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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFFO2 Gene

protein-coding GIFtS: 35
GCID: GC01M019230

intermediate filament family orphan 2

Search for IFFO2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Intermediate Filament Family Orphan 2¹ ²

External Ids:	HGNC: 27006¹	Entrez Gene: 126917²	Ensembl: ENSG00000169991⁷	UniProtKB: Q5TF58³

Export aliases for IFFO2 gene to outside databases

Previous GC identifers: GC01M019106 GC01M017474

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFFO2 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB Nkx2-5 C/EBPalpha JunD FOXJ2 c-Jun
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFFO2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

IFFO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFFO2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M019230: view genomic region (about GC identifiers)

Start:	19,230,774 bp from pter	End:	19,283,180 bp from pter
Size:	52,407 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFFO2_HUMAN, Q5TF58 (See protein sequence)

Recommended Name: Intermediate filament family orphan 2

Size: 517 amino acids; 57328 Da

Sequence caution: Sequence=CAI23419.1; Type=Erroneous gene model prediction;

Secondary accessions: Q9H7K0

Explore the universe of human proteins at neXtProt for IFFO2: NX_Q5TF58

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TF58

IFFO2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001129737.1

ENSEMBL proteins:

ENSP00000387941 ENSP00000347820 ENSP00000394655

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFFO2 for domains About GeneDecksing

2 InterPro domains/families:

IPR026665 Iffo1/2

IPR016044 F

Graphical View of Domain Structure for InterPro Entry Q5TF58

ProtoNet protein and cluster: Q5TF58

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFFO2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IFFO2 (ENSP00000387941⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for IFFO2
Search CenterWatch for drugs/clinical trials and news about IFFO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IFFO2 gene:

NM_001136265.1

Unigene Cluster for IFFO2:

Intermediate filament family orphan 2

Hs.466625 [show with all ESTs]

Unigene Representative Sequence: NM_001136265

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455833(uc001bbd.2) ENST00000355609 ENST00000416166

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Additional cDNA sequence:

AK024480.1 BC063709.1

5 DOTS entries:

DT.451693 DT.100773053 DT.100773043 DT.75102462 DT.91883379

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFFO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

IFFO2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IFFO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFFO2

SOURCE GeneReport for Unigene cluster: Hs.466625

SABiosciences Custom PCR Arrays for IFFO2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFFO2 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IFFO2¹	intermediate filament family orphan 2	79.25(n) 86.73(a)		419468 XM_003642530.1 XP_003642578.1
lizard (Anolis carolinensis)	Reptilia	IFFO2⁶	--	89(a)	1 → many	GL344244.1(31177-60810)
zebrafish (Danio rerio)	Actinopterygii	LOC100150502¹	intermediate filament family orphan 1-like	69.11(n) 70.64(a)		100150502 XM_001919891.2 XP_001919926.2

ENSEMBL Gene Tree for IFFO2 (if available)
TreeFam Gene Tree for IFFO2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFFO2 gene

ENSG00000255275² IFFO1²

4 SIMAP similar genes for IFFO2 using alignment to 3 protein entries: IFFO2_HUMAN (see all proteins):

DKFZp586I2223 DKFZp686D0339 IFFO1 DES

IFFO2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77038531^1,2	F	--	19231305(+)	`TCCCCC/TCAGGG`	1	--	ut3¹		1		NA	120
rs139702339^1,2		--	19231436(+)	`GACCCA/GCAAAG`	1	--	ut3¹		0	--	--	--	--
rs192952405^1,2		--	19231462(+)	`AAGTCA/GTGTGC`	1	--	ut3¹		0	--	--	--	--
rs2295228^1,2	C,F	--	19231477(+)	`ACTGTC/TACCCA`	1	--	ut3¹ ese³		1		EA	1496
rs183787117^1,2		--	19231609(+)	`AATGCA/GCCTTG`	1	--	ut3¹		0	--	--	--	--
rs187921725^1,2		--	19231625(+)	`TCCCCC/TACCCA`	1	--	ut3¹		0	--	--	--	--
rs28478026^1,2	C	--	19231800(+)	`AGGCCG/AGGGGA`	1	--	ut3¹ ese³		2		NA	122
rs191851457^1,2		--	19231904(+)	`AAAACC/GCTTCC`	1	--	ut3¹		0	--	--	--	--
rs183616429^1,2		--	19231998(+)	`ACCCCC/TTCTCC`	1	--	ut3¹		0	--	--	--	--
rs76802533^1,2		--	19232017(+)	`CAAGCG/TTAAGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFFO2 (19230774 - 19283180 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFFO2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFFO2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IFFO2)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2, 3} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 126917	HGNC: 27006	Ensembl:ENSG00000169991	euGenes: HUgn126917	ECgene: IFFO2
H-InvDB: IFFO2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFFO2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFFO2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFFO2 gene:
Search GeneIP for patents involving IFFO2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFFO2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for IFFO2
	Browse SwitchGear Promoter luciferase reporter plasmids for IFFO2

Search ThermoFisher Antibodies for IFFO2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IFFO2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IFFO2

Sirion Biotech Customized:

	stable knockdown cell line services for IFFO2
	inducible knockdown cell line services for IFFO2
	design and validation of potent shRNA sequences against IFFO2
	adenovirus for potent knockdown of IFFO2
	adenovirus for overexpression of IFFO2
	stable overexpressing cell line services for IFFO2
	inducible overexpressing cell line services for IFFO2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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IFFO2 Gene

intermediate filament family orphan 2

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Export list of displayed genes

IFFO2 Gene

intermediate filament family orphan 2

Aliasesfor IFFO2 gene

Summariesfor IFFO2 gene

Genomic Viewsfor IFFO2 gene

Proteinsfor IFFO2 gene

Protein Domains /Familiesfor IFFO2 gene

Functionfor IFFO2 gene

Pathways & Interactionsfor IFFO2 gene

Drugs & Compoundsfor IFFO2 gene

Transcriptsfor IFFO2 gene

Expression for IFFO2 gene

Orthologsfor IFFO2 gene

Paralogsfor IFFO2 gene

Genomic Variantsfor IFFO2 gene

Disorders / Diseasesfor IFFO2 gene

Publicationsfor IFFO2 gene

External Searches for IFFO2 gene

Genome Databases showing IFFO2 gene

Other Databases showing IFFO2 gene

Specialized Databases showing IFFO2 gene

Intellectual Propertyfor IFFO2 gene

Productsfor IFFO2 gene

View Random Gene

Aliases
for IFFO2 gene

Summaries
for IFFO2 gene

Genomic Views
for IFFO2 gene

Proteins
for IFFO2 gene

Protein Domains /
Families
for IFFO2 gene

Function
for IFFO2 gene

Pathways & Interactions
for IFFO2 gene

Drugs & Compounds
for IFFO2 gene

Transcripts
for IFFO2 gene

Expression
for IFFO2 gene

Orthologs
for IFFO2 gene

Paralogs
for IFFO2 gene

Genomic Variants
for IFFO2 gene

Disorders / Diseases
for IFFO2 gene

Publications
for IFFO2 gene

Intellectual Property
for IFFO2 gene

Products
for IFFO2 gene