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Aliases for IFFO1 Gene

Aliases for IFFO1 Gene

  • Intermediate Filament Family Orphan 1 2 3 5
  • IFFO 3 4
  • Intermediate Filament Family Orphan 2
  • Intermediate Filament-Like MGC:2625 3
  • Tumor Antigen HOM-TES-103 4
  • HOM-TES-103 3

External Ids for IFFO1 Gene

Previous HGNC Symbols for IFFO1 Gene

  • IFFO

Previous GeneCards Identifiers for IFFO1 Gene

  • GC12M006521
  • GC12M006648

Summaries for IFFO1 Gene

Entrez Gene Summary for IFFO1 Gene

  • This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IFFO1 Gene

IFFO1 (Intermediate Filament Family Orphan 1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFFO1 Gene

Genomics for IFFO1 Gene

Regulatory Elements for IFFO1 Gene

Enhancers for IFFO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G006602 1.7 FANTOM5 ENCODE dbSUPER 12.2 -49.6 -49645 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000219410 ENSG00000247853 NOP2 ACRBP ZNF384 LPAR5 SCARNA11 IFFO1 ING4 C12orf57
GH12G006546 1.8 FANTOM5 ENCODE dbSUPER 10.9 +4.2 4168 10.3 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000219410 ENSG00000247853 NCAPD2 TAPBPL NOP2 SCARNA12 VAMP1 SPSB2 SCARNA11 CHD4
GH12G006344 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +209.5 209474 3.6 PKNOX1 ATF1 CREB3L1 ARNT E2F7 SIN3A BRCA1 TCF12 GATA2 FOS CHD4 LTBR SCNN1A VAMP1 ENSG00000247853 SCARNA11 ACRBP IFFO1 NOP2 ENSG00000219410
GH12G006442 1.6 Ensembl ENCODE dbSUPER 10.6 +110.6 110588 6.0 HDGF PKNOX1 AGO1 WRNIP1 SIN3A ARID4B YBX1 YY1 ZNF143 ZNF548 CD27-AS1 NOP2 TAPBPL ENSG00000219410 ENSG00000247853 ENSG00000255966 GAPDH VAMP1 TNFRSF1A NCAPD2
GH12G006321 1.5 Ensembl ENCODE dbSUPER 10.3 +231.0 230990 6.5 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF48 ZNF121 GLIS2 GATA2 FOS VAMP1 LTBR SCNN1A CD27-AS1 TAPBPL CD27 GAPDH ENSG00000255966 IFFO1 CD9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFFO1 on UCSC Golden Path with GeneCards custom track

Promoters for IFFO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for IFFO1 Gene

6,538,375 bp from pter
6,556,083 bp from pter
17,709 bases
Minus strand

Genomic View for IFFO1 Gene

Genes around IFFO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFFO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFFO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO1 Gene

Proteins for IFFO1 Gene

  • Protein details for IFFO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intermediate filament family orphan 1
    Protein Accession:
    Secondary Accessions:
    • Q24JT6
    • Q7L5J9
    • Q7Z5X4
    • Q9BQ46

    Protein attributes for IFFO1 Gene

    559 amino acids
    Molecular mass:
    61979 Da
    Quaternary structure:
    No Data Available
    • Sequence=AF124432; Type=Frameshift; Positions=119, 226, 384; Evidence={ECO:0000305}; Sequence=AF124432; Type=Frameshift; Positions=121, 227, 385; Evidence={ECO:0000305};

    Alternative splice isoforms for IFFO1 Gene

neXtProt entry for IFFO1 Gene

Post-translational modifications for IFFO1 Gene

  • Ubiquitination at posLast=7878, posLast=103103, and isoforms=3, 4, 5, 7113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IFFO1 Gene

Domains & Families for IFFO1 Gene

Gene Families for IFFO1 Gene

Protein Domains for IFFO1 Gene


Suggested Antigen Peptide Sequences for IFFO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO1: view

Function for IFFO1 Gene

Gene Ontology (GO) - Molecular Function for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with IFFO1: view

Phenotypes for IFFO1 Gene

genes like me logo Genes that share phenotypes with IFFO1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFFO1 Gene

Localization for IFFO1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFFO1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFFO1 Gene

Pathways & Interactions for IFFO1 Gene

SuperPathways for IFFO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFFO1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IFFO1 Gene

Drugs & Compounds for IFFO1 Gene

No Compound Related Data Available

Transcripts for IFFO1 Gene

Unigene Clusters for IFFO1 Gene

Intermediate filament family orphan 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP4: - - -
SP5: - -

Relevant External Links for IFFO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFFO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFFO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFFO1 Gene

This gene is overexpressed in Heart (49.2), Milk (9.1), and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFFO1 Gene

Protein tissue co-expression partners for IFFO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFFO1 Gene:


SOURCE GeneReport for Unigene cluster for IFFO1 Gene:


mRNA Expression by UniProt/SwissProt for IFFO1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for IFFO1 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with IFFO1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFFO1 Gene

Orthologs for IFFO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IFFO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFFO1 34 35
  • 99.77 (n)
(Bos Taurus)
Mammalia IFFO1 35
  • 94 (a)
(Canis familiaris)
Mammalia IFFO1 34 35
  • 92.96 (n)
(Mus musculus)
Mammalia Iffo1 34 16 35
  • 89.32 (n)
(Rattus norvegicus)
Mammalia Iffo1 34
  • 88.66 (n)
(Monodelphis domestica)
Mammalia IFFO1 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia IFFO1 35
  • 85 (a)
(Gallus gallus)
Aves IFFO1 35
  • 81 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
-- 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo1 34
  • 70.57 (n)
Str.2744 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22282 34
(Danio rerio)
Actinopterygii LOC563794 34
  • 64.18 (n)
iffo1a 35
  • 50 (a)
iffo1b 35
  • 50 (a)
sbcb164 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2490 34
(Hordeum vulgare)
Liliopsida Hv.5144 34
(Oryza sativa)
Liliopsida Os.16852 34
(Zea mays)
Liliopsida Zm.731 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1551 34
Species where no ortholog for IFFO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO1 Gene

Gene Tree for IFFO1 (if available)
Gene Tree for IFFO1 (if available)

Paralogs for IFFO1 Gene

Paralogs for IFFO1 Gene

(5) SIMAP similar genes for IFFO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFFO1: view

Variants for IFFO1 Gene

Sequence variations from dbSNP and Humsavar for IFFO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000043749 -- 6,545,838(+) GTATG(A/G)CAGTG intron-variant
rs1000108220 -- 6,543,285(+) CCCAG(A/G)CCACG intron-variant
rs1000335740 -- 6,553,504(+) CATAA(C/G)ATGGA intron-variant, upstream-variant-2KB
rs1000398238 -- 6,556,824(+) CCCTT(-/A)AAAGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000453804 -- 6,553,332(+) AGTTT(A/T)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFFO1 Gene

Variant ID Type Subtype PubMed ID
esv2759876 CNV gain 17122850
esv3628408 CNV gain 21293372

Variation tolerance for IFFO1 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFFO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFFO1 Gene

Disorders for IFFO1 Gene

Relevant External Links for IFFO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFFO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFFO1 Gene

Publications for IFFO1 Gene

  1. Intermediate filament proteins. (PMID: 8771189) Quinlan R. … Lane B. (Protein Profile 1995) 2 3 64
  2. Molecular and cellular biology of intermediate filaments. (PMID: 3052284) Steinert P.M. … Roop D.R. (Annu. Rev. Biochem. 1988) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for IFFO1 Gene

Sources for IFFO1 Gene

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