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IER5L Gene

protein-coding   GIFtS: 41
GCID: GC09M131937

Immediate Early Response 5-Like

  Search for IER5L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immediate Early Response 5-Like1 2
bA247A12.22
Immediate Early Response Gene 5-Like Protein2

External Ids:    HGNC: 236791   Entrez Gene: 3897922   Ensembl: ENSG000001884837   UniProtKB: Q5T9533   

Export aliases for IER5L gene to outside databases

Previous GC identifers: GC09M129018 GC09M130977 GC09M101545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IER5L Gene:
IER5L (immediate early response 5-like) is a protein-coding gene. An important paralog of this gene is IER5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IER5L gene promoter:
         NF-1/L   NF-1   Pax-5   Egr-1   p300   YY1   GATA-2   Egr-2   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER5L promoter sequence
   Search Chromatin IP Primers for IER5L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IER5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

IER5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER5L gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131937:  view genomic region     (about GC identifiers)

Start:
131,937,831 bp from pter      End:
131,940,540 bp from pter
Size:
2,710 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953 (See protein sequence)
Recommended Name: Immediate early response gene 5-like protein  
Size: 404 amino acids; 42109 Da
Secondary accessions: Q6P3E2
Alternative splicing: 2 isoforms:  Q5T953-1   Q5T953-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IER5L: NX_Q5T953

Explore proteomics data for IER5L at MOPED


See IER5L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_982258.2  
ENSEMBL proteins: 
 ENSP00000361569  

IER5L Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008653 IER

Graphical View of Domain Structure for InterPro Entry Q5T953

ProtoNet protein and cluster: Q5T953

UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953
Similarity: Belongs to the IER family


IER5L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for IER5L:
 Increased cell number in G1, a 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IER5L
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Selected qRT-PCR Assays for microRNAs that regulate IER5L (see all 53):
hsa-miR-549 hsa-miR-142-5p hsa-miR-4328 hsa-miR-300 hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-146a hsa-miR-765
SwitchGear 3'UTR luciferase reporter plasmidIER5L 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat IER5L

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER5L

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER5L


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol1
extracellular1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IER5L
Interactions:

    Search GeneGlobe Interaction Network for IER5L

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IER5L (ENSP000003615694) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IER5L



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IER5L gene: 
NM_203434.2  

Unigene Cluster for IER5L:

Immediate early response 5-like
Hs.529857  [show with all ESTs]
Unigene Representative Sequence: NM_203434
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000372491(uc010myt.1)
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate IER5L (see all 53):
hsa-miR-549 hsa-miR-142-5p hsa-miR-4328 hsa-miR-300 hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-146a hsa-miR-765
SwitchGear 3'UTR luciferase reporter plasmidIER5L 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IER5L
Predesigned siRNA for gene silencing in human, mouse, rat IER5L
Clone
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OriGene ORF clones in mouse, rat for IER5L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IER5L (NM_203434)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER5L
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IER5L
  QuantiTect SYBR Green Assays in human, mouse, rat IER5L
  QuantiFast Probe-based Assays in human, mouse, rat IER5L

Additional mRNA sequence: 

BC013070.1 BC064028.1 

4 DOTS entries:

DT.437639  DT.307819  DT.100686737  DT.100820935 

Selected AceView cDNA sequences (see all 123):

BM848412 BM761092 BE550112 BQ086229 BM763373 BM851449 BM768171 BM699517 
CF127075 AI912541 BM845162 CR610382 AA609471 BQ574938 BC013070 BM767548 
AI991369 CK822923 BE551629 AW104728 BM768187 BM781986 AI693592 BM818550 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IER5L expression in normal human tissues (normalized intensities)      IER5L embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCGGCCAGCG
IER5L Expression
About this image


IER5L expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
         Floor plate-like cells
 
 Limb (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
 
 Neural Ectoderm (Nervous System)
         Neural ectoderm cells
 
 Bone (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
 
 Cartilage (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
IER5L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IER5L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.529857
    Custom PCR Arrays for IER5L
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IER5L
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER5L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IER5L gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ier5l1 , 5 immediate early response 5-like1, 5 92.56(n)1
92.73(a)1
  2 (21.71 cM)5
725001  NM_030244.31  NP_084520.31 
 304715375 
African clawed frog
(Xenopus laevis)
Amphibia Xl.333982 Xenopus laevis transcribed sequence with weak similarity more 85.69(n)    BJ624163.1 
zebrafish
(Danio rerio)
Actinopterygii wufe50b072 wufe50b07 77.96(n)   326935  BC059641.1 


ENSEMBL Gene Tree for IER5L (if available)
TreeFam Gene Tree for IER5L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IER5L gene
IER52  

IER5L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IER5L (see all 103)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs174867991,2
C--131937525(+) CGCCTG/CTGCCT 1 -- int13Minor allele frequency- C:0.19WA EA 240
rs174868061,2
C,F,H--131937734(+) CCGAAG/AAGAAC 1 -- int16Minor allele frequency- A:0.02NS EA CSA WA 538
rs283655811,2
H--131937943(+) GGGCCG/AAGAAA 1 -- ut31 ese3 trp34Minor allele frequency- A:0.00NS EA 418
rs38311801,2
C--131938053(-) GATTT-/GTTT  
        
AATTT
2 -- ut31 cds11Minor allele frequency- GTTT:0.50CSA 2
rs1417804961,2
C--131938053(+) AAATT-/AAAC  
        
AAATC
1 -- ut310--------
rs783781941,2
C--131938056(+) TTAAAC/TAAATC 1 -- ut310--------
rs1451683281,2
C--131938162(+) AGAAG-/CACACAC 1 -- ut310--------
rs59008331,2
C--131938357(+) TTACCCAAA/-  
        
CAGTG
1 -- ut311Minor allele frequency- -:0.00CSA 2
rs283655821,2
C--131938357(+) CTTACA/CCAGTG 1 -- ut31 ese30--------
rs339568781,2
C--131938358(+) TACCC-/CAA   
   
/CAAA
AGTGT
2 -- cds1 ut310--------

HapMap Linkage Disequilibrium report for IER5L (131937831 - 131940540 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for IER5L:    About this table    
Variant IDTypeSubtypePubMed ID
esv2675916CNV Deletion23128226
nsv466578CNV Loss19166990
nsv893909CNV Loss21882294
nsv825110CNV Gain20364138
nsv825108CNV Gain20364138
nsv825111CNV Gain20364138
nsv818725CNV Gain17921354

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for IER5L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IER5L gene integrated from 10 sources:
(articles sorted by number of sources associating them with IER5L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
  2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  3. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 389792 HGNC: 23679 AceView: IER5L Ensembl:ENSG00000188483 euGenes: HUgn389792
ECgene: IER5L H-InvDB: IER5L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IER5L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IER5L gene:
Search GeneIP for patents involving IER5L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER5L
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IER5L
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IER5L
 LSBio Antibodies in human, mouse, rat for IER5L
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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