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IER2 Gene

protein-coding   GIFtS: 50
GCID: GC19P013261

Immediate Early Response 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immediate Early Response 21 2
ETR1012 3
Immediate Early Response Gene 2 Protein2
Protein ETR1013

External Ids:    HGNC: 288711   Entrez Gene: 95922   Ensembl: ENSG000001608887   UniProtKB: Q9BTL43   

Export aliases for IER2 gene to outside databases

Previous GC identifers: GC19P013124 GC19P013122 GC19P012833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IER2 Gene:
IER2 (immediate early response 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the IER2 gene promoter:
         ATF-2   NF-kappaB   c-Ets-1   CREB   CRE-BP1   deltaCREB   c-Myb   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER2 promoter sequence
   Search Chromatin IP Primers for IER2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

IER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013261:  view genomic region     (about GC identifiers)

Start:
13,261,229 bp from pter      End:
13,265,722 bp from pter
Size:
4,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4 (See protein sequence)
Recommended Name: Immediate early response gene 2 protein  
Size: 223 amino acids; 24196 Da
Secondary accessions: Q03827 Q2TAZ2

Explore the universe of human proteins at neXtProt for IER2: NX_Q9BTL4

Explore proteomics data for IER2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys203
  • Modification sites at PhosphoSitePlus

  • See IER2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004898.2  
    ENSEMBL proteins: 
     ENSP00000467294   ENSP00000292433   ENSP00000465617  

    IER2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008653 IER

    Graphical View of Domain Structure for InterPro Entry Q9BTL4

    ProtoNet protein and cluster: Q9BTL4

    UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4
    Similarity: Belongs to the IER family


    Find genes that share domains with IER2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IER2_HUMAN, Q9BTL4
    Induction: By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA)

    Phenotypes:
         1 GenomeRNAi human phenotype for IER2:

     Small cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IER2
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    miRTarBase miRNAs that target IER2:
    hsa-mir-18a-3p (MIRT040855)

    Block miRNA regulation of human, mouse, rat IER2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IER2 (see all 16):
    hsa-miR-30c hsa-miR-1226 hsa-miR-4271 hsa-miR-125a-5p hsa-miR-30d hsa-miR-488 hsa-miR-504 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIER2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IER2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with IER2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IER2
    Interactions:

        Search GeneGlobe Interaction Network for IER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for IER2 (Q9BTL43 ENSP000002924334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    FIBPENSP000003445724STRING: ENSP00000344572
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IER2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IER2 gene: 
    NM_004907.2  

    Unigene Cluster for IER2:

    Immediate early response 2
    Hs.501629  [show with all ESTs]
    Unigene Representative Sequence: BC110647
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587885 ENST00000292433(uc002mwr.3) ENST00000588173
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IER2 (see all 16):
    hsa-miR-30c hsa-miR-1226 hsa-miR-4271 hsa-miR-125a-5p hsa-miR-30d hsa-miR-488 hsa-miR-504 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIER2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IER2 (NM_004907)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER2
    Primer
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    OriGene qPCR primer pairs and template standards for IER2
    OriGene qSTAR qPCR primer pairs in human, mouse for IER2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IER2
      QuantiTect SYBR Green Assays in human, mouse, rat IER2
      QuantiFast Probe-based Assays in human, mouse, rat IER2

    Additional mRNA sequence: 

    BC003625.2 BC072432.1 BC110647.1 BT019466.1 CR450352.1 M62831.1 S69623.1 

    19 DOTS entries:

    DT.117934  DT.95264086  DT.95264087  DT.100719222  DT.100875572  DT.100875592  DT.95117131  DT.121436763 
    DT.91809226  DT.100875564  DT.100875557  DT.100875584  DT.97778767  DT.100875568  DT.100875570  DT.121164568 
    DT.121436664  DT.100875590  DT.92066305 

    Selected AceView cDNA sequences (see all 447):

    CR595783 CR607279 BX281546 AI379161 CR622473 CK906322 CB161690 BG899820 
    CR610628 CR595984 T60794 CR607809 BX330057 AW081053 BE073499 BM552739 
    BM713209 CR603024 BU848731 CR625573 CR595420 AI269617 CR593038 AI091455 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IER2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for IER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGGCGT
    IER2 Expression
    About this image


    IER2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             AII Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer
    IER2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IER2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501629
        Custom PCR Arrays for IER2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IER2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ier21 , 5 immediate early response 21, 5 79.3(n)1
    79.91(a)1
      8 (41.02 cM)5
    159361  NM_010499.41  NP_034629.31 
     846613315 
    zebrafish
    (Danio rerio)
    Actinopterygii IER26
    immediate early response 2
    36(a)
    1 ↔ 1
    11(31914386-31914898) ENSDARG00000086881


    ENSEMBL Gene Tree for IER2 (if available)
    TreeFam Gene Tree for IER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IER2 (see all 64)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37609121,2
    C,F,H--13263338(-) TCGGAG/AGATAC 1 -- int118Minor allele frequency- A:0.11NS EA NA WA 2330
    rs126103101,2
    C,H--13263500(+) GTTCAG/AGCTGG 1 -- int12Minor allele frequency- A:0.00NA 4
    rs38269131,2
    C,F,H--13263510(-) GACCCG/TGGTTC 1 -- int125Minor allele frequency- T:0.06NS EA NA WA CSA 2235
    rs1851614551,2
    --13263513(+) CCAGGA/GTCTTC 1 -- int10--------
    rs1888510221,2
    --13263850(+) GGCCTA/GGGTGG 1 -- ut510--------
    rs1114669721,2
    C--13263868(+) CTGGGG/CAGAGC 1 -- ut511Minor allele frequency- C:0.00CSA 1
    rs1811740981,2
    --13263896(+) GCGTGA/GGTTGG 1 -- ut510--------
    rs1862208571,2
    --13263951(+) TGCTGC/TCTGTT 1 -- ut510--------
    rs1482786821,2
    C,F--13264042(+) CTGTCG/AGTGTG 2 /S syn11Minor allele frequency- A:0.00NA 3884
    rs1916377031,2
    C--13264051(+) TGGAAA/GATGTA 2 K syn10--------

    HapMap Linkage Disequilibrium report for IER2 (13261229 - 13265722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IER2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911087CNV Loss21882294
    dgv3737n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IER2
    DNA2.0 Custom Variant and Variant Library Synthesis for IER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IER2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with IER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PubMed id 2061303)1, 2, 3, 9 Shimizu N....Utlyama H. (J. Biol. Chem. 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    4. The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients. (PubMed id 22120713)1 Neeb A....Sleeman J.P. (Oncogene 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Functional analyses of immediate early gene ETR101 expressed in yeast. (PubMed id 19584537)1 Takaya T....Nikawa J. (Biosci. Biotechnol. Biochem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9592 HGNC: 28871 AceView: IER2.1 Ensembl:ENSG00000160888 euGenes: HUgn9592
    ECgene: IER2 H-InvDB: IER2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IER2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IER2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IER2 gene:
    Search GeneIP for patents involving IER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for IER2 Search Chromatin IP Primers for IER2
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     Search Addgene for plasmids for IER2
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      eBioscience FlowRNA Probe Sets
           
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