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IER3 Gene

protein-coding   GIFtS: 58
GCID: GC06M030766

Immediate Early Response 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immediate Early Response 31 2     DIF-22
DIF22 3 5     IEX-12
IEX12 3 5     IEX-1L2
PRG12 3 5     Anti-Death Protein2
Differentiation-Dependent Gene 2 Protein2 3     Expressed In Pancreatic Carcinoma2
Immediate Early Protein GLY962 3     Gly96, Mouse, Homolog Of2
Immediate Early Response 3 Protein2 3     Immediately Early Gene X-12
Protein DIF-22 3     Radiation-Inducible Immediate-Early Gene IEX-12
PACAP-Responsive Gene 1 Protein2 3     Protein PRG13
GLY962 5     

External Ids:    HGNC: 53921   Entrez Gene: 88702   Ensembl: ENSG000001373317   OMIM: 6029965   UniProtKB: P466953   

Export aliases for IER3 gene to outside databases

Previous GC identifers: GC06M030481 GC06M030817 GC06M030818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IER3 Gene:
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis.
Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are
not found in vivo and do not generate a valid protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for IER3 Gene:
IER3 (immediate early response 3) is a protein-coding gene. Diseases associated with IER3 include juvenile hyaline fibromatosis, and gilles de la tourette syndrome.

UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695
Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase
PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the
NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell
stress, such as starvation or gemcitabine treatment

Gene Wiki entry for IER3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IER3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER3 promoter sequence
   Search Chromatin IP Primers for IER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

IER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030766:  view genomic region     (about GC identifiers)

Start:
30,710,976 bp from pter      End:
30,712,331 bp from pter
Size:
1,356 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167246 2,059,070-2,060,421      Chr6-,NT_167248 2,003,905-2,005,256      Chr6-,NT_167249 2,043,293-2,044,644     
Chr6-,NT_113891.2 2,223,045-2,224,396      Chr6-,NT_167245 2,004,635-2,005,986     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695 (See protein sequence)
Recommended Name: Radiation-inducible immediate-early gene IEX-1  
Size: 156 amino acids; 16903 Da
Subunit: Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation
Secondary accessions: Q5SU30 Q92691 Q93044

Explore the universe of human proteins at neXtProt for IER3: NX_P46695

Explore proteomics data for IER3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by
    MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli1
  • Glycosylated1
  • Glycosylation2 at Asn133
  • Modification sites at PhosphoSitePlus

  • See IER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003888.2  
    ENSEMBL proteins: 
     ENSP00000365557   ENSP00000259874  

    IER3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IER3
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    Novus Biologicals IER3 Proteins
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IER3
    Cloud-Clone Corp. Proteins for IER3

    IER3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for IER3
    Cloud-Clone Corp. Antibodies for IER3
    ThermoFisher Antibodies for IER3
    LSBio Antibodies in human, mouse, rat for IER3

    IER3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IER3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IER3
    Cloud-Clone Corp. CLIAs for IER3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024829 IEX-1

    Graphical View of Domain Structure for InterPro Entry P46695

    ProtoNet protein and cluster: P46695

    UniProtKB/Swiss-Prot: IEX1_HUMAN, P46695
    Similarity: Belongs to the IER3 family


    IER3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IEX1_HUMAN, P46695
    Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase
    PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the
    NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell
    stress, such as starvation or gemcitabine treatment
    Induction: By radiation, 12-O-tetradecanoyl phorbol-13 acetate (TPA), okadaic acid, TNF and NUPR1

         Genatlas biochemistry entry for IER3:
    immediate early gene induced by ionizing radiation and activators of PRKC,including a shorter (IEX-S) and a larger
    non spliced isoform (IEX-L) the later inhibiting apoptosis involved in NFKB mediate survival cell

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15451437
         
    IER3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IER3:
     Increased G1 DNA content  Increased resistance to MDM2 i 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ier3):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     muscle  tumorigenesis 

    IER3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ier3tm1Raku for IER3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IER3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IER3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IER3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IER3:
    hsa-mir-98-5p (MIRT027607), hsa-mir-197-3p (MIRT004200)

    Block miRNA regulation of human, mouse, rat IER3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate IER3:
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-142-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-589* hsa-miR-4255 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidIER3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IER3
    Predesigned siRNA for gene silencing in human, mouse, rat IER3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IER3

    Clone
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    OriGene clones in human, mouse for IER3 (see all 6)
    OriGene ORF clones in mouse, rat for IER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IER3 (NM_003897)
    Sino Biological Human cDNA Clone for IER3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IER3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IER3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IEX1_HUMAN, P46695: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016021integral component of membrane IEA--

    IER3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including IER3: 
              Hypoxia Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for IER3 (P466951, 2, 3 ENSP000002598744) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R5BQ151731, 2, 3EBI-1748945,EBI-1369497 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    PPP2CAP677751, 2, 3EBI-1748945,EBI-712311 MINT-2835686 MINT-2835661 I2D: score=1 
    PPP2R5CQ133621, 2, 3EBI-1748945,EBI-1266156 MINT-2835469 MINT-2835420 I2D: score=1 
    MAPK1P284822, 3MINT-2835582 I2D: score=4 
    BAG6P463793I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint ----
    GO:0001562response to protozoan IEA--
    GO:0003085negative regulation of systemic arterial blood pressure IEA--
    GO:0006282regulation of DNA repair IEA--
    GO:0006915apoptotic process TAS9196025

    IER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IER3 (IEX1)

    4 Novoseek inferred chemical compound relationships for IER3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 20.2 2 9791001 (1), 12899517 (1)
    cycloheximide 10.7 2 17107344 (1)
    etoposide 9.13 1 17107344 (1)
    estrogen 0 2 15120418 (1), 19951611 (1)



    IER3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IER3 gene (2 alternative transcripts): 
    NM_003897.3  NM_052815.1  

    Unigene Cluster for IER3:

    Immediate early response 3
    Hs.76095  [show with all ESTs]
    Unigene Representative Sequence: BM906591
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376377 ENST00000259874(uc003nrn.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IER3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate IER3:
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-142-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-589* hsa-miR-4255 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidIER3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IER3
    Predesigned siRNA for gene silencing in human, mouse, rat IER3
    Clone
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    OriGene clones in human, mouse for IER3 (see all 6)
    OriGene ORF clones in mouse, rat for IER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IER3 (NM_003897)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER3
    Primer
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    OriGene qPCR primer pairs and template standards for IER3
    OriGene qSTAR qPCR primer pairs in human, mouse for IER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IER3
      QuantiTect SYBR Green Assays in human, mouse, rat IER3
      QuantiFast Probe-based Assays in human, mouse, rat IER3

    Additional mRNA sequence: 

    AF039067.1 AF083421.1 AK222588.1 AK314162.1 BC000844.2 BC005080.1 BT006703.1 S81914.1 
    Y14551.1 

    19 DOTS entries:

    DT.418090  DT.100839835  DT.100839846  DT.92326984  DT.40116205  DT.100834870  DT.102824035  DT.100839845 
    DT.121370704  DT.100838072  DT.97791426  DT.97855230  DT.99986295  DT.100839839  DT.100839842  DT.121370878 
    DT.121370890  DT.91638085  DT.92443683 

    21 AceView cDNA sequences:

    BC000844 CR613281 CR594999 CR625889 CR599601 CR605389 BC005080 CR599121 
    CR594838 AF039067 BV177387 Y14551 AF083421 NM_003897 NM_052815 S81914 
    BT006703 AJ227914 CD617661 BG946513 BG946500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATCCTGC
    IER3 Expression
    About this image


    IER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Endothelial Cells Corneal Endothelium
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
             Secondary follicles
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Mature Endothelial Cells Corneal Endothelium
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
    IER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IER3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76095
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IER3: 
              Hypoxia Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IER3
    OriGene qSTAR qPCR primer pairs in human, mouse for IER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IER3
    QuantiTect SYBR Green Assays in human, mouse, rat IER3
    QuantiFast Probe-based Assays in human, mouse, rat IER3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IER3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ier31 , 5 immediate early response 31, 5 78.14(n)1
    75.32(a)1
      17 (18.70 cM)5
    159371  NM_133662.21  NP_598423.11 
     358216845 
    lizard
    (Anolis carolinensis)
    Reptilia IER36
    immediate early response 3
    41(a)
    1 ↔ 1
    GL343623.1(76403-79596)


    ENSEMBL Gene Tree for IER3 (if available)
    TreeFam Gene Tree for IER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IER3 gene
    2 SIMAP similar genes for IER3 using alignment to 2 protein entries:     IEX1_HUMAN (see all proteins):
    PRG1    IEX-1L

    IER3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IER3
    PGOHUM00000245755


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IER3 (see all 34)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109470891,2
    C,F,H--30510395(+) TCCCTA/GCAAAA 1 -- ds50018Minor allele frequency- G:0.08NS EA WA NA EU 895
    rs1426497581,2
    C--30711447(+) TAAAT-/ATTA  
            
    ATTAG
    1 -- ut310--------
    rs94688221,2
    C,F,H--30712466(+) GGAGAC/TTTGAC 1 -- us2k115Minor allele frequency- T:0.05NS EA WA 2216
    rs1807697061,2
    --30712494(+) CCCAAC/GTGCAC 1 -- us2k10--------
    rs37573381,2
    C--30712768(+) gcacgC/Tgccac 1 -- us2k10--------
    rs117589871,2
    C,H--30712812(+) acgggA/Gtttca 1 -- us2k10--------
    rs1876268351,2
    --30712945(+) TGGTTC/TCCACT 1 -- us2k10--------
    rs742959031,2
    C,F--30713080(+) AATACT/CGACCC 1 -- us2k13Minor allele frequency- C:0.09WA NA EA 358
    rs1920201421,2
    --30713122(+) TATCCG/TTAGAA 1 -- us2k10--------
    rs1839443631,2
    --30713243(+) ACACAA/CCGCGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IER3 (30710976 - 30712331 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IER3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv830626CNV Loss17160897
    nsv884101CNV Gain21882294
    nsv884100CNV Gain21882294
    nsv884102CNV Gain21882294
    dgv1917e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IER3
    DNA2.0 Custom Variant and Variant Library Synthesis for IER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602996    OMIM disorders: --

    Selected diseases for IER3 (see all 36):    
    About MalaCards
    juvenile hyaline fibromatosis    gilles de la tourette syndrome    fibromatosis    dyslexia
    kallmann syndrome    obsessive-compulsive disorder    pancreatic ductal adenocarcinoma    measles
    pancreatitis    neuroendocrine tumor    herpes simplex    myelodysplastic syndromes
    multiple myeloma    systemic lupus erythematosus    age related macular degeneration    periodontitis
    myeloma    lymphoblastic leukemia    hypoxia    lupus erythematosus


    IER3 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for IER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 17.2 22 11844788 (2), 17704804 (2), 18026799 (2), 8603392 (2) (see all 11)
    necrosis 9.24 8 8603392 (2), 9791001 (1), 16528364 (1), 17538120 (1) (see all 6)
    breast cancer 0 2 15102447 (1), 15120418 (1)
    prostate cancer 0 1 14656475 (1)
    cancer 0 4 15087407 (2), 19951611 (1)
    hyperplasia 0 1 15451437 (1)

    Genetic Association Database (GAD): IER3
    Human Genome Epidemiology (HuGE) Navigator: IER3 (4 documents)

    Export disorders for IER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IER3 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with IER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a radiation-inducible glycosylated human early-response gene. (PubMed id 8603392)1, 2, 3, 9 Kondratyev A.D.... Jung M.O. (Cancer Res. 1996)
    2. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PubMed id 12356731)1, 2, 9 Garcia J.... Porteu F. (EMBO J. 2002)
    3. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PubMed id 16456541)1, 2, 9 Letourneux C.... Porteu F. (EMBO J. 2006)
    4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    5. TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility. (PubMed id 19837266)1, 4 Do T.N....Dorak M.T. (Cancer Genet. Cytogenet. 2009)
    6. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. (PubMed id 9703517)1, 3 Wu M.X.... Schlossman S.F. (Science 1998)
    9. Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. (PubMed id 9196025)1, 2 Pietzsch A.... Schmitz G. (Biochem. Biophys. Res. Commun. 1997)
    10. PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. (PubMed id 8653710)1, 2 Schaefer H.... Schmidt W.E. (Cancer Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8870 HGNC: 5392 AceView: IER3 Ensembl:ENSG00000137331 euGenes: HUgn8870
    ECgene: IER3 H-InvDB: IER3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IER3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IER3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IER3 gene:
    Search GeneIP for patents involving IER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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