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IDUA Gene

protein-coding GIFtS: 62

GC04P000970

iduronidase, alpha-L-
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.2.1.76 ^³
IDA ^², ⁵
MPS1 ^¹, ²
alpha-L-iduronidase ^²

Descriptions
iduronidase, alpha-L- ^²

External Ids
HGNC: 5391¹
Entrez Gene: 3425²
UniProtKB: P35475³
Ensembl: ENSG00000127415⁷

Search outside databases for aliases for IDUA gene

Previous GC identifer: GC04P001023

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDUA:

This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two

glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the

lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic

deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided

by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IDUA gene

Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3

IDUA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P000970: (about GC identifiers)

Start:	970,785 bp from pter
End:	988,317 bp from pter
Size:	17,533 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_037622.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475 (See protein sequence)

Recommended Name: Alpha-L-iduronidase precursor

Size: 653 amino acids; 72670 Da

Subunit: Monomer (Probable)

Subcellular location: Lysosome

PDB structures from and Proteopedia :

1Y24 (3D)

REFSEQ proteins: NP_000194.2

ENSEMBL proteins:

ENSP00000247933

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IDUA (alpha-L-Iduronidase/IDUA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IEA	--

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Antibodies for IDUA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for IDUA (alpha-L-Iduronidase/IDUA)
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IDUA

Assays for IDUA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35475

ProtoNet protein and cluster: P35475

1 Blocks protein family: IPB000514 Glycoside hydrolase

UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475

Similarity: Belongs to the glycosyl hydrolase 39 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDUA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000203

Applied Biosystems Silencer® siRNAs for IDUA

Sigma-Aldrich siRNA and siRNA Panels for IDUA

Sigma-Aldrich shRNA for IDUA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000203
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000203
untagged cDNA clone in CMV expression vector: NM_000203

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000203

UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475

Catalytic activity: Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate

Enzyme Number (IUBMB): EC 3.2.1.76

Genatlas biochemistry entry for IDUA:

iduronidase,alpha-L,same as D4S111,lysosomal,hydrolyzing dermatan sulfate,heparan

sulfate,catalyzing the second step of degradation of glucosaminoglycans (mucopolysaccharides)

15/19 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Idua) (see all 19 ):

	behavior/neurological	cellular	craniofacial	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
limbs/digits/tail	liver/biliary system	muscle	nervous system	renal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003940	L-iduronidase activity	TAS	2470345
GO:0043169	cation binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for IDUA (Your Favorite Gene powered by Ingenuity)

Glycosaminoglycan Degradation

GeneDecks IDUA for the pathways selected above

About GeneDecksing

1 Interacting protein for IDUA (P35475²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
MPP3 Q13368² MINT-64783
About this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0005984 disaccharide metabolic process TAS 2470345
GO:0007040 lysosome organization IEA --
GO:0008152 metabolic process IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDUA
10/12 Novoseek chemical compound relationships for IDUA gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	77.86	18	15851016 (2), 11861306 (1), 7950365 (1), 1525210 (1) (see all 11)
heparan sulfate	74.26	21	8680403 (1), 9425437 (1), 11861306 (1), 12517274 (1) (see all 17)
mannose 6-phosphate	68.56	9	16439176 (2), 9425437 (1), 18838694 (1), 9068797 (1) (see all 7)
dermatan	64.24	1	1917344 (1)
mucopolysaccharide	58.88	3	9425437 (1), 1907534 (1)
iduronic acid	54.40	1	16283671 (1)
mannose	47.38	2	7950365 (1), 18613275 (1)
tetrasaccharide	44.75	1	14718373 (1)
ganglioside	10.04	2	2121405 (1), 16718701 (1)
sulfate	0.00	1	14718373 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDUA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000203

Sigma-Aldrich siRNA and siRNA Panels for IDUA

Sigma-Aldrich shRNA for IDUA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000203

REFSEQ mRNAs for IDUA gene:

NM_000203.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000203

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000203
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000203
                                 untagged cDNA clone in CMV expression vector: NM_000203

Additional cDNA sequence:

AK098805.1 AK291816.1 BC029959.1 BC099922.1 M74715.1

13 DOTS entries:

DT.100748479 DT.95211433 DT.100748478 DT.101982098 DT.312397 DT.97841748 DT.91740837 DT.95308638

DT.121268303 DT.121268400 DT.97816385 DT.99963606 DT.97833470

24/186 AceView cDNA sequences (see all 186 ):

AK098805 AI703058 AI739461 AW341134 BQ015011 BE551022 AI703146 W25580

BE674945 CB528887 AI767745 AI861925 BE045581 NM_000203 BE670003 BM887869

AI093301 BE675894 BM929869 AK125223 N92855 CD671947 M74715 AW572912

highest scoring ESTs for IDUA:

AA037258 AA114859 AA291558 AA291878 AA452571 AA452751 AA593967 AA902504 AA923385 AA970107

Unigene Cluster for IDUA:

Iduronidase, alpha-L-

Hs.89560 [show with all ESTs]

Unigene Representative Sequence: NM_000203

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDUA (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:									-		-						-		-		-
SP2:							-		-		-						-		-		-
SP3:											-						-		-		-
SP4:																	-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for IDUA

1 Ensembl transcript including schematic representation:

ENST00000247933

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDUA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDUA

¹ / ² / ³

5 probe-sets matching IDUA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33155_at²^{, 3}	U95-A	1	0.38	1.00	1.00	1.00	M95740	0.20	1.00	0.72	1
205059_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000203	0.60	1.00	0.82	1
205057_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI762782	0.60	1.00	0.82	1
205059_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205057_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCCCTCCC

SOURCE GeneReport for Unigene cluster: Hs.89560
Expression variation in blood from EXPOLDB for IDUA
UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDUA gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	IDUA¹	--	iduronidase, alpha-L-	85.08(n) 82.06(a)	511050 XM_872317.2 XP_877410.2
mouse (Mus musculus)	Idua^{1, 5}	5 (57.00 cM)⁵	iduronidase, alpha-L-^{1, 5}	79.96(n)¹ 78.96(a)¹	15932¹ NM_008325.2¹ NP_032351.1¹ AK031414⁵ AK045330⁵ (see all 13)
chicken (Gallus gallus)	IDUA¹	--	iduronidase, alpha-L-	60.77(n) 60.66(a)	427294 NM_001031433.1 NP_001026604.1
zebrafish (Danio rerio)	CH211-12E13.9¹	--	novel protein similar to vertebrate iduronidase, alpha-L-(IDUA)	62.45(n) 58.9(a)	567720 XM_001923654.1 XP_001923689.1
fruit fly (Drosophila melanogaster)	CG6201^{1, 3}	32D4³	L-iduronidase³ CG6201¹	30(a)³ 45.89(n)¹ 32.07(a)¹	34544¹ NM_135645.1¹ NP_609489.1¹

About this table Species with no ortholog for IDUA

ENSEMBL Gene Tree for IDUA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/81 NCBI SNPs in IDUA are shown (see all 81 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3755955^1,2	C,F,H	984414(-)	`GGCCCC/TGTCCA`	1	R/Q	mis¹ ese³		10		EA EU WA NA	2366
--	rs11934801^1,2	A,C	986555(+)	`AGGCCC/GGGACC`	1	G/R	mis¹ ese³		0	--	--	--	--
	rs6831280^1,2	C,F	986165(+)	`CCTTCA/GCGCAG`	1	A/T	mis¹		5		NA EU EA WA	444
	rs6830825^1,2	C,F	985919(+)	`AGGGCG/CGACGT`	1	A/A	syn¹ ese³		1		NA	52
	rs3755954^1,2	C,F	984452(-)	`GTCCAG/AGTACC`	1	L/L	syn¹ ese³		6		EA NA	1908
--	rs762586^1,2	F,H	988082(+)	`GTTCGG/AACCCT`	1	R/R	syn¹		5		EU EA WA MN	602
	rs6815946^1,2	C	985305(+)	`TGGAAC/TGAGCC`	1	N/N	syn¹		0	--	--	--	--
	rs1799846^1,2	A,C	982480(+)	`TCCACA/GTGGCC`	1	--	int¹		0	--	--	--	--
--	rs1814546^1,2	A,C	982763(-)	`CGCCCA/GCCTTG`	1	--	int¹		0	--	--	--	--
	rs10471250^1,2	A,C	979713(+)	`CTGAAC/TGCTCC`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IDUA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 252800 disorders: 607014 607016 607015

UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475

Defects in IDUA are the cause of mucopolysaccharidosis type 1H (MPS1H) [MIM:607014]; also

known as Hurler syndrome. MPS1H is a severe form of mucopolysaccharidosis type 1, a rare lysosomal

storage disease characterized by progressive physical deterioration with urinary excretion of

dermatan sulfate and heparan sulfate. Patients with MPS1H usually present, within the first year

of life, a combination of hepatosplenomegaly, skeletal deformities, corneal clouding and severe

mental retardation. Obstructive airways disease, respiratory infection and cardiac complications

usually result in death before 10 years of age

Defects in IDUA are the cause of mucopolysaccharidosis type 1H/S (MPS1H/S) [MIM:607015];

also known as Hurler-Scheie syndrome. MPS1H/S is a form of mucopolysaccharidosis type 1, a rare

lysosomal storage disease characterized by progressive physical deterioration with urinary

excretion of dermatan sulfate and heparan sulfate. MPS1H/S represents an intermediate phenotype of

the MPS1 clinical spectrum. It is characterized by relatively little neurological involvement, but

most of the somatic symptoms described for severe MPS1 develop in the early to mid-teens, causing

considerable loss of mobility

Defects in IDUA are the cause of mucopolysaccharidosis type 1S (MPS1S) [MIM:607016]; also

known as Scheie syndrome. MPS1S is a mild form of mucopolysaccharidosis type 1, a rare lysosomal

storage disease characterized by progressive physical deterioration with urinary excretion of

dermatan sulfate and heparan sulfate. Patients with MPS1S may have little or no neurological

involvement, normal stature and life span, but present development of joints stiffness, mild

hepatosplenomegaly, aortic valve disease and corneal clouding

10/26 Novoseek disease relationships for IDUA gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mucopolysaccharidosis type i	99.10	132	12517274 (3), 14718373 (3), 1339393 (2), 10870845 (2) (see all 86)
hurler-scheie syndrome	95.87	11	7550232 (2), 12517274 (1), 14559116 (1), 1832239 (1) (see all 8)
mucopolysaccharidosis	87.55	13	10735634 (2), 9425437 (1), 11110421 (1), 17718826 (1) (see all 9)
lysosomal storage diseases	82.87	15	17718826 (1), 18479957 (1), 1339393 (1), 9134434 (1) (see all 10)
enzyme deficiency	68.01	4	1907053 (1), 1909400 (1), 17490413 (1), 17920576 (1)
mucopolysaccharidosis type vii	51.43	2	9134434 (1), 8006122 (1)
deficiency diseases	48.19	2	7809150 (1), 7550232 (1)
pompe disease	39.48	2	16359666 (1)
cns diseases	38.49	2	15639191 (1)
hepatomegaly	38.01	1	16324679 (1)

About this table

GeneTests: IDUA

Mucopolysaccharidosis Type I

Human Gene Mutation Database: IDUA
Genetic Association Database: IDUA
Human Genome Epidemiology Navigator: IDUA (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

FDA Grants Orphan Drug Status To Recombinant Human Iduronidase For Mucopolysaccharidosis

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/182 PubMed articles for IDUA gene (see all 182 ):

Human alpha-L-iduronidase: cDNA isolation and expression. (PubMed id 1946389)^{1, 3, 4} Scott H.S.... Hopwood J.J. (1991)
Identification and molecular characterization of alpha-L-iduronidase mutations present in mucopolysaccharidosis type I patients undergoing enzyme replacement therapy. (PubMed id 15300847)^{1, 3, 4} Yogalingam G.... Hopwood J.J. (2004)
Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity. (PubMed id 10466419)^{1, 3, 4} Lee-Chen G.J.... Chin Y.W. (1999)
Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency. (PubMed id 8554071)^{1, 3, 4} Aronovich E.L.... Whitley C.B. (1996)
PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene. (PubMed id 1362562)^{1, 3, 4} Scott H.S.... Morris C.P. (1992)
Identification and characterization of -3c-g acceptor splice site mutation in human alpha-L-iduronidase associated with mucopolysaccharidosis type IH/S. (PubMed id 10735634)^{1, 3, 4} Teng Y.N.... Lee-Chen G.J. (2000)
Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene. (PubMed id 1832239)^{1, 2, 3} MacDonald M.E....Gusella J.F. (1991)
Four novel mutations underlying mild or intermediate forms of alpha- L-iduronidase deficiency (MPS IS and MPS IH/S). (PubMed id 7550232)^{1, 3, 4} Tieu P.T.... Neufeld E.F. (1995)
Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications. (PubMed id 8680403)^{1, 3, 4} Scott H.S.... Hopwood J.J. (1995)
Structure and sequence of the human alpha-L-iduronidase gene. (PubMed id 1505961)^{1, 3, 4} Scott H.S.... Morris C.P. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3425	HGNC: 5391	AceView: IDUA	Ensembl:ENSG00000127415	euGenes: HUgn3425
ECgene: IDUA	H-InvDB: IDUA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=IDUA

Licensable Technologies for IDUA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IDUA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDUA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDUA		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDUA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
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IDUA Gene at Home site.
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IDUA Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for IDUA

Summaries
for IDUA

Genomic Location
for IDUA

Proteins
for IDUA

Protein Domains/
Families
for IDUA

Gene Function
for IDUA

Pathways & Interactions
for IDUA

Drugs & Compounds
for IDUA

Transcripts
for IDUA

Expression
for IDUA

Orthologs
for IDUA

Paralogs
for IDUA

SNPs/Variants
for IDUA

Disorders & Mutations
for IDUA

Medical News
for IDUA

Publications
for IDUA

Search for IDUA

Genome Databases showing IDUA

Other Databases showing IDUA

Specialized Databases showing IDUA

Licensable Technologies
for IDUA

Services
for IDUA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDUA Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor IDUA

Summariesfor IDUA

Genomic Locationfor IDUA

Proteinsfor IDUA

Protein Domains/Familiesfor IDUA

Gene Functionfor IDUA

Pathways & Interactionsfor IDUA

Drugs & Compoundsfor IDUA

Transcriptsfor IDUA

Expression for IDUA

Orthologsfor IDUA

Paralogsfor IDUA

SNPs/Variantsfor IDUA

Disorders & Mutationsfor IDUA

Medical Newsfor IDUA

Publicationsfor IDUA

Search for IDUA

Genome Databases showing IDUA

Other Databases showing IDUA

Specialized Databases showing IDUA

Licensable Technologiesfor IDUA

Servicesfor IDUA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDUA

Summaries
for IDUA

Genomic Location
for IDUA

Proteins
for IDUA

Protein Domains/
Families
for IDUA

Gene Function
for IDUA

Pathways & Interactions
for IDUA

Drugs & Compounds
for IDUA

Transcripts
for IDUA

Expression
for IDUA

Orthologs
for IDUA

Paralogs
for IDUA

SNPs/Variants
for IDUA

Disorders & Mutations
for IDUA

Medical News
for IDUA

Publications
for IDUA

Licensable Technologies
for IDUA

Services
for IDUA