Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IDI1 Gene

Aliases for IDI1 Gene

  • Isopentenyl-Diphosphate Delta Isomerase 1 2 3 5
  • Isopentenyl Pyrophosphate Isomerase 1 3 4
  • IPP Isomerase 1 3 4
  • EC 5.3.3.2 4 63
  • IPPI1 3 4
  • Isopentenyl Diphosphate Dimethylallyl Diphosphate Isomerase 1 3
  • Isopentenyl-Diphosphate Delta Isomerase 2
  • IPP Isomerase 2
  • IPP1 3

External Ids for IDI1 Gene

Previous GeneCards Identifiers for IDI1 Gene

  • GC10M001056
  • GC10M001039

Summaries for IDI1 Gene

Entrez Gene Summary for IDI1 Gene

  • IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDI1 Gene

IDI1 (Isopentenyl-Diphosphate Delta Isomerase 1) is a Protein Coding gene. Diseases associated with IDI1 include neonatal adrenoleukodystrophy. Among its related pathways are Metabolism and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include hydrolase activity and manganese ion binding. An important paralog of this gene is IDI2.

UniProtKB/Swiss-Prot for IDI1 Gene

  • Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDI1 Gene

Genomics for IDI1 Gene

Regulatory Elements for IDI1 Gene

Promoters for IDI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IDI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IDI1 Gene

Chromosome:
10
Start:
1,039,908 bp from pter
End:
1,056,699 bp from pter
Size:
16,792 bases
Orientation:
Minus strand

Genomic View for IDI1 Gene

Genes around IDI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDI1 Gene

Proteins for IDI1 Gene

  • Protein details for IDI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13907-IDI1_HUMAN
    Recommended name:
    Isopentenyl-diphosphate Delta-isomerase 1
    Protein Accession:
    Q13907
    Secondary Accessions:
    • B4E155
    • Q32Q13
    • Q53GQ6
    • Q86U81
    • Q8WUX8
    • Q96IZ4
    • Q9BQ74

    Protein attributes for IDI1 Gene

    Size:
    227 amino acids
    Molecular mass:
    26319 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH57827.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK29357.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK49434.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK49435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP35407.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA34890.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IDI1 Gene

    Alternative splice isoforms for IDI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDI1 Gene

Proteomics data for IDI1 Gene at MOPED

Post-translational modifications for IDI1 Gene

  • Ubiquitination at Lys 113, Lys 169, Lys 180, Lys 192, and Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for IDI1 Gene

Domains & Families for IDI1 Gene

Gene Families for IDI1 Gene

Suggested Antigen Peptide Sequences for IDI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13907

UniProtKB/Swiss-Prot:

IDI1_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the IPP isomerase type 1 family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the IPP isomerase type 1 family.
genes like me logo Genes that share domains with IDI1: view

Function for IDI1 Gene

Molecular function for IDI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Isopentenyl diphosphate = dimethylallyl diphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Enzyme Numbers (IUBMB) for IDI1 Gene

Gene Ontology (GO) - Molecular Function for IDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004452 isopentenyl-diphosphate delta-isomerase activity IEA --
genes like me logo Genes that share ontologies with IDI1: view
genes like me logo Genes that share phenotypes with IDI1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDI1 Gene

Localization for IDI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDI1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDI1 Gene COMPARTMENTS Subcellular localization image for IDI1 gene
Compartment Confidence
cytosol 5
peroxisome 5
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 17180682
genes like me logo Genes that share ontologies with IDI1: view

Pathways & Interactions for IDI1 Gene

genes like me logo Genes that share pathways with IDI1: view

UniProtKB/Swiss-Prot Q13907-IDI1_HUMAN

  • Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.

Interacting Proteins for IDI1 Gene

Gene Ontology (GO) - Biological Process for IDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050992 dimethylallyl diphosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with IDI1: view

No data available for SIGNOR curated interactions for IDI1 Gene

Drugs & Compounds for IDI1 Gene

(6) Drugs for IDI1 Gene - From: HMDB, Novoseek, IUPHAR, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DIMETHYLALLYL DIPHOSPHATE Experimental Pharma Competitive, Inhibitor, Target 0
Isopentenyl pyrophosphate Experimental Pharma 0
NE21650 Pharma Inhibition, Inhibitor 0
Magnesium Nutra 0

(1) Additional Compounds for IDI1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IDI1: view

Transcripts for IDI1 Gene

Unigene Clusters for IDI1 Gene

Isopentenyl-diphosphate delta isomerase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IDI1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for IDI1 Gene

GeneLoc Exon Structure for
IDI1
ECgene alternative splicing isoforms for
IDI1

Expression for IDI1 Gene

mRNA expression in normal human tissues for IDI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IDI1 Gene

This gene is overexpressed in Fetal testis (21.1) and Fetal Liver (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IDI1 Gene



SOURCE GeneReport for Unigene cluster for IDI1 Gene Hs.283652

genes like me logo Genes that share expression patterns with IDI1: view

Protein tissue co-expression partners for IDI1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IDI1 Gene

Orthologs for IDI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IDI1 35
  • 76.88 (n)
  • 76.41 (a)
IDI1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDI1 35
  • 87.2 (n)
  • 91.39 (a)
IDI1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idi1 35
  • 80.68 (n)
  • 79.51 (a)
Idi1 16
Idi1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IDI1 35
  • 99.06 (n)
  • 98.94 (a)
IDI1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Idi1 35
  • 79.95 (n)
  • 79.36 (a)
oppossum
(Monodelphis domestica)
Mammalia IDI1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDI1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDI1 35
  • 69.63 (n)
  • 72.24 (a)
-- 36
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia idi1 35
  • 71.51 (n)
  • 76.65 (a)
Str.12004 35
zebrafish
(Danio rerio)
Actinopterygii idi1 35
  • 69.46 (n)
  • 75.33 (a)
idi1 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5919 37
  • 49 (a)
CG5919 35
  • 51.32 (n)
  • 50.23 (a)
CG5919 36
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001704 35
  • 55.3 (n)
  • 49.53 (a)
worm
(Caenorhabditis elegans)
Secernentea K06H7.9 37
  • 38 (a)
idi-1 36
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL268C 35
  • 52.12 (n)
  • 51.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00924g 35
  • 60 (n)
  • 55.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDI1 35
  • 55.97 (n)
  • 53.02 (a)
IDI1 36
  • 40 (a)
OneToMany
IDI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons IPP2 35
  • 57.86 (n)
  • 53.3 (a)
rice
(Oryza sativa)
Liliopsida Os.18877 35
Os07g0546000 35
  • 55.09 (n)
  • 53.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3020 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07719 35
  • 55.11 (n)
  • 54.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes idi1 35
  • 57.34 (n)
  • 52.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9971 36
  • 50 (a)
OneToMany
Species with no ortholog for IDI1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDI1 Gene

ENSEMBL:
Gene Tree for IDI1 (if available)
TreeFam:
Gene Tree for IDI1 (if available)

Paralogs for IDI1 Gene

Paralogs for IDI1 Gene

(1) SIMAP similar genes for IDI1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IDI1 Gene

genes like me logo Genes that share paralogs with IDI1: view

Variants for IDI1 Gene

Sequence variations from dbSNP and Humsavar for IDI1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1135416 -- 1,045,368(-) ATTAT(A/T)ATTCA intron-variant
rs2472533 -- 1,045,623(-) CTGGC(A/G)TGGTG intron-variant
rs2387214 -- 1,049,472(+) CCCCC(C/T)CCCCC intron-variant, upstream-variant-2KB
rs2387215 -- 1,049,473(+) CCCCT(C/T)CCCCC intron-variant, upstream-variant-2KB
rs2387216 -- 1,053,676(+) aagag(A/G)tgtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDI1 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
dgv589n71 CNV Loss 21882294
nsv5532 CNV Loss 18451855
nsv894724 CNV Loss 21882294
esv2156728 CNV Deletion 18987734
esv2483699 CNV Deletion 19546169
nsv512136 CNV Loss 21212237
esv2729373 CNV Deletion 23290073
esv990965 CNV Deletion 20482838
esv2729384 CNV Deletion 23290073
esv2729395 CNV Deletion 23290073

Variation tolerance for IDI1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDI1 Gene

HapMap Linkage Disequilibrium report
IDI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDI1 Gene

Disorders for IDI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IDI1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neonatal adrenoleukodystrophy
  • adrenoleukodystrophy autosomal neonatal form
- elite association - COSMIC cancer census association via MalaCards
Search IDI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IDI1

Genetic Association Database (GAD)
IDI1
Human Genome Epidemiology (HuGE) Navigator
IDI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDI1
genes like me logo Genes that share disorders with IDI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IDI1 Gene

Publications for IDI1 Gene

  1. A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase. (PMID: 8020941) Xuan J.W. … Denhardt D.T. (Genomics 1994) 2 3 4 67
  2. The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis. (PMID: 17250851) Zheng W. … Rao Z. (J. Mol. Biol. 2007) 3 23
  3. Copper induces the expression of cholesterogenic genes in human macrophages. (PMID: 12860252) Svensson P.A. … Carlsson B. (Atherosclerosis 2003) 3 23
  4. Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. (PMID: 8806705) Hahn F.M. … Poulter C.D. (Arch. Biochem. Biophys. 1996) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IDI1 Gene

Sources for IDI1 Gene

Back to Top

Content