Aliases for IDO1 Gene
Aliases for IDO1 Gene
External Ids for IDO1 Gene
- HGNC: 6059
- Entrez Gene: 3620
- Ensembl: ENSG00000131203
- OMIM: 147435
- UniProtKB: P14902
Previous HGNC Symbols for IDO1 Gene
- IDO
- INDO
Previous GeneCards Identifiers for IDO1 Gene
- GC08P039771
- GC08P038304
Summaries for IDO1 Gene
-
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
GeneCards Summary for IDO1 Gene
IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include Listeriosis and Bladder Disease. Among its related pathways are superpathway of tryptophan utilization and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include heme binding and tryptophan 2,3-dioxygenase activity. An important paralog of this gene is IDO2.
UniProtKB/Swiss-Prot for IDO1 Gene
-
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
Additional gene information for IDO1 Gene
- Monarch Initiative
- Search for IDO1 at DataMed
- Search for IDO1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDO1 Gene
Genomics for IDO1 Gene
GeneHancer (GH) Regulatory Elements for IDO1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08I039914 | Promoter | 0.8 | EPDnew | 550.4 | +11.6 | 11563 | 0.1 | BCL11A IKZF1 JUNB IKZF2 RUNX3 | ENSG00000253838 IDO1 LOC100420944 ENSG00000253939 TCIM | |
GH08I039913 | Promoter | 0.6 | EPDnew | 550.4 | +11.1 | 11076 | 0.1 | CEBPG | ENSG00000253838 IDO1 ENSG00000253939 LOC100420944 TCIM | |
GH08I039901 | Enhancer | 0.4 | ENCODE | 550.8 | +0.2 | 197 | 1 | POLR2A POU5F1 SIN3A | IDO1 ENSG00000253838 | |
GH08I039947 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 16.3 | +48.1 | 48124 | 4.8 | HDAC1 PKNOX1 ATF1 NFRKB YY1 TCF12 GATA2 ATF7 ETV6 IKZF2 | IDO1 ENSG00000253939 LOC100420944 ENSG00000254287 PIR34651 IDO2 LOC100420480 | |
GH08I039946 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 17.2 | +41.8 | 41841 | 1 | MEIS2 PKNOX1 ZNF740 CAVIN1 NR4A1 TEAD2 PYGO2 GTF2A2 ZNF592 IRF9 | IDO1 ENSG00000254287 ENSG00000253939 LOC100420944 IDO2 LOC100420480 PIR34651 |
- Top Transcription factor binding sites by QIAGEN in the IDO1 gene promoter:
Regulatory Element Products
Genomic Locations for IDO1 Gene
- chr8:39,902,275-39,928,790
- (GRCh38/hg38)
- Size:
- 26,516 bases
- Orientation:
- Plus strand
- chr8:39,759,794-39,786,309
- (GRCh37/hg19)
Genomic View for IDO1 Gene
- Cytogenetic band:
-
- 8p11.21 by Ensembl
- 8p11.21 by Entrez Gene
- 8p11.21 by HGNC


RefSeq DNA sequence for IDO1 Gene
Proteins for IDO1 Gene
-
Protein details for IDO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14902-I23O1_HUMAN
- Recommended name:
- Indoleamine 2,3-dioxygenase 1
- Protein Accession:
- P14902
- E5RGR8
- F6M9T7
- Q540B4
Protein attributes for IDO1 Gene
- Size:
- 403 amino acids
- Molecular mass:
- 45326 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
-
- Monomer.
- Miscellaneous:
-
- Elevated IDO1 expression is a hallmark of major viral infections including HIV, HBV, HCV or influenza and also of major bacteria infections, such as Tb, CAP, listeriosis and sepsis. Depletion of tryptophan and production of tryptophan metabolites with bactericidal activity are important as direct anti-pathogen mechanisms. Pathogens are able to highjack the immunosuppressive effects of IDO1 and make use of them to facilitate their own life cycle.
- IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50% of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598). IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548). Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090). IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.
- IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
- SequenceCaution:
-
- Sequence=AC007991; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for IDO1 Gene
Post-translational modifications for IDO1 Gene
Other Protein References for IDO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
-
Custom Antibody ServicesOriGene Antibodies for IDO1
- Novus Biologicals Antibodies for IDO1
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Abcam antibodies for IDO1
-
Cloud-Clone Corp. Antibodies for IDO1
- Invitrogen Antibodies for IDO1
- antibodies-online: Search results for 190 available IDO1 Antibodies ranked by validation data
- Compare Top IDO1 Antibodies
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Recommended
- 110 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- GeneTex IDO1 antibody for IDO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IDO1
- Sino Biological Antibodies for IDO1
Protein Products
- R&D Systems Proteins and Enzymes for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
-
OriGene Purified Proteins for IDO1
- Search Origene for MassSpec and Protein Over-expression Lysates for IDO1
- Origene Custom Protein Services for IDO1
- Sino Biological Recombinant Proteins for IDO1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IDO1
-
Cloud-Clone Corp. Proteins for IDO1
- Search GeneTex for Proteins for IDO1
-
ProSci Proteins for IDO1
-
Abcam proteins for IDO1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
-
Cloud-Clone Corp. Assay Kits for IDO1
No data available for DME Specific Peptides for IDO1 Gene
Domains & Families for IDO1 Gene
Gene Families for IDO1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for IDO1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IDO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P14902- Family:
-
- Belongs to the indoleamine 2,3-dioxygenase family.
Function for IDO1 Gene
Molecular function for IDO1 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=21.23 uM for L-tryptophan {ECO:0000269 PubMed:18026683}; KM=4.6 mM for D-tryptophan {ECO:0000269 PubMed:18026683}; Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan.;
- UniProtKB/Swiss-Prot CatalyticActivity:
- D-tryptophan + O(2) = N-formyl-D-kynurenine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-tryptophan + O(2) = N-formyl-L-kynurenine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan).
- UniProtKB/Swiss-Prot Function:
- Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
- UniProtKB/Swiss-Prot Induction:
- By IFNG/IFN-gamma in most cells (PubMed:2109605, PubMed:1907934). Exogenous inflammatory stimuli induce the expression of IDO1 in antigen-presenting cells such as dendritic cells, macrophages and B-cells (PubMed:25157255).
Enzyme Numbers (IUBMB) for IDO1 Gene
Phenotypes From GWAS Catalog for IDO1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004833 | tryptophan 2,3-dioxygenase activity | EXP,IEA | 16477023 |
GO:0009055 | electron transfer activity | TAS | 2109605 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO:0033754 | indoleamine 2,3-dioxygenase activity | IMP | 25310899 |
Phenotypes for IDO1 Gene
- MGI mutant phenotypes for IDO1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IDO1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IDO1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IDO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IDO1 gene
- Search ViGene Biosciences for IDO1
CRISPR Products
-
OriGene CRISPR knockouts for IDO1
- genomics-online: gRNA clones - Search results for available IDO1 gene related products
- Applied Biological Materials CRISPR for IDO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDO1
- GenScript: Design CRISPR guide RNA sequences for IDO1
miRNA for IDO1 Gene
- miRTarBase miRNAs that target IDO1
miRNA Products
- Search ViGene Biosciences for IDO1
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for IDO1
- Browse OriGene Inhibitory RNA Products For IDO1
- genomics-online: shRNA clones - Search results for available IDO1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IDO1 gene
Clone Products
- Sino Biological Human cDNA Clone for IDO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IDO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IDO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available IDO1 gene related products
- orf clones - Search results for available IDO1 gene related products
- Applied Biological Materials Clones for IDO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
Cell Line Products
-
Horizon Cell Lines for IDO1
-
ViGene Biosciences adenoviral particle packaged cDNA for IDO1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IDO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IDO1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IDO1 Gene
Localization for IDO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IDO1 Gene
- Cytoplasm, cytosol.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0030485 | smooth muscle contractile fiber | IEA | -- |
GO:0032421 | stereocilium bundle | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IDO1 Gene
Pathways & Interactions for IDO1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
2 | superpathway of tryptophan utilization | ||
3 | Metabolism |
.37
|
|
4 | NAD metabolism |
.42
|
|
5 | African trypanosomiasis |
Pathways by source for IDO1 Gene
2 Cell Signaling Technology pathways for IDO1 Gene
7 BioSystems pathways for IDO1 Gene
3 KEGG pathways for IDO1 Gene
1 GeneGo (Thomson Reuters) pathway for IDO1 Gene
UniProtKB/Swiss-Prot P14902-I23O1_HUMAN
- Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Interacting Proteins for IDO1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0002534 | cytokine production involved in inflammatory response | IEA | -- |
GO:0002666 | positive regulation of T cell tolerance induction | IEA | -- |
GO:0002678 | positive regulation of chronic inflammatory response | IEA | -- |
GO:0002830 | positive regulation of type 2 immune response | IEA | -- |
No data available for SIGNOR curated interactions for IDO1 Gene
Drugs & Compounds for IDO1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
L-Tryptophan | Approved, Withdrawn | Nutra | Positive, Allosteric regulator, Enzyme, substrate | 0 | ||
Melatonin | Approved, Vet_approved | Nutra | Antagonist, Enzyme, substrate | Melatonin receptors MT inhibitor | 292 | |
Nitric Oxide | Approved | Pharma | Target | 643 | ||
Oxygen | Approved, Vet_approved | Pharma | 0 | |||
Interferon Alfa-2a, Recombinant | Approved, Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
5-Hydroxy-N-formylkynurenine |
|
|
||||
Acetyl-N-formyl-5-methoxykynurenamine |
|
52450-38-1 |
|
|||
L-Formylkynurenine |
|
|
||||
N'-Formylkynurenine |
|
1022-31-7 |
|
(5) ApexBio Compounds for IDO1 Gene
Compound | Action | Cas Number |
---|---|---|
IDO inhibitor 1 | Indoleamine-2,3-dioxygenase inhibitor | 1204669-37-3 |
INCB024360 | Potent IDO1 inhibitor | 914471-09-3 |
INCB-024360 | potent and selective inhibitor of IDO1 | 1204669-58-8 |
Indoximod (NLG-8189) | Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor Potent and selective HDAC6 inhibitor | 110117-83-4 |
NLG919 | Potent IDO pathway inhibitor | 1402836-58-1 |
Transcripts for IDO1 Gene
mRNA/cDNA for IDO1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (86) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IDO1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IDO1
- genomics-online: gRNA clones - Search results for available IDO1 gene related products
- Applied Biological Materials CRISPR for IDO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDO1
- GenScript: Design CRISPR guide RNA sequences for IDO1
miRNA Products
- Search ViGene Biosciences for IDO1
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for IDO1
- Browse OriGene Inhibitory RNA Products For IDO1
- genomics-online: shRNA clones - Search results for available IDO1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IDO1 gene
Clone Products
- Sino Biological Human cDNA Clone for IDO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IDO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IDO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available IDO1 gene related products
- orf clones - Search results for available IDO1 gene related products
- Applied Biological Materials Clones for IDO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
Expression for IDO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Intestine (Gastrointestinal Tract)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for IDO1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IDO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of IDO1 Gene:
IDO1SOURCE GeneReport for Unigene cluster for IDO1 Gene:
Hs.840mRNA Expression by UniProt/SwissProt for IDO1 Gene:
P14902-I23O1_HUMANEvidence on tissue expression from TISSUES for IDO1 Gene
- Blood(4.5)
- Lung(4.4)
- Lymph node(3.2)
- Spleen(2.9)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for IDO1
-
OriGene qPCR primer pairs for IDO1
- genomics-online: primer clones - Search results for available IDO1 gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDO1 Gene
Orthologs for IDO1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | IDO1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | IDO1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | IDO1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ido1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Ido1 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | IDO1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | IDO1 34 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BNA2 33 34 36 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR188C 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU05752 33 |
|
- Species where no ortholog for IDO1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IDO1 Gene
(1) SIMAP similar genes for IDO1 Gene using alignment to 6 proteins:
Variants for IDO1 Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000000684 | -- | 39,923,212(+) | T/C | intron_variant | |
rs1000011915 | -- | 39,926,512(+) | T/C | intron_variant | |
rs1000031494 | -- | 39,923,361(+) | G/A | intron_variant | |
rs1000144856 | -- | 39,920,314(+) | T/G | intron_variant | |
rs1000272871 | -- | 39,928,808(+) | A/G | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2658388 | CNV | deletion | 23128226 |
esv3616962 | CNV | loss | 21293372 |
nsv508505 | CNV | deletion | 20534489 |
Additional Variant Information for IDO1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDO1 Gene
Disorders for IDO1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
listeriosis |
|
|
bladder disease |
|
|
chlamydia |
|
|
trypanosomiasis |
|
|
immune suppression |
|
|
Additional Disease Information for IDO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IDO1 Gene
Publications for IDO1 Gene
- Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PMID: 16477023) Sugimoto H … Shiro Y (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
- Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PMID: 16842443) Cozzi A … Moroni F (Journal of viral hepatitis 2006) 3 22 25 58
- Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PMID: 2109605) Dai W … Gupta SL (Biochemical and biophysical research communications 1990) 2 3 4 58
- Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2. (PMID: 25394548) Lee YK … Choi EY (Experimental & molecular medicine 2014) 3 4 58
- Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
Products for IDO1 Gene
- R&D Systems Antibodies for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
- R&D Systems Proteins and Enzymes for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
- R&D Systems cDNA Clones for IDO1 ("Indoleamine 2,3-dioxygenase/IDO")
- Browse Primary Antibodies
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IDO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IDO1
- Search Origene for MassSpec and Protein Over-expression Lysates for IDO1
- Origene Custom Protein Services for IDO1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IDO1
- Browse OriGene Inhibitory RNA Products For IDO1
- OriGene qPCR primer pairs and template standards for IDO1
- OriGene qPCR primer pairs for IDO1
- OriGene CRISPR knockouts for IDO1
- OriGene ORF clones in human for IDO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IDO1
- GenScript: Next-day shipping of latest version cDNA ORF clones for IDO1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IDO1
- GenScript Custom Assay Services for IDO1
- GenScript Custom overexpressing Cell Line Services for IDO1
- GenScript: Design CRISPR guide RNA sequences for IDO1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IDO1
- Sino Biological Human cDNA Clone for IDO1
- Sino Biological Recombinant Proteins for IDO1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for IDO1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IDO1
- Novus Biologicals proteins and lysates for IDO1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for IDO1
- Abcam proteins for IDO1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IDO1
- Cloud-Clone Corp. Antibodies for IDO1
- Cloud-Clone Corp. Proteins for IDO1
- Cloud-Clone Corp. Assay Kits for IDO1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for IDO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for IDO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for IDO1
- VectorBuilder custom plasmid, inducible vectors for IDO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IDO1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 190 available IDO1 Antibodies ranked by validation data
- Compare Top IDO1 Antibodies
- Recommended
- 110 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 17 available IDO1 Elisa Kits ranked by validation data
- Compare Top IDO1 Elisa Kits
- antibodies-online: Search results for 13 available IDO1 Proteins ranked by validation data
- Compare Top IDO1 Proteins
- GeneTex IDO1 antibody for IDO1
- Search GeneTex for Proteins for IDO1
- ViGene Biosciences adenoviral particle packaged cDNA for IDO1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IDO1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IDO1 gene
- Search ViGene Biosciences for IDO1
- Santa Cruz Biotechnology (SCBT) Antibodies for IDO1
- Search Santa Cruz Biotechnology (SCBT) for IDO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IDO1
- Search for IDO1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for IDO1
- Horizon Cell Lines for IDO1
- genomics-online: cdna clones - Search results for available IDO1 gene related products
- orf clones - Search results for available IDO1 gene related products
- genomics-online: gRNA clones - Search results for available IDO1 gene related products
- genomics-online: primer clones - Search results for available IDO1 gene related products
- genomics-online: shRNA clones - Search results for available IDO1 gene related products
Sources for IDO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew