Aliases for IDO2 Gene
External Ids for IDO2 Gene
Previous HGNC Symbols for IDO2 Gene
Previous GeneCards Identifiers for IDO2 Gene
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
GeneCards Summary for IDO2 Gene
IDO2 (Indoleamine 2,3-Dioxygenase 2) is a Protein Coding gene. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Tryptophan metabolism. GO annotations related to this gene include heme binding and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO1.
UniProtKB/Swiss-Prot for IDO2 Gene
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).