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Aliases for IDNK Gene

Aliases for IDNK Gene

  • IDNK, Gluconokinase 2 3 5
  • Gluconate Kinase 3 4
  • C9orf103 3 4
  • IdnK, Gluconokinase Homolog (E. Coli) 2
  • Chromosome 9 Open Reading Frame 103 2
  • IdnK, Gluconokinase Homolog 3
  • Gluconokinase-Like Protein 3
  • Glucokinase-Like Protein 3
  • Probable Gluconokinase 3
  • EC 2.7.1.12 4
  • BA522I20.2 3
  • HGntK 3

External Ids for IDNK Gene

Previous HGNC Symbols for IDNK Gene

  • C9orf103

Previous GeneCards Identifiers for IDNK Gene

  • GC09P086238

Summaries for IDNK Gene

GeneCards Summary for IDNK Gene

IDNK (IDNK, Gluconokinase) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include kinase activity and gluconokinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDNK Gene

Genomics for IDNK Gene

Regulatory Elements for IDNK Gene

Enhancers for IDNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F083620 1.6 FANTOM5 Ensembl ENCODE 12.2 +0.4 370 5.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 ZNF143 KLF7 LOC105376114 IDNK KIF27 UBQLN1 GKAP1 GC09M083666
GH09F083628 1.2 Ensembl ENCODE 12.4 +7.3 7252 3.3 MLX ARID4B DMAP1 YBX1 ZNF48 YY1 ZNF143 ZNF207 FOS SP5 LOC105376114 IDNK GC09M083666
GH09F083598 1 Ensembl ENCODE 11.7 -24.3 -24286 1.3 GATAD2A HLF FOXA3 CEBPB CEBPG THRB PPARG ZNF644 EP300 RARA IDNK GC09M083604 RNU4-15P GC09M083572
GH09F083705 1.1 ENCODE 10.5 +84.4 84434 3.9 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 LOC105376114 IDNK GC09M083666
GH09F083698 1 Ensembl ENCODE 11.1 +77.2 77210 4.5 ZNF146 ZFP64 ZNF140 MAX ZNF101 ZNF138 ZNF433 ZNF202 ZBTB11 OVOL3 LOC105376114 IDNK UBQLN1 GC09M083666
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IDNK on UCSC Golden Path with GeneCards custom track

Promoters for IDNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001307004 251 1801 HDGF ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 KLF7 ZNF202 SP3

Genomic Location for IDNK Gene

Chromosome:
9
Start:
83,623,049 bp from pter
End:
83,644,130 bp from pter
Size:
21,082 bases
Orientation:
Plus strand

Genomic View for IDNK Gene

Genes around IDNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDNK Gene

Proteins for IDNK Gene

  • Protein details for IDNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6J7-GNTK_HUMAN
    Recommended name:
    Probable gluconokinase
    Protein Accession:
    Q5T6J7
    Secondary Accessions:
    • A5PLN6
    • Q5T6J6

    Protein attributes for IDNK Gene

    Size:
    187 amino acids
    Molecular mass:
    20578 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IDNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDNK Gene

Post-translational modifications for IDNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IDNK Gene

Domains & Families for IDNK Gene

Protein Domains for IDNK Gene

Suggested Antigen Peptide Sequences for IDNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T6J7

UniProtKB/Swiss-Prot:

GNTK_HUMAN :
  • Belongs to the gluconokinase GntK/GntV family.
Family:
  • Belongs to the gluconokinase GntK/GntV family.
genes like me logo Genes that share domains with IDNK: view

No data available for Gene Families for IDNK Gene

Function for IDNK Gene

Molecular function for IDNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Enzyme Numbers (IUBMB) for IDNK Gene

Gene Ontology (GO) - Molecular Function for IDNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046316 gluconokinase activity IBA --
genes like me logo Genes that share ontologies with IDNK: view
genes like me logo Genes that share phenotypes with IDNK: view

Animal Models for IDNK Gene

MGI Knock Outs for IDNK:

Animal Model Products

miRNA for IDNK Gene

miRTarBase miRNAs that target IDNK

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IDNK Gene

Localization for IDNK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDNK gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IDNK Gene

Pathways & Interactions for IDNK Gene

genes like me logo Genes that share pathways with IDNK: view

Pathways by source for IDNK Gene

UniProtKB/Swiss-Prot Q5T6J7-GNTK_HUMAN

  • Pathway: Carbohydrate acid metabolism; D-gluconate degradation.

Interacting Proteins for IDNK Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365601%0d%0a9606.ENSP00000303057%0d%0a9606.ENSP00000300026%0d%0a
Selected Interacting proteins: Q5T6J7-GNTK_HUMAN ENSP00000365601 for IDNK Gene via IID STRING

Gene Ontology (GO) - Biological Process for IDNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
GO:0044262 cellular carbohydrate metabolic process IBA --
GO:0046177 D-gluconate catabolic process IEA --
genes like me logo Genes that share ontologies with IDNK: view

No data available for SIGNOR curated interactions for IDNK Gene

Drugs & Compounds for IDNK Gene

(3) Drugs for IDNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gluconic acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
6-Phosphogluconic acid Experimental Pharma 0

(1) Additional Compounds for IDNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with IDNK: view

Transcripts for IDNK Gene

Unigene Clusters for IDNK Gene

IdnK, gluconokinase homolog (E. coli):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDNK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for IDNK Gene

GeneLoc Exon Structure for
IDNK
ECgene alternative splicing isoforms for
IDNK

Expression for IDNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IDNK Gene

This gene is overexpressed in Liver (18.7) and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDNK Gene



NURSA nuclear receptor signaling pathways regulating expression of IDNK Gene:

IDNK

SOURCE GeneReport for Unigene cluster for IDNK Gene:

Hs.530261
genes like me logo Genes that share expression patterns with IDNK: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IDNK Gene

Orthologs for IDNK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDNK 34 35
  • 97.3 (n)
dog
(Canis familiaris)
Mammalia IDNK 34 35
  • 88.29 (n)
cow
(Bos Taurus)
Mammalia LOC100297815 34
  • 87.03 (n)
IDNK 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idnk 34 16 35
  • 80.07 (n)
rat
(Rattus norvegicus)
Mammalia Idnk 34
  • 78.92 (n)
oppossum
(Monodelphis domestica)
Mammalia IDNK 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDNK 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF103 34
  • 66.28 (n)
IDNK 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDNK 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idnk 34
  • 61.79 (n)
worm
(Caenorhabditis elegans)
Secernentea F26D11.1 34 35
  • 49.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDR248C 34
  • 50.47 (n)
-- 35
  • 30 (a)
OneToOne
-- 37
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR164C 34
  • 49.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12078g 34
  • 46.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G16790 34
  • 56.09 (n)
rice
(Oryza sativa)
Liliopsida Os06g0114650 34
  • 49.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02702 34
  • 48.95 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4G9.12 34
  • 45.56 (n)
Species where no ortholog for IDNK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IDNK Gene

ENSEMBL:
Gene Tree for IDNK (if available)
TreeFam:
Gene Tree for IDNK (if available)

Paralogs for IDNK Gene

No data available for Paralogs for IDNK Gene

Variants for IDNK Gene

Sequence variations from dbSNP and Humsavar for IDNK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10118651 -- 83,622,283(+) GGAAG(C/T)GGAGC upstream-variant-2KB
rs10512136 -- 83,637,237(+) TGGAA(A/G)TAAAG intron-variant
rs1052690 -- 83,643,770(+) CCTAA(A/C)AATGA nc-transcript-variant, downstream-variant-500B, reference, missense
rs1056086 -- 83,627,687(+) CATGT(A/C)CTTTA intron-variant
rs10579059 -- 83,627,135(+) TTAAA(-/T)AAAAA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IDNK Gene

Variant ID Type Subtype PubMed ID
nsv516587 CNV loss 19592680

Variation tolerance for IDNK Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDNK Gene

Disorders for IDNK Gene

Relevant External Links for IDNK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDNK

No disorders were found for IDNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDNK Gene

Publications for IDNK Gene

  1. Kinetic analysis of gluconate phosphorylation by human gluconokinase using isothermal titration calorimetry. (PMID: 26505675) Rohatgi N. … Rolfsson A.9. (FEBS Lett. 2015) 2 3 64
  2. Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysis. (PMID: 24896608) Rohatgi N. … Rolfsson A.9. (PLoS ONE 2014) 2 3 64
  3. Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity. (PMID: 23067238) Rolfsson A.9. … Thiele I. (Biochem. J. 2013) 2 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for IDNK Gene

Sources for IDNK Gene

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