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IDI1 Gene

protein-coding   GIFtS: 64
GCID: GC10M001075

Isopentenyl-Diphosphate Delta Isomerase 1

(Previous name: isopentenyl-diphosphate delta isomerase)
  See IDI1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isopentenyl-Diphosphate Delta Isomerase 11 2     IPP Isomerase1
Isopentenyl Pyrophosphate Isomerase 12 3     Isopentenyl-Diphosphate Delta Isomerase1
IPPI12 3     IPP12
IPP Isomerase 12 3     Isopentenyl Diphosphate Dimethylallyl Diphosphate Isomerase 12
EC 5.3.3.23 8     Isopentenyl-Diphosphate Delta-Isomerase 12

External Ids:    HGNC: 53871   Entrez Gene: 34222   Ensembl: ENSG000000670647   OMIM: 6040555   UniProtKB: Q139073   

Export aliases for IDI1 gene to outside databases

Previous GC identifers: GC10M001056 GC10M001039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IDI1 Gene:
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP)
to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the
successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has
been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that
there is reduction in IPP isomerase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for IDI1 Gene:
IDI1 (isopentenyl-diphosphate delta isomerase 1) is a protein-coding gene. Diseases associated with IDI1 include neonatal adrenoleukodystrophy. GO annotations related to this gene include manganese ion binding and magnesium ion binding. An important paralog of this gene is IDI2.

UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907
Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly
electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IDI1 gene promoter:
         Elk-1   LHX3b/Lhx3b   CUTL1   NF-kappaB   NF-kappaB2   LHX3a/Lhx3a   aMEF-2   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): IDI1 promoter sequence
   Search Chromatin IP Primers for IDI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.3   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p15.3

IDI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDI1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M001075:  view genomic region     (about GC identifiers)

Start:
1,085,848 bp from pter      End:
1,095,110 bp from pter
Size:
9,263 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907 (See protein sequence)
Recommended Name: Isopentenyl-diphosphate Delta-isomerase 1  
Size: 227 amino acids; 26319 Da
Cofactor: Binds 1 magnesium ion per subunit
Subunit: Monomer
Sequence caution: Sequence=AAH57827.1; Type=Erroneous initiation; Sequence=AAK29357.1; Type=Erroneous initiation;
Sequence=AAK49434.1; Type=Erroneous initiation; Sequence=AAK49435.1; Type=Erroneous initiation;
Sequence=AAP35407.1; Type=Erroneous initiation; Sequence=CAA34890.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for IDI1:
2DHO (3D)        2I6K (3D)        2ICJ (3D)        2ICK (3D)    
Secondary accessions: B4E155 Q32Q13 Q53GQ6 Q86U81 Q8WUX8 Q96IZ4 Q9BQ74
Alternative splicing: 2 isoforms:  Q13907-1   Q13907-2   (Ref.8 (AAI07894) sequence is in conflict in position: 39:V->G)

Explore the universe of human proteins at neXtProt for IDI1: NX_Q13907

Explore proteomics data for IDI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys113, Lys169, Lys180, Lys192, Lys223
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IDI1 (Q13907) (see all 6)
     LLLQQRS  NTCCSHP  FLFKWWD  IGAETKKNCHLNENIE 


    See IDI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004499.2  
    ENSEMBL proteins: 
     ENSP00000370748   ENSP00000404771   ENSP00000401879  
    Reactome Protein details: Q13907

    IDI1 Human Recombinant Protein Products:

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    antibodies-online proteins for IDI1 (10 products) 

     
    antibodies-online peptides for IDI1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: isopentenyl-diphosphate Delta-isomerase 1
    Lanosterol biosynthesis pathway

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR011876 IsopentenylPP_isomerase_typ1
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q13907

    ProtoNet protein and cluster: Q13907

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB002667 Isopentenyl-diphosphate delta-isomerase


    UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907
    Similarity: Belongs to the IPP isomerase type 1 family
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with IDI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDI1_HUMAN, Q13907
    Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly
    electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
    Catalytic activity: Isopentenyl diphosphate = dimethylallyl diphosphate

         Enzyme Number (IUBMB): EC 5.3.3.21 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA17250851
    GO:0004452isopentenyl-diphosphate delta-isomerase activity IEA--
    GO:0016787hydrolase activity IEA--
    GO:0030145manganese ion binding IDA17250851
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with IDI1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IDI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IDI1:
    hsa-mir-215-5p (MIRT024849), hsa-mir-193b-3p (MIRT016465), hsa-let-7b-5p (MIRT032320), hsa-mir-26b-5p (MIRT029567), hsa-mir-192-5p (MIRT026527)

    Block miRNA regulation of human, mouse, rat IDI1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IDI1:
    hsa-miR-33a* hsa-miR-2052 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidIDI1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IDI1

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    GenScript: all cDNA clones in your preferred vector: IDI1 (NM_004508)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IDI1_HUMAN, Q13907: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol4
    mitochondrion3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA17180682
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IDI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IDI1 About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of cholesterol biosynthesis
    superpathway of cholesterol biosynthesis0.85
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)0.00
    Cholesterol biosynthesis0.85
    mevalonate pathway I0.00
    Cholesterol biosynthesis0.62
    trans, trans-farnesyl diphosphate biosynthesis0.00
    Terpenoid backbone biosynthesis0.34
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    Activation of Gene Expression by SREBP (SREBF)0.75
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with IDI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for IDI1 (see all 7)
        Cholesterol biosynthesis
    Diurnally regulated genes with circadian orthologs
    SREBP signalling
    mevalonate pathway I
    trans, trans-farnesyl diphosphate biosynthesis

    2 Reactome Pathways for IDI1
        Cholesterol biosynthesis
    Activation of gene expression by SREBF (SREBP)


    2 Kegg Pathways  (Kegg details for IDI1):
        Terpenoid backbone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907
    Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from
    isopentenyl diphosphate: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including IDI1: 

              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IDI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for IDI1 (Q139073 ENSP000003707484) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    HSPA8P111423I2D: score=4 
    RFT1Q96AA33I2D: score=4 
    USO1O607633I2D: score=4 
    NEDD4LQ96PU53I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0008299isoprenoid biosynthetic process IEA--
    GO:0035634response to stilbenoid IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0050992dimethylallyl diphosphate biosynthetic process IEA--

    Find genes that share ontologies with IDI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IDI1

    3 HMDB Compounds for IDI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylallylpyrophosphate1,1-Dimethyl-4-phenylpiperazinium iodide (see all 24)358-72-5--
    Isopentenyl pyrophosphate3-Methyl-3-butenyl pyrophosphate (see all 13)358-71-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for IDI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dimethylallyl Diphosphate-- 358-72-5target--10592235

    1 IUPHAR Ligand for IDI1 (isopentenyl-diphosphate Delta-isomerase 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    NE21650
    InhibitorInhibition4.211785983

    4 Novoseek inferred chemical compound relationships for IDI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dimethylallyl diphosphate 92.5 1 15381396 (1)
    isopentenyl diphosphate 92.2 15 8806705 (2), 15381396 (2), 17250851 (2), 7908830 (1) (see all 8)
    mevalonate 70.2 4 15206931 (1), 15381396 (1), 8739963 (1)
    cholesterol 21.7 7 16020911 (1), 17478552 (1), 8739963 (1)



    Find genes that share compounds with IDI1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IDI1 gene: 
    NM_004508.2  

    Unigene Cluster for IDI1:

    Isopentenyl-diphosphate delta isomerase 1
    Hs.283652  [show with all ESTs]
    Unigene Representative Sequence: BX537663
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381344(uc001ifz.3 uc001iga.3 uc001igb.3 uc001igc.3)
    ENST00000491735 ENST00000427898 ENST00000429642 ENST00000482091
    miRNA
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    hsa-miR-33a* hsa-miR-2052 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidIDI1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IDI1

    Additional mRNA sequence: 

    AF271720.1 AK222875.1 AK303669.1 AK311110.1 BC005247.2 BC006999.2 BC019227.2 BC022418.2 
    BC025375.2 BC057827.1 BC107893.1 BT006761.1 BX537663.1 BX648472.1 X17025.1 

    Selected DOTS entries (see all 36):

    DT.92462703  DT.99994257  DT.453773  DT.91911776  DT.100723192  DT.408305  DT.97838100  DT.100883548 
    DT.100883542  DT.95363710  DT.92462695  DT.100746628  DT.100000543  DT.100883547  DT.121257168  DT.100883544 
    DT.100883550  DT.419678  DT.75101189  DT.121257216  DT.121257271  DT.95363709  DT.97860180  DT.101980739 

    Selected AceView cDNA sequences (see all 719):

    CR624844 F02500 BQ776340 AA400048 CR600177 AI380146 AI799723 BM127991 
    AI564076 AW105497 CR605332 CR614669 BM720677 BM666561 CR625468 AI086489 
    AA460279 BQ012944 BF447579 BU625760 CA432337 BM127742 CR620656 AI686203 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IDI1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                    -                                             
    SP2:                    -     -     -                                 
    SP3:                          -     -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for IDI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IDI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACACCCAC
    IDI1 Expression
    About this image


    IDI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    IDI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IDI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283652
        Pathway & Disease-focused RT2 Profiler PCR Array including IDI1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IDI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IDI1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Idi11 , 5 isopentenyl-diphosphate delta isomerase1, 5 80.68(n)1
    79.51(a)1
      13 (3.62 cM)5
    3195541  NM_145360.21  NP_663335.21 
     88855015 
    chicken
    (Gallus gallus)
    Aves IDI11 isopentenyl-diphosphate delta isomerase 1 69.63(n)
    72.24(a)
      420459  XM_004939167.1  XP_004939224.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    1 → many
    6(8112544-8117708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120042 Transcribed sequence with moderate similarity to protein more 74(n)    CF524263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idi11 isopentenyl-diphosphate delta isomerase 1 69.46(n)
    75.33(a)
      553513  NM_001025475.1  NP_001020646.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59191 , 3 isopentenyl-diphosphate
    delta-isomerase3
    CG59191
    49(a)3
    51.32(n)1
    50.23(a)1
      93D23
    425261  NM_142705.21  NP_650962.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K06H7.93   -- 38(a)   III(8163455-8164664)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IDI1(YPL117C)4
    IDI11
    Isopentenyl diphosphate:dimethylallyl diphosphate isomerase more4
    IDI11
    55.97(n)1
    53.02(a)1
      16(328730-327864)4
    8559861, 4  NP_015208.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IPP21 IPP2 57.86(n)
    53.3(a)
      820960  NM_111146.3  NP_186927.1 
    rice
    (Oryza sativa)
    Liliopsida Os.188772 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.54(n)    AK060336.1 


    ENSEMBL Gene Tree for IDI1 (if available)
    TreeFam Gene Tree for IDI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IDI1 gene
    IDI22  
    1 SIMAP similar gene for IDI1 using alignment to 3 protein entries:     IDI1_HUMAN (see all proteins):
    IDI2

    Find genes that share paralogs with IDI1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for IDI1
    PGOHUM00000247433 PGOHUM00000240964 PGOHUM00000249333


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IDI1 (see all 167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394464631,2
    --1090663(+) TTTCTC/GAACCC 1 -- int10--------
    rs676964501,2
    C,F--1090684(+) GTTATC/TAGAAA 1 -- int14Minor allele frequency- T:0.22NA 126
    rs766877891,2
    C--1090724(+) CCCAGA/GACAGT 1 -- int10--------
    rs1831695601,2
    --1090780(+) TTATAC/TTCAAT 1 -- int10--------
    rs1454910531,2
    --1090790(+) TAGATA/GCTTTA 1 -- int10--------
    rs1484267281,2
    --1090877(+) AGGCAA/GTAGGT 1 -- int10--------
    rs122579491,2
    H--1090906(+) actgaG/Ctgtgg 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1451789941,2
    --1090967(+) ACAAAA/GTATTT 1 -- int10--------
    rs1476089941,2
    --1090986(+) CTCCAA/TCCGTT 1 -- int10--------
    rs70725541,2
    C,F,H--1090988(+) CCATCC/TGTTTA 1 -- int119Minor allele frequency- T:0.16NS EA NA WA 2344

    HapMap Linkage Disequilibrium report for IDI1 (1085848 - 1095110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IDI1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729395CNV Deletion23290073
    esv2660097CNV Deletion23128226
    esv2156728CNV Deletion18987734
    esv990965CNV Deletion20482838
    esv2729384CNV Deletion23290073
    esv2729373CNV Deletion23290073
    esv2483699CNV Deletion19546169
    nsv512136CNV Loss21212237
    nsv5532CNV Loss18451855
    dgv589n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IDI1
    DNA2.0 Custom Variant and Variant Library Synthesis for IDI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604055    OMIM disorders: --

    1 disease for IDI1:    
    About MalaCards
    neonatal adrenoleukodystrophy


    Find genes that share disorders with IDI1           About GenesLikeMe

    Genetic Association Database (GAD): IDI1
    Human Genome Epidemiology (HuGE) Navigator: IDI1 (3 documents)

    Export disorders for IDI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IDI1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with IDI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase. (PubMed id 8020941)1, 2, 3 Xuan J.W.... Denhardt D.T. (Genomics 1994)
    2. The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis. (PubMed id 17250851)1, 2, 9 Zheng W.... Rao Z. (J. Mol. Biol. 2007)
    3. Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. (PubMed id 8806705)1, 2, 9 Hahn F.M.... Poulter C.D. (Arch. Biochem. Biophys. 1996)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Copper induces the expression of cholesterogenic genes in human macrophages. (PubMed id 12860252)1, 9 Svensson P.A....Carlsson B. (Atherosclerosis 2003)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3422 HGNC: 5387 AceView: IDI1 Ensembl:ENSG00000067064 euGenes: HUgn3422
    ECgene: IDI1 Kegg: 3422 H-InvDB: IDI1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IDI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IDI1 gene:
    Search GeneIP for patents involving IDI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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