IDI2 Gene
protein-coding GIFtS: 52
GCID: GC10M001064
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|
isopentenyl-diphosphate delta isomerase 2
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Aliases
for IDI2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Isopentenyl-Diphosphate Delta Isomerase 21 2 | | Diphosphate Dimethylallyl Diphosphate Isomerase 22 | | IPPI21 2 3 | | Isopentenyl-Diphosphate Delta-Isomerase 22 | | Isopentenyl Pyrophosphate Isomerase 22 3 | | EC 5.3.3.23 | | IPP Isomerase 22 3 | | |
Export aliases for IDI2 gene to outside databasesPrevious GC identifers: GC10M001035 GC10M001018 GC10M001054 GC10M001004 |
Summaries
for IDI2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highlyelectrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
|
Genomic Views
for IDI2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IDI2 gene promoter:
Max1 STAT1 STAT1beta STAT5A CUTL1 STAT1alpha PPAR-alpha NF-kappaB1 ATF6 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for IDI2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDI2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p15.3 Ensembl cytogenetic band: 10p15.3 HGNC cytogenetic band: 10p15.3IDI2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M001064: view genomic region
(about GC identifiers)
Start:
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1,064,847 bp from pter |
End:
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1,071,799 bp from pter |
Size:
|
6,953 bases |
Orientation:
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minus strand |
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Proteins
for IDI2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1 (See
protein sequence)Recommended Name: Isopentenyl-diphosphate Delta-isomerase 2 Size: 227 amino acids; 26753 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subcellular location: Peroxisome
1 PDB 3D structure from  and Proteopedia  for IDI2:2PNY (3D)
Explore the universe of human proteins at neXtProt for IDI2: NX_Q9BXS1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXS1
IDI2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_150286.1
ENSEMBL proteins: ENSP00000277517 Reactome Protein details: Q9BXS1
Human Recombinant Protein Products for IDI2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IDI2 for ontologies About GeneDecksing
IDI2 Antibody Products:
Assay Products for IDI2: |
Protein
Domains /
Families
for IDI2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IDI2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXS1ProtoNet protein and cluster: Q9BXS1 2 Blocks protein families: IPB000086 NUDIX hydrolase IPB002667 Isopentenyl-diphosphate delta-isomerase
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Similarity: Belongs to the IPP isomerase type 1 familySimilarity: Contains 1 nudix hydrolase domain |
Function
for IDI2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IDI2_HUMAN, Q9BXS1Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highlyelectrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)Catalytic activity: Isopentenyl diphosphate = dimethylallyl diphosphate Enzyme Number (IUBMB): EC 5.3.3.21
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
IDI2 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDI2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for IDI2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDI2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDI2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI2 |
|
Pathways & Interactions
for IDI2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | | | 3 | Cholesterol biosynthesis | | | 4 | trans, trans-farnesyl diphosphate biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for IDI2
3 
Reactome Pathways for IDI2
2 
Kegg Pathways (Kegg details for IDI2):
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyldiphosphate: step 1/1
IDI2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IDI2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for IDI2 (Q9BXS13 ENSP000002775174) via UniProtKB, MINT, STRING, and/or I2D
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006695 | cholesterol biosynthetic process |
TAS | -- | | GO:0008299 | isoprenoid biosynthetic process |
IDA | 17202134 | | GO:0044281 | small molecule metabolic process |
TAS | -- | | GO:0050992 | dimethylallyl diphosphate biosynthetic process |
IEA | -- |
IDI2 for ontologies About GeneDecksing
|
Drugs & Compounds
for IDI2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IDI2
3 HMDB Compounds for IDI2 About this table
Search CenterWatch for drugs/clinical trials and news about IDI2
|
Transcripts
for IDI2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IDI2 gene: NM_033261.2 Unigene Clusters for IDI2: Isopentenyl-diphosphate delta isomerase 2 Hs.9270 [show with all ESTs], Hs.591325 [show with all ESTs]Unigene Representative Sequences: BC040651, BC0177781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000277517(uc001ifv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDI2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDI2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for IDI2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IDI2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDI2 |
Additional cDNA sequence: AF271725.1 AK056950.1 BC017778.1 5 DOTS entries: DT.100751051 DT.110855 DT.95272315 DT.100702798 DT.92033109 17 AceView cDNA sequences: NM_033261 AK056950 BF670552 BC017778 F00114 BG183145 BX500308 AA197141 BG184320 BM751331 BG217172 AA197116 AF271725 CA313071 BG211295 BG187975 F00607
GeneLoc Exon Structure
|
Expression
for IDI2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IDI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACACAATGT
About this image
See IDI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IDI2
SOURCE GeneReport for Unigene clusters: Hs.9270 Hs.591325
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Tissue specificity: Detected in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including IDI2: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDI2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IDI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDI2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI2 |
Orthologs
for IDI2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for IDI2 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG59193 |
isopentenyl-diphosphate delta-isomerase |
42(a) |
|
93D2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
idi-16 |
Isopentenyl Diphosphate Isomerase family member (i... |
31(a) |
1 → many |
III(8091640-8092977) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
IPP26IPP16 |
Isopentenyl-diphosphate Delta-isomerase I |
36(a)36(a) |
many ↔ manymany ↔ many |
3(602433-604684) 5(5371627-5373735) |
rice
(Oryza sativa) |
Liliopsida |
--IPI16 |
hydrolase, NUDIX family, domain containing protein...hydrolase, NUDIX family, domain containing protein... |
40(a)34(a) |
many ↔ manymany ↔ many |
7(21624626-21627833) 5(20147794-20151060) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
idi6 |
isopentenyl diphosphate isomerase |
24(a) |
1 → many |
Chromosome(3031087-3031635) |
ENSEMBL Gene Tree for IDI2 (if available)
TreeFam Gene Tree for IDI2 (if available) |
Paralogs
for IDI2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IDI2 gene
- IDI12
1 SIMAP similar gene for IDI2 using alignment to 1 protein entry: IDI2_HUMAN:IDI1
IDI2 for paralogs About GeneDecksing
|
Genomic Variants
for IDI2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IDI2 (1064847 - 1071799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IDI2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDI2 |
|
Disorders
/ Diseases
for IDI2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IDI2 for disorders About GeneDecksing
6  diseases for IDI2: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis alzheimer's disease cholesterol
tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: IDI2 (1 document)
Export disorders for IDI2 gene to outside databases
|
Publications
for IDI2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IDI2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with IDI2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- IDI2, a second isopentenyl diphosphate isomerase in mammals. (PubMed id 17202134)1, 2, 9 Clizbe D.B.... Krisans S.K. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Segmental copy-number gain within the region of isope ntenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. (PubMed id 20955688)1 Kato T....Matsubara K. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PubMed id 16147992)1 Miles R.R....Elenitoba-Johnson K.S. (2005)
- Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. (PubMed id 14629038)1 Breitling R....Krisans S.K. (2003)
|
External Searches for IDI2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IDI2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IDI2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IDI2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IDI2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IDI2 gene:
Search GeneIP for patents involving IDI2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IDI2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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|
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