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IER5L Gene

protein-coding   GIFtS: 40

GC09M130977
immediate early response 5-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC70833 2
OTTHUMP00000022330 2
bA247A12.2 1, 2
Descriptions
immediate early response 5-like 2
External Ids
HGNC: 236791
Entrez Gene: 3897922
UniProtKB: Q5T9533
Ensembl: ENSG000001884837
Search outside databases for aliases for IER5L gene

Previous GC identifer: GC09M129018

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IER5L gene  

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC chromosome: 9

IER5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130977:     (about GC identifiers)

Start:
130,977,652 bp from pter
End:
130,980,362 bp from pter
Size:
2,711 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953 (See protein sequence)
Recommended Name: Immediate early response gene 5-like protein  
Size: 404 amino acids; 42109 Da
Secondary accessions: Q6P3E2
Alternative splicing: 2 isoforms:  Q5T953-1   Q5T953-2   

REFSEQ proteins: NP_982258.2  

ENSEMBL proteins: 
ENSP00000361569 ENSP00000344405 


Human Recombinant Proteins 
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for IER5L: 
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Sigma-Aldrich Antibodies for IER5L
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for IER5L

Assays for IER5L: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR008653 IER


   GeneDecks  IER5L for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q5T953

ProtoNet protein and cluster: Q5T953

UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953
Similarity: Belongs to the IER family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IER5L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_203434

              Applied Biosystems Silencer® siRNAs for IER5L

              Sigma-Aldrich siRNA for IER5L  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_203434
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_203434
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_203434 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_203434

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IER5L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IER5L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_203434

              Sigma-Aldrich siRNA for IER5L  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_203434  

REFSEQ mRNAs for IER5L gene: 

NM_203434.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_203434  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_203434
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_203434
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_203434 

Additional cDNA sequence: 

AK123797.1 AK308944.1 

5 DOTS entries:

DT.437639  DT.307819  DT.101972043  DT.100686737  DT.100820935 

24/123 AceView cDNA sequences (see all 123 ):

BM781986 AI693592 BM851449 CF127075 BM761092 CR610382 BM850200 BE550112 
BM847674 BM795407 BM856770 BM818550 AW104728 BQ102322 BM848377 BQ071193 
BM768187 AI219791 BQ086229 BQ574938 BM767794 BM845162 AI912541 CK822924 

highest scoring ESTs for IER5L:

AI916544 AA864817 AI362655 AI375903 AI393058 AI571569 AI655287 AI671951 AI739550 AI825373 

Unigene Clusters for IER5L:

Immediate early response 5-like
Hs.529857  [show with all ESTs], Hs.640233  [show with all ESTs]
Unigene Representative Sequences: NM_203434, AK123797


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000372491  ENST00000339671  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IER5L expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IER5L

1 / 2 / 3

6 probe-sets matching IER5L gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
90603_at2, 3 U95-E 1 1.00 1.00 0.95 0.90 AI916544 1.00 1.00 1.00 1
50795_at2, 3 U95-B 1 1.00 1.00 0.80 1.12 AI693592 0.40 1.00 0.76 1

226552_at2, 3 U133-B 1 1.00 1.00 -- -- BF110608 0.20 1.00 0.72 1

226559_at2, 3 U133-B 1 1.00 1.00 -- -- AL555612 0.80 1.00 0.91 1

226552_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226559_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  IER5L for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCGGCCAGCG

SOURCE GeneReport for Unigene clusters: Hs.529857 Hs.640233
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IER5L gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
IER5L1   -- immediate early response 5-like 96.99(n)
98.25(a)
491302  XM_548423.2  XP_548423.2 
chimpanzee
(Pan troglodytes)
IER5L1   -- immediate early response 5-like 97.93(n)
96.27(a)
464786  XM_520307.2  XP_520307.2 
cow
(Bos taurus)
IER5L1   -- immediate early response 5-like 96.38(n)
96.72(a)
782019  XM_001250147.1  XP_001250148.1 
rat
(Rattus norvegicus)
Ier5l1   -- immediate early response 5-like 95.17(n)
96.25(a)
499772  NM_001025041.1  NP_001020212.1 
mouse
(Mus musculus)
Ier5l1, 5 25
immediate early response 5-like1, 5 94.57(n)1
95.99(a)1
725001  NM_030244.31  NP_084520.31 
 AK0121455  AK0340555  (see all 11)
About this table        Species with no ortholog for IER5L

ENSEMBL Gene Tree for IER5L
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for IER5L gene
IER52  IER22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/30 NCBI SNPs in IER5L are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 64)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs8826161,2
A,C,F,H130980686(-) CTCCCG/AGGACC 1 -- ng314Minor allele frequency- A:0.17EU EA WA 418
--
rs70341951,2
A,C,F,H130981130(+) GCTCAC/AAGGCG 1 -- ng314Minor allele frequency- A:0.39EU EA WA 416
rs11071851,2
A,C,F,H130980252(+) gcAGGG/CGTAAC 1 -- ut51 ese35Minor allele frequency- C:0.02MN EU EA WA 602
--
rs24804461,2
C,F,H130981132(-) GACGCC/TTTTGA 1 -- ng314Minor allele frequency- T:0.04EU EA WA 418
rs13295881,2
C,F,H130980459(-) CTGCGC/ACTGTC 1 -- ng316Minor allele frequency- A:0.17MN EU EA WA 778
rs1844571,2
A,C,H130979840(+) GGCCGA/GCTCGC 1 P/S mis14Minor allele frequency- G:0.37MN EA WA 480
rs24804451,2
C,F,H130981388(-) CGTCTG/CGAGCG 1 -- ng314Minor allele frequency- C:0.04EU EA WA 418
rs10756501,2
C,F,H130978734(-) CAGAGA/GGAAAA 1 -- ut31 ese3 trp36Minor allele frequency- G:0.15EU EA WA MN 1902
rs117907771,2
C,H130981233(+) TTATGG/AGCCTA 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
rs109882381,2
C,H130982083(+) TGGTGC/GTGTGT 1 -- ng315Minor allele frequency- G:0.00EU EA WA 598
About this table

HapMap Linkage Disequilibrium images for IER5L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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6 PubMed articles for IER5L gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 389792 HGNC: 23679 AceView: IER5L Ensembl:ENSG00000188483 euGenes: HUgn389792
ECgene: IER5L H-InvDB: IER5L
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IER5L:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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