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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IER5L Gene

protein-coding GIFtS: 39
GCID: GC09M131937

immediate early response 5-like

Search for IER5L
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immediate Early Response 5-Like¹ ²
BA247A12.2¹
Immediate Early Response Gene 5-Like Protein²

External Ids:	HGNC: 23679¹	Entrez Gene: 389792²	Ensembl: ENSG00000188483⁷	UniProtKB: Q5T953³

Export aliases for IER5L gene to outside databases

Previous GC identifers: GC09M129018 GC09M130977 GC09M101545

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IER5L gene promoter:
NF-1/L NF-1 Pax-5 Egr-1 p300 YY1 GATA-2 Egr-2 MEF-2A aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER5L promoter sequence

Search SABiosciences Chromatin IP Primers for IER5L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IER5L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC chromosome: 9

IER5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER5L gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M131937: view genomic region (about GC identifiers)

Start:	131,937,831 bp from pter	End:	131,940,540 bp from pter
Size:	2,710 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953 (See protein sequence)

Recommended Name: Immediate early response gene 5-like protein

Size: 404 amino acids; 42109 Da

Secondary accessions: Q6P3E2

Alternative splicing: 2 isoforms: Q5T953-1 Q5T953-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IER5L: NX_Q5T953

IER5L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_982258.2

ENSEMBL proteins:

ENSP00000361569

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IER5L for domains About GeneDecksing

1 InterPro domain/family:

IPR008653 IER

Graphical View of Domain Structure for InterPro Entry Q5T953

ProtoNet protein and cluster: Q5T953

UniProtKB/Swiss-Prot: IER5L_HUMAN, Q5T953

Similarity: Belongs to the IER family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for IER5L:

Increased cell number in G1, a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IER5L

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IER5L (ENSP00000361569⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for IER5L
Search CenterWatch for drugs/clinical trials and news about IER5L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IER5L gene:

NM_203434.2

Unigene Cluster for IER5L:

Immediate early response 5-like

Hs.529857 [show with all ESTs]

Unigene Representative Sequence: NM_203434

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000372491(uc010myt.1)

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		SwitchGear 3'UTR luciferase reporter plasmid: IER5L 3' UTR sequence

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Additional cDNA sequence:

BC013070.1 BC064028.1

4 DOTS entries:

DT.437639 DT.307819 DT.100686737 DT.100820935

24/123 AceView cDNA sequences (see all 123):

BM850200 AI991369 BM795407 BM848412 BE550112 BM845162 BM768189 CK822923

AW104728 BM848377 BM763373 BE218829 BC013070 BQ071193 BM821325 BM767794

AA609471 BM768187 BM851449 BM768171 BM699517 AI912541 BM849169 BQ086229

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IER5L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGGCCAGCG

About this image

IER5L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Hypothalamus

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

See IER5L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IER5L

SOURCE GeneReport for Unigene cluster: Hs.529857

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IER5L gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Ier5l^{1 , 5}	immediate early response 5-like^{1, 5}	94.57(n)¹ 95.99(a)¹	2 (21.71 cM)⁵ 72500¹ NM_030244.3¹ NP_084520.3¹ 30471537⁵
African clawed frog (Xenopus laevis)	Amphibia	Xl.33398²	Xenopus laevis transcribed sequence with weak similarity more	85.69(n)	BJ624163.1
zebrafish (Danio rerio)	Actinopterygii	wufe50b07²	wufe50b07	77.96(n)	326935 BC059641.1

ENSEMBL Gene Tree for IER5L (if available)
TreeFam Gene Tree for IER5L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IER5L gene

IER5² IER2²

IER5L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17486799^1,2	C,	--	131937525(+)	`CGCCTG/CTGCCT`	1	--	int¹		3		WA EA	240
rs17486806^1,2	C,F,H,	--	131937734(+)	`CCGAAG/AAGAAC`	1	--	int¹		6		NS EA CSA WA	538
rs28365581^1,2	H	--	131937943(+)	`GGGCCG/AAGAAA`	1	--	ut3¹ ese³ trp³		4		NS EA	418
rs3831180^1,2	C	--	131938053(-)	`GATTT-/GTTT AATTT`	2	--	ut3¹		1		CSA	2
rs141780496^1,2	C,	--	131938053(+)	`AAATT-/AAAC AAATC`	1	--	ut3¹		0	--	--	--	--
rs78378194^1,2	C,	--	131938056(+)	`TTAAAC/TAAATC`	1	--	ut3¹		0	--	--	--	--
rs145168328^1,2		--	131938162(+)	`AGAAG-/CACACAC`	1	--	ut3¹		0	--	--	--	--
rs5900833^1,2	C,	--	131938357(+)	`TTACCCAAA/- CAGTG`	1	--	ut3¹		1		CSA	2
rs28365582^1,2	C	--	131938357(+)	`CTTACA/CCAGTG`	1	--	ut3¹ ese³		0	--	--	--	--
rs185642126^1,2		--	131938420(+)	`AGGAGA/GGGAGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IER5L (131937831 - 131940540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IER5L
1 CNV: 9623

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IER5L gene integrated from 9 sources:
(articles sorted by number of sources associating them with IER5L)

Utopia: connect your pdf to the dynamic
world of online information

Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H....Kim N.S. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389792	HGNC: 23679	AceView: IER5L	Ensembl:ENSG00000188483	euGenes: HUgn389792
ECgene: IER5L	H-InvDB: IER5L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IER5L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IER5L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IER5L gene:
Search GeneIP for patents involving IER5L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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IER5L Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER5L

	SwitchGear 3'UTR luciferase reporter plasmids for IER5L
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER5L

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IER5L gene at Home site.

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IER5L Gene

immediate early response 5-like

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Export list of displayed genes

IER5L Gene

immediate early response 5-like

Aliasesfor IER5L gene

Summariesfor IER5L gene

Genomic Viewsfor IER5L gene

Proteinsfor IER5L gene

Protein Domains /Familiesfor IER5L gene

Functionfor IER5L gene

Pathways & Interactionsfor IER5L gene

Drugs & Compoundsfor IER5L gene

Transcriptsfor IER5L gene

Expression for IER5L gene

Orthologsfor IER5L gene

Paralogsfor IER5L gene

Genomic Variantsfor IER5L gene

Disorders / Diseasesfor IER5L gene

Publicationsfor IER5L gene

External Searches for IER5L gene

Genome Databases showing IER5L gene

Other Databases showing IER5L gene

Specialized Databases showing IER5L gene

Intellectual Propertyfor IER5L gene

Productsfor IER5L gene

View Random Gene

Aliases
for IER5L gene

Summaries
for IER5L gene

Genomic Views
for IER5L gene

Proteins
for IER5L gene

Protein Domains /
Families
for IER5L gene

Function
for IER5L gene

Pathways & Interactions
for IER5L gene

Drugs & Compounds
for IER5L gene

Transcripts
for IER5L gene

Expression
for IER5L gene

Orthologs
for IER5L gene

Paralogs
for IER5L gene

Genomic Variants
for IER5L gene

Disorders / Diseases
for IER5L gene

Publications
for IER5L gene

Intellectual Property
for IER5L gene

Products
for IER5L gene