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Aliases for IFFO2 Gene

Aliases for IFFO2 Gene

  • Intermediate Filament Family Orphan 2 2 3

External Ids for IFFO2 Gene

Previous GeneCards Identifiers for IFFO2 Gene

  • GC01M019106
  • GC01M019230
  • GC01M017474

Summaries for IFFO2 Gene

GeneCards Summary for IFFO2 Gene

IFFO2 (Intermediate Filament Family Orphan 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFFO2 Gene

Genomics for IFFO2 Gene

Regulatory Elements for IFFO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IFFO2 Gene

18,904,280 bp from pter
18,956,686 bp from pter
52,407 bases
Minus strand

Genomic View for IFFO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFFO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO2 Gene

Proteins for IFFO2 Gene

  • Protein details for IFFO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intermediate filament family orphan 2
    Protein Accession:
    Secondary Accessions:
    • Q9H7K0

    Protein attributes for IFFO2 Gene

    517 amino acids
    Molecular mass:
    57328 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI23419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IFFO2 Gene

Proteomics data for IFFO2 Gene at MOPED

Post-translational modifications for IFFO2 Gene

  • Ubiquitination at Lys303
  • Modification sites at PhosphoSitePlus

Other Protein References for IFFO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFFO2 Gene

Domains for IFFO2 Gene

Gene Families for IFFO2 Gene

  • IFFO :Intermediate filament family orphans

Protein Domains for IFFO2 Gene


Suggested Antigen Peptide Sequences for IFFO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IFFO2: view

No data available for UniProtKB/Swiss-Prot for IFFO2 Gene

Function for IFFO2 Gene

Gene Ontology (GO) - Molecular Function for IFFO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with IFFO2: view

Animal Model Products

CRISPR Products

miRNA for IFFO2 Gene

miRTarBase miRNAs that target IFFO2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFFO2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFFO2 Gene

Localization for IFFO2 Gene

Subcellular locations from

Jensen Localization Image for IFFO2 Gene COMPARTMENTS Subcellular localization image for IFFO2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFFO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFFO2 Gene

Pathways for IFFO2 Gene

SuperPathways for IFFO2 Gene

No Data Available

Interacting Proteins for IFFO2 Gene

Gene Ontology (GO) - Biological Process for IFFO2 Gene


No data available for Pathways by source for IFFO2 Gene

Transcripts for IFFO2 Gene

mRNA/cDNA for IFFO2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFFO2 Gene

Intermediate filament family orphan 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFFO2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO2 Gene

No ASD Table

Relevant External Links for IFFO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFFO2 Gene

mRNA expression in normal human tissues for IFFO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFFO2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (9.5), Skin - Sun Exposed (Lower leg) (8.9), and Esophagus - Mucosa (4.0).

Protein differential expression in normal tissues for IFFO2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFFO2 Gene

SOURCE GeneReport for Unigene cluster for IFFO2 Gene Hs.466625

genes like me logo Genes that share expressions with IFFO2: view

Expression partners for IFFO2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IFFO2 Gene

Orthologs for IFFO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFFO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IFFO2 35
  • 95.29 (n)
  • 98.65 (a)
(Mus musculus)
Mammalia Iffo2 35
  • 90.17 (n)
  • 92.77 (a)
Iffo2 16
Iffo2 36
  • 92 (a)
(Pan troglodytes)
Mammalia IFFO2 35
  • 98.64 (n)
  • 98.26 (a)
IFFO2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Iffo2 35
  • 93.03 (n)
  • 98.25 (a)
(Bos Taurus)
Mammalia -- 36
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
(Gallus gallus)
Aves IFFO2 35
  • 79.5 (n)
  • 87.16 (a)
-- 36
  • 85 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo2 35
  • 78.72 (n)
  • 82.43 (a)
(Danio rerio)
Actinopterygii LOC100150502 35
  • 69.08 (n)
  • 70.4 (a)
CABZ01030889.1 36
  • 65 (a)
iffo2a 36
  • 64 (a)
Species with no ortholog for IFFO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO2 Gene

Gene Tree for IFFO2 (if available)
Gene Tree for IFFO2 (if available)

Paralogs for IFFO2 Gene

Paralogs for IFFO2 Gene

Selected SIMAP similar genes for IFFO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IFFO2: view

Variants for IFFO2 Gene

Sequence variations from dbSNP and Humsavar for IFFO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs992660 -- 18,934,747(+) ACAAC(A/G)GGATG intron-variant
rs992661 -- 18,934,914(+) ACCTT(C/T)GTACC intron-variant
rs1406842 -- 18,956,916(-) GGCAG(C/G)ACCAG upstream-variant-2KB
rs1886768 -- 18,956,487(-) CCGTC(G/T)CTGCG upstream-variant-2KB
rs2024724 -- 18,910,613(+) CCTCC(A/G)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFFO2 Gene

Variant ID Type Subtype PubMed ID
nsv834347 CNV Gain 17160897
esv2744796 CNV Deletion 23290073
nsv512722 CNV Insertion 21212237

Relevant External Links for IFFO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFFO2 Gene

Disorders for IFFO2 Gene

Relevant External Links for IFFO2

Genetic Association Database (GAD)

No disorders were found for IFFO2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IFFO2 Gene

Publications for IFFO2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for IFFO2 Gene

Sources for IFFO2 Gene

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