Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IER2 Gene

protein-coding   GIFtS: 48
GCID: GC19P013261

immediate early response 2

 Explore 1 disease affiliated with
IER2 via our new
 Human Malady Compendium 
Biological research products
for IER2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Immediate Early Response 21 2
ETR1011 2 3
Immediate Early Response Gene 2 Protein2
Protein ETR1013

External Ids:    HGNC: 288711   Entrez Gene: 95922   Ensembl: ENSG000001608887   UniProtKB: Q9BTL43   

Export aliases for IER2 gene to outside databases

Previous GC identifers: GC19P013124 GC19P013122 GC19P012833


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IER2 gene promoter:
         ATF-2   NF-kappaB   c-Ets-1   CREB   CRE-BP1   deltaCREB   c-Myb   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IER2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IER2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

IER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IER2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013261:  view genomic region     (about GC identifiers)

Start:
13,261,229 bp from pter      End:
13,265,722 bp from pter
Size:
4,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4 (See protein sequence)
Recommended Name: Immediate early response gene 2 protein  
Size: 223 amino acids; 24196 Da
Secondary accessions: Q03827 Q2TAZ2

Explore the universe of human proteins at neXtProt for IER2: NX_Q9BTL4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BTL4

  • IER2 Protein expression data from MOPED and PaxDb:    About this image 
    IER2 Protein Expression
    REFSEQ proteins: NP_004898.2  
    ENSEMBL proteins: 
     ENSP00000467294   ENSP00000292433   ENSP00000465617  

    Human Recombinant Protein Products for IER2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IER2
    OriGene Custom Protein Services for IER2 
    GenScript Custom Purified and Recombinant Proteins Services for IER2
    Novus Biologicals IER2 Protein
    Novus Biologicals IER2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IER2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    IER2 for ontologies           About GeneDecksing



    IER2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IER2 
    GenScript Custom Superior Antibodies Services for IER2
    Novus Biologicals IER2 Antibodies
    Abcam antibodies for IER2 
    Uscn Antibodies for IER2
    Search ThermoFisher Antibodies for IER2

    Assay Products for IER2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IER2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IER2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IER2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008653 IER

    Graphical View of Domain Structure for InterPro Entry Q9BTL4

    ProtoNet protein and cluster: Q9BTL4

    UniProtKB/Swiss-Prot: IER2_HUMAN, Q9BTL4
    Similarity: Belongs to the IER family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IER2_HUMAN, Q9BTL4
    Induction: By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA)

    Phenotypes:
         1 GenomeRNAi human phenotype for IER2:

     Small cells 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IER2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: IER2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IER2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IER2 (see all 16):
    hsa-miR-30c hsa-miR-1226 hsa-miR-4271 hsa-miR-125a-5p hsa-miR-30d hsa-miR-488 hsa-miR-504 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIER2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IER2 (see all 7)
    OriGene shRNA RFP: IER2
    OriGene siRNA: IER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IER2
    Sirion Biotech Custom design and validation of potent shRNA sequences against IER2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IER2
    Sirion Biotech Customized adenovirus for overexpression of IER2 
    Sirion Biotech Customized adenovirus for potent knockdown of IER2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IER2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IER2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IER2 (NM_004907)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IER2
    Search LifeMap BioReagents cell lines for IER2
    Sirion Biotech Customized stable knockdown cell line services for IER2 
    Sirion Biotech Customized inducible knockdown cell line services for IER2
    Sirion Biotech Customized stable overexpressing cell line services for IER2
    Sirion Biotech Customized inducible overexpressing cell line services for IER2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for IER2 (Q9BTL43 ENSP000002924334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    FIBPENSP000003445724STRING: ENSP00000344572
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IER2
    Search CenterWatch for drugs/clinical trials and news about IER2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IER2 gene: 
    NM_004907.2  

    Unigene Cluster for IER2:

    Immediate early response 2
    Hs.501629  [show with all ESTs]
    Unigene Representative Sequence: BC110647
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587885 ENST00000292433(uc002mwr.3) ENST00000588173

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: IER2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IER2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IER2 (see all 16):
    hsa-miR-30c hsa-miR-1226 hsa-miR-4271 hsa-miR-125a-5p hsa-miR-30d hsa-miR-488 hsa-miR-504 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIER2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IER2 (see all 7)
    OriGene shRNA RFP: IER2
    OriGene siRNA: IER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IER2
    Sirion Biotech Custom design and validation of potent shRNA sequences against IER2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IER2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IER2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IER2 (NM_004907)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IER2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IER2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IER2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IER2

    Additional cDNA sequence: 

    BC003625.2 BC072432.1 BC110647.1 BT019466.1 CR450352.1 M62831.1 S69623.1 

    19 DOTS entries:

    DT.117934  DT.95264086  DT.95264087  DT.100719222  DT.100875572  DT.100875592  DT.95117131  DT.121436763 
    DT.91809226  DT.100875564  DT.100875557  DT.100875584  DT.97778767  DT.100875568  DT.100875570  DT.121164568 
    DT.121436664  DT.100875590  DT.92066305 

    24/447 AceView cDNA sequences (see all 447):

    CR607809 CR602141 CR595420 CR622473 BQ953666 BX330057 BM552739 CR613150 
    CR606860 AI633483 CR592233 BX434293 CR603448 CR601806 AI095862 AW006678 
    CR613699 BM819855 CR619168 BM989029 AA913281 BM675073 CR595783 CR625552 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IER2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for IER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCAGGCGT
    IER2 Expression
    About this image

    IER2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IER2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IER2

    SOURCE GeneReport for Unigene cluster: Hs.501629
        SABiosciences Custom PCR Arrays for IER2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IER2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IER2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IER2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IER2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IER2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ier21 , 5 immediate early response 21, 5 79.15(n)1
    80.37(a)1
      8 (41.02 cM)5
    159361  NM_010499.41  NP_034629.31 
     846613315 
    zebrafish
    (Danio rerio)
    Actinopterygii CR855274.16
    --
    38(a)
    1 ↔ 1
    11(31914386-31914898)


    ENSEMBL Gene Tree for IER2 (if available)
    TreeFam Gene Tree for IER2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IER2 gene
    IER5L2  IER52  
    1 SIMAP similar gene for IER2 using alignment to 1 protein entry:     IER2_HUMAN:
    IER5

    IER2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/51 NCBI SNPs in IER2 are shown (see all 51    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557244771,2
    C--13263055(+) GGGGAG/CTGTCG 5 -- int1 us2k14Minor allele frequency- C:0.49WA NA EA 360
    rs1457183071,2
    --13263130(+) TGCGGG/TGGAAT 5 -- us2k1 int10--------
    rs767837031,2
    C--13263146(+) GGTACG/CAATCA 5 -- int1 us2k13Minor allele frequency- C:0.05CSA WA NA 240
    rs37609121,2
    C,F,H--13263338(-) TCGGAG/AGATAC 1 -- int118Minor allele frequency- A:0.11NS EA NA WA 2330
    rs126103101,2
    C,H--13263500(+) GTTCAG/AGCTGG 1 -- int12Minor allele frequency- A:0.00NA 4
    rs38269131,2
    C,F,H--13263510(-) GACCCG/TGGTTC 1 -- int125Minor allele frequency- T:0.06NS EA NA WA CSA 2235
    rs1851614551,2
    --13263513(+) CCAGGA/GTCTTC 1 -- int10--------
    rs1888510221,2
    --13263850(+) GGCCTA/GGGTGG 1 -- ut510--------
    rs1114669721,2
    C--13263868(+) CTGGGG/CAGAGC 1 -- ut511Minor allele frequency- C:0.00CSA 1
    rs1811740981,2
    --13263896(+) GCGTGA/GGTTGG 1 -- ut510--------

    HapMap Linkage Disequilibrium report for IER2 (13261229 - 13265722 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IER2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IER2
    DNA2.0 Custom Variant and Variant Library Synthesis for IER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IER2 for disorders           About GeneDecksing

    1 disease for IER2:    About MalaCards
    trachoma


    Export disorders for IER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IER2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with IER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PubMed id 2061303)1, 2, 3, 9 Shimizu N....Utlyama H. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    4. The immediate early gene Ier2 promotes tumor cell moti lity and metastasis, and predicts poor survival of colorectal cancer patients. (PubMed id 22120713)1 Neeb A....Sleeman J.P. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    8. Functional analyses of immediate early gene ETR101 ex pressed in yeast. (PubMed id 19584537)1 Takaya T....Nikawa J. (2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9592 HGNC: 28871 AceView: IER2.1 Ensembl:ENSG00000160888 euGenes: HUgn9592
    ECgene: IER2 H-InvDB: IER2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IER2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IER2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IER2 gene:
    Search GeneIP for patents involving IER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for IER2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IER2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IER2  
     OriGene Protein Over-expression Lysate for IER2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IER2   OriGene 3'-UTR Clone for IER2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IER2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IER2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IER2   OriGene Custom Protein Services for IER2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IER2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IER2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IER2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IER2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IER2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IER2
     GenScript Custom Purified and Recombinant Proteins Services for IER2 GenScript cDNA clones with any tag delivered in your preferred vector for IER2
     GenScript Custom Assay Services for IER2 GenScript Custom Superior Antibodies Services for IER2
     GenScript Custom overexpressing Cell Line Services for IER2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IER2 promoter
     Search Chromatin IP Primers for IER2
     RT2 qPCR Primer Assay in human, mouse, rat IER2
     Search GNC Networks for IER2
     SABiosciences Custom PCR Arrays for IER2
     Search Tocris compounds for IER2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IER2 antibodies
     IER2 proteins
     IER2 lysates
     Antibodies for IER2
     See all of Abcam's Antibodies, Kits and Proteins for IER2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IER2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IER2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IER2
     SwitchGear 3'UTR luciferase reporter plasmids for IER2
     SwitchGear Promoter luciferase reporter plasmids for IER2
     Search ThermoFisher Antibodies for IER2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IER2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IER2
    Sirion Biotech Customized:
     stable knockdown cell line services for IER2
     inducible knockdown cell line services for IER2
     design and validation of potent shRNA sequences against IER2
     adenovirus for potent knockdown of IER2
     adenovirus for overexpression of IER2
     stable overexpressing cell line services for IER2
     inducible overexpressing cell line services for IER2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IER2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4