V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

IDH1 Gene

protein-coding GIFtS: 60

GC02M208809

isocitrate dehydrogenase 1 (NADP+), soluble
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.1.1.42 ^³
IDCD ^²
IDH ^², ³
IDP ^², ³
IDPC ^²
PICD ^², ³

Descriptions
Cytosolic NADP-isocitrate dehydrogenase ^³
NADP(+)-specific ICDH ^³
NADP+-specific ICDH ^²
NADP-dependent isocitrate dehydrogenase, cytosolic ^²
NADP-dependent isocitrate dehydrogenase, peroxisomal ^²
Oxalosuccinate decarboxylase ^², ³
isocitrate dehydrogenase 1 (NADP+), soluble ^²

External Ids
HGNC: 5382¹
Entrez Gene: 3417²
UniProtKB: O75874³
Ensembl: ENSG00000138413⁷

Search outside databases for aliases for IDH1 gene

Previous GC identifers: GC02M207376 GC02M207825 GC02M209064 GC02M209303 GC02M208926

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDH1:

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron

acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three

NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two

NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other

predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by

this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and

peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this

enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions,

such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions

that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic

enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IDH1 gene

Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q32-qter

IDH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M208809: (about GC identifiers)

Start:	208,809,198 bp from pter
End:	208,828,051 bp from pter
Size:	18,854 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874 (See protein sequence)

Recommended Name: Isocitrate dehydrogenase [NADP] cytoplasmic

Size: 414 amino acids; 46659 Da

Cofactor: Binds 1 magnesium or manganese ion per subunit

Subunit: Homodimer

Subcellular location: Cytoplasm. Peroxisome

Miscellaneous: Cancer mutations affecting Arg-132 are tissue-specific, and suggest that this

residue plays a unique role in the development of high-grade gliomas

PDB structure from and Proteopedia :

1T09 (3D)

1T0L (3D)

Secondary accessions: Q93090 Q9NTJ9 Q9UKW8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005887.2

ENSEMBL proteins:

ENSP00000260985

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Isocitrate dehydrogenase)
	Human Recombinant Proteins from Abnova (IDH1)

OriGene Purified Recombinant Human Protein: IDH1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005777	peroxisome	IEA	--
GO:0005829	cytosol	TAS	9866202

About this table

Antibodies for IDH1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Isocitrate dehydrogenase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IDH1

Assays for IDH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O75874

ProtoNet protein and cluster: O75874

1 Blocks protein family: IPB001804 Isocitrate/isopropylmalate dehydrogenase

UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDH1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005896

Applied Biosystems Silencer® siRNAs for IDH1

Sigma-Aldrich siRNA and siRNA Panels for IDH1

Sigma-Aldrich shRNA for IDH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IDH1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005896
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005896
untagged cDNA clones in CMV expression vector (see all 2): NM_005896

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005896

UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874

Catalytic activity: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Catalytic activity: Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Enzyme Number (IUBMB): EC 1.1.1.42

Genatlas biochemistry entry for IDH1:

isocitrate dehydrogenase 1,cytosolic,NADPH dependent,third step of citric acid cycle

1 MGI phenotypic allele

for Idh1 (no phenotypes)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004450	isocitrate dehydrogenase (NADP+) activity	TAS	9866202
GO:0016491	oxidoreductase activity	IEA	--
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	--
GO:0030145	manganese ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for IDH1 (Your Favorite Gene powered by Ingenuity)

Glutathione Metabolism
Citrate Cycle

GeneDecks IDH1 for the pathways selected above

About GeneDecksing

5/30 Interacting proteins for IDH1 (ENSP00000260985³) via UniProtKB, MINT, and/or STRING (see all 30 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACO2	ENSP00000216254³	STRING (score=.964)
ACO1	ENSP00000309477³	STRING (score=.956)
MDH1	ENSP00000233114³	STRING (score=.952)
GOT2	ENSP00000245206³	STRING (score=.917)
IDH3A	ENSP00000299518³	STRING (score=.911)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	9866202
GO:0006097	glyoxylate cycle	IEA	--
GO:0006099	tricarboxylic acid cycle	IEA	--
GO:0006102	isocitrate metabolic process	TAS	9866202
GO:0006749	glutathione metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDH1
7 Novoseek chemical compound relationships for IDH1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
isocitrate	94.63	53	11284679 (2), 9512021 (2), 9211842 (1), 10521434 (1) (see all 32)
nadp+	68.23	6	9512021 (3), 10521434 (1), 17029707 (1)
glucose 6-phosphate	48.88	5	10521434 (1), 16143603 (1), 8660340 (1), 12232660 (1)
nadph	41.94	10	9512021 (3), 10521434 (2), 8987537 (1), 12923220 (1) (see all 5)
glyceraldehyde 3-phosphate	33.16	2	8660340 (1), 15355353 (1)
calcium	0.00	4	15355353 (2)
fatty acid	0.00	3	10521434 (1), 8987537 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDH1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005896

Sigma-Aldrich siRNA and siRNA Panels for IDH1

Sigma-Aldrich shRNA for IDH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005896

REFSEQ mRNAs for IDH1 gene:

NM_005896.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005896

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005896
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005896
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005896

Additional cDNA sequence:

AF020038.1 AF113917.1 AK125247.1 AK302105.1 AK312242.1 AL136702.1 BC012846.1 BC021046.1

BC093020.1 BX537411.1 CR533522.1 CR536499.1 CR541695.1 CR594054.1 CR608733.1 U62389.1

24/33 DOTS entries (see all 33 ):

DT.100845600 DT.91776646 DT.219513 DT.120999209 DT.100766638 DT.120999216 DT.437002 DT.95162526

DT.107236 DT.100845598 DT.120999211 DT.99944670 DT.91776651 DT.95075652 DT.95162531 DT.120999163

DT.91698485 DT.100735322 DT.102830286 DT.120999132 DT.95162499 DT.95162529 DT.97809111 DT.120999133

24/528 AceView cDNA sequences (see all 528 ):

CR608733 BQ649977 BQ962023 BX417974 CB156132 BG030654 BE872584 BQ217274

F06739 BQ432452 BQ439424 AA327670 AA313574 AA904956 AA886789 BM470608

AA827594 AI263053 F03511 BG716785 BM796266 U62389 BF445518 CR594054

highest scoring ESTs for IDH1:

AF020038 AA075922 AA076246 AA218606 AA305236 AA313574 AA319329 AA337237 AA356019 AF113917

Unigene Cluster for IDH1:

Isocitrate dehydrogenase 1 (NADP+), soluble

Hs.593422 [show with all ESTs]

Unigene Representative Sequence: AF020038

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IDH1 (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13
SP1:																							-
SP2:											-		-										-
SP3:																																			-		-
SP4:			-		-						-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for IDH1

1 Ensembl transcript including schematic representation:

ENST00000345146

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDH1

¹ / ² / ³

5 probe-sets matching IDH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39023_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.99	AF020038	1.00	1.00	1.00	1
64372_r_at²^{, 3}	U95-C	2	1.00	0.97	0.97	1.01	AI971036	0.80	1.00	0.91	1
201193_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005896	0.60	1.00	0.82	1
201193_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555037_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IDH1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.593422
Expression variation in blood from EXPOLDB for IDH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDH1 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IDH1¹	--	isocitrate dehydrogenase 1 (NADP+), soluble	92.83(n) 96.86(a)	478889 XM_536047.2 XP_536047.2
chimpanzee (Pan troglodytes)	IDH1¹	--	isocitrate dehydrogenase 1 (NADP+), soluble	99.28(n) 99.52(a)	460113 XM_001142197.1 XP_001142197.1
cow (Bos taurus)	IDH1¹	--	isocitrate dehydrogenase 1 (NADP+), soluble	91.14(n) 95.65(a)	281235 NM_181012.3 NP_851355.2
rat (Rattus norvegicus)	Idh1¹	--	isocitrate dehydrogenase 1 (NADP+), soluble	90.42(n) 96.38(a)	24479 NM_031510.1 NP_113698.1
mouse (Mus musculus)	Idh1^{1, 5}	1 (29.80 cM)⁵	isocitrate dehydrogenase 1 (NADP+), soluble^{1, 5}	90.34(n)¹ 95.41(a)¹	15926¹ NM_010497.2¹ NP_034627.2¹ AF020039⁵ AI314845⁵ (see all 21)

About this table Species with no ortholog for IDH1

ENSEMBL Gene Tree for IDH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IDH1 gene

IDH2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/127 NCBI SNPs in IDH1 are shown (see all 127 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10207062^1,2	A,C,F,H	208829212(+)	`TTATTT/GATTTA`	1	--	ng3¹ tfbs³		4		EU EA WA	418
	rs16840781^1,2	C,F,H	208809159(+)	`TGTAGC/TGTGGT`	1	--	ng5¹		8		NA EU EA WA	590
--	rs6730955^1,2	C,F,H	208809556(+)	`CACTCA/CTACTT`	1	--	ut3¹		4		EU EA WA	416
	rs12478635^1,2	C,F,H	208828503(+)	`CTTTGG/TCTGAA`	1	--	ng3¹		10		EU EA WA MN	2054
--	rs11888463^1,2	C,F	208808857(+)	`ATCCAT/CTTTTT`	1	--	ng5¹		3		NA	140
--	rs1446325^1,2	A,C	208828885(+)	`ttcagC/Tagccc`	1	--	ng3¹		0	--	--	--	--
--	rs12694100^1,2	A,C	208829434(+)	`tgcctC/Tggcct`	1	--	ng3¹		0	--	--	--	--
	rs34218846^1,2	C,F	208816562(+)	`GGCAAC/TACCAC`	1	V/I	mis¹		5		NA EU EA WA	498
--	rs11554138^1,2	H	208824466(-)	`AAATGA/CCACGA`	1	T/P	mis¹ ese³		4		EU EA WA	406
--	rs1044416^1,2	C	208809712(-)	`TGATAA/GCCACA`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IDH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147700

UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874

Defects in IDH1 are a cause of glioblastoma multiforme (GBM) [MIM:137800]; also called

familial glioma of brain. Gliomas are central nervous system neoplasms derived from glial cells

and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas

5 Novoseek disease relationships for IDH1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligodendroglioma	48.12	4	19246647 (3), 18985363 (2), 19228619 (1)
astrocytoma	28.92	4	19246647 (3), 18985363 (2), 19228619 (1)
glioblastoma	26.73	10	18985363 (4), 19246647 (3), 19228619 (2)
glioma	25.65	6	19228619 (3), 18985363 (1), 19117336 (1), 19246647 (1) (see all 5)
tumors	0.00	11	19228619 (4), 19359588 (4), 19117336 (2), 18985363 (1)

About this table

Human Gene Mutation Database: IDH1
Human Genome Epidemiology Navigator: IDH1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/58 PubMed articles for IDH1 gene (see all 58 ):

The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)- dependent isocitrate dehydrogenase. (PubMed id 10521434)^{1, 3, 4} Geisbrecht B.V. and Gould S.J. (1999)
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. (PubMed id 19117336)^{1, 3, 4} Bleeker F.E....Bardelli A. (2009)
An integrated genomic analysis of human glioblastoma multiforme. (PubMed id 18772396)^{1, 3, 4} Parsons D.W....Kinzler K.W. (2008)
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. (PubMed id 15173171)^{1, 3, 4} Xu X.... Ding J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. (PubMed id 9866202)^{3, 4} Nekrutenko A.... Baker R.J. (1998)
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. (PubMed id 19246647)^{1, 3} Watanabe T....Ohgaki H. (2009)
IDH1 and IDH2 mutations in gliomas. (PubMed id 19228619)^{1, 3} Yan H....Bigner D.D. (2009)
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. (PubMed id 19359588)^{1, 3} Zhao S....Xiong Y. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3417	HGNC: 5382	AceView: IDH1	Ensembl:ENSG00000138413	euGenes: HUgn3417
ECgene: IDH1	H-InvDB: IDH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase

Licensable Technologies for IDH1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IDH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDH1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDH1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IDH1)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Isocitrate dehydrogenase)
	Antibodies (Isocitrate dehydrogenase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for IDH1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IDH1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IDH1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

IDH1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for IDH1

Summaries
for IDH1

Genomic Location
for IDH1

Proteins
for IDH1

Protein Domains/
Families
for IDH1

Gene Function
for IDH1

Pathways & Interactions
for IDH1

Drugs & Compounds
for IDH1

Transcripts
for IDH1

Expression
for IDH1

Orthologs
for IDH1

Paralogs
for IDH1

SNPs/Variants
for IDH1

Disorders & Mutations
for IDH1

Medical News
for IDH1

Publications
for IDH1

Search for IDH1

Genome Databases showing IDH1

Other Databases showing IDH1

Specialized Databases showing IDH1

Licensable Technologies
for IDH1

Services
for IDH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDH1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor IDH1

Summariesfor IDH1

Genomic Locationfor IDH1

Proteinsfor IDH1

Protein Domains/Familiesfor IDH1

Gene Functionfor IDH1

Pathways & Interactionsfor IDH1

Drugs & Compoundsfor IDH1

Transcriptsfor IDH1

Expression for IDH1

Orthologsfor IDH1

Paralogsfor IDH1

SNPs/Variantsfor IDH1

Disorders & Mutationsfor IDH1

Medical Newsfor IDH1

Publicationsfor IDH1

Search for IDH1

Genome Databases showing IDH1

Other Databases showing IDH1

Specialized Databases showing IDH1

Licensable Technologiesfor IDH1

Servicesfor IDH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDH1

Summaries
for IDH1

Genomic Location
for IDH1

Proteins
for IDH1

Protein Domains/
Families
for IDH1

Gene Function
for IDH1

Pathways & Interactions
for IDH1

Drugs & Compounds
for IDH1

Transcripts
for IDH1

Expression
for IDH1

Orthologs
for IDH1

Paralogs
for IDH1

SNPs/Variants
for IDH1

Disorders & Mutations
for IDH1

Medical News
for IDH1

Publications
for IDH1

Licensable Technologies
for IDH1

Services
for IDH1