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Aliases for IER3 Gene

Aliases for IER3 Gene

  • Immediate Early Response 3 2 3 5
  • Differentiation-Dependent Gene 2 Protein 3 4
  • Immediate Early Response 3 Protein 3 4
  • PACAP-Responsive Gene 1 Protein 3 4
  • Immediate Early Protein GLY96 3 4
  • Protein DIF-2 3 4
  • DIF2 3 4
  • IEX1 3 4
  • PRG1 3 4
  • Radiation-Inducible Immediate-Early Gene IEX-1 3
  • Expressed In Pancreatic Carcinoma 3
  • Immediately Early Gene X-1 3
  • Gly96, Mouse, Homolog Of 3
  • Anti-Death Protein 3
  • Protein PRG1 4
  • IEX-1L 3
  • DIF-2 3
  • GLY96 3
  • IEX-1 3

External Ids for IER3 Gene

Previous GeneCards Identifiers for IER3 Gene

  • GC06M030766
  • GC06M030481
  • GC06M030817
  • GC06M030818

Summaries for IER3 Gene

Entrez Gene Summary for IER3 Gene

  • This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for IER3 Gene

IER3 (Immediate Early Response 3) is a Protein Coding gene. Diseases associated with IER3 include Kallmann Syndrome. Among its related pathways are Innate Immune System and GAB1 signalosome.

UniProtKB/Swiss-Prot for IER3 Gene

  • May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Gene Wiki entry for IER3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER3 Gene

Genomics for IER3 Gene

Regulatory Elements for IER3 Gene

Enhancers for IER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G030816 2 FANTOM5 Ensembl ENCODE dbSUPER 63.2 -75.4 -75367 6.6 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SLC30A9 ZNF143 FOS KLF13 IER3 DDR1 HLA-E PPP1R18 LINC00243 FLOT1 HCG18 VARS2 DDR1-AS1 PRR3
GH06G030777 2.1 FANTOM5 Ensembl ENCODE dbSUPER 56.8 -37.8 -37812 10.1 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC IER3 PPP1R10 PAIP1P1 VARS2 LY6G5B GTF2H4 DHX16 NFKBIL1 DDR1 ETF1P1
GH06G030757 2.1 FANTOM5 Ensembl ENCODE dbSUPER 53.7 -19.8 -19765 14.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 IER3 VARS2 DDR1 C6orf136 PPP1R18 FLOT1 HCG18 LINC00243 PRR3 TUBB
GH06G030746 2.1 FANTOM5 Ensembl ENCODE dbSUPER 50.8 -6.9 -6874 9.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 IER3 DHX16 LY6G5B GTF2H4 DDX39B PPP1R10 PAIP1P1 ABCF1 HLA-K VARS2
GH06G030787 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32 -44.1 -44098 1.7 ELF3 TBP ARID4B RARA ZNF121 CREM MIXL1 THAP11 SMARCA5 SP5 IER3 VARS2 FLOT1 DDR1 DDR1-AS1 HLA-L GTF2H4 DPCR1 HCG20 HCG21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IER3 on UCSC Golden Path with GeneCards custom track

Promoters for IER3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195435 1254 2601 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Transcription factor binding sites by QIAGEN in the IER3 gene promoter:

Genomic Location for IER3 Gene

Chromosome:
6
Start:
30,743,199 bp from pter
End:
30,744,554 bp from pter
Size:
1,356 bases
Orientation:
Minus strand

Genomic View for IER3 Gene

Genes around IER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for IER3 Gene

  • Protein details for IER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46695-IEX1_HUMAN
    Recommended name:
    Radiation-inducible immediate-early gene IEX-1
    Protein Accession:
    P46695
    Secondary Accessions:
    • Q5SU30
    • Q92691
    • Q93044

    Protein attributes for IER3 Gene

    Size:
    156 amino acids
    Molecular mass:
    16903 Da
    Quaternary structure:
    • Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.

neXtProt entry for IER3 Gene

Post-translational modifications for IER3 Gene

  • Glycosylated.
  • Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli.
  • Glycosylation at posLast=133133
  • Modification sites at PhosphoSitePlus

Other Protein References for IER3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IER3

No data available for DME Specific Peptides for IER3 Gene

Domains & Families for IER3 Gene

Protein Domains for IER3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P46695

UniProtKB/Swiss-Prot:

IEX1_HUMAN :
  • Belongs to the IER3 family.
Family:
  • Belongs to the IER3 family.
genes like me logo Genes that share domains with IER3: view

No data available for Gene Families for IER3 Gene

Function for IER3 Gene

Molecular function for IER3 Gene

GENATLAS Biochemistry:
immediate early gene induced by ionizing radiation and activators of PRKC,including a shorter (IEX-S) and a larger non spliced isoform (IEX-L) the later inhibiting apoptosis involved in NFKB mediate survival cell
UniProtKB/Swiss-Prot Function:
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
UniProtKB/Swiss-Prot Induction:
By radiation, 12-O-tetradecanoyl phorbol-13 acetate (TPA), okadaic acid, TNF and NUPR1.

Gene Ontology (GO) - Molecular Function for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15451437
genes like me logo Genes that share ontologies with IER3: view
genes like me logo Genes that share phenotypes with IER3: view

Animal Models for IER3 Gene

MGI Knock Outs for IER3:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IER3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IER3 Gene

Localization for IER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IER3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20467439
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IER3: view

Pathways & Interactions for IER3 Gene

genes like me logo Genes that share pathways with IER3: view

SIGNOR curated interactions for IER3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 9196025
GO:0009653 anatomical structure morphogenesis TAS 9196025
GO:0010941 regulation of cell death IBA --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0043066 negative regulation of apoptotic process TAS,IEA --
genes like me logo Genes that share ontologies with IER3: view

Drugs & Compounds for IER3 Gene

(3) Drugs for IER3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IER3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IER3: view

Transcripts for IER3 Gene

mRNA/cDNA for IER3 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER3 Gene

Immediate early response 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IER3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER3 Gene

No ASD Table

Relevant External Links for IER3 Gene

GeneLoc Exon Structure for
IER3
ECgene alternative splicing isoforms for
IER3

Expression for IER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IER3 Gene:

IER3

SOURCE GeneReport for Unigene cluster for IER3 Gene:

Hs.76095

Evidence on tissue expression from TISSUES for IER3 Gene

  • Skin(4.4)
  • Intestine(2.8)
  • Lung(2.4)
  • Heart(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with IER3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER3 Gene

Orthologs for IER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IER3 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia IER3 34 35
  • 85.9 (n)
dog
(Canis familiaris)
Mammalia IER3 34 35
  • 83.97 (n)
rat
(Rattus norvegicus)
Mammalia Ier3 34
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Ier3 34 16 35
  • 78.14 (n)
oppossum
(Monodelphis domestica)
Mammalia IER3 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IER3 35
  • 41 (a)
OneToOne
Species where no ortholog for IER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IER3 Gene

ENSEMBL:
Gene Tree for IER3 (if available)
TreeFam:
Gene Tree for IER3 (if available)

Paralogs for IER3 Gene

(2) SIMAP similar genes for IER3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IER3 Gene

genes like me logo Genes that share paralogs with IER3: view

No data available for Paralogs for IER3 Gene

Variants for IER3 Gene

Sequence variations from dbSNP and Humsavar for IER3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000214172 -- 30,743,854(+) GTTGG(A/G)GATAC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000824290 -- 30,745,453(+) CACAC(A/G)TGAAG intron-variant, upstream-variant-2KB
rs1001100498 -- 30,743,309(+) CCCTA(A/G)AGGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001153712 -- 30,745,719(+) CAGTA(C/G)CTGGG intron-variant, upstream-variant-2KB
rs1001533409 -- 30,743,107(+) CGGGC(C/T)GGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IER3 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2759413 CNV loss 17122850
esv3411275 CNV duplication 20981092
esv3576135 CNV gain 25503493
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for IER3 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER3 Gene

Disorders for IER3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IER3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards
Search IER3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IER3

Genetic Association Database (GAD)
IER3
Human Genome Epidemiology (HuGE) Navigator
IER3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IER3
genes like me logo Genes that share disorders with IER3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IER3 Gene

Publications for IER3 Gene

  1. Identification and characterization of a radiation-inducible glycosylated human early-response gene. (PMID: 8603392) Kondratyev A.D. … Jung M.O. (Cancer Res. 1996) 2 3 4 22 64
  2. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PMID: 16456541) Letourneux C. … Porteu F. (EMBO J. 2006) 3 4 22 64
  3. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PMID: 12356731) Garcia J. … Porteu F. (EMBO J. 2002) 3 4 22 64
  4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64

Products for IER3 Gene

Sources for IER3 Gene

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