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Aliases for IER5L Gene

Aliases for IER5L Gene

  • Immediate Early Response 5-Like 2 3
  • Immediate Early Response Gene 5-Like Protein 3
  • BA247A12.2 3

External Ids for IER5L Gene

Previous GeneCards Identifiers for IER5L Gene

  • GC09M129018
  • GC09M130977
  • GC09M131937
  • GC09M101545

Summaries for IER5L Gene

GeneCards Summary for IER5L Gene

IER5L (Immediate Early Response 5-Like) is a Protein Coding gene. An important paralog of this gene is IER5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5L Gene

Genomics for IER5L Gene

Regulatory Elements for IER5L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IER5L Gene

129,175,552 bp from pter
129,178,262 bp from pter
2,711 bases
Minus strand

Genomic View for IER5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IER5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5L Gene

Proteins for IER5L Gene

  • Protein details for IER5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immediate early response gene 5-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6P3E2

    Protein attributes for IER5L Gene

    404 amino acids
    Molecular mass:
    42109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IER5L Gene


neXtProt entry for IER5L Gene

Proteomics data for IER5L Gene at MOPED

Post-translational modifications for IER5L Gene

No Post-translational modifications

Other Protein References for IER5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5L Gene

Domains for IER5L Gene

Protein Domains for IER5L Gene


Suggested Antigen Peptide Sequences for IER5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IER family.
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5L: view

No data available for Gene Families for IER5L Gene

Function for IER5L Gene

Phenotypes for IER5L Gene

GenomeRNAi human phenotypes for IER5L:
genes like me logo Genes that share phenotypes with IER5L: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IER5L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IER5L Gene

Localization for IER5L Gene

Subcellular locations from

Jensen Localization Image for IER5L Gene COMPARTMENTS Subcellular localization image for IER5L gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5L Gene

Pathways for IER5L Gene

SuperPathways for IER5L Gene

No Data Available

Interacting Proteins for IER5L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361569 for IER5L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IER5L Gene


No data available for Pathways by source for IER5L Gene

Transcripts for IER5L Gene

mRNA/cDNA for IER5L Gene

(123) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5L Gene

Immediate early response 5-like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IER5L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER5L Gene

No ASD Table

Relevant External Links for IER5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IER5L Gene

mRNA expression in normal human tissues for IER5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for IER5L Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IER5L Gene

SOURCE GeneReport for Unigene cluster for IER5L Gene Hs.529857

genes like me logo Genes that share expressions with IER5L: view

Expression partners for IER5L Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IER5L Gene

Orthologs for IER5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IER5L 35
  • 92.93 (n)
  • 90.4 (a)
IER5L 36
  • 90 (a)
(Canis familiaris)
Mammalia IER5L 35
  • 93.23 (n)
  • 90.98 (a)
IER5L 36
  • 91 (a)
(Mus musculus)
Mammalia Ier5l 35
  • 92.56 (n)
  • 92.73 (a)
Ier5l 16
Ier5l 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Ier5l 35
  • 92.58 (n)
  • 92 (a)
(Monodelphis domestica)
Mammalia IER5L 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ier5l 35
  • 74.83 (n)
  • 76 (a)
MGC75980 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33398 35
(Danio rerio)
Actinopterygii ier5l 35
  • 68.46 (n)
  • 74.51 (a)
wufe50b07 35
ier5l 36
  • 52 (a)
Species with no ortholog for IER5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5L Gene

Gene Tree for IER5L (if available)
Gene Tree for IER5L (if available)

Paralogs for IER5L Gene

Paralogs for IER5L Gene

genes like me logo Genes that share paralogs with IER5L: view

Variants for IER5L Gene

Sequence variations from dbSNP and Humsavar for IER5L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs449770 -- 129,177,870(-) cagca(C/G)cagca missense, reference
rs1075650 -- 129,176,634(-) CAGAG(A/G)GAAAA utr-variant-3-prime
rs1107185 -- 129,178,152(+) gcAGG(C/G)GTAAC utr-variant-5-prime
rs1329588 -- 129,178,359(-) CTGCG(A/C)CTGTC upstream-variant-2KB
rs2480445 -- 129,179,288(-) CGTCT(C/G)GAGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IER5L Gene

Variant ID Type Subtype PubMed ID
nsv818725 CNV Gain 17921354
nsv893909 CNV Loss 21882294
nsv825108 CNV Gain 20364138
nsv825110 CNV Gain 20364138
nsv825111 CNV Gain 20364138
esv2675916 CNV Deletion 23128226
nsv466578 CNV Loss 19166990

Relevant External Links for IER5L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5L Gene

Disorders for IER5L Gene

No disorders were found for IER5L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IER5L Gene

Publications for IER5L Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for IER5L Gene

Sources for IER5L Gene

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