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IDO1 Gene

protein-coding   GIFtS: 65
GCID: GC08P039771

Indoleamine 2,3-Dioxygenase 1

(Previous name: indoleamine-pyrrole 2,3 dioxygenase)
(Previous symbols: IDO, INDO)
  See IDO1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Indoleamine 2,3-Dioxygenase 11 2     Indoleamine-Pyrrole 2,3 Dioxygenase1
IDO1 2 3 5     Indolamine 2,3 Dioxygenase2
INDO1 2 3 5     Indole 2,3-Dioxygenase2
Indoleamine-Pyrrole 2,3-Dioxygenase2 3     EC
IDO-12 3     

External Ids:    HGNC: 60591   Entrez Gene: 36202   Ensembl: ENSG000001312037   OMIM: 1474355   UniProtKB: P149023   

Export aliases for IDO1 gene to outside databases

Previous GC identifiers: GC08P039891 GC08P038304

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDO1 Gene:
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting
step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates
including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to
play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense,
neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes,
and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino
acid tryptophan.(provided by RefSeq, Feb 2011)

GeneCards Summary for IDO1 Gene:
IDO1 (indoleamine 2,3-dioxygenase 1) is a protein-coding gene. Diseases associated with IDO1 include toxic oil syndrome, and listeriosis. GO annotations related to this gene include electron carrier activity and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO2.

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of

Gene Wiki entry for IDO1 (Indoleamine 2,3-dioxygenase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IDO1 gene promoter:
         GR   AML1a   GR-beta   LUN-1   NF-kappaB   HNF-4alpha1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIDO1 promoter sequence
   Search Chromatin IP Primers for IDO1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p12-p11

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDO1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P039771:  view genomic region     (about GC identifiers)

39,759,794 bp from pter      End:
39,786,309 bp from pter
26,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902 (See protein sequence)
Recommended Name: Indoleamine 2,3-dioxygenase 1  
Size: 403 amino acids; 45326 Da
Cofactor: Binds 1 heme group per subunit
2 PDB 3D structures from and Proteopedia for IDO1:
2D0T (3D)        2D0U (3D)    
Secondary accessions: Q540B4

Explore the universe of human proteins at neXtProt for IDO1: NX_P14902

Explore proteomics data for IDO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IDO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002155.1  
    ENSEMBL proteins: 
     ENSP00000429297   ENSP00000428716   ENSP00000430505   ENSP00000429933   ENSP00000430950  
    Reactome Protein details: P14902

    IDO1 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for IDO1
    OriGene Purified Protein for IDO1
    OriGene Protein Over-expression Lysate for IDO1
    OriGene MassSpec for IDO1
    OriGene Custom Protein Services for IDO1
    GenScript Custom Purified and Recombinant Proteins Services for IDO1
    Novus Biologicals IDO1 Protein
    Novus Biologicals IDO1 Lysates
    Sino Biological Recombinant Protein for IDO1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for IDO1 

    antibodies-online proteins for IDO1 (6 products) 

    antibodies-online peptides for IDO1

    Search GeneTex for Proteins for IDO1 

    IDO1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IDO1
    R&D Systems Antibodies for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
    Cell Signaling Technology (CST) Antibodies for IDO1  (INDO)
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    Abcam antibodies for IDO1
    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for IDO1 (96 products) 

    GeneTex Antibodies for IDO1:  
                        IDO1 Antibodies

    IDO1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IDO1 
    antibodies-online kits for IDO1 (10 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    1 InterPro protein domain:
     IPR000898 Indolamine_dOase

    Graphical View of Domain Structure for InterPro Entry P14902

    ProtoNet protein and cluster: P14902

    1 Blocks protein domain: IPB000898 Indoleamine 2,3-dioxygenase

    UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
    Similarity: Belongs to the indoleamine 2,3-dioxygenase family

    Find genes that share domains with IDO1           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I23O1_HUMAN, P14902
    Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of
    Catalytic activity: D-tryptophan + O(2) = N-formyl-D-kynurenine
    Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine
    Enzyme regulation: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by
    L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan)
    Biophysicochemical properties: Kinetic parameters: KM=21.23 uM for L-tryptophan; KM=4.6 mM for D-tryptophan;
    Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan;
    Induction: By IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004833tryptophan 2,3-dioxygenase activity EXP--
    GO:0005515protein binding ----
    GO:0009055electron carrier activity TAS2109605
    GO:0020037heme binding IEA--
    GO:0033754indoleamine 2,3-dioxygenase activity IEA--
    Find genes that share ontologies with IDO1           About GenesLikeMe

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ido1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with IDO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ido1tm1Alm for IDO1

       genOway: Develop your customized and physiologically relevant rodent model for IDO1

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for IDO1

    Block miRNA regulation of human, mouse, rat IDO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IDO1
    SwitchGear 3'UTR luciferase reporter plasmidIDO1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for IDO1
    Predesigned siRNA for gene silencing in human, mouse, rat IDO1

    OriGene clones in human, mouse for IDO1 (see all 6)
    OriGene ORF clones in mouse, rat for IDO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
    Sino Biological Human cDNA Clone for IDO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for IDO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IDO1 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from COMPARTMENTS: 

    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030485smooth muscle contractile fiber IEA--
    GO:0032421stereocilium bundle IEA--

    Find genes that share ontologies with IDO1           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for IDO1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    Tryptophan metabolism0.46
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    5Lymphocyte Signaling
    Lymphocyte Signaling

    Find genes that share SuperPaths with IDO1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 Cell Signaling Technology (CST) Pathway for IDO1
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for IDO1
        NAD metabolism

    2 BioSystems Pathways for IDO1
        tryptophan degradation via kynurenine
    Tryptophan metabolism

    1 Reactome Pathway for IDO1
        Tryptophan catabolism

    3 Kegg Pathways  (Kegg details for IDO1):
        Tryptophan metabolism
    Metabolic pathways
    African trypanosomiasis

    UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:
    step 1/2

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDO1: 

              Amino Acid Metabolism I in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat


        GeneGlobe Interaction Network for IDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IDO1 (P149022, 3 ENSP000002535134) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3MINT-65182 I2D: score=6 
    DDX24Q9GZR72, 3, ENSP000003286904MINT-65410 I2D: score=5 STRING: ENSP00000328690
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AANATENSP000002506154STRING: ENSP00000250615
    AFMIDENSP000003289384STRING: ENSP00000328938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002534cytokine production involved in inflammatory response IEA--
    GO:0002666positive regulation of T cell tolerance induction IEA--
    GO:0002678positive regulation of chronic inflammatory response IEA--
    GO:0002830positive regulation of type 2 immune response IEA--
    GO:0006569tryptophan catabolic process TAS--

    Find genes that share ontologies with IDO1           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IDO1
      Browse compounds at ApexBio 

    Browse Tocris compounds for IDO1 (I23O1)

    9 HMDB Compounds for IDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-415636586
    5-Hydroxy-L-tryptophan(+-)-5-Hydroxytryptophan (see all 21)4350-09-8--
    5-Hydroxy-N-formylkynurenine ----
    D-Tryptophan(+)-tryptophan (see all 19)153-94-6--
    Formyl-5-hydroxykynurenamine3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole (see all 7)2208-41-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    OxygenOxygen (see all 5)7782-44-7--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    2 DrugBank Compounds for IDO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3enzymesubstrate17417651 16842443 17430109 17015752 11752352 16887964 19290871
    MelatoninMEL (see all 4)73-31-4enzymesubstrate15636586

    Selected Novoseek inferred chemical compound relationships for IDO1 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indoleamine 99.1 465 18612775 (2), 19519465 (2), 17942160 (2), 15063631 (2) (see all 99)
    kynurenine 97.2 292 10756023 (6), 8293279 (5), 19327051 (5), 10731095 (4) (see all 99)
    1-methyltryptophan 95.2 71 18418598 (5), 16887964 (3), 17605849 (2), 17234791 (2) (see all 29)
    1-methyl-d-tryptophan 90.2 14 15281097 (1), 17114500 (1), 18832696 (1), 17945538 (1) (see all 8)
    n-formylkynurenine 88.7 14 8288893 (1), 1591013 (1), 15206718 (1), 19275153 (1) (see all 14)
    3-hydroxyanthranilic acid 84.4 10 11392499 (2), 10731095 (1), 20484731 (1), 11798468 (1) (see all 8)
    l-tryptophan 83.5 56 18639341 (4), 10731095 (3), 19264674 (2), 7814143 (2) (see all 37)
    quinolinic acid 82.5 24 17457312 (2), 18063923 (2), 19958238 (2), 14592780 (1) (see all 20)
    neopterin 81 19 19765856 (2), 15302611 (1), 17136028 (1), 7790043 (1) (see all 17)
    indolamine 80.4 11 10206145 (2), 15516717 (1), 19079205 (1), 17157205 (1) (see all 10)

    2 PharmGKB related drug/compound annotations for IDO1 gene    About this table
    Drug/compound PharmGKB Annotation
    interferon alfa-2a, recombinantCA  
    peginterferon alfa-2bCA  

    Find genes that share compounds with IDO1           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for IDO1 gene: 

    Unigene Cluster for IDO1:

    Indoleamine 2,3-dioxygenase 1
    Hs.840  [show with all ESTs]
    Unigene Representative Sequence: NM_002164
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518804 ENST00000519154 ENST00000522495 ENST00000522840 ENST00000518237(uc003xnm.3)
    ENST00000253513 ENST00000521636 ENST00000521480 ENST00000523779
    Block miRNA regulation of human, mouse, rat IDO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IDO1
    SwitchGear 3'UTR luciferase reporter plasmidIDO1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for IDO1
    Predesigned siRNA for gene silencing in human, mouse, rat IDO1
    OriGene clones in human, mouse for IDO1 (see all 6)
    OriGene ORF clones in mouse, rat for IDO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1
    OriGene qPCR primer pairs and template standards for IDO1
    OriGene qSTAR qPCR primer pairs in human, mouse for IDO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IDO1
      QuantiTect SYBR Green Assays in human, mouse, rat IDO1
      QuantiFast Probe-based Assays in human, mouse, rat IDO1

    Additional mRNA sequence: 

    AK313259.1 AY221100.1 BC027882.1 JF772862.1 M34455.1 X17668.1 

    8 DOTS entries:

    DT.408798  DT.100691410  DT.100788833  DT.65287506  DT.95330370  DT.92018039  DT.92451035  DT.95216114 

    Selected AceView cDNA sequences (see all 86):

    X17668 AL549895 CR613807 BE466403 CB118974 CD369108 CR591703 AU137351 
    CA432661 AA478279 BX113985 CB529600 CR621546 CD742761 AL549011 AA478338 
    AY221100 AI308058 BC027882 NM_002164 CB217134 AL545869 CR616634 AL554455 

    GeneLoc Exon Structure

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    IDO1 Expression
    About this image

    IDO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     Brain (Nervous System)
     Placenta (Extraembryonic Tissues)
    IDO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IDO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.840
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDO1: 
              Amino Acid Metabolism I in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    OriGene qPCR primer pairs and template standards for IDO1
    OriGene qSTAR qPCR primer pairs in human, mouse for IDO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IDO1
    QuantiTect SYBR Green Assays in human, mouse, rat IDO1
    QuantiFast Probe-based Assays in human, mouse, rat IDO1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IDO1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ido11 , 5 indoleamine 2,3-dioxygenase 11, 5 72.24(n)1
      8 (12.76 cM)5
    159301  NM_008324.11  NP_032350.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA2(YJR078W)4
    Putative tryptophan 2,3-dioxygenase or indoleamine more4
    8535411, 4  NP_012612.31  NP_012612.14 

    ENSEMBL Gene Tree for IDO1 (if available)
    TreeFam Gene Tree for IDO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for IDO1 gene
    1 SIMAP similar gene for IDO1 using alignment to 6 protein entries:     I23O1_HUMAN (see all proteins):

    Find genes that share paralogs with IDO1           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for IDO1 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 8 posSequence#AA
    C,F--39773846(+) CAAAAA/CAAAAT 1 -- int11Minor allele frequency- C:0.03NA 120
    F--39773860(+) CCAGCA/GTGTTG 1 -- int12Minor allele frequency- G:0.04CSA WA 119
    C,F--39780923(+) AAAAAA/-AAAAA 1 -- int1 trp32Minor allele frequency- -:0.50NA 4
    C--39780923(+) GTCTC-/AAAAAAA 1 -- int10--------
    C--39781630(+) ATCTG-/CCCTAC 1 -- int10--------
    F--39784436(+) TAACTC/TCCACT 1 -- int11Minor allele frequency- T:0.06WA 118
    F--39840440(+) AGAGCA/CAAACG 1 -- us2k11Minor allele frequency- C:0.05WA 118
    C,F,A,H--39840481(-) CAGGTC/TGTTAT 1 -- us2k124Minor allele frequency- T:0.41NA NS EA WA CSA 1667
    C--39840591(+) TGTAG-/GTAGTATG 1 -- cds10--------
    --39840611(+) AATCAA/TGGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IDO1 (39759794 - 39786309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IDO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658388CNV Deletion23128226
    nsv508505CNV Loss20534489

    Human Gene Mutation Database (HGMD): IDO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IDO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 147435    OMIM disorders: --

    10 diseases for IDO1:    
    About MalaCards
    toxic oil syndrome    listeriosis    trachoma    mediterranean spotted fever
    eosinophilia-myalgia syndrome    bladder disease    scrub typhus    toxoplasmosis
    typhus    malaria

    2 inferred disease relationships from the University of Copenhagen DISEASES database for IDO1:
    eosinophilia-myalgia syndrome     Cancer

    Find genes that share disorders with IDO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IDO1 gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder diseases 47.9 1 17537219 (1)
    inflammation 42.6 34 19155537 (3), 18547472 (2), 18036645 (2), 18063923 (2) (see all 26)
    tumors 42 216 14678522 (7), 19434461 (7), 2116480 (6), 18056175 (6) (see all 87)
    infection chronic 39.1 5 17876564 (1), 17671174 (1), 17767193 (1), 19007906 (1) (see all 5)
    autoimmune diseases 39 9 17430113 (3), 19494274 (1), 15206723 (1), 18660704 (1) (see all 7)
    toxoplasmosis cerebral 37.1 1 8617321 (1)
    necrosis 35.4 27 19935463 (2), 10805371 (1), 15516717 (1), 17457312 (1) (see all 22)
    nuclear cataract 35.2 1 16897708 (1)
    immunodeficiency 34.1 9 16139256 (1), 17626075 (1), 16902147 (1), 17430111 (1) (see all 8)
    autoimmunity 33.5 7 16476191 (1), 19023117 (1), 17360980 (1), 17767193 (1) (see all 5)

    Genetic Association Database (GAD): IDO1
    Human Genome Epidemiology (HuGE) Navigator: IDO1 (5 documents)

    Export disorders for IDO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IDO1 gene, integrated from 10 sources (see all 674) (see top 10):
    (articles sorted by number of sources associating them with IDO1)

    1. Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)1, 2, 3 Dai W. and Gupta S.L. (Biochem. Biophys. Res. Commun. 1990)
    2. Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PubMed id 16842443)1, 7, 9 Cozzi A....Moroni F. (J. Viral Hepat. 2006)
    3. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)1, 2, 9 Sugimoto H.... Shiro Y. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    5. Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (PubMed id 20192952)1, 4 Nishizawa H....Udagawa Y. (Am. J. Reprod. Immunol. 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    8. Evolution of vertebrate indoleamine 2,3-dioxygenases. (PubMed id 18026683)1, 2 Yuasa H.J.... Suzuki T. (J. Mol. Evol. 2007)
    9. Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. (PubMed id 15636586)6, 7 Ferry G....Boutin J.A. (Biochem. J. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    11. Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12--&gt;p11 by fluorescent in situ hybridization. (PubMed id 8404046)1, 3 Najfeld V....Gupta S.L. (Cytogenet. Cell Genet. 1993)
    12. Gene structure of human indoleamine 2,3-dioxygenase. (PubMed id 1449503)1, 2 Kadoya A.... Kido R. (Biochem. Biophys. Res. Commun. 1992)
    13. Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. (PubMed id 2326172)1, 2 Tone S....Kido R. (Nucleic Acids Res. 1990)
    14. IDO inhibits T-cell function through suppressing Vav1 expression and activation. (PubMed id 19597340)1, 9 Li R....Hao X. (amp 2009)
    15. Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. (PubMed id 17626075)1, 9 Suh H.S....Lee S.C. (J. Virol. 2007)
    16. Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. (PubMed id 19155537)1, 9 Schefold J.C....Reinke P. (Nephrol. Dial. Transplant. 2009)
    17. Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer. (PubMed id 19604349)1, 9 Mansfield A.S....Leidenius M.H. (BMC Cancer 2009)
    18. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. (PubMed id 19487045)1, 9 Suzuki Y....Chida K. (Lung Cancer 2010)
    19. The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer. (PubMed id 19695096)1, 9 Gao Y.F....Zhang X.S. (J Transl Med 2009)
    20. Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. (PubMed id 19434461)1, 9 Batista C.E....Chugani D.C. (Mol Imaging Biol 2009)
    21. Indoleamine-dioxygenase is expressed in human decidua at the time maternal tolerance is established. (PubMed id 17321596)1, 9 von Rango U....Classen-Linke I. (J. Reprod. Immunol. 2007)
    22. Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. (PubMed id 19058839)1, 9 Maneechotesuwan K....Wongkajornsilp A. (J. Allergy Clin. Immunol. 2009)
    23. Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. (PubMed id 18299324)1, 9 Maghzal G.J....Stocker R. (J. Biol. Chem. 2008)
    24. Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. (PubMed id 18438685)1, 9 Pan K....Xia J.C. (J. Cancer Res. Clin. Oncol. 2008)
    25. Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses. (PubMed id 16686756)1, 9 Beutelspacher S.C....George A.J. (Am. J. Transplant. 2006)
    26. Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine 2,3-dioxygenase. (PubMed id 15102781)1, 9 Hucke C....DAoubener W. (Infect. Immun. 2004)
    27. Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta. (PubMed id 11912287)1, 9 Sedlmayr P....Dohr G. (Mol. Hum. Reprod. 2002)
    28. Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival. (PubMed id 19448397)1, 9 Brody J.R....Witkiewicz A.K. (Cell Cycle 2009)
    29. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. (PubMed id 17433037)1, 9 Nakamura T....Saito S. (Cancer Sci. 2007)
    30. Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. (PubMed id 16319139)1, 9 Hill M....Anegon I. (FASEB J. 2005)
    31. Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. (PubMed id 16135011)1, 9 Clark D.A....Arck P.C. (Am. J. Reprod. Immunol. 2005)
    32. Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye. (PubMed id 8817290)1, 9 Malina H.Z. and Martin X.D. (Graefes Arch. Clin. Exp. Ophthalmol. 1996)
    33. Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. (PubMed id 19933867)1, 9 Godin-Ethier J....Lapointe R. (J. Immunol. 2009)
    34. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species. (PubMed id 19693771)1, 9 Ogasawara N....Nagase F. (J. Cell. Biochem. 2009)
    35. Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. (PubMed id 17535808)1, 9 Thomas S.R....Stocker R. (J. Biol. Chem. 2007)
    36. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. (PubMed id 15711557)1, 9 Muller A.J....Prendergast G.C. (Nat. Med. 2005)
    37. 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. (PubMed id 16887964)7, 9 AgauguAc S....Lotteau V. (J. Immunol. 2006)
    38. Interactions between nitric oxide and indoleamine 2,3-dioxygenase. (PubMed id 16834326)1, 9 Samelson-Jones B.J. and Yeh S.R. (Biochemistry 2006)
    39. Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy. (PubMed id 15950064)1, 9 Ligam P....Walker D. (Placenta 2005)
    40. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. (PubMed id 14502282)1, 9 Uyttenhove C....Van den Eynde B.J. (Nat. Med. 2003)
    41. The role of indoleamine 2,3-dioxygenase in retinal pigment epithelial cell-mediated immune modulation. (PubMed id 20128646)1, 9 Park C.Y....Park C.G. (Ocul. Immunol. Inflamm. 2010)
    42. Indoleamine 2,3-dioxygenase in lung allograft tolerance. (PubMed id 19783182)1, 9 Meloni F....Fietta A.M. (J. Heart Lung Transplant. 2009)
    43. Increased TTS abrogates IDO-mediated CD4(+) T cells suppression in patients with Graves' disease. (PubMed id 19363598)1, 9 Wang S....Ning G. (Endocrine 2009)
    44. Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients' sera by HPLC and is inducible by IFN-gamma. (PubMed id 18639339)1, 9 Corm S....Quesnel B. (Leuk. Res. 2009)
    45. Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study. (PubMed id 18622801)1, 9 Niinisalo P....Hurme M. (Scand. J. Clin. Lab. Invest. 2008)
    46. Differential immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO) on primary human CD4+ and CD8+ T cells. (PubMed id 18008147)1, 9 Forouzandeh F....Ghahary A. (Mol. Cell. Biochem. 2008)
    47. Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation? (PubMed id 18055547)1, 9 Scheler M....von Bubnoff D. (Am. J. Pathol. 2007)
    48. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. (PubMed id 17192467)1, 9 Sarkar S.A....Hutton J.C. (Diabetes 2007)
    49. Indoleamine 2, 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan. (PubMed id 17605849)1, 9 Sun J.X....Liu S.H. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    50. Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. (PubMed id 16513157)1, 9 Pertovaara M....Hurme M. (Mech. Ageing Dev. 2006)
    51. Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. (PubMed id 15528322)1, 9 Odemuyiwa S.O....Moqbel R. (J. Immunol. 2004)
    52. Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase. (PubMed id 15245429)1, 9 von Bubnoff la Salle H. (J. Invest. Dermatol. 2004)
    53. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. (PubMed id 15001472)1, 9 Meisel R....Dilloo D. (Blood 2004)
    54. Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels. (PubMed id 12963490)1, 9 Grant R. and Kapoor V. (Biochem. Pharmacol. 2003)
    55. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. (PubMed id 20484731)1, 9 Favre D....McCune J.M. (Sci Transl Med 2010)
    56. Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function. (PubMed id 19264674)1, 9 Becerra A....Bosch I. (J. Gen. Virol. 2009)
    57. Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system. (PubMed id 19815714)1, 9 Tulic M.K....Moqbel R. (Am. J. Pathol. 2009)
    58. Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas. (PubMed id 19844741)1, 9 Liu J....Cui G. (Virchows Arch. 2009)
    59. Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. (PubMed id 19290871)7, 9 Rafice S.A....Raven E.L. (Biochem. Soc. Trans. 2009)
    60. Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation. (PubMed id 18660700)1, 9 Brandacher G....Fuchs D. (Curr Opin Organ Transplant 2008)
    61. Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches. (PubMed id 19004406)1, 9 Sebire N.J....Seckl M. (J Reprod Med 2008)
    62. The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. (PubMed id 18832696)1, 9 Chen W....Blazar B.R. (J. Immunol. 2008)
    63. Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids. (PubMed id 18036645)1, 9 Maneechotesuwan K....Barnes P.J. (J. Allergy Clin. Immunol. 2008)
    64. Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells. (PubMed id 18045970)1, 9 Lob S....Terness P. (Blood 2008)
    65. [Indoleamine 2,3-dioxygenase expression in breast cancer patients during chemotherapy]. (PubMed id 19106591)1, 9 Sakurai K....Shiono M. (amp 2008)
    66. Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model. (PubMed id 19010841)1, 9 Yoshida N....Kikkawa F. (Clin. Cancer Res. 2008)
    67. The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2,3-dioxygenase. (PubMed id 18370410)1, 9 Chauhan N....Raven E.L. (Biochemistry 2008)
    68. HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. (PubMed id 17158233)1, 9 Boasso A....Shearer G.M. (Blood 2007)
    69. On watching the watchers: IDO and type I/II IFN. (PubMed id 17393386)1, 9 Puccetti P. (Eur. J. Immunol. 2007)
    70. Tryptophan catabolism in IDO+ plasmacytoid dendritic cells. (PubMed id 17430109)7, 9 Fallarino F....Puccetti P. (Curr. Drug Metab. 2007)
    71. Are indoleamine-2,3-dioxygenase producing human dendritic cells a tool for suppression of allogeneic T-cell responses? (PubMed id 17318080)1, 9 LAPb S....KAPnigsrainer A. (Transplantation 2007)
    72. IL-8 and IDO expression by human gingival fibroblasts via TLRs. (PubMed id 17202379)1, 9 Mahanonda R....Pichyangkul S. (J. Immunol. 2007)
    73. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. (PubMed id 17229698)1, 9 Larrea E....Prieto J. (J. Virol. 2007)
    74. Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. (PubMed id 17911610)1, 9 Cuffy M.C....Tellides G. (J. Immunol. 2007)
    75. Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (PubMed id 17674321)1, 9 de Sousa R....Walker D.H. (J. Infect. Dis. 2007)
    76. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. (PubMed id 17671174)2, 9 Metz R....Prendergast G.C. (Cancer Res. 2007)
    77. A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells. (PubMed id 17294609)1, 9 Zhu W.H....Xiao B.G. (Mult. Scler. 2007)
    78. Crystallization and preliminary crystallographic studies of human indoleamine 2,3-dioxygenase. (PubMed id 16511306)1, 9 Oda S....Shiro Y. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006)
    79. Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells. (PubMed id 16489067)1, 9 Brandacher G....Amberger A. (Clin. Cancer Res. 2006)
    80. Eosinophil granulocytes account for indoleamine 2,3-dioxygenase-mediated immune escape in human non-small cell lung cancer. (PubMed id 15967116)1, 9 Astigiano S....Frumento G. (Neoplasia 2005)
    81. Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon. (PubMed id 15919929)1, 9 Obojes K....Schneider-Schaulies J. (J. Virol. 2005)
    82. IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion. (PubMed id 16421220)1, 9 Miwa N....Saito S. (Mol. Hum. Reprod. 2005)
    83. Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase. (PubMed id 15374002)1, 9 Adams O....DAoubener W. (Microbes Infect. 2004)
    84. Indoleamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells. (PubMed id 14871294)1, 9 Kai S....Kitano S. (Scand. J. Immunol. 2004)
    85. Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. (PubMed id 12766158)1, 9 Littlejohn T.K....Walker M.J. (J. Biol. Chem. 2003)
    86. Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha. (PubMed id 13678429)1, 9 Robinson C.M....Carlin J.M. (amp 2003)
    87. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. (PubMed id 12186837)1, 9 Terness P....Opelz G. (J. Exp. Med. 2002)
    88. Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters. (PubMed id 11180976)1, 9 Takikawa O....Truscott R.J. (Exp. Eye Res. 2001)
    89. Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8. (PubMed id 8406467)1, 9 Burkin D.J....Gupta S.L. (Genomics 1993)
    90. The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells. (PubMed id 24391212)1 Trabanelli S....Lemoli R.M. (J. Immunol. 2014)
    91. Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis. (PubMed id 23200754)1 Tardito S....Filaci G. (Hum. Immunol. 2013)
    92. Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia. (PubMed id 22936460)1 Catani L....Lemoli R.M. (Ann. Hematol. 2013)
    93. Mutation of cysteine residues alters the heme-binding pocket of indoleamine 2,3-dioxygenase-1. (PubMed id 23751345)1 Austin C.J....Jamie J.F. (Biochem. Biophys. Res. Commun. 2013)
    94. Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways. (PubMed id 22913669)1 English K....Wood K.J. (Stem Cells Dev. 2013)
    95. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. (PubMed id 23752227)1 Holmgaard R.B....Allison J.P. (J. Exp. Med. 2013)
    96. Tumoral indoleamine 2,3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma. (PubMed id 23179760)1 Ye J....Li Y. (Virchows Arch. 2013)
    97. Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease. (PubMed id 23651343)1 Bao Y.S....Na S.P. (Biomarkers 2013)
    98. Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation. (PubMed id 22828446)1 Mougiakakos D....Le Blanc K. (Leukemia 2013)
    99. B7 costimulation and intracellular indoleamine-2,3-dioxygenase expression in peripheral blood of healthy pregnant and pre-eclamptic women. (PubMed id 23289444)1 Toldi G....Molvarec A. (Am. J. Reprod. Immunol. 2013)
    100. Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway. (PubMed id 23411497)1 Mei J....Zhu X.Y. (Int J Clin Exp Pathol 2013)
    101. IDO1 metabolites activate I^-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. (PubMed id 23669411)1 Thaker A.I....Ciorba M.A. (Gastroenterology 2013)
    102. In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1. (PubMed id 23358471)1 Zitron I.M....Mittal S. (amp 2013)
    103. Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients. (PubMed id 23620105)1 Sioud M....Kvalheim G. (Int. J. Oncol. 2013)
    104. Indoleamine 2,3-dioxygenase levels at the normal and recurrent spontaneous abortion fetal-maternal interface. (PubMed id 23847296)1 Ban Y....Qu X. (J. Int. Med. Res. 2013)
    105. Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells. (PubMed id 23973990)1 Iachininoto M.G....Rutella S. (Molecules 2013)
    106. Expression of indoleamine 2,3-dioxygenase and correlation with pathological malignancy in gliomas. (PubMed id 23426156)1 Mitsuka K....Kinouchi H. (Neurosurgery 2013)
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    108. Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry. (PubMed id 23344392)1 Soliman H....Ambs S. (Cancer Immunol. Immunother. 2013)
    109. Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. (PubMed id 23440412)1 Yu J....Ren X. (J. Immunol. 2013)
    110. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. (PubMed id 23853597)1 De Luca A....Romani L. (PLoS Pathog. 2013)
    111. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. (PubMed id 22184722)1 Zhao Q....Zheng L. (J. Immunol. 2012)
    112. Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells. (PubMed id 22638210)1 Mei J....Zhu X.Y. (Mol. Hum. Reprod. 2012)
    113. High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma. (PubMed id 21328335)1 Jacquemier J....Xerri L. (Int. J. Cancer 2012)
    114. Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-I+-induced depression in patients with chronic hepatitis C. (PubMed id 21691274)1 Smith A.K....Miller A.H. (Mol. Psychiatry 2012)
    115. Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation. (PubMed id 22923135)1 Sato N....Suzuki M. (Oncol. Rep. 2012)
    116. Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-I_B. (PubMed id 22301793)1 Yeung A.W....Thomas S.R. (J. Leukoc. Biol. 2012)
    117. Indoleamine 2,3-dioxygenase activation and depressive symptoms: results from the Young Finns Study. (PubMed id 22929065)1 Elovainio M....Keltikangas-JAorvinen L. (Psychosom Med 2012)
    118. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. (PubMed id 23232072)1 Bonanno G....Rutella S. (J Transl Med 2012)
    119. The cystine/glutamate antiporter regulates the functional expression of indoleamine 2,3-dioxygenase in human dendritic cells. (PubMed id 22690871)1 D'Angelo J.A....Dickinson B.L. (Scand. J. Immunol. 2012)
    120. Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia. (PubMed id 22526360)1 Xu S.Q....Hou M. (Ann. Hematol. 2012)
    121. Indole peroxygenase activity of indoleamine 2,3-dioxygenase. (PubMed id 22891315)1 Kuo H.H. and Mauk A.G. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    122. IDO in human gut graft-versus-host disease. (PubMed id 21835147)1 Ratajczak P....SociAc G. (Biol. Blood Marrow Transplant. 2012)
    123. Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. (PubMed id 22592557)1 Wolowczuk I....Poulain-Godefroy O. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012)
    124. An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-I^: potential therapeutic use in autoimmune diseases. (PubMed id 22424783)1 Xue Z.T....Widegren B. (Mol. Immunol. 2012)
    125. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins. (PubMed id 22069308)1 Diegelmann J....Brand S. (J. Biol. Chem. 2012)
    126. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. (PubMed id 22751107)1 Kim H....Mao J. (J. Clin. Invest. 2012)
    127. IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. (PubMed id 22932670)1 Wainwright D.A....Lesniak M.S. (Clin. Cancer Res. 2012)
    128. Indoleamine 2,3-dioxygenase expression and functional activity in dendritic cells exposed to cholera toxin. (PubMed id 22519828)1 Slavica L....Eriksson K. (Scand. J. Immunol. 2012)
    129. Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma. (PubMed id 22112045)1 Ninomiya S....Moriwaki H. (amp 2012)
    130. Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity. (PubMed id 21823214)1 Gupta N.K....Ciorba M.A. (Inflamm. Bowel Dis. 2012)
    131. Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi. (PubMed id 22860140)1 Prachason T....Limwongse C. (PLoS Negl Trop Dis 2012)
    132. Induction of indoleamine-2,3 dioxygenase in bone marrow stromal cells inhibits myeloma cell growth. (PubMed id 22722711)1 Pfeifer S....Zojer N. (J. Cancer Res. Clin. Oncol. 2012)
    133. Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. (PubMed id 23090116)1 Blache C.A....Diamond D.J. (Cancer Res. 2012)
    134. Induction of regulatory T Cells by dendritic cells through indoleamine 2,3-dioxygenase: a potent mechanism of acquired peripheral tolerance. (PubMed id 21517756)1 Trabanelli S....Curti A. (Curr. Med. Chem. 2011)
    135. Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity. (PubMed id 21712776)1 Maes M....Rief W. (Neuro Endocrinol. Lett. 2011)
    136. IDO induces expression of a novel tryptophan transporter in mouse and human tumor cells. (PubMed id 21742973)1 Silk J.D....Cerundolo V. (J. Immunol. 2011)
    137. Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP. (PubMed id 20938662)1 Ninomiya S....Moriwaki H. (Ann. Hematol. 2011)
    138. The role of indoleamine 2, 3-dioxygenase in lepromatous leprosy immunosuppression. (PubMed id 21592112)1 de Souza Sales J....Sarno E.N. (Clin. Exp. Immunol. 2011)
    139. Regulation of expression and function of IDO in human dendritic cells. (PubMed id 21517757)1 Heitger A. (Curr. Med. Chem. 2011)
    140. Vascular endothelial expression of indoleamine 2,3-dioxygenase 1 forms a positive gradient towards the feto-maternal interface. (PubMed id 21755000)1 Blaschitz A....Sedlmayr P. (PLoS ONE 2011)
    141. Reduced expression of indoleamine 2,3-dioxygenase participates in pathogenesis of preeclampsia via regulatory T cells. (PubMed id 21461563)1 Liu X....Wang X. (Mol Med Rep 2011)
    142. Ferryl derivatives of human indoleamine 2,3-dioxygenase. (PubMed id 21502325)1 Lu C. and Yeh S.R. (J. Biol. Chem. 2011)
    143. Indoleamine 2,3-dioxygenase is increased in hemodialysis patients and affects immune response to hepatitis B vaccination. (PubMed id 21292009)1 Eleftheriadis T....Galaktidou G. (Vaccine 2011)
    144. Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases. (PubMed id 21517753)1 Prendergast G.C....Muller A.J. (Curr. Med. Chem. 2011)
    145. Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin. (PubMed id 21118329)1 Anderson G. and Rodriguez M. (Eur. J. Neurol. 2011)
    146. Decreased IDO activity and increased TTS expression break immune tolerance in patients with immune thrombocytopenia. (PubMed id 21487895)1 Wang C.Y....Hou M. (J. Clin. Immunol. 2011)
    147. Immunoactivative role of indoleamine 2,3a89dioxygenase in gastric cancer cells in vitro. (PubMed id 21461581)1 Zhang R....Ren X. (Mol Med Rep 2011)
    148. Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study. (PubMed id 21600662)1 Elovainio M....Keltikangas-JAorvinen L. (J Affect Disord 2011)
    149. Is the variant c.422+90G a89 A in intron 4 of indoleamine 2, 3 -dioxygenase (IDO) gene related to age related cataracts? (PubMed id 21617756)1 Mamata M....Padma T. (Mol. Vis. 2011)
    150. Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma. (PubMed id 21692032)1 Kuales M.A....von Bubnoff D. (Histol. Histopathol. 2011)
    151. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    152. Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts. (PubMed id 21952237)1 Wang B....Taketani Y. (Endocrinology 2011)
    153. Coding region polymorphisms in the indoleamine 2,3-dioxygenase (INDO) gene and recurrent spontaneous abortion. (PubMed id 21030093)1 Amani D....Ghaderi A. (J. Reprod. Immunol. 2011)
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    157. Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT. (PubMed id 21355883)1 Zhao X.S....Huang X.J. (Clin Transplant 2011)
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    161. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
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    163. Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma. (PubMed id 22013481)1 Zhang G....Du J. (amp 2011)
    164. Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. (PubMed id 21980470)1 Soichot M....Allorge D. (PLoS ONE 2011)
    165. Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not influencing on the recruitment of FOXP3-expressing regulatory T cells in cancer nests. (PubMed id 21616522)1 Sznurkowski J.J....Biernat W. (Gynecol. Oncol. 2011)
    166. Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis. (PubMed id 22110525)1 Yu J....Ren X. (amp 2011)
    167. Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas. (PubMed id 21501890)1 von Bubnoff D....Wickenhauser C. (J. Am. Acad. Dermatol. 2011)
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    169. Structure and reaction mechanism in the heme dioxygenases. (PubMed id 21361337)1 Efimov I....Raven E.L. (Biochemistry 2011)
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    172. Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (PLoS Negl Trop Dis 2011)
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    174. The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment. (PubMed id 21324164)1 Gold A.B....LanctA't K.L. (J Neuroinflammation 2011)
    175. The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies. (PubMed id 20361220)1 Capece L....Marti M.A. (J. Biol. Inorg. Chem. 2010)
    176. Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. (PubMed id 20689575)1 Kiank C....Schuett C. (PLoS ONE 2010)
    177. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. (PubMed id 20663292)1 Bonda D.J....Smith M.A. (Redox Rep. 2010)
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    179. Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease. (PubMed id 20570568)1 JA1rgens B....Heitger A. (Clin. Immunol. 2010)
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    182. Beyond immunosuppression: reconsidering indoleamine 2,3-dioxygenase as a pathogenic element of chronic inflammation. (PubMed id 20635895)1 Muller A.J....Prendergast G.C. (Immunotherapy 2010)
    183. Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS. (PubMed id 20602605)1 Samikkannu T....Nair M.P. (J. Neurovirol. 2010)
    184. High levels of IDO-expressing CD16+ peripheral cells, and Tregs in graft biopsies from kidney transplant recipients under belatacept treatment. (PubMed id 21094802)1 Furuzawa-Carballeda J....AlberA_ J. (Transplant. Proc. 2010)
    185. Indoleamine 2,3-dioxygenase+ cells correspond to the BDCA2+ plasmacytoid dendritic cells in human melanoma sentinel nodes. (PubMed id 19829303)1 Gerlini G....Borgognoni L. (J. Invest. Dermatol. 2010)
    186. High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death. (PubMed id 20648630)1 Habibi D....Ghahary A. (J. Cell. Physiol. 2010)
    187. A specific interaction of L-tryptophan with CO of CO-bound indoleamine 2,3-dioxygenase identified by resonance Raman spectroscopy. (PubMed id 21028817)1 Yanagisawa S....Ogura T. (Biochemistry 2010)
    188. Local expression of indoleamine 2,3 dioxygenase in syngeneic fibroblasts significantly prolongs survival of an engineered three-dimensional islet allograft. (PubMed id 20522587)1 Jalili R.B....Ghahary A. (Diabetes 2010)
    189. Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma. (PubMed id 19489917)1 Sekigawa T....Inoue I. (Clin. Exp. Allergy 2009)
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    192. Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection. (PubMed id 19306922)1 Krausse-Opatz B....KAPhler L. (Microb. Pathog. 2009)
    193. Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity. (PubMed id 19514129)1 Arefayene M....Skaar T.C. (Pharmacogenet. Genomics 2009)
    194. Indoleamine-2,3-dioxygenase enzyme expression and activity in polarized dendritic cells. (PubMed id 19929471)1 Wolf B....Ernstoff M.S. (Cytotherapy 2009)
    195. Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. (PubMed id 18274832)1 Austin C.J....Hunt N.H. (Amino Acids 2009)
    196. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. (PubMed id 19168733)1 Bourreau E....Launois P. (Infect. Immun. 2009)
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    198. Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase. (PubMed id 19828629)1 Barnes N.A....Doody G.M. (J. Immunol. 2009)
    199. Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. (PubMed id 19465693)1 Chung D.J....Young J.W. (Blood 2009)
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    202. Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma. (PubMed id 19074858)1 Gasparri A.M....Corti A. (Mol. Cancer Ther. 2008)
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    204. High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome. (PubMed id 19050070)1 Chamuleau M.E....Ossenkoppele G.J. (Haematologica 2008)
    205. Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis. (PubMed id 18176870)1 Oertelt-Prigione S....Gershwin M.E. (Autoimmunity 2008)
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    497. Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding. (PubMed id 18783250)9 Thackray S.J....Chapman S.K. (Biochemistry 2008)
    498. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. (PubMed id 17881253)9 Puccetti P. and Fallarino F. (amp 2008)
    499. High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. (PubMed id 18619832)9 Feder-Mengus C....Provenzano M. (Eur. J. Cancer 2008)
    500. Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? (PubMed id 18064486)9 LAPb S. and KAPnigsrainer A. (Langenbecks Arch Surg 2008)
    501. Evolving immunosuppressive microenvironment during human cervical carcinogenesis. (PubMed id 19079205)9 Kobayashi A....Smith-McCune K. (Mucosal Immunol 2008)
    502. Indoleamine 2,3-dioxygenase in materno-fetal interaction. (PubMed id 17430108)9 Sedlmayr P. (Curr. Drug Metab. 2007)
    503. Indoleamine 2,3-dioxygenase in hematopoietic stem cell transplantation. (PubMed id 17430114)9 Hainz U....Heitger A. (Curr. Drug Metab. 2007)
    504. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. (PubMed id 17767193)9 Puccetti P. and Grohmann U. (Nat. Rev. Immunol. 2007)
    505. The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view. (PubMed id 17982903)9 MiA1ller N. and Schwarz M.J. (J. Neural Transm. Suppl. 2007)
    506. Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches. (PubMed id 17303977)9 Prandota J. (Am J Ther 2007)
    507. The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI). (PubMed id 17544834)9 Bieber T. (Immunobiology 2007)
    508. Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infection. (PubMed id 17430111)9 Schroecksnadel K....Fuchs D. (Curr. Drug Metab. 2007)
    509. The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily. (PubMed id 17924666)9 De Laurentis W....Naismith J.H. (Biochemistry 2007)
    510. IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. (PubMed id 17948274)9 Hill M....Anegon I. (Eur. J. Immunol. 2007)
    511. The immunoregulatory function of indoleamine 2, 3 dioxygenase and its application in allotransplantation. (PubMed id 18094439)9 Jalili R.B....Ghahary A. (Iran J Allergy Asthma Immunol 2007)
    512. Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season. (PubMed id 17711489)9 Pertovaara M....Hurme M. (Clin. Exp. Immunol. 2007)
    513. [Immunology in schizophrenic disorders]. (PubMed id 16897051)9 MA1ller N. and Schwarz M.J. (Nervenarzt 2007)
    514. IDO and clinical conditions associated with depressive symptoms. (PubMed id 17430116)9 Kohl C. and Sperner-Unterweger B. (Curr. Drug Metab. 2007)
    515. CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model. (PubMed id 17513732)9 Elpek K.G....Shirwan H. (J. Immunol. 2007)
    516. Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle. (PubMed id 17896864)9 Kaper T....Frommer W.B. (PLoS Biol. 2007)
    517. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. (PubMed id 17191041)9 Weinlich G....Fuchs D. (Dermatology (Basel) 2007)
    518. Differentiation potential of urothelium from patients with benign bladder dysfunction. (PubMed id 17537219)9 Southgate J....Eardley I. (BJU Int. 2007)
    519. Molecules in focus: indoleamine 2,3-dioxygenase. (PubMed id 17320464)9 King N.J. and Thomas S.R. (amp 2007)
    520. Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease. (PubMed id 17362267)9 Torres M.I....RA-os A. (Clin. Exp. Immunol. 2007)
    521. Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. (PubMed id 17715231)9 Boasso A....Chougnet C. (J. Virol. 2007)
    522. Chronic immune activation underlies morbid obesity: is IDO a key player? (PubMed id 17430117)9 Brandacher G....Weiss H.G. (Curr. Drug Metab. 2007)
    523. Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. (PubMed id 17521318)9 Ryan J.M....Mahon B.P. (Clin. Exp. Immunol. 2007)
    524. Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. (PubMed id 17605296)9 Nasef A....Fouillard L. (Gene Expr. 2007)
    525. Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells. (PubMed id 17164341)9 Curti A....Lemoli R.M. (Blood 2007)
    526. The role of indoleamine 2,3-dioxygenase in transplantation. (PubMed id 17239019)9 Hainz U....Heitger A. (Transpl. Int. 2007)
    527. Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase. (PubMed id 17103092)9 Keskin D.B....Gearhart D.A. (amp 2007)
    528. Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study. (PubMed id 17349013)9 Pertovaara M....Hurme M. (Clin. Exp. Immunol. 2007)
    529. Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression. (PubMed id 17195079)9 Wobser M....Becker J.C. (Cancer Immunol. Immunother. 2007)
    530. Tumor immune escape mediated by indoleamine 2,3-dioxygenase. (PubMed id 17644189)9 Zamanakou M....Karanikas V. (Immunol. Lett. 2007)
    531. Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses. (PubMed id 17881247)9 Rouas-Freiss N....Carosella E.D. (Semin. Cancer Biol. 2007)
    532. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. (PubMed id 17360980)9 Ueno A....Yang Y. (Diabetes 2007)
    533. How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation. (PubMed id 17430110)9 Boasso A. and Shearer G.M. (Curr. Drug Metab. 2007)
    534. Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines. (PubMed id 17430112)9 MacKenzie C.R....DAoubener W. (Curr. Drug Metab. 2007)
    535. Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic dendritic cells. (PubMed id 18025190)9 Urzainqui A....SA!nchez-Madrid F. (J. Immunol. 2007)
    536. CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. (PubMed id 16896154)9 Hryniewicz A....Franchini G. (Blood 2006)
    537. Calcium-pterin suppresses mitogen-induced tryptophan degradation and neopterin production in peripheral blood mononuclear cells. (PubMed id 17113915)9 Winkler C....Fuchs D. (Immunobiology 2006)
    538. Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells. (PubMed id 16490253)9 LA^pez A.S....GonzA!lez A. (Mol. Immunol. 2006)
    539. Immune mechanisms of allergen-specific sublingual immunotherapy. (PubMed id 16409190)9 Moingeon P....Van Overtvelt L. (Allergy 2006)
    540. Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients. (PubMed id 16687019)9 Brandacher G....Weiss H.G. (Obes Surg 2006)
    541. Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? (PubMed id 16881731)9 Faal N....Holland M.J. (PLoS Med. 2006)
    542. Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism? (PubMed id 16829304)9 WilczyA8ski J.R. (Hum. Immunol. 2006)
    543. Monitoring tryptophan metabolism in chronic immune activation. (PubMed id 16139256)9 SchrAPcksnadel K....Fuchs D. ( international journal of clinical chemistry 2006)
    544. Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. (PubMed id 17062375)9 Muller N. and Schwarz M. (Neurotox Res 2006)
    545. 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. (PubMed id 16899371)9 Choi B.K....Kwon B.S. (Cytokine 2006)
    546. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. (PubMed id 16420054)9 Gaspari P....Donovan A.M. (J. Med. Chem. 2006)
    547. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. (PubMed id 16527542)9 Wood K.J. and Sawitzki B. (Trends Immunol. 2006)
    548. Regulatory T cell maintenance of dominant tolerance: induction of tissue self-defense? (PubMed id 17157205)9 Oliveira V....Graca L. (Transpl. Immunol. 2006)
    549. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. (PubMed id 16902147)9 Nilsson J....Chougnet C. (Blood 2006)
    550. Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute. (PubMed id 16417228)9 Li Y....Ghahary A. (J. Invest. Dermatol. 2006)
    551. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. (PubMed id 16957024)9 Evans K.N....Hewison M. (Biol. Reprod. 2006)
    552. TNF regulates cellular NAD+ metabolism in primary macrophages. (PubMed id 16516847)9 Iqbal J. and Zaidi M. (Biochem. Biophys. Res. Commun. 2006)
    553. Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. (PubMed id 17114500)9 Zhu L....Zhang Y. (J. Immunol. 2006)
    554. Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. (PubMed id 17192176)9 Mukerji G....Anand P. (BMC Urol 2006)
    555. Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation. (PubMed id 16460921)9 Munn D.H. (Curr. Opin. Immunol. 2006)
    556. Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. (PubMed id 17111046)9 Popov A....Schultze J.L. (J. Clin. Invest. 2006)
    557. Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. (PubMed id 16897708)9 Vottero E....Roberge M. (Biotechnol J 2006)
    558. Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines. (PubMed id 16385630)9 Weber W.P....Spagnoli G.C. (Eur. J. Immunol. 2006)
    559. Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. (PubMed id 17148615)9 Vergote D....Power C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    560. Cytochrome b(5) is a major reductant in vivo of human indoleamine 2,3-dioxygenase expressed in yeast. (PubMed id 16574111)9 Vottero E....Mauk A.G. (FEBS Lett. 2006)
    561. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. (PubMed id 16894392)9 Spalletta G....Robinson R.G. (Mol. Psychiatry 2006)
    562. A high-affinity, tryptophan-selective amino acid transport system in human macrophages. (PubMed id 16997853)9 Seymour R.L....Munn D.H. (J. Leukoc. Biol. 2006)
    563. Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. (PubMed id 16741252)9 Romani L....Puccetti P. (Blood 2006)
    564. Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites. (PubMed id 16468035)9 Harlin H....Gajewski T.F. (Cancer Immunol. Immunother. 2006)
    565. Indoleamine-2,3-dioxygenase modulation of allergic immune responses. (PubMed id 16476191)9 Le A.V. and Broide D.H. (Curr Allergy Asthma Rep 2006)
    566. [Indoleamine 2, 3-dioxygenase activity in acute myeloid leukemia cells contributing to tumor immune escape]. (PubMed id 16800938)9 Tang X.Q....Zou P. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006)
    567. Novel action of indoleamine 2,3-dioxygenase attenuating acute lung allograft injury. (PubMed id 16293800)9 Liu H....Visner G.A. (Am. J. Respir. Crit. Care Med. 2006)
    568. The HPA and immune axes in stress: the involvement of the serotonergic system. (PubMed id 16459240)9 Leonard B.E. (Eur. Psychiatry 2005)
    569. Current concepts of tumor-infiltrating lymphocytes in human malignancies. (PubMed id 16111767)9 Chiou S.H....Hong-Nerng H. (J. Reprod. Immunol. 2005)
    570. Role of human brain microvascular endothelial cells during central nervous system infection. Significance of indoleamine 2,3-dioxygenase in antimicrobial defence and immunoregulation. (PubMed id 16113824)9 Adam R....DAoubener W. (Thromb. Haemost. 2005)
    571. Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients. (PubMed id 16053472)9 Amirkhani A....Bergquist J. (Eur. J. Neurol. 2005)
    572. Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors. (PubMed id 16083346)9 Muller A.J....Prendergast G.C. (Expert Opin. Ther. Targets 2005)
    573. Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. (PubMed id 15718917)9 Pellegrin K....Fuchs D. (Shock 2005)
    574. Role of Indoleamine 2,3-Dioxygenase in Antiviral Activity of Interferon-gamma Against Vaccinia Virus. (PubMed id 16359238)9 Terajima M. and Leporati A.M. (Viral Immunol. 2005)
    575. A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation. (PubMed id 15967784)9 Baban B....Mellor A.L. (Int. Immunol. 2005)
    576. Microparticle-free placentally derived soluble factors downmodulate the response of activated T cells. (PubMed id 16360837)9 Gupta A.K....Hahn S. (Hum. Immunol. 2005)
    577. Enhancement of antimicrobial effects by glucocorticoids. (PubMed id 14624357)9 TA1rck J....DAoubener W. (Med. Microbiol. Immunol. 2005)
    578. Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells. (PubMed id 16118322)9 Marteau F....Communi D. (Blood 2005)
    579. Chronicles in drug discovery. (PubMed id 16034484)9 Khurdayan V. and Cullell-Young M. (amp 2005)
    580. Cytokines and major depression. (PubMed id 15694227)9 Schiepers O.J....Maes M. (amp 2005)
    581. Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden. (PubMed id 15732262)9 Huang Y.M....Link H. (Mult. Scler. 2005)
    582. [Metabolism of tryptophan via the kynurenine pathway in saliva]. (PubMed id 15995595)9 Buczko W....Stokowska W. (Postepy Hig Med Dosw (Online) 2005)
    583. The effect of fluid intake on urinary symptoms in women. (PubMed id 15947624)9 Swithinbank L....Abrams P. (J. Urol. 2005)
    584. Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines. (PubMed id 15780178)9 Hwang S.L....Lin C.L. (Cell Res. 2005)
    585. Lack of microbicidal response in human macrophages infected with Parachlamydia acanthamoebae. (PubMed id 15826869)9 Greub G....Mege J.L. (Microbes Infect. 2005)
    586. Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. (PubMed id 15961516)9 Potula R....Persidsky Y. (Blood 2005)
    587. Tryptophan degradation in patients with gynecological cancer correlates with immune activation. (PubMed id 15896467)9 Schroecksnadel K....Fuchs D. (Cancer Lett. 2005)
    588. Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans. (PubMed id 15512788)9 Bertera S....Trucco M. (Exp. Diabesity Res. 2004)
    589. Expression of indoleamine 2,3-dioxygenase in dermal fibroblasts functions as a local immunosuppressive factor. (PubMed id 15102086)9 Ghahary A....Lin X. (J. Invest. Dermatol. 2004)
    590. Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections. (PubMed id 14963171)9 Adams O....DAoubener W. (J. Virol. 2004)
    591. Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase. (PubMed id 15358362)9 Austin C.J....Jamie J.F. (Protein Expr. Purif. 2004)
    592. The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. (PubMed id 14719046)9 Wichers M.C. and Maes M. (amp 2004)
    593. Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease. (PubMed id 15380529)9 Wolf A.M....Tilg H. (Clin. Immunol. 2004)
    594. Phenotypic characterization of regulatory T cells in the human decidua. (PubMed id 15086404)9 Heikkinen J....Lassila O. (Clin. Exp. Immunol. 2004)
    595. Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO. (PubMed id 15579280)9 Nair M.P....Hewitt R. (J. Neuroimmunol. 2004)
    596. Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. (PubMed id 15541637)9 Ito M....Ra C. (J. Dermatol. Sci. 2004)
    597. Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits. (PubMed id 15530458)9 Allegri G....Bertazzo A. ( international journal of clinical chemistry 2004)
    598. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. (PubMed id 15302611)9 Frick B....Fuchs D. (Clin. Biochem. 2004)
    599. IDO and tolerance to tumors. (PubMed id 14720581)9 Munn D.H. and Mellor A.L. (Trends Mol Med 2004)
    600. Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. (PubMed id 15056470)9 Miller C.L....Weis S. (Neurobiol. Dis. 2004)
    601. Predominant contribution of IFN-beta expression to apoptosis induction in human uterine cervical fibroblast cells by influenza-virus infection. (PubMed id 15516717)9 Ohyama K....Toyoda H. (amp 2004)
    602. Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structure. (PubMed id 15109246)9 Aitken J.B....Lay P.A. (Biochemistry 2004)
    603. Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC. (PubMed id 15158610)9 Wirleitner B....Fuchs D. (Immunol. Lett. 2004)
    604. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. (PubMed id 15254594)9 Hayashi T....Raz E. (J. Clin. Invest. 2004)
    605. Tryptophan degradation during and after gestation. (PubMed id 15206718)9 SchrAPcksnadel K....Fuchs D. (Adv. Exp. Med. Biol. 2003)
    606. Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin. (PubMed id 15206719)9 Manuelpillai U....Walker D. (Adv. Exp. Med. Biol. 2003)
    607. Longitudinal study of tryptophan degradation during and after pregnancy. (PubMed id 12479977)9 SchrAPcksnadel K....Fuchs D. (Life Sci. 2003)
    608. Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix. (PubMed id 15206720)9 Sedlmayr P....Dohr G. (Adv. Exp. Med. Biol. 2003)
    609. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. (PubMed id 14592780)9 Myint A.M. and Kim Y.K. (Med. Hypotheses 2003)
    610. Tryptophan catabolism and T cell responses. (PubMed id 15206713)9 Mellor A.L....Baban B. (Adv. Exp. Med. Biol. 2003)
    611. Phenotypic characterization of human decidual macrophages. (PubMed id 12605704)9 Heikkinen J....Lassila O. (Clin. Exp. Immunol. 2003)
    612. Quinolinic acid in the pathogenesis of Alzheimer's disease. (PubMed id 15206729)9 Guillemin G.J....Brew B.J. (Adv. Exp. Med. Biol. 2003)
    613. Comparison of the sequences of Turbo and Sulculus indoleamine dioxygenase-like myoglobin genes. (PubMed id 12711393)9 Suzuki T....Yuasa H.J. (Gene 2003)
    614. Increased degradation of tryptophan in blood of patients with rheumatoid arthritis. (PubMed id 12966593)9 Schroecksnadel K....Fuchs D. (J. Rheumatol. 2003)
    615. At the innate frontiers between mother and fetus: linking abortion with complement activation. (PubMed id 12594944)9 Caucheteux S.M....Ojcius D.M. (Immunity 2003)
    616. Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection. (PubMed id 15206745)9 Neurauter G....Fuchs D. (Adv. Exp. Med. Biol. 2003)
    617. Tryptophan as a link between psychopathology and somatic states. (PubMed id 12883120)9 Russo S....Korf J. (Psychosom Med 2003)
    618. Comparative effects of L-tryptophan and 1-methyl-tryptophan on immunoregulation induced by sperm, human pre-implantation embryo and trophoblast supernatants. (PubMed id 14672333)9 GutiAcrrez G....Markert U.R. (Am. J. Reprod. Immunol. 2003)
    619. Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens. (PubMed id 15206741)9 Takikawa O....Miwa S. (Adv. Exp. Med. Biol. 2003)
    620. [A new mechanism of tumor resistance to the immune system, based on tryptophan breakdown by indoleamine 2,3-dioxygenase]. (PubMed id 15132006)9 Van den Eynde B. (Bull. Mem. Acad. R. Med. Belg. 2003)
    621. Expression of the kynurenine pathway enzymes in human microglia and macrophages. (PubMed id 15206722)9 Guillemin G.J....Brew B.J. (Adv. Exp. Med. Biol. 2003)
    622. Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma. (PubMed id 14563947)9 Lee J.R....Munn D.H. ( a journal of technical methods and pathology 2003)
    623. Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. (PubMed id 12871129)9 Wirleitner B....Fuchs D. (Curr. Med. Chem. 2003)
    624. A beta 1-42 induces production of quinolinic acid by human macrophages and microglia. (PubMed id 14663182)9 Guillemin G.J....Brew B.J. (Neuroreport 2003)
    625. Proliferation of peripheral blood mononuclear cells is suppressed by the indoleamine 2,3-dioxygenase expression of interferon-gamma-treated skin cells in a co-culture system. (PubMed id 12950637)9 Sarkhosh K....Ghahary A. (Wound Repair Regen 2003)
    626. FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses. (PubMed id 12165503)9 von Bubnoff D....Bieber T. (J. Immunol. 2002)
    627. Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains. (PubMed id 12414962)9 Burudi E.M....Fox H.S. (J. Virol. 2002)
    628. Lens epithelial cell apoptosis and intracellular Ca2+ increase in the presence of xanthurenic acid. (PubMed id 11934353)9 Malina H....Hess O.M. (BMC Ophthalmol 2002)
    629. HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity. (PubMed id 11985668)9 Logan G.J....Alexander I.E. (Immunology 2002)
    630. Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase. (PubMed id 11571701)9 Schroten H....DAoubener W. (Neuropediatrics 2001)
    631. 3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma. (PubMed id 11392499)9 Morita T....Seishima M. (Ann. Clin. Biochem. 2001)
    632. IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment. (PubMed id 11798468)9 Guillemin G.J....Brew B.J. (amp 2001)

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    Entrez Gene: 3620 HGNC: 6059 AceView: INDO Ensembl:ENSG00000131203 euGenes: HUgn3620
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for IDO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IDO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IDO1 gene:
    Search GeneIP for patents involving IDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
    CRISPR knockouts from OriGene)
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      GeneTex Antibodies for IDO1: IDO1 Antibodies
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