IDUA Gene
protein-coding GIFtS: 61
GCID: GC04P000970
|
|
iduronidase, alpha-L-
| |
Aliases
for IDUA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Iduronidase, Alpha-L-1 2 | | MPS11 2 | | IDA2 5 | | Alpha-L-Iduronidase1 | | EC 3.2.1.763 |
Export aliases for IDUA gene to outside databasesPrevious GC identifer: GC04P001023 |
Summaries
for IDUA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IDUA:
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans,dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of theseglycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive diseasemucopolysaccharidosis type I (MPS I). (provided by RefSeq, Jul 2008)
|
Genomic Views
for IDUA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IDUA gene promoter:
USF1 PPAR-gamma1 p53 USF-1 PPAR-gamma2 POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IDUA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDUA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3IDUA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P000970: view genomic region
(about GC identifiers)
Start:
|
980,785 bp from pter |
End:
|
998,317 bp from pter |
Size:
|
17,533 bases |
Orientation:
|
plus strand |
|
Proteins
for IDUA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475 (See
protein sequence)Recommended Name: Alpha-L-iduronidase precursor Size: 653 amino acids; 72670 Da
Subunit: Monomer (Probable)
Subcellular location: Lysosome
1 PDB 3D structure from  and Proteopedia  for IDUA:1Y24 (3D)
Explore the universe of human proteins at neXtProt for IDUA: NX_P35475
IDUA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000194.2
ENSEMBL proteins: ENSP00000247933 ENSP00000422952 ENSP00000424847 ENSP00000423685 ENSP00000424227 ENSP00000425081 ENSP00000396458 Reactome Protein details: P35475
Human Recombinant Protein Products for IDUA:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IDUA for ontologies About GeneDecksing
IDUA Antibody Products:
Assay Products for IDUA: |
Protein
Domains /
Families
for IDUA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IDUA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35475ProtoNet protein and cluster: P35475 1 Blocks protein family: IPB000514 Glycoside hydrolase
UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475Similarity: Belongs to the glycosyl hydrolase 39 family |
Function
for IDUA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IDUA_HUMAN, P35475Catalytic activity: Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate Genatlas biochemistry entry for IDUA:iduronidase,alpha-L,same as D4S111,lysosomal,hydrolyzing dermatan sulfate,heparan sulfate,catalyzing the second step ofdegradation of glucosaminoglycans (mucopolysaccharides)
Enzyme Number (IUBMB): EC 3.2.1.761
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003940 | L-iduronidase activity |
IEA | -- | | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
-- | -- | | GO:0005102 | receptor binding |
IEA | -- | | GO:0043169 | cation binding |
IEA | -- |
IDUA for ontologies About GeneDecksing
Phenotypes:
15/20 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Idua) (see all 20):
IDUA for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for IDUA: Iduatm1Clk Iduatm1Efn
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IDUA (NM_000203) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDUA | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IDUA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDUA |
|
Pathways & Interactions
for IDUA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | Metabolism | | | 3 | Disease | | | 4 | Lysosome | | | 5 | Glycosaminoglycan degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/20 
Reactome Pathways for IDUA (see all 20)
3 
Kegg Pathways (Kegg details for IDUA):
IDUA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IDUA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/25 Interacting proteins for IDUA (P354752, 3 ENSP000002479334) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
IDUA for ontologies About GeneDecksing
|
Drugs & Compounds
for IDUA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IDUA for compounds About GeneDecksing
 Browse Tocris compounds for IDUA
3 HMDB Compounds for IDUA About this table
10/25 Novoseek chemical compound relationships for IDUA gene (see all 25) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dermatan sulfate |
83.9 |
28 |
8680403 (1), 9425437 (1), 11861306 (1), 12517274 (1) (see all 21) |
| glycosaminoglycan |
78.2 |
22 |
15851016 (2), 19384290 (2), 11861306 (1), 7950365 (1) (see all 12) |
| idarubicin |
77.4 |
83 |
9147610 (8), 12028023 (6), 9256828 (5), 8057680 (5) (see all 15) |
| heparan sulfate |
74.4 |
26 |
8680403 (1), 9425437 (1), 11861306 (1), 12517274 (1) (see all 19) |
| dermatan |
69.2 |
4 |
19839758 (1), 1917344 (1) |
| mannose 6-phosphate |
67.4 |
9 |
16439176 (2), 9425437 (1), 18838694 (1), 9068797 (1) (see all 7) |
| mucopolysaccharide |
57.4 |
3 |
9425437 (1), 1907534 (1) |
| iduronic acid |
52.9 |
1 |
16283671 (1) |
| mannose |
45.5 |
2 |
7950365 (1), 18613275 (1) |
| tetrasaccharide |
43.2 |
1 |
14718373 (1) |
Search CenterWatch for drugs/clinical trials and news about IDUA
|
Transcripts
for IDUA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IDUA gene: NM_000203.3 Unigene Cluster for IDUA: Iduronidase, alpha-L- Hs.89560 [show with all ESTs]Unigene Representative Sequence: NM_00020313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000247933(uc003gby.3 uc003gbz.3) ENST00000502910 ENST00000514698
ENST00000508168 ENST00000506561 ENST00000504568 ENST00000509744 ENST00000514192
ENST00000509948 ENST00000514224 ENST00000502829 ENST00000514417 ENST00000453894(uc003gca.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IDUA (NM_000203) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDUA | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IDUA |
Additional cDNA sequence: AK098805.1 AK291816.1 BC029959.1 BC099922.1 M74715.1 13 DOTS entries: DT.100748479 DT.95211433 DT.100748478 DT.101982098 DT.312397 DT.97841748 DT.91740837 DT.95308638 DT.121268303 DT.121268400 DT.97816385 DT.99963606 DT.97833470 24/186 AceView cDNA sequences (see all 186): BE674945 AI093301 AI216475 NM_000203 AI809662 AW341134 CB049523 BM887869 W25580 AI911115 AI332855 AI457535 AI332567 AI703058 AI917596 BQ772031 AI703146 AI739461 BE327278 R69402 AI861925 BE045581 H27612 M74715
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDUA (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IDUA
|
Expression
for IDUA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IDUA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCCTCCC
About this image
See IDUA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IDUA
SOURCE GeneReport for Unigene cluster: Hs.89560
UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for IDUA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDUA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IDUA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDUA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDUA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDUA |
Orthologs
for IDUA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IDUA gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for IDUA (if available)
TreeFam Gene Tree for IDUA (if available) |
Paralogs
for IDUA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IDUA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IDUA (980785 - 998317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for IDUA
4 CNVs: 30190 30187 30189 30188
Human Gene Mutation Database (HGMD): IDUA
Locus Specific Mutation Databases (LSDB): IDUA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDUA |
|
Disorders
/ Diseases
for IDUA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IDUA for disorders About GeneDecksing
OMIM gene information: 252800
OMIM disorders: 607014 607016 607015
UniProtKB/Swiss-Prot: IDUA_HUMAN, P35475
Defects in IDUA are the cause of mucopolysaccharidosis type 1H (MPS1H) [MIM:607014]; also known as Hurlersyndrome. MPS1H is a severe form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized byprogressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1Husually present, within the first year of life, a combination of hepatosplenomegaly, skeletal deformities, cornealclouding and severe mental retardation. Obstructive airways disease, respiratory infection and cardiac complicationsusually result in death before 10 years of age Defects in IDUA are the cause of mucopolysaccharidosis type 1H/S (MPS1H/S) [MIM:607015]; also known asHurler-Scheie syndrome. MPS1H/S is a form of mucopolysaccharidosis type 1, a rare lysosomal storage diseasecharacterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate.MPS1H/S represents an intermediate phenotype of the MPS1 clinical spectrum. It is characterized by relatively littleneurological involvement, but most of the somatic symptoms described for severe MPS1 develop in the early tomid-teens, causing considerable loss of mobility Defects in IDUA are the cause of mucopolysaccharidosis type 1S (MPS1S) [MIM:607016]; also known as Scheiesyndrome. MPS1S is a mild form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized byprogressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1Smay have little or no neurological involvement, normal stature and life span, but present development of jointsstiffness, mild hepatosplenomegaly, aortic valve disease and corneal clouding
20/45  diseases for IDUA (see all 45): About MalaCardsmucopolysaccharidosis hurler-scheie syndrome autosomal recessive disease mucopolysaccharidosis ih
scheie syndrome mongolian spot lysosomal storage disease corneal clouding
duodenogastric reflux metachromatic leukodystrophy craniofacial abnormalities non-hodgkin lymphoma
hurler syndrome mucopolysaccharidosis i gaucher's disease metabolic disorders
friedreich ataxia leukodystrophy hodgkin's lymphoma leukopenia
1 disease from the University of Copenhagen DISEASES database for IDUA:Mucopolysaccharidosis 10/26 Novoseek disease relationships for IDUA gene (see all 26) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mucopolysaccharidosis type i |
99.1 |
149 |
12517274 (3), 14718373 (3), 1339393 (2), 10870845 (2) (see all 97) |
| hurler-scheie syndrome |
95.7 |
11 |
7550232 (2), 12517274 (1), 14559116 (1), 1832239 (1) (see all 8) |
| mucopolysaccharidosis |
88.7 |
13 |
10735634 (2), 9425437 (1), 11110421 (1), 17718826 (1) (see all 9) |
| lysosomal storage diseases |
82.4 |
18 |
17718826 (1), 18479957 (1), 1339393 (1), 9134434 (1) (see all 11) |
| enzyme deficiency |
66.9 |
4 |
1907053 (1), 1909400 (1), 17490413 (1), 17920576 (1) |
| mucopolysaccharidosis type vii |
50 |
2 |
9134434 (1), 8006122 (1) |
| deficiency diseases |
46.9 |
2 |
7809150 (1), 7550232 (1) |
| hepatomegaly |
45.6 |
1 |
16324679 (1) |
| pompe disease |
36.8 |
2 |
16359666 (1) |
| metabolic disorder |
36.2 |
1 |
11952079 (1) |
GeneTests: IDUA
Mucopolysaccharidosis Type I
Genetic Association Database (GAD): IDUA
Human Genome Epidemiology (HuGE) Navigator: IDUA (1 document)
Export disorders for IDUA gene to outside databases
|
Publications
for IDUA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IDUA gene, integrated from 9 sources (see all 212):
(articles sorted by number of sources associating them with IDUA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human alpha-L-iduronidase: cDNA isolation and expression. (PubMed id 1946389)1, 2, 9 Scott H.S.... Hopwood J.J. (1991)
- Identification and molecular characterization of alpha-L-iduronidase mutations present in mucopolysaccharidosis type I patients undergoing enzyme replacement therapy. (PubMed id 15300847)1, 2, 9 Yogalingam G.... Hopwood J.J. (2004)
- Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity. (PubMed id 10466419)1, 2, 9 Lee-Chen G.J.... Chin Y.W. (1999)
- Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency. (PubMed id 8554071)1, 2, 9 Aronovich E.L.... Whitley C.B. (1996)
- PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene. (PubMed id 1362562)1, 2, 9 Scott H.S.... Morris C.P. (1992)
- Identification and characterization of -3c-g acceptor splice site mutation in human alpha-L-iduronidase associated with mucopolysaccharidosis type IH/S. (PubMed id 10735634)1, 2, 9 Teng Y.N.... Lee-Chen G.J. (2000)
- Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene. (PubMed id 1832239)1, 3, 9 MacDonald M.E....Gusella J.F. (1991)
- Four novel mutations underlying mild or intermediate forms of alpha- L-iduronidase deficiency (MPS IS and MPS IH/S). (PubMed id 7550232)1, 2, 9 Tieu P.T.... Neufeld E.F. (1995)
- Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications. (PubMed id 8680403)1, 2, 9 Scott H.S.... Hopwood J.J. (1995)
- Structure and sequence of the human alpha-L-iduronidase gene. (PubMed id 1505961)1, 2, 9 Scott H.S.... Morris C.P. (1992)
|
External Searches for IDUA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IDUA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IDUA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IDUA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for IDUA | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IDUA |
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About This Section
| Patent Information for IDUA gene:
Search GeneIP for patents involving IDUA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IDUA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IDUA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDUA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDUA | | | OriGene Protein Over-expression Lysate for IDUA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IDUA | | OriGene 3'-UTR Clone for IDUA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDUA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IDUA | | OriGene Custom Protein Services for IDUA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IDUA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDUA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDUA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDUA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDUA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDUA |
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| | | | Search Tocris compounds for IDUA |
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 | | | IDUA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDUA |
|  |  |  |  | | | | ThermoFisher Antibody for IDUA |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IDUA |
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