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Aliases for IDI2 Gene

Aliases for IDI2 Gene

  • Isopentenyl-Diphosphate Delta Isomerase 2 2 3 5
  • Isopentenyl Pyrophosphate Isomerase 2 3 4
  • IPP Isomerase 2 3 4
  • IPPI2 3 4
  • Diphosphate Dimethylallyl Diphosphate Isomerase 2 3
  • Isopentenyl-Diphosphate Delta-Isomerase 2 3
  • EC 5.3.3.2 4

External Ids for IDI2 Gene

Previous GeneCards Identifiers for IDI2 Gene

  • GC10M001035
  • GC10M001018
  • GC10M001054
  • GC10M001004

Summaries for IDI2 Gene

GeneCards Summary for IDI2 Gene

IDI2 (Isopentenyl-Diphosphate Delta Isomerase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Terpenoid backbone biosynthesis. GO annotations related to this gene include hydrolase activity and isopentenyl-diphosphate delta-isomerase activity. An important paralog of this gene is IDI1.

UniProtKB/Swiss-Prot for IDI2 Gene

  • Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDI2 Gene

Genomics for IDI2 Gene

Regulatory Elements for IDI2 Gene

Genomic Location for IDI2 Gene

Chromosome:
10
Start:
1,018,907 bp from pter
End:
1,025,859 bp from pter
Size:
6,953 bases
Orientation:
Minus strand

Genomic View for IDI2 Gene

Genes around IDI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDI2 Gene

Proteins for IDI2 Gene

  • Protein details for IDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS1-IDI2_HUMAN
    Recommended name:
    Isopentenyl-diphosphate delta-isomerase 2
    Protein Accession:
    Q9BXS1

    Protein attributes for IDI2 Gene

    Size:
    227 amino acids
    Molecular mass:
    26753 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IDI2 Gene

neXtProt entry for IDI2 Gene

Proteomics data for IDI2 Gene at MOPED

Post-translational modifications for IDI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IDI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IDI2 Gene

Domains & Families for IDI2 Gene

Gene Families for IDI2 Gene

Suggested Antigen Peptide Sequences for IDI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXS1

UniProtKB/Swiss-Prot:

IDI2_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the IPP isomerase type 1 family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the IPP isomerase type 1 family.
genes like me logo Genes that share domains with IDI2: view

Function for IDI2 Gene

Molecular function for IDI2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Isopentenyl diphosphate = dimethylallyl diphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Enzyme Numbers (IUBMB) for IDI2 Gene

Gene Ontology (GO) - Molecular Function for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004452 isopentenyl-diphosphate delta-isomerase activity IDA 17202134
genes like me logo Genes that share ontologies with IDI2: view
genes like me logo Genes that share phenotypes with IDI2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IDI2 Gene

Localization for IDI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDI2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDI2 Gene COMPARTMENTS Subcellular localization image for IDI2 gene
Compartment Confidence
cytosol 5
peroxisome 5
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 17202134
genes like me logo Genes that share ontologies with IDI2: view

Pathways & Interactions for IDI2 Gene

genes like me logo Genes that share pathways with IDI2: view

UniProtKB/Swiss-Prot Q9BXS1-IDI2_HUMAN

  • Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.

Gene Ontology (GO) - Biological Process for IDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
GO:0050992 dimethylallyl diphosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with IDI2: view

No data available for SIGNOR curated interactions for IDI2 Gene

Drugs & Compounds for IDI2 Gene

(3) Drugs for IDI2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DIMETHYLALLYL DIPHOSPHATE Experimental Pharma Competitive, Inhibitor 0
Isopentenyl pyrophosphate Experimental Pharma 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with IDI2: view

Transcripts for IDI2 Gene

mRNA/cDNA for IDI2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IDI2 Gene

Isopentenyl-diphosphate delta isomerase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDI2 Gene

No ASD Table

Relevant External Links for IDI2 Gene

GeneLoc Exon Structure for
IDI2
ECgene alternative splicing isoforms for
IDI2

Expression for IDI2 Gene

mRNA expression in normal human tissues for IDI2 Gene

mRNA differential expression in normal tissues according to GTEx for IDI2 Gene

This gene is overexpressed in Muscle - Skeletal (x51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IDI2 Gene



SOURCE GeneReport for Unigene cluster for IDI2 Gene Hs.9270

mRNA Expression by UniProt/SwissProt for IDI2 Gene

Q9BXS1-IDI2_HUMAN
Tissue specificity: Detected in skeletal muscle.
genes like me logo Genes that share expression patterns with IDI2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for IDI2 Gene

Orthologs for IDI2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDI2 35
  • 99.27 (n)
  • 98.24 (a)
IDI2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9745 36
  • 66 (a)
OneToMany
Idi2 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IDI2 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564347 35
  • 75.18 (n)
  • 71.81 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii idi1 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5919 37
  • 42 (a)
CG5919 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea idi-1 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDI1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9971 36
  • 42 (a)
OneToMany
Species with no ortholog for IDI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IDI2 Gene

ENSEMBL:
Gene Tree for IDI2 (if available)
TreeFam:
Gene Tree for IDI2 (if available)

Paralogs for IDI2 Gene

Paralogs for IDI2 Gene

(1) SIMAP similar genes for IDI2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IDI2: view

Variants for IDI2 Gene

Sequence variations from dbSNP and Humsavar for IDI2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1044261 -- 1,019,770(+) CTCCC(C/T)AAATT reference, stop-gained
rs7918994 -- 1,019,972(+) ACCTC(A/G)ATTTT intron-variant
rs10159989 -- 1,019,310(+) CTGCA(A/G)CCAGG utr-variant-3-prime
rs10160004 -- 1,019,847(+) CAGAA(A/G)TTGGT intron-variant
rs7908239 -- 1,020,310(+) CTCTG(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDI2 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
dgv589n71 CNV Loss 21882294

Variation tolerance for IDI2 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDI2 Gene

HapMap Linkage Disequilibrium report
IDI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDI2 Gene

Disorders for IDI2 Gene

Relevant External Links for IDI2

Genetic Association Database (GAD)
IDI2
Human Genome Epidemiology (HuGE) Navigator
IDI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDI2

No disorders were found for IDI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDI2 Gene

Publications for IDI2 Gene

  1. IDI2, a second isopentenyl diphosphate isomerase in mammals. (PMID: 17202134) Clizbe D.B. … Krisans S.K. (J. Biol. Chem. 2007) 3 4 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. (PMID: 20955688) Kato T. … Matsubara K. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Type II isopentenyl diphosphate isomerase: irreversible inactivation by covalent modification of flavin. (PMID: 18345677) Rothman S.C. … Poulter C.D. (J. Am. Chem. Soc. 2008) 23

Products for IDI2 Gene

Sources for IDI2 Gene

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