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Aliases for IDH3G Gene

Aliases for IDH3G Gene

  • Isocitrate Dehydrogenase 3 (NAD(+)) Gamma 2 3 5
  • Isocitrate Dehydrogenase 3 (NAD+) Gamma 2 3
  • Isocitric Dehydrogenase Subunit Gamma 3 4
  • NAD(+)-Specific ICDH Subunit Gamma 3 4
  • EC 1.1.1.41 4 61
  • Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit 3
  • Isocitrate Dehydrogenase [NAD] Subunit Gamma, Mitochondrial 3
  • NAD (H)-Specific Isocitrate Dehydrogenase Gamma Subunit 3
  • Isocitrate Dehydrogenase 3 Gamma 3
  • NAD+-Specific ICDH 3
  • IDH-Gamma 3
  • EC 1.1.1 61
  • H-IDHG 3

External Ids for IDH3G Gene

Previous GeneCards Identifiers for IDH3G Gene

  • GC0XM147188
  • GC0XM149506
  • GC0XM150636
  • GC0XM151519
  • GC0XM152572
  • GC0XM152704
  • GC0XM153051
  • GC0XM141708

Summaries for IDH3G Gene

Entrez Gene Summary for IDH3G Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3G Gene

IDH3G (Isocitrate Dehydrogenase 3 (NAD(+)) Gamma) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). GO annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3B.

Gene Wiki entry for IDH3G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3G Gene

Genomics for IDH3G Gene

Regulatory Elements for IDH3G Gene

Enhancers for IDH3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF153844 0.6 ENCODE 13.7 -51.2 -51157 1.8 ZNF316 PBX2 MAFG EMSY MAFK SSR4 IDH3G SRPK3 PLXNB3 L1CAM ABCD1 BCAP31 FAM3A CYCSP45 GC0XM153869
GH0XF153854 0.5 ENCODE 13.5 -60.3 -60338 0.2 CTCF HLF L1CAM PDZD4 AVPR2 SSR4 IDH3G SRPK3 PLXNB3 ABCD1 BCAP31 CYCSP45
GH0XF153886 0.5 FANTOM5 ENCODE 13.2 -92.4 -92445 1.3 ZNF263 KLF1 MAZ ZIC2 GATA3 GATA2 ZBTB48 IKZF1 EZH2 EGR2 RENBP TMEM187 PDZD4 IDH3G SSR4 SRPK3 PLXNB3 ARHGAP4 NAA10 ABCD1
GH0XF153792 0.2 ENCODE 0.8 +0.1 145 3.3 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A GLI4 DMAP1 BRCA1 ETS1 PLXNB3 SRPK3 IDH3G SSR4
GH0XF153818 0.5 Ensembl ENCODE 0.3 -24.6 -24558 1.9 ZNF76 KLF17 ZIC2 HIC1 ZNF121 E2F1 GLIS2 ZBTB48 POLR2A PATZ1 PDZD4 SRPK3 IDH3G
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IDH3G on UCSC Golden Path with GeneCards custom track

Promoters for IDH3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000483120 -77 2801 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A GLI4 DMAP1 BRCA1 YY1

Genomic Location for IDH3G Gene

Chromosome:
X
Start:
153,785,766 bp from pter
End:
153,794,523 bp from pter
Size:
8,758 bases
Orientation:
Minus strand

Genomic View for IDH3G Gene

Genes around IDH3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3G Gene

Proteins for IDH3G Gene

  • Protein details for IDH3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51553-IDH3G_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Protein Accession:
    P51553
    Secondary Accessions:
    • E9PDD5
    • Q9BUU5

    Protein attributes for IDH3G Gene

    Size:
    393 amino acids
    Molecular mass:
    42794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

    Alternative splice isoforms for IDH3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3G Gene

Selected DME Specific Peptides for IDH3G Gene

P51553:
  • GGPGLVAGAN
  • RENTEGEYS
  • VMPNLYG
  • DGLFLQCC
  • TEGEYSSLEHE
  • KNIANPTATLLASCMMLDHLK
  • VMPNLYGNI
  • VTAVHKAN
  • VTAVHKANI
  • PGDGIGPE
  • DILIVRE
  • RTSLDLYANVIHCK
  • VHKANIM

Post-translational modifications for IDH3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for IDH3G Gene

Suggested Antigen Peptide Sequences for IDH3G Gene

Graphical View of Domain Structure for InterPro Entry

P51553

UniProtKB/Swiss-Prot:

IDH3G_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3G: view

No data available for Gene Families for IDH3G Gene

Function for IDH3G Gene

Molecular function for IDH3G Gene

GENATLAS Biochemistry:
isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in many tissues,catalyzing the third step of citric acid cycle,catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate
UniProtKB/Swiss-Prot CatalyticActivity:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by increasing ADP/ATP ratios and by Ca(2+).

Enzyme Numbers (IUBMB) for IDH3G Gene

Gene Ontology (GO) - Molecular Function for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004449 isocitrate dehydrogenase (NAD+) activity IEA,ISS --
GO:0005524 ATP binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with IDH3G: view
genes like me logo Genes that share phenotypes with IDH3G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IDH3G

miRNA for IDH3G Gene

miRTarBase miRNAs that target IDH3G

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3G Gene

Localization for IDH3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3G Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDH3G Gene COMPARTMENTS Subcellular localization image for IDH3G gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA,ISS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with IDH3G: view

Pathways & Interactions for IDH3G Gene

genes like me logo Genes that share pathways with IDH3G: view

Gene Ontology (GO) - Biological Process for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 9286695
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006102 isocitrate metabolic process ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3G: view

No data available for SIGNOR curated interactions for IDH3G Gene

Drugs & Compounds for IDH3G Gene

(6) Drugs for IDH3G Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Vet_approved Pharma 0
Manganese Approved Nutra 34
Isocitric acid Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for IDH3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with IDH3G: view

Transcripts for IDH3G Gene

Unigene Clusters for IDH3G Gene

Isocitrate dehydrogenase 3 (NAD+) gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for IDH3G Gene

GeneLoc Exon Structure for
IDH3G
ECgene alternative splicing isoforms for
IDH3G

Expression for IDH3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDH3G Gene

Protein differential expression in normal tissues from HIPED for IDH3G Gene

This gene is overexpressed in Brain (10.4), Heart (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IDH3G Gene



Protein tissue co-expression partners for IDH3G Gene

NURSA nuclear receptor signaling pathways regulating expression of IDH3G Gene:

IDH3G

SOURCE GeneReport for Unigene cluster for IDH3G Gene:

Hs.410197
genes like me logo Genes that share expression patterns with IDH3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IDH3G Gene

Orthologs for IDH3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDH3G 34 35
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia IDH3G 34 35
  • 90.73 (n)
dog
(Canis familiaris)
Mammalia IDH3G 34 35
  • 90.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3G 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idh3g 34 16 35
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Idh3g 34
  • 87.62 (n)
oppossum
(Monodelphis domestica)
Mammalia IDH3G 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDH3G 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDH3G 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3g 34
  • 71.69 (n)
zebrafish
(Danio rerio)
Actinopterygii idh3g 35
  • 70 (a)
OneToOne
zgc:113076 34
  • 69.18 (n)
wufa01b02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002192 34
  • 60.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5028 36 34 35
  • 58.88 (n)
CG6439 36
  • 51 (a)
CG7755 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35G12.2 36
  • 57 (a)
idhg-1 34 35
  • 56.89 (n)
C30F12.7 36
  • 56 (a)
idhg-2 35
  • 53 (a)
OneToMany
C37E2.1 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH1 35 37
  • 47 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-III 34
  • 49.56 (n)
soybean
(Glycine max)
eudicotyledons Gma.7096 34
barley
(Hordeum vulgare)
Liliopsida Hv.2555 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8404 35
  • 55 (a)
OneToOne
Species where no ortholog for IDH3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDH3G Gene

ENSEMBL:
Gene Tree for IDH3G (if available)
TreeFam:
Gene Tree for IDH3G (if available)

Paralogs for IDH3G Gene

Paralogs for IDH3G Gene

(3) SIMAP similar genes for IDH3G Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IDH3G Gene

genes like me logo Genes that share paralogs with IDH3G: view

Variants for IDH3G Gene

Sequence variations from dbSNP and Humsavar for IDH3G Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111252346 -- 153,791,203(+) CTAAC(C/T)CTGGT intron-variant
rs111532346 -- 153,786,695(+) AACTA(C/T)TAAAT intron-variant
rs111581005 -- 153,793,958(+) GAAGG(A/G)CTCCT intron-variant, upstream-variant-2KB
rs112083595 -- 153,790,764(+) ATTGC(A/G)GCCAC intron-variant
rs112653373 -- 153,788,240(+) ATGTT(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDH3G Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407

Variation tolerance for IDH3G Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDH3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDH3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3G Gene

Disorders for IDH3G Gene

Relevant External Links for IDH3G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDH3G

No disorders were found for IDH3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3G Gene

Publications for IDH3G Gene

  1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PMID: 9286695) Brenner V. … Platzer M. (Genomics 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4 64
  4. Identification and functional characterization of a novel, tissue- specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform. (PMID: 10601238) Kim Y.-O. … Huh T.-L. (J. Biol. Chem. 1999) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for IDH3G Gene

Sources for IDH3G Gene

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