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IDH2 Gene

protein-coding GIFtS: 62

GC15M088428

isocitrate dehydrogenase 2 (NADP+), mitochondrial
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.1.1.42 ^³
ICD-M ^², ³
IDH ^², ³
IDHM ^²
IDP ^², ³
IDPM ^²
mNADP-IDH ^²

Descriptions
NADP(+)-specific ICDH ^³
NADP+-specific ICDH ^²
Oxalosuccinate decarboxylase ^², ³
isocitrate dehydrogenase 2 (NADP+), mitochondrial ^²
isocitrate dehydrogenase, mitochondrial ^²

External Ids
HGNC: 5383¹
Entrez Gene: 3418²
UniProtKB: P48735³
Ensembl: ENSG00000182054⁷

Search outside databases for aliases for IDH2 gene

Previous GC identifers: GC15M087031 GC15M084133 GC15M088213 GC15M088356

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDH2:

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron

acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three

NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two

NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other

predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by

this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a

role in intermediary metabolism and energy production. This protein may tightly associate or

interact with the pyruvate dehydrogenase complex. [provided by RefSeq]

UniProtKB/Swiss-Prot: IDHP_HUMAN, P48735

Function: Plays a role in intermediary metabolism and energy production. It may tightly associate

or interact with the pyruvate dehydrogenase complex

Gene Wiki entry for IDH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IDH2 gene

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q21-qter

IDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M088428: (about GC identifiers)

Start:	88,428,214 bp from pter
End:	88,446,712 bp from pter
Size:	18,499 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010274.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IDHP_HUMAN, P48735 (See protein sequence)

Recommended Name: Isocitrate dehydrogenase [NADP], mitochondrial precursor

Size: 452 amino acids; 50909 Da

Cofactor: Binds 1 magnesium or manganese ion per subunit (By similarity)

Subunit: Homodimer

Subcellular location: Mitochondrion

Secondary accessions: Q96GT3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002159.2

ENSEMBL proteins:

ENSP00000331897

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IDH2)
	Human Recombinant Proteins from Abnova (IDH2)

OriGene Purified Recombinant Human Protein: IDH2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

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Antibodies for IDH2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IDH2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IDH2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IDH2)
	Novus Biologicals Antibodies for IDH2

Assays for IDH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P48735

ProtoNet protein and cluster: P48735

1 Blocks protein family: IPB001804 Isocitrate/isopropylmalate dehydrogenase

UniProtKB/Swiss-Prot: IDHP_HUMAN, P48735

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDH2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002168

Applied Biosystems Silencer® siRNAs for IDH2

Sigma-Aldrich siRNA for IDH2

Sigma-Aldrich shRNA for IDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IDH2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002168
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002168
untagged cDNA clone in CMV expression vector: NM_002168

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002168

UniProtKB/Swiss-Prot: IDHP_HUMAN, P48735

Function: Plays a role in intermediary metabolism and energy production. It may tightly associate

or interact with the pyruvate dehydrogenase complex

Catalytic activity: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Catalytic activity: Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Enzyme Number (IUBMB): EC 1.1.1.42

Genatlas biochemistry entry for IDH2:

isocitrate dehydrogenase 2,mitochrondrial matrix,NADPH dependent,46.5 kDa,catalyzing the third step

of citric acid cycle

1 MGI phenotypic allele

for Idh2 (no phenotypes)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004450	isocitrate dehydrogenase (NADP+) activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	--
GO:0030145	manganese ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for IDH2 (Your Favorite Gene powered by Ingenuity)

Citrate Cycle
Glutathione Metabolism

GeneDecks IDH2 for the pathways selected above

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5/42 Interacting proteins for IDH2 (ENSP00000331897³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IDH3G	ENSP00000217901³	STRING (score=.993)
ACO2	ENSP00000216254³	STRING (score=.984)
GPT2	ENSP00000345282³	STRING (score=.966)
ACO1	ENSP00000309477³	STRING (score=.964)
GPT	ENSP00000346821³	STRING (score=.96)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	NAS	8954790
GO:0006097	glyoxylate cycle	IEA	--
GO:0006099	tricarboxylic acid cycle	IEA	--
GO:0006102	isocitrate metabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDH2
2 Novoseek chemical compound relationships for IDH2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
isocitrate	89.41	11	17075901 (2), 8707889 (1), 15253443 (1), 16120687 (1) (see all 9)
pyruvate	33.81	2	8318002 (1), 2210862 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDH2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002168

Sigma-Aldrich siRNA for IDH2

Sigma-Aldrich shRNA for IDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002168

REFSEQ mRNAs for IDH2 gene:

NM_002168.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002168

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002168
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002168
                                 untagged cDNA clone in CMV expression vector: NM_002168

Additional cDNA sequence:

AK222916.1 AK294148.1 AK299987.1 AK312627.1 AK316388.1 BC009244.2 BC071828.1 CR590507.1

CR593087.1 CR593589.1 CR594870.1 CR595435.1 CR597564.1 CR597829.1 CR598530.1 CR599159.1

CR599284.1 CR600286.1 CR600938.1 CR602079.1 CR602902.1 CR604829.1 CR606440.1 CR606745.1

CR607058.1 CR607159.1 CR607742.1 CR610676.1 CR610749.1 CR610921.1 CR613707.1 CR615856.1

CR616318.1 CR617229.1 CR617266.1 CR617370.1 CR619261.1 CR619410.1 CR622745.1 CR625291.1

CR625730.1 CR625817.1 U52144.1 X69433.1

24/32 DOTS entries (see all 32 ):

DT.448959 DT.100808539 DT.92065665 DT.121027184 DT.100649521 DT.121027328 DT.100649506 DT.100649523

DT.100649536 DT.91766554 DT.95371733 DT.121027360 DT.95371734 DT.91808314 DT.100649511 DT.100649533

DT.121027162 DT.432480 DT.121027172 DT.121027397 DT.75168204 DT.86841012 DT.100649520 DT.100649527

24/703 AceView cDNA sequences (see all 703 ):

F37142 BM722584 CR619410 BM832433 BC009244 AW025010 CF127701 CR599159

BG397409 AA371843 BG105261 CR625730 AA573936 BE617248 CR602079 AJ346524

CR610921 BU859096 AL542553 CF994762 BM796735 BX419103 BU180421 BM509286

highest scoring ESTs for IDH2:

X69433 AA194522 AA776602 AL516205 AL516853 AL517046 AL544416 AL548933 AL551048 AL557001

Unigene Cluster for IDH2:

Isocitrate dehydrogenase 2 (NADP+), mitochondrial

Hs.596461 [show with all ESTs]

Unigene Representative Sequence: X69433

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IDH2 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:					-		-				-				-		-
SP2:					-		-				-				-
SP3:					-		-				-
SP4:					-						-
SP5:					-		-

About this scheme

ECgene alternative splicing isoforms for IDH2

1 Ensembl transcript including schematic representation:

ENST00000330062

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDH2

¹ / ² / ³

3 probe-sets matching IDH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32332_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X69433	1.00	1.00	1.00	1
210046_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U52144	0.40	0.67	0.55	1
210046_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IDH2 for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCCATATT

SOURCE GeneReport for Unigene cluster: Hs.596461
Expression variation in blood from EXPOLDB for IDH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDH2 gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IDH2¹	--	isocitrate dehydrogenase 2 (NADP+), mitochondrial	90.53(n) 96.36(a)	479043 XM_536192.2 XP_536192.2
chimpanzee (Pan troglodytes)	IDH2¹	--	isocitrate dehydrogenase 2 (NADP+), mitochondrial	99.63(n) 99.78(a)	453645 XM_510589.2 XP_510589.2
cow (Bos taurus)	IDH2¹	--	isocitrate dehydrogenase 2 (NADP+), mitochondrial	91.08(n) 96.24(a)	327669 NM_175790.2 NP_786984.1
rat (Rattus norvegicus)	Idh2¹	--	isocitrate dehydrogenase 2 (NADP+), mitochondrial	89.53(n) 94.69(a)	361596 NM_001014161.1 NP_001014183.1
mouse (Mus musculus)	Idh2^{1, 5}	7 (41.00 cM)⁵	isocitrate dehydrogenase 2 (NADP+), mitochondrial^{1, 5}	89.9(n)¹ 94.91(a)¹	269951¹ NM_173011.1¹ NP_766599.1¹ AF212319⁵ AI661450⁵ (see all 25)

About this table Species with no ortholog for IDH2

ENSEMBL Gene Tree for IDH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IDH2 gene

IDH1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/184 NCBI SNPs in IDH2 are shown (see all 184 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs4283211^1,2	A,C	88447943(+)	`AGAGTA/GGTCAA`	1	--	ng3¹		0	--	--	--	--
--	rs4280211^1,2	A	88447351(+)	`aattgA/Gtcggg`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs11540478^1,2	C,F,H	88429541(-)	`GGGACC/TGTCAC`	1	T/T	syn¹ ese³		5		NA EU WA	362
	rs16943901^1,2	F,H	88431376(+)	`ACATCT/CCCGTC`	1	G/G	syn¹ ese³		7		NA EU EA WA	550
	rs6496622^1,2	A,C,F,H	88439196(+)	`CAGAAC/TACCTG`	1	--	int¹		12		EU EA WA NA	1056
	rs8034938^1,2	A,C,F,H	88436631(+)	`ctttcC/Gttcct`	1	--	int¹		4		EU EA WA	416
	rs7177165^1,2	A,C,F,H	88433724(+)	`CCCAAC/TGCCAC`	1	--	int¹		4		EU EA WA	416
	rs7178604^1,2	A,C,F,H	88434163(+)	`ACAGCA/GATGTT`	1	--	int¹		8		EU EA WA	832
	rs10459702^1,2	A,C,F,H	88439397(+)	`ATAGAG/ACCCAG`	1	--	int¹		4		EU EA WA	420
--	rs9672249^1,2	A,C,F,H	88442190(+)	`CTTCAC/TTCCAT`	1	--	int¹		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for IDH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147650

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/29 PubMed articles for IDH2 gene (see all 29 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
IDH1 and IDH2 mutations in gliomas. (PubMed id 19228619)^{1, 3} Yan H....Bigner D.D. (2009)
Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation. (PubMed id 8707889)^{1, 3} Luo H.... Wu J. (1996)
Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization. (PubMed id 8954790)^{1, 3} Oh I.U....Huh T.L. (1996)
Inactivation of mitochondrial NADP+-dependent isocitrate dehydrogenase by hypochlorous acid. (PubMed id 18484410)³ Park S.Y....Park J.W. (2008)
Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. (PubMed id 18096511)³ Shin S.W....Park J.W. (2008)
Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs. (PubMed id 17854715)³ Kil I.S....Park J.W. (2007)
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). (PubMed id 16396496)³ Foster L.J....Klip A. (2006)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)³ Gevaert K.... Vandekerckhove J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3418	HGNC: 5383	AceView: IDH2	Ensembl:ENSG00000182054	euGenes: HUgn3418
ECgene: IDH2	H-InvDB: IDH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for IDH2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IDH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDH2		Antibodies for IDH2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDH2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Search Tocris compounds for IDH2

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IDH2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for IDH2

Summaries
for IDH2

Genomic Location
for IDH2

Proteins
for IDH2

Protein Domains/
Families
for IDH2

Gene Function
for IDH2

Pathways & Interactions
for IDH2

Drugs & Compounds
for IDH2

Transcripts
for IDH2

Expression
for IDH2

Orthologs
for IDH2

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SNPs/Variants
for IDH2

Disorders & Mutations
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Medical News
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDH2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor IDH2

Summariesfor IDH2

Genomic Locationfor IDH2

Proteinsfor IDH2

Protein Domains/Familiesfor IDH2

Gene Functionfor IDH2

Pathways & Interactionsfor IDH2

Drugs & Compoundsfor IDH2

Transcriptsfor IDH2

Expression for IDH2

Orthologsfor IDH2

Paralogsfor IDH2

SNPs/Variantsfor IDH2

Disorders & Mutationsfor IDH2

Medical Newsfor IDH2

Publicationsfor IDH2

Search for IDH2

Genome Databases showing IDH2

Other Databases showing IDH2

Specialized Databases showing IDH2

Licensable Technologiesfor IDH2

Servicesfor IDH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDH2

Summaries
for IDH2

Genomic Location
for IDH2

Proteins
for IDH2

Protein Domains/
Families
for IDH2

Gene Function
for IDH2

Pathways & Interactions
for IDH2

Drugs & Compounds
for IDH2

Transcripts
for IDH2

Expression
for IDH2

Orthologs
for IDH2

Paralogs
for IDH2

SNPs/Variants
for IDH2

Disorders & Mutations
for IDH2

Medical News
for IDH2

Publications
for IDH2

Licensable Technologies
for IDH2

Services
for IDH2