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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IDO1 Gene

protein-coding GIFtS: 66
GCID: GC08P039771

indoleamine 2,3-dioxygenase 1

(Previous name: indoleamine-pyrrole 2,3 dioxygenase )
(Previous symbols: IDO, INDO)

Explore 118 diseases affiliated with
IDO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Indoleamine 2,3-Dioxygenase 1¹ ²		Indoleamine-Pyrrole 2,3 Dioxygenase¹
IDO¹ ² ³ ⁵		Indolamine 2,3 Dioxygenase²
INDO¹ ² ³ ⁵		Indole 2,3-Dioxygenase²
Indoleamine-Pyrrole 2,3-Dioxygenase² ³		EC 1.13.11.52³
IDO-1² ³

External Ids:	HGNC: 6059¹	Entrez Gene: 3620²	Ensembl: ENSG00000131203⁷	OMIM: 147435⁵	UniProtKB: P14902³

Export aliases for IDO1 gene to outside databases

Previous GC identifers: GC08P039891 GC08P038304

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDO1:

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in

tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including

D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in

a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology,

immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this

enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.(provided

by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen

Gene Wiki entry for IDO1 (Indoleamine 2,3-dioxygenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IDO1 gene promoter:
GR AML1a GR-beta LUN-1 NF-kappaB HNF-4alpha1 GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IDO1 promoter sequence

Search SABiosciences Chromatin IP Primers for IDO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p12-p11

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDO1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039771: view genomic region (about GC identifiers)

Start:	39,759,794 bp from pter	End:	39,785,963 bp from pter
Size:	26,170 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902 (See protein sequence)

Recommended Name: Indoleamine 2,3-dioxygenase 1

Size: 403 amino acids; 45326 Da

Cofactor: Binds 1 heme group per subunit

2 PDB 3D structures from and Proteopedia for IDO1:

2D0T (3D)

2D0U (3D)

Secondary accessions: Q540B4

Explore the universe of human proteins at neXtProt for IDO1: NX_P14902

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14902

IDO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002155.1

ENSEMBL proteins:

ENSP00000429297 ENSP00000428716 ENSP00000430505 ENSP00000429933 ENSP00000430950

ENSP00000253513

Reactome Protein details: P14902
Human Recombinant Protein Products for IDO1:

	EMD Millipore Purified and/or Recombinant IDO1 Protein
	R&D Systems Recombinant & Natural Proteins for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	Enzo Life Sciences proteins for IDO1
	OriGene Purified Protein: IDO1 OriGene Protein Over-expression Lysate: IDO1 OriGene Custom Protein Services for IDO1
	GenScript Custom Purified and Recombinant Proteins Services for IDO1
	Novus Biologicals IDO1 Protein Novus Biologicals IDO1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IDO1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0030485	smooth muscle contractile fiber	IEA	--
GO:0032421	stereocilium bundle	IEA	--

IDO1 for ontologies About GeneDecksing

IDO1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IDO1
	R&D Systems Antibodies for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	Cell Signaling Technology (CST) Antibodies for IDO1 (INDO)
	OriGene Antibodies (see all 8): IDO1 OriGene Custom Antibody Services for IDO1
	GenScript Superior Antibodies for IDO1
	Novus Biologicals IDO1 Antibodies
	Abcam antibodies for IDO1
	Uscn Antibodies for IDO1
	ThermoFisher Antibody for IDO1

Assay Products for IDO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for IDO1 (Indoleamine 2,3-dioxygenase/IDO)
	GenScript Custom Assay Services for IDO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IDO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IDO1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000898 Indolamine_dOase

Graphical View of Domain Structure for InterPro Entry P14902

ProtoNet protein and cluster: P14902

1 Blocks protein family: IPB000898 Indoleamine 2,3-dioxygenase

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Similarity: Belongs to the indoleamine 2,3-dioxygenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: I23O1_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen

Catalytic activity: D-tryptophan + O(2) = N-formyl-D-kynurenine

Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

Enzyme regulation: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by

L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan)

Biophysicochemical properties: Kinetic parameters: KM=21.23 uM for L-tryptophan; KM=4.6 mM for D-tryptophan;

Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan;

Induction: By IFNG/IFN-gamma

Enzyme Number (IUBMB): EC 1.13.11.52¹

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004833	tryptophan 2,3-dioxygenase activity	EXP	--
GO:0009055	electron carrier activity	TAS	2109605
GO:0016597	amino acid binding	--	--
GO:0019825	oxygen binding	--	--
GO:0020037	heme binding	IEA	--

IDO1 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ido1):

cellular

hematopoietic system

homeostasis/metabolism

immune system

reproductive system

IDO1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ido1^tm1Alm for IDO1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IDO1

miRNA Products:		OriGene 3'-UTR Clone: IDO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDO1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IDO1
		SwitchGear 3'UTR luciferase reporter plasmid: IDO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDO1 (see all 4) OriGene shRNA RFP: IDO1 OriGene siRNA: IDO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDO1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IDO1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IDO1
			Sirion Biotech Customized adenovirus for overexpression of IDO1 Sirion Biotech Customized adenovirus for potent knockdown of IDO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
		Sino Biological Human cDNA Clone for IDO1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IDO1
		Search LifeMap BioReagents cell lines for IDO1
		Sirion Biotech Customized stable knockdown cell line services for IDO1 Sirion Biotech Customized inducible knockdown cell line services for IDO1 Sirion Biotech Customized stable overexpressing cell line services for IDO1 Sirion Biotech Customized inducible overexpressing cell line services for IDO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

NAD metabolism

NAD metabolism

1.00

NAD metabolism

1.00

Tryptophan metabolism

Tryptophan metabolism

1.00

Tryptophan metabolism

0.47

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IDO1

NAD metabolism

1 Cell Signaling Technology (CST) Pathway for IDO1

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for IDO1

NAD metabolism

1 BioSystems Pathway for IDO1

Tryptophan metabolism

3 Reactome Pathways for IDO1

	Tryptophan catabolism
	Metabolism
	Metabolism of amino acids and derivatives

3 Kegg Pathways (Kegg details for IDO1):

	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902

Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step

1/2

IDO1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IDO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/24 Interacting proteins for IDO1 (P14902^{2, 3} ENSP00000253513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R16A	Q96I34²^,³	MINT-65182 I2D: score=6
DDX24	Q9GZR7²^,³, ENSP00000328690⁴	MINT-65410 I2D: score=5 STRING: ENSP00000328690
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
AANAT	ENSP00000250615⁴	STRING: ENSP00000250615
AFMID	ENSP00000328938⁴	STRING: ENSP00000328938

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002534	cytokine production involved in inflammatory response	IEA	--
GO:0002666	positive regulation of T cell tolerance induction	IEA	--
GO:0002678	positive regulation of chronic inflammatory response	IEA	--
GO:0002830	positive regulation of type 2 immune response	IEA	--
GO:0006569	tryptophan catabolic process	TAS	--

IDO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IDO1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IDO1

Browse Tocris compounds for IDO1

9 HMDB Compounds for IDO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	15636586
5-Hydroxy-L-tryptophan	(+-)-5-Hydroxytryptophan (see all 21)	4350-09-8	--
5-Hydroxy-N-formylkynurenine		--	--
D-Tryptophan	(+)-tryptophan (see all 19)	153-94-6	--
Formyl-5-hydroxykynurenamine	3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole (see all 7)	2208-41-5	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
L-Tryptophan	(-)-tryptophan (see all 53)	73-22-3	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--

2 DrugBank Compounds for IDO1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Tryptophan	(-)-Tryptophan (see all 14)	73-22-3	enzyme	substrate	17417651 16842443 17430109 17015752 11752352 16887964 19290871
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate	15636586

10/57 Novoseek chemical compound relationships for IDO1 gene (see all 57) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
indoleamine	99.1	465	18612775 (2), 19519465 (2), 17942160 (2), 15063631 (2) (see all 99)
kynurenine	97.2	292	10756023 (6), 8293279 (5), 19327051 (5), 10731095 (4) (see all 99)
1-methyltryptophan	95.2	71	18418598 (5), 16887964 (3), 17605849 (2), 17234791 (2) (see all 29)
1-methyl-d-tryptophan	90.2	14	15281097 (1), 17114500 (1), 18832696 (1), 17945538 (1) (see all 8)
n-formylkynurenine	88.7	14	8288893 (1), 1591013 (1), 15206718 (1), 19275153 (1) (see all 14)
3-hydroxyanthranilic acid	84.4	10	11392499 (2), 10731095 (1), 20484731 (1), 11798468 (1) (see all 8)
l-tryptophan	83.5	56	18639341 (4), 10731095 (3), 19264674 (2), 7814143 (2) (see all 37)
quinolinic acid	82.5	24	17457312 (2), 18063923 (2), 19958238 (2), 14592780 (1) (see all 20)
neopterin	81	19	19765856 (2), 15302611 (1), 17136028 (1), 7790043 (1) (see all 17)
indolamine	80.4	11	10206145 (2), 15516717 (1), 19079205 (1), 17157205 (1) (see all 10)

2 PharmGKB related drug/compound annotations for IDO1 gene About this table

Drug/compound	PharmGKB Annotation
"interferon alfa-2a, recombinant"	CA
peginterferon alfa-2b	CA

Search CenterWatch for drugs/clinical trials and news about IDO1 / I23O1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IDO1 gene:

NM_002164.5

Unigene Cluster for IDO1:

Indoleamine 2,3-dioxygenase 1

Hs.840 [show with all ESTs]

Unigene Representative Sequence: NM_002164

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000518804 ENST00000519154 ENST00000522495 ENST00000522840 ENST00000518237(uc003xnm.3)

ENST00000253513 ENST00000521636 ENST00000521480 ENST00000523779

miRNA Products:		OriGene 3'-UTR Clone: IDO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDO1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IDO1
		SwitchGear 3'UTR luciferase reporter plasmid: IDO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDO1 (see first 1) NM_002164 (human cat#: TG312147) NM_023973 (rat cat#: TF710946) NM_023973 (rat cat#: TG710946) NM_023973 (rat cat#: TR710946) OriGene shRNA RFP: IDO1 OriGene siRNA: IDO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDO1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IDO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDO1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IDO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDO1

Additional cDNA sequence:

AK313259.1 AY221100.1 BC027882.1 JF772862.1 M34455.1 X17668.1

8 DOTS entries:

DT.408798 DT.100691410 DT.100788833 DT.65287506 DT.95330370 DT.92018039 DT.92451035 DT.95216114

24/86 AceView cDNA sequences (see all 86):

X17668 CR614485 CR591703 CB217134 CR621546 CB118974 AY221100 CD742761

AI308058 NM_002164 CR613807 CR616634 CD370496 AA478279 CA432661 BE466403

AL549895 BQ007037 BC027882 CD369108 AL549011 AL545869 AU137351 CB529600

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IDO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGATATA

About this image

IDO1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IDO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IDO1

SOURCE GeneReport for Unigene cluster: Hs.840

SABiosciences Expression via Pathway-Focused PCR Arrays including IDO1:

Amino Acid Metabolism I in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IDO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for IDO1 (if available)
TreeFam Gene Tree for IDO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IDO1 gene

IDO2²

1 SIMAP similar gene for IDO1 using alignment to 6 protein entries: I23O1_HUMAN (see all proteins):

IDO2

IDO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76506135^1,2	F	--	38303029(+)	`AGGAAC/TATTTT`	1	--	us2k¹		1		WA	118
rs73619508^1,2	C	--	38303667(+)	`GGTTGC/TGTTTC`	1	--	us2k¹		1		WA	2
rs114621275^1,2	C,F	--	38304063(+)	`ATAAAC/TTGTGG`	1	--	ut5¹		1		WA	118
rs75347374^1,2		--	38305572(+)	`GTAGAC/TGAGTG`	1	--	int¹		1		WA	118
rs115584657^1,2	C,F	--	38305906(+)	`ATGTAC/TTTATC`	1	--	int¹		1		WA	118
rs113680319^1,2		--	38305979(+)	`TCAGAT/GATTCG`	1	--	int¹		2		CSA WA	119
rs7818101^1,2	C,F,H	--	38305980(+)	`CAGATA/GTTCGA`	1	--	int¹		11		NS EA NA WA	686
rs112592046^1,2		--	38306160(+)	`GAGACC/GGAGGC`	1	--	int¹		1		CSA	1
rs7825961^1,2	C	--	38306461(+)	`gcactC/Ttggga`	1	--	int¹		0	--	--	--	--
rs72643904^1,2	C,F	--	38306556(+)	`CAAAAA/CAAAAT`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for IDO1 (39759794 - 39785963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IDO1: --
Human Gene Mutation Database (HGMD): IDO1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IDO1 for disorders           About GeneDecksing

OMIM gene information: 147435    OMIM disorders: --

20/118 diseases for IDO1 (see all 118):    About MalaCards

chronic active epstein-barr virus infection eosinophilia-myalgia syndrome diffuse large b-cell lymphoma human immunodeficiency virus infectious disease

graft versus host disease b-cell lymphomas pre-eclampsia listeriosis

transient cerebral ischemia major depressive disorder inflammatory bowel disease spotted fever

primary biliary cirrhosis spontaneous abortion irritable bowel syndrome herpes simplex

monocytic leukemia acute monocytic leukemia chronic granulomatous disease hepatitis c

1 disease from the University of Copenhagen DISEASES database for IDO1:

Cancer

10/73 Novoseek disease relationships for IDO1 gene (see all 73) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder diseases	47.9	1	17537219 (1)
inflammation	42.6	34	19155537 (3), 18547472 (2), 18036645 (2), 18063923 (2) (see all 26)
tumors	42	216	14678522 (7), 19434461 (7), 2116480 (6), 18056175 (6) (see all 87)
infection chronic	39.1	5	17876564 (1), 17671174 (1), 17767193 (1), 19007906 (1) (see all 5)
autoimmune diseases	39	9	17430113 (3), 19494274 (1), 15206723 (1), 18660704 (1) (see all 7)
toxoplasmosis cerebral	37.1	1	8617321 (1)
necrosis	35.4	27	19935463 (2), 10805371 (1), 15516717 (1), 17457312 (1) (see all 22)
nuclear cataract	35.2	1	16897708 (1)
immunodeficiency	34.1	9	16139256 (1), 17626075 (1), 16902147 (1), 17430111 (1) (see all 8)
autoimmunity	33.5	7	16476191 (1), 19023117 (1), 17360980 (1), 17767193 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: IDO1 (5 documents)

Export disorders for IDO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IDO1 gene, integrated from 9 sources (see all 650):
(articles sorted by number of sources associating them with IDO1)

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world of online information

Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)^{1, 2, 3} Dai W. and Gupta S.L. (1990)
Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PubMed id 16842443)^{1, 7, 9} Cozzi A....Moroni F. (2006)
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)^{1, 2, 9} Sugimoto H.... Shiro Y. (2006)
Evolution of vertebrate indoleamine 2,3-dioxygenases. (PubMed id 18026683)^{1, 2} Yuasa H.J.... Suzuki T. (2007)
Molecular evidence that melatonin is enzymatically ox idized in a different manner than tryptophan: investigations with both indoleam ine 2,3-dioxygenase and myeloperoxidase. (PubMed id 15636586)^{6, 7} Ferry G....Boutin J.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12-->p11 by fluorescent in situ hybridization. (PubMed id 8404046)^{1, 3} Najfeld V....Gupta S.L. (1993)
Gene structure of human indoleamine 2,3-dioxygenase. (PubMed id 1449503)^{1, 2} Kadoya A.... Kido R. (1992)
Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. (PubMed id 2326172)^{1, 2} Tone S....Kido R. (1990)
IDO inhibits T-cell function through suppressing Vav1 expression and activation. (PubMed id 19597340)^{1, 9} Li R....Hao X. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3620	HGNC: 6059	AceView: INDO	Ensembl:ENSG00000131203	euGenes: HUgn3620
ECgene: IDO1	Kegg: 3620	H-InvDB: IDO1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IDO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IDO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IDO1 gene:
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GeneCards and IP:
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indoleamine 2,3-dioxygenase 1

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IDO1 Gene

indoleamine 2,3-dioxygenase 1

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