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Aliases & Descriptions for IDH3G
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 1.1.1.41 3 H-IDHG 2 IDH-gamma 2 OTTHUMP00000025985 2
Descriptions Isocitric dehydrogenase 2 , 3 NAD (H)-specific isocitrate dehydrogenase gamma subunit 2 NAD(+)-specific ICDH 3 NAD+-specific ICDH 2 isocitrate dehydrogenase 3 (NAD+) gamma 2 isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit 2
Search outside databases for aliases for IDH3G genePrevious GC identifers: GC0XM147188 GC0XM149506 GC0XM150636 GC0XM151519 GC0XM152572
Summaries for IDH3G (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for IDH3G : Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electronacceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: threeNAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and twoNADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the otherpredominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allostericallyregulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramerthat is composed of two alpha subunits, one beta subunit, and one gamma subunit. The proteinencoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitratedehydrogenase. This gene is a candidate gene for periventricular heterotopia. Severalalternatively spliced transcript variants of this gene have been described, but only some of theirfull length natures have been determined. [provided by RefSeq] Gene Wiki entry for IDH3G
Genomic Location for IDH3G
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the IDH3G gene Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 IDH3G Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM152704:
(about GC identifiers )
Start:
152,704,415 bp from pter
End:
152,713,161 bp from pter
Size:
8,747 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011726.13 Proteins for IDH3G
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: IDH3G_HUMAN, P51553 (See
protein sequence )Recommended Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor Size : 393 amino acids; 42794 Da
Cofactor : Binds 1 magnesium or manganese ion per subunit (By similarity)
Subunit : Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (Bysimilarity)
Subcellular location : Mitochondrion
Secondary accessions : Q9BUU5
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004126.1 NP_777358.1 ENSEMBL proteins: ENSP00000217901 ENSP00000377366 ENSP00000359110 ENSP00000377363 ENSP00000359111 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: IDH3G 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for IDH3G: Assays for IDH3G:
Protein
Domains/ Families for IDH3G(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P51553 ProtoNet protein and cluster: P51553
1 Blocks protein family : IPB001804 Isocitrate/isopropylmalate dehydrogenase UniProtKB/Swiss-Prot: IDH3G_HUMAN, P51553 Similarity : Belongs to the isocitrate and isopropylmalate dehydrogenases family
Gene Function for IDH3G
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_174869 Applied Biosystems Silencer ® siRNAs for IDH3G Sigma-Aldrich siRNA for IDH3G Sigma-Aldrich shRNA for IDH3G Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004135                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004135                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004135  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004135 UniProtKB/Swiss-Prot: IDH3G_HUMAN, P51553 Catalytic activity : Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADHEnzyme regulation : Activated by increasing ADP/ATP ratios and by Ca(2+) (By similarity)Enzyme Number (IUBMB): EC 1.1.1.41
Genatlas biochemistry entry for IDH3G :isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in manytissues,catalyzing the third step of citric acid cycle,catalyzing the oxidative decarboxylation ofisocitrate into alpha-ketoglutarate 5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
):
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Pathways & Interactions for IDH3G
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for IDH3G (Your Favorite Gene powered by Ingenuity) 5/13 Interacting proteins for IDH3G (ENSP00000217901 3 ) via UniProtKB, MINT, and/or STRING (see all 13
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for IDH3G (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for IDH3G(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_174869 Sigma-Aldrich siRNA for IDH3G Sigma-Aldrich shRNA for IDH3G Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004135 NM_174869
REFSEQ mRNAs for IDH3G gene (2 alternative transcripts): NM_004135.2 NM_174869.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004135 NM_174869
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004135                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004135                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004135  
Additional cDNA sequence: AB209206.1 BC000933.2 BC001902.1 CR590006.1 CR595957.1 CR595975.1 CR599559.1 CR605410.1 CR606786.1 CR608068.1 CR612798.1 CR614068.1 CR615747.1 CR616395.1 CR616620.1 CR626830.1 U40272.1 U69268.1 U69269.1 Z68907.1
18 DOTS entries : DT.100854825 DT.97864675 DT.100854834 DT.454344 DT.100637890 DT.121309385 DT.91829470 DT.80100496 DT.100039177 DT.100854820 DT.100854829 DT.95105543 DT.100039176 DT.100854828 DT.100854836 DT.75151402 DT.95374710 DT.95142095
24/426 AceView cDNA sequences (see all 426
):AA641973 CR606786 BQ007099 BU153610 U69268 BM680116 BQ447581 AA307345 AW005126 BQ448682 BM970150 CD364673 BM013648 BQ021293 BM014973 BQ301885 U69269 BQ008190 AW328239 CR616395 BQ446140 BM794116 CR612798 BM704640
highest scoring ESTs for IDH3G :Z68907 AL526481 AL560789 BC000933 BC001902 BE047641 BE276963 BE300119 BE389822 BE391040
Unigene Cluster for IDH3G: Isocitrate dehydrogenase 3 (NAD+) gamma Hs.410197 [show with all ESTs ] Unigene Representative Sequence: AB209206 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G (see all 8
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d SP1 :     -   -           -                             SP2 :                 -                             SP3 :                 -                             SP4 :                                     -         SP5 :                                            
About this scheme ECgene alternative splicing isoforms for IDH3G 5 Ensembl transcripts including schematic representations : ENST00000217901
ENST00000393771
ENST00000370092
ENST00000393768
ENST00000370093
Expression for IDH3G
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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IDH3G expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for IDH3G 1 / 2 / 3
5 probe-sets matching IDH3G gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GACAATGAGASOURCE GeneReport for Unigene cluster: Hs.410197 Expression variation in blood from EXPOLDB for IDH3G
Orthologs for IDH3G
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for IDH3G gene from 5/18 species (see all 18
)
About this table Species with no ortholog for IDH3G ENSEMBL Gene Tree for IDH3G Paralogs for IDH3G (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for IDH3G gene IDH3B 2 IDH3A 2 Pseudogenes 2 related pseudogenes
SNPs/Variants for IDH3G (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for IDH3G (up to first 250kb)
Disorders & Mutations for IDH3G
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300089
Medical News for IDH3G (Possibly Related Articles in
Doctor's Guide )
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--
Publications for IDH3G (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for IDH3G gene (see all 16
): Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PubMed id 9286695) 2, 3, 4 Brenner V....Platzer M. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614) 3, 4 Simpson J.C.... Wiemann S. (2000) Identification and functional characterization of a novel, tissue- specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform. (PubMed id 10601238) 3, 4 Kim Y.-O.... Huh T.-L. (1999) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. (PubMed id 17432878) 3 Bzymek K.P. and Colman R.F. (2007) Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. (PubMed id 16737955) 3 Soundar S....Colman R.F. (2006) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 3 Wiemann S....Poustka A. (2004) Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. (PubMed id 14555658) 3 Soundar S....Colman R.F. (2003)
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Genome Databases showing IDH3G
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing IDH3G
(According to HUGE )
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Specialized Databases showing IDH3G (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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