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IDS Gene

protein-coding GIFtS: 65

GC0XM148369

iduronate 2-sulfatase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SIDS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.6.13 ^³
Idursulfase ^³
MPS2 ^², ⁵
OTTHUMP00000024207 ^²
OTTHUMP00000024210 ^²
S ^⁵
SIDS ^², ³
iduronate-2-sulfatase ^²
idursulfase ^²

Descriptions
Alpha-L-iduronate sulfate sulfatase ^², ³
iduronate 2-sulfatase ^²
iduronate 2-sulfatase 14 kDa chain ^²
iduronate 2-sulfatase 42 kDa chain ^²

External Ids
HGNC: 5389¹
Entrez Gene: 3423²
UniProtKB: P22304³
Ensembl: ENSG00000010404⁷

Search outside databases for aliases for IDS gene

Previous GC identifers: GC0XM143088 GC0XM145395 GC0XM146459 GC0XM147269 GC0XM148266

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDS:

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan

sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the

sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has

a strong sequence homology with human arylsulfatases A, B, and C, and human

glucosamine-6-sulfatase. A splice variant of this gene has been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304

Function: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate

Gene Wiki entry for IDS (Iduronate-2-sulfatase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IDS gene

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq27.3-q28

IDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM148369: (about GC identifiers)

Start:	148,368,206 bp from pter
End:	148,394,714 bp from pter
Size:	26,509 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011681.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IDS_HUMAN, P22304 (See protein sequence)

Recommended Name: Iduronate 2-sulfatase precursor

Size: 550 amino acids; 61873 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Subunit: Liver iduronate 2-sulfatase is composed of two major forms (A and B) which contain both a

42 kDa and a 14 kDa polypeptides

Subcellular location: Lysosome

Secondary accessions: Q14604

Alternative splicing: 2 isoforms: P22304-1 P22304-2

Post-translational modifications:

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine

residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity

(By similarity)¹

REFSEQ proteins (2 alternative transcripts):

NP_000193.1 NP_006114.1

ENSEMBL proteins:

ENSP00000339801 ENSP00000359470 ENSP00000359472 ENSP00000359467

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IDS (Iduronate 2-Sulfatase/IDS)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Iduronate 2 sulfatase)
	Human Recombinant Proteins from Abnova (IDS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IEA	--

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Antibodies for IDS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for IDS (Iduronate 2-Sulfatase/IDS)
	Antibodies from Abcam (Iduronate 2 sulfatase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IDS)
	Novus Biologicals Antibodies for IDS

Assays for IDS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22304

ProtoNet protein and cluster: P22304

1 Blocks protein family: IPB000917 Sulfatase

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304

Similarity: Belongs to the sulfatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000202

Applied Biosystems Silencer® siRNAs for IDS

Sigma-Aldrich siRNA and siRNA Panels for IDS

Sigma-Aldrich shRNA for IDS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IDS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000202
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000202
untagged cDNA clones in CMV expression vector (see all 4): AF050145

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000202

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304

Function: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate

Catalytic activity: Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of

dermatan sulfate, heparan sulfate and heparin

Enzyme Number (IUBMB): EC 3.1.6.13

Genatlas biochemistry entry for IDS:

iduronate 2-sulfatase,lysosomal,acting on dermatan sulfate,heparan sulfate,catalyzing the first

step of degradation of glucosaminoglycans (mucopolysaccharides)

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ids):

behavior/neurological	cellular	craniofacial	growth/size	immune system
life span-post-weaning/aging	limbs/digits/tail	nervous system	skeleton	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004423	iduronate-2-sulfatase activity	TAS	2122463
GO:0005509	calcium ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for IDS (Your Favorite Gene powered by Ingenuity)

Glycosaminoglycan Degradation

GeneDecks IDS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IDS

4 Interacting proteins for IDS (ENSP00000339801³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HPSE	ENSP00000308107³	STRING (score=.916)
HPSE2	ENSP00000359583³	STRING (score=.899)
AFF2	ENSP00000286437³	STRING (score=.771)
--	ENSP00000372436³	STRING (score=.969)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--
GO:0030203	glycosaminoglycan metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDS
9 Novoseek chemical compound relationships for IDS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iduronate 2-sulphate	81.85	3	16022372 (2)
dermatan	72.34	2	15966019 (1), 8325651 (1)
heparan sulfate	70.10	13	15966019 (1), 7663435 (1), 8325651 (1), 8244397 (1) (see all 10)
iduronic acid	57.06	3	7663435 (1), 8325651 (1)
mucopolysaccharide	51.64	1	9375851 (1)
hind iii	45.58	3	8370574 (1), 1352274 (1)
glycosaminoglycan	37.78	1	8870917 (1)
sulfate	9.31	3	7663435 (1), 8325651 (1)
steroid	0.00	3	11315200 (1), 17064891 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000202

Sigma-Aldrich siRNA and siRNA Panels for IDS

Sigma-Aldrich shRNA for IDS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000202 NM_006123

REFSEQ mRNAs for IDS gene (2 alternative transcripts):

NM_000202.4 NM_006123.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000202 NM_006123

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000202
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000202
                                 untagged cDNA clones in CMV expression vector (see all 4): AF050145

Additional cDNA sequence:

AF050144.1 AF179280.1 AF179281.1 AK055600.1 AK057191.1 AK124660.1 AK294541.1 AK295815.1

AL049247.1 AL117536.1 BC006170.1 BX647357.1 CR625022.1 EF363095.1 L40586.1 M58342.1

U66044.1 U66045.1 U66055.1

24/45 DOTS entries (see all 45 ):

DT.448912 DT.95214772 DT.100812442 DT.95200577 DT.101957016 DT.100038327 DT.121299290 DT.75185698

DT.101961952 DT.121299157 DT.101977157 DT.97801656 DT.121643349 DT.91857589 DT.121643182 DT.86847177

DT.95326972 DT.121299130 DT.308816 DT.439576 DT.440153 DT.121299119 DT.121299190 DT.121640339

24/471 AceView cDNA sequences (see all 471 ):

BU625704 AL119592 CB155568 R87373 AA586715 AA460523 AA701678 AI419348

BF222034 AU138163 BU857935 BM968830 BC006170 AW612237 CF593282 BU182909

AA319199 BU538376 BE385802 BU955851 F05595 CB960647 U66052 CK821982

highest scoring ESTs for IDS:

AF050145 L40586 AA010835 AA513794 AA776101 AA873599 AA993642 AI042325 AI089762 AI096538

Unigene Cluster for IDS:

Iduronate 2-sulfatase

Hs.460960 [show with all ESTs]

Unigene Representative Sequence: NM_000202

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDS (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b
SP1:													-		-				-		-
SP2:													-		-
SP3:																			-		-																		-
SP4:																			-		-																		-
SP5:																																							-		-		-

About this scheme

ECgene alternative splicing isoforms for IDS

4 Ensembl transcripts including schematic representations:

ENST00000340855 ENST00000370441 ENST00000370443 ENST00000370438

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDS

¹ / ² / ³

22 probe-sets matching IDS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40592_at²^{, 3}	U95-A	1	1.00	1.00	0.80	0.84	L13329	0.20	1.00	0.72	1
40814_at²^{, 3}	U95-A	1	1.00	1.00	0.35	0.72	L40586	1.00	1.00	1.00	1
63459_at²^{, 3}	U95-C	1	1.00	1.00	0.92	1.11	R36029	0.40	1.00	0.76	1
40815_g_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.19	L40586	1.00	1.00	1.00	1
39451_i_at²^{, 3}	U95-A	2	1.00	0.90	-0.29	1.27	AF050145	1.00	1.00	1.00	1
39450_s_at²^{, 3}	U95-A	3	1.00	0.79	-0.15	0.90	AF050145	1.00	1.00	1.00	1
210666_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF050145	1.00	1.00	1.00	1
202438_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF346014	0.40	1.00	0.76	1
211782_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006170	0.80	1.00	0.91	1
206342_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006123	0.60	1.00	0.82	1
217432_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF179281	0.60	0.83	0.73	1
202439_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000202	0.40	1.00	0.76	1
212223_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AI926544	0.40	1.00	0.76	1
212221_x_at²^{, 3}	U133-A	2	1.00	0.55	--	--	AV703259	0.20	1.00	0.72	1
210666_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202438_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211782_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206342_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217432_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202439_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212223_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
212221_x_at²	U133Plus2	2	1.00	0.55	--	--	--	--	--	--	--

GeneDecks IDS for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTCTCTTTG

SOURCE GeneReport for Unigene cluster: Hs.460960
Expression variation in blood from EXPOLDB for IDS
UniProtKB/Swiss-Prot: IDS_HUMAN, P22304
Tissue specificity: Liver, kidney, lung, and placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDS gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IDS¹	--	iduronate 2-sulfatase	86.34(n) 87.87(a)	492194 XM_549314.2 XP_549314.2
chimpanzee (Pan troglodytes)	IDS¹	--	iduronate 2-sulfatase	85.63(n) 81.44(a)	465896 XM_521297.2 XP_521297.2
cow (Bos taurus)	IDS¹	--	iduronate 2-sulfatase	85.5(n) 86.29(a)	541272 XM_615420.3 XP_615420.3
rat (Rattus norvegicus)	Ids¹	--	iduronate 2-sulfatase	82.03(n) 81.9(a)	363513 XM_579042.2 XP_579042.2
mouse (Mus musculus)	Ids^{1, 5}	X (27.00 cM)⁵	iduronate 2-sulfatase^{1, 5}	84.31(n)¹ 86.13(a)¹	15931¹ NM_010498.2¹ NP_034628.2¹ AF538870⁵ AJ627044⁵ (see all 15)

About this table Species with no ortholog for IDS

ENSEMBL Gene Tree for IDS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IDS gene

ENSG00000176289²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/127 NCBI SNPs in IDS are shown (see all 127 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs725679^1,2	A,C,F,H,O	148376196(+)	`AGATGT/CTCAGA`	2	--	int¹ ng5¹		6		EA WA NA	396
	rs8965^1,2	A,C,F,H,O	148369237(+)	`AATTTC/TGTGGT`	1	--	ut3¹ ese³		10		EU EA WA NA	787
	rs11969^1,2	A,C,F,H	148369179(+)	`TATGAT/CCAGAA`	1	--	ut3¹		4		EU EA WA	414
	rs2075546^1,2	A,C,F,H	148376177(+)	`TCCCCG/ACCCAG`	2	--	ng5¹ int¹		5		EA WA NA	480
	rs4844025^1,2	A,C,F,H	148371055(+)	`ATGAGC/TTGTAA`	1	--	ut3¹ ese³		12		EU EA WA NA	904
	rs624769^1,2	A,C,F,H	148396101(+)	`TAGCAA/TTTTAG`	2	--	ng3¹		4		EU EA WA	418
	rs525912^1,2	A,C,F,H	148396176(+)	`TCGCTG/ATCCCC`	2	--	ng3¹		4		EU EA WA	418
	rs1064463^1,2	C,F,H	148370504(-)	`TTTATT/CGCCTG`	1	--	ut3¹		8		MN EU EA WA NA	702
--	rs5936291^1,2	A,C	148368517(+)	`gtggcA/Gcgatc`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs17252662^1,2	F,H	148370526(+)	`TGAACT/GATGTC`	1	--	ut3¹		7		NA EU EA WA	535

About this table

HapMap Linkage Disequilibrium images for IDS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 309900

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304

Defects in IDS are the cause of mucopolysaccharidosis type 2 (MPS2) [MIM:309900]; also

known as Hunter syndrome. MPS2 is an X-linked lysosomal storage disease characterized by

intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine.

Most children with MPS2 have a severe form with early somatic abnormalities including skeletal

deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent

feature is neurological damage that presents as developmental delay and hyperactivity but

progresses to mental retardation and dementia. They die before 15 years of age, usually as a

result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of

MPS2 may survive into adulthood, with attenuated somatic complications and often without mental

retardation

8 Novoseek disease relationships for IDS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hunters syndrome	98.91	203	17345556 (4), 1901826 (3), 8835216 (3), 18201153 (3) (see all 89)
sudden infant death syndrome	80.38	19	2007878 (1), 8198848 (1), 15960133 (1), 8185361 (1) (see all 17)
mucopolysaccharidosis	79.01	8	8103756 (1), 15146464 (1), 17284421 (1), 1303177 (1) (see all 6)
lysosomal storage diseases	77.60	10	17217652 (1), 9337875 (1), 16480701 (1), 18331837 (1) (see all 8)
asphyxia	24.24	3	12638728 (1), 1474151 (1)
mental retardation	23.79	1	17506108 (1)
leukemia	0.00	2	8835216 (1), 10808215 (1)
genetic disorder	0.00	2	1464193 (1)

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GeneTests: IDS

Mucopolysaccharidosis Type II

Human Gene Mutation Database: IDS

(Possibly Related Articles in Doctor's Guide)
About This Section

Wellbutrin XL (Bupropion Extended-Release Formulation) Effective for Treatment of Major Depression

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/176 PubMed articles for IDS gene (see all 176 ):

Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA. (PubMed id 2122463)^{1, 3, 4} Wilson P.J.... Hopwood J.J. (1990)
Sequence of the human iduronate 2-sulfatase (IDS) gene. (PubMed id 8244397)^{1, 3, 4} Wilson P.J.... Morris C.P. (1993)
Identification of an alternative transcript from the human iduronate- 2-sulfatase (IDS) gene. (PubMed id 8530090)^{1, 3, 4} Malmgren H.... Bondeson M.L. (1995)
Mutations of the iduronate-2-sulfatase (IDS) gene in patients with Hunter syndrome (mucopolysaccharidosis II). (PubMed id 7981716)^{1, 3, 4} Schroeder W.... Herrmann F.H. (1994)
Molecular basis of iduronate-2-sulphatase gene mutations in patients with mucopolysaccharidosis type II (Hunter syndrome). (PubMed id 9950361)^{1, 3, 4} Li P.... Thompson J.N. (1999)
Mutational spectrum of the iduronate-2-sulfatase (IDS) gene in 36 unrelated Russian MPS II patients. (PubMed id 9921913)^{1, 3, 4} Karsten S.... Bondeson M.-L. (1998)
Molecular diagnosis of mucopolysaccharidosis type II (Hunter syndrome) by automated sequencing and computer-assisted interpretation: toward mutation mapping of the iduronate-2-sulfatase gene. (PubMed id 7887413)^{1, 3, 4} Jonsson J.J.... Whitley C.B. (1995)
The effect of four mutations on the expression of iduronate-2- sulfatase in mucopolysaccharidosis type II. (PubMed id 11731225)^{1, 3, 4} Bonuccelli G....Filocamo M. (2001)
Expression of five iduronate-2-sulfatase site-directed mutations. (PubMed id 10838181)^{1, 3, 4} Villani G.R.D.... Di Natale P. (2000)
Identification of 9 novel gene mutations in 19 unrelated Hunter syndrome (Mucopolysaccharidosis type II) patients. (PubMed id 10671065)^{1, 3, 4} Karsten S.L.... Bondeson M.-L. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3423	HGNC: 5389	AceView: IDS	Ensembl:ENSG00000010404	euGenes: HUgn3423
ECgene: IDS	H-InvDB: IDS

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=IDS

Licensable Technologies for IDS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IDS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDS		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IDS)
	Antibodies (IDS)
	Chimera RNAi (IDS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Iduronate 2 sulfatase)
	Antibodies (Iduronate 2 sulfatase)

Search OriGene for IDS

Search Tocris compounds for IDS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IDS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IDS Gene at Home site.
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IDS Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for IDS

Summaries
for IDS

Genomic Location
for IDS

Proteins
for IDS

Protein Domains/
Families
for IDS

Gene Function
for IDS

Pathways & Interactions
for IDS

Drugs & Compounds
for IDS

Transcripts
for IDS

Expression
for IDS

Orthologs
for IDS

Paralogs
for IDS

SNPs/Variants
for IDS

Disorders & Mutations
for IDS

Medical News
for IDS

Publications
for IDS

Search for IDS

Genome Databases showing IDS

Other Databases showing IDS

Specialized Databases showing IDS

Licensable Technologies
for IDS

Services
for IDS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDS Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor IDS

Summariesfor IDS

Genomic Locationfor IDS

Proteinsfor IDS

Protein Domains/Familiesfor IDS

Gene Functionfor IDS

Pathways & Interactionsfor IDS

Drugs & Compoundsfor IDS

Transcriptsfor IDS

Expression for IDS

Orthologsfor IDS

Paralogsfor IDS

SNPs/Variantsfor IDS

Disorders & Mutationsfor IDS

Medical Newsfor IDS

Publicationsfor IDS

Search for IDS

Genome Databases showing IDS

Other Databases showing IDS

Specialized Databases showing IDS

Licensable Technologiesfor IDS

Servicesfor IDS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDS

Summaries
for IDS

Genomic Location
for IDS

Proteins
for IDS

Protein Domains/
Families
for IDS

Gene Function
for IDS

Pathways & Interactions
for IDS

Drugs & Compounds
for IDS

Transcripts
for IDS

Expression
for IDS

Orthologs
for IDS

Paralogs
for IDS

SNPs/Variants
for IDS

Disorders & Mutations
for IDS

Medical News
for IDS

Publications
for IDS

Licensable Technologies
for IDS

Services
for IDS