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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IDH3A Gene

protein-coding   GIFtS: 64
GCID: GC15P078423

Isocitrate Dehydrogenase 3 (NAD+) Alpha

  Search for IDH3A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Isocitrate Dehydrogenase 3 (NAD+) Alpha1 2     EC 1.1.1.413 8
H-IDH Alpha1 2     Isocitrate Dehydrogenase [NAD] Subunit Alpha1
Isocitrate Dehydrogenase (NAD+) Alpha Chain1 2     Isocitric Dehydrogenase1
NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit1 2     mitochondrial1
NAD+-Specific ICDH1 2     Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial2
Isocitric Dehydrogenase Subunit Alpha2 3     EC 1.1.18
NAD(+)-Specific ICDH Subunit Alpha2 3     

External Ids:    HGNC: 53841   Entrez Gene: 34192   Ensembl: ENSG000001664117   OMIM: 6011495   UniProtKB: P502133   

Export aliases for IDH3A gene to outside databases

Previous GC identifers: GC15P074520 GC15P071531 GC15P076017 GC15P076157 GC15P076228 GC15P078441 GC15P055199


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IDH3A Gene:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes
belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which
localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is
mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the
allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer
that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene
is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. (provided by RefSeq, Jul 2008)

GeneCards Summary for IDH3A Gene: 
IDH3A (isocitrate dehydrogenase 3 (NAD+) alpha) is a protein-coding gene. Among its related super-pathways are Citric acid cycle (TCA cycle) and Metabolic pathways. GO annotations related to this gene include isocitrate dehydrogenase (NAD+) activity and magnesium ion binding.

Gene Wiki entry for IDH3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IDH3A gene promoter:
         NF-1   NF-1/L   STAT1   GCNF   STAT1beta   AP-2gamma   YY1   STAT1alpha   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIDH3A promoter sequence
   Search SABiosciences Chromatin IP Primers for IDH3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IDH3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1-q25.2   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1-q25.2

IDH3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDH3A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078423:  view genomic region     (about GC identifiers)

Start:
78,423,840 bp from pter      End:
78,464,291 bp from pter
Size:
40,452 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IDH3A_HUMAN, P50213 (See protein sequence)
Recommended Name: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor  
Size: 366 amino acids; 39592 Da
Cofactor: Binds 1 magnesium or manganese ion per subunit (By similarity)
Subunit: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: D3DW83 Q9H3X0
Alternative splicing: 2 isoforms:  P50213-1   P50213-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IDH3A: NX_P50213

Explore proteomics data for IDH3A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50213

  • 4/17 DME Specific Peptides for IDH3A (P50213) (see all 17)
     VHKANIM  VMPNLYG  APDIAGKD  GDGIGPEI 

    IDH3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IDH3A Protein Expression
    REFSEQ proteins: NP_005521.1  
    ENSEMBL proteins: 
     ENSP00000299518   ENSP00000452620   ENSP00000453084   ENSP00000453033   ENSP00000453480  
     ENSP00000453747   ENSP00000452754   ENSP00000453192   ENSP00000453903   ENSP00000453438  
     ENSP00000453222   ENSP00000453992   ENSP00000453338   ENSP00000453989   ENSP00000453008  
     ENSP00000453795   ENSP00000453459   ENSP00000387506  
    Reactome Protein details: P50213
    Human Recombinant Protein Products for IDH3A: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--

    IDH3A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR004434 Isocitrate_DH_NAD
     IPR001804 Isocitrate/isopropylmalate_DH
     IPR019818 IsoCit/isopropylmalate_DH_CS
     IPR024084 IsoPropMal-DH-like_dom

    Graphical View of Domain Structure for InterPro Entry P50213

    ProtoNet protein and cluster: P50213

    1 Blocks protein domain: IPB001804 Isocitrate/isopropylmalate dehydrogenase

    UniProtKB/Swiss-Prot: IDH3A_HUMAN, P50213
    Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family


    IDH3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDH3A_HUMAN, P50213
    Catalytic activity: Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH

         Genatlas biochemistry entry for IDH3A:
    isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric
    acid cycle

         Enzyme Numbers (IUBMB): EC 1.1.1.411 2 EC 1.1.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004449isocitrate dehydrogenase (NAD+) activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding IEA--
         
    IDH3A for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidIDH3A 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IDH3A About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citric acid cycle (TCA cycle)0.89
    TCA cycle0.84
    TCA Cycle0.89
    Citrate cycle (TCA cycle)0.58
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    5Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for IDH3A
        TCA Cycle
    TCA cycle
    Conversion of glucose to acetyl CoA and entry into the TCA cycle


    4        Reactome Pathways for IDH3A
        Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    Citric acid cycle (TCA cycle)
    The citric acid (TCA) cycle and respiratory electron transport


    5         Kegg Pathways  (Kegg details for IDH3A):
        Citrate cycle (TCA cycle)
    Metabolic pathways
    Carbon metabolism
    2-Oxocarboxylic acid metabolism
    Biosynthesis of amino acids


    IDH3A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IDH3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/178 Interacting proteins for IDH3A (P502132, 3 ENSP000002995184) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48179 I2D: score=2 
    IDH3BO438373, ENSP000003702234I2D: score=8 STRING: ENSP00000370223
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    ENSG00000258947Q135093I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS8833160
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    IDH3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for IDH3A

    7 HMDB Compounds for IDH3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Isocitric acid1-Hydroxy-1,2,3-propanetricarboxylate (see all 15)320-77-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--

    1 DrugBank Compound for IDH3A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--4292141 17139284 17016423 13152105 4380379

    Search CenterWatch for drugs/clinical trials and news about IDH3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IDH3A gene: 
    NM_005530.2  

    Unigene Cluster for IDH3A:

    Isocitrate dehydrogenase 3 (NAD+) alpha
    Hs.591110  [show with all ESTs]
    Unigene Representative Sequence: AK123316
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000558605 ENST00000299518(uc002bdd.3 uc010umt.2 uc010umu.2 uc002bdf.3 uc010umv.2 uc021srf.1)
    ENST00000558933 ENST00000558554 ENST00000560667 ENST00000557826 ENST00000561279
    ENST00000559186 ENST00000560396 ENST00000560770 ENST00000559865 ENST00000559881
    ENST00000558509 ENST00000559889 ENST00000559803 ENST00000559205 ENST00000560414
    ENST00000559106
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    Additional mRNA sequence: 

    AK093531.1 AK096721.1 AK123316.1 AK222973.1 AK296002.1 AK299970.1 AK315963.1 AK316051.1 
    AL110096.1 AL442090.1 BC021967.2 BC036227.1 CR749548.1 U07681.1 

    24/26 DOTS entries (see all 26):

    DT.86855063  DT.99945419  DT.100824942  DT.100824943  DT.100824944  DT.95258957  DT.100824933  DT.92443593 
    DT.91830964  DT.100824945  DT.100027192  DT.95197969  DT.95363838  DT.121032158  DT.121032190  DT.121032180 
    DT.430952  DT.100027191  DT.121032125  DT.121032155  DT.121032166  DT.100714103  DT.100824938  DT.101983174 

    24/340 AceView cDNA sequences (see all 340):

    AI802723 BP352536 CB159510 CB115049 AA417949 BG430808 AI095654 BE550193 
    BQ016120 CA430498 BQ773356 BP363836 BI764481 AI424108 AI567272 CB266030 
    BM838562 BM719480 BF111986 BQ636491 C04795 AA947090 BX415772 BM839898 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for IDH3A (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^
    SP1:                    -     -                 -     -     -                                                     -                 -     -                     
    SP2:                                                  -     -                                                     -                 -     -                     
    SP3:                                                                                                              -                 -     -                     
    SP4:                                            -     -     -                 -                                   -                 -     -                     
    SP5:                                            -     -     -     -                                               -                 -     -                     

    ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for IDH3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IDH3A expression in normal human tissues (normalized intensities)      IDH3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCTTTG
    IDH3A Expression
    About this image


    IDH3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart/atrium   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon

    See IDH3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IDH3A

    SOURCE GeneReport for Unigene cluster: Hs.591110
        SABiosciences Expression via Pathway-Focused PCR Arrays including IDH3A: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IDH3A gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Idh3a1 , 5 isocitrate dehydrogenase 3 (NAD+) alpha1, 5 89.34(n)1
    97.54(a)1
      9 (29.70 cM)5
    678341  NM_029573.21  NP_083849.11 
     545865115 
    chicken
    (Gallus gallus)
    Aves IDH3A1 isocitrate dehydrogenase 3 (NAD+) alpha 80.9(n)
    91.18(a)
      415362  NM_001005808.1  NP_001005808.1 
    lizard
    (Anolis carolinensis)
    Reptilia IDH3A6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343486.1(121133-135305)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159522 Xenopus laevis transcribed sequence with moderate similarity more 78.32(n)    BU913373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563802 similar to isocitrate dehydrogenase 3 (NAD+) alpha 77.55(n)   393926  BC049011.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122333
    l(1)G01561
    isocitrate dehydrogenase (NAD+)3
    lethal (1) G01561
    71(a)
    (best of 2)3
    64.6(n)1
    71.3(a)1
      18C83
    329401  NM_167657.21  NP_728257.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F43G9.13
    idha-11
    isocitrate dehydrogenase3
    Protein IDHA-11
    65(a)3
    63.08(n)1
    70.54(a)1
      I(8614990-8616683)3
    1726551  NM_059929.21  NP_492330.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IDH2(YOR136W)4
    IDH21
    Subunit of mitochondrial NAD(+)-dependent isocitrate more4
    Idh2p1
    54.48(n)1
    56.5(a)1
      15(580250-581359)4
    8543031, 4  NP_014779.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IDH-VI1 Isocitrate dehydrogenase [NAD] catalytic subunit 6 60.1(n)
    57.23(a)
      820139  NM_180218.1  NP_850549.1 
    rice
    (Oryza sativa)
    Liliopsida Os.2072 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.77(n)    AK059596.1 


    ENSEMBL Gene Tree for IDH3A (if available)
    TreeFam Gene Tree for IDH3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IDH3A gene
    3 SIMAP similar genes for IDH3A using alignment to 14 protein entries:     IDH3A_HUMAN (see all proteins):
    DKFZp686A08194    IDH3G    IDH3B

    IDH3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/449 SNPs in IDH3A are shown (see all 449)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44352311,2
    C,H--78439745(+) ATCTTC/TTCAAT 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs586568281,2
    C,F--78439829(+) AGAGGG/CGGACA 1 -- us2k12Minor allele frequency- C:0.25WA 120
    rs1837534881,2
    --78439840(+) CATTCA/GTGGGT 1 -- us2k10--------
    rs1879392061,2
    --78439963(+) TGGCAC/TGACCA 1 -- us2k10--------
    rs1923665721,2
    --78440134(+) AGAGCC/TGGGGC 1 -- us2k10--------
    rs1846270691,2
    --78440139(+) CGGGGC/TGAGCC 1 -- us2k10--------
    rs1898633441,2
    --78440147(+) GCCCTA/GGTCAG 1 -- us2k10--------
    rs796567891,2
    C,F--78440224(+) TGGTCT/CGGCCC 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1431148911,2
    C--78440229(+) TGGCCC/TGAAGG 1 -- us2k10--------
    rs1512285251,2
    --78440256(+) TGGGGA/GTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IDH3A (78423840 - 78464291 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IDH3A: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IDH3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IDH3A for disorders           About MalaCards
    OMIM gene information: 601149    OMIM disorders: --


    IDH3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): IDH3A
    Human Genome Epidemiology (HuGE) Navigator: IDH3A (2 documents)

    Export disorders for IDH3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IDH3A gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with IDH3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PubMed id 7755589)1, 2, 9 Kim Y.O.... Huh T.L. (1995)
    2. Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PubMed id 8833160)1, 3, 9 Huh T.L....Inazawa J. (1996)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3419 HGNC: 5384 AceView: IDH3A Ensembl:ENSG00000166411 euGenes: HUgn3419
    ECgene: IDH3A Kegg: 3419 H-InvDB: IDH3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IDH3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IDH3A gene:
    Search GeneIP for patents involving IDH3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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