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Aliases for IER2 Gene

Aliases for IER2 Gene

  • Immediate Early Response 2 2 3
  • ETR101 3 4
  • Immediate Early Response Gene 2 Protein 3
  • Protein ETR101 4

External Ids for IER2 Gene

Previous GeneCards Identifiers for IER2 Gene

  • GC19P013124
  • GC19P013122
  • GC19P013261
  • GC19P012833

Summaries for IER2 Gene

GeneCards Summary for IER2 Gene

IER2 (Immediate Early Response 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER2 Gene

Genomics for IER2 Gene

Regulatory Elements for IER2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IER2 Gene

Start:
13,150,415 bp from pter
End:
13,154,908 bp from pter
Size:
4,494 bases
Orientation:
Plus strand

Genomic View for IER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER2 Gene

Proteins for IER2 Gene

  • Protein details for IER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTL4-IER2_HUMAN
    Recommended name:
    Immediate early response gene 2 protein
    Protein Accession:
    Q9BTL4
    Secondary Accessions:
    • Q03827
    • Q2TAZ2

    Protein attributes for IER2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IER2 Gene

Proteomics data for IER2 Gene at MOPED

Post-translational modifications for IER2 Gene

  • Ubiquitination at Lys203
  • Modification sites at PhosphoSitePlus

Other Protein References for IER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER2 Gene

Domains for IER2 Gene

Protein Domains for IER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTL4

UniProtKB/Swiss-Prot:

IER2_HUMAN :
  • Q9BTL4
Family:
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER2: view

No data available for Gene Families for IER2 Gene

Function for IER2 Gene

Molecular function for IER2 Gene

UniProtKB/Swiss-Prot Induction: By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).

Phenotypes for IER2 Gene

GenomeRNAi human phenotypes for IER2:
genes like me logo Genes that share phenotypes with IER2: view

Animal Model Products

CRISPR Products

miRNA for IER2 Gene

miRTarBase miRNAs that target IER2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for IER2 Gene

Localization for IER2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IER2 Gene COMPARTMENTS Subcellular localization image for IER2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for IER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IER2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IER2 Gene

Pathways for IER2 Gene

SuperPathways for IER2 Gene

No Data Available

Interacting Proteins for IER2 Gene

Gene Ontology (GO) - Biological Process for IER2 Gene

None

No data available for Pathways by source for IER2 Gene

Transcripts for IER2 Gene

mRNA/cDNA for IER2 Gene

Unigene Clusters for IER2 Gene

Immediate early response 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IER2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for IER2 Gene

GeneLoc Exon Structure for
IER2
ECgene alternative splicing isoforms for
IER2

Expression for IER2 Gene

mRNA expression in normal human tissues for IER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IER2 Gene

This gene is overexpressed in Fallopian Tube (4.5) and Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IER2 Gene

SOURCE GeneReport for Unigene cluster for IER2 Gene Hs.501629

genes like me logo Genes that share expressions with IER2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IER2 Gene

Orthologs for IER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IER2 35
  • 97.01 (n)
  • 96.4 (a)
cow
(Bos Taurus)
Mammalia IER2 35
  • 86.73 (n)
  • 86.43 (a)
IER2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IER2 35
  • 87.84 (n)
  • 88.74 (a)
IER2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ier2 35
  • 79.3 (n)
  • 79.91 (a)
Ier2 16
Ier2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IER2 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IER2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ier2 35
  • 80.37 (n)
  • 79.91 (a)
zebrafish
(Danio rerio)
Actinopterygii IER2 36
  • 36 (a)
OneToOne
Species with no ortholog for IER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER2 Gene

ENSEMBL:
Gene Tree for IER2 (if available)
TreeFam:
Gene Tree for IER2 (if available)

Paralogs for IER2 Gene

No data available for Paralogs for IER2 Gene

Variants for IER2 Gene

Sequence variations from dbSNP and Humsavar for IER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs879989 -- 13,155,336(+) AGTCC(C/T)CAGTT downstream-variant-500B
rs1042164 - 13,153,584(+) GGACG(C/T)TGGAC reference, missense
rs1042165 -- 13,153,654(+) GAAGT(C/G)GCCGA reference, synonymous-codon
rs3174806 -- 13,154,827(+) TCGTG(C/T)GGTGG utr-variant-3-prime
rs3745992 -- 13,154,456(-) GGGCG(A/G)GTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IER2 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3737n71 CNV Loss 21882294

Relevant External Links for IER2 Gene

HapMap Linkage Disequilibrium report
IER2
Human Gene Mutation Database (HGMD)
IER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER2 Gene

Disorders for IER2 Gene

No disorders were found for IER2 Gene.

No data available for UniProtKB/Swiss-Prot for IER2 Gene

Publications for IER2 Gene

  1. Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PMID: 2061303) Shimizu N. … Utlyama H. (J. Biol. Chem. 1991) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T. … Gstaiger M. (Mol. Syst. Biol. 2009) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Functional analyses of immediate early gene ETR101 expressed in yeast. (PMID: 19584537) Takaya T. … Nikawa J. (Biosci. Biotechnol. Biochem. 2009) 3

Products for IER2 Gene

Sources for IER2 Gene

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