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IDH3G Gene

protein-coding   GIFtS: 62
GCID: GC0XM153051

Isocitrate Dehydrogenase 3 (NAD+) Gamma

  See IDH3G-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isocitrate Dehydrogenase 3 (NAD+) Gamma1 2     Isocitrate Dehydrogenase [NAD] Subunit Gamma, Mitochondrial2
Isocitric Dehydrogenase Subunit Gamma2 3     Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit2
NAD(+)-Specific ICDH Subunit Gamma2 3     NAD (H)-Specific Isocitrate Dehydrogenase Gamma Subunit2
EC 1.1.1.413 8     NAD+-Specific ICDH2
H-IDHG2     EC 1.1.18
IDH-gamma2     

External Ids:    HGNC: 53861   Entrez Gene: 34212   Ensembl: ENSG000000678297   OMIM: 3000895   UniProtKB: P515533   

Export aliases for IDH3G gene to outside databases

Previous GC identifers: GC0XM147188 GC0XM149506 GC0XM150636 GC0XM151519 GC0XM152572 GC0XM152704 GC0XM141708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IDH3G Gene:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes
belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which
localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is
mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the
allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer
that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene
is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene
for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been
described, but only some of their full length natures have been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for IDH3G Gene:
IDH3G (isocitrate dehydrogenase 3 (NAD+) gamma) is a protein-coding gene. Diseases associated with IDH3G include periventricular heterotopia. GO annotations related to this gene include isocitrate dehydrogenase (NAD+) activity and magnesium ion binding. An important paralog of this gene is IDH3B.

Gene Wiki entry for IDH3G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IDH3G gene promoter:
         c-Fos   NF-1/L   NF-1   AP-1   Fra-1   FosB   FOXO1a   ZIC2/Zic2   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIDH3G promoter sequence
   Search Chromatin IP Primers for IDH3G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDH3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

IDH3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDH3G gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153051:  view genomic region     (about GC identifiers)

Start:
153,051,221 bp from pter      End:
153,059,978 bp from pter
Size:
8,758 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IDH3G_HUMAN, P51553 (See protein sequence)
Recommended Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor  
Size: 393 amino acids; 42794 Da
Cofactor: Binds 1 magnesium or manganese ion per subunit (By similarity)
Subunit: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity)
Secondary accessions: E9PDD5 Q9BUU5
Alternative splicing: 2 isoforms:  P51553-1   P51553-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IDH3G: NX_P51553

Explore proteomics data for IDH3G at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IDH3G (P51553) (see all 13)
     DILIVRE  VHKANIM  VMPNLYG  DGLFLQCC 


    See IDH3G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004126.1  NP_777358.1  

    ENSEMBL proteins: 
     ENSP00000359110   ENSP00000217901   ENSP00000400115   ENSP00000359111   ENSP00000408529  
     ENSP00000401862   ENSP00000402747  
    Reactome Protein details: P51553

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR004434 Isocitrate_DH_NAD
     IPR001804 Isocitrate/isopropylmalate_DH
     IPR019818 IsoCit/isopropylmalate_DH_CS
     IPR024084 IsoPropMal-DH-like_dom

    Graphical View of Domain Structure for InterPro Entry P51553

    ProtoNet protein and cluster: P51553

    1 Blocks protein domain: IPB001804 Isocitrate/isopropylmalate dehydrogenase

    UniProtKB/Swiss-Prot: IDH3G_HUMAN, P51553
    Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family


    Find genes that share domains with IDH3G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDH3G_HUMAN, P51553
    Catalytic activity: Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH
    Enzyme regulation: Activated by increasing ADP/ATP ratios and by Ca(2+) (By similarity)

         Genatlas biochemistry entry for IDH3G:
    isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in many tissues,catalyzing
    the third step of citric acid cycle,catalyzing the oxidative decarboxylation of isocitrate into
    alpha-ketoglutarate

         Enzyme Numbers (IUBMB): EC 1.1.1.411 2 EC 1.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004449isocitrate dehydrogenase (NAD+) activity ISS--
    GO:0005524ATP binding IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding IEA--
         
    Find genes that share ontologies with IDH3G           About GenesLikeMe


    Animal Models:
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    hsa-mir-320a (MIRT044581)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IDH3G_HUMAN, P51553: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with IDH3G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IDH3G About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citric acid cycle (TCA cycle)0.55
    conversion of glucose to acetyl CoA and entry into the TCA cycle0.43
    Citrate cycle (TCA cycle)0.55
    TCA Cycle0.00
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    TCA cycle0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Carbon metabolism
    Carbon metabolism0.38
    2-Oxocarboxylic acid metabolism0.00
    Biosynthesis of amino acids0.38
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with IDH3G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for IDH3G
        TCA Cycle
    TCA cycle
    conversion of glucose to acetyl CoA and entry into the TCA cycle


    2 Reactome Pathways for IDH3G
        Mitochondrial protein import
    Citric acid cycle (TCA cycle)


    5 Kegg Pathways  (Kegg details for IDH3G):
        Citrate cycle (TCA cycle)
    Metabolic pathways
    Carbon metabolism
    2-Oxocarboxylic acid metabolism
    Biosynthesis of amino acids

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDH3G: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IDH3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IDH3G (P515533 ENSP000002179014) via UniProtKB, MINT, STRING, and/or I2D (see all 222)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS9286695
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0006102isocitrate metabolic process ISS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with IDH3G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IDH3G

    7 HMDB Compounds for IDH3G    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Isocitric acid1-Hydroxy-1,2,3-propanetricarboxylate (see all 15)320-77-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--

    1 DrugBank Compound for IDH3G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--4292141 17139284 17016423 4380379 14189899



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IDH3G gene (2 alternative transcripts): 
    NM_004135.3  NM_174869.2  

    Unigene Cluster for IDH3G:

    Isocitrate dehydrogenase 3 (NAD+) gamma
    Hs.410197  [show with all ESTs]
    Unigene Representative Sequence: NM_174869
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370092(uc004fiq.3 uc004fit.1) ENST00000217901(uc004fip.3)
    ENST00000454076 ENST00000370093(uc004fiu.3) ENST00000427365 ENST00000444450
    ENST00000444338 ENST00000497043 ENST00000495356 ENST00000461215 ENST00000491235

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      QuantiFast Probe-based Assays in human, mouse, rat IDH3G

    Additional mRNA sequence: 

    BC000933.2 BC001902.1 U40272.1 U69268.1 U69269.1 Z68907.1 

    17 DOTS entries:

    DT.100854825  DT.97864675  DT.100854834  DT.454344  DT.100637890  DT.80100496  DT.100039177  DT.100854820 
    DT.121309385  DT.100854829  DT.91829470  DT.100039176  DT.100854828  DT.95105543  DT.100854836  DT.75151402 
    DT.95374710 

    Selected AceView cDNA sequences (see all 426):

    BM794116 BM998550 CD671511 BQ719081 BM704640 CR614068 CR616620 U69269 
    AA307345 AW005126 BQ008190 CR615747 BQ021293 BU730702 CR595975 BF445770 
    CR605410 BQ007099 BQ301885 CD364673 AW328239 BM970150 AA641973 CR590006 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:              -     -                             -                                                                                 
    SP2:                                                  -                                                                                 
    SP3:                                                  -                                                                                 
    SP4:                                                                                                              -                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for IDH3G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IDH3G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAATGAGA
    IDH3G Expression
    About this image


    IDH3G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IDH3G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IDH3G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410197
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDH3G: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDH3G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IDH3G gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Idh3g1 , 5 isocitrate dehydrogenase 3 (NAD+), gamma1, 5 87.7(n)1
    95.17(a)1
      X (37.41 cM)5
    159291  NM_008323.11  NP_032349.11 
     737789635 
    chicken
    (Gallus gallus)
    Aves IDH3G6
    isocitrate dehydrogenase 3 (NAD+) gamma
    78(a)
    1 ↔ 1
    AADN03021916.1(21-1175)
    lizard
    (Anolis carolinensis)
    Reptilia IDH3G6
    isocitrate dehydrogenase 3 (NAD+) gamma
    80(a)
    1 ↔ 1
    2(86478992-86499557)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD329569.12   -- 78.3(n)    CD329569.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa01b022 Transcribed sequence with weak similarity to protein more 76.69(n)    57052367 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50281 , 3 isocitrate dehydrogenase (NAD+)3
    CG50281
    52(a)
    (best of 2)3
    58.88(n)1
    53.59(a)1
      96E93
    431021  NM_001104453.21  NP_001097923.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F35G12.23
    idhg-11
    isocitrate dehydrogenase3
    idhg-11
    57(a)
    (best of 3)3
    56.89(n)1
    58.08(a)1
      III(4640817-4642267)3
    1755981  NM_065526.61  NP_497927.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IDH1(YNL037C)4 Subunit of mitochondrial NAD(+)-dependent isocitrate more   --   14(559002-557920) 855691  NP_014361.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IDH-III1 IDH-III 49.56(n)
    48.4(a)
      829717  NM_119730.2  NP_195290.1 
    rice
    (Oryza sativa)
    Liliopsida AK072524.12   -- 74.15(n)    AK072524.1 


    ENSEMBL Gene Tree for IDH3G (if available)
    TreeFam Gene Tree for IDH3G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IDH3G gene
    IDH3B2  
    3 SIMAP similar genes for IDH3G using alignment to 8 protein entries:     IDH3G_HUMAN (see all proteins):
    IDH3GL    IDH3B    IDH3A

    Find genes that share paralogs with IDH3G           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IDH3G
    PGOHUM00000242613


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IDH3G (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929006731,2
    C--153051756(+) TCAGTC/TCCTGG 2 -- int10--------
    rs1834907811,2
    C--153051841(+) GGCCAG/TCAGGG 4 M L mis10--------
    rs1488907091,2
    C--153051846(+) GCAGGA/GTGGCC 4 T I mis10--------
    rs1450248221,2
    C,F--153051851(+) GTGGCC/TGTGGG 4 T syn11Minor allele frequency- T:0.00NA 3888
    rs1131037091,2
    C--153051887(+) CTCTTG/TCCGGT 4 G syn10--------
    rs1116437961,2
    C--153051905(+) GTAGCC/TTGGGG 2 -- spa10--------
    rs20711221,2
    C,F,H--153051907(+) AGCCTG/AGGGAG 2 -- int119Minor allele frequency- A:0.48NS EA NA WA CSA 1983
    rs1884258251,2
    --153052062(+) CTTATG/TGGGAC 2 -- int10--------
    rs1115323461,2
    C,F--153052150(+) AACTAT/CTAAAT 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs2022280891,2
    C--153052225(+) AAGGCA/GGCAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for IDH3G (153051221 - 153059978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IDH3G:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IDH3G
    DNA2.0 Custom Variant and Variant Library Synthesis for IDH3G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300089    OMIM disorders: --

    1 disease for IDH3G:    
    About MalaCards
    periventricular heterotopia


    Find genes that share disorders with IDH3G           About GenesLikeMe


    Export disorders for IDH3G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IDH3G gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with IDH3G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PubMed id 9286695)1, 2, 3 Brenner V.... Platzer M. (Genomics 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1, 2 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    4. Identification and functional characterization of a novel, tissue- specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform. (PubMed id 10601238)1, 2 Kim Y.-O.... Huh T.-L. (J. Biol. Chem. 1999)
    5. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. (PubMed id 17432878)1 Bzymek K.P. and Colman R.F. (Biochemistry 2007)
    10. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (Cell Cycle 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3421 HGNC: 5386 AceView: IDH3G Ensembl:ENSG00000067829 euGenes: HUgn3421
    ECgene: IDH3G Kegg: 3421 H-InvDB: IDH3G

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IDH3G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IDH3G gene:
    Search GeneIP for patents involving IDH3G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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