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Aliases for IDO1 Gene

Aliases for IDO1 Gene

  • Indoleamine 2,3-Dioxygenase 1 2 3
  • INDO 3 4 6
  • IDO 3 4 6
  • Indoleamine-Pyrrole 2,3-Dioxygenase 3 4
  • IDO-1 3 4
  • Indoleamine-Pyrrole 2,3 Dioxygenase 2
  • Indolamine 2,3 Dioxygenase 3
  • Indole 2,3-Dioxygenase 3
  • EC 1.13.11.52 4

External Ids for IDO1 Gene

Previous HGNC Symbols for IDO1 Gene

  • IDO
  • INDO

Previous GeneCards Identifiers for IDO1 Gene

  • GC08P039771
  • GC08P038304

Summaries for IDO1 Gene

Entrez Gene Summary for IDO1 Gene

  • This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

GeneCards Summary for IDO1 Gene

IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include toxic oil syndrome and listeriosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO2.

UniProtKB/Swiss-Prot for IDO1 Gene

  • Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.

Gene Wiki entry for IDO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDO1 Gene

Genomics for IDO1 Gene

Regulatory Elements for IDO1 Gene

Genomic Location for IDO1 Gene

Start:
39,902,275 bp from pter
End:
39,928,790 bp from pter
Size:
26,516 bases
Orientation:
Plus strand

Genomic View for IDO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDO1 Gene

Proteins for IDO1 Gene

  • Protein details for IDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14902-I23O1_HUMAN
    Recommended name:
    Indoleamine 2,3-dioxygenase 1
    Protein Accession:
    P14902
    Secondary Accessions:
    • Q540B4

    Protein attributes for IDO1 Gene

    Size:
    403 amino acids
    Molecular mass:
    45326 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IDO1 Gene

neXtProt entry for IDO1 Gene

Proteomics data for IDO1 Gene at MOPED

Post-translational modifications for IDO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IDO1 Gene

Antibody Products

  • R&D Systems Antibodies for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
  • Cell Signaling Technology (CST) Antibodies for IDO1 (INDO)

No data available for DME Specific Peptides for IDO1 Gene

Domains for IDO1 Gene

Protein Domains for IDO1 Gene

Suggested Antigen Peptide Sequences for IDO1 Gene

Graphical View of Domain Structure for InterPro Entry

P14902

UniProtKB/Swiss-Prot:

I23O1_HUMAN :
  • P14902
Family:
  • Belongs to the indoleamine 2,3-dioxygenase family.
genes like me logo Genes that share domains with IDO1: view

No data available for Gene Families for IDO1 Gene

Function for IDO1 Gene

Molecular function for IDO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21.23 uM for L-tryptophan {ECO:0000269 PubMed:18026683}; KM=4.6 mM for D-tryptophan {ECO:0000269 PubMed:18026683}; Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan.;
UniProtKB/Swiss-Prot CatalyticActivity:
D-tryptophan + O(2) = N-formyl-D-kynurenine.
UniProtKB/Swiss-Prot CatalyticActivity:
L-tryptophan + O(2) = N-formyl-L-kynurenine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan).
UniProtKB/Swiss-Prot Function:
Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for IDO1 Gene

Gene Ontology (GO) - Molecular Function for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004833 tryptophan 2,3-dioxygenase activity EXP --
GO:0005515 protein binding --
GO:0009055 electron carrier activity TAS 2109605
GO:0020037 heme binding IEA --
GO:0033754 indoleamine 2,3-dioxygenase activity IMP 25310899
genes like me logo Genes that share ontologies with IDO1: view
genes like me logo Genes that share phenotypes with IDO1: view

Animal Models for IDO1 Gene

MGI Knock Outs for IDO1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IDO1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for IDO1 Gene

Localization for IDO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDO1 Gene COMPARTMENTS Subcellular localization image for IDO1 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0030485 smooth muscle contractile fiber IEA --
GO:0032421 stereocilium bundle IEA --
genes like me logo Genes that share ontologies with IDO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IDO1 Gene

Pathways for IDO1 Gene

genes like me logo Genes that share pathways with IDO1: view

Pathways by source for IDO1 Gene

1 Cell Signaling Technology pathway for IDO1 Gene
2 BioSystems pathways for IDO1 Gene
1 GeneGo (Thomson Reuters) pathway for IDO1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Amino Acid Metabolism I in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat

UniProtKB/Swiss-Prot P14902-I23O1_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2

Interacting Proteins for IDO1 Gene

Gene Ontology (GO) - Biological Process for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002534 cytokine production involved in inflammatory response IEA --
GO:0002666 positive regulation of T cell tolerance induction IEA --
GO:0002678 positive regulation of chronic inflammatory response IEA --
GO:0002830 positive regulation of type 2 immune response IEA --
GO:0006569 tryptophan catabolic process TAS --
genes like me logo Genes that share ontologies with IDO1: view

Compounds for IDO1 Gene

Compound Products

(4) ApexBio Compounds for IDO1 Gene

Compound Action Cas Number
IDO inhibitor 1 "Indoleamine-2,3-dioxygenase inhibitor" [1204669-37-3]
INCB024360 Potent IDO1 inhibitor [914471-09-3]
Indoximod (NLG-8189) "Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor Potent and selective HDAC6 inhibitor" [110117-83-4]
NLG919 Potent IDO pathway inhibitor [1402836-58-1]

(9) HMDB Compounds for IDO1 Gene

Compound Synonyms Cas Number PubMed IDs
5-Hydroxy-L-tryptophan
  • (+-)-5-Hydroxytryptophan
4350-09-8
5-Hydroxy-N-formylkynurenine
Not Available
D-Tryptophan
  • (+)-tryptophan
153-94-6
Formyl-5-hydroxykynurenamine
  • 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole
2208-41-5
Heme
  • (protoporphyrinato)iron
14875-96-8

(2) Drugbank Compounds for IDO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Tryptophan
  • (-)-Tryptophan
73-22-3 enzyme substrate
Melatonin
  • MEL
73-31-4 enzyme substrate

(57) Novoseek inferred chemical compound relationships for IDO1 Gene

Compound -log(P) Hits PubMed IDs
indoleamine 99.1 119
kynurenine 97.2 160
1-methyltryptophan 95.2 38
1-methyl-d-tryptophan 90.2 8
n-formylkynurenine 88.7 14

(2) PharmGKB related drug/compound annotations for IDO1 Gene

genes like me logo Genes that share compounds with IDO1: view

Transcripts for IDO1 Gene

Unigene Clusters for IDO1 Gene

Indoleamine 2,3-dioxygenase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IDO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDO1 Gene

No ASD Table

Relevant External Links for IDO1 Gene

GeneLoc Exon Structure for
IDO1
ECgene alternative splicing isoforms for
IDO1

Expression for IDO1 Gene

mRNA expression in normal human tissues for IDO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDO1 Gene

This gene is overexpressed in Lung (10.6), Brain - Substantia nigra (5.8), Adipose - Visceral (Omentum) (5.2), Cervix - Endocervix (4.3), and Small Intestine - Terminal Ileum (4.2).

Protein differential expression in normal tissues for IDO1 Gene

This gene is overexpressed in Nasopharynx (50.5) and Ovary (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IDO1 Gene

SOURCE GeneReport for Unigene cluster for IDO1 Gene Hs.840

genes like me logo Genes that share expressions with IDO1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for IDO1 Gene

Orthologs for IDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IDO1 35
  • 78.89 (n)
  • 70.1 (a)
IDO1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDO1 35
  • 78.62 (n)
  • 68.18 (a)
IDO1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ido1 35
  • 72.24 (n)
  • 62.53 (a)
Ido1 16
Ido1 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IDO1 35
  • 99.26 (n)
  • 99.01 (a)
IDO1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ido1 35
  • 72.41 (n)
  • 63.8 (a)
oppossum
(Monodelphis domestica)
Mammalia IDO1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDO1 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR188C 35
  • 44.79 (n)
  • 34.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA2 35
  • 45 (n)
  • 35.29 (a)
BNA2 36
  • 27 (a)
OneToMany
BNA2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU05752 35
  • 45.38 (n)
  • 37.47 (a)
Species with no ortholog for IDO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IDO1 Gene

ENSEMBL:
Gene Tree for IDO1 (if available)
TreeFam:
Gene Tree for IDO1 (if available)

Paralogs for IDO1 Gene

Paralogs for IDO1 Gene

Selected SIMAP similar genes for IDO1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IDO1: view

Variants for IDO1 Gene

Sequence variations from dbSNP and Humsavar for IDO1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1811283 -- 39,926,138(+) ACCGA(G/T)ATGGC intron-variant
rs1981789 -- 39,925,906(+) taaaa(A/G)gCCAG intron-variant
rs2302843 -- 39,925,135(+) CTTCT(A/G)TTCAG intron-variant
rs3739319 -- 39,927,802(+) CCTCC(A/G)TATTT intron-variant
rs3808606 -- 39,911,856(-) CAGGT(C/T)GTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IDO1 Gene

Variant ID Type Subtype PubMed ID
nsv508505 CNV Loss 20534489
esv2658388 CNV Deletion 23128226

Relevant External Links for IDO1 Gene

HapMap Linkage Disequilibrium report
IDO1
Human Gene Mutation Database (HGMD)
IDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDO1 Gene

Disorders for IDO1 Gene

(2) University of Copenhagen DISEASES for IDO1 Gene

(73) Novoseek inferred disease relationships for IDO1 Gene

Disease -log(P) Hits PubMed IDs
bladder diseases 47.9 1
inflammation 42.6 31
tumors 42 154
infection chronic 39.1 5
autoimmune diseases 39 9

Relevant External Links for IDO1

Genetic Association Database (GAD)
IDO1
Human Genome Epidemiology (HuGE) Navigator
IDO1
genes like me logo Genes that share disorders with IDO1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IDO1 Gene

Publications for IDO1 Gene

  1. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PMID: 16477023) Sugimoto H. … Shiro Y. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  2. Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PMID: 2109605) Dai W. … Gupta S.L. (Biochem. Biophys. Res. Commun. 1990) 2 3 4
  3. Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PMID: 16842443) Cozzi A. … Moroni F. (J. Viral Hepat. 2006) 3 23 25
  4. Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. (PMID: 2326172) Tone S. … Kido R. (Nucleic Acids Res. 1990) 3 4
  5. Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas. (PMID: 19844741) Liu J. … Cui G. (Virchows Arch. 2009) 3 23

Products for IDO1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Amino Acid Metabolism I in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IDO1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IDO1
    • Block miRNA regulation of IDO1 using miScript Target Protectors

    Sources for IDO1 Gene

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