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IER5 Gene

protein-coding GIFtS: 47

GC01P179324

immediate early response 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC102760 ^²
OTTHUMP00000033133 ^²
SBBI48 ^²

Descriptions
immediate early response 5 ^²

External Ids
HGNC: 5393¹
Entrez Gene: 51278²
UniProtKB: Q5VY09³
Ensembl: ENSG00000162783⁷

Search outside databases for aliases for IER5 gene

Previous GC identifers: GC01P178581 GC01P176486 GC01P177578 GC01P178297 GC01P177789

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IER5:

This gene encodes a protein that is similar to other immediate early response proteins. In the

mouse, a similar gene may play an important role in mediating the cellular response to mitogenic

signals. Studies in rats found the expression of a similar gene to be increased after waking and

sleep deprivation. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IER5 gene

Entrez Gene cytogenetic band: 1q25.3 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25.3

IER5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P179324: (about GC identifiers)

Start:	179,324,261 bp from pter
End:	179,326,602 bp from pter
Size:	2,342 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IER5_HUMAN, Q5VY09 (See protein sequence)

Recommended Name: Immediate early response gene 5 protein

Size: 327 amino acids; 33704 Da

Secondary accessions: B2RBV3 Q8WY68 Q9NY49 Q9NZP9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_057629.2

ENSEMBL proteins:

ENSP00000356549

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IER5)
	Human Recombinant Proteins from Abnova (IER5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for IER5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IER5), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IER5

Assays for IER5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5VY09

ProtoNet protein and cluster: Q5VY09

UniProtKB/Swiss-Prot: IER5_HUMAN, Q5VY09

Similarity: Belongs to the IER family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IER5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IER5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016545

Applied Biosystems Silencer® siRNAs for IER5

Sigma-Aldrich siRNA for IER5

Sigma-Aldrich shRNA for IER5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IER5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_016545
Myc/DDK tagged cDNA clone in CMV expression vector: NM_016545
untagged cDNA clone in CMV expression vector: NM_016545

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016545

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for IER5 (ENSP00000356549³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MPDZ	ENSP00000370410³	STRING (score=.872)
PDZK1IP1	ENSP00000360952³	STRING (score=.831)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IER5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IER5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IER5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016545

Sigma-Aldrich siRNA for IER5

Sigma-Aldrich shRNA for IER5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_016545

REFSEQ mRNAs for IER5 gene:

NM_016545.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_016545

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016545
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016545
                                 untagged cDNA clone in CMV expression vector: NM_016545

Additional cDNA sequence:

AF178984.1 AF258581.1 AJ251089.1 AK300732.1 AK314830.1 BC000128.2 BC108253.1 CR591624.1

CR611489.1 CR618453.1 CR622335.1

5 DOTS entries:

DT.415264 DT.100819509 DT.121348712 DT.100700272 DT.95372668

24/198 AceView cDNA sequences (see all 198 ):

AJ705658 CA430704 AA235294 BM709697 BC000128 AF178984 BG105920 CR591624

BE046403 AI439861 AI973016 BI793212 AW138404 BF001424 AW590823 CR611489

BF063820 AW087616 BQ222173 AI572505 NM_016545 AW006746 AI375277 BM843960

highest scoring ESTs for IER5:

AA521293 AA031986 AA031987 AA234849 AA235294 AA280979 AA330737 AA436461 AA436509 AA565380

Unigene Cluster for IER5:

Immediate early response 5

Hs.716489 [show with all ESTs]

Unigene Representative Sequence: NM_016545

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000367577

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IER5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IER5

¹ / ² / ³

3 probe-sets matching IER5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53907_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA521293	1.00	1.00	1.00	1
218611_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016545	0.60	1.00	0.82	1
218611_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IER5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCCCTGGA

SOURCE GeneReport for Unigene cluster: Hs.716489

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IER5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	IER5¹	--	immediate early response 5	85.82(n) 78.57(a)	523618 XM_601920.3 XP_601920.2
rat (Rattus norvegicus)	Ier5¹	--	immediate early response 5	87.07(n) 92.86(a)	498256 NM_001025137.1 NP_001020308.1
mouse (Mus musculus)	Ier5^{1, 5}	1 (81.50 cM)⁵	immediate early response 5^{1, 5}	83(n)¹ 78.95(a)¹	15939¹ NM_010500.1¹ NP_034630.1¹ AF079527⁵ AF079528⁵ (see all 18)
zebrafish (Danio rerio)	wufb04b03²	--	Transcribed sequence with moderate similarity to protein more	79.74(n)	57036369
African clawed frog (Xenopus laevis)	BU901308.1²	--	--	80.31(n)	BU901308.1

About this table Species with no ortholog for IER5

ENSEMBL Gene Tree for IER5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IER5 gene

IER5L² IER2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/22 NCBI SNPs in IER5 are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6425663^1,2	A,C,F,H	179324497(+)	`CTTGTG/TTGGAG`	1	--	ut5¹		4		EU EA WA	412
	rs6662507^1,2	A,C,F,H	179322783(+)	`ccagaG/Agccat`	1	--	ng5¹		4		EU EA WA	412
	rs4652560^1,2	A,C,F,H	179323811(+)	`CTTGAT/AAAGAA`	1	--	ng5¹		6		EU EA WA NA	598
--	rs1416829^1,2	A,C,F	179325241(+)	`CCCCCC/GGCGCT`	1	R/G	mis¹ ese³		1		MN	184
	rs3747955^1,2	A,C	179324936(-)	`AGGCAC/TGAGCG`	1	R/H	mis¹ ese³		0	--	--	--	--
	rs10910866^1,2	F,H	179323900(+)	`ACTCTA/CGCGGG`	1	--	ng5¹		4		EU EA WA	420
	rs12058172^1,2	H	179323232(+)	`ATTCAG/AATTGT`	1	--	ng5¹		4		EU EA WA	412
--	rs1361365^1,2	C	179325266(+)	`GCCGCA/GACCAG`	1	Q/R	mis¹ ese³		3		EA NA	60
	rs3747954^1,2	F	179325163(-)	`AGATAC/TCTCGG`	1	V/I	mis¹ ese³		1		EA	1038
	rs3747951^1,2	H	179325514(-)	`CCCGGG/AGCTTT`	1	S/P	mis¹ ese³		3		EU EA	298

About this table

HapMap Linkage Disequilibrium images for IER5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607177

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for IER5 gene:

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
Gene expression in the brain across the sleep-waking cycle. (PubMed id 11102586)^{2, 3} Cirelli C. and Tononi G. (2000)
Ier5, a novel member of the slow-kinetics immediate-early genes. (PubMed id 10049588)^{2, 3} Williams M....Hunter K. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)³ Hillier L.D....Marra M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51278	HGNC: 5393	AceView: IER5	Ensembl:ENSG00000162783	euGenes: HUgn51278
ECgene: IER5	H-InvDB: IER5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IER5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IER5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IER5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IER5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IER5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IER5)
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	Chimera RNAi (IER5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for IER5

Search Tocris compounds for IER5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IER5

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IER5 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for IER5

Summaries
for IER5

Genomic Location
for IER5

Proteins
for IER5

Protein Domains/
Families
for IER5

Gene Function
for IER5

Pathways & Interactions
for IER5

Drugs & Compounds
for IER5

Transcripts
for IER5

Expression
for IER5

Orthologs
for IER5

Paralogs
for IER5

SNPs/Variants
for IER5

Disorders & Mutations
for IER5

Medical News
for IER5

Publications
for IER5

Search for IER5

Genome Databases showing IER5

Other Databases showing IER5

Specialized Databases showing IER5

Licensable Technologies
for IER5

Services
for IER5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IER5 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor IER5

Summariesfor IER5

Genomic Locationfor IER5

Proteinsfor IER5

Protein Domains/Familiesfor IER5

Gene Functionfor IER5

Pathways & Interactionsfor IER5

Drugs & Compoundsfor IER5

Transcriptsfor IER5

Expression for IER5

Orthologsfor IER5

Paralogsfor IER5

SNPs/Variantsfor IER5

Disorders & Mutationsfor IER5

Medical Newsfor IER5

Publicationsfor IER5

Search for IER5

Genome Databases showing IER5

Other Databases showing IER5

Specialized Databases showing IER5

Licensable Technologiesfor IER5

Servicesfor IER5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IER5

Summaries
for IER5

Genomic Location
for IER5

Proteins
for IER5

Protein Domains/
Families
for IER5

Gene Function
for IER5

Pathways & Interactions
for IER5

Drugs & Compounds
for IER5

Transcripts
for IER5

Expression
for IER5

Orthologs
for IER5

Paralogs
for IER5

SNPs/Variants
for IER5

Disorders & Mutations
for IER5

Medical News
for IER5

Publications
for IER5

Licensable Technologies
for IER5

Services
for IER5