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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IDO2 Gene

protein-coding GIFtS: 52
GCID: GC08P039792

indoleamine 2,3-dioxygenase 2

(Previous name: indoleamine-pyrrole 2,3 dioxygenase-like 1 )
(Previous symbol: INDOL1)

Explore 4 diseases affiliated with
IDO2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Indoleamine 2,3-Dioxygenase 2¹ ²		Indoleamine-Pyrrole 2,3-Dioxygenase-Like Protein 1² ³
INDOL1¹ ² ³ ⁵		IDO-2² ³
Indoleamine-Pyrrole 2,3 Dioxygenase-Like 1¹ ²		Indoleamine 2,3-Dioxygenase-Like 1 Protein²
Indoleamine 2,3-Dioxygenase-Like Protein 1² ³		EC 1.13.11.-³

External Ids:	HGNC: 27269¹	Entrez Gene: 169355²	Ensembl: ENSG00000188676⁷	OMIM: 612129⁵	UniProtKB: Q6ZQW0³

Export aliases for IDO2 gene to outside databases

Previous GC identifers: GC08P039913 GC08P038325

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDO2:

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1

gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 (PubMed 17499941)).(supplied by OMIM, Feb

2011)

UniProtKB/Swiss-Prot: I23O2_HUMAN, Q6ZQW0

Function: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IDO2 gene promoter:
GR GR-beta LUN-1 POU3F2 C/EBPalpha CHOP-10 FOXO1a GR-alpha NF-kappaB1 FOXO1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for IDO2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDO2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.21

IDO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDO2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039792: view genomic region (about GC identifiers)

Start:	39,792,133 bp from pter	End:	39,873,910 bp from pter
Size:	81,778 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I23O2_HUMAN, Q6ZQW0 (See protein sequence)

Recommended Name: Indoleamine 2,3-dioxygenase 2

Size: 407 amino acids; 45424 Da

Cofactor: Binds 1 heme group per subunit (By similarity)

Secondary accessions: A4UD41

Alternative splicing: 2 isoforms: Q6ZQW0-1 Q6ZQW0-2

Explore the universe of human proteins at neXtProt for IDO2: NX_Q6ZQW0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZQW0

IDO2 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_919270.2

ENSEMBL proteins:

ENSP00000426447 ENSP00000443432

Reactome Protein details: Q6ZQW0
Human Recombinant Protein Products for IDO2:

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	Uscn Proteins for IDO2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	17499941
GO:0005829	cytosol	TAS	--

IDO2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for IDO2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IDO2 for domains About GeneDecksing

1 InterPro domain/family:

IPR000898 Indolamine_dOase

Graphical View of Domain Structure for InterPro Entry Q6ZQW0

ProtoNet protein and cluster: Q6ZQW0

UniProtKB/Swiss-Prot: I23O2_HUMAN, Q6ZQW0

Similarity: Belongs to the indoleamine 2,3-dioxygenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: I23O2_HUMAN, Q6ZQW0

Function: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism

Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

Enzyme regulation: Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp

(methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan)

Enzyme Number (IUBMB): EC 1.13.11.-¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004833	tryptophan 2,3-dioxygenase activity	EXP	--
GO:0020037	heme binding	IEA	--
GO:0033754	indoleamine 2,3-dioxygenase activity	ISS	17499941
GO:0046872	metal ion binding	IEA	--

IDO2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IDO2

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		hsa-miR-617 hsa-miR-590-3p hsa-miR-548c-3p hsa-miR-1976
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

African trypanosomiasis

African trypanosomiasis

1.00

Tryptophan metabolism

Tryptophan metabolism

0.47

tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

Tryptophan catabolism

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for IDO2

	Tryptophan catabolism
	Metabolism
	Metabolism of amino acids and derivatives

3 Kegg Pathways (Kegg details for IDO2):

	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis

UniProtKB/Swiss-Prot: I23O2_HUMAN, Q6ZQW0

Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step

1/2

IDO2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IDO2

5/11 Interacting proteins for IDO2 (Q6ZQW0³) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AMT	P48728³	I2D: score=1
DLAT	P10515³	I2D: score=1
DNAJA1	P31689³	I2D: score=1
GGPS1	O95749³	I2D: score=1
GPT2	Q8TD30³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006569	tryptophan catabolic process	TAS	--
GO:0019441	tryptophan catabolic process to kynurenine	ISS	17499941
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

IDO2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IDO2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IDO2

Browse Tocris compounds for IDO2

8 HMDB Compounds for IDO2 About this table

Compound	Synonyms	CAS #	PubMed Ids
5-Hydroxy-L-tryptophan	(+-)-5-Hydroxytryptophan (see all 21)	4350-09-8	--
5-Hydroxy-N-formylkynurenine		--	--
Acetyl-N-formyl-5-methoxykynurenamine	N-Acetyl-N-formyl-5-methoxykynurenamine (see all 4)	52450-38-1	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
L-Tryptophan	(-)-tryptophan (see all 53)	73-22-3	--
N'-Formylkynurenine	3-(N-formylanthraniloyl)-Alanine (see all 9)	1022-31-7	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--

Search CenterWatch for drugs/clinical trials and news about IDO2 / I23O2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IDO2 gene:

NM_194294.2

Unigene Cluster for IDO2:

Indoleamine 2,3-dioxygenase 2

Hs.676257 [show with all ESTs]

Unigene Representative Sequence: NM_194294

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000343295(uc003xno.1) ENST00000389060 ENST00000421393(uc010lwz.1)

ENST00000418094(uc003xnp.1) ENST00000502986(uc010lwy.1)

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		4 QIAGEN miScript miRNA Assays for microRNAs that regulate IDO2:
		hsa-miR-617 hsa-miR-590-3p hsa-miR-548c-3p hsa-miR-1976
		SwitchGear 3'UTR luciferase reporter plasmid: IDO2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK092502.1 BC031685.1 BC113496.1 BC113498.1 EF052681.1

3 DOTS entries:

DT.101976508 DT.91754675 DT.95315279

9 AceView cDNA sequences:

BQ022530 NM_194294 BC031685 AK092502 BQ024836 AK128691 BI828101 BQ023022

BF439877

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IDO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAACCCCC

About this image

IDO2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for IDO2

SOURCE GeneReport for Unigene cluster: Hs.676257

UniProtKB/Swiss-Prot: I23O2_HUMAN, Q6ZQW0

Tissue specificity: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ido2^{1 , 5}	indoleamine 2,3-dioxygenase 2^{1, 5}	76.78(n)¹ 73.38(a)¹		8 (12.58 cM)⁵ 209176¹ NM_145949.2¹ NP_666061.3¹ 24531894⁵
chicken (Gallus gallus)	Aves	INDOL1¹	indoleamine-pyrrole 2,3 dioxygenase-like 1	64.43(n) 60.05(a)		426785 XM_424397.3 XP_424397.3
lizard (Anolis carolinensis)	Reptilia	IDO2⁶	--	54(a)	1 ↔ 1	GL343418.1(676211-709277)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1465²	Xenopus laevis, Similar to hypothetical protein MGC31194, more	72(n)		BC046253.1
zebrafish (Danio rerio)	Actinopterygii	ido1¹	indoleamine 2,3-dioxygenase 1	59.01(n) 51.28(a)		571967 NM_001083854.1 NP_001077323.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	BNA2¹	Bna2p	44.85(n) 36.41(a)		853541 NP_012612.3

ENSEMBL Gene Tree for IDO2 (if available)
TreeFam Gene Tree for IDO2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IDO2 gene

IDO1²

1 SIMAP similar gene for IDO2 using alignment to 3 protein entries: I23O2_HUMAN (see all proteins):

IDO1

IDO2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6991530^1,2	C,F,A,H	--	39790600(+)	`ATTCTT/GTAGCT`	1	--	us2k¹		15		NS EA NA WA CSA	791
rs115935815^1,2		--	39790613(+)	`TGCCTC/TATATA`	1	--	us2k¹		1		WA	118
rs114425474^1,2		--	39790689(+)	`CTATAT/CTAAAT`	1	--	us2k¹		1		WA	118
rs190993982^1,2		--	39790860(+)	`AATTGA/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs183307810^1,2		--	39790950(+)	`AAATGG/TCCCAC`	1	--	us2k¹		0	--	--	--	--
rs144048249^1,2		--	39791033(+)	`CTGCTC/TCTAAT`	1	--	us2k¹		0	--	--	--	--
rs188352474^1,2		--	39791087(+)	`TTATTA/GCTCTC`	1	--	us2k¹		0	--	--	--	--
rs76426750^1,2	F	--	39791096(+)	`TCCTCA/GTTTTA`	1	--	us2k¹		1		WA	118
rs138660466^1,2		--	39791206(+)	`TTACTA/GTAATA`	1	--	us2k¹		0	--	--	--	--
rs10504013^1,2	C,F,H	--	39791316(+)	`TCTTTT/CAGTTG`	1	--	us2k¹		97		NS EA NA PA EU CA WA CSA	5164

HapMap Linkage Disequilibrium report for IDO2 (39792133 - 39873910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IDO2: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDO2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IDO2 for disorders           About GeneDecksing

OMIM gene information: 612129    OMIM disorders: --

4 diseases for IDO2:    About MalaCards

trypanosomiasis hepatitis b hepatitis melanoma

Human Genome Epidemiology (HuGE) Navigator: IDO2 (1 document)

Export disorders for IDO2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IDO2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with IDO2)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. (PubMed id 17499941)^{1, 2} Ball H.J.... Hunt N.H. (2007)
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. (PubMed id 17671174)^{1, 2} Metz R....Prendergast G.C. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The human indoleamine 2,3-dioxygenase gene and related human genes. (PubMed id 17430106)^{1, 9} Murray M.F. (2007)
Purification and kinetic characterization of human ind oleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO 1 inhibitors. (PubMed id 21835273)¹ Meininger D....Sutherland C.L. (2011)
Indoleamine 2,3-dioxygenase mediates the antiviral ef fect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells. (PubMed id 21084489)¹ Mao R....Guo H. (2011)
Spontaneous cytotoxic T-Cell reactivity against indol eamine 2,3-dioxygenase-2. (PubMed id 21406395)¹ SA...Andersen M.H. (2011)
Induction of indoleamine 2, 3-dioxygenase by death re ceptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. (PubMed id 19799997)¹ Cetindere T....Hassan M. (2010)
High activity of indoleamine 2,3 dioxygenase enzyme p redicts disease severity and case fatality in bacteremic patients. (PubMed id 19487973)¹ Huttunen R....Hurme M. (2010)
Genotyping and expression analysis of IDO2 in human p ancreatic cancer: a novel, active target. (PubMed id 19476837)¹ Witkiewicz A.K....Brody J.R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 169355	HGNC: 27269	AceView: LOC169355	Ensembl:ENSG00000188676	euGenes: HUgn169355
ECgene: IDO2	Kegg: 169355	H-InvDB: IDO2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IDO2	Pharmacogenomics, SNPs, Pathways

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