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Aliases for IFFO1 Gene

Aliases for IFFO1 Gene

  • Intermediate Filament Family Orphan 1 2 3
  • IFFO 3 4
  • Intermediate Filament Family Orphan 2
  • Intermediate Filament-Like MGC:2625 3
  • Tumor Antigen HOM-TES-103 4
  • HOM-TES-103 3

External Ids for IFFO1 Gene

Previous HGNC Symbols for IFFO1 Gene

  • IFFO

Previous GeneCards Identifiers for IFFO1 Gene

  • GC12M006521
  • GC12M006648

Summaries for IFFO1 Gene

Entrez Gene Summary for IFFO1 Gene

  • This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IFFO1 Gene

IFFO1 (Intermediate Filament Family Orphan 1) is a Protein Coding gene. An important paralog of this gene is IFFO2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFFO1 Gene

Genomics for IFFO1 Gene

Regulatory Elements for IFFO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IFFO1 Gene

Start:
6,538,375 bp from pter
End:
6,556,083 bp from pter
Size:
17,709 bases
Orientation:
Minus strand

Genomic View for IFFO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFFO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO1 Gene

Proteins for IFFO1 Gene

  • Protein details for IFFO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0D2I5-IFFO1_HUMAN
    Recommended name:
    Intermediate filament family orphan 1
    Protein Accession:
    Q0D2I5
    Secondary Accessions:
    • Q24JT6
    • Q7L5J9
    • Q7Z5X4
    • Q9BQ46

    Protein attributes for IFFO1 Gene

    Size:
    559 amino acids
    Molecular mass:
    61979 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AF124432; Type=Frameshift; Positions=119, 226, 384; Evidence={ECO:0000305}; Sequence=AF124432; Type=Frameshift; Positions=121, 227, 385; Evidence={ECO:0000305};

    Alternative splice isoforms for IFFO1 Gene

neXtProt entry for IFFO1 Gene

Proteomics data for IFFO1 Gene at MOPED

Post-translational modifications for IFFO1 Gene

  • Ubiquitination at Lys78, Lys103, Lys113, and Lys339
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IFFO1 Gene

Domains for IFFO1 Gene

Gene Families for IFFO1 Gene

HGNC:
  • IFFO :Intermediate filament family orphans

Protein Domains for IFFO1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFFO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q0D2I5

UniProtKB/Swiss-Prot:

IFFO1_HUMAN :
  • Q0D2I5
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO1: view

Function for IFFO1 Gene

Gene Ontology (GO) - Molecular Function for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
genes like me logo Genes that share ontologies with IFFO1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFFO1 Gene

Localization for IFFO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFFO1 Gene COMPARTMENTS Subcellular localization image for IFFO1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFFO1 Gene

Pathways for IFFO1 Gene

SuperPathways for IFFO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFFO1 Gene

None

No data available for Pathways by source for IFFO1 Gene

Transcripts for IFFO1 Gene

Unigene Clusters for IFFO1 Gene

Intermediate filament family orphan 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFFO1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IFFO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3:
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for IFFO1 Gene

GeneLoc Exon Structure for
IFFO1
ECgene alternative splicing isoforms for
IFFO1

Expression for IFFO1 Gene

mRNA expression in normal human tissues for IFFO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFFO1 Gene

SOURCE GeneReport for Unigene cluster for IFFO1 Gene Hs.15243

mRNA Expression by UniProt/SwissProt for IFFO1 Gene

Q0D2I5-IFFO1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with IFFO1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IFFO1 Gene

Orthologs for IFFO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IFFO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFFO1 35
  • 99.77 (n)
  • 99.65 (a)
IFFO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFFO1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFFO1 35
  • 92.96 (n)
  • 96.17 (a)
IFFO1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iffo1 35
  • 89.32 (n)
  • 94.66 (a)
Iffo1 16
Iffo1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFFO1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFFO1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iffo1 35
  • 88.66 (n)
  • 94.42 (a)
chicken
(Gallus gallus)
Aves IFFO1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.22282 35
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo1 35
  • 70.57 (n)
  • 74.19 (a)
Str.2744 35
zebrafish
(Danio rerio)
Actinopterygii iffo1a 36
  • 50 (a)
OneToMany
iffo1b 36
  • 50 (a)
OneToMany
LOC563794 35
  • 64.18 (n)
  • 68.23 (a)
sbcb164 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2490 35
barley
(Hordeum vulgare)
Liliopsida Hv.5144 35
corn
(Zea mays)
Liliopsida Zm.731 35
rice
(Oryza sativa)
Liliopsida Os.16852 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1551 35
Species with no ortholog for IFFO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO1 Gene

ENSEMBL:
Gene Tree for IFFO1 (if available)
TreeFam:
Gene Tree for IFFO1 (if available)

Paralogs for IFFO1 Gene

Paralogs for IFFO1 Gene

Selected SIMAP similar genes for IFFO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFFO1: view

Variants for IFFO1 Gene

Sequence variations from dbSNP and Humsavar for IFFO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs740852 -- 6,541,160(-) TACAC(C/T)GCAAC intron-variant, downstream-variant-500B
rs758740 -- 6,539,938(+) GAGCA(C/T)GTGGA utr-variant-3-prime, nc-transcript-variant
rs1047792 -- 6,539,933(-) GTGCT(A/C)ACGCT utr-variant-3-prime, nc-transcript-variant
rs1063206 -- 6,539,614(-) GGTTC(A/C)CAATG utr-variant-3-prime, nc-transcript-variant
rs2240872 -- 6,539,103(+) CTCAG(G/T)TGCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFFO1 Gene

Variant ID Type Subtype PubMed ID
dgv453e1 CNV Complex 17122850
nsv898634 CNV Loss 21882294

Relevant External Links for IFFO1 Gene

HapMap Linkage Disequilibrium report
IFFO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFFO1 Gene

Disorders for IFFO1 Gene

No disorders were found for IFFO1 Gene.

No data available for UniProtKB/Swiss-Prot for IFFO1 Gene

Publications for IFFO1 Gene

  1. Molecular and cellular biology of intermediate filaments. (PMID: 3052284) Steinert P.M. … Roop D.R. (Annu. Rev. Biochem. 1988) 2 3
  2. Intermediate filament proteins. (PMID: 8771189) Quinlan R. … Lane B. (Protein Profile 1995) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for IFFO1 Gene

Sources for IFFO1 Gene

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