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Aliases for IER5 Gene

Aliases for IER5 Gene

  • Immediate Early Response 5 2 3 5
  • SBBI48 3

External Ids for IER5 Gene

Previous GeneCards Identifiers for IER5 Gene

  • GC01P178581
  • GC01P176486
  • GC01P177578
  • GC01P178297
  • GC01P177789
  • GC01P179324
  • GC01P181057
  • GC01P152288

Summaries for IER5 Gene

Entrez Gene Summary for IER5 Gene

  • This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IER5 Gene

IER5 (Immediate Early Response 5) is a Protein Coding gene. An important paralog of this gene is IER5L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5 Gene

Genomics for IER5 Gene

Regulatory Elements for IER5 Gene

Enhancers for IER5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IER5 on UCSC Golden Path with GeneCards custom track

Promoters for IER5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IER5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IER5 Gene

181,088,502 bp from pter
181,092,899 bp from pter
4,398 bases
Plus strand

Genomic View for IER5 Gene

Genes around IER5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5 Gene

Proteins for IER5 Gene

  • Protein details for IER5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immediate early response gene 5 protein
    Protein Accession:
    Secondary Accessions:
    • B2RBV3
    • Q8WY68
    • Q9NY49
    • Q9NZP9

    Protein attributes for IER5 Gene

    327 amino acids
    Molecular mass:
    33704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IER5 Gene

Proteomics data for IER5 Gene at MOPED

Post-translational modifications for IER5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IER5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5 Gene

Domains & Families for IER5 Gene

Protein Domains for IER5 Gene


Suggested Antigen Peptide Sequences for IER5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IER family.
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5: view

No data available for Gene Families for IER5 Gene

Function for IER5 Gene

Gene Ontology (GO) - Molecular Function for IER5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 26496226
genes like me logo Genes that share ontologies with IER5: view
genes like me logo Genes that share phenotypes with IER5: view

Animal Model Products

miRNA for IER5 Gene

miRTarBase miRNAs that target IER5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER5 Gene

Localization for IER5 Gene

Subcellular locations from

Jensen Localization Image for IER5 Gene COMPARTMENTS Subcellular localization image for IER5 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5 Gene

Pathways & Interactions for IER5 Gene

SuperPathways for IER5 Gene

No Data Available

Interacting Proteins for IER5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000356549 Q5VY09-IER5_HUMAN for IER5 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for IER5 Gene


No data available for Pathways by source and SIGNOR curated interactions for IER5 Gene

Drugs & Compounds for IER5 Gene

No Compound Related Data Available

Transcripts for IER5 Gene

mRNA/cDNA for IER5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5 Gene

Immediate early response 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IER5 Gene

No ASD Table

Relevant External Links for IER5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IER5 Gene

mRNA expression in normal human tissues for IER5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5 Gene

This gene is overexpressed in Placenta (42.4) and Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IER5 Gene

SOURCE GeneReport for Unigene cluster for IER5 Gene Hs.15725

genes like me logo Genes that share expression patterns with IER5: view

Protein tissue co-expression partners for IER5 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IER5 Gene

Orthologs for IER5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IER5 35
  • 85.51 (n)
  • 77.95 (a)
IER5 36
  • 75 (a)
(Mus musculus)
Mammalia Ier5 35
  • 81.47 (n)
  • 77.3 (a)
Ier5 16
Ier5 36
  • 77 (a)
(Pan troglodytes)
Mammalia IER5 35
  • 98.67 (n)
  • 99.38 (a)
IER5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ier5 35
  • 80.15 (n)
  • 75.33 (a)
(Canis familiaris)
Mammalia IER5 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia IER5 36
  • 54 (a)
(Gallus gallus)
Aves IER5 35
  • 64.14 (n)
  • 59.6 (a)
IER5 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7086 35
(Danio rerio)
Actinopterygii ier5 35
  • 48.87 (n)
  • 43.61 (a)
wufb04b03 35
ier5 36
  • 39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9060 35
Species with no ortholog for IER5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5 Gene

Gene Tree for IER5 (if available)
Gene Tree for IER5 (if available)

Paralogs for IER5 Gene

Paralogs for IER5 Gene

genes like me logo Genes that share paralogs with IER5: view

Variants for IER5 Gene

Sequence variations from dbSNP and Humsavar for IER5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3747955 - 181,089,177(-) AGGCA(C/T)GAGCG reference, missense
rs3747954 - 181,089,404(-) AGATA(A/C/T)CTCGG reference, missense
rs1416829 - 181,089,482(+) CCCCC(C/G)GCGCT reference, missense
rs1361365 - 181,089,507(+) GCCGC(A/G)ACCAG reference, missense
rs3747951 - 181,089,755(-) CCCGG(A/G)GCTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IER5 Gene

Variant ID Type Subtype PubMed ID
esv22385 CNV Loss 19812545

Variation tolerance for IER5 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IER5 Gene

Disorders for IER5 Gene

Relevant External Links for IER5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IER5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5 Gene

Publications for IER5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Gene expression in the brain across the sleep-waking cycle. (PMID: 11102586) Cirelli C. … Tononi G. (Brain Res. 2000) 2 3
  3. Ier5, a novel member of the slow-kinetics immediate-early genes. (PMID: 10049588) Williams M. … Hunter K. (Genomics 1999) 2 3
  4. Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells. (PMID: 25355627) Ishikawa Y. … Sakurai H. (FEBS J. 2015) 3
  5. HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y. … Sakurai H. (FEBS Lett. 2015) 3

Products for IER5 Gene

Sources for IER5 Gene