IDO1 Gene

Aliases
for IDO1 gene

Previous GC identifers: GC08P039891 GC08P038304

Summaries
for IDO1 gene

Genomic Views
for IDO1 gene

RefSeq DNA sequence:

NC_000008.10  NC_018919.1  NT_167187.1  

SwitchGear Promoter luciferase reporter plasmid: IDO1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDO1

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P039771:  view genomic region     (about GC identifiers)

Proteins
for IDO1 gene

2 PDB 3D structures from and Proteopedia for IDO1:

2D0T (3D)        2D0U (3D)    

Explore the universe of human proteins at neXtProt for IDO1: NX_P14902

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant IDO1 Protein
	R&D Systems Recombinant & Natural Proteins for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	Enzo Life Sciences proteins for IDO1
	OriGene Purified Protein: IDO1 OriGene Protein Over-expression Lysate: IDO1 OriGene Custom Protein Services for IDO1
	GenScript Custom Purified and Recombinant Proteins Services for IDO1
	Novus Biologicals IDO1 Protein Novus Biologicals IDO1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IDO1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IDO1
	R&D Systems Antibodies for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	Cell Signaling Technology (CST) Antibodies for IDO1  (INDO)
	OriGene Antibodies (see all 8): IDO1 OriGene Custom Antibody Services for IDO1
	GenScript Superior Antibodies for IDO1
	Novus Biologicals IDO1 Antibodies
	Abcam antibodies for IDO1
	Uscn Antibodies for IDO1
	ThermoFisher Antibody for IDO1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	GenScript Custom Assay Services for IDO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IDO1

Protein Domains /
Families
for IDO1 gene

ProtoNet protein and cluster: P14902

Function
for IDO1 gene

Enzyme Number (IUBMB): EC 1.13.11.52¹

miRNA Products:		OriGene 3'-UTR Clone: IDO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDO1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IDO1
		SwitchGear 3'UTR luciferase reporter plasmid: IDO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDO1 (see all 4) OriGene shRNA RFP: IDO1 OriGene siRNA: IDO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDO1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IDO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
		Sino Biological Human cDNA Clone for IDO1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IDO1
		Search LifeMap BioReagents cell lines for IDO1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 2 alleles) (MGI details for Ido1)

Pathways & Interactions
for IDO1 gene

	Super-pathway	contained gene-specific pathways
1	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
2	NAD metabolism	NAD metabolism 1.00 NAD metabolism 1.00
3	Tryptophan metabolism	Tryptophan metabolism 1.00 Tryptophan metabolism 0.47
4	Lymphocyte Signaling	Lymphocyte Signaling 1.00
5	Metabolism of amino acids and derivatives	Metabolism of amino acids and derivatives 1.00

1 EMD Millipore Pathway for IDO1

NAD metabolism

1 Cell Signaling Technology (CST) Pathway for IDO1

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for IDO1

NAD metabolism

1 BioSystems Pathway for IDO1

Tryptophan metabolism

3        Reactome Pathways for IDO1

	Tryptophan catabolism
	Metabolism
	Metabolism of amino acids and derivatives

3         Kegg Pathways  (Kegg details for IDO1)

	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis

IDO1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IDO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/24 Interacting proteins for IDO1 (P14902^{2, 3} ENSP00000253513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

Drugs & Compounds
for IDO1 gene

Transcripts
for IDO1 gene

Expression
for IDO1 gene

IDO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGATATA

Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	ES04(HES-4) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Line H9 (WA09) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Matrigel embedded cells (Derivation of cardio...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IDO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDO1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

Orthologs
for IDO1 gene

Paralogs
for IDO1 gene

Paralogs for IDO1 gene

IDO2²  

1 SIMAP similar gene for IDO1 using alignment to 6 protein entries:     I23O1_HUMAN (see all proteins):

IDO2

IDO1 for paralogs           About GeneDecksing

Genomic Variants
for IDO1 gene

10/306 NCBI SNPs in IDO1 are shown (see all 306)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs765061351,2	F,	--	38303029(+)	AGGAAC/TATTTT	1	--	us2k1		1		WA	118
rs736195081,2	C,	--	38303667(+)	GGTTGC/TGTTTC	1	--	us2k1		1		WA	2
rs1146212751,2	C,F,	--	38304063(+)	ATAAAC/TTGTGG	1	--	ut51		1		WA	118
rs753473741,2		--	38305572(+)	GTAGAC/TGAGTG	1	--	int1		1		WA	118
rs1155846571,2	C,F,	--	38305906(+)	ATGTAC/TTTATC	1	--	int1		1		WA	118
rs1136803191,2		--	38305979(+)	TCAGAT/GATTCG	1	--	int1		2		CSA WA	119
rs78181011,2	C,F,H,	--	38305980(+)	CAGATA/GTTCGA	1	--	int1		11		NS EA NA WA	686
rs1125920461,2		--	38306160(+)	GAGACC/GGAGGC	1	--	int1		1		CSA	1
rs78259611,2	C,	--	38306461(+)	gcactC/Ttggga	1	--	int1		0	--	--	--	--
rs726439041,2	C,F,	--	38306556(+)	CAAAAA/CAAAAT	1	--	int1		1		NA	120

HapMap Linkage Disequilibrium report for IDO1 (39759794 - 39785963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IDO1: --
Human Gene Mutation Database (HGMD): IDO1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDO1

DNA2.0 Custom Variant and Variant Library Synthesis for IDO1

Disorders / Diseases
for IDO1 gene

20/118 diseases for IDO1

10/73 Novoseek disease relationships for IDO1 gene (see all 73)    About this table

Publications
for IDO1 gene

PubMed articles for IDO1 gene, integrated from 9 sources (see all 650): (articles sorted by number of sources associating them with IDO1)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)^{1, 2, 3} Dai W. and Gupta S.L. (1990)
2. Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PubMed id 16842443)^{1, 7, 9} Cozzi A....Moroni F. (2006)
3. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)^{1, 2, 9} Sugimoto H.... Shiro Y. (2006)
4. Evolution of vertebrate indoleamine 2,3-dioxygenases. (PubMed id 18026683)^{1, 2} Yuasa H.J.... Suzuki T. (2007)
5. Molecular evidence that melatonin is enzymatically ox idized in a different manner than tryptophan: investigations with both indoleam ine 2,3-dioxygenase and myeloperoxidase. (PubMed id 15636586)^{6, 7} Ferry G....Boutin J.A. (2005)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12-->p11 by fluorescent in situ hybridization. (PubMed id 8404046)^{1, 3} Najfeld V....Gupta S.L. (1993)
8. Gene structure of human indoleamine 2,3-dioxygenase. (PubMed id 1449503)^{1, 2} Kadoya A.... Kido R. (1992)
9. Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. (PubMed id 2326172)^{1, 2} Tone S....Kido R. (1990)
10. IDO inhibits T-cell function through suppressing Vav1 expression and activation. (PubMed id 19597340)^{1, 9} Li R....Hao X. (2009)

External Searches for IDO1 gene

Genome Databases showing IDO1 gene

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Products
for IDO1 gene