Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IDI1 Gene

protein-coding GIFtS: 62
GCID: GC10M001075

isopentenyl-diphosphate delta isomerase 1

(Previous name: isopentenyl-diphosphate delta isomerase )

Explore 11 diseases affiliated with
IDI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Isopentenyl-Diphosphate Delta Isomerase 1¹ ²		Isopentenyl-Diphosphate Delta Isomerase¹
Isopentenyl Pyrophosphate Isomerase 1² ³		IPP1²
IPPI1² ³		Isopentenyl Diphosphate Dimethylallyl Diphosphate Isomerase 1²
IPP Isomerase 1² ³		Isopentenyl-Diphosphate Delta-Isomerase 1²
EC 5.3.3.2³ ⁸

External Ids:	HGNC: 5387¹	Entrez Gene: 3422²	Ensembl: ENSG00000067064⁷	OMIM: 604055⁵	UniProtKB: Q13907³

Export aliases for IDI1 gene to outside databases

Previous GC identifers: GC10M001056 GC10M001039

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDI1:

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to

its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive

reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in

peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction

in IPP isomerase activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907

Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly

electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IDI1 gene promoter:
Elk-1 LHX3b/Lhx3b CUTL1 NF-kappaB NF-kappaB2 LHX3a/Lhx3a aMEF-2 NF-kappaB1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): IDI1 promoter sequence

Search SABiosciences Chromatin IP Primers for IDI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.3 Ensembl cytogenetic band: 10p15.3 HGNC cytogenetic band: 10p15.3

IDI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDI1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M001075: view genomic region (about GC identifiers)

Start:	1,085,848 bp from pter	End:	1,095,110 bp from pter
Size:	9,263 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907 (See protein sequence)

Recommended Name: Isopentenyl-diphosphate Delta-isomerase 1

Size: 227 amino acids; 26319 Da

Cofactor: Binds 1 magnesium ion per subunit

Subunit: Monomer

Subcellular location: Peroxisome

Sequence caution: Sequence=AAH57827.1; Type=Erroneous initiation; Sequence=AAK29357.1; Type=Erroneous initiation;

Sequence=AAK49434.1; Type=Erroneous initiation; Sequence=AAK49435.1; Type=Erroneous initiation; Sequence=AAP35407.1;

Type=Erroneous initiation; Sequence=CAA34890.1; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for IDI1:

2DHO (3D)

2I6K (3D)

2ICJ (3D)

2ICK (3D)

Secondary accessions: B4E155 Q32Q13 Q53GQ6 Q86U81 Q8WUX8 Q96IZ4 Q9BQ74

Alternative splicing: 2 isoforms: Q13907-1 Q13907-2 (Ref.8 (AAI07894) sequence is in conflict in position: 39:V->G)

Explore the universe of human proteins at neXtProt for IDI1: NX_Q13907

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13907

4/6 DME Specific Peptides for IDI1 (Q13907) (see all 6)

LLLQQRS

NTCCSHP

FLFKWWD

IGAETKKNCHLNENIE

IDI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004499.2

ENSEMBL proteins:

ENSP00000370748 ENSP00000404771 ENSP00000401879

Reactome Protein details: Q13907
Human Recombinant Protein Products for IDI1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IDI1 OriGene Custom Protein Services for IDI1
	GenScript Custom Purified and Recombinant Proteins Services for IDI1
	Novus Biologicals IDI1 Proteins Novus Biologicals IDI1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IDI1
	Uscn Proteins for IDI1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005777	peroxisome	IDA	17180682
GO:0005829	cytosol	TAS	--

IDI1 for ontologies About GeneDecksing

IDI1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: IDI1 OriGene Custom Antibody Services for IDI1
	GenScript Custom Superior Antibodies Services for IDI1
	Novus Biologicals IDI1 Antibodies
	Search for Antibodies for IDI1 at Abcam
	Uscn Antibodies for IDI1
	ThermoFisher Antibodies for IDI1

Assay Products for IDI1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IDI1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IDI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IDI1 for domains About GeneDecksing

3 InterPro domains/families:

IPR015797 NUDIX_hydrolase_dom-like

IPR011876 IsopentenylPP_isomerase_typ1

IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry Q13907

ProtoNet protein and cluster: Q13907

2 Blocks protein families:

IPB000086 NUDIX hydrolase

IPB002667 Isopentenyl-diphosphate delta-isomerase

UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907

Similarity: Belongs to the IPP isomerase type 1 family

Similarity: Contains 1 nudix hydrolase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IDI1_HUMAN, Q13907

Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly

electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)

Catalytic activity: Isopentenyl diphosphate = dimethylallyl diphosphate

Enzyme Number (IUBMB): EC 5.3.3.2¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	17250851
GO:0004452	isopentenyl-diphosphate delta-isomerase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0030145	manganese ion binding	IDA	17250851
GO:0046872	metal ion binding	IEA	--

IDI1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IDI1

miRNA Products:		OriGene 3'-UTR Clone: IDI1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDI1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IDI1:
		hsa-miR-33a* hsa-miR-2052 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: IDI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDI1 (see all 6) OriGene siRNA: IDI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDI1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IDI1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IDI1
			Sirion Biotech Customized adenovirus for overexpression of IDI1 Sirion Biotech Customized adenovirus for potent knockdown of IDI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IDI1 (NM_004508)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDI1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IDI1
		Search LifeMap BioReagents cell lines for IDI1
		Sirion Biotech Customized stable knockdown cell line services for IDI1 Sirion Biotech Customized inducible knockdown cell line services for IDI1 Sirion Biotech Customized stable overexpressing cell line services for IDI1 Sirion Biotech Customized inducible overexpressing cell line services for IDI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	1.00			Terpenoid backbone biosynthesis	0.71
	mevalonate pathway I	0.86

Cholesterol biosynthesis

	Cholesterol biosynthesis	1.00			Cholesterol Biosynthesis	0.68
	superpathway of cholesterol biosynthesis	0.81

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 BioSystems Pathways for IDI1 (see all 7)

	SREBP signalling
	Cholesterol Biosynthesis
	Diurnally regulated genes with circadian orthologs
	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	trans, trans-farnesyl diphosphate biosynthesis

5/6 Reactome Pathways for IDI1 (see all 6)

	Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
	Metabolism
	Cholesterol biosynthesis
	Activation of Gene Expression by SREBP (SREBF)
	Metabolism of lipids and lipoproteins

2 Kegg Pathways (Kegg details for IDI1):

	Terpenoid backbone biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: IDI1_HUMAN, Q13907

Pathway: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl

diphosphate: step 1/1

IDI1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IDI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/53 Interacting proteins for IDI1 (Q13907³ ENSP00000370748⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
HSPA8	P11142³	I2D: score=4
RFT1	Q96AA3³	I2D: score=4
USO1	O60763³	I2D: score=4
NEDD4L	Q96PU5³	I2D: score=3

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	TAS	--
GO:0008299	isoprenoid biosynthetic process	IEA	--
GO:0035634	response to stilbenoid	IEA	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0050992	dimethylallyl diphosphate biosynthetic process	IEA	--

IDI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IDI1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IDI1

3 HMDB Compounds for IDI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Dimethylallylpyrophosphate	1,1-Dimethyl-4-phenylpiperazinium iodide (see all 24)	358-72-5	--
Isopentenyl pyrophosphate	3-Methyl-3-butenyl pyrophosphate (see all 13)	358-71-4	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for IDI1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dimethylallyl Diphosphate	--	358-72-5	target	--	10592235

4 Novoseek chemical compound relationships for IDI1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dimethylallyl diphosphate	92.5	1	15381396 (1)
isopentenyl diphosphate	92.2	15	8806705 (2), 15381396 (2), 17250851 (2), 7908830 (1) (see all 8)
mevalonate	70.2	4	15206931 (1), 15381396 (1), 8739963 (1)
cholesterol	21.7	7	16020911 (1), 17478552 (1), 8739963 (1)

Search CenterWatch for drugs/clinical trials and news about IDI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IDI1 gene:

NM_004508.2

Unigene Cluster for IDI1:

Isopentenyl-diphosphate delta isomerase 1

Hs.743977 [show with all ESTs]

Unigene Representative Sequence: BX537663

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381344(uc001ifz.3 uc001iga.3 uc001igb.3 uc001igc.3)

ENST00000491735 ENST00000427898 ENST00000429642 ENST00000482091

miRNA Products:		OriGene 3'-UTR Clone: IDI1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IDI1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IDI1:
		hsa-miR-33a* hsa-miR-2052 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: IDI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDI1 (see all 6) OriGene siRNA: IDI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDI1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IDI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IDI1 (NM_004508)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDI1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IDI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDI1

Additional cDNA sequence:

AF271720.1 AK222875.1 AK303669.1 AK311110.1 BC005247.2 BC006999.2 BC019227.2 BC022418.2

BC025375.2 BC057827.1 BC107893.1 BT006761.1 BX537663.1 BX648472.1 X17025.1

24/31 DOTS entries (see all 31):

DT.92462703 DT.453773 DT.99994257 DT.91911776 DT.100723192 DT.408305 DT.97838100 DT.100883548

DT.100883542 DT.95363710 DT.92462695 DT.100000543 DT.100746628 DT.100883544 DT.100883550 DT.419678

DT.75101189 DT.100883547 DT.121257216 DT.121257271 DT.97860180 DT.121257265 DT.121257275 DT.121257321

24/719 AceView cDNA sequences (see all 719):

BM452536 BQ012944 AI432135 BI467239 BQ021407 CB161439 AI086489 BQ225771

CF552205 AI246474 AA782793 AI380146 CA395043 NM_004508 CA416874 BQ776340

BM726694 BM854259 AI925417 AI305202 AW001671 BU622307 F02500 CA432337

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IDI1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b
SP1:							-
SP2:							-		-		-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for IDI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IDI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACACCCAC

About this image

IDI1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IDI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IDI1

SOURCE GeneReport for Unigene cluster: Hs.743977

SABiosciences Expression via Pathway-Focused PCR Array including IDI1:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IDI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDI1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for IDI1 gene from 11/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Idi1^{1 , 5}	isopentenyl-diphosphate delta isomerase^{1, 5}	80.45(n)¹ 79.51(a)¹		13 (3.62 cM)⁵ 319554¹ NM_145360.2¹ NP_663335.2¹ 8885501⁵
chicken (Gallus gallus)	Aves	IDI1¹	isopentenyl-diphosphate delta isomerase 1	76.95(n) 82.82(a)		420459 XM_418561.3 XP_418561.3
lizard (Anolis carolinensis)	Reptilia	--	--	81(a)	1 ↔ 1	6(8112544-8115154)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12004²	Transcribed sequence with moderate similarity to protein more	74(n)		CF524263.1
zebrafish (Danio rerio)	Actinopterygii	idi1¹	isopentenyl-diphosphate delta isomerase 1	69.46(n) 75.33(a)		553513 NM_001025475.1 NP_001020646.1
fruit fly (Drosophila melanogaster)	Insecta	CG5919^{1 , 3}	isopentenyl-diphosphate delta-isomerase³ CG5919¹	49(a)³ 51.56(n)¹ 50.93(a)¹		93D2³ 42526¹ NM_142705.2¹ NP_650962.1¹
worm (Caenorhabditis elegans)	Secernentea	K06H7.9³	--	38(a)		III(8163455-8164664) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	IDI1(YPL117C)⁴ IDI1¹	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase more⁴ Idi1p¹	55.97(n)¹ 53.02(a)¹		16(328730-327864)⁴ 855986^{1, 4} NP_015208.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	IPP2¹	Isopentenyl-diphosphate Delta-isomerase II	58.45(n) 54.79(a)		820960 NM_111146.3 NP_186927.1
rice (Oryza sativa)	Liliopsida	Os.18877²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	74.54(n)		AK060336.1

ENSEMBL Gene Tree for IDI1 (if available)
TreeFam Gene Tree for IDI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IDI1 gene

IDI2²

1 SIMAP similar gene for IDI1 using alignment to 3 protein entries: IDI1_HUMAN (see all proteins):

IDI2

IDI1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for IDI1
PGOHUM00000247433 PGOHUM00000240964 PGOHUM00000249333

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4880758^1,2	C,F,A,H	--	1085572(+)	`CCTTAC/GATTTT`	5	--	ds500¹ int¹		16		NS EA NA WA	1406
rs182593111^1,2		--	1085787(+)	`TGCAAC/TGGAAA`	5	--	ds500¹ int¹		0	--	--	--	--
rs55879610^1,2	C	--	1086064(+)	`ATGGCA/GAGTTT`	5	--	int¹ ut3¹		0	--	--	--	--
rs1285^1,2	C,F,A,H	--	1086116(+)	`ATACAC/TATTCC`	5	--	ut3¹ int¹ ese³		17		MN NS EA NA CSA WA	2088
rs146383031^1,2		--	1086290(+)	`GGGACA/GCTGCT`	5	--	int¹ ut3¹		0	--	--	--	--
rs187708872^1,2		--	1086385(+)	`TTACCG/TAGTGG`	5	--	ut3¹ int¹		0	--	--	--	--
rs115475408^1,2		--	1086467(+)	`AAATAC/TTATTT`	5	--	ut3¹ int¹		1		WA	118
rs55868120^1,2	C	--	1086657(+)	`ATTAAA/GACTGT`	5	--	ut3¹ int¹		0	--	--	--	--
rs192746688^1,2		--	1086661(+)	`AGACTA/GTTTTG`	5	--	int¹ ut3¹		0	--	--	--	--
rs182456874^1,2		--	1086729(+)	`TGATAA/CATAAA`	5	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IDI1 (1085848 - 1095110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IDI1
1 CNV: 100825

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDI1

DNA2.0 Custom Variant and Variant Library Synthesis for IDI1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IDI1 for disorders           About GeneDecksing

OMIM gene information: 604055    OMIM disorders: --

11 diseases for IDI1:    About MalaCards

neonatal adrenoleukodystrophy zellweger syndrome adrenoleukodystrophy cholesterol

pyloric stenosis amyotrophic lateral sclerosis lateral sclerosis breast cancer

tuberculosis leukemia mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: IDI1 (3 documents)

Export disorders for IDI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IDI1 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with IDI1)

Utopia: connect your pdf to the dynamic
world of online information

A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase. (PubMed id 8020941)^{1, 2, 3} Xuan J.W.... Denhardt D.T. (1994)
The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis. (PubMed id 17250851)^{1, 2, 9} Zheng W.... Rao Z. (2007)
Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. (PubMed id 8806705)^{1, 2, 9} Hahn F.M.... Poulter C.D. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Copper induces the expression of cholesterogenic genes in human macrophages. (PubMed id 12860252)^{1, 9} Svensson P.A....Carlsson B. (2003)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3422	HGNC: 5387	AceView: IDI1	Ensembl:ENSG00000067064	euGenes: HUgn3422
ECgene: IDI1	Kegg: 3422	H-InvDB: IDI1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IDI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IDI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IDI1 gene:
Search GeneIP for patents involving IDI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for IDI1		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IDI1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IDI1
	OriGene Protein Over-expression Lysate for IDI1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IDI1		OriGene 3'-UTR Clone for IDI1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IDI1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IDI1		OriGene Custom Protein Services for IDI1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IDI1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IDI1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDI1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IDI1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IDI1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IDI1

	GenScript Custom Purified and Recombinant Proteins Services for IDI1		GenScript cDNA clones with any tag delivered in your preferred vector for IDI1
	GenScript Custom Assay Services for IDI1		GenScript Custom Superior Antibodies Services for IDI1
	GenScript Custom overexpressing Cell Line Services for IDI1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IDI1 promoter
	Search Chromatin IP Primers for IDI1
	RT² qPCR Primer Assay in human, mouse, rat IDI1
	Search GNC Networks for IDI1
	SABiosciences PCR Arrays including human, mouse, rat IDI1

Search Tocris compounds for IDI1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IDI1 antibodies
	IDI1 proteins
	IDI1 lysates

	Search for Antibodies for IDI1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IDI1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for IDI1

IDI1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IDI1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDI1

	SwitchGear 3'UTR luciferase reporter plasmids for IDI1
	SwitchGear Promoter luciferase reporter plasmids for IDI1

ThermoFisher Antibodies for IDI1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDI1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IDI1

Sirion Biotech Customized:

	stable knockdown cell line services for IDI1
	inducible knockdown cell line services for IDI1
	design and validation of potent shRNA sequences against IDI1
	adenovirus for potent knockdown of IDI1
	adenovirus for overexpression of IDI1
	stable overexpressing cell line services for IDI1
	inducible overexpressing cell line services for IDI1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IDI1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

IDI1 Gene

isopentenyl-diphosphate delta isomerase 1

Aliases
for IDI1 gene

Summaries
for IDI1 gene

Genomic Views
for IDI1 gene

Proteins
for IDI1 gene

Protein Domains /
Families
for IDI1 gene

Function
for IDI1 gene

Pathways & Interactions
for IDI1 gene

Drugs & Compounds
for IDI1 gene

Transcripts
for IDI1 gene

Expression
for IDI1 gene

Orthologs
for IDI1 gene

Paralogs
for IDI1 gene

Genomic Variants
for IDI1 gene

Disorders / Diseases
for IDI1 gene

Publications
for IDI1 gene

External Searches for IDI1 gene

Genome Databases showing IDI1 gene

Other Databases showing IDI1 gene

Specialized Databases showing IDI1 gene

Intellectual Property
for IDI1 gene

Products
for IDI1 gene

View Random Gene

Advanced Search

Export list of displayed genes

IDI1 Gene

isopentenyl-diphosphate delta isomerase 1

Aliasesfor IDI1 gene

Summariesfor IDI1 gene

Genomic Viewsfor IDI1 gene

Proteinsfor IDI1 gene

Protein Domains /Familiesfor IDI1 gene

Functionfor IDI1 gene

Pathways & Interactionsfor IDI1 gene

Drugs & Compoundsfor IDI1 gene

Transcriptsfor IDI1 gene

Expression for IDI1 gene

Orthologsfor IDI1 gene

Paralogsfor IDI1 gene

Genomic Variantsfor IDI1 gene

Disorders / Diseasesfor IDI1 gene

Publicationsfor IDI1 gene

External Searches for IDI1 gene

Genome Databases showing IDI1 gene

Other Databases showing IDI1 gene

Specialized Databases showing IDI1 gene

Intellectual Propertyfor IDI1 gene

Productsfor IDI1 gene

View Random Gene

Aliases
for IDI1 gene

Summaries
for IDI1 gene

Genomic Views
for IDI1 gene

Proteins
for IDI1 gene

Protein Domains /
Families
for IDI1 gene

Function
for IDI1 gene

Pathways & Interactions
for IDI1 gene

Drugs & Compounds
for IDI1 gene

Transcripts
for IDI1 gene

Expression
for IDI1 gene

Orthologs
for IDI1 gene

Paralogs
for IDI1 gene

Genomic Variants
for IDI1 gene

Disorders / Diseases
for IDI1 gene

Publications
for IDI1 gene

Intellectual Property
for IDI1 gene

Products
for IDI1 gene