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Aliases for IDO2 Gene

Aliases for IDO2 Gene

  • Indoleamine 2,3-Dioxygenase 2 2 3
  • INDOL1 3 4 6
  • Indoleamine-Pyrrole 2,3-Dioxygenase-Like Protein 1 3 4
  • Indoleamine-Pyrrole 2,3 Dioxygenase-Like 1 2 3
  • Indoleamine 2,3-Dioxygenase-Like Protein 1 3 4
  • IDO-2 3 4
  • Indoleamine 2,3-Dioxygenase-Like 1 Protein 3
  • EC 1.13.11.- 4

External Ids for IDO2 Gene

Previous Symbols for IDO2 Gene

  • INDOL1

Summaries for IDO2 Gene

Entrez Gene Summary for IDO2 Gene

  • Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

GeneCards Summary for IDO2 Gene

IDO2 (Indoleamine 2,3-Dioxygenase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include heme binding and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO1.

UniProtKB/Swiss-Prot for IDO2 Gene

  • Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDO2 Gene

Genomics for IDO2 Gene

Genomic Location for IDO2 Gene

Start:
39,934,614 bp from pter
End:
40,016,391 bp from pter
Size:
81,778 bases
Orientation:
Plus strand

Genomic View for IDO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDO2 Gene

Regulatory Elements for IDO2 Gene

Proteins for IDO2 Gene

  • Protein details for IDO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQW0-I23O2_HUMAN
    Recommended name:
    Indoleamine 2,3-dioxygenase 2
    Protein Accession:
    Q6ZQW0
    Secondary Accessions:
    • A4UD41

    Protein attributes for IDO2 Gene

    Size:
    407 amino acids
    Molecular mass:
    45424 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IDO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDO2 Gene

Proteomics data for IDO2 Gene at MOPED

Post-translational modifications for IDO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IDO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IDO2 Gene

Domains for IDO2 Gene

Protein Domains for IDO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IDO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZQW0

UniProtKB/Swiss-Prot:

I23O2_HUMAN
Family:
  • Belongs to the indoleamine 2,3-dioxygenase family.:
    • Q6ZQW0
genes like me logo Genes that share domains with IDO2: view

No data available for Gene Families for IDO2 Gene

Function for IDO2 Gene

Molecular function for IDO2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-tryptophan + O(2) = N-formyl-L-kynurenine.
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan).
UniProtKB/Swiss-Prot Function: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

Enzyme Numbers (IUBMB) for IDO2 Gene

Gene Ontology (GO) - Molecular Function for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004833 tryptophan 2,3-dioxygenase activity EXP --
GO:0020037 heme binding IEA --
GO:0033754 indoleamine 2,3-dioxygenase activity ISS 17499941
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDO2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IDO2 Gene

Localization for IDO2 Gene

Gene Ontology (GO) - Cellular Components for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 17499941
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IDO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IDO2 Gene

Pathways for IDO2 Gene

genes like me logo Genes that share pathways with IDO2: view

Pathways by source for IDO2 Gene

UniProtKB/Swiss-Prot Q6ZQW0-I23O2_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2

Interacting Proteins for IDO2 Gene

Gene Ontology (GO) - Biological Process for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006569 tryptophan catabolic process TAS --
GO:0019441 tryptophan catabolic process to kynurenine ISS 17499941
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDO2: view

Compounds for IDO2 Gene

(8) HMDB Compounds for IDO2 Gene

Compound Synonyms Cas Number PubMed IDs
5-Hydroxy-L-tryptophan
  • (+-)-5-Hydroxytryptophan
4350-09-8
5-Hydroxy-N-formylkynurenine
Not Available
Acetyl-N-formyl-5-methoxykynurenamine
  • N-Acetyl-N-formyl-5-methoxykynurenamine
52450-38-1
Heme
  • (protoporphyrinato)iron
14875-96-8
L-Tryptophan
  • (-)-tryptophan
73-22-3
genes like me logo Genes that share compounds with IDO2: view

Transcripts for IDO2 Gene

mRNA/cDNA for IDO2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IDO2 Gene

Indoleamine 2,3-dioxygenase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IDO2 Gene

No ASD Table

Relevant External Links for IDO2 Gene

GeneLoc Exon Structure for
IDO2
ECgene alternative splicing isoforms for
IDO2

Expression for IDO2 Gene

mRNA expression in normal human tissues for IDO2 Gene

mRNA differential expression in normal tissues according to GTEx for IDO2 Gene

This gene is overexpressed in Liver (28.7), Thyroid (7.7), and Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IDO2 Gene

SOURCE GeneReport for Unigene cluster for IDO2 Gene Hs.676257

mRNA Expression by UniProt/SwissProt for IDO2 Gene

Q6ZQW0-I23O2_HUMAN
Tissue specificity: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon.
genes like me logo Genes that share expressions with IDO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IDO2 Gene

Orthologs for IDO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDO2 35
  • 99.01 (n)
  • 98.64 (a)
IDO2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IDO2 35
  • 79.85 (n)
  • 75.68 (a)
IDO2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDO2 35
  • 83.91 (n)
  • 79.46 (a)
IDO2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ido2 35
  • 76.78 (n)
  • 73.38 (a)
Ido2 16
Ido2 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IDO2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDO2 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ido2 35
  • 78.45 (n)
  • 76.18 (a)
chicken
(Gallus gallus)
Aves IDO2 36
  • 60 (a)
OneToOne
INDOL1 35
  • 64.43 (n)
  • 60.05 (a)
lizard
(Anolis carolinensis)
Reptilia IDO2 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1465 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ido1 35
  • 57.88 (n)
  • 53.52 (a)
zebrafish
(Danio rerio)
Actinopterygii ido1 35
  • 59.01 (n)
  • 51.28 (a)
ido1 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA2 36
  • 29 (a)
OneToMany
Species with no ortholog for IDO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IDO2 Gene

ENSEMBL:
Gene Tree for IDO2 (if available)
TreeFam:
Gene Tree for IDO2 (if available)

Paralogs for IDO2 Gene

Paralogs for IDO2 Gene

Selected SIMAP similar genes for IDO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IDO2: view

Variants for IDO2 Gene

Sequence variations from dbSNP and Humsavar for IDO2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs877290 -- 39,998,204(-) TGTTC(A/G)TCAGC intron-variant
rs877291 -- 39,998,141(-) CAGTG(C/G)AGAGG intron-variant
rs888443 -- 39,997,664(+) AATAA(A/G)TAAAT intron-variant
rs888444 -- 39,998,435(+) TCCAG(G/T)GCAGT intron-variant
rs950911 -- 39,934,073(-) GCTGG(A/G)CATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IDO2 Gene

Variant ID Type Subtype PubMed ID
esv2736908 CNV Deletion 23290073
esv2663657 CNV Deletion 23128226
esv1987205 CNV Deletion 18987734
esv2677111 CNV Deletion 23128226

Relevant External Links for IDO2 Gene

HapMap Linkage Disequilibrium report
IDO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDO2 Gene

Disorders for IDO2 Gene

Relevant External Links for IDO2

Genetic Association Database (GAD)
IDO2
Human Genome Epidemiology (HuGE) Navigator
IDO2
genes like me logo Genes that share disorders with IDO2: view

No data available for UniProtKB/Swiss-Prot for IDO2 Gene

Publications for IDO2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. (PMID: 17499941) Ball H.J. … Hunt N.H. (Gene 2007) 3 4
  3. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. (PMID: 17671174) Metz R. … Prendergast G.C. (Cancer Res. 2007) 3 4
  4. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. (PMID: 19476837) Witkiewicz A.K. … Brody J.R. (J. Am. Coll. Surg. 2009) 3 48
  5. The human indoleamine 2,3-dioxygenase gene and related human genes. (PMID: 17430106) Murray M.F. (Curr. Drug Metab. 2007) 3 23

Products for IDO2 Gene

Sources for IDO2 Gene

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