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Aliases for IDI2 Gene

Aliases for IDI2 Gene

  • Isopentenyl-Diphosphate Delta Isomerase 2 2 3
  • IPPI2 3 4 6
  • Isopentenyl Pyrophosphate Isomerase 2 3 4
  • IPP Isomerase 2 3 4
  • Diphosphate Dimethylallyl Diphosphate Isomerase 2 3
  • Isopentenyl-Diphosphate Delta-Isomerase 2 3
  • EC 5.3.3.2 4

External Ids for IDI2 Gene

Summaries for IDI2 Gene

GeneCards Summary for IDI2 Gene

IDI2 (Isopentenyl-Diphosphate Delta Isomerase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include hydrolase activity and isopentenyl-diphosphate delta-isomerase activity. An important paralog of this gene is IDI1.

UniProtKB/Swiss-Prot for IDI2 Gene

  • Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDI2 Gene

Genomics for IDI2 Gene

Genomic Location for IDI2 Gene

Start:
1,018,907 bp from pter
End:
1,025,859 bp from pter
Size:
6,953 bases
Orientation:
Minus strand

Genomic View for IDI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDI2 Gene

Regulatory Elements for IDI2 Gene

Proteins for IDI2 Gene

  • Protein details for IDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS1-IDI2_HUMAN
    Recommended name:
    Isopentenyl-diphosphate delta-isomerase 2
    Protein Accession:
    Q9BXS1
    Secondary Accessions:

    Protein attributes for IDI2 Gene

    Size:
    227 amino acids
    Molecular mass:
    26753 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IDI2 Gene

neXtProt entry for IDI2 Gene

Proteomics data for IDI2 Gene at MOPED

Post-translational modifications for IDI2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys47

Other Protein References for IDI2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IDI2 Gene

Domains for IDI2 Gene

UniProtKB/Swiss-Prot:

IDI2_HUMAN
Domain:
  • Contains 1 nudix hydrolase domain.:
    • Q9BXS1
Family:
  • Belongs to the IPP isomerase type 1 family.:
    • Q9BXS1
genes like me logo Genes that share domains with IDI2: view

Function for IDI2 Gene

Molecular function for IDI2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Isopentenyl diphosphate = dimethylallyl diphosphate
UniProtKB/Swiss-Prot Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Enzyme Numbers (IUBMB) for IDI2 Gene

Gene Ontology (GO) - Molecular Function for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004452 isopentenyl-diphosphate delta-isomerase activity IDA 17202134
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDI2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IDI2 Gene

Localization for IDI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDI2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDI2 Gene COMPARTMENTS Subcellular localization image for IDI2 gene
Compartment Confidence
peroxisome 5
cytosol 4
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 17202134
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IDI2: view

Pathways for IDI2 Gene

genes like me logo Genes that share pathways with IDI2: view

UniProtKB/Swiss-Prot Q9BXS1-IDI2_HUMAN

  • Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1

Gene Ontology (GO) - Biological Process for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008299 isoprenoid biosynthetic process IDA 17202134
GO:0044281 small molecule metabolic process TAS --
GO:0046490 isopentenyl diphosphate metabolic process IDA 17202134
GO:0050992 dimethylallyl diphosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with IDI2: view

Compounds for IDI2 Gene

(3) HMDB Compounds for IDI2 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylallylpyrophosphate
  • 1,1-Dimethyl-4-phenylpiperazinium iodide
358-72-5
Isopentenyl pyrophosphate
  • 3-Methyl-3-butenyl pyrophosphate
358-71-4
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with IDI2: view

Transcripts for IDI2 Gene

mRNA/cDNA for IDI2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IDI2 Gene

Isopentenyl-diphosphate delta isomerase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IDI2 Gene

No ASD Table

Relevant External Links for IDI2 Gene

GeneLoc Exon Structure for
IDI2
ECgene alternative splicing isoforms for
IDI2

Expression for IDI2 Gene

mRNA expression in normal human tissues for IDI2 Gene

mRNA differential expression in normal tissues according to GTEx for IDI2 Gene

This gene is overexpressed in Muscle - Skeletal (51.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IDI2 Gene

SOURCE GeneReport for Unigene cluster for IDI2 Gene Hs.9270

mRNA Expression by UniProt/SwissProt for IDI2 Gene

Q9BXS1-IDI2_HUMAN
Tissue specificity: Detected in skeletal muscle.
genes like me logo Genes that share expressions with IDI2: view

Orthologs for IDI2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDI2 36
  • 99.27 (n)
  • 98.24 (a)
IDI2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9745 37
  • 66 (a)
OneToMany
Idi2 16
Idi2 37
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IDI2 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564347 36
  • 75.18 (n)
  • 71.81 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii idi1 37
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5919 37
  • 35 (a)
OneToMany
CG5919 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea idi-1 37
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDI1 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9971 37
  • 42 (a)
OneToMany
Species with no ortholog for IDI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IDI2 Gene

ENSEMBL:
Gene Tree for IDI2 (if available)
TreeFam:
Gene Tree for IDI2 (if available)

Paralogs for IDI2 Gene

Paralogs for IDI2 Gene

Selected SIMAP similar genes for IDI2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IDI2: view

Variants for IDI2 Gene

Sequence variations from dbSNP and Humsavar for IDI2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1044261 -- 1,019,770(+) CTCCC(C/T)AAATT stop-gained, reference
rs1051451 -- 1,019,007(+) ATACG(C/G)ATCTT utr-variant-3-prime
rs2170142 -- 1,019,000(+) TGAGA(C/G/T)CATAC utr-variant-3-prime
rs2279257 -- 1,020,019(+) TAAAC(C/T)GGCTT intron-variant
rs3214941 -- 1,019,264(+) CTTAT(-/A)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IDI2 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
dgv589n71 CNV Loss 21882294

Relevant External Links for IDI2 Gene

HapMap Linkage Disequilibrium report
IDI2

Disorders for IDI2 Gene

Relevant External Links for IDI2

Genetic Association Database (GAD)
IDI2
Human Genome Epidemiology (HuGE) Navigator
IDI2
genes like me logo Genes that share disorders with IDI2: view

No data available for UniProtKB/Swiss-Prot for IDI2 Gene

Publications for IDI2 Gene

  1. IDI2, a second isopentenyl diphosphate isomerase in mammals. (PMID: 17202134) Clizbe D.B. … Krisans S.K. (J. Biol. Chem. 2007) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for IDI2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IDI2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IDI2
    • Block miRNA regulation of IDI2 using miScript Target Protectors
    • Addgene plasmids for IDI2

    Sources for IDI2 Gene

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