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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IER3 Gene

protein-coding   GIFtS: 55
GCID: GC06M030766

immediate early response 3
 Explore 35 diseases affiliated with
IER3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IER3    

Aliases
for IER3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immediate Early Response 31 2     Protein DIF-22 3
PRG11 2 3 5     PACAP-Responsive Gene 1 Protein2 3
DIF22 3 5     GLY962 5
IEX12 3 5     Anti-Death Protein2
DIF-21 2     Expressed In Pancreatic Carcinoma2
IEX-11 2     Gly96, Mouse, Homolog Of2
IEX-1L1 2     Immediately Early Gene X-12
Differentiation-Dependent Gene 2 Protein2 3     Radiation-Inducible Immediate-Early Gene IEX-12
Immediate Early Protein GLY962 3     Protein PRG13
Immediate Early Response 3 Protein2 3     

External Ids:    HGNC: 53921   Entrez Gene: 88702   Ensembl: ENSG000001373317   OMIM: 6029965   UniProtKB: P466953   

Export aliases for IER3 gene to outside databases

Previous GC identifers: GC06M030481 GC06M030817 GC06M030818


Summaries
for IER3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IER3:
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis.
Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not
found in vivo and do not generate a valid protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695
Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase
PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the
NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell
stress, such as starvation or gemcitabine treatment

Gene Wiki entry for IER3


Genomic Views
for IER3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IER3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IER3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

IER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030766:  view genomic region     (about GC identifiers)

Start:
 30,710,976 bp from pter      End:
 30,712,331 bp from pter
Size:
 1,356 bases      Orientation:
 minus strand

5 alternative locations:
Chr6-,ALT_REF_LOCI_2 30,700,841-30,741,380      Chr6-,ALT_REF_LOCI_3 30,701,238-30,713,627      Chr6-,ALT_REF_LOCI_6 30,700,508-30,737,440     
Chr6-,ALT_REF_LOCI_4 30,678,729-30,680,080      Chr6-,ALT_REF_LOCI_7 30,632,758-30,634,109     

Proteins
for IER3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695 (See protein sequence)
Recommended Name: Radiation-inducible immediate-early gene IEX-1  
Size: 156 amino acids; 16903 Da
Subunit: Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: Q5SU30 Q92691 Q93044

Explore the universe of human proteins at neXtProt for IER3: NX_P46695

Post-translational modifications:

  • Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2
    • and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli1
  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46695

    • IER3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003888.2  
    ENSEMBL proteins: 
     ENSP00000259874   ENSP00000365557  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IER3
    OriGene Custom Protein Services for IER3 
    GenScript Custom Purified and Recombinant Proteins Services for IER3
    Novus Biologicals IER3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IER3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016021integral to membrane IEA--


    IER3 for ontologies           About GeneDecksing



    IER3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IER3 Antibodies
    Search for Antibodies for IER3 at Abcam  
    Uscn Antibodies for IER3
    ThermoFisher Antibodies for IER3

    Assay Products for IER3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IER3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IER3

    Protein Domains /
    Families
    for IER3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IER3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024829 IEX-1

    Graphical View of Domain Structure for InterPro Entry P46695

    ProtoNet protein and cluster: P46695

    UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695
    Similarity: Belongs to the IER3 family


    Function
    for IER3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695
    Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase
    PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the
    NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell
    stress, such as starvation or gemcitabine treatment
    Induction: By radiation, 12-O-tetradecanoyl phorbol-13 acetate (TPA), okadaic acid, TNF and NUPR1

         Genatlas biochemistry entry for IER3:
    immediate early gene induced by ionizing radiation and activators of PRKC,including a shorter (IEX-S) and a larger non
    spliced isoform (IEX-L) the later inhibiting apoptosis involved in NFKB mediate survival cell

    miRNA
    Products:            		miRTarBase miRNAs that target IER3:
    hsa-mir-197 (MIRT004200)

    OriGene 3'-UTR Clone: IER3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IER3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate IER3:
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-142-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-589* hsa-miR-4255 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: IER3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IER3 (see all 7)
    OriGene shRNA RFP: IER3
    OriGene siRNA: IER3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IER3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IER3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IER3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IER3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IER3 (NM_003897)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IER3
    Search LifeMap BioReagents cell lines for IER3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15451437


    IER3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IER3:
     Increased G1 DNA content  Increased resistance to MDM2 i 

    Animal Models:
         Mouse knock-out Ier3tm1Raku for IER3
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ier3):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  muscle 

    IER3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IER3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for IER3 (P466951, 2, 3 ENSP000002598744) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R5BQ151732, 3MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    PPP2CAP677752, 3MINT-2835686 MINT-2835661 I2D: score=1 
    PPP2R5CQ133622, 3MINT-2835469 MINT-2835420 I2D: score=1 
    MAPK1P284822, 3MINT-2835582 I2D: score=4 
    CAMLGP490691, 3, ENSP000002971564EBI-1748945,EBI-1748958 I2D: score=2 STRING: ENSP00000297156
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0003085negative regulation of systemic arterial blood pressure IEA--
    GO:0006915apoptotic process TAS9196025
    GO:0009653anatomical structure morphogenesis TAS9196025
    GO:0042981regulation of apoptotic process ----


    IER3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IER3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IER3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IER3
    4 Novoseek chemical compound relationships for IER3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 20.2 2 9791001 (1), 12899517 (1)
    cycloheximide 10.7 2 17107344 (1)
    etoposide 9.13 1 17107344 (1)
    estrogen 0 2 15120418 (1), 19951611 (1)

    Search CenterWatch for drugs/clinical trials and news about IER3 / IEX1 

    Transcripts
    for IER3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IER3 gene (2 alternative transcripts): 
    NM_003897.3  NM_052815.1  

    Unigene Cluster for IER3:

    Immediate early response 3
    Hs.76095  [show with all ESTs]
    Unigene Representative Sequence: BM906591
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259874(uc003nrn.3) ENST00000376377

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IER3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IER3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate IER3:
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-142-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-589* hsa-miR-4255 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: IER3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IER3 (see all 7)
    OriGene shRNA RFP: IER3
    OriGene siRNA: IER3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IER3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IER3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IER3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IER3 (NM_003897)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IER3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IER3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IER3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IER3

    Additional cDNA sequence: 

    AF039067.1 AF083421.1 AJ227914.1 AK222588.1 AK314162.1 BC000844.2 BC005080.1 BT006703.1 
    S81914.1 Y14551.1 

    19 DOTS entries:

    DT.418090  DT.100839835  DT.92326984  DT.100839846  DT.40116205  DT.100834870  DT.102824035  DT.100839845 
    DT.121370704  DT.100838072  DT.121370890  DT.92443683  DT.97791426  DT.97855230  DT.99986295  DT.100839839 
    DT.100839842  DT.121370878  DT.91638085 

    21 AceView cDNA sequences:

    CR625889 CR599601 BC000844 CR605389 BC005080 CR594999 CR613281 CR594838 
    CR599121 Y14551 AF039067 S81914 BT006703 NM_052815 BV177387 NM_003897 
    AF083421 AJ227914 CD617661 BG946513 BG946500 

    GeneLoc Exon Structure


    Expression
    for IER3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCATCCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IER3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    OvaryAntral FollicleCumulus CellsOvary
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See IER3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IER3

    SOURCE GeneReport for Unigene cluster: Hs.76095
        SABiosciences Expression via Pathway-Focused PCR Arrays including IER3: 
              Hypoxia Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IER3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IER3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IER3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IER3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER3

    Orthologs
    for IER3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IER3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ier31 , 5 immediate early response 31, 5 78.35(n)1
    75.32(a)1    		   17 (18.70 cM)5
    159371  NM_133662.21  NP_598423.11 
     358216845 
    lizard
    (Anolis carolinensis)    		 Reptilia IER36
    		 --
    		 43(a)
    		 1 ↔ 1
    		 GL343623.1(76403-79596)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1583436
    		 zgc:158343
    		 23(a)
    		 1 ↔ 1
    		 5(10606824-10607450)


    ENSEMBL Gene Tree for IER3 (if available)
    TreeFam Gene Tree for IER3 (if available) 

    Paralogs
    for IER3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IER3 gene
    2 SIMAP similar genes for IER3 using alignment to 2 protein entries:     IEX1_HUMAN (see all proteins):
    PRG1    IEX-1L

    IER3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IER3
    PGOHUM00000245755


    Genomic Variants
    for IER3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 NCBI SNPs in IER3 are shown (see all 57)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1852281071,2
    		--30710513(+) GCCTCC/GGCCCA 2 -- us2k1 ds50010--------
    rs1420213971,2
    		--30710569(+) CAGCCA/CGCCCG 2 -- us2k1 ds50010--------
    rs1149650761,2
    		F,--30710632(+) CATCCC/TTGCCG 2 -- ds5001 us2k12Minor allele frequency- T:0.11WA EA 238
    rs1901235041,2
    		--30710912(+) CCGCCG/TGTCCT 2 -- us2k1 ds50010--------
    rs1812014081,2
    		--30710963(+) CAAAGA/GTACAC 2 -- ds5001 us2k10--------
    rs1124385211,2
    		C--30710979(+) ACTGCT/AGACAG 2 -- ut31 us2k11Minor allele frequency- A:0.00CSA 1
    rs10499431,2
    		C,F,A,--30711026(-) GTCGAG/CATCGC 2 -- ut31 us2k14Minor allele frequency- C:0.06MN WA NA EA 542
    rs177191,2
    		C,F,A,H,--30711031(+) CTCGAC/TAGTCG 2 -- ut31 us2k1 ese316Minor allele frequency- T:0.07MN NS EA WA NA 2520
    rs10499421,2
    		--30711067(-) AGGTAG/AAGGGT 2 -- us2k1 ut31 ese31Minor allele frequency- A:0.00MN 184
    rs1144456231,2
    		--30711109(+) TGGAAG/AGATCT 2 -- ut31 us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for IER3 (30710976 - 30712331 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IER3
         1 CNV: 3600

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    Disorders / Diseases
    for IER3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IER3 for disorders           About GeneDecksing

    OMIM gene information: 602996    OMIM disorders: --

    20/35 diseases for IER3 (see all 35):    About MalaCards
    gilles de la tourette syndrome    juvenile hyaline fibromatosis    pancreatic carcinoma    obsessive-compulsive disorder
    hyalinosis    pancreatitis    tourette syndrome    carcinoma
    fibromatosis    systemic lupus erythematosus    lupus erythematosus    kallmann syndrome
    acute lymphoblastic leukemia    lymphoblastic leukemia    herpes simplex    dyslexia
    neuroendocrine tumor    multiple myeloma    myelodysplastic syndrome    measles

    6 Novoseek disease relationships for IER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 17.2 22 11844788 (2), 17704804 (2), 18026799 (2), 8603392 (2) (see all 11)
    necrosis 9.24 8 8603392 (2), 9791001 (1), 16528364 (1), 17538120 (1) (see all 6)
    breast cancer 0 2 15102447 (1), 15120418 (1)
    prostate cancer 0 1 14656475 (1)
    cancer 0 4 15087407 (2), 19951611 (1)
    hyperplasia 0 1 15451437 (1)

    Human Genome Epidemiology (HuGE) Navigator: IER3 (4 documents)

    Export disorders for IER3 gene to outside databases

    Publications
    for IER3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IER3 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with IER3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a radiation-inducible glycosylated human early-response gene. (PubMed id 8603392)1, 2, 3, 9 Kondratyev A.D.... Jung M.O. (1996)
    2. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PubMed id 12356731)1, 2, 9 Garcia J....Porteu F. (2002)
    3. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PubMed id 16456541)1, 2, 9 Letourneux C....Porteu F. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. (PubMed id 9703517)1, 3 Wu M.X....Schlossman S.F. (1998)
    6. Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. (PubMed id 9196025)1, 2 Pietzsch A.... Schmitz G. (1997)
    7. PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. (PubMed id 8653710)1, 2 Schaefer H.... Schmidt W.E. (1996)
    8. Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer. (PubMed id 18026799)1, 9 Sasada T....Takabayashi A. (2008)
    9. Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells. (PubMed id 15855159)1, 9 Kruse M.L....Schafer H. (2005)
    10. Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3. (PubMed id 9791001)1, 9 Kobayashi T....Kumar R. (1998)

    External Searches for IER3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IER3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8870 HGNC: 5392 AceView: IER3 Ensembl:ENSG00000137331 euGenes: HUgn8870
    ECgene: IER3 H-InvDB: IER3

    Other Databases showing IER3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IER3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IER3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IER3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IER3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IER3 gene:
    Search GeneIP for patents involving IER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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