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Aliases for IDH3A Gene

Aliases for IDH3A Gene

  • Isocitrate Dehydrogenase 3 (NAD(+)) Alpha 2 3 5
  • EC 1.1.1.41 4 58
  • Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial 2
  • NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2
  • Isocitrate Dehydrogenase (NAD+) Alpha Chain 2
  • Isocitrate Dehydrogenase 3 (NAD+) Alpha 2
  • Isocitric Dehydrogenase Subunit Alpha 4
  • NAD(+)-Specific ICDH Subunit Alpha 4
  • Isocitric Dehydrogenase 2
  • NAD+-Specific ICDH 2
  • H-IDH Alpha 2
  • EC 1.1.1 58

External Ids for IDH3A Gene

Previous GeneCards Identifiers for IDH3A Gene

  • GC15P074520
  • GC15P071531
  • GC15P076017
  • GC15P076157
  • GC15P076228
  • GC15P078441
  • GC15P055199
  • GC15P078423

Summaries for IDH3A Gene

Entrez Gene Summary for IDH3A Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3A Gene

IDH3A (Isocitrate Dehydrogenase 3 (NAD(+)) Alpha) is a Protein Coding gene. Among its related pathways are Citrate cycle (TCA cycle) and Metabolism. GO annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.

UniProtKB/Swiss-Prot for IDH3A Gene

  • Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Gene Wiki entry for IDH3A Gene

Additional gene information for IDH3A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3A Gene

Genomics for IDH3A Gene

Regulatory Elements for IDH3A Gene

Enhancers for IDH3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H078146 1.3 ENCODE dbSUPER 17.6 +17.1 17138 5 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 FOS SP3 SP5 MXD4 IDH3A SH2D7 TBC1D2B ENSG00000199633 CIB2 ENSG00000260988 GC15P078155
GH15H078166 1.3 Ensembl ENCODE dbSUPER 17.5 +39.2 39218 8 PKNOX1 TBL1XR1 BATF ZNF766 ATF7 RUNX3 IKZF2 CREM JUNB ELF1 CIB2 ENSG00000259562 IDH3A ENSG00000259322 SH2D7 TBC1D2B ENSG00000199633 IREB2 GC15P078155 PIR56006
GH15H078087 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.7 -43.2 -43239 1 SOX13 FOXA2 RELA ZNF7 YY1 FOSL1 EED HNF4G NFE2 NR2F6 LOC645752 IDH3A DNAJA4 IREB2 GC15M078092 ENSG00000199633 SH2D7
GH15H078156 0.6 dbSUPER 15.4 +25.7 25663 1 JUND PRDM6 GLIS1 CEBPB EP300 PRDM1 CIB2 IDH3A ENSG00000199633 SH2D7 TBC1D2B GC15P078155 PIR56006
GH15H078081 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -48.4 -48398 3 GATAD2A ZNF3 CEBPG FOSL1 POLR2A CEBPA IKZF1 SCRT2 RCOR2 HNF4A LOC645752 TBC1D2B IDH3A DNAJA4 IREB2 ENSG00000199633 SH2D7 GC15M078092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IDH3A on UCSC Golden Path with GeneCards custom track

Promoters for IDH3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079700 2 1401 HDGF PKNOX1 ATF1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for IDH3A Gene

Chromosome:
15
Start:
78,131,498 bp from pter
End:
78,171,949 bp from pter
Size:
40,452 bases
Orientation:
Plus strand

Genomic View for IDH3A Gene

Genes around IDH3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3A Gene

Proteins for IDH3A Gene

  • Protein details for IDH3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50213-IDH3A_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Protein Accession:
    P50213
    Secondary Accessions:
    • D3DW83
    • Q9H3X0

    Protein attributes for IDH3A Gene

    Size:
    366 amino acids
    Molecular mass:
    39592 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.

    Three dimensional structures from OCA and Proteopedia for IDH3A Gene

    Alternative splice isoforms for IDH3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3A Gene

Selected DME Specific Peptides for IDH3A Gene

P50213:
  • SKVSRLLGAFHN
  • RENTEGEYS
  • ANPTALLLS
  • APDIAGKD
  • GDGIGPEI
  • KCSDFTEEICR
  • ACFATIKDGKSLTKDLGGN
  • LLSAVMMLR
  • ANVRPCVSI
  • VMPNLYG
  • KFNEMYLDTVCLN
  • AGLIGGLG
  • VTAVHKAN
  • VTAVHKANI
  • PGDGIGPE
  • VHKANIM
  • GVVQSIKLIT

Post-translational modifications for IDH3A Gene

  • Ubiquitination at isoforms=58, posLast=7777, and posLast=100100
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for IDH3A

Domains & Families for IDH3A Gene

Gene Families for IDH3A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P50213

UniProtKB/Swiss-Prot:

IDH3A_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3A: view

Function for IDH3A Gene

Molecular function for IDH3A Gene

GENATLAS Biochemistry:
isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric acid cycle
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=20.0 umol/min/mg enzyme with isocitrate as substrate (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=10.9 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=7.29 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=20.7 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=10.0 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=22.1 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=9.42 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=21.3 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.9 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=13.1 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=17.7 umol/min/mg enzyme with isocitrate as substrate in the presence of ATP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=6.62 umol/min/mg enzyme with isocitrate as substrate in the presence ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=17.6 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=8.94 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Note=kcat is 26.7 sec(-1) for the heterotetramer with isocitrate as substrate. kcat is 14.6 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate. kcat is 9.72 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate. kcat is 23.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ATP. kcat is 11.9 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ATP. kcat is 28.4 sec(- 1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ADP. kcat is 15.8 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate in the presence of citrate and ADP. kcat is 17.6 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ADP. {ECO:0000269 PubMed:28139779};
UniProtKB/Swiss-Prot CatalyticActivity:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Enzyme Numbers (IUBMB) for IDH3A Gene

Phenotypes From GWAS Catalog for IDH3A Gene

Gene Ontology (GO) - Molecular Function for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 28098230
GO:0004449 isocitrate dehydrogenase (NAD+) activity IDA 28098230
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDH3A: view
genes like me logo Genes that share phenotypes with IDH3A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IDH3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3A Gene

Localization for IDH3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDH3A gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with IDH3A: view

Pathways & Interactions for IDH3A Gene

genes like me logo Genes that share pathways with IDH3A: view

Gene Ontology (GO) - Biological Process for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 8833160
GO:0006099 tricarboxylic acid cycle TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3A: view

No data available for SIGNOR curated interactions for IDH3A Gene

Drugs & Compounds for IDH3A Gene

(7) Drugs for IDH3A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 35
Copper Approved Pharma Target 188
Carbon dioxide Approved, Vet_approved Pharma 0
Isocitric acid Experimental Pharma 0
NADH Nutra Target 0

(2) Additional Compounds for IDH3A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with IDH3A: view

Transcripts for IDH3A Gene

Unigene Clusters for IDH3A Gene

Isocitrate dehydrogenase 3 (NAD+) alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IDH3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -
SP20:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for IDH3A Gene

GeneLoc Exon Structure for
IDH3A
ECgene alternative splicing isoforms for
IDH3A

Expression for IDH3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IDH3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDH3A Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for IDH3A Gene

This gene is overexpressed in Brain (8.6) and Nasal epithelium (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IDH3A Gene



Protein tissue co-expression partners for IDH3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IDH3A Gene:

IDH3A

SOURCE GeneReport for Unigene cluster for IDH3A Gene:

Hs.591110

Evidence on tissue expression from TISSUES for IDH3A Gene

  • Nervous system(5)
  • Heart(4.5)
  • Muscle(2.7)
  • Intestine(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with IDH3A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3A Gene

Orthologs for IDH3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDH3A 33 34
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia IDH3A 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3A 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IDH3A 33 34
  • 92.53 (n)
dog
(Canis familiaris)
Mammalia IDH3A 33 34
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Idh3a 33 16 34
  • 89.34 (n)
rat
(Rattus norvegicus)
Mammalia Idh3a 33
  • 88.98 (n)
chicken
(Gallus gallus)
Aves IDH3A 33 34
  • 80.9 (n)
lizard
(Anolis carolinensis)
Reptilia IDH3A 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3a 33
  • 76.5 (n)
MGC76128 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15952 33
zebrafish
(Danio rerio)
Actinopterygii idh3a 33 34
  • 75.78 (n)
zgc56380 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9912 33
fruit fly
(Drosophila melanogaster)
Insecta CG12233 35
  • 71 (a)
l(1)G0156 33 34
  • 64.6 (n)
CG3483 35 34
  • 39 (a)
CG32026 34
  • 30 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002728 33
  • 63.81 (n)
worm
(Caenorhabditis elegans)
Secernentea F43G9.1 35
  • 65 (a)
idha-1 33 34
  • 63.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03125g 33
  • 55.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH2 33 34 36
  • 54.48 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR137C 33
  • 53.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-V 33
  • 58.24 (n)
soybean
(Glycine max)
eudicotyledons Gma.7251 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6781 33
rice
(Oryza sativa)
Liliopsida Os01g0276100 33
  • 58.91 (n)
Os.207 33
barley
(Hordeum vulgare)
Liliopsida Hv.620 33
wheat
(Triticum aestivum)
Liliopsida Ta.24979 33
corn
(Zea mays)
Liliopsida Zm.3035 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07697 33
  • 58.28 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes idh2 33
  • 58.23 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8758 33
Species where no ortholog for IDH3A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IDH3A Gene

ENSEMBL:
Gene Tree for IDH3A (if available)
TreeFam:
Gene Tree for IDH3A (if available)

Paralogs for IDH3A Gene

No data available for Paralogs for IDH3A Gene

Variants for IDH3A Gene

Sequence variations from dbSNP and Humsavar for IDH3A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000028333 -- 78,164,828(+) ATGCT(C/G/T)GAGGC intron-variant
rs1000370566 -- 78,158,216(+) GAATG(A/G)AATGT intron-variant
rs1000667107 -- 78,157,887(+) TGAAC(G/T)CTGGG intron-variant
rs1000996110 -- 78,157,457(+) CATCT(C/G)ATAAA intron-variant
rs1001039260 -- 78,162,639(+) CTCCC(A/G)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDH3A Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259

Variation tolerance for IDH3A Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IDH3A Gene

Human Gene Mutation Database (HGMD)
IDH3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDH3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3A Gene

Disorders for IDH3A Gene

Relevant External Links for IDH3A

Genetic Association Database (GAD)
IDH3A
Human Genome Epidemiology (HuGE) Navigator
IDH3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IDH3A

No disorders were found for IDH3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3A Gene

Publications for IDH3A Gene

  1. Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PMID: 8833160) Huh TL … Inazawa J (Genomics 1996) 2 3 22 60
  2. Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PMID: 7755589) Kim YO … Huh TL (The Biochemical journal 1995) 3 4 22 60
  3. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

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