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IDO1 Gene

protein-coding   GIFtS: 65
GCID: GC08P039771

Indoleamine 2,3-Dioxygenase 1

(Previous name: indoleamine-pyrrole 2,3 dioxygenase)
(Previous symbols: IDO, INDO)
  See IDO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Indoleamine 2,3-Dioxygenase 11 2     Indoleamine-Pyrrole 2,3 Dioxygenase1
IDO1 2 3 5     Indolamine 2,3 Dioxygenase2
INDO1 2 3 5     Indole 2,3-Dioxygenase2
Indoleamine-Pyrrole 2,3-Dioxygenase2 3     EC 1.13.11.523
IDO-12 3     

External Ids:    HGNC: 60591   Entrez Gene: 36202   Ensembl: ENSG000001312037   OMIM: 1474355   UniProtKB: P149023   

Export aliases for IDO1 gene to outside databases

Previous GC identifers: GC08P039891 GC08P038304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IDO1 Gene:
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting
step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates
including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to
play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense,
neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes,
and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino
acid tryptophan.(provided by RefSeq, Feb 2011)

GeneCards Summary for IDO1 Gene:
IDO1 (indoleamine 2,3-dioxygenase 1) is a protein-coding gene. Diseases associated with IDO1 include toxic oil syndrome, and listeriosis. GO annotations related to this gene include electron carrier activity and indoleamine 2,3-dioxygenase activity. An important paralog of this gene is IDO2.

UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of
oxygen

Gene Wiki entry for IDO1 (Indoleamine 2,3-dioxygenase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IDO1 gene promoter:
         GR   AML1a   GR-beta   LUN-1   NF-kappaB   HNF-4alpha1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIDO1 promoter sequence
   Search Chromatin IP Primers for IDO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p12-p11

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDO1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P039771:  view genomic region     (about GC identifiers)

Start:
39,759,794 bp from pter      End:
39,786,309 bp from pter
Size:
26,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902 (See protein sequence)
Recommended Name: Indoleamine 2,3-dioxygenase 1  
Size: 403 amino acids; 45326 Da
Cofactor: Binds 1 heme group per subunit
2 PDB 3D structures from and Proteopedia for IDO1:
2D0T (3D)        2D0U (3D)    
Secondary accessions: Q540B4

Explore the universe of human proteins at neXtProt for IDO1: NX_P14902

Explore proteomics data for IDO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IDO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002155.1  
    ENSEMBL proteins: 
     ENSP00000429297   ENSP00000428716   ENSP00000430505   ENSP00000429933   ENSP00000430950  
     ENSP00000253513  
    Reactome Protein details: P14902

    IDO1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IDO1
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    Novus Biologicals IDO1 Protein
    Novus Biologicals IDO1 Lysates
    Sino Biological Recombinant Protein for IDO1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IDO1 

    IDO1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IDO1
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000898 Indolamine_dOase

    Graphical View of Domain Structure for InterPro Entry P14902

    ProtoNet protein and cluster: P14902

    1 Blocks protein domain: IPB000898 Indoleamine 2,3-dioxygenase

    UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
    Similarity: Belongs to the indoleamine 2,3-dioxygenase family


    Find genes that share domains with IDO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I23O1_HUMAN, P14902
    Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of
    oxygen
    Catalytic activity: D-tryptophan + O(2) = N-formyl-D-kynurenine
    Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine
    Enzyme regulation: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by
    L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan)
    Biophysicochemical properties: Kinetic parameters: KM=21.23 uM for L-tryptophan; KM=4.6 mM for D-tryptophan;
    Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan;
    Induction: By IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC 1.13.11.521

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004833tryptophan 2,3-dioxygenase activity EXP--
    GO:0005515protein binding ----
    GO:0009055electron carrier activity TAS2109605
    GO:0020037heme binding IEA--
    GO:0033754indoleamine 2,3-dioxygenase activity IEA--
         
    Find genes that share ontologies with IDO1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ido1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with IDO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ido1tm1Alm for IDO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IDO1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IDO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IDO1

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    SwitchGear 3'UTR luciferase reporter plasmidIDO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IDO1

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    Clone
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    GenScript: all cDNA clones in your preferred vector: IDO1 (NM_002164)
    Sino Biological Human cDNA Clone for IDO1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDO1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030485smooth muscle contractile fiber IEA--
    GO:0032421stereocilium bundle IEA--

    Find genes that share ontologies with IDO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IDO1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    Tryptophan metabolism0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    5Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with IDO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IDO1
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for IDO1
        NAD metabolism

    2 BioSystems Pathways for IDO1
        tryptophan degradation via kynurenine
    Tryptophan metabolism


    1 Reactome Pathway for IDO1
        Tryptophan catabolism


    3 Kegg Pathways  (Kegg details for IDO1):
        Tryptophan metabolism
    Metabolic pathways
    African trypanosomiasis

    UniProtKB/Swiss-Prot: I23O1_HUMAN, P14902
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:
    step 1/2

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDO1: 

              Amino Acid Metabolism I in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IDO1 (P149022, 3 ENSP000002535134) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3MINT-65182 I2D: score=6 
    DDX24Q9GZR72, 3, ENSP000003286904MINT-65410 I2D: score=5 STRING: ENSP00000328690
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AANATENSP000002506154STRING: ENSP00000250615
    AFMIDENSP000003289384STRING: ENSP00000328938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002534cytokine production involved in inflammatory response IEA--
    GO:0002666positive regulation of T cell tolerance induction IEA--
    GO:0002678positive regulation of chronic inflammatory response IEA--
    GO:0002830positive regulation of type 2 immune response IEA--
    GO:0006569tryptophan catabolic process TAS--

    Find genes that share ontologies with IDO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IDO1
      Browse compounds at ApexBio 

    Browse Tocris compounds for IDO1 (I23O1)

    9 HMDB Compounds for IDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-415636586
    5-Hydroxy-L-tryptophan(+-)-5-Hydroxytryptophan (see all 21)4350-09-8--
    5-Hydroxy-N-formylkynurenine ----
    D-Tryptophan(+)-tryptophan (see all 19)153-94-6--
    Formyl-5-hydroxykynurenamine3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole (see all 7)2208-41-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    OxygenOxygen (see all 5)7782-44-7--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    2 DrugBank Compounds for IDO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3enzymesubstrate17417651 16842443 17430109 17015752 11752352 16887964 19290871
    MelatoninMEL (see all 4)73-31-4enzymesubstrate15636586

    Selected Novoseek inferred chemical compound relationships for IDO1 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indoleamine 99.1 465 18612775 (2), 19519465 (2), 17942160 (2), 15063631 (2), 19155537 (2), 18055547 (2), 15961516 (2), 17483297 (2), 7897249 (2), 12014674 (2), 19828695 (2), 18008147 (2), 15624557 (2), 18847306 (2), 15572592 (2), 20128646 (2), 14719046 (2), 17700060 (2), 16686756 (2), 16394644 (2), 8288893 (1), 7537250 (1), 7615820 (1), 7665918 (1), 8765749 (1), 10731095 (1), 10805371 (1), 11465083 (1), 11180976 (1), 12186837 (1), 11934353 (1), 12605704 (1), 15206720 (1), 15086404 (1), 15302611 (1), 15967116 (1), 16113824 (1), 19738905 (1), 16511306 (1), 16421220 (1), 16513157 (1), 16574111 (1), 16797727 (1), 16741252 (1), 17303977 (1), 17136028 (1), 15206741 (1), 15206713 (1), 15132006 (1), 12766158 (1), 12711393 (1), 11553555 (1), 10786059 (1), 9731757 (1), 8926087 (1), 18824197 (1), 19421183 (1), 19308046 (1), 19275153 (1), 19162548 (1), 19143868 (1), 17924666 (1), 17521318 (1), 17195079 (1), 10510970 (1), 10500295 (1), 10721096 (1), 10721095 (1), 9879957 (1), 7490512 (1), 8070686 (1), 7901291 (1), 8406467 (1), 10843733 (1), 2166783 (1), 19921535 (1), 20379874 (1), 7523670 (1), 20137504 (1), 19783182 (1), 19665763 (1), 19740324 (1), 17349013 (1), 17191041 (1), 17294609 (1), 16997853 (1), 15512788 (1), 15281097 (1), 15102781 (1), 14748880 (1), 8817290 (1), 7790043 (1), 1591013 (1), 1937018 (1), 20178337 (1), 19941414 (1), 19802733 (1), 19693771 (1), 17430112 (1) (see top 4)
    kynurenine 97.2 292 10756023 (6), 8293279 (5), 19327051 (5), 10731095 (4), 19155537 (4), 19487045 (4), 7490512 (3), 15950064 (3), 17936210 (3), 19958238 (3), 10939284 (3), 15494706 (3), 18676626 (3), 16513157 (2), 7617307 (2), 19783182 (2), 15853924 (2), 8817290 (2), 9466588 (2), 19540675 (2), 17192467 (2), 12963490 (2), 19363598 (2), 16842443 (2), 16261283 (2), 15001472 (2), 10821443 (2), 16907915 (2), 10834318 (2), 19918244 (2), 18397228 (2), 1722946 (2), 18712654 (2), 18465467 (2), 18063923 (2), 17594069 (2), 19597571 (2), 18639339 (2), 7615820 (1), 11465083 (1), 17303977 (1), 17320464 (1), 17870068 (1), 18516521 (1), 19021508 (1), 12766158 (1), 8926087 (1), 1532618 (1), 1647247 (1), 19693771 (1), 19519465 (1), 18612775 (1), 19264674 (1), 18639341 (1), 17711489 (1), 16236119 (1), 16075385 (1), 15380529 (1), 14719046 (1), 12871129 (1), 11571701 (1), 11559441 (1), 17896864 (1), 17103092 (1), 16687019 (1), 17062375 (1), 16417228 (1), 16490253 (1), 15995595 (1), 12966593 (1), 1909303 (1), 19491279 (1), 19853722 (1), 19815714 (1), 19434461 (1), 18823288 (1), 19228097 (1), 18370410 (1), 17945348 (1), 17945538 (1), 17999277 (1), 18094439 (1), 17626075 (1), 17158233 (1), 16139256 (1), 16319139 (1), 16118322 (1), 15206722 (1), 12479977 (1), 11912287 (1), 2166783 (1), 8417138 (1), 20037301 (1), 20047157 (1), 17355802 (1), 19106591 (1), 18950381 (1), 18832696 (1), 7523670 (1) (see top 4)
    1-methyltryptophan 95.2 71 18418598 (5), 16887964 (3), 17605849 (2), 17234791 (2), 17999277 (2), 17870068 (1), 19494274 (1), 19740324 (1), 19665763 (1), 14678522 (1), 17911610 (1), 16420054 (1), 15780178 (1), 19740378 (1), 19307751 (1), 19461669 (1), 18712654 (1), 17430113 (1), 17164341 (1), 18698365 (1), 10725715 (1), 18064486 (1), 18676626 (1), 15206723 (1), 16360837 (1), 17158233 (1), 17360980 (1), 16236119 (1), 16899371 (1) (see top 4)
    1-methyl-d-tryptophan 90.2 14 15281097 (1), 17114500 (1), 18832696 (1), 17945538 (1), 19010841 (1), 12950637 (1), 15961516 (1), 17609291 (1) (see top 4)
    n-formylkynurenine 88.7 14 8288893 (1), 1591013 (1), 15206718 (1), 19275153 (1), 12479977 (1), 17644189 (1), 10821443 (1), 18094439 (1), 18370410 (1), 17609291 (1), 8132317 (1), 15206745 (1), 17430117 (1), 20025603 (1) (see top 4)
    3-hydroxyanthranilic acid 84.4 10 11392499 (2), 10731095 (1), 20484731 (1), 11798468 (1), 18289708 (1), 16490253 (1), 15950064 (1), 17303977 (1) (see top 4)
    l-tryptophan 83.5 56 18639341 (4), 10731095 (3), 19264674 (2), 7814143 (2), 10510970 (2), 10721097 (2), 8288893 (1), 16113824 (1), 11392499 (1), 17535808 (1), 8417138 (1), 10721098 (1), 7897249 (1), 20000778 (1), 18501338 (1), 16834326 (1), 18370410 (1), 17999277 (1), 16365430 (1), 8293279 (1), 18671950 (1), 16359238 (1), 15374002 (1), 13678429 (1), 10206145 (1), 9916720 (1), 19918244 (1), 18226121 (1), 15919929 (1), 15826869 (1), 18712870 (1), 16360837 (1), 19275153 (1), 1532618 (1), 16797727 (1), 17320464 (1), 19021508 (1) (see top 4)
    quinolinic acid 82.5 24 17457312 (2), 18063923 (2), 19958238 (2), 14592780 (1), 18516521 (1), 11523587 (1), 20047157 (1), 11798468 (1), 9657528 (1), 19918244 (1), 15182307 (1), 12414962 (1), 10834318 (1), 17594069 (1), 15961516 (1), 17661345 (1), 8417138 (1), 19155537 (1), 7617307 (1), 16459240 (1) (see top 4)
    neopterin 81 19 19765856 (2), 15302611 (1), 17136028 (1), 7790043 (1), 15206718 (1), 2166783 (1), 12479977 (1), 16139256 (1), 19040353 (1), 19167991 (1), 1717569 (1), 17113915 (1), 1909303 (1), 15158610 (1), 16687019 (1), 15896467 (1), 17430111 (1) (see top 4)
    indolamine 80.4 11 10206145 (2), 15516717 (1), 19079205 (1), 17157205 (1), 15206723 (1), 15579280 (1), 1917395 (1), 7542758 (1), 8617321 (1), 10756023 (1) (see top 4)

    2 PharmGKB related drug/compound annotations for IDO1 gene    About this table
    Drug/compound PharmGKB Annotation
    interferon alfa-2a, recombinantCA  
    peginterferon alfa-2bCA  



    Find genes that share compounds with IDO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IDO1 gene: 
    NM_002164.5  

    Unigene Cluster for IDO1:

    Indoleamine 2,3-dioxygenase 1
    Hs.840  [show with all ESTs]
    Unigene Representative Sequence: NM_002164
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518804 ENST00000519154 ENST00000522495 ENST00000522840 ENST00000518237(uc003xnm.3)
    ENST00000253513 ENST00000521636 ENST00000521480 ENST00000523779
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    Additional mRNA sequence: 

    AK313259.1 AY221100.1 BC027882.1 JF772862.1 M34455.1 X17668.1 

    8 DOTS entries:

    DT.408798  DT.100691410  DT.100788833  DT.65287506  DT.95330370  DT.92018039  DT.92451035  DT.95216114 

    Selected AceView cDNA sequences (see all 86):

    X17668 AL549895 CR613807 BE466403 CB118974 CD369108 CR591703 AU137351 
    CA432661 AA478279 BX113985 CB529600 CR621546 CD742761 AL549011 AA478338 
    AY221100 AI308058 BC027882 NM_002164 CB217134 AL545869 CR616634 AL554455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGATATA
    IDO1 Expression
    About this image


    IDO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Striatum
     
     Placenta (Extraembryonic Tissues)
    IDO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IDO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.840
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDO1: 
              Amino Acid Metabolism I in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IDO1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ido11 , 5 indoleamine 2,3-dioxygenase 11, 5 72.24(n)1
    62.53(a)1
      8 (12.76 cM)5
    159301  NM_008324.11  NP_032350.11 
     245841365 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA2(YJR078W)4
    BNA21
    Putative tryptophan 2,3-dioxygenase or indoleamine more4
    BNA21
    45(n)1
    35.29(a)1
      10(578860-580221)4
    8535411, 4  NP_012612.31  NP_012612.14 


    ENSEMBL Gene Tree for IDO1 (if available)
    TreeFam Gene Tree for IDO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IDO1 gene
    IDO22  
    1 SIMAP similar gene for IDO1 using alignment to 6 protein entries:     I23O1_HUMAN (see all proteins):
    IDO2

    Find genes that share paralogs with IDO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IDO1 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726439041,2
    C,F--39773846(+) CAAAAA/CAAAAT 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1129234211,2
    F--39773860(+) CCAGCA/GTGTTG 1 -- int12Minor allele frequency- G:0.04CSA WA 119
    rs113375171,2
    C,F--39780923(+) AAAAAA/-AAAAA 1 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs671169791,2
    C--39780923(+) GTCTC-/AAAAAAA 1 -- int10--------
    rs788791671,2
    C--39781630(+) ATCTG-/CCCTAC 1 -- int10--------
    rs748931141,2
    F--39784436(+) TAACTC/TCCACT 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1148016331,2
    F--39840440(+) AGAGCA/CAAACG 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs38086061,2
    C,F,A,H--39840481(-) CAGGTC/TGTTAT 1 -- us2k124Minor allele frequency- T:0.41NA NS EA WA CSA 1667
    rs1442505061,2
    C--39840591(+) TGTAG-/GTAGTATG 1 -- cds10--------
    rs1444668831,2
    --39840611(+) AATCAA/TGGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IDO1 (39759794 - 39786309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IDO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658388CNV Deletion23128226
    nsv508505CNV Loss20534489

    Human Gene Mutation Database (HGMD): IDO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IDO1
    DNA2.0 Custom Variant and Variant Library Synthesis for IDO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147435    OMIM disorders: --

    10 diseases for IDO1:    
    About MalaCards
    toxic oil syndrome    listeriosis    trachoma    mediterranean spotted fever
    bladder disease    eosinophilia-myalgia syndrome    toxoplasmosis    typhus
    scrub typhus    malaria

    2 diseases from the University of Copenhagen DISEASES database for IDO1:
    eosinophilia-myalgia syndrome     Cancer

    Find genes that share disorders with IDO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IDO1 gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder diseases 47.9 1 17537219 (1)
    inflammation 42.6 34 19155537 (3), 18547472 (2), 18036645 (2), 18063923 (2) (see all 26)
    tumors 42 216 14678522 (7), 19434461 (7), 2116480 (6), 18056175 (6) (see all 87)
    infection chronic 39.1 5 17876564 (1), 17671174 (1), 17767193 (1), 19007906 (1) (see all 5)
    autoimmune diseases 39 9 17430113 (3), 19494274 (1), 15206723 (1), 18660704 (1) (see all 7)
    toxoplasmosis cerebral 37.1 1 8617321 (1)
    necrosis 35.4 27 19935463 (2), 10805371 (1), 15516717 (1), 17457312 (1) (see all 22)
    nuclear cataract 35.2 1 16897708 (1)
    immunodeficiency 34.1 9 16139256 (1), 17626075 (1), 16902147 (1), 17430111 (1) (see all 8)
    autoimmunity 33.5 7 16476191 (1), 19023117 (1), 17360980 (1), 17767193 (1) (see all 5)

    Genetic Association Database (GAD): IDO1
    Human Genome Epidemiology (HuGE) Navigator: IDO1 (5 documents)

    Export disorders for IDO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IDO1 gene, integrated from 10 sources (see all 674):
    (articles sorted by number of sources associating them with IDO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)1, 2, 3 Dai W. and Gupta S.L. (Biochem. Biophys. Res. Commun. 1990)
    2. Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PubMed id 16842443)1, 7, 9 Cozzi A....Moroni F. (J. Viral Hepat. 2006)
    3. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)1, 2, 9 Sugimoto H.... Shiro Y. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    5. Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (PubMed id 20192952)1, 4 Nishizawa H....Udagawa Y. (Am. J. Reprod. Immunol. 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    8. Evolution of vertebrate indoleamine 2,3-dioxygenases. (PubMed id 18026683)1, 2 Yuasa H.J.... Suzuki T. (J. Mol. Evol. 2007)
    9. Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. (PubMed id 15636586)6, 7 Ferry G....Boutin J.A. (Biochem. J. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3620 HGNC: 6059 AceView: INDO Ensembl:ENSG00000131203 euGenes: HUgn3620
    ECgene: IDO1 Kegg: 3620 H-InvDB: IDO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IDO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IDO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IDO1 gene:
    Search GeneIP for patents involving IDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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