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Aliases for IER2 Gene

Aliases for IER2 Gene

  • Immediate Early Response 2 2 3
  • ETR101 3 4
  • ChxI Protein Homolog 3
  • Protein ETR101 4
  • PIP92 4

External Ids for IER2 Gene

Previous GeneCards Identifiers for IER2 Gene

  • GC19P013124
  • GC19P013122
  • GC19P013261
  • GC19P012833

Summaries for IER2 Gene

GeneCards Summary for IER2 Gene

IER2 (Immediate Early Response 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IER2 Gene

  • DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER2 Gene

Genomics for IER2 Gene

Regulatory Elements for IER2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IER2 Gene

Chromosome:
19
Start:
13,150,415 bp from pter
End:
13,154,908 bp from pter
Size:
4,494 bases
Orientation:
Plus strand

Genomic View for IER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER2 Gene

Proteins for IER2 Gene

  • Protein details for IER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTL4-IER2_HUMAN
    Recommended name:
    Immediate early response gene 2 protein
    Protein Accession:
    Q9BTL4
    Secondary Accessions:
    • Q03827
    • Q2TAZ2

    Protein attributes for IER2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IER2 Gene

Proteomics data for IER2 Gene at MOPED

Post-translational modifications for IER2 Gene

  • Ubiquitination at Lys 5 and Lys 203
  • Modification sites at PhosphoSitePlus

Other Protein References for IER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER2 Gene

Domains & Families for IER2 Gene

Protein Domains for IER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTL4

UniProtKB/Swiss-Prot:

IER2_HUMAN :
  • Belongs to the IER family.
Family:
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER2: view

No data available for Gene Families for IER2 Gene

Function for IER2 Gene

Molecular function for IER2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
UniProtKB/Swiss-Prot Induction:
By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).

Gene Ontology (GO) - Molecular Function for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 19584537
genes like me logo Genes that share ontologies with IER2: view

Phenotypes for IER2 Gene

GenomeRNAi human phenotypes for IER2:
genes like me logo Genes that share phenotypes with IER2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IER2 Gene

Localization for IER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IER2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. {ECO:0000269 PubMed:22120713}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IER2 Gene COMPARTMENTS Subcellular localization image for IER2 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22120713
GO:0005737 cytoplasm IDA 22120713
genes like me logo Genes that share ontologies with IER2: view

Pathways & Interactions for IER2 Gene

SuperPathways for IER2 Gene

No Data Available

Interacting Proteins for IER2 Gene

Gene Ontology (GO) - Biological Process for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation ISS --
GO:0048870 cell motility IMP 22120713
GO:0071774 response to fibroblast growth factor ISS --
genes like me logo Genes that share ontologies with IER2: view

No data available for Pathways by source and SIGNOR curated interactions for IER2 Gene

Drugs & Compounds for IER2 Gene

No Compound Related Data Available

Transcripts for IER2 Gene

mRNA/cDNA for IER2 Gene

Unigene Clusters for IER2 Gene

Immediate early response 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IER2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for IER2 Gene

GeneLoc Exon Structure for
IER2
ECgene alternative splicing isoforms for
IER2

Expression for IER2 Gene

mRNA expression in normal human tissues for IER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IER2 Gene

This gene is overexpressed in Fallopian Tube (x4.5) and Whole Blood (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IER2 Gene



SOURCE GeneReport for Unigene cluster for IER2 Gene Hs.501629

mRNA Expression by UniProt/SwissProt for IER2 Gene

Q9BTL4-IER2_HUMAN
Tissue specificity: Expressed in activated T cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).
genes like me logo Genes that share expression patterns with IER2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for IER2 Gene

Orthologs for IER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia IER2 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ier2 36
  • 79 (a)
OneToOne
Ier2 16
Ier2 35
  • 79.3 (n)
  • 79.91 (a)
oppossum
(Monodelphis domestica)
Mammalia IER2 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IER2 36
  • 89 (a)
OneToOne
IER2 35
  • 87.84 (n)
  • 88.74 (a)
cow
(Bos Taurus)
Mammalia IER2 36
  • 86 (a)
OneToOne
IER2 35
  • 86.73 (n)
  • 86.43 (a)
rat
(Rattus norvegicus)
Mammalia Ier2 35
  • 80.37 (n)
  • 79.91 (a)
chimpanzee
(Pan troglodytes)
Mammalia IER2 35
  • 97.01 (n)
  • 96.4 (a)
zebrafish
(Danio rerio)
Actinopterygii IER2 36
  • 36 (a)
OneToOne
Species with no ortholog for IER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER2 Gene

ENSEMBL:
Gene Tree for IER2 (if available)
TreeFam:
Gene Tree for IER2 (if available)

Paralogs for IER2 Gene

No data available for Paralogs for IER2 Gene

Variants for IER2 Gene

Sequence variations from dbSNP and Humsavar for IER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs775248277 -- 13,153,810(+) CGCCC(A/G)GCGGA synonymous-codon, reference
rs775185485 -- 13,154,866(+) TTTGT(C/T)AGAAA utr-variant-3-prime
rs774688181 -- 13,153,371(+) GTTGC(C/T)GGCCG reference, missense
rs774239108 -- 13,153,992(+) CCGCC(A/C)GGGCT utr-variant-3-prime
rs774076379 -- 13,153,523(+) GTGCC(C/G)CGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IER2 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3737n71 CNV Loss 21882294

Variation tolerance for IER2 Gene

Residual Variation Intolerance Score: 50.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IER2 Gene

HapMap Linkage Disequilibrium report
IER2
Human Gene Mutation Database (HGMD)
IER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER2 Gene

Disorders for IER2 Gene

Relevant External Links for IER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IER2
genes like me logo Genes that share disorders with IER2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER2 Gene

Publications for IER2 Gene

  1. Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PMID: 2061303) Shimizu N. … Utlyama H. (J. Biol. Chem. 1991) 2 23 67
  2. Multifaceted evasion of the interferon response by cytomegalovirus. (PMID: 19708810) Marshall E.E. … Geballe A.P. (J. Interferon Cytokine Res. 2009) 23 67
  3. Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins. (PMID: 8392623) Furnari B.A. … Huang E.S. (J. Virol. 1993) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients. (PMID: 22120713) Neeb A. … Sleeman J.P. (Oncogene 2012) 67

Products for IER2 Gene

Sources for IER2 Gene

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