Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IDH3G Gene

Aliases for IDH3G Gene

  • Isocitrate Dehydrogenase 3 (NAD(+)) Gamma 2 3
  • Isocitrate Dehydrogenase 3 (NAD+) Gamma 2 3 5
  • Isocitric Dehydrogenase Subunit Gamma 3 4
  • NAD(+)-Specific ICDH Subunit Gamma 3 4
  • EC 1.1.1.41 4 63
  • Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit 3
  • NAD (H)-Specific Isocitrate Dehydrogenase Gamma Subunit 3
  • Isocitrate Dehydrogenase 3 Gamma 3
  • NAD+-Specific ICDH 3
  • IDH-Gamma 3
  • EC 1.1.1 63
  • H-IDHG 3

External Ids for IDH3G Gene

Previous GeneCards Identifiers for IDH3G Gene

  • GC0XM147188
  • GC0XM149506
  • GC0XM150636
  • GC0XM151519
  • GC0XM152572
  • GC0XM152704
  • GC0XM153051
  • GC0XM141708

Summaries for IDH3G Gene

Entrez Gene Summary for IDH3G Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3G Gene

IDH3G (Isocitrate Dehydrogenase 3 (NAD(+)) Gamma) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Citrate cycle (TCA cycle). GO annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3B.

Gene Wiki entry for IDH3G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3G Gene

Genomics for IDH3G Gene

Regulatory Elements for IDH3G Gene

Enhancers for IDH3G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IDH3G on UCSC Golden Path with GeneCards custom track

Promoters for IDH3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IDH3G on UCSC Golden Path with GeneCards custom track

Genomic Location for IDH3G Gene

Chromosome:
X
Start:
153,785,766 bp from pter
End:
153,794,523 bp from pter
Size:
8,758 bases
Orientation:
Minus strand

Genomic View for IDH3G Gene

Genes around IDH3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3G Gene

Proteins for IDH3G Gene

  • Protein details for IDH3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51553-IDH3G_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Protein Accession:
    P51553
    Secondary Accessions:
    • E9PDD5
    • Q9BUU5

    Protein attributes for IDH3G Gene

    Size:
    393 amino acids
    Molecular mass:
    42794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

    Alternative splice isoforms for IDH3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3G Gene

Proteomics data for IDH3G Gene at MOPED

Post-translational modifications for IDH3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for IDH3G Gene

Suggested Antigen Peptide Sequences for IDH3G Gene

Graphical View of Domain Structure for InterPro Entry

P51553

UniProtKB/Swiss-Prot:

IDH3G_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3G: view

No data available for Gene Families for IDH3G Gene

Function for IDH3G Gene

Molecular function for IDH3G Gene

GENATLAS Biochemistry:
isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in many tissues,catalyzing the third step of citric acid cycle,catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate
UniProtKB/Swiss-Prot CatalyticActivity:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by increasing ADP/ATP ratios and by Ca(2+).

Enzyme Numbers (IUBMB) for IDH3G Gene

Gene Ontology (GO) - Molecular Function for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with IDH3G: view
genes like me logo Genes that share phenotypes with IDH3G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IDH3G

miRNA for IDH3G Gene

miRTarBase miRNAs that target IDH3G

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3G Gene

Localization for IDH3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3G Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDH3G Gene COMPARTMENTS Subcellular localization image for IDH3G gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IDH3G Gene

Pathways & Interactions for IDH3G Gene

genes like me logo Genes that share pathways with IDH3G: view

Gene Ontology (GO) - Biological Process for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006102 isocitrate metabolic process IEA,ISS --
GO:0045926 negative regulation of growth IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3G: view

No data available for SIGNOR curated interactions for IDH3G Gene

Drugs & Compounds for IDH3G Gene

(5) Drugs for IDH3G Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isocitric acid Experimental Pharma 0
NADH Nutra Target 0
Manganese Pharma 32
NAD Pharma Full agonist, Agonist 0
Magnesium Nutra 0

(3) Additional Compounds for IDH3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with IDH3G: view

Transcripts for IDH3G Gene

Unigene Clusters for IDH3G Gene

Isocitrate dehydrogenase 3 (NAD+) gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for IDH3G Gene

GeneLoc Exon Structure for
IDH3G
ECgene alternative splicing isoforms for
IDH3G

Expression for IDH3G Gene

mRNA expression in normal human tissues for IDH3G Gene

Protein differential expression in normal tissues from HIPED for IDH3G Gene

This gene is overexpressed in Brain (10.4), Heart (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IDH3G Gene



SOURCE GeneReport for Unigene cluster for IDH3G Gene Hs.410197

genes like me logo Genes that share expression patterns with IDH3G: view

Protein tissue co-expression partners for IDH3G Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IDH3G Gene

Orthologs for IDH3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IDH3G 35
  • 90.73 (n)
  • 96.17 (a)
IDH3G 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDH3G 35
  • 90.73 (n)
  • 96.43 (a)
IDH3G 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idh3g 35
  • 87.7 (n)
  • 95.17 (a)
Idh3g 16
Idh3g 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IDH3G 35
  • 91.21 (n)
  • 88.74 (a)
IDH3G 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Idh3g 35
  • 87.62 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia IDH3G 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3G 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDH3G 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDH3G 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3g 35
  • 71.69 (n)
  • 81.92 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa01b02 35
zgc:113076 35
  • 69.18 (n)
  • 75 (a)
idh3g 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5028 37
  • 52 (a)
CG6439 37
  • 51 (a)
CG5028 35
  • 58.88 (n)
  • 53.59 (a)
CG5028 36
  • 46 (a)
OneToMany
CG7755 36
  • 24 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002192 35
  • 60.32 (n)
  • 54.46 (a)
worm
(Caenorhabditis elegans)
Secernentea C30F12.7 37
  • 56 (a)
C37E2.1 37
  • 49 (a)
F35G12.2 37
  • 57 (a)
idhg-1 35
  • 56.89 (n)
  • 58.08 (a)
idhg-1 36
  • 51 (a)
OneToMany
idhg-2 36
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH1 36
  • 47 (a)
OneToMany
IDH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-III 35
  • 49.56 (n)
  • 48.4 (a)
soybean
(Glycine max)
eudicotyledons Gma.7096 35
barley
(Hordeum vulgare)
Liliopsida Hv.2555 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8404 36
  • 55 (a)
OneToOne
Species with no ortholog for IDH3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDH3G Gene

ENSEMBL:
Gene Tree for IDH3G (if available)
TreeFam:
Gene Tree for IDH3G (if available)

Paralogs for IDH3G Gene

Paralogs for IDH3G Gene

(3) SIMAP similar genes for IDH3G Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IDH3G Gene

genes like me logo Genes that share paralogs with IDH3G: view

Variants for IDH3G Gene

Sequence variations from dbSNP and Humsavar for IDH3G Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs17429 -- 153,790,717(+) GACCA(C/T)GTCTC intron-variant
rs17430 -- 153,790,856(+) CTGGC(-/AG)AGAGA intron-variant
rs17431 -- 153,791,077(+) CTTCC(A/G)CTCTT intron-variant
rs2071122 -- 153,786,452(+) AGCCT(A/G)GGGAG intron-variant
rs2071123 -- 153,787,194(+) CATCG(A/C)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDH3G Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Variation tolerance for IDH3G Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDH3G Gene

HapMap Linkage Disequilibrium report
IDH3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3G Gene

Disorders for IDH3G Gene

Relevant External Links for IDH3G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDH3G

No disorders were found for IDH3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3G Gene

Publications for IDH3G Gene

  1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PMID: 9286695) Brenner V. … Platzer M. (Genomics 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  5. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PMID: 23798571) Roy S.J. … Parent J.L. (Mol. Endocrinol. 2013) 3

Products for IDH3G Gene

Sources for IDH3G Gene

Content