IDNK Gene
protein-coding GIFtS: 39
GCID: GC09P086238
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idnK, gluconokinase homolog (E. coli)(Previous name: chromosome 9 open reading frame 103 )
(Previous symbol: C9orf103)
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Aliases
for IDNK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IdnK, Gluconokinase Homolog (E. Coli)1 2 | | Glucokinase-Like Protein2 | | C9orf1031 2 3 | | Gluconokinase-Like Protein2 | | BA522I20.21 | | Probable Gluconokinase2 | | Gluconate Kinase2 3 | | EC 2.7.1.123 | | Chromosome 9 Open Reading Frame 1031 | | |
Export aliases for IDNK gene to outside databases |
Summaries
for IDNK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IDNK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IDNK
Other transcription factors
Search SABiosciences Chromatin IP Primers for IDNK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDNK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.32 Ensembl cytogenetic band: 9q21.32 HGNC cytogenetic band: 9q21.32IDNK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P086238: view genomic region
(about GC identifiers)
Start:
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86,237,964 bp from pter |
End:
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86,259,045 bp from pter |
Size:
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21,082 bases |
Orientation:
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plus strand |
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Proteins
for IDNK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GNTK_HUMAN, Q5T6J7 (See
protein sequence)Recommended Name: Probable gluconokinase Size: 187 amino acids; 20578 Da
Secondary accessions: A5PLN6 Q5T6J6Alternative splicing: 3 isoforms: Q5T6J7-1 Q5T6J7-2 Q5T6J7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IDNK: NX_Q5T6J7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T6J7
IDNK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001001551.2 NP_001243844.1
ENSEMBL proteins: ENSP00000434673 ENSP00000436381 ENSP00000385324 ENSP00000365599 ENSP00000365601 ENSP00000403290 ENSP00000277124
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
IDNK for ontologies About GeneDecksing
IDNK Antibody Products:
Assay Products for IDNK: |
Protein
Domains /
Families
for IDNK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IDNK for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T6J7ProtoNet protein and cluster: Q5T6J7 UniProtKB/Swiss-Prot: GNTK_HUMAN, Q5T6J7Similarity: Belongs to the gluconokinase GntK/GntV family |
Function
for IDNK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GNTK_HUMAN, Q5T6J7Catalytic activity: ATP + D-gluconate = ADP + 6-phospho-D-gluconateEnzyme Number (IUBMB): EC 2.7.1.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for IDNK | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDNK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDNK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDNK |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IDNK for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Idnktm1Lex for IDNK
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Idnk):
IDNK for phenotypes About GeneDecksing
|
Pathways & Interactions
for IDNK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: GNTK_HUMAN, Q5T6J7Pathway: Carbohydrate acid metabolism; D-gluconate degradationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IDNK
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0046177 | D-gluconate catabolic process |
IEA | -- |
IDNK for ontologies About GeneDecksing
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Drugs & Compounds
for IDNK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IDNK
Search CenterWatch for drugs/clinical trials and news about IDNK / GNTK
|
Transcripts
for IDNK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IDNK gene (3 alternative transcripts): NM_001190727.1 NM_001001551.3 NM_001256915.1 Unigene Cluster for IDNK: IdnK, gluconokinase homolog (E. coli) Hs.530261 [show with all ESTs]Unigene Representative Sequence: NR_0464227 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533522(uc004amt.2 uc004amu.2) ENST00000530832 ENST00000405990(uc010mpv.2)
ENST00000376417 ENST00000376419 ENST00000454393 ENST00000277124
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for IDNK | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDNK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDNK |
Additional cDNA sequence: AF086281.1 AY615889.1 BC036421.1 BC045782.1 BC142991.1 NR_046421.1 NR_046422.1 4 DOTS entries: DT.111382 DT.101979487 DT.100016072 DT.100019066 24/52 AceView cDNA sequences (see all 52): AI302761 AA745496 BU783477 AA701937 AA825764 AA773315 AF086281 AW135438 BM984942 W69675 AW119128 CB069898 AI640497 AI630992 CA844116 W69674 BI826543 AA935859 NM_001001551 AA679299 CB121229 AI076392 BC045782 AI185795
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for IDNK About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for IDNK
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Expression
for IDNK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IDNK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGTATTTG
About this image
See IDNK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IDNK
SOURCE GeneReport for Unigene cluster: Hs.530261
SABiosciences Custom PCR Arrays for IDNK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDNK
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IDNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDNK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDNK |
Orthologs
for IDNK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for IDNK gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for IDNK (if available)
TreeFam Gene Tree for IDNK (if available) |
Paralogs
for IDNK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IDNK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IDNK (86237964 - 86259045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IDNK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDNK |
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Disorders
/ Diseases
for IDNK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IDNK for disorders About GeneDecksing
OMIM gene information: 611343
OMIM disorders: --
5  diseases for IDNK: About MalaCardsintrahepatic cholangiocarcinoma acute myeloid leukemia myeloid leukemia cholangiocarcinoma
leukemia
Export disorders for IDNK gene to outside databases
|
Publications
for IDNK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IDNK gene integrated from 9 sources:
(articles sorted by number of sources associating them with IDNK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PubMed id 16015647)2 Sweetser D.A.... Daly S.B. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for IDNK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IDNK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IDNK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IDNK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IDNK | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IDNK gene:
Search GeneIP for patents involving IDNK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IDNK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IDNK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDNK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDNK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IDNK | | OriGene 3'-UTR Clone for IDNK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDNK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IDNK | | OriGene Custom Protein Services for IDNK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IDNK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDNK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDNK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDNK |
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 |  |  |  | |
| | | | Search Tocris compounds for IDNK |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDNK |
|  |  |  | | | | Search ThermoFisher Antibodies for IDNK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDNK |
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