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Aliases for IER5 Gene

Aliases for IER5 Gene

  • Immediate Early Response 5 2 3 5
  • Immediate Early Response Gene 5 Protein 3
  • SBBI48 3

External Ids for IER5 Gene

Previous GeneCards Identifiers for IER5 Gene

  • GC01P178581
  • GC01P176486
  • GC01P177578
  • GC01P178297
  • GC01P177789
  • GC01P179324
  • GC01P181057
  • GC01P152288

Summaries for IER5 Gene

Entrez Gene Summary for IER5 Gene

  • This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IER5 Gene

IER5 (Immediate Early Response 5) is a Protein Coding gene. An important paralog of this gene is IER5L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5 Gene

Genomics for IER5 Gene

Regulatory Elements for IER5 Gene

Enhancers for IER5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F181158 1.6 FANTOM5 Ensembl ENCODE 22.9 +71.9 71899 3.6 HDGF PKNOX1 ARNT ZNF493 ZNF121 GATA2 FOS ZNF548 KDM4B MCM5 LHX4 IER5 ACBD6 MR1 KIAA1614 STX6 LINC01732 GC01M181116
GH01F181126 1.9 FANTOM5 Ensembl ENCODE 16.7 +43.4 43418 11.4 FEZF1 DMAP1 YBX1 ZNF548 ZNF263 SP3 TBX21 ZFP41 MEF2D ZNF610 LHX4 ACBD6 IER5 ENSG00000225359 ENSG00000232309 MR1 KIAA1614 STX6 GC01M181116 LINC01732
GH01F181086 1.6 FANTOM5 ENCODE 18.4 +4.1 4061 11.6 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 LHX4 IER5 ENSG00000225359 MR1 ACBD6 KIAA1614 STX6 GC01M181092 GC01M181116
GH01F181148 2.2 VISTA FANTOM5 Ensembl ENCODE 12.3 +63.0 62959 6.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 CBX5 ZNF207 FOS IER5 MR1 ACBD6 KIAA1614 LOC105371638 ENSG00000243155 LINC01732 GC01M181116
GH01F181138 1.7 FANTOM5 Ensembl ENCODE 15.9 +52.5 52499 4.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS KLF13 IER5 STX6 MR1 GC01M181116 LINC01732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IER5 on UCSC Golden Path with GeneCards custom track

Promoters for IER5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000548658 1698 4401 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for IER5 Gene

181,088,502 bp from pter
181,092,899 bp from pter
4,398 bases
Plus strand

Genomic View for IER5 Gene

Genes around IER5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5 Gene

Proteins for IER5 Gene

  • Protein details for IER5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immediate early response gene 5 protein
    Protein Accession:
    Secondary Accessions:
    • B2RBV3
    • Q8WY68
    • Q9NY49
    • Q9NZP9

    Protein attributes for IER5 Gene

    327 amino acids
    Molecular mass:
    33704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IER5 Gene

Post-translational modifications for IER5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IER5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5 Gene

Domains & Families for IER5 Gene

Protein Domains for IER5 Gene


Suggested Antigen Peptide Sequences for IER5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IER family.
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5: view

No data available for Gene Families for IER5 Gene

Function for IER5 Gene

Gene Ontology (GO) - Molecular Function for IER5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25816751
GO:0042802 identical protein binding IPI 26496226
genes like me logo Genes that share ontologies with IER5: view
genes like me logo Genes that share phenotypes with IER5: view

Animal Model Products

miRNA for IER5 Gene

miRTarBase miRNAs that target IER5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER5 Gene

Localization for IER5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5 Gene

Pathways & Interactions for IER5 Gene

No Data Available

Interacting Proteins for IER5 Gene

Gene Ontology (GO) - Biological Process for IER5 Gene


No data available for Pathways by source and SIGNOR curated interactions for IER5 Gene

Transcripts for IER5 Gene

mRNA/cDNA for IER5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5 Gene

Immediate early response 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER5 Gene

No ASD Table

Relevant External Links for IER5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IER5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IER5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5 Gene

This gene is overexpressed in Placenta (42.4) and Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IER5 Gene

Protein tissue co-expression partners for IER5 Gene

NURSA nuclear receptor signaling pathways regulating expression of IER5 Gene:


SOURCE GeneReport for Unigene cluster for IER5 Gene:

genes like me logo Genes that share expression patterns with IER5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IER5 Gene

Orthologs for IER5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IER5 34 35
  • 98.67 (n)
(Bos Taurus)
Mammalia IER5 34 35
  • 85.51 (n)
(Mus musculus)
Mammalia Ier5 34 16 35
  • 81.47 (n)
(Rattus norvegicus)
Mammalia Ier5 34
  • 80.15 (n)
(Canis familiaris)
Mammalia IER5 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia IER5 35
  • 54 (a)
(Gallus gallus)
Aves IER5 34 35
  • 64.14 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7086 34
(Danio rerio)
Actinopterygii ier5 34 35
  • 48.87 (n)
wufb04b03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9060 34
Species where no ortholog for IER5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5 Gene

Gene Tree for IER5 (if available)
Gene Tree for IER5 (if available)

Paralogs for IER5 Gene

Paralogs for IER5 Gene

genes like me logo Genes that share paralogs with IER5: view

Variants for IER5 Gene

Sequence variations from dbSNP and Humsavar for IER5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1045078 -- 181,090,680(+) GAAAG(A/C)CCTTA utr-variant-3-prime
rs10910865 -- 181,086,801(+) gggat(C/T)acagg upstream-variant-2KB
rs10910866 -- 181,088,141(+) ACTCT(A/C)GCGGG upstream-variant-2KB
rs112046405 -- 181,086,859(+) AGACA(C/G)GGTTT upstream-variant-2KB
rs113028155 -- 181,089,136(+) GCCGG(G/T)CCACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IER5 Gene

Variant ID Type Subtype PubMed ID
nsv548357 CNV gain 21841781
nsv548356 CNV loss 21841781
esv22385 CNV loss 19812545

Variation tolerance for IER5 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5 Gene

Disorders for IER5 Gene

Relevant External Links for IER5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IER5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5 Gene

Publications for IER5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. Gene expression in the brain across the sleep-waking cycle. (PMID: 11102586) Cirelli C. … Tononi G. (Brain Res. 2000) 2 3 64
  5. Ier5, a novel member of the slow-kinetics immediate-early genes. (PMID: 10049588) Williams M. … Hunter K. (Genomics 1999) 2 3 64

Products for IER5 Gene

Sources for IER5 Gene

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