V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

IER2 Gene

protein-coding GIFtS: 51

GC19P013122

immediate early response 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ETR101 ^¹, ², ³
MGC111472 ^²
MGC15265 ^²

Descriptions
Protein ETR101 ^³
immediate early response 2 ^²

External Ids
HGNC: 28871¹
Entrez Gene: 9592²
UniProtKB: Q9BTL4³
Ensembl: ENSG00000160888⁷

Search outside databases for aliases for IER2 gene

Previous GC identifer: GC19P013124

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IER2 gene

Entrez Gene cytogenetic band: 19p13.13 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.13

IER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P013122: (about GC identifiers)

Start:	13,122,282 bp from pter
End:	13,126,722 bp from pter
Size:	4,441 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4 (See protein sequence)

Recommended Name: Immediate early response gene 2 protein

Size: 223 amino acids; 24196 Da

Secondary accessions: Q03827 Q2TAZ2

REFSEQ proteins: NP_004898.2

ENSEMBL proteins:

ENSP00000292433 ENSP00000376859

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IER2)
	Human Recombinant Proteins from Abnova (IER2)

OriGene Purified Recombinant Human Protein: IER2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for IER2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IER2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IER2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IER2)
	Novus Biologicals Antibody for IER2

Assays for IER2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BTL4

ProtoNet protein and cluster: Q9BTL4

UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4

Similarity: Belongs to the IER family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IER2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004907

Applied Biosystems Silencer® siRNAs for IER2

Sigma-Aldrich siRNA for IER2

Sigma-Aldrich shRNA for IER2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IER2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004907
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004907
untagged cDNA clones in CMV expression vector (see all 2): NM_004907

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004907

UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4

Induction: By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for IER2 (ENSP00000292433³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGR1	ENSP00000239938³	STRING (score=.728)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IER2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IER2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004907

Sigma-Aldrich siRNA for IER2

Sigma-Aldrich shRNA for IER2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004907

REFSEQ mRNAs for IER2 gene:

NM_004907.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004907

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004907
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004907
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004907

Additional cDNA sequence:

BC003625.2 BC072432.1 BC110647.1 BT019466.1 CR450352.1 CR592233.1 CR593038.1 CR595420.1

CR595783.1 CR595984.1 CR596913.1 CR596965.1 CR597130.1 CR601806.1 CR602141.1 CR602346.1

CR603024.1 CR603448.1 CR606790.1 CR606860.1 CR606997.1 CR607279.1 CR607809.1 CR608502.1

CR608672.1 CR610628.1 CR613150.1 CR613699.1 CR614886.1 CR619168.1 CR620054.1 CR621121.1

CR622473.1 CR625470.1 CR625552.1 CR625573.1 M62831.1 S69623.1

19 DOTS entries:

DT.117934 DT.95264086 DT.95264087 DT.100719222 DT.100875572 DT.95117131 DT.100875592 DT.91809226

DT.97778767 DT.121436763 DT.100875557 DT.100875584 DT.121164568 DT.121436664 DT.100875564 DT.100875568

DT.100875570 DT.100875590 DT.92066305

24/447 AceView cDNA sequences (see all 447 ):

CR596965 BU902177 CR606860 CR593038 CR610628 BX330256 CR614886 AW272884

T40318 CR595420 BM126882 AI091455 CR603448 CR596913 AA911558 CR613150

BM989029 BX330057 BM552739 BM765784 BU153373 CR620054 AI633483 CR601806

highest scoring ESTs for IER2:

M62831 AA129801 AA248733 AA251470 AA258008 AA281345 AA310147 AA344677 AA400797 AA410757

Unigene Cluster for IER2:

Immediate early response 2

Hs.501629 [show with all ESTs]

Unigene Representative Sequence: BC110647

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IER2

ExUns:	1a	·	1b	^	2a	·	2b	·	2c
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for IER2

2 Ensembl transcripts including schematic representations:

ENST00000292433 ENST00000393152

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IER2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IER2

¹ / ² / ³

3 probe-sets matching IER2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36097_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M62831	1.00	1.00	1.00	1
202081_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004907	0.60	1.00	0.82	1
202081_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGCAGGCGT

SOURCE GeneReport for Unigene cluster: Hs.501629
Expression variation in blood from EXPOLDB for IER2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IER2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IER2¹	--	immediate early response 2	87.84(n) 89.19(a)	484917 XM_542033.2 XP_542033.2
cow (Bos taurus)	IER2¹	--	immediate early response 2	86.73(n) 86.43(a)	525380 NM_001075871.1 NP_001069339.1
rat (Rattus norvegicus)	Ier2¹	--	immediate early response 2	80.21(n) 80.37(a)	494344 NM_001009541.1 NP_001009541.1
mouse (Mus musculus)	Ier2^{1, 5}	8 (38.40 cM)⁵	immediate early response 2^{1, 5}	78.69(n)¹ 79(a)¹	15936¹ NM_010499.3¹ NP_034629.2¹ AI317238⁵ AI644264⁵ (see all 19)

About this table Species with no ortholog for IER2

ENSEMBL Gene Tree for IER2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IER2 gene

IER5L² IER5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/13 NCBI SNPs in IER2 are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1042164^1,2	C,F,H	13125398(+)	`GGACGC/TTGGAC`	1	A/V	mis¹ ese³		5		MN EU EA WA	604
	rs3745992^1,2	A,C,F	13126270(-)	`GGGCGG/AGTGCA`	1	--	ut3¹ ese³		1		EA	1504
	rs879989^1,2	C,F	13127150(+)	`AGTCCC/TCAGTT`	1	--	ng3¹		1		MN	184
--	rs3174806^1,2	C	13126641(+)	`TCGTGC/TGGTGG`	1	--	ut3¹ ese³		0	--	--	--	--
	rs3760912^1,2	C,F,H	13124338(-)	`TCGGAG/AGATAC`	1	--	int¹		4		EU EA WA	420
	rs3826913^1,2	C	13124510(-)	`GACCCG/TGGTTC`	1	--	int¹		0	--	--	--	--
--	rs36093561^1,2	--	13125872(+)	`GGGAC-/AGGCAC`	1	--	ut3¹		0	--	--	--	--
	rs3760911^1,2	--	13126986(-)	`AGTGTA/GTTTAG`	1	--	ng3¹		0	--	--	--	--
--	rs34440056^1,2	--	13126204(+)	`GGGCA-/GGCGTG`	1	--	ut3¹		0	--	--	--	--
	rs1042165^1,2	--	13125468(+)	`GAAGTC/GGCCGA`	1	V/V	syn¹ ese³		1		MN	184

About this table

HapMap Linkage Disequilibrium images for IER2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for IER2 gene:

Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PubMed id 2061303)^{1, 2, 3, 4} Shimizu N....Utlyama H. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins. (PubMed id 8392623)¹ Furnari B.A....Huang E.S. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9592	HGNC: 28871	AceView: IER2.1	Ensembl:ENSG00000160888	euGenes: HUgn9592
ECgene: IER2	H-InvDB: IER2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IER2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for IER2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IER2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IER2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IER2		Antibodies for IER2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IER2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IER2)
	Antibodies (IER2)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IER2)
	Antibodies (IER2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for IER2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IER2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IER2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

IER2 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for IER2

Summaries
for IER2

Genomic Location
for IER2

Proteins
for IER2

Protein Domains/
Families
for IER2

Gene Function
for IER2

Pathways & Interactions
for IER2

Drugs & Compounds
for IER2

Transcripts
for IER2

Expression
for IER2

Orthologs
for IER2

Paralogs
for IER2

SNPs/Variants
for IER2

Disorders & Mutations
for IER2

Medical News
for IER2

Publications
for IER2

Search for IER2

Genome Databases showing IER2

Other Databases showing IER2

Specialized Databases showing IER2

Licensable Technologies
for IER2

Services
for IER2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IER2 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor IER2

Summariesfor IER2

Genomic Locationfor IER2

Proteinsfor IER2

Protein Domains/Familiesfor IER2

Gene Functionfor IER2

Pathways & Interactionsfor IER2

Drugs & Compoundsfor IER2

Transcriptsfor IER2

Expression for IER2

Orthologsfor IER2

Paralogsfor IER2

SNPs/Variantsfor IER2

Disorders & Mutationsfor IER2

Medical Newsfor IER2

Publicationsfor IER2

Search for IER2

Genome Databases showing IER2

Other Databases showing IER2

Specialized Databases showing IER2

Licensable Technologiesfor IER2

Servicesfor IER2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IER2

Summaries
for IER2

Genomic Location
for IER2

Proteins
for IER2

Protein Domains/
Families
for IER2

Gene Function
for IER2

Pathways & Interactions
for IER2

Drugs & Compounds
for IER2

Transcripts
for IER2

Expression
for IER2

Orthologs
for IER2

Paralogs
for IER2

SNPs/Variants
for IER2

Disorders & Mutations
for IER2

Medical News
for IER2

Publications
for IER2

Licensable Technologies
for IER2

Services
for IER2