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Aliases for IER2 Gene

Aliases for IER2 Gene

  • Immediate Early Response 2 2 3 5
  • ETR101 3 4
  • Immediate Early Response Gene 2 Protein 3
  • ChxI Protein Homolog 3
  • Protein ETR101 4
  • PIP92 4

External Ids for IER2 Gene

Previous GeneCards Identifiers for IER2 Gene

  • GC19P013124
  • GC19P013122
  • GC19P013261
  • GC19P012833

Summaries for IER2 Gene

GeneCards Summary for IER2 Gene

IER2 (Immediate Early Response 2) is a Protein Coding gene. An important paralog of this gene is IER5L.

UniProtKB/Swiss-Prot for IER2 Gene

  • DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).

Additional gene information for IER2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER2 Gene

Genomics for IER2 Gene

Regulatory Elements for IER2 Gene

Enhancers for IER2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H013030 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -116.0 -115990 8.2 PKNOX1 FOXA2 ARID4B FEZF1 GLI4 BRCA1 ZNF2 YY1 GLIS2 ZNF143 TRMT1 ZNF844 ZNF791 ZNF442 ZNF136 ZNF625 MRI1 RPS6P25 STX10 ZNF433
GH19H013181 1.3 Ensembl ENCODE dbSUPER 12.6 +31.6 31645 1 PKNOX1 MAX ZNF384 ZFHX2 EGR1 POLR2A EED ATF7 ETV6 RUNX3 STX10 IER2 GC19P013200 RPL12P42
GH19H013068 1.3 ENCODE dbSUPER 11.3 -80.6 -80578 3.3 HDGF ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 LYL1 TRMT1 NACC1 STX10 IER2 RNASEH2A ENSG00000267610 PIR45233
GH19H013042 1.3 FANTOM5 ENCODE dbSUPER 11.2 -106.4 -106443 3 CEBPG ZIC2 ZNF324 ZFHX2 POLR2A SCRT2 PATZ1 ZNF600 ATF7 EGR2 TRMT1 ZNF20 ZNF490 LYL1 NACC1 RNASEH2A NFIX DAND5 GADD45GIP1 DCAF15
GH19H013247 0.9 Ensembl ENCODE 11.9 +97.4 97400 0.8 ELF3 CTCF TEAD1 REST RAD21 TEAD3 CTBP1 IKZF1 GLIS1 ZNF143 IER2 STX10 CACNA1A GC19P013250 GC19P013251 GC19P013252 GC19M013244
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IER2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IER2 Gene

Genomic Locations for IER2 Gene
chr19:13,150,415-13,154,908
(GRCh38/hg38)
Size:
4,494 bases
Orientation:
Plus strand
chr19:13,261,229-13,265,722
(GRCh37/hg19)

Genomic View for IER2 Gene

Genes around IER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER2 Gene

Proteins for IER2 Gene

  • Protein details for IER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTL4-IER2_HUMAN
    Recommended name:
    Immediate early response gene 2 protein
    Protein Accession:
    Q9BTL4
    Secondary Accessions:
    • Q03827
    • Q2TAZ2

    Protein attributes for IER2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IER2 Gene

Post-translational modifications for IER2 Gene

  • Ubiquitination at posLast=55 and isoforms=203
  • Modification sites at PhosphoSitePlus

Other Protein References for IER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER2 Gene

Domains & Families for IER2 Gene

Gene Families for IER2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTL4

UniProtKB/Swiss-Prot:

IER2_HUMAN :
  • Belongs to the IER family.
Family:
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER2: view

Function for IER2 Gene

Molecular function for IER2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
UniProtKB/Swiss-Prot Induction:
By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).

Phenotypes From GWAS Catalog for IER2 Gene

Gene Ontology (GO) - Molecular Function for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19584537
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 19584537
GO:0003677 DNA binding IEA,IDA 19584537
genes like me logo Genes that share ontologies with IER2: view
genes like me logo Genes that share phenotypes with IER2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER2 Gene

Localization for IER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IER2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. {ECO:0000269 PubMed:22120713}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22120713
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 22120713
genes like me logo Genes that share ontologies with IER2: view

Pathways & Interactions for IER2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030182 neuron differentiation ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 19584537
GO:0048870 cell motility IMP 22120713
GO:0071774 response to fibroblast growth factor ISS --
genes like me logo Genes that share ontologies with IER2: view

No data available for Pathways by source and SIGNOR curated interactions for IER2 Gene

Drugs & Compounds for IER2 Gene

No Compound Related Data Available

Transcripts for IER2 Gene

mRNA/cDNA for IER2 Gene

Unigene Clusters for IER2 Gene

Immediate early response 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for IER2 Gene

GeneLoc Exon Structure for
IER2
ECgene alternative splicing isoforms for
IER2

Expression for IER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IER2 Gene

This gene is overexpressed in Fallopian Tube (x4.5) and Whole Blood (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IER2 Gene



NURSA nuclear receptor signaling pathways regulating expression of IER2 Gene:

IER2

SOURCE GeneReport for Unigene cluster for IER2 Gene:

Hs.501629

mRNA Expression by UniProt/SwissProt for IER2 Gene:

Q9BTL4-IER2_HUMAN
Tissue specificity: Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).

Evidence on tissue expression from TISSUES for IER2 Gene

  • Nervous system(4.5)
  • Intestine(4.4)
  • Kidney(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with IER2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER2 Gene

Orthologs for IER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IER2 33
  • 97.01 (n)
dog
(Canis familiaris)
Mammalia IER2 33 34
  • 87.84 (n)
cow
(Bos Taurus)
Mammalia IER2 33 34
  • 86.73 (n)
rat
(Rattus norvegicus)
Mammalia Ier2 33
  • 80.37 (n)
mouse
(Mus musculus)
Mammalia Ier2 33 16 34
  • 79.3 (n)
oppossum
(Monodelphis domestica)
Mammalia IER2 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IER2 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IER2 34
  • 36 (a)
OneToOne
Species where no ortholog for IER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER2 Gene

ENSEMBL:
Gene Tree for IER2 (if available)
TreeFam:
Gene Tree for IER2 (if available)

Paralogs for IER2 Gene

Paralogs for IER2 Gene

genes like me logo Genes that share paralogs with IER2: view

Variants for IER2 Gene

Sequence variations from dbSNP and Humsavar for IER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000264223 -- 13,151,707(+) GGAAT(A/G)CGAGT intron-variant, upstream-variant-2KB
rs1000314104 -- 13,152,715(+) TGTGA(A/T)GGGAA intron-variant
rs1000698409 -- 13,151,415(+) GGGAC(G/T)GGAGG intron-variant, upstream-variant-2KB
rs1001019889 -- 13,155,325(+) AAGGG(C/T)TCTTT downstream-variant-500B
rs1001054108 -- 13,155,181(+) CTGCC(C/G)CAAGC downstream-variant-500B

Variation tolerance for IER2 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER2 Gene

Human Gene Mutation Database (HGMD)
IER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IER2 Gene

Disorders for IER2 Gene

Relevant External Links for IER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IER2

No disorders were found for IER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER2 Gene

Publications for IER2 Gene

  1. Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PMID: 2061303) Shimizu N … Utiyama H (The Journal of biological chemistry 1991) 2 3 4 22 60
  2. The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients. (PMID: 22120713) Neeb A … Sleeman JP (Oncogene 2012) 3 4 60
  3. Functional analyses of immediate early gene ETR101 expressed in yeast. (PMID: 19584537) Takaya T … Nikawa J (Bioscience, biotechnology, and biochemistry 2009) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for IER2 Gene

Sources for IER2 Gene

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