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Aliases for IER5 Gene

Aliases for IER5 Gene

  • Immediate Early Response 5 2 3 5
  • Immediate Early Response Gene 5 Protein 3
  • SBBI48 3

External Ids for IER5 Gene

Previous GeneCards Identifiers for IER5 Gene

  • GC01P178581
  • GC01P176486
  • GC01P177578
  • GC01P178297
  • GC01P177789
  • GC01P179324
  • GC01P181057
  • GC01P152288

Summaries for IER5 Gene

Entrez Gene Summary for IER5 Gene

  • This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IER5 Gene

IER5 (Immediate Early Response 5) is a Protein Coding gene. An important paralog of this gene is IER5L.

UniProtKB/Swiss-Prot for IER5 Gene

  • Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5 Gene

Genomics for IER5 Gene

Regulatory Elements for IER5 Gene

Enhancers for IER5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G181086 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.4 +4.1 4061 11.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 IER5 MR1 ACBD6 KIAA1614 LHX4 STX6 GC01M181092 GC01M181116
GH01G181159 1.6 FANTOM5 Ensembl ENCODE 22.9 +72.1 72092 3.2 HDGF PKNOX1 ARNT FOS ZNF548 MCM5 JUNB REST TBX21 MEF2D IER5 MR1 ACBD6 KIAA1614 STX6 LINC01732 GC01M181116
GH01G181126 2 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +40.8 40835 6.2 FEZF1 ZNF548 ZNF263 TBX21 MEF2D ZNF610 GLIS1 NBN NR2C1 KDM1A ACBD6 LHX4 KIAA1614 IER5 MR1 GC01M181116 LINC01732
GH01G181132 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +46.4 46414 4.4 DMAP1 YBX1 ZNF548 ZNF263 SP3 TBX21 ZFP41 MEF2D ZNF585B GLIS1 LHX4 IER5 ACBD6 KIAA1614 MR1 STX6 GC01M181116 LINC01732
GH01G181139 2 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +52.7 52698 4.0 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS IER5 STX6 MR1 GC01M181116 LINC01732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IER5 on UCSC Golden Path with GeneCards custom track

Promoters for IER5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016616 1498 3201 MLX AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for IER5 Gene

Chromosome:
1
Start:
181,088,502 bp from pter
End:
181,092,899 bp from pter
Size:
4,398 bases
Orientation:
Plus strand

Genomic View for IER5 Gene

Genes around IER5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5 Gene

Proteins for IER5 Gene

  • Protein details for IER5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VY09-IER5_HUMAN
    Recommended name:
    Immediate early response gene 5 protein
    Protein Accession:
    Q5VY09
    Secondary Accessions:
    • B2RBV3
    • Q8WY68
    • Q9NY49
    • Q9NZP9

    Protein attributes for IER5 Gene

    Size:
    327 amino acids
    Molecular mass:
    33704 Da
    Quaternary structure:
    • Monomer (PubMed:26496226). Homodimer (PubMed:26496226). Associates with the catalytic subunit of protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Interacts (via N- and C-terminal regions) with PPP2R2B (PubMed:25816751, PubMed:26496226). Interacts with PPP2R2A, PPP2R2C and PPP2R2D (PubMed:25816751). Interacts (via N-terminus) with RPS6KB1 (PubMed:26496226). Interacts (via central region) with HSF1; this interaction promotes PPP2CA-induced HSF1 dephosphorylation, leading to enhanced HSF1 transcriptional activity (PubMed:25816751, PubMed:26496226, PubMed:26754925).

neXtProt entry for IER5 Gene

Post-translational modifications for IER5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IER5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5 Gene

Domains & Families for IER5 Gene

Protein Domains for IER5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IER5 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VY09

UniProtKB/Swiss-Prot:

IER5_HUMAN :
  • Belongs to the IER family.
Family:
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5: view

No data available for Gene Families for IER5 Gene

Function for IER5 Gene

Molecular function for IER5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).
UniProtKB/Swiss-Prot Induction:
Up-regulated by heat shock in a heat shock HSF1-dependent manner (PubMed:25355627). Up-regulated by ionizing radiation (PubMed:19238419).

Gene Ontology (GO) - Molecular Function for IER5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25816751
GO:0042802 identical protein binding IPI 26496226
genes like me logo Genes that share ontologies with IER5: view
genes like me logo Genes that share phenotypes with IER5: view

Animal Model Products

CRISPR Products

miRNA for IER5 Gene

miRTarBase miRNAs that target IER5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER5 Gene

Localization for IER5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IER5 Gene

Nucleus. Cytoplasm. Note=Predominantly cytoplasmic (PubMed:25816751). Translocated in the nucleus during heat shock (PubMed:25816751). {ECO:0000269 PubMed:25816751}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IER5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 25816751
GO:0005634 nucleus IDA 25816751
GO:0005737 cytoplasm IDA 25816751
genes like me logo Genes that share ontologies with IER5: view

Pathways & Interactions for IER5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IER5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0034605 cellular response to heat IDA 25816751
GO:0042127 regulation of cell proliferation IMP 26496226
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 25816751
GO:1900036 positive regulation of cellular response to heat IMP 26496226
genes like me logo Genes that share ontologies with IER5: view

No data available for Pathways by source and SIGNOR curated interactions for IER5 Gene

Drugs & Compounds for IER5 Gene

No Compound Related Data Available

Transcripts for IER5 Gene

mRNA/cDNA for IER5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5 Gene

Immediate early response 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER5 Gene

No ASD Table

Relevant External Links for IER5 Gene

GeneLoc Exon Structure for
IER5
ECgene alternative splicing isoforms for
IER5

Expression for IER5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IER5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5 Gene

This gene is overexpressed in Placenta (42.4) and Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IER5 Gene



Protein tissue co-expression partners for IER5 Gene

NURSA nuclear receptor signaling pathways regulating expression of IER5 Gene:

IER5

SOURCE GeneReport for Unigene cluster for IER5 Gene:

Hs.15725

mRNA Expression by UniProt/SwissProt for IER5 Gene:

Q5VY09-IER5_HUMAN
Tissue specificity: Expressed in acute myeloid leukemia (AML) cells.

Evidence on tissue expression from TISSUES for IER5 Gene

  • Blood(4.3)
  • Spleen(4.3)
  • Lymph node(4.2)
  • Stomach(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with IER5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER5 Gene

Orthologs for IER5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IER5 34 35
  • 98.67 (n)
cow
(Bos Taurus)
Mammalia IER5 34 35
  • 85.51 (n)
mouse
(Mus musculus)
Mammalia Ier5 34 16 35
  • 81.47 (n)
rat
(Rattus norvegicus)
Mammalia Ier5 34
  • 80.15 (n)
dog
(Canis familiaris)
Mammalia IER5 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IER5 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves IER5 34 35
  • 64.14 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7086 34
zebrafish
(Danio rerio)
Actinopterygii ier5 34 35
  • 48.87 (n)
wufb04b03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9060 34
Species where no ortholog for IER5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5 Gene

ENSEMBL:
Gene Tree for IER5 (if available)
TreeFam:
Gene Tree for IER5 (if available)

Paralogs for IER5 Gene

Paralogs for IER5 Gene

genes like me logo Genes that share paralogs with IER5: view

Variants for IER5 Gene

Sequence variations from dbSNP and Humsavar for IER5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001032830 -- 181,086,832(+) TAATT(A/T)CTGTA upstream-variant-2KB
rs1001106473 -- 181,087,082(+) TCCTC(A/G)GCCTG upstream-variant-2KB
rs1001332719 -- 181,087,671(+) ACCCC(A/G)TGGTA upstream-variant-2KB
rs1001659572 -- 181,087,267(+) AGAGC(C/T)TGCTG upstream-variant-2KB
rs1003594739 -- 181,088,667(+) AGAAG(C/G)CTATA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IER5 Gene

Variant ID Type Subtype PubMed ID
esv22385 CNV loss 19812545
nsv548356 CNV loss 21841781
nsv548357 CNV gain 21841781

Variation tolerance for IER5 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IER5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5 Gene

Disorders for IER5 Gene

Relevant External Links for IER5

Genetic Association Database (GAD)
IER5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IER5

No disorders were found for IER5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5 Gene

Publications for IER5 Gene

  1. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. (PMID: 26754925) Asano Y. … Ohki R. (Sci Rep 2016) 3 4 64
  2. Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells. (PMID: 25355627) Ishikawa Y. … Sakurai H. (FEBS J. 2015) 3 4 64
  3. HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y. … Sakurai H. (FEBS Lett. 2015) 3 4 64
  4. Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1. (PMID: 26496226) Kawabata S. … Sakurai H. (FEBS Lett. 2015) 3 4 64
  5. Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia. (PMID: 22132193) Nakamura S. … Yamashita M. (PLoS ONE 2011) 3 4 64

Products for IER5 Gene

Sources for IER5 Gene

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