Aliases for IDO1 Gene
External Ids for IDO1 Gene
Previous HGNC Symbols for IDO1 Gene
Previous GeneCards Identifiers for IDO1 Gene
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
GeneCards Summary for IDO1 Gene
IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include toxic oil syndrome and listeriosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO2.
UniProtKB/Swiss-Prot for IDO1 Gene
Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.