 |
 | Services
| |
 |
Aliases & Descriptions for IDI2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 5.3.3.2 3 | | IPPI2 1, 2, 3 | | OTTHUMP00000018952 2 |
| | | Descriptions |
|---|
| IPP isomerase 2 3 | | Isopentenyl pyrophosphate isomerase 2 3 | | diphosphate dimethylallyl diphosphate isomerase 2 2 | | isopentenyl-diphosphate delta isomerase 2 2 |
|
| | Search outside databases for aliases for IDI2 genePrevious GC identifers: GC10M001035 GC10M001018 |
Summaries for IDI2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) |
Genomic Location for IDI2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IDI2 gene 
Entrez Gene cytogenetic band: 10p15.3 Ensembl cytogenetic band: 10p15.3 HGNC cytogenetic band: 10p15.3IDI2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M001054:
(about GC identifiers)
Start:
|
1,054,847 bp from pter |
End:
|
1,061,799 bp from pter |
Size:
|
6,953 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_077567.3
| Proteins for IDI2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1 (See
protein sequence)Recommended Name: Isopentenyl-diphosphate Delta-isomerase 2 Size: 227 amino acids; 26753 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subcellular location: Peroxisome
PDB structures from and Proteopedia :2PNY (3D)
 REFSEQ proteins: NP_150286.1
ENSEMBL proteins: ENSP00000277517
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IDI2: Assays for IDI2: | Protein
Domains/ Families for IDI2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BXS1
ProtoNet protein and cluster: Q9BXS1 2 Blocks protein families: IPB000086 NUDIX hydrolase IPB002667 Isopentenyl-diphosphate delta-isomerase
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Similarity: Belongs to the IPP isomerase type 1 family | Gene Function for IDI2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033261
Applied Biosystems Silencer® siRNAs for IDI2
Sigma-Aldrich siRNA for IDI2  Sigma-Aldrich shRNA for IDI2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033261                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033261                                  untagged cDNA clone in CMV expression vector: NM_033261 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033261
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)Catalytic activity: Isopentenyl diphosphate = dimethylallyl diphosphateEnzyme Number (IUBMB): EC 5.3.3.2 4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
IEA | -- | | GO:0004452 | isopentenyl-diphosphate delta-isomerase activity |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- | | GO:0016853 | isomerase activity |
IEA | -- | About this table | Pathways & Interactions for IDI2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for IDI2 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Pathway: Isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from isopentenyl-PP: step 1/1 5/6 Interacting proteins for IDI2 (ENSP000002775173) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006695 | cholesterol biosynthetic process |
IEA | -- | | GO:0008299 | isoprenoid biosynthetic process |
IEA | -- | | GO:0016117 | carotenoid biosynthetic process |
IEA | -- | About this table
|
Drugs & Compounds for IDI2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IDI2
|
Transcripts for IDI2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033261
Sigma-Aldrich siRNA for IDI2  Sigma-Aldrich shRNA for IDI2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_033261 REFSEQ mRNAs for IDI2 gene: NM_033261.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033261               OriGene GFP tagged cDNA clone in CMV expression vector: NM_033261                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033261                                  untagged cDNA clone in CMV expression vector: NM_033261  Additional cDNA sequence: AF271725.1 AK056950.1 BC017778.1 5 DOTS entries: DT.100751051 DT.110855 DT.95272315 DT.100702798 DT.92033109 17 AceView cDNA sequences:AK056950 NM_033261 AA197141 BX500308 BF670552 BG184320 BC017778 BM751331 BG183145 F00114 AF271725 AA197116 BG217172 CA313071 F00607 BG187975 BG211295
highest scoring ESTs for IDI2:AK056950 BC017778 BF670552 AA197116 AF271725 BX500308 F00114 F00607 NM_033261 BF751754 Unigene Clusters for IDI2: Isopentenyl-diphosphate delta isomerase 2 Hs.9270 [show with all ESTs], Hs.591325 [show with all ESTs]Unigene Representative Sequences: BC040651, BC017778
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000277517
|
Expression for IDI2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IDI2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IDI2
1 / 2 / 3 5 probe-sets matching IDI2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTTTTCTTTT
SOURCE GeneReport for Unigene clusters: Hs.9270 Hs.591325 UniProtKB/Swiss-Prot: IDI2_HUMAN, Q9BXS1Tissue specificity: Detected in skeletal muscle |
Orthologs for IDI2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IDI2 gene from 4 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
IDI21 |
-- |
isopentenyl-diphosphate delta isomerase 2 |
99.27(n) 98.24(a) |
450262 XM_507621.2 XP_507621.2 |
rat (Rattus norvegicus) |
Idi2l1 |
-- |
isopentenyl-diphosphate delta isomerase 2-like |
75.33(n) 72.69(a) |
689815 XM_001072122.1 XP_001072122.1 |
mouse (Mus musculus) |
Idi25 |
13 |
isopentenyl-diphosphate delta isomerase 2 |
-- |
BC138100 |
fruit fly (Drosophila melanogaster) |
CG59193 |
93D2 |
isopentenyl-diphosphate delta-isomerase |
42(a) |
-- |
About this table Species with no ortholog for IDI2
ENSEMBL Gene Tree for IDI2 | Paralogs for IDI2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IDI2 gene
- IDI12
|
SNPs/Variants for IDI2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IDI2 (up to first 250kb)
|
Disorders & Mutations for IDI2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for IDI2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IDI2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for IDI2 gene:- IDI2, a second isopentenyl diphosphate isomerase in mammals. (PubMed id 17202134)1, 3, 4 Clizbe D.B.... Krisans S.K. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)2, 3 Strausberg R.L....Marra M.A. (2002)
- Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. (PubMed id 14629038)3 Breitling R....Krisans S.K. (2003)
- Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. (PubMed id 8806705)3 Hahn F.M.... Poulter C.D. (1996)
- Type II isopentenyl diphosphate isomerase: irreversible inactivation by covalent modification of flavin. (PubMed id 18345677)1 Rothman S.C....Poulter C.D. (2008)
- The diverse roles of flavin coenzymes--nature's most versatile thespians. (PubMed id 17580897)1 Mansoorabadi S.O....Liu H.W. (2007)
- Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. (PubMed id 15206931)1 Laupitz R....Rohdich F. (2004)
|
Search for IDI2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IDI2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IDI2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IDI2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IDI2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IDI2:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (IDI2) | | Antibodies (IDI2) |
| | | Search Tocris compounds for IDI2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|