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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IER5 Gene

protein-coding GIFtS: 46
GCID: GC01P181057

immediate early response 5

Explore 3 diseases affiliated with
IER5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immediate Early Response 5¹ ²
SBBI48²
Immediate Early Response Gene 5 Protein²

External Ids:	HGNC: 5393¹	Entrez Gene: 51278²	Ensembl: ENSG00000162783⁷	OMIM: 607177⁵	UniProtKB: Q5VY09³

Export aliases for IER5 gene to outside databases

Previous GC identifers: GC01P178581 GC01P176486 GC01P177578 GC01P178297 GC01P177789 GC01P179324 GC01P152288

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IER5:

This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene

may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the

expression of a similar gene to be increased after waking and sleep deprivation. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IER5 gene promoter:
STAT1 STAT1beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 NF-kappaB STAT1alpha GATA-1 STAT3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IER5 promoter sequence

Search SABiosciences Chromatin IP Primers for IER5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IER5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25.3

IER5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P181057: view genomic region (about GC identifiers)

Start:	181,057,638 bp from pter	End:	181,059,979 bp from pter
Size:	2,342 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IER5_HUMAN, Q5VY09 (See protein sequence)

Recommended Name: Immediate early response gene 5 protein

Size: 327 amino acids; 33704 Da

Secondary accessions: B2RBV3 Q8WY68 Q9NY49 Q9NZP9

Explore the universe of human proteins at neXtProt for IER5: NX_Q5VY09

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VY09

IER5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057629.2

ENSEMBL proteins:

ENSP00000356549

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IER5 for domains About GeneDecksing

1 InterPro domain/family:

IPR008653 IER

Graphical View of Domain Structure for InterPro Entry Q5VY09

ProtoNet protein and cluster: Q5VY09

UniProtKB/Swiss-Prot: IER5_HUMAN, Q5VY09

Similarity: Belongs to the IER family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IER5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IER5 (Q5VY09³ ENSP00000356549⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2R2B	Q00005³, ENSP00000336591⁴	I2D: score=2 STRING: ENSP00000336591

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IER5
Search CenterWatch for drugs/clinical trials and news about IER5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IER5 gene:

NM_016545.4

Unigene Cluster for IER5:

Immediate early response 5

Hs.730689 [show with all ESTs]

Unigene Representative Sequence: NM_016545

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367577(uc001got.4)

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Additional cDNA sequence:

AF178984.1 AF258581.1 AJ251089.1 AK300732.1 AK314830.1 BC000128.2 BC108253.1

5 DOTS entries:

DT.415264 DT.100819509 DT.121348712 DT.100700272 DT.95372668

24/198 AceView cDNA sequences (see all 198):

AI913021 BE018207 BQ222173 BX360769 R92316 AW087616 W01100 CA430704

BM843960 BG105920 AJ705658 AA599690 BU678407 AA235294 BF001424 BF447270

AI439861 BC000128 AW006746 CN482606 AA436461 AI097594 BM846220 BF063820

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IER5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCCCTGGA

About this image

IER5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

nGnG Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IER5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IER5

SOURCE GeneReport for Unigene cluster: Hs.730689

SABiosciences Custom PCR Arrays for IER5

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IER5 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IER5⁶	Uncharacterized protein	64(a)	1 ↔ 1	8(6111170-6111439)
African clawed frog (Xenopus laevis)	Amphibia	BU901308.1²	--	80.31(n)		BU901308.1
zebrafish (Danio rerio)	Actinopterygii	wufb04b03²	Transcribed sequence with moderate similarity to protein more	79.74(n)		57036369

ENSEMBL Gene Tree for IER5 (if available)
TreeFam Gene Tree for IER5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IER5 gene

IER5L² IER2²

1 SIMAP similar gene for IER5 using alignment to 2 protein entries: IER5_HUMAN (see all proteins):

IER2

IER5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189927073^1,2		--	181055678(+)	`GAGAAC/TTAGCC`	1	--	us2k¹		0	--	--	--	--
rs182425123^1,2		--	181056047(+)	`TGATCC/TGCCCA`	1	--	us2k¹		0	--	--	--	--
rs140126042^1,2		--	181056048(+)	`GATCCA/GCCCAC`	1	--	us2k¹		0	--	--	--	--
rs186717944^1,2		--	181056103(+)	`CCCGGC/TTGATT`	1	--	us2k¹		0	--	--	--	--
rs6662507^1,2	C,F,A,H,	--	181056160(+)	`CCAGAG/AGCCAT`	1	--	us2k¹		23		NS EA NA WA CSA	2352
rs202050728^1,2		--	181056508(+)	`TGGTA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs12058172^1,2	C,F,H	--	181056609(+)	`ATTCAG/AATTGT`	1	--	us2k¹		8		NS EA NA	696
rs142195399^1,2		--	181056637(+)	`TTATCA/GTCTGT`	1	--	us2k¹		0	--	--	--	--
rs145955698^1,2		--	181056781(+)	`ATGTTC/TCCAGT`	1	--	us2k¹		0	--	--	--	--
rs116654479^1,2		--	181057067(+)	`GAACCT/CGTAAC`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for IER5 (181057638 - 181059979 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IER5
1 CNV: 65346

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IER5 for disorders           About GeneDecksing

OMIM gene information: 607177    OMIM disorders: --

3 diseases for IER5:    About MalaCards

stem cell leukemia t-cell leukemia leukemia

1 disease from the University of Copenhagen DISEASES database for IER5:

Stem cell leukemia

Export disorders for IER5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IER5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with IER5)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
Gene expression in the brain across the sleep-waking cycle. (PubMed id 11102586)^{1, 3} Cirelli C. and Tononi G. (2000)
Ier5, a novel member of the slow-kinetics immediate-early genes. (PubMed id 10049588)^{1, 3} Williams M....Hunter K. (1999)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute m yeloid leukemia. (PubMed id 22132193)¹ Nakamura S....Yamashita M. (2011)
Induced expression of the IER5 gene by gamma-ray irra diation and its involvement in cell cycle checkpoint control and survival. (PubMed id 19238419)¹ Ding K.K....Zhou P.K. (2009)
An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)¹ Glatter T....Gstaiger M. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51278	HGNC: 5393	AceView: IER5	Ensembl:ENSG00000162783	euGenes: HUgn51278
ECgene: IER5	H-InvDB: IER5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IER5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IER5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IER5 gene:
Search GeneIP for patents involving IER5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ThermoFisher Antibodies for IER5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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IER5 Gene

immediate early response 5

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Export list of displayed genes

IER5 Gene

immediate early response 5

Aliasesfor IER5 gene

Summariesfor IER5 gene

Genomic Viewsfor IER5 gene

Proteinsfor IER5 gene

Protein Domains /Familiesfor IER5 gene

Functionfor IER5 gene

Pathways & Interactionsfor IER5 gene

Drugs & Compoundsfor IER5 gene

Transcriptsfor IER5 gene

Expression for IER5 gene

Orthologsfor IER5 gene

Paralogsfor IER5 gene

Genomic Variantsfor IER5 gene

Disorders / Diseasesfor IER5 gene

Publicationsfor IER5 gene

External Searches for IER5 gene

Genome Databases showing IER5 gene

Other Databases showing IER5 gene

Specialized Databases showing IER5 gene

Intellectual Propertyfor IER5 gene

Productsfor IER5 gene

View Random Gene

Aliases
for IER5 gene

Summaries
for IER5 gene

Genomic Views
for IER5 gene

Proteins
for IER5 gene

Protein Domains /
Families
for IER5 gene

Function
for IER5 gene

Pathways & Interactions
for IER5 gene

Drugs & Compounds
for IER5 gene

Transcripts
for IER5 gene

Expression
for IER5 gene

Orthologs
for IER5 gene

Paralogs
for IER5 gene

Genomic Variants
for IER5 gene

Disorders / Diseases
for IER5 gene

Publications
for IER5 gene

Intellectual Property
for IER5 gene

Products
for IER5 gene