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Aliases for IER5L Gene

Aliases for IER5L Gene

  • Immediate Early Response 5 Like 2 3 5
  • Immediate Early Response Gene 5-Like Protein 3
  • BA247A12.2 3

External Ids for IER5L Gene

Previous GeneCards Identifiers for IER5L Gene

  • GC09M129018
  • GC09M130977
  • GC09M131937
  • GC09M101545

Summaries for IER5L Gene

GeneCards Summary for IER5L Gene

IER5L (Immediate Early Response 5 Like) is a Protein Coding gene. An important paralog of this gene is IER5.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5L Gene

Genomics for IER5L Gene

Regulatory Elements for IER5L Gene

Enhancers for IER5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G129342 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -167.1 -167140 6.0 FOXA2 MLX ARID4B DMAP1 ZNF48 TCF12 SLC30A9 FOS SP5 MXD4 IER5L LOC105376289 NTMT1 C9orf50 LINC01503 C9orf106 CERCAM C9orf78 TOR1B RN7SL159P
GH09G129555 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -379.7 -379680 4.1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZBTB7B YY1 SLC30A9 PAF1 SP5 NTMT1 C9orf50 IER5L LOC105376289 PKN3 DOLPP1 LOC105376292 LINC00963
GH09G129224 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -47.1 -47101 2.3 CTCF SIN3A MAX ZIC2 RAD21 ZKSCAN1 ZNF121 ZFHX2 ZNF366 ZSCAN5C IER5L LOC105376289 C9orf50 NTMT1 CRAT CERCAM GC09M129195 LOC105376290
GH09G129202 1.5 Ensembl ENCODE dbSUPER 13.1 -24.8 -24800 1.5 PKNOX1 ATF1 CREB3L1 YY1 ETS1 ZNF766 ELK1 ZNF143 KDM4B DEK IER5L LOC105376289 CRAT ENSG00000268707 CIZ1 GC09M129195 LOC105376290
GH09G129317 1.6 Ensembl ENCODE dbSUPER 11.6 -142.6 -142560 7.2 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 LOC105376289 IER5L ENSG00000234055 ENSG00000273186 SH3GLB2 C9orf106 LOC101929331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IER5L on UCSC Golden Path with GeneCards custom track

Promoters for IER5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241963 1962 4601 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A

Genomic Location for IER5L Gene

129,175,552 bp from pter
129,178,262 bp from pter
2,711 bases
Minus strand

Genomic View for IER5L Gene

Genes around IER5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5L Gene

Proteins for IER5L Gene

  • Protein details for IER5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immediate early response gene 5-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6P3E2

    Protein attributes for IER5L Gene

    404 amino acids
    Molecular mass:
    42109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IER5L Gene


neXtProt entry for IER5L Gene

Post-translational modifications for IER5L Gene

No Post-translational modifications

Other Protein References for IER5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5L Gene

Domains & Families for IER5L Gene

Protein Domains for IER5L Gene

Suggested Antigen Peptide Sequences for IER5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IER family.
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5L: view

No data available for Gene Families for IER5L Gene

Function for IER5L Gene

Phenotypes for IER5L Gene

GenomeRNAi human phenotypes for IER5L:
genes like me logo Genes that share phenotypes with IER5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IER5L Gene

Localization for IER5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER5L gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5L Gene

Pathways & Interactions for IER5L Gene

SuperPathways for IER5L Gene

No Data Available

Interacting Proteins for IER5L Gene

Gene Ontology (GO) - Biological Process for IER5L Gene


No data available for Pathways by source and SIGNOR curated interactions for IER5L Gene

Drugs & Compounds for IER5L Gene

No Compound Related Data Available

Transcripts for IER5L Gene

mRNA/cDNA for IER5L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(123) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5L Gene

Immediate early response 5-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER5L Gene

No ASD Table

Relevant External Links for IER5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IER5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IER5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5L Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IER5L Gene

Protein tissue co-expression partners for IER5L Gene

NURSA nuclear receptor signaling pathways regulating expression of IER5L Gene:


SOURCE GeneReport for Unigene cluster for IER5L Gene:

genes like me logo Genes that share expression patterns with IER5L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER5L Gene

Orthologs for IER5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IER5L 34 35
  • 93.23 (n)
(Bos Taurus)
Mammalia IER5L 34 35
  • 92.93 (n)
(Rattus norvegicus)
Mammalia Ier5l 34
  • 92.58 (n)
(Mus musculus)
Mammalia Ier5l 34 16 35
  • 92.56 (n)
(Monodelphis domestica)
Mammalia IER5L 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ier5l 34
  • 74.83 (n)
MGC75980 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33398 34
(Danio rerio)
Actinopterygii ier5l 34 35
  • 68.46 (n)
wufe50b07 34
Species where no ortholog for IER5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5L Gene

Gene Tree for IER5L (if available)
Gene Tree for IER5L (if available)

Paralogs for IER5L Gene

Paralogs for IER5L Gene

genes like me logo Genes that share paralogs with IER5L: view

Variants for IER5L Gene

Sequence variations from dbSNP and Humsavar for IER5L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000208113 -- 129,177,865(+) GCTGT(-/TGCTGC)TGCTG cds-indel
rs1000239133 -- 129,177,641(+) CGCCG(C/T)GCAGC reference, missense
rs1000489864 -- 129,178,070(+) ACGGC(C/G)GCGGA utr-variant-5-prime
rs1001110391 -- 129,177,020(+) CGAGT(A/C)CGGGC reference, missense
rs1001190649 -- 129,178,576(+) CCTCG(C/T)CTTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IER5L Gene

Variant ID Type Subtype PubMed ID
esv2675916 CNV deletion 23128226
nsv1137668 CNV deletion 24896259
nsv1144292 CNV deletion 24896259
nsv466578 CNV loss 19166990
nsv615417 CNV loss 21841781
nsv615418 CNV loss 21841781
nsv818725 CNV gain 17921354
nsv825108 CNV gain 20364138
nsv825110 CNV gain 20364138
nsv825111 CNV gain 20364138

Variation tolerance for IER5L Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5L Gene

Disorders for IER5L Gene

Relevant External Links for IER5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IER5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5L Gene

Publications for IER5L Gene

  1. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for IER5L Gene

Sources for IER5L Gene

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