Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IDS Gene

protein-coding   GIFtS: 70
GCID: GC0XM148558

Iduronate 2-Sulfatase


(Previous symbol: SIDS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Iduronate 2-Sulfatase1 2     Iduronate 2-Sulfatase 42 KDa Chain2
SIDS1 2 3     idursulfase2
Alpha-L-Iduronate Sulfate Sulfatase2 3     EC 3.1.6.133
MPS22 5     Idursulfase3
Hunter Syndrome1     S5
Iduronate 2-Sulfatase 14 KDa Chain2     

External Ids:    HGNC: 53891   Entrez Gene: 34232   Ensembl: ENSG000000104047   OMIM: 3008235   UniProtKB: P223043   

Export aliases for IDS gene to outside databases

Previous GC identifers: GC0XM143088 GC0XM145395 GC0XM146459 GC0XM147269 GC0XM148266 GC0XM148369 GC0XM137513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDS Gene:
The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in
lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the
X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively
spliced transcript variants have been described for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for IDS Gene: 
IDS (iduronate 2-sulfatase) is a protein-coding gene. Diseases associated with IDS include mucopolysaccharidosis ii, and shaken baby syndrome, and among its related super-pathways are Metabolic pathways and Metabolism of carbohydrates. GO annotations related to this gene include iduronate-2-sulfatase activity and metal ion binding. An important paralog of this gene is ARSK.

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304
Function: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate

Gene Wiki entry for IDS (Iduronate-2-sulfatase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011681.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IDS gene promoter:
         NF-1/L   NF-1   S8   AP-1   HTF   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IDS promoter sequence
   Search SABiosciences Chromatin IP Primers for IDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq27.3-q28

IDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDS gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM148558:  view genomic region     (about GC identifiers)

Start:
148,558,521 bp from pter      End:
148,615,470 bp from pter
Size:
56,950 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IDS_HUMAN, P22304 (See protein sequence)
Recommended Name: Iduronate 2-sulfatase precursor  
Size: 550 amino acids; 61873 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Liver iduronate 2-sulfatase is composed of two major forms (A and B) which contain both a 42 kDa and a 14
kDa polypeptides
Subcellular location: Lysosome
Secondary accessions: D3DWT4 Q14604 Q9BRM3
Alternative splicing: 3 isoforms:  P22304-1   P22304-2   P22304-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IDS: NX_P22304

Explore proteomics data for IDS at MOPED 

Post-translational modifications:

  • UniProtKB: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22304

  • IDS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IDS Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000193.1  NP_001160022.1  NP_006114.1  

    ENSEMBL proteins: 
     ENSP00000339801   ENSP00000418264   ENSP00000359470   ENSP00000428980   ENSP00000390241  
     ENSP00000429745   ENSP00000441261   ENSP00000440324   ENSP00000359472  
    Reactome Protein details: P22304
    Human Recombinant Protein Products for IDS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IDS (Iduronate 2-Sulfatase/IDS)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IDS
    OriGene Protein Over-expression Lysate for IDS
    OriGene MassSpec for IDS 
    OriGene Custom Protein Services for IDS
    GenScript Custom Purified and Recombinant Proteins Services for IDS
    Novus Biologicals IDS Proteins
    Novus Biologicals IDS Lysates
    Sino Biological Recombinant Protein for IDS
    Sino Biological Cell Lysate for IDS 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IDS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043202lysosomal lumen TAS--

    IDS for ontologies           About GeneDecksing



    IDS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IDS (Iduronate 2-Sulfatase/IDS)
    OriGene Antibodies for IDS
    OriGene Custom Antibody Services for IDS
    GenScript Superior Antibodies for IDS
    Novus Biologicals IDS Antibodies
    Abcam antibodies for IDS
    Cloud-Clone Corp. Antibodies for IDS 
    ThermoFisher Antibodies for IDS
    LSBio Antibodies in human, mouse, rat for IDS 

    Assay Products for IDS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IDS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IDS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IDS 
    Cloud-Clone Corp. CLIAs for IDS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR000917 Sulfatase
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry P22304

    ProtoNet protein and cluster: P22304

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: IDS_HUMAN, P22304
    Similarity: Belongs to the sulfatase family


    IDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDS_HUMAN, P22304
    Function: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate
    Catalytic activity: Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate,
    heparan sulfate and heparin

         Genatlas biochemistry entry for IDS:
    iduronate 2-sulfatase,lysosomal,acting on dermatan sulfate,heparan sulfate,catalyzing the first step of
    degradation of glucosaminoglycans (mucopolysaccharides)

         Enzyme Number (IUBMB): EC 3.1.6.131

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004423iduronate-2-sulfatase activity TAS--
    GO:0005515protein binding ----
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    IDS for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IDS:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ids):
     behavior/neurological  cellular  craniofacial  growth/size  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton  vision/eye 

    IDS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Idstm1Muen for IDS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IDS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IDS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IDS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IDS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDS
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IDS (see all 9):
    hsa-miR-345 hsa-miR-1321 hsa-miR-429 hsa-miR-767-3p hsa-miR-513a-3p hsa-miR-7 hsa-miR-200c hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidIDS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IDS
    Sirion Biotech Customized adenovirus for overexpression of IDS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IDS (see all 18)
    OriGene ORF clones in mouse, rat for IDS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IDS (NM_001166550)
    Sino Biological Human cDNA Clone for IDS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDS
    Sirion Biotech Customized lentivirus for stable overexpression of IDS 
                         Customized lentivirus expression plasmids for stable overexpression of IDS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IDS
    Search LifeMap BioReagents cell lines for IDS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IDS About   (see all 8)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG degradation0.40
    4A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    5CS/DS degradation
    CS/DS degradation0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/20        Reactome Pathways for IDS (see all 20)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    3         Kegg Pathways  (Kegg details for IDS):
        Glycosaminoglycan degradation
    Metabolic pathways
    Lysosome


    IDS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for IDS (P223042, 3 ENSP000003398014) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSP011003, ENSP000003062454I2D: score=1 STRING: ENSP00000306245
    ARSBENSP000002649144STRING: ENSP00000264914
    HEXAENSP000002680974STRING: ENSP00000268097
    HPSEENSP000003081074STRING: ENSP00000308107
    IDUAENSP000002479334STRING: ENSP00000247933
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--

    IDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IDS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IDS

    5 HMDB Compounds for IDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Heparan sulfateHHS 5 (see all 13)9050-30-0--
    SulfateSulfate (ion 2-) (see all 9)14808-79-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/11 Novoseek inferred chemical compound relationships for IDS gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iduronate 2-sulfate 81.1 3 16022372 (2)
    dermatan sulfate 75.6 13 7663435 (1), 19602578 (1), 8244397 (1), 15500445 (1) (see all 9)
    dermatan 71.1 2 15966019 (1), 8325651 (1)
    heparan sulfate 70.6 14 15966019 (1), 7663435 (1), 19602578 (1), 8325651 (1) (see all 11)
    iduronic acid 55.4 3 7663435 (1), 8325651 (1)
    glycosaminoglycan 51.5 1 8870917 (1)
    mucopolysaccharide 49.7 1 9375851 (1)
    hind iii 44 3 8370574 (1), 1352274 (1)
    sulfate 6.5 3 7663435 (1), 8325651 (1)
    steroid 0 3 11315200 (1), 17064891 (1)

    Search CenterWatch for drugs/clinical trials and news about IDS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IDS gene (3 alternative transcripts): 
    NM_000202.6  NM_001166550.2  NM_006123.4  

    Unigene Cluster for IDS:

    Iduronate 2-sulfatase
    Hs.460960  [show with all ESTs]
    Unigene Representative Sequence: NM_000202
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340855(uc011mxd.2 uc011mxe.2 uc011mxf.2 uc011mxg.2 uc010nsu.2 uc004fcw.4)
    ENST00000466323(uc011mxi.2) ENST00000370441(uc011mxh.2) ENST00000490775
    ENST00000464251 ENST00000466019 ENST00000428056(uc011mxj.2) ENST00000521702
    ENST00000541269 ENST00000537071 ENST00000370443
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDS
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IDS (see all 9):
    hsa-miR-345 hsa-miR-1321 hsa-miR-429 hsa-miR-767-3p hsa-miR-513a-3p hsa-miR-7 hsa-miR-200c hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidIDS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDS
    Clone
    Products:
         
    OriGene clones in human, mouse for IDS (see all 18)
    OriGene ORF clones in mouse, rat for IDS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IDS (NM_001166550)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDS
    Sirion Biotech Customized lentivirus for stable overexpression of IDS 
                         Customized lentivirus expression plasmids for stable overexpression of IDS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IDS
    OriGene qSTAR qPCR primer pairs in human, mouse for IDS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IDS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDS

    Additional mRNA sequence: 

    AK055600.1 AK057191.1 AK294541.1 AK295815.1 AL049247.1 AL117536.1 BC006170.1 BX647357.1 
    EF363095.1 L40586.1 M58342.1 U66055.1 

    24/35 DOTS entries (see all 35):

    DT.448912  DT.95214772  DT.100812442  DT.95200577  DT.101957016  DT.100038327  DT.121299290  DT.75185698 
    DT.101961952  DT.121299157  DT.91857589  DT.121643182  DT.86847177  DT.95326972  DT.440153  DT.121299119 
    DT.121640339  DT.95180971  DT.95237864  DT.95367609  DT.95367613  DT.121299195  DT.75159376  DT.95200572 

    24/471 AceView cDNA sequences (see all 471):

    BI031683 AK124040 BM905195 W02397 BU625704 BU188264 AW592897 BU179706 
    AI096538 U66052 AA586714 BU538376 BE409348 BU179323 BU785472 F05594 
    AF179280 AL119592 BX953014 AK124660 CK821982 AW341942 BU158088 BI031684 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                      -     -           -     -                                                                                 
    SP2:                                      -     -                                                                                                   
    SP3:                                                        -     -                                                     -                           
    SP4:                                                        -     -                                                     -                           
    SP5:                                                                                                                    -     -     -               


    ECgene alternative splicing isoforms for IDS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IDS expression in normal human tissues (normalized intensities)      IDS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTCTTTG
    IDS Expression
    About this image


    IDS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Amygdala
             Globus Pallidus   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Peripheral blood-derived hematopoietic stem cells
             neutrophils   
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot

    See IDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IDS

    SOURCE GeneReport for Unigene cluster: Hs.460960

    UniProtKB/Swiss-Prot: IDS_HUMAN, P22304
    Tissue specificity: Liver, kidney, lung, and placenta

        SABiosciences Custom PCR Arrays for IDS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IDS
    OriGene qSTAR qPCR primer pairs in human, mouse for IDS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IDS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IDS gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ids1 , 5 iduronate 2-sulfatase1, 5 84.31(n)1
    86.13(a)1
      X (36.01 cM)5
    159311  NM_010498.31  NP_034628.21 
     703430695 
    chicken
    (Gallus gallus)
    Aves IDS1 iduronate 2-sulfatase 69.78(n)
    70.04(a)
      422392  XM_420361.3  XP_420361.3 
    lizard
    (Anolis carolinensis)
    Reptilia IDS6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343310.1(1085433-1094480)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195402 Transcribed sequence with moderate similarity to protein more 72.39(n)    AL886751.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ids1 iduronate 2-sulfatase 62.75(n)
    63.94(a)
      559959  NM_001080574.1  NP_001074043.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120141 , 3 iduronate-2-sulfatase3
    CG120141
    44(a)3
    52.22(n)1
    48.84(a)1
      63D23
    384231  NM_139557.21  NP_647814.11 


    ENSEMBL Gene Tree for IDS (if available)
    TreeFam Gene Tree for IDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IDS gene
    ARSK2  
    9 SIMAP similar genes for IDS using alignment to 8 protein entries:     IDS_HUMAN (see all proteins):
    SGSH    STS    ARSB    ARSH    ARSE    ARSF
    ARSJ    ARSI    DKFZp686G12235

    IDS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IDS
    PGOHUM00000242070


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/627 SNPs in IDS are shown (see all 627)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0073234
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0073232 S N mis40--------
    VAR_0269614
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0269612 Y S mis40--------
    VAR_0073724
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0073722 C G mis40--------
    VAR_0073614
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0073612 W R mis40--------
    VAR_0269284
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0269282 Q H mis40--------
    VAR_0073134
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0073132 D N mis40--------
    VAR_0269514
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0269512 G R mis40--------
    VAR_0073844
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0073842 W C mis40--------
    VAR_0269314
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0269312 G V mis40--------
    VAR_0081344
    Mucopolysaccharidosis 2 (MPS2)4--see VAR_0081342 E K mis40--------

    HapMap Linkage Disequilibrium report for IDS (148558521 - 148615470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IDS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7147CNV Insertion18451855
    esv33821CNV Loss17666407
    nsv525908CNV Gain19592680
    nsv518742CNV Gain19592680


    Human Gene Mutation Database (HGMD): IDS

    Locus Specific Mutation Databases (LSDB): IDS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IDS
    DNA2.0 Custom Variant and Variant Library Synthesis for IDS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300823   
    OMIM disorders: 309900  
    UniProtKB/Swiss-Prot: IDS_HUMAN, P22304
  • Mucopolysaccharidosis 2 (MPS2) [MIM:309900]: An X-linked lysosomal storage disease characterized by
    intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children
    with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly,
    and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as
    developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years
    of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form
    of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20 diseases for IDS:    About MalaCards
    mucopolysaccharidosis ii    shaken baby syndrome    mucopolysaccharidosis type 2b    tolosa-hunt syndrome
    mucopolysaccharidosis type 2a    tricuspid valve prolapse    mucopolysaccharidosis    mevalonic aciduria
    tracheal stenosis    sudden infant death syndrome    x-linked disease    pyoderma
    pyoderma gangrenosum    lysosomal storage disease    chorea    morquio syndrome b
    familial mediterranean fever    mental retardation    dementia    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for IDS:
    Mucopolysaccharidosis     Tracheal stenosis     tolosa-hunt syndrome     X-linked disease

    IDS for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for IDS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hunters syndrome 98.9 219 17345556 (4), 1901826 (3), 8835216 (3), 18201153 (3) (see all 96)
    mucopolysaccharidosis 82.1 9 8103756 (1), 15146464 (1), 17284421 (1), 1303177 (1) (see all 7)
    sudden infant death syndrome 80.4 20 2007878 (1), 8198848 (1), 15960133 (1), 8185361 (1) (see all 18)
    lysosomal storage diseases 78.3 10 17217652 (1), 9337875 (1), 16480701 (1), 18331837 (1) (see all 8)
    asphyxia 21.9 3 12638728 (1), 1474151 (1)
    mental retardation 21.3 1 17506108 (1)
    leukemia 0 2 8835216 (1), 10808215 (1)
    genetic disorder 0 2 1464193 (1)

    GeneTests: IDS
    GeneReviews: IDS
    Genetic Association Database (GAD): IDS
    Human Genome Epidemiology (HuGE) Navigator: IDS (8 documents)

    Export disorders for IDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IDS gene, integrated from 9 sources (see all 206):
    (articles sorted by number of sources associating them with IDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA. (PubMed id 2122463)1, 2, 9 Wilson P.J.... Hopwood J.J. (1990)
    2. Sequence of the human iduronate 2-sulfatase (IDS) gene. (PubMed id 8244397)1, 2, 9 Wilson P.J.... Morris C.P. (1993)
    3. Identification of an alternative transcript from the human iduronate- 2-sulfatase (IDS) gene. (PubMed id 8530090)1, 2, 9 Malmgren H.... Bondeson M.L. (1995)
    4. Mutations of the iduronate-2-sulfatase (IDS) gene in patients with Hunter syndrome (mucopolysaccharidosis II). (PubMed id 7981716)1, 2, 9 Schroeder W.... Herrmann F.H. (1994)
    5. Molecular basis of iduronate-2-sulphatase gene mutations in patients with mucopolysaccharidosis type II (Hunter syndrome). (PubMed id 9950361)1, 2, 9 Li P.... Thompson J.N. (1999)
    6. Mutational spectrum of the iduronate-2-sulfatase (IDS) gene in 36 unrelated Russian MPS II patients. (PubMed id 9921913)1, 2, 9 Karsten S.... Bondeson M.-L. (1998)
    7. Molecular diagnosis of mucopolysaccharidosis type II (Hunter syndrome) by automated sequencing and computer-assisted interpretation: toward mutation mapping of the iduronate-2-sulfatase gene. (PubMed id 7887413)1, 2, 9 Jonsson J.J.... Whitley C.B. (1995)
    8. The effect of four mutations on the expression of iduronate-2- sulfatase in mucopolysaccharidosis type II. (PubMed id 11731225)1, 2, 9 Bonuccelli G....Filocamo M. (2001)
    9. Expression of five iduronate-2-sulfatase site-directed mutations. (PubMed id 10838181)1, 2, 9 Villani G.R.D.... Di Natale P. (2000)
    10. Identification of 9 novel gene mutations in 19 unrelated Hunter syndrome (Mucopolysaccharidosis type II) patients. (PubMed id 10671065)1, 2, 9 Karsten S.L.... Bondeson M.-L. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3423 HGNC: 5389 AceView: IDS Ensembl:ENSG00000010404 euGenes: HUgn3423
    ECgene: IDS Kegg: 3423 H-InvDB: IDS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IDS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IDS

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IDS gene:
    Search GeneIP for patents involving IDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IDS (Iduronate 2-Sulfatase/IDS)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IDS (Iduronate 2-Sulfatase/IDS)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IDS   OriGene RNAi products in human, mouse, rat for IDS  
     OriGene qPCR primer pairs and template standards for IDS   OriGene Protein Over-expression Lysate for IDS  
     OriGene MassSpec something-or-other for IDS   OriGene clones in human, mouse for IDS  
     OriGene qSTAR qPCR primer pairs in human, mouse for IDS   OriGene Purified Protein for IDS  
     OriGene ORF clones in mouse, rat for IDS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IDS   OriGene Custom Protein Services for IDS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IDS
     QIAGEN SeqTarget long-range PCR primers for resequencing IDS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDS
     GenScript Custom Purified and Recombinant Proteins Services for IDS GenScript cDNA clones with any tag delivered in your preferred vector for IDS
     GenScript Custom Assay Services for IDS GenScript Superior Antibodies for IDS
     GenScript Custom overexpressing Cell Line Services for IDS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IDS promoter
     Search Chromatin IP Primers for IDS
     RT2 qPCR Primer Assay in human, mouse, rat IDS
     GNC Network for IDS
     SABiosciences Custom PCR Arrays for IDS
     Search Tocris compounds for IDS
     Proteins and Antibodies for IDS
     Cell Lysates for IDS
     cDNA Clones for IDS
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IDS antibodies
     IDS proteins
     IDS lysates
     Antibodies for IDS
     See all of Abcam's Antibodies, Kits and Proteins for IDS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for IDS
     Antibodies for IDS
     ELISAs for IDS
     CLIAs for IDS
     Search LifeMap BioReagents cell lines for IDS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDS
     SwitchGear 3'UTR luciferase reporter plasmids for IDS
     SwitchGear Promoter luciferase reporter plasmids for IDS
     ThermoFisher Antibodies for IDS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IDS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IDS
    Customized:
     lentivirus for stable overexpression of IDS
     lentivirus expression plasmids for stable overexpression of IDS
     adenovirus for overexpression of IDS
     LSBio Antibodies in human, mouse, rat for IDS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IDS gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4