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Aliases for IDS Gene

Aliases for IDS Gene

  • Iduronate 2-Sulfatase 2 3 5
  • Alpha-L-Iduronate Sulfate Sulfatase 3 4
  • Idursulfase 3 4
  • SIDS 3 4
  • Iduronate 2-Sulfatase 14 KDa Chain 3
  • Iduronate 2-Sulfatase 42 KDa Chain 3
  • Hunter Syndrome 2
  • EC 3.1.6.13 4
  • MPS2 3

External Ids for IDS Gene

Previous HGNC Symbols for IDS Gene

  • SIDS

Previous GeneCards Identifiers for IDS Gene

  • GC0XM143088
  • GC0XM145395
  • GC0XM146459
  • GC0XM147269
  • GC0XM148266
  • GC0XM148369
  • GC0XM148558
  • GC0XM137513

Summaries for IDS Gene

Entrez Gene Summary for IDS Gene

  • This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for IDS Gene

IDS (Iduronate 2-Sulfatase) is a Protein Coding gene. Diseases associated with IDS include Mucopolysaccharidosis Ii and Mucopolysaccharidosis Type 2, Attenuated Form. Among its related pathways are Defective B4GALT7 causes EDS, progeroid type and Lysosome. GO annotations related to this gene include sulfuric ester hydrolase activity and iduronate-2-sulfatase activity. An important paralog of this gene is ENSG00000241489.

UniProtKB/Swiss-Prot for IDS Gene

  • Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Gene Wiki entry for IDS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDS Gene

Genomics for IDS Gene

Regulatory Elements for IDS Gene

Enhancers for IDS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IDS on UCSC Golden Path with GeneCards custom track

Genomic Location for IDS Gene

Chromosome:
X
Start:
149,476,990 bp from pter
End:
149,521,096 bp from pter
Size:
44,107 bases
Orientation:
Minus strand

Genomic View for IDS Gene

Genes around IDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDS Gene

Proteins for IDS Gene

  • Protein details for IDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22304-IDS_HUMAN
    Recommended name:
    Iduronate 2-sulfatase
    Protein Accession:
    P22304
    Secondary Accessions:
    • D3DWT4
    • Q14604
    • Q9BRM3

    Protein attributes for IDS Gene

    Size:
    550 amino acids
    Molecular mass:
    61873 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Liver iduronate 2-sulfatase is composed of two major forms (A and B) which contain both a 42 kDa and a 14 kDa polypeptides.

    Alternative splice isoforms for IDS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDS Gene

Post-translational modifications for IDS Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 115, Asn 144, Asn 246, Asn 280, Asn 325, Asn 513, and Asn 537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IDS Gene

Domains & Families for IDS Gene

Gene Families for IDS Gene

Protein Domains for IDS Gene

Graphical View of Domain Structure for InterPro Entry

P22304

UniProtKB/Swiss-Prot:

IDS_HUMAN :
  • Belongs to the sulfatase family.
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with IDS: view

Function for IDS Gene

Molecular function for IDS Gene

GENATLAS Biochemistry:
iduronate 2-sulfatase,lysosomal,acting on dermatan sulfate,heparan sulfate,catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
UniProtKB/Swiss-Prot Function:
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Enzyme Numbers (IUBMB) for IDS Gene

Gene Ontology (GO) - Molecular Function for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004423 iduronate-2-sulfatase activity TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDS: view
genes like me logo Genes that share phenotypes with IDS: view

Human Phenotype Ontology for IDS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IDS Gene

MGI Knock Outs for IDS:

Animal Model Products

  • Taconic Biosciences Mouse Models for IDS

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for IDS Gene

Localization for IDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDS Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDS Gene COMPARTMENTS Subcellular localization image for IDS gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with IDS: view

Pathways & Interactions for IDS Gene

genes like me logo Genes that share pathways with IDS: view

Interacting Proteins for IDS Gene

Gene Ontology (GO) - Biological Process for IDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0030207 chondroitin sulfate catabolic process TAS --
genes like me logo Genes that share ontologies with IDS: view

No data available for SIGNOR curated interactions for IDS Gene

Drugs & Compounds for IDS Gene

(6) Drugs for IDS Gene - From: ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Kava Nutra 137
IDURONATE-2 SULFATASE Pharma 0
calcium Nutra 0

(9) Additional Compounds for IDS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
9050-30-0
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
genes like me logo Genes that share compounds with IDS: view

Transcripts for IDS Gene

Unigene Clusters for IDS Gene

Iduronate 2-sulfatase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for IDS Gene

GeneLoc Exon Structure for
IDS
ECgene alternative splicing isoforms for
IDS

Expression for IDS Gene

mRNA expression in normal human tissues for IDS Gene

mRNA differential expression in normal tissues according to GTEx for IDS Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.9), Brain - Amygdala (x4.6), Brain - Frontal Cortex (BA9) (x4.5), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for IDS Gene

This gene is overexpressed in NK cells (27.0), Amniocyte (11.2), Vitreous humor (10.6), Cerebrospinal fluid (6.9), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDS Gene



Protein tissue co-expression partners for IDS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IDS Gene:

IDS

SOURCE GeneReport for Unigene cluster for IDS Gene:

Hs.460960

mRNA Expression by UniProt/SwissProt for IDS Gene:

P22304-IDS_HUMAN
Tissue specificity: Liver, kidney, lung, and placenta.
genes like me logo Genes that share expression patterns with IDS: view

Primer Products

Orthologs for IDS Gene

This gene was present in the common ancestor of animals.

Orthologs for IDS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IDS 34
  • 85.5 (n)
  • 86.29 (a)
IDS 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IDS 34
  • 86.34 (n)
  • 87.87 (a)
IDS 35
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ids 34
  • 84.31 (n)
  • 86.13 (a)
Ids 16
Ids 35
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia IDS 34
  • 93.84 (n)
  • 91.38 (a)
rat
(Rattus norvegicus)
Mammalia Ids 34
  • 81.92 (n)
  • 82.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves IDS 34
  • 68.33 (n)
  • 68.15 (a)
IDS 35
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ids 34
  • 65.16 (n)
  • 68.9 (a)
Str.19540 34
zebrafish
(Danio rerio)
Actinopterygii ids 34
  • 62.62 (n)
  • 63.55 (a)
ids 35
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4135 34
fruit fly
(Drosophila melanogaster)
Insecta CG12014 36
  • 44 (a)
CG12014 34
  • 51.8 (n)
  • 48.63 (a)
CG12014 35
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005778 34
  • 53.31 (n)
  • 51.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for IDS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IDS Gene

ENSEMBL:
Gene Tree for IDS (if available)
TreeFam:
Gene Tree for IDS (if available)

Paralogs for IDS Gene

Paralogs for IDS Gene

Pseudogenes.org Pseudogenes for IDS Gene

genes like me logo Genes that share paralogs with IDS: view

Variants for IDS Gene

Sequence variations from dbSNP and Humsavar for IDS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_007313 Mucopolysaccharidosis 2 (MPS2)
VAR_007314 Mucopolysaccharidosis 2 (MPS2)
VAR_007315 Mucopolysaccharidosis 2 (MPS2)
VAR_007316 Mucopolysaccharidosis 2 (MPS2)
VAR_007317 Mucopolysaccharidosis 2 (MPS2)

Structural Variations from Database of Genomic Variants (DGV) for IDS Gene

Variant ID Type Subtype PubMed ID
esv33821 CNV loss 17666407
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680
nsv7147 CNV insertion 18451855

Variation tolerance for IDS Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDS Gene

Human Gene Mutation Database (HGMD)
IDS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDS Gene

Disorders for IDS Gene

MalaCards: The human disease database

(10) MalaCards diseases for IDS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucopolysaccharidosis ii
  • mucopolysaccharidosis, type ii
mucopolysaccharidosis type 2, attenuated form
  • hunter syndrome type b
mucopolysaccharidosis type 2, severe form
  • hunter syndrome type a
mucopolysaccharidosis
  • mps
lysosomal storage disease
  • disorder of lysosomal enzyme
- elite association - COSMIC cancer census association via MalaCards
Search IDS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IDS_HUMAN
  • Mucopolysaccharidosis 2 (MPS2) [MIM:309900]: An X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation. {ECO:0000269 PubMed:10215411, ECO:0000269 PubMed:10220152, ECO:0000269 PubMed:10447264, ECO:0000269 PubMed:10671065, ECO:0000269 PubMed:11015461, ECO:0000269 PubMed:11683780, ECO:0000269 PubMed:11731225, ECO:0000269 PubMed:12655569, ECO:0000269 PubMed:12794697, ECO:0000269 PubMed:1284597, ECO:0000269 PubMed:1303211, ECO:0000269 PubMed:16699754, ECO:0000269 PubMed:7581397, ECO:0000269 PubMed:7599640, ECO:0000269 PubMed:7728156, ECO:0000269 PubMed:7866405, ECO:0000269 PubMed:7887413, ECO:0000269 PubMed:7981716, ECO:0000269 PubMed:8281149, ECO:0000269 PubMed:8566953, ECO:0000269 PubMed:8664909, ECO:0000269 PubMed:8830188, ECO:0000269 PubMed:8940265, ECO:0000269 PubMed:9222763, ECO:0000269 PubMed:9266380, ECO:0000269 PubMed:9375851, ECO:0000269 PubMed:9452044, ECO:0000269 PubMed:9501270, ECO:0000269 PubMed:9660053, ECO:0000269 PubMed:9762601, ECO:0000269 PubMed:9875019, ECO:0000269 PubMed:9921913, ECO:0000269 PubMed:9950361}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IDS

Genetic Association Database (GAD)
IDS
Human Genome Epidemiology (HuGE) Navigator
IDS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDS
genes like me logo Genes that share disorders with IDS: view

No data available for Genatlas for IDS Gene

Publications for IDS Gene

  1. Multiple cryptic splice sites can be activated by IDS point mutations generating misspliced transcripts. (PMID: 16699754) Lualdi S. … Filocamo M. (J. Mol. Med. 2006) 3 4 22 65
  2. Mutational spectrum of the iduronate 2 sulfatase gene in 25 unrelated Korean Hunter syndrome patients: identification of 13 novel mutations. (PMID: 12655569) Kim C.H. … Jin D.-K. (Hum. Mutat. 2003) 3 4 22 65
  3. The effect of four mutations on the expression of iduronate-2- sulfatase in mucopolysaccharidosis type II. (PMID: 11731225) Bonuccelli G. … Filocamo M. (Biochim. Biophys. Acta 2001) 3 4 22 65
  4. Expression of five iduronate-2-sulfatase site-directed mutations. (PMID: 10838181) Villani G.R.D. … Di Natale P. (Biochim. Biophys. Acta 2000) 3 4 22 65
  5. Molecular basis of iduronate-2-sulphatase gene mutations in patients with mucopolysaccharidosis type II (Hunter syndrome). (PMID: 9950361) Li P. … Thompson J.N. (J. Med. Genet. 1999) 3 4 22 65

Products for IDS Gene

Sources for IDS Gene

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