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IFI16 Gene

protein-coding GIFtS: 59

GC01P157236

interferon, gamma-inducible protein 16
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
IFNGIP1 ^¹, ², ³
MGC9466 ^²
OTTHUMP00000035192 ^²
PYHIN2 ^¹, ²

Descriptions
IFI 16 ^³
Interferon-inducible myeloid differentiation transcriptional activator ^², ³
interferon, gamma-inducible protein 16 ^²
interferon-gamma induced protein IFI 16 ^²

External Ids
HGNC: 5395¹
Entrez Gene: 3428²
UniProtKB: Q16666³
Ensembl: ENSG00000163565⁷

Search outside databases for aliases for IFI16 gene

Previous GC identifers: GC01P156771 GC01P154702 GC01P155747 GC01P156196 GC01P155782

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFI16:

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with

200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA

binding, transcriptional regulation, and protein-protein interactions. The protein localizes to

the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53

function, and inhibits cell growth in the Ras/Raf signaling pathway. [provided by RefSeq]

UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666

Function: May function as a transcriptional repressor. Could have a role in the regulation of

hematopoeitic differentiation through activation of unknown target genes. Controls cellular

proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and

the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells

Gene Wiki entry for IFI16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFI16 gene

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q22

IFI16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P157236: (about GC identifiers)

Start:	157,236,382 bp from pter
End:	157,291,569 bp from pter
Size:	55,188 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666 (See protein sequence)

Recommended Name: Gamma-interferon-inducible protein Ifi-16

Size: 785 amino acids; 88256 Da

Subunit: Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded

DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein

Subcellular location: Nucleus

Sequence caution: Sequence=AAF20997.1; Type=Frameshift; Positions=776; Sequence=AAF20997.1;

Type=Miscellaneous discrepancy; Note=Intron retention;

PDB structure from and Proteopedia :

2OQ0 (3D)

3B6Y (3D)

Secondary accessions: Q59GX0 Q5T3W7 Q5T3W8 Q5T3X0 Q5T3X1 Q5T3X2 Q8N9E5 Q8NEQ7 Q96AJ5 Q9UH78

Alternative splicing: 4 isoforms: Q16666-1 Q16666-2 Q16666-3 Q16666-5

Post-translational modifications:

Phosphorylated on Ser and Thr¹

Isoform 3 seems to show a minor degree of complex carbohydrate addition¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005522.2

ENSEMBL proteins:

ENSP00000376078 ENSP00000295809 ENSP00000357113 ENSP00000342741 ENSP00000352740 ENSP00000357114

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFI16)
	Human Recombinant Proteins from Abnova (IFI16)

OriGene Purified Recombinant Human Protein: IFI16

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	7536752
GO:0005654	nucleoplasm	IDA	14654789
GO:0005730	nucleolus	IDA	14654789
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for IFI16:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for IFI16
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFI16), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFI16)
	Novus Biologicals Antibodies for IFI16

Assays for IFI16:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16666

ProtoNet protein and cluster: Q16666

2 Blocks protein families:

IPB004020 Pyrin domain

IPB004021 HIN-200/IF120x domain

UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666

Similarity: Belongs to the HIN-200 family

Similarity: Contains 1 DAPIN domain

Similarity: Contains 2 HIN-200 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFI16)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005531

Applied Biosystems Silencer® siRNAs for IFI16

Sigma-Aldrich siRNA for IFI16

Sigma-Aldrich shRNA Panels and shRNA for IFI16

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFI16
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005531
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005531
untagged cDNA clone in CMV expression vector: NM_005531

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005531

UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666

Function: May function as a transcriptional repressor. Could have a role in the regulation of

hematopoeitic differentiation through activation of unknown target genes. Controls cellular

proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and

the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells

Induction: Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. In

HL-60 cells, maximum induction by gamma-interferon occurs within 12 hours whereas, for

alpha-interferon, only 10-fold induction was observed after 36 hours. Induced in vitro by

dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3

Genatlas biochemistry entry for IFI16:

nuclear protein,constitutively expressed in lymphocytes,interferon alpha or gamma inducible in

myeloid cells (clone IFI-6-16)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003690	double-stranded DNA binding	IDA	7536752
GO:0005515	protein binding	IDA	14654789
GO:0016564	transcription repressor activity	IDA	9642285

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for IFI16

5/10 Interacting proteins for IFI16 (ENSP00000295809³ Q16666²) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275²	STRING (score=.709) MINT-1781599 MINT-1781673 MINT-1781653
TP53	ENSP00000269305³	STRING (score=.978)
BRCA1	ENSP00000350283³	STRING (score=.964)
IFNG	ENSP00000229135³	STRING (score=.864)
CYFIP2	ENSP00000366799³	STRING (score=.831)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0008283	cell proliferation	NAS	9766636
GO:0009615	response to virus	NAS	--
GO:0030099	myeloid cell differentiation	NAS	7536752

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFI16
2 Novoseek chemical compound relationships for IFI16 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mnda	97.90	15	7536752 (4), 11215814 (3), 10828447 (1), 18598717 (1) (see all 10)
p202	94.87	2	18598717 (1), 9642285 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFI16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFI16)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005531

Sigma-Aldrich siRNA for IFI16

Sigma-Aldrich shRNA Panels and shRNA for IFI16

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005531

REFSEQ mRNAs for IFI16 gene:

NM_005531.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005531

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005531
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005531
                                 untagged cDNA clone in CMV expression vector: NM_005531

Additional cDNA sequence:

AB208989.1 AF086545.1 AK094968.1 AK296228.1 AK307957.1 AY138863.1 BC017059.1 CR603557.1

CR620182.1 CR621058.1 M63838.1

18 DOTS entries:

DT.417806 DT.448189 DT.97859254 DT.100822067 DT.92443457 DT.100822075 DT.121449325 DT.100034821

DT.99982594 DT.121449318 DT.99950181 DT.121449368 DT.417808 DT.100720178 DT.100822071 DT.40248264

DT.40311625 DT.121449307

24/403 AceView cDNA sequences (see all 403 ):

BE349546 BC073133 BP346392 AA715151 NM_152501 AA588812 BI518461 CD252021

BM806453 AI431953 NM_198928 BE843017 AY185345 CA423715 BP352007 AW801462

BU629095 CA395220 BQ448467 AI676098 CA442332 BQ004288 BM971453 AA593188

highest scoring ESTs for IFI16:

M63838 AA115982 AA128052 AA169187 AA455666 AA485213 AA490996 AA558194 AA573959 AA574099

Unigene Cluster for IFI16:

Interferon, gamma-inducible protein 16

Hs.380250 [show with all ESTs]

Unigene Representative Sequence: NM_005531

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IFI16 (see all 12 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	^	12	^	13	^	14a	·	14b	·	14c	^
SP1:
SP2:																																													-
SP3:																																											-		-
SP4:
SP5:							-				-

ExUns:	15a	·	15b	·	15c	^	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IFI16

6 Ensembl transcripts including schematic representations:

ENST00000392247 ENST00000295809 ENST00000368131 ENST00000340979 ENST00000359709 ENST00000368132

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFI16 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFI16

¹ / ² / ³

7 probe-sets matching IFI16 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1456_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M63838	1.00	1.00	1.00	1
206332_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005531	0.60	1.00	0.82	1
208966_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF208043	0.60	1.00	0.82	1
208965_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BG256677	0.60	1.00	0.82	1
206332_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208966_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208965_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks IFI16 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACGACTGAC

SOURCE GeneReport for Unigene cluster: Hs.380250
Expression variation in blood from EXPOLDB for IFI16
UniProtKB/Swiss-Prot: IF16_HUMAN, Q16666
Tissue specificity: Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells.
Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is
down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and
breast (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFI16 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	IFI16¹	--	interferon, gamma-inducible protein 16	99.27(n) 98.35(a)	457424 XM_001170303.1 XP_001170303.1
cow (Bos taurus)	IFI16¹	--	interferon, gamma-inducible protein 16	65.5(n) 48.06(a)	506759 XM_863928.2 XP_869021.2
mouse (Mus musculus)	Ifi204⁵	1 (95.20 cM)	interferon activated gene 204	--	M31419

About this table Species with no ortholog for IFI16

ENSEMBL Gene Tree for IFI16

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFI16 gene

AIM2² PYHIN1² MNDA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/418 NCBI SNPs in IFI16 are shown (see all 418 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1417806^1,2	A,C,F,H,O	157245815(-)	`TGTCTG/TCTATG`	1	--	ng5¹		21	NS EA NA MN EU WA	2900
	rs856059^1,2	A,C,F,H	157244336(-)	`TGTGGT/CATATG`	1	--	ng5¹		8	EA NA EU WA	636
--	rs866484^1,2	A,C,F,H	157253101(-)	`AAGAAG/CTGTTG`	1	T/S	mis¹		15	EA NA MN EU WA	1236
	rs1057028^1,2	A,C,F,H	157269013(+)	`TTCCAA/TATCCT`	1	Y/N	mis¹ ese³		9	MN EU EA WA	1022
	rs1057027^1,2	A,C,F,H	157269001(+)	`AACAGA/CGTCAG`	1	R/S	mis¹		9	EU EA WA MN	1020
	rs1417805^1,2	A,C,F,H	157246082(-)	`CATAAA/CTGTAT`	1	--	ng5¹		3	EA WA	260
	rs6940^1,2	A,C,F,H	157291292(+)	`TGGAAA/TCTTCA`	1	T/S	mis¹		13	MN EU EA WA NA	1384
	rs855864^1,2	C,F,H	157292031(+)	`ATATTT/CCCTGT`	1	--	ng3¹		7	EU EA WA NA	430
--	rs1465175^1,2	A,C,F	157245546(+)	`TCAAGG/TCTTCG`	1	--	ng5¹		6	NS	214
	rs9887904^1,2	C,F,H	157245220(+)	`GGTTTC/AAAATC`	1	--	ng5¹		11	EU EA WA NA	982

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HapMap Linkage Disequilibrium images for IFI16 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147586

4 Novoseek disease relationships for IFI16 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	37.67	1	17911419 (1)
melanoma	25.51	2	9642285 (1), 14757431 (1)
cancer	8.01	1	17981573 (1)
tumors	0.00	10	17569615 (4), 18231640 (1), 19338980 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/56 PubMed articles for IFI16 gene (see all 56 ):

Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. (PubMed id 7959953)^{1, 2, 3, 4} Trapani J.A....Browne K.A. (1994)
A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. (PubMed id 1526658)^{1, 2, 3, 4} Trapani J.A.... Dupont B. (1992)
IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. (PubMed id 7536752)^{1, 3, 4} Dawson M.J. and Trapani J.A. (1995)
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. (PubMed id 12894224)^{1, 3, 4} Xin H.... Choubey D. (2003)
The human interferon-inducible protein, IFI 16, is a repressor of transcription. (PubMed id 9642285)^{1, 3, 4} Johnstone R.W.... Trapani J.A. (1998)
Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. (PubMed id 9718316)^{1, 3, 4} Johnstone R.W.... Trapani J.A. (1998)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3428	HGNC: 5395	AceView: IFI16andIFIX	Ensembl:ENSG00000163565	euGenes: HUgn3428
ECgene: IFI16	H-InvDB: IFI16

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFI16
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFI16:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFI16-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFI16		Antibodies for IFI16
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFI16		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for IFI16

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IFI16 Gene at Home site.
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IFI16 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for IFI16

Summaries
for IFI16

Genomic Location
for IFI16

Proteins
for IFI16

Protein Domains/
Families
for IFI16

Gene Function
for IFI16

Pathways & Interactions
for IFI16

Drugs & Compounds
for IFI16

Transcripts
for IFI16

Expression
for IFI16

Orthologs
for IFI16

Paralogs
for IFI16

SNPs/Variants
for IFI16

Disorders & Mutations
for IFI16

Medical News
for IFI16

Publications
for IFI16

Search for IFI16

Genome Databases showing IFI16

Other Databases showing IFI16

Specialized Databases showing IFI16

Licensable Technologies
for IFI16

Services
for IFI16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFI16 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor IFI16

Summariesfor IFI16

Genomic Locationfor IFI16

Proteinsfor IFI16

Protein Domains/Familiesfor IFI16

Gene Functionfor IFI16

Pathways & Interactionsfor IFI16

Drugs & Compoundsfor IFI16

Transcriptsfor IFI16

Expression for IFI16

Orthologsfor IFI16

Paralogsfor IFI16

SNPs/Variantsfor IFI16

Disorders & Mutationsfor IFI16

Medical Newsfor IFI16

Publicationsfor IFI16

Search for IFI16

Genome Databases showing IFI16

Other Databases showing IFI16

Specialized Databases showing IFI16

Licensable Technologiesfor IFI16

Servicesfor IFI16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFI16

Summaries
for IFI16

Genomic Location
for IFI16

Proteins
for IFI16

Protein Domains/
Families
for IFI16

Gene Function
for IFI16

Pathways & Interactions
for IFI16

Drugs & Compounds
for IFI16

Transcripts
for IFI16

Expression
for IFI16

Orthologs
for IFI16

Paralogs
for IFI16

SNPs/Variants
for IFI16

Disorders & Mutations
for IFI16

Medical News
for IFI16

Publications
for IFI16

Licensable Technologies
for IFI16

Services
for IFI16