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IDO1 Gene

protein-coding GIFtS: 65
GCID: GC08P039771

Indoleamine 2,3-Dioxygenase 1

(Previous name: indoleamine-pyrrole 2,3 dioxygenase)
(Previous symbols: IDO, INDO)

See IDO1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Indoleamine 2,3-Dioxygenase 1¹ ²		Indoleamine-Pyrrole 2,3 Dioxygenase¹
IDO¹ ² ³ ⁵		Indolamine 2,3 Dioxygenase²
INDO¹ ² ³ ⁵		Indole 2,3-Dioxygenase²
Indoleamine-Pyrrole 2,3-Dioxygenase² ³		EC 1.13.11.52³
IDO-1² ³

External Ids:	HGNC: 6059¹	Entrez Gene: 3620²	Ensembl: ENSG00000131203⁷	OMIM: 147435⁵	UniProtKB: P14902³

Export aliases for IDO1 gene to outside databases

Previous GC identifers: GC08P039891 GC08P038304

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IDO1 Gene:

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting

step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates

including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to

play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense,

neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes,

and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino

acid tryptophan.(provided by RefSeq, Feb 2011)

GeneCards Summary for IDO1 Gene:

IDO1 (indoleamine 2,3-dioxygenase 1) is a protein-coding gene. Diseases associated with IDO1 include toxic oil syndrome, and listeriosis. GO annotations related to this gene include electron carrier activity and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO2.

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of

oxygen

Gene Wiki entry for IDO1 (Indoleamine 2,3-dioxygenase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NC_018919.2 NT_167187.2

Regulatory elements:

Regulatory transcription factor binding sites in the IDO1 gene promoter:
GR AML1a GR-beta LUN-1 NF-kappaB HNF-4alpha1 GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IDO1 promoter sequence

Search Chromatin IP Primers for IDO1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p12-p11

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDO1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039771: view genomic region (about GC identifiers)

Start:	39,759,794 bp from pter	End:	39,786,309 bp from pter
Size:	26,516 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902 (See protein sequence)

Recommended Name: Indoleamine 2,3-dioxygenase 1

Size: 403 amino acids; 45326 Da

Cofactor: Binds 1 heme group per subunit

2 PDB 3D structures from and Proteopedia for IDO1:

2D0T (3D)

2D0U (3D)

Secondary accessions: Q540B4

Explore the universe of human proteins at neXtProt for IDO1: NX_P14902

Explore proteomics data for IDO1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See IDO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002155.1

ENSEMBL proteins:

ENSP00000429297 ENSP00000428716 ENSP00000430505 ENSP00000429933 ENSP00000430950

ENSP00000253513

Reactome Protein details: P14902

IDO1 Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.
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	antibodies-online proteins for IDO1 (6 products)
	antibodies-online peptides for IDO1

IDO1 Antibody Products:

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IDO1 Assay Products:

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	Search eBioscience for ELISAs for IDO1
	antibodies-online kits for IDO1 (10 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR000898 Indolamine_dOase

Graphical View of Domain Structure for InterPro Entry P14902

ProtoNet protein and cluster: P14902

1 Blocks protein domain: IPB000898 Indoleamine 2,3-dioxygenase

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Similarity: Belongs to the indoleamine 2,3-dioxygenase family

Find genes that share domains with IDO1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: I23O1_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of

oxygen

Catalytic activity: D-tryptophan + O(2) = N-formyl-D-kynurenine

Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

Enzyme regulation: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by

L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan)

Biophysicochemical properties: Kinetic parameters: KM=21.23 uM for L-tryptophan; KM=4.6 mM for D-tryptophan;

Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan;

Induction: By IFNG/IFN-gamma

Enzyme Number (IUBMB): EC 1.13.11.52¹

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004833	tryptophan 2,3-dioxygenase activity	EXP	--
GO:0005515	protein binding	--	--
GO:0009055	electron carrier activity	TAS	2109605
GO:0020037	heme binding	IEA	--
GO:0033754	indoleamine 2,3-dioxygenase activity	IEA	--

Find genes that share ontologies with IDO1 About GenesLikeMe

Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ido1):

cellular

hematopoietic system

homeostasis/metabolism

immune system

reproductive system

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Animal Models:
MGI mouse knock-out Ido1^tm1Alm for IDO1

genOway: Develop your customized and physiologically relevant rodent model for IDO1

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for IDO1

Clone Products:		OriGene clones in human, mouse for IDO1 (see all 6) OriGene ORF clones in mouse, rat for IDO1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for IDO1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
extracellular	2
nucleus	2
cytoskeleton	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0030485	smooth muscle contractile fiber	IEA	--
GO:0032421	stereocilium bundle	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IDO1 About (see all 6)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Tryptophan metabolism

	Tryptophan metabolism	0.46			Tryptophan catabolism	0.00
	Tryptophan metabolism	0.46

Metabolism

Metabolism

0.38

Metabolic pathways

0.38

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

tryptophan degradation via kynurenine

0.00

Nicotinate and nicotinamide metabolism

NAD metabolism

0.43

Lymphocyte Signaling

Lymphocyte Signaling

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Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for IDO1

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for IDO1

NAD metabolism

2 BioSystems Pathways for IDO1

	tryptophan degradation via kynurenine
	Tryptophan metabolism

1 Reactome Pathway for IDO1

Tryptophan catabolism

3 Kegg Pathways (Kegg details for IDO1):

	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:

step 1/2

Pathway & Disease-focused RT² Profiler PCR Arrays including IDO1:

Amino Acid Metabolism I in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Interactions:

GeneGlobe Interaction Network for IDO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for IDO1 (P14902^{2, 3} ENSP00000253513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R16A	Q96I34²^,³	MINT-65182 I2D: score=6
DDX24	Q9GZR7²^,³, ENSP00000328690⁴	MINT-65410 I2D: score=5 STRING: ENSP00000328690
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
AANAT	ENSP00000250615⁴	STRING: ENSP00000250615
AFMID	ENSP00000328938⁴	STRING: ENSP00000328938

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Gene Ontology (GO): Selected biological process terms (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002534	cytokine production involved in inflammatory response	IEA	--
GO:0002666	positive regulation of T cell tolerance induction	IEA	--
GO:0002678	positive regulation of chronic inflammatory response	IEA	--
GO:0002830	positive regulation of type 2 immune response	IEA	--
GO:0006569	tryptophan catabolic process	TAS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IDO1

Browse compounds at ApexBio

Browse Tocris compounds for IDO1 (I23O1)

9 HMDB Compounds for IDO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	15636586
5-Hydroxy-L-tryptophan	(+-)-5-Hydroxytryptophan (see all 21)	4350-09-8	--
5-Hydroxy-N-formylkynurenine		--	--
D-Tryptophan	(+)-tryptophan (see all 19)	153-94-6	--
Formyl-5-hydroxykynurenamine	3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole (see all 7)	2208-41-5	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
L-Tryptophan	(-)-tryptophan (see all 53)	73-22-3	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--

2 DrugBank Compounds for IDO1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Tryptophan	(-)-Tryptophan (see all 14)	73-22-3	enzyme	substrate	17417651 16842443 17430109 17015752 11752352 16887964 19290871
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate	15636586

Selected Novoseek inferred chemical compound relationships for IDO1 gene (see all 57) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
indoleamine	99.1	465	18612775 (2), 19519465 (2), 17942160 (2), 15063631 (2) (see all 99)
kynurenine	97.2	292	10756023 (6), 8293279 (5), 19327051 (5), 10731095 (4) (see all 99)
1-methyltryptophan	95.2	71	18418598 (5), 16887964 (3), 17605849 (2), 17234791 (2) (see all 29)
1-methyl-d-tryptophan	90.2	14	15281097 (1), 17114500 (1), 18832696 (1), 17945538 (1) (see all 8)
n-formylkynurenine	88.7	14	8288893 (1), 1591013 (1), 15206718 (1), 19275153 (1) (see all 14)
3-hydroxyanthranilic acid	84.4	10	11392499 (2), 10731095 (1), 20484731 (1), 11798468 (1) (see all 8)
l-tryptophan	83.5	56	18639341 (4), 10731095 (3), 19264674 (2), 7814143 (2) (see all 37)
quinolinic acid	82.5	24	17457312 (2), 18063923 (2), 19958238 (2), 14592780 (1) (see all 20)
neopterin	81	19	19765856 (2), 15302611 (1), 17136028 (1), 7790043 (1) (see all 17)
indolamine	80.4	11	10206145 (2), 15516717 (1), 19079205 (1), 17157205 (1) (see all 10)

2 PharmGKB related drug/compound annotations for IDO1 gene About this table

Drug/compound	PharmGKB Annotation
interferon alfa-2a, recombinant	CA
peginterferon alfa-2b	CA

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IDO1 gene:

NM_002164.5

Unigene Cluster for IDO1:

Indoleamine 2,3-dioxygenase 1

Hs.840 [show with all ESTs]

Unigene Representative Sequence: NM_002164

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000518804 ENST00000519154 ENST00000522495 ENST00000522840 ENST00000518237(uc003xnm.3)

ENST00000253513 ENST00000521636 ENST00000521480 ENST00000523779

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		QuantiFast Probe-based Assays in human, mouse, rat IDO1

Additional mRNA sequence:

AK313259.1 AY221100.1 BC027882.1 JF772862.1 M34455.1 X17668.1

8 DOTS entries:

DT.408798 DT.100691410 DT.100788833 DT.65287506 DT.95330370 DT.92018039 DT.92451035 DT.95216114

Selected AceView cDNA sequences (see all 86):

X17668 AL549895 CR613807 BE466403 CB118974 CD369108 CR591703 AU137351

CA432661 AA478279 BX113985 CB529600 CR621546 CD742761 AL549011 AA478338

AY221100 AI308058 BC027882 NM_002164 CB217134 AL545869 CR616634 AL554455

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IDO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGAAGATATA

About this image

IDO1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 4 entries
Human embryonic stem cells (family)

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Brain (Nervous System)
Striatum

Placenta (Extraembryonic Tissues)

IDO1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

IDO1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.840

Pathway & Disease-focused RT² Profiler PCR Arrays including IDO1:

Amino Acid Metabolism I in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for IDO1 OriGene qSTAR qPCR primer pairs in human, mouse for IDO1
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		QuantiFast Probe-based Assays in human, mouse, rat IDO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO1 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ido1^{1 , 5}	indoleamine 2,3-dioxygenase 1^{1, 5}	72.24(n)¹ 62.53(a)¹		8 (12.76 cM)⁵ 15930¹ NM_008324.1¹ NP_032350.1¹ 24584136⁵
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	BNA2(YJR078W)⁴ BNA2¹	Putative tryptophan 2,3-dioxygenase or indoleamine more⁴ BNA2¹	45(n)¹ 35.29(a)¹		10(578860-580221)⁴ 853541^{1, 4} NP_012612.3¹ NP_012612.1⁴

ENSEMBL Gene Tree for IDO1 (if available)
TreeFam Gene Tree for IDO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IDO1 gene

IDO2²

1 SIMAP similar gene for IDO1 using alignment to 6 protein entries: I23O1_HUMAN (see all proteins):

IDO2

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72643904^1,2	C,F	--	39773846(+)	`CAAAAA/CAAAAT`	1	--	int¹		1		NA	120
rs112923421^1,2	F	--	39773860(+)	`CCAGCA/GTGTTG`	1	--	int¹		2		CSA WA	119
rs11337517^1,2	C,F	--	39780923(+)	`AAAAAA/-AAAAA`	1	--	int¹ trp³		2		NA	4
rs67116979^1,2	C	--	39780923(+)	`GTCTC-/AAAAAAA`	1	--	int¹		0	--	--	--	--
rs78879167^1,2	C	--	39781630(+)	`ATCTG-/CCCTAC`	1	--	int¹		0	--	--	--	--
rs74893114^1,2	F	--	39784436(+)	`TAACTC/TCCACT`	1	--	int¹		1		WA	118
rs114801633^1,2	F	--	39840440(+)	`AGAGCA/CAAACG`	1	--	us2k¹		1		WA	118
rs3808606^1,2	C,F,A,H	--	39840481(-)	`CAGGTC/TGTTAT`	1	--	us2k¹		24		NA NS EA WA CSA	1667
rs144250506^1,2	C	--	39840591(+)	`TGTAG-/GTAGTATG`	1	--	cds¹		0	--	--	--	--
rs144466883^1,2		--	39840611(+)	`AATCAA/TGGTGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IDO1 (39759794 - 39786309 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for IDO1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2658388	CNV	Deletion	23128226
nsv508505	CNV	Loss	20534489

Human Gene Mutation Database (HGMD): IDO1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IDO1

DNA2.0 Custom Variant and Variant Library Synthesis for IDO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147435 OMIM disorders: --

10 diseases for IDO1:
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toxic oil syndrome listeriosis trachoma mediterranean spotted fever

eosinophilia-myalgia syndrome bladder disease scrub typhus toxoplasmosis

typhus malaria

2 inferred disease relationships from the University of Copenhagen DISEASES database for IDO1:

eosinophilia-myalgia syndrome Cancer

Find genes that share disorders with IDO1 About GenesLikeMe

Selected Novoseek inferred disease relationships for IDO1 gene (see all 73) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder diseases	47.9	1	17537219 (1)
inflammation	42.6	34	19155537 (3), 18547472 (2), 18036645 (2), 18063923 (2) (see all 26)
tumors	42	216	14678522 (7), 19434461 (7), 2116480 (6), 18056175 (6) (see all 87)
infection chronic	39.1	5	17876564 (1), 17671174 (1), 17767193 (1), 19007906 (1) (see all 5)
autoimmune diseases	39	9	17430113 (3), 19494274 (1), 15206723 (1), 18660704 (1) (see all 7)
toxoplasmosis cerebral	37.1	1	8617321 (1)
necrosis	35.4	27	19935463 (2), 10805371 (1), 15516717 (1), 17457312 (1) (see all 22)
nuclear cataract	35.2	1	16897708 (1)
immunodeficiency	34.1	9	16139256 (1), 17626075 (1), 16902147 (1), 17430111 (1) (see all 8)
autoimmunity	33.5	7	16476191 (1), 19023117 (1), 17360980 (1), 17767193 (1) (see all 5)

Genetic Association Database (GAD): IDO1
Human Genome Epidemiology (HuGE) Navigator: IDO1 (5 documents)

Export disorders for IDO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IDO1 gene, integrated from 10 sources (see all 674):
(articles sorted by number of sources associating them with IDO1)

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Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)^{1, 2, 3} Dai W. and Gupta S.L. (Biochem. Biophys. Res. Commun. 1990)
Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PubMed id 16842443)^{1, 7, 9} Cozzi A....Moroni F. (J. Viral Hepat. 2006)
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)^{1, 2, 9} Sugimoto H.... Shiro Y. (Proc. Natl. Acad. Sci. U.S.A. 2006)
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (PubMed id 20192952)^{1, 4} Nishizawa H....Udagawa Y. (Am. J. Reprod. Immunol. 2010)
Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)^{1, 4} Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)^{1, 4} O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
Evolution of vertebrate indoleamine 2,3-dioxygenases. (PubMed id 18026683)^{1, 2} Yuasa H.J.... Suzuki T. (J. Mol. Evol. 2007)
Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. (PubMed id 15636586)^{6, 7} Ferry G....Boutin J.A. (Biochem. J. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3620	HGNC: 6059	AceView: INDO	Ensembl:ENSG00000131203	euGenes: HUgn3620
ECgene: IDO1	Kegg: 3620	H-InvDB: IDO1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IDO1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IDO1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for IDO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IDO1 gene:
Search GeneIP for patents involving IDO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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IDO1 Gene

Indoleamine 2,3-Dioxygenase 1

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IDO1 Gene

Indoleamine 2,3-Dioxygenase 1

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