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Aliases for IDH3G Gene

Aliases for IDH3G Gene

  • Isocitrate Dehydrogenase 3 (NAD(+)) Gamma 2 3 5
  • Isocitrate Dehydrogenase 3 (NAD+) Gamma 2 3
  • Isocitric Dehydrogenase Subunit Gamma 3 4
  • NAD(+)-Specific ICDH Subunit Gamma 3 4
  • Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit 3
  • Isocitrate Dehydrogenase [NAD] Subunit Gamma, Mitochondrial 3
  • NAD (H)-Specific Isocitrate Dehydrogenase Gamma Subunit 3
  • Isocitrate Dehydrogenase 3 Gamma 3
  • NAD+-Specific ICDH 3
  • EC 1.1.1.41 58
  • IDH-Gamma 3
  • EC 1.1.1 58
  • H-IDHG 3

External Ids for IDH3G Gene

Previous GeneCards Identifiers for IDH3G Gene

  • GC0XM147188
  • GC0XM149506
  • GC0XM150636
  • GC0XM151519
  • GC0XM152572
  • GC0XM152704
  • GC0XM153051
  • GC0XM141708

Summaries for IDH3G Gene

Entrez Gene Summary for IDH3G Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3G Gene

IDH3G (Isocitrate Dehydrogenase 3 (NAD(+)) Gamma) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). GO annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3B.

UniProtKB/Swiss-Prot for IDH3G Gene

  • Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Gene Wiki entry for IDH3G Gene

Additional gene information for IDH3G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3G Gene

Genomics for IDH3G Gene

Regulatory Elements for IDH3G Gene

Enhancers for IDH3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH153886 0.9 FANTOM5 ENCODE 13.2 -92.4 -92445 1 MAZ KLF1 GATA3 GATA2 ZBTB48 IKZF1 ZIC2 EZH2 EGR2 RENBP TMEM187 PDZD4 SSR4 IDH3G SRPK3 PLXNB3 ARHGAP4 NAA10 ABCD1
GH0XH153844 0.5 ENCODE 13.7 -51.2 -51157 1 ZNF316 MAFG EMSY MAFK IDH3G SSR4 SRPK3 PLXNB3 L1CAM ABCD1 BCAP31 FAM3A CYCSP45 GC0XM153869
GH0XH153854 0.4 ENCODE 13.5 -60.3 -60338 0 HLF L1CAM PDZD4 AVPR2 IDH3G SSR4 SRPK3 PLXNB3 BCAP31 ABCD1 CYCSP45
GH0XH153802 0.5 dbSUPER 5.6 -7.9 -7860 0 ZFHX2 POLR2A ZNF398 WT1 EGR2 IDH3G PDZD4
GH0XH153792 1.1 ENCODE 0.7 +0.1 145 3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 BRCA1 YY1 ETS1 SLC30A9 FLNA PLXNB3 EMD SRPK3 IDH3G SSR4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IDH3G on UCSC Golden Path with GeneCards custom track

Promoters for IDH3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249598 23 2601 PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 BRCA1 YY1 ETS1 SLC30A9

Genomic Location for IDH3G Gene

Chromosome:
X
Start:
153,785,766 bp from pter
End:
153,794,523 bp from pter
Size:
8,758 bases
Orientation:
Minus strand

Genomic View for IDH3G Gene

Genes around IDH3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3G Gene

Proteins for IDH3G Gene

  • Protein details for IDH3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51553-IDH3G_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Protein Accession:
    P51553
    Secondary Accessions:
    • E9PDD5
    • Q9BUU5

    Protein attributes for IDH3G Gene

    Size:
    393 amino acids
    Molecular mass:
    42794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.

    Three dimensional structures from OCA and Proteopedia for IDH3G Gene

    Alternative splice isoforms for IDH3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3G Gene

Selected DME Specific Peptides for IDH3G Gene

P51553:
  • GGPGLVAGAN
  • RENTEGEYS
  • VMPNLYG
  • DGLFLQCC
  • TEGEYSSLEHE
  • KNIANPTATLLASCMMLDHLK
  • VMPNLYGNI
  • VTAVHKAN
  • VTAVHKANI
  • PGDGIGPE
  • DILIVRE
  • RTSLDLYANVIHCK
  • VHKANIM

Post-translational modifications for IDH3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for IDH3G Gene

Gene Families for IDH3G Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IDH3G Gene

Graphical View of Domain Structure for InterPro Entry

P51553

UniProtKB/Swiss-Prot:

IDH3G_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3G: view

Function for IDH3G Gene

Molecular function for IDH3G Gene

GENATLAS Biochemistry:
isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in many tissues,catalyzing the third step of citric acid cycle,catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate
UniProtKB/Swiss-Prot EnzymeRegulation:
The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
UniProtKB/Swiss-Prot Function:
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Enzyme Numbers (IUBMB) for IDH3G Gene

Gene Ontology (GO) - Molecular Function for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA,IEA 28098230
GO:0004449 isocitrate dehydrogenase (NAD+) activity IEA,ISS --
GO:0005524 ATP binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with IDH3G: view
genes like me logo Genes that share phenotypes with IDH3G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IDH3G

CRISPR Products

miRNA for IDH3G Gene

miRTarBase miRNAs that target IDH3G

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IDH3G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3G Gene

Localization for IDH3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3G Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDH3G gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA,ISS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with IDH3G: view

Pathways & Interactions for IDH3G Gene

genes like me logo Genes that share pathways with IDH3G: view

Gene Ontology (GO) - Biological Process for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 9286695
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006102 isocitrate metabolic process ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3G: view

No data available for SIGNOR curated interactions for IDH3G Gene

Drugs & Compounds for IDH3G Gene

(6) Drugs for IDH3G Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 35
Carbon dioxide Approved, Vet_approved Pharma 0
Isocitric acid Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for IDH3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with IDH3G: view

Transcripts for IDH3G Gene

Unigene Clusters for IDH3G Gene

Isocitrate dehydrogenase 3 (NAD+) gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IDH3G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for IDH3G Gene

GeneLoc Exon Structure for
IDH3G
ECgene alternative splicing isoforms for
IDH3G

Expression for IDH3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IDH3G Gene

Protein differential expression in normal tissues from HIPED for IDH3G Gene

This gene is overexpressed in Brain (10.4), Heart (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IDH3G Gene



Protein tissue co-expression partners for IDH3G Gene

NURSA nuclear receptor signaling pathways regulating expression of IDH3G Gene:

IDH3G

SOURCE GeneReport for Unigene cluster for IDH3G Gene:

Hs.410197

Evidence on tissue expression from TISSUES for IDH3G Gene

  • Nervous system(4.8)
  • Heart(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with IDH3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3G Gene

Orthologs for IDH3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDH3G 33 34
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia IDH3G 33 34
  • 90.73 (n)
dog
(Canis familiaris)
Mammalia IDH3G 33 34
  • 90.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3G 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idh3g 33 16 34
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Idh3g 33
  • 87.62 (n)
oppossum
(Monodelphis domestica)
Mammalia IDH3G 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDH3G 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDH3G 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3g 33
  • 71.69 (n)
zebrafish
(Danio rerio)
Actinopterygii idh3g 34
  • 70 (a)
OneToOne
zgc:113076 33
  • 69.18 (n)
wufa01b02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002192 33
  • 60.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5028 35 33 34
  • 58.88 (n)
CG6439 35
  • 51 (a)
CG7755 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35G12.2 35
  • 57 (a)
idhg-1 33 34
  • 56.89 (n)
C30F12.7 35
  • 56 (a)
idhg-2 34
  • 53 (a)
OneToMany
C37E2.1 35
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH1 34 36
  • 47 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-III 33
  • 49.56 (n)
soybean
(Glycine max)
eudicotyledons Gma.7096 33
barley
(Hordeum vulgare)
Liliopsida Hv.2555 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8404 34
  • 55 (a)
OneToOne
Species where no ortholog for IDH3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDH3G Gene

ENSEMBL:
Gene Tree for IDH3G (if available)
TreeFam:
Gene Tree for IDH3G (if available)

Paralogs for IDH3G Gene

Paralogs for IDH3G Gene

(3) SIMAP similar genes for IDH3G Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IDH3G Gene

genes like me logo Genes that share paralogs with IDH3G: view

Variants for IDH3G Gene

Sequence variations from dbSNP and Humsavar for IDH3G Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000061564 -- 153,786,012(+) GCCCT(A/G)CCACC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000114958 -- 153,785,760(+) CCCAC(A/G)CCAAG downstream-variant-500B
rs1001972850 -- 153,790,962(+) GTGCA(A/G)CATGG intron-variant
rs1002300712 -- 153,791,421(+) CGAAA(A/G)CAAAT intron-variant
rs1002542494 -- 153,796,209(+) AAAGC(C/T)GGCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IDH3G Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407

Variation tolerance for IDH3G Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDH3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDH3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3G Gene

Disorders for IDH3G Gene

Relevant External Links for IDH3G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDH3G

No disorders were found for IDH3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3G Gene

Publications for IDH3G Gene

  1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PMID: 9286695) Brenner V … Platzer M (Genomics 1997) 2 3 4 60
  2. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4 60
  5. Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform. (PMID: 10601238) Kim YO … Huh TL (The Journal of biological chemistry 1999) 3 4 60

Products for IDH3G Gene

Sources for IDH3G Gene

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