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Aliases for IDS Gene

Aliases for IDS Gene

  • Iduronate 2-Sulfatase 2 3
  • Alpha-L-Iduronate Sulfate Sulfatase 3 4
  • Idursulfase 3 4
  • SIDS 3 4
  • MPS2 3 6
  • Iduronate 2-Sulfatase 14 KDa Chain 3
  • Iduronate 2-Sulfatase 42 KDa Chain 3
  • Hunter Syndrome 2
  • EC 4
  • S 6

External Ids for IDS Gene

Previous HGNC Symbols for IDS Gene

  • SIDS

Previous GeneCards Identifiers for IDS Gene

  • GC0XM143088
  • GC0XM145395
  • GC0XM146459
  • GC0XM147269
  • GC0XM148266
  • GC0XM148369
  • GC0XM148558
  • GC0XM137513

Summaries for IDS Gene

Entrez Gene Summary for IDS Gene

  • The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for IDS Gene

IDS (Iduronate 2-Sulfatase) is a Protein Coding gene. Diseases associated with IDS include mucopolysaccharidosis ii and mucopolysaccharidosis type 2, attenuated form. Among its related pathways are Disease and Lysosome. GO annotations related to this gene include iduronate-2-sulfatase activity. An important paralog of this gene is ARSK.

UniProtKB/Swiss-Prot for IDS Gene

  • Required for the lysosomal degradation of heparan sulfate and dermatan sulfate

Gene Wiki entry for IDS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDS Gene

Genomics for IDS Gene

Regulatory Elements for IDS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IDS Gene

149,476,990 bp from pter
149,521,096 bp from pter
44,107 bases
Minus strand

Genomic View for IDS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDS Gene

Proteins for IDS Gene

  • Protein details for IDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iduronate 2-sulfatase
    Protein Accession:
    Secondary Accessions:
    • D3DWT4
    • Q14604
    • Q9BRM3

    Protein attributes for IDS Gene

    550 amino acids
    Molecular mass:
    61873 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Liver iduronate 2-sulfatase is composed of two major forms (A and B) which contain both a 42 kDa and a 14 kDa polypeptides

    Alternative splice isoforms for IDS Gene


neXtProt entry for IDS Gene

Proteomics data for IDS Gene at MOPED

Post-translational modifications for IDS Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn115, Asn144, Asn246, Asn280, Asn325, Asn513, and Asn537
  • Modification sites at PhosphoSitePlus

Other Protein References for IDS Gene

Antibody Products

  • R&D Systems Antibodies for IDS (Iduronate 2-Sulfatase/IDS)

No data available for DME Specific Peptides for IDS Gene

Domains for IDS Gene

Protein Domains for IDS Gene

Graphical View of Domain Structure for InterPro Entry



  • P22304
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with IDS: view

No data available for Gene Families for IDS Gene

Function for IDS Gene

Molecular function for IDS Gene

GENATLAS Biochemistry:
iduronate 2-sulfatase,lysosomal,acting on dermatan sulfate,heparan sulfate,catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin
UniProtKB/Swiss-Prot Function:
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate

Enzyme Numbers (IUBMB) for IDS Gene

Gene Ontology (GO) - Molecular Function for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004423 iduronate-2-sulfatase activity TAS --
GO:0008484 sulfuric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDS: view
genes like me logo Genes that share phenotypes with IDS: view

Animal Models for IDS Gene

MGI Knock Outs for IDS:

Animal Model Products

No data available for Transcription Factor Targeting and HOMER Transcription for IDS Gene

Localization for IDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDS Gene


Subcellular locations from

Jensen Localization Image for IDS Gene COMPARTMENTS Subcellular localization image for IDS gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with IDS: view

Pathways for IDS Gene

genes like me logo Genes that share pathways with IDS: view

Interacting Proteins for IDS Gene

Selected Interacting proteins: P22304-IDS_HUMAN for IDS Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with IDS: view

Compounds for IDS Gene

(5) HMDB Compounds for IDS Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Chondroitin sulfate B
Heparan sulfate
  • HHS 5
  • Sulfate (ion 2-)
  • Dihydrogen oxide

(11) Novoseek inferred chemical compound relationships for IDS Gene

Compound -log(P) Hits PubMed IDs
iduronate 2-sulfate 81.1 2
dermatan sulfate 75.6 9
dermatan 71.1 2
heparan sulfate 70.6 11
iduronic acid 55.4 2
genes like me logo Genes that share compounds with IDS: view

Transcripts for IDS Gene

Unigene Clusters for IDS Gene

Iduronate 2-sulfatase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IDS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for IDS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IDS Gene

mRNA expression in normal human tissues for IDS Gene

mRNA differential expression in normal tissues according to GTEx for IDS Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.9), Brain - Amygdala (4.6), Brain - Frontal Cortex (BA9) (4.5), and Brain - Hippocampus (4.4).

Protein differential expression in normal tissues for IDS Gene

This gene is overexpressed in NK cells (27.0), Amniocyte (11.2), Vitreous humor (10.6), Cerebrospinal fluid (6.9), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for IDS Gene

SOURCE GeneReport for Unigene cluster for IDS Gene Hs.460960

mRNA Expression by UniProt/SwissProt for IDS Gene

Tissue specificity: Liver, kidney, lung, and placenta
genes like me logo Genes that share expressions with IDS: view

Expression partners for IDS Gene

In Situ Assay Products

Orthologs for IDS Gene

This gene was present in the common ancestor of animals.

Orthologs for IDS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IDS 35
  • 85.5 (n)
  • 86.29 (a)
IDS 36
  • 82 (a)
(Canis familiaris)
Mammalia IDS 35
  • 86.34 (n)
  • 87.87 (a)
IDS 36
  • 86 (a)
(Mus musculus)
Mammalia Ids 35
  • 84.31 (n)
  • 86.13 (a)
Ids 16
Ids 36
  • 85 (a)
(Pan troglodytes)
Mammalia IDS 35
  • 93.84 (n)
  • 91.38 (a)
(Rattus norvegicus)
Mammalia Ids 35
  • 81.92 (n)
  • 82.24 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Gallus gallus)
Aves IDS 35
  • 68.33 (n)
  • 68.15 (a)
IDS 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ids 35
  • 65.16 (n)
  • 68.9 (a)
Str.19540 35
(Danio rerio)
Actinopterygii ids 35
  • 62.62 (n)
  • 63.55 (a)
ids 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4135 35
fruit fly
(Drosophila melanogaster)
Insecta CG12014 37
  • 44 (a)
CG12014 35
  • 51.8 (n)
  • 48.63 (a)
CG12014 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005778 35
  • 53.31 (n)
  • 51.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for IDS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IDS Gene

Gene Tree for IDS (if available)
Gene Tree for IDS (if available)

Paralogs for IDS Gene

Paralogs for IDS Gene Pseudogenes for IDS Gene

genes like me logo Genes that share paralogs with IDS: view

Variants for IDS Gene

Sequence variations from dbSNP and Humsavar for IDS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3832 -- 149,478,884(+) TGATT(A/T)TTTTA utr-variant-3-prime
rs8965 -- 149,479,801(+) AATTT(C/T)GTGGT utr-variant-3-prime
rs11969 -- 149,479,743(+) TATGA(C/T)CAGAA utr-variant-3-prime
rs14950 -- 149,482,666(-) TTTGT(G/T)ATTAC utr-variant-3-prime
rs470715 -- 149,488,441(+) GGCAA(A/C)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDS Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv7147 CNV Insertion 18451855
esv33821 CNV Loss 17666407
nsv518742 CNV Gain 19592680

Relevant External Links for IDS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDS Gene

Disorders for IDS Gene

(1) OMIM Diseases for IDS Gene (300823)


  • Mucopolysaccharidosis 2 (MPS2) [MIM:309900]: An X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation. {ECO:0000269 PubMed:10215411, ECO:0000269 PubMed:10220152, ECO:0000269 PubMed:10447264, ECO:0000269 PubMed:10671065, ECO:0000269 PubMed:11015461, ECO:0000269 PubMed:11683780, ECO:0000269 PubMed:11731225, ECO:0000269 PubMed:12655569, ECO:0000269 PubMed:12794697, ECO:0000269 PubMed:1284597, ECO:0000269 PubMed:1303211, ECO:0000269 PubMed:16699754, ECO:0000269 PubMed:7581397, ECO:0000269 PubMed:7599640, ECO:0000269 PubMed:7728156, ECO:0000269 PubMed:7866405, ECO:0000269 PubMed:7887413, ECO:0000269 PubMed:7981716, ECO:0000269 PubMed:8281149, ECO:0000269 PubMed:8566953, ECO:0000269 PubMed:8664909, ECO:0000269 PubMed:8830188, ECO:0000269 PubMed:8940265, ECO:0000269 PubMed:9222763, ECO:0000269 PubMed:9266380, ECO:0000269 PubMed:9375851, ECO:0000269 PubMed:9452044, ECO:0000269 PubMed:9501270, ECO:0000269 PubMed:9660053, ECO:0000269 PubMed:9762601, ECO:0000269 PubMed:9875019, ECO:0000269 PubMed:9921913, ECO:0000269 PubMed:9950361}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for IDS Gene

(8) Novoseek inferred disease relationships for IDS Gene

Disease -log(P) Hits PubMed IDs
hunters syndrome 98.9 125
mucopolysaccharidosis 82.1 7
sudden infant death syndrome 80.4 18
lysosomal storage diseases 78.3 8
asphyxia 21.9 2

Relevant External Links for IDS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IDS: view

No data available for Genatlas for IDS Gene

Publications for IDS Gene

  1. Mutation analysis of the iduronate-2-sulfatase gene in patients with mucopolysaccharidosis type II (Hunter syndrome). (PMID: 1303211) Bunge S. … Gal A. (Hum. Mol. Genet. 1992) 3 4 23
  2. Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA. (PMID: 2122463) Wilson P.J. … Hopwood J.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  3. Mutations of the iduronate-2-sulfatase (IDS) gene in patients with Hunter syndrome (mucopolysaccharidosis II). (PMID: 7981716) Schroeder W. … Herrmann F.H. (Hum. Mutat. 1994) 3 4 23
  4. Sequence of the human iduronate 2-sulfatase (IDS) gene. (PMID: 8244397) Wilson P.J. … Morris C.P. (Genomics 1993) 3 4 23
  5. Molecular diagnosis of mucopolysaccharidosis type II (Hunter syndrome) by automated sequencing and computer-assisted interpretation: toward mutation mapping of the iduronate-2-sulfatase gene. (PMID: 7887413) Jonsson J.J. … Whitley C.B. (Am. J. Hum. Genet. 1995) 3 4 23

Products for IDS Gene

Sources for IDS Gene

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