External Ids for IDUA Gene
Previous GeneCards Identifiers for IDUA Gene
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
GeneCards Summary for IDUA Gene
IDUA (Iduronidase, Alpha-L-) is a Protein Coding gene. Diseases associated with IDUA include Mucopolysaccharidosis Is and Mucopolysaccharidosis Ih/S. Among its related pathways are Defective B4GALT7 causes EDS, progeroid type and Lysosome. GO annotations related to this gene include receptor binding and L-iduronidase activity.