM173Q86WV61, 3, ENSP000003312884EBI-2867186,EBI-2800345 I2D: score=2 STRING: ENSP00000331288
    ID3Q025353, ENSP000003636894I2D: score=2 STRING: ENSP00000363689
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0001819positive regulation of cytokine production TAS--
    GO:0002218activation of innate immune response IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with IFI16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFI16 (IF16)

    3 Novoseek inferred chemical compound relationships for IFI16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mnda 97.8 17 7536752 (4), 11215814 (3), 19762380 (2), 10828447 (1) (see all 11)
    p202 94.3 2 18598717 (1), 9642285 (1)
    physostigmine 67.6 2 11215814 (1), 9642285 (1)



    Find genes that share compounds with IFI16           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFI16 gene (2 alternative transcripts): 
    NM_001206567.1  NM_005531.2  

    Unigene Cluster for IFI16:

    Interferon, gamma-inducible protein 16
    Hs.380250  [show with all ESTs]
    Unigene Representative Sequence: NM_005531
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566111 ENST00000426592 ENST00000447473 ENST00000368131(uc010pit.2)
    ENST00000368132(uc001ftg.3) ENST00000493884 ENST00000483916 ENST00000295809(uc010pis.2)
    ENST00000359709 ENST00000448393 ENST00000567661 ENST00000474473 ENST00000562225
    ENST00000430894 ENST00000340979(uc001ftf.1)
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    1 qRT-PCR Assays for microRNA that regulate IFI16:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidIFI16 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): IFI16 (NM_005531)
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    Addgene plasmids for IFI16 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IFI16
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFI16
      QuantiTect SYBR Green Assays in human, mouse, rat IFI16
      QuantiFast Probe-based Assays in human, mouse, rat IFI16

    Additional mRNA sequence: 

    AB208989.1 AF086545.1 AK296228.1 AK307957.1 AY138863.1 BC017059.1 M63838.1 

    18 DOTS entries:

    DT.417806  DT.448189  DT.97859254  DT.92443457  DT.100822067  DT.100822075  DT.100034821  DT.99982594 
    DT.121449325  DT.121449318  DT.121449368  DT.99950181  DT.417808  DT.100720178  DT.100822071  DT.40248264 
    DT.40311625  DT.121449307 

    Selected AceView cDNA sequences (see all 403):

    AW408127 BQ448467 BG434340 AY185346 BP345706 BX956430 BF058420 AI888019 
    CR620182 BQ004288 AA169187 AA593188 BE843017 BG253409 AI431953 AA885017 
    BX956130 CA442332 AA382682 BQ008879 BU674440 AK094968 BQ005817 BU618394 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFI16 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                      -                     
    SP3:                                                                                                                                -     -                     
    SP4:                                                                                                                                                            
    SP5:                    -           -                                                                                                                           

    ExUns: 15a · 15b · 15c ^ 16a · 16b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for IFI16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFI16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGACTGAC
    IFI16 Expression
    About this image


    IFI16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
    IFI16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFI16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380250

    UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666
    Tissue specificity: Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid
    precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and
    polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFI16: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IFI16 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifi2045
    Pydc41
    interferon activated gene 2045
    pyrin domain containing 41
    65.77(n)1
    57.14(a)1
      1 (80.63 cM)5
    6231211  NM_001177349.11  NP_001170820.11 
     1737472935 


    ENSEMBL Gene Tree for IFI16 (if available)
    TreeFam Gene Tree for IFI16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFI16 gene
    AIM22  PYHIN12  MNDA2  
    3 SIMAP similar genes for IFI16 using alignment to 7 protein entries:     IF16_HUMAN (see all proteins):
    PYHIN1    MNDA    AIM2

    Find genes that share paralogs with IFI16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFI16 (see all 1195)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005544061,2
    C--130341555(+) GAATA-/ATTTCTTA 2 -- int10--------
    rs724802491,2
    C--130341557(+) ATAATT/ATCTTA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs345402011,2
    C--158980926(+) GTACTT/-TTGGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs675885051,2
    C--158981173(+) GTCTC-/AAAAAA 2 -- int10--------
    rs354879341,2
    C--158981187(+) AAAAAT/ATTTTT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1445227141,2
    C--158981457(+) TTATC-/AT    
       T
    /TAT
    ATGTG
    4 -- cds10--------
    rs559043191,2
    C--158981459(+) ATCATTAT/-GTGGT 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs114032861,2
    C--158981901(+) ATTCAT/-TGTTT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs597642531,2
    C--158982953(+) TTTTT-/TTGACGG 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs590809401,2
    C--158984188(+) ACTGA-/AGG   
      C
    /GGCA
    GGCAA
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for IFI16 (158969758 - 159024945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IFI16 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718684CNV Deletion23290073
    esv2718696CNV Deletion23290073
    nsv506961CNV Insertion20534489
    nsv825032CNV Loss20364138
    esv33763CNV Loss17666407
    esv32912CNV Loss17666407
    esv6708CNV Loss19470904
    nsv825019CNV Loss20364138
    nsv872486CNV Loss21882294
    nsv3176CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFI16
    DNA2.0 Custom Variant and Variant Library Synthesis for IFI16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147586    OMIM disorders: --


    Find genes that share disorders with IFI16           About GenesLikeMe

    4 Novoseek inferred disease relationships for IFI16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 38.7 1 17911419 (1)
    melanoma 28.1 3 9642285 (1), 14757431 (1), 20187706 (1)
    cancer 2.15 1 17981573 (1)
    tumors 0 15 17569615 (4), 19553003 (4), 18231640 (1), 19338980 (1)

    Genetic Association Database (GAD): IFI16
    Human Genome Epidemiology (HuGE) Navigator: IFI16 (3 documents)

    Export disorders for IFI16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFI16 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with IFI16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. (PubMed id 7959953)1, 2, 3, 9 Trapani J.A.... Browne K.A. (Immunogenetics 1994)
    2. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. (PubMed id 1526658)1, 2, 3, 9 Trapani J.A.... Dupont B. (Immunogenetics 1992)
    3. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. (PubMed id 7536752)1, 2, 9 Dawson M.J. and Trapani J.A. (J. Cell. Biochem. 1995)
    4. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. (PubMed id 12894224)1, 2, 9 Xin H.... Choubey D. (Oncogene 2003)
    5. The human interferon-inducible protein, IFI 16, is a repressor of transcription. (PubMed id 9642285)1, 2, 9 Johnstone R.W.... Trapani J.A. (J. Biol. Chem. 1998)
    6. Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. (PubMed id 9718316)1, 2, 9 Johnstone R.W.... Trapani J.A. (Biochemistry 1998)
    7. Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. (PubMed id 22618232)1, 2 Brazda V.... Arrowsmith C.H. (Biochem. Biophys. Res. Commun. 2012)
    8. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. (PubMed id 22483801)1, 2 Jin T.... Xiao T.S. (Immunity 2012)
    9. Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. (PubMed id 22691496)1, 2 Li T.... Cristea I.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. (PubMed id 22291595)1, 2 Gariano G.R.... Landolfo S. (PLoS Pathog. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3428 HGNC: 5395 AceView: IFI16andIFIX Ensembl:ENSG00000163565 euGenes: HUgn3428
    ECgene: IFI16 H-InvDB: IFI16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFI16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFI16 gene:
    Search GeneIP for patents involving IFI16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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