Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IDH1 Gene

protein-coding   GIFtS: 74
GCID: GC02M209100

Isocitrate Dehydrogenase 1 (NADP+), Soluble

  See IDH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Isocitrate Dehydrogenase 1 (NADP+), Soluble1 2     IDCD2
Oxalosuccinate Decarboxylase2 3     IDPC2
IDH2 3     Epididymis Luminal Protein 2162
IDP2 3     Epididymis Secretory Protein Li 262
PICD2 3     Isocitrate Dehydrogenase [NADP] Cytoplasmic2
NADP(+)-Specific ICDH2 3     NADP-Dependent Isocitrate Dehydrogenase, Cytosolic2
EC 1.1.1.423 8     NADP-Dependent Isocitrate Dehydrogenase, Peroxisomal2
HEL-2162     Cytosolic NADP-Isocitrate Dehydrogenase3
HEL-S-262     

External Ids:    HGNC: 53821   Entrez Gene: 34172   Ensembl: ENSG000001384137   OMIM: 1477005   UniProtKB: O758743   

Export aliases for IDH1 gene to outside databases

Previous GC identifers: GC02M207376 GC02M207825 GC02M209064 GC02M209303 GC02M208926 GC02M208809 GC02M200949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IDH1 Gene:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes
belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which
localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is
mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein
encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It
contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests
roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs
to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation
of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Sep
2013)

GeneCards Summary for IDH1 Gene:
IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble) is a protein-coding gene. Diseases associated with IDH1 include periosteal chondrosarcoma, and glioma somatic. GO annotations related to this gene include magnesium ion binding and protein homodimerization activity. An important paralog of this gene is IDH2.

Gene Wiki entry for IDH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IDH1 gene promoter:
         STAT5B   Pax-5   HOXA3   MIF-1   Evi-1   C/EBPalpha   GATA-1   CHOP-10   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IDH1 promoter sequence
   Search Chromatin IP Primers for IDH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q34

IDH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IDH1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M209100:  view genomic region     (about GC identifiers)

Start:
209,100,951 bp from pter      End:
209,130,798 bp from pter
Size:
29,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874 (See protein sequence)
Recommended Name: Isocitrate dehydrogenase [NADP] cytoplasmic  
Size: 414 amino acids; 46659 Da
Cofactor: Binds 1 magnesium or manganese ion per subunit
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for IDH1 (see all 12):
1T09 (3D)        1T0L (3D)        3INM (3D)        3MAP (3D)        3MAR (3D)        3MAS (3D)    
Secondary accessions: Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8

Explore the universe of human proteins at neXtProt for IDH1: NX_O75874

Explore proteomics data for IDH1 at MOPED

Post-translational modifications: 

  • Acetylation at Lys-374 dramatically reduces catalytic activity (By similarity)1
  • Ubiquitination2 at Lys126, Lys224, Lys233, Lys321
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IDH1 (O75874) (see all 19)
     EAAHGTV  IASIFAW  HGTVTRH  GDQYRAT 


    See IDH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269315.1  NP_001269316.1  NP_005887.2  

    ENSEMBL proteins: 
     ENSP00000260985   ENSP00000410513   ENSP00000390265   ENSP00000391075   ENSP00000409045  
     ENSP00000396787  
    Reactome Protein details: O75874

    IDH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IDH1 (Isocitrate Dehydrogenase 1/IDH1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IDH1
    OriGene Protein Over-expression Lysate for IDH1
    OriGene MassSpec for IDH1
    OriGene Custom Protein Services for IDH1
    GenScript Custom Purified and Recombinant Proteins Services for IDH1
    Novus Biologicals IDH1 Proteins
    Sino Biological Recombinant Protein for IDH1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IDH1
    Cloud-Clone Corp. Proteins for IDH1

     
    Search eBioscience for Proteins for IDH1 

    IDH1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IDH1
    R&D Systems Antibodies for IDH1 (Isocitrate Dehydrogenase 1/IDH1)
    Cell Signaling Technology (CST) Antibodies for IDH1 
    OriGene Antibodies for IDH1
    OriGene Custom Antibody Services for IDH1
    Novus Biologicals IDH1 Antibodies
    Abcam antibodies for IDH1
    Cloud-Clone Corp. Antibodies for IDH1
    ThermoFisher Antibody for IDH1
    LSBio Antibodies in human, mouse, rat for IDH1

    IDH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IDH1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IDH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IDH1
    Cloud-Clone Corp. CLIAs for IDH1
    Search eBioscience for ELISAs for IDH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR004790 Isocitrate_DH_NADP
     IPR019818 IsoCit/isopropylmalate_DH_CS
     IPR024084 IsoPropMal-DH-like_dom

    Graphical View of Domain Structure for InterPro Entry O75874

    ProtoNet protein and cluster: O75874

    1 Blocks protein domain: IPB001804 Isocitrate/isopropylmalate dehydrogenase

    UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874
    Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family


    Find genes that share domains with IDH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDHC_HUMAN, O75874
    Catalytic activity: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=49 uM for NADP; KM=29 uM for magnesium chloride; KM=65 uM
    for isocitrate;

         Genatlas biochemistry entry for IDH1:
    isocitrate dehydrogenase 1,cytosolic,NADPH dependent,third step of citric acid cycle

         Enzyme Number (IUBMB): EC 1.1.1.421 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA19935646
    GO:0004450isocitrate dehydrogenase (NADP+) activity IDA10521434
    GO:0005102receptor binding IPI--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0042803protein homodimerization activity IPI19935646
         
    Find genes that share ontologies with IDH1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IDH1:
     Decreased p24 protein expressi 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Idh1):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with IDH1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IDH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IDH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IDH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IDH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IDH1:
    hsa-mir-1226-3p (MIRT036500), hsa-mir-30a-5p (MIRT005125), hsa-mir-335-5p (MIRT017645)

    Block miRNA regulation of human, mouse, rat IDH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IDH1 (see all 31):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-4318 hsa-miR-520d-5p hsa-miR-25 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIDH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IDH1
    Predesigned siRNA for gene silencing in human, mouse, rat IDH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IDH1

    Clone
    Products:
         
    OriGene clones in human, mouse for IDH1 (see all 8)
    OriGene ORF clones in mouse, rat for IDH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IDH1 (NM_005896)
    Sino Biological Human cDNA Clone for IDH1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDH1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IDH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IDH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDH1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12083) for IDH1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IDHC_HUMAN, O75874: Cytoplasm. Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    peroxisome5
    mitochondrion2
    nucleus2
    chloroplast1
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA10521434
    GO:0005782peroxisomal matrix TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IDH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IDH1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    3Carbon metabolism
    Carbon metabolism0.38
    2-Oxocarboxylic acid metabolism0.00
    Biosynthesis of amino acids0.38
    4NADPH regeneration
    NADPH regeneration
    Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate0.00
    5Citric acid cycle (TCA cycle)
    Citrate cycle (TCA cycle)0.55


    Find genes that share SuperPaths with IDH1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IDH1
        Glucose / Energy Metabolism

    1 BioSystems Pathway for IDH1
        Glutathione metabolism


    2 Reactome Pathways for IDH1
        NADPH regeneration
    Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate


    Selected Kegg Pathways  (Kegg details for IDH1) (see all 7):
        Citrate cycle (TCA cycle)
    Glutathione metabolism
    Metabolic pathways
    Carbon metabolism
    2-Oxocarboxylic acid metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDH1: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IDH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IDH1 (O758742, 3 ENSP000002609854) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZHX1Q9UKY13, ENSP000002978574I2D: score=5 STRING: ENSP00000297857
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    ASLP044243, ENSP000003071884I2D: score=1 STRING: ENSP00000307188
    FHP079543, ENSP000003555184I2D: score=1 STRING: ENSP00000355518
    IDH3GP515533, ENSP000002179014I2D: score=1 STRING: ENSP00000217901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006097glyoxylate cycle IEA--
    GO:0006099tricarboxylic acid cycle IEA--
    GO:0006102isocitrate metabolic process IDA10521434
    GO:00061032-oxoglutarate metabolic process TAS--
    GO:0006740NADPH regeneration TAS--

    Find genes that share ontologies with IDH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IDH1 (IDHC)

    8 HMDB Compounds for IDH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Isocitric acid1-Hydroxy-1,2,3-propanetricarboxylate (see all 15)320-77-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Oxalosuccinic acidOxalosuccinate (see all 2)1948-82-9--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--

    2 DrugBank Compounds for IDH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423
    Isocitric Acid-- 320-77-4target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for IDH1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isocitrate 96.2 105 11284679 (2), 19935646 (2), 20142433 (2), 19636000 (2) (see all 55)
    2-hydroxyglutarate 87.9 14 20171147 (4), 20127344 (1), 19935646 (1), 20142433 (1) (see all 5)
    alpha-ketoglutarate 75.4 17 10521434 (2), 19935646 (2), 11912232 (1), 19359588 (1) (see all 8)
    nadp+ 62.1 6 9512021 (3), 10521434 (1), 17029707 (1)
    glucose 6-phosphate 51.9 5 10521434 (1), 16143603 (1), 8660340 (1), 12232660 (1)
    nadph 46.4 28 20127344 (5), 9512021 (3), 10521434 (2), 8987537 (1) (see all 6)
    malate 46.4 1 8959151 (1)
    nicotinamide 33.2 1 9220992 (1)
    glyceraldehyde 3-phosphate 24.4 2 8660340 (1), 15355353 (1)
    adenine 19.5 1 9211842 (1)



    Find genes that share compounds with IDH1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IDH1 gene (3 alternative transcripts): 
    NM_001282386.1  NM_001282387.1  NM_005896.3  

    Unigene Cluster for IDH1:

    Isocitrate dehydrogenase 1 (NADP+), soluble
    Hs.593422  [show with all ESTs]
    Unigene Representative Sequence: AF020038
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345146(uc002vcu.3) ENST00000446179(uc002vct.3) ENST00000415913(uc002vcs.3)
    ENST00000484575 ENST00000415282 ENST00000462386 ENST00000417583 ENST00000451391
    ENST00000481557
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IDH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IDH1 (see all 31):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-4318 hsa-miR-520d-5p hsa-miR-25 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIDH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IDH1
    Predesigned siRNA for gene silencing in human, mouse, rat IDH1
    Clone
    Products:
         
    OriGene clones in human, mouse for IDH1 (see all 8)
    OriGene ORF clones in mouse, rat for IDH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IDH1 (NM_005896)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IDH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDH1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IDH1
    OriGene qSTAR qPCR primer pairs in human, mouse for IDH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IDH1
      QuantiTect SYBR Green Assays in human, mouse, rat IDH1
      QuantiFast Probe-based Assays in human, mouse, rat IDH1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12083) for IDH1 

    Additional mRNA sequence: 

    AF020038.1 AF113917.1 AK125247.1 AK302105.1 AK312242.1 AL136702.1 BC012846.1 BC021046.1 
    BC093020.1 BX537411.1 CR533522.1 CR536499.1 CR541695.1 U62389.1 

    Selected DOTS entries (see all 31):

    DT.100845600  DT.91776646  DT.219513  DT.120999209  DT.100766638  DT.120999216  DT.95162526  DT.437002 
    DT.100845598  DT.120999211  DT.99944670  DT.91776651  DT.95162531  DT.91698485  DT.100735322  DT.102830286 
    DT.95075652  DT.120999132  DT.120999133  DT.120999159  DT.95162499  DT.95162529  DT.97809111  DT.107236 

    Selected AceView cDNA sequences (see all 528):

    BM699150 AI358926 AA115199 AA904956 CR608733 BC012846 NM_005896 BI858183 
    BX417974 N79322 CB156132 BG388983 CB215509 AA886789 BG716785 AL547064 
    AA883770 AU125661 BM454697 CB130734 CB269067 BX279534 BF445518 AI824349 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IDH1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                    -                                                                     
    SP2:                                -     -                             -                                                                     
    SP3:                                                                                                        -     -                           
    SP4:        -     -                 -     -                                                                                                   
    SP5:                                -     -                                                                                                   


    ECgene alternative splicing isoforms for IDH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IDH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGAACGA
    IDH1 Expression
    About this image


    IDH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    IDH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IDH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593422
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IDH1: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IDH1
    OriGene qSTAR qPCR primer pairs in human, mouse for IDH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IDH1
    QuantiTect SYBR Green Assays in human, mouse, rat IDH1
    QuantiFast Probe-based Assays in human, mouse, rat IDH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IDH1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Idh11 , 5 isocitrate dehydrogenase 1 (NADP+), soluble1, 5 90.42(n)1
    95.65(a)1
      1 (32.91 cM)5
    159261  NM_010497.31  NP_034627.31 
     651586165 
    chicken
    (Gallus gallus)
    Aves IDH11 isocitrate dehydrogenase 1 (NADP+), soluble 80(n)
    90(a)
      424112  XM_004942681.1  XP_004942738.1 
    lizard
    (Anolis carolinensis)
    Reptilia IDH16
    isocitrate dehydrogenase 1 (NADP+), soluble
    88(a)
    1 ↔ 1
    4(90485783-90514624)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.170632 Transcribed sequence with moderate similarity to protein more 81.22(n)    BX708884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663182 Danio rerio mRNA similar to isocitrate dehydrogenase more 76.82(n)    BC046894.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Idh1 Isocitrate dehydrogenase 67.56(n)
    72.62(a)
      44291  NM_143787.3  NP_652044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F59B8.23
    idh-11
    isocitrate dehydrogenase3
    idh-11
    74(a)
    (best of 2)3
    67.24(n)1
    75.98(a)1
      IV(9439443-9440945)3
    1777751  NM_001268463.11  NP_001255392.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IDP1(YDL066W)4
    IDP11
    Mitochondrial NADP-specific isocitrate dehydrogenase, more4
    IDP11
    63.61(n)1
    68.62(a)1
      4(334835-336121)4
    8514931, 4  NP_010217.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons cICDH1 cICDH 63.48(n)
    68.26(a)
      842905  NM_105265.4  NP_176768.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06545001 Os01g0654500 64.16(n)
    68.92(a)
      4324176  NM_001050284.1  NP_001043749.1 


    ENSEMBL Gene Tree for IDH1 (if available)
    TreeFam Gene Tree for IDH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IDH1 gene
    IDH22  
    1 SIMAP similar gene for IDH1 using alignment to 8 protein entries:     IDHC_HUMAN (see all proteins):
    IDH2

    Find genes that share paralogs with IDH1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IDH1
    PGOHUM00000243057


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IDH1 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0554544
    A glioma sample4--see VAR_0554542 R G mis40--------
    VAR_0554574
    A glioma sample4--see VAR_0554572 R S mis40--------
    VAR_0554564
    A glioma sample4--see VAR_0554562 R L mis40--------
    VAR_0554554
    A glioma sample4--see VAR_0554552 R H mis40--------
    VAR_0360134
    Colorectal cancer4--see VAR_0360132 R C mis40--------
    rs1219134991,2
    Cuntested1208501331(-) TAGGTA/C/TGTCAT 3 S R C mis10--------
    rs1880156211,2
    --208488779(+) GTCTCA/GAACTC 1 -- ds50010--------
    rs118884631,2
    C,F,H--208488831(+) ATCCAT/CTTTTT 1 -- ds50015Minor allele frequency- C:0.03NA WA 264
    rs1483558101,2
    --208488887(+) AAGTCC/TCTTAT 1 -- ds50010--------
    rs45054621,2
    H--208488977(+) ATTCTC/ATAATA 1 -- ds50014Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for IDH1 (209100951 - 209130798 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IDH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525747CNV Loss19592680
    nsv834517CNV Loss17160897
    nsv875751CNV Gain21882294

    Human Gene Mutation Database (HGMD): IDH1
    5 Site Specific Mutation Identification with PCR Assays for IDH1:
    Cosmic IdAA Change
    28747p.R132C
    28748p.R132S
    28746p.R132H
    28749p.R132G
    28750p.R132L
    Selected Site Specific Cancer Mutation PCR Panels containing IDH1 (see all 8):
    Hematopoietic Neoplasms
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Myelodysplastic Syndromes
    Brain Cancers
    SeqTarget long-range PCR primers for resequencing IDH1
    DNA2.0 Custom Variant and Variant Library Synthesis for IDH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147700   
    OMIM disorders: 137800  
    UniProtKB/Swiss-Prot: IDHC_HUMAN, O75874
  • Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from
    glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes,
    oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene
    represented in this entry is involved in disease pathogenesis. Mutations affecting Arg-132 are tissue-specific,
    and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132
    to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to
    alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of
    R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors

  • Selected diseases for IDH1 (see all 26):    
    About MalaCards
    periosteal chondrosarcoma    glioma somatic    metaphyseal chondromatosis with d-2-hydroxyglutaric aciduria    diffuse astrocytoma
    extraventricular neurocytoma    interval angle-closure glaucoma    spindle cell hemangioma    enchondroma
    intracranial chondrosarcoma    papillary glioneuronal tumor    angiocentric glioma    intraductal papilloma
    d-2-hydroxyglutaric aciduria    gliomatosis cerebri    chondroblastic osteosarcoma    odontoma
    ollier disease    dysembryoplastic neuroepithelial tumor    2-hydroxyglutaric aciduria    oligoastrocytoma

    6 diseases from the University of Copenhagen DISEASES database for IDH1:
    Malignant glioma     Intraductal papilloma     Leukemia     D-2-hydroxyglutaric aciduria
    Brain cancer     Interval angle-closure glaucoma

    Find genes that share disorders with IDH1           About GenesLikeMe

    8 Novoseek inferred disease relationships for IDH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligodendroglioma 76.8 14 19246647 (3), 18985363 (2), 19554337 (2), 19915484 (1) (see all 8)
    glioma 73.1 66 20077503 (6), 19765000 (6), 19636000 (5), 20131059 (4) (see all 21)
    glioblastoma 69.9 49 20127344 (8), 18985363 (4), 19246647 (3), 19765000 (3) (see all 10)
    astrocytoma 61.2 12 19246647 (3), 18985363 (2), 19554337 (2), 19915484 (1) (see all 7)
    pilocytic astrocytoma 59.6 1 18985363 (1), 19667985 (1)
    somatic mutations 43.5 4 20127344 (1), 19554337 (1), 19228619 (1), 19117336 (1) (see all 5)
    tumors 10.2 26 19228619 (4), 19359588 (4), 19554337 (2), 19117336 (2) (see all 12)
    cancer 0 2 20129244 (1), 20368543 (1)

    Genetic Association Database (GAD): IDH1
    Human Genome Epidemiology (HuGE) Navigator: IDH1 (55 documents)

    Export disorders for IDH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IDH1 gene, integrated from 10 sources (see all 366):
    (articles sorted by number of sources associating them with IDH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. (PubMed id 19765000)1, 4, 9 Sonoda Y....Tominaga T. (Cancer Sci. 2009)
    2. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. (PubMed id 19246647)1, 4, 9 Watanabe T....Ohgaki H. (Am. J. Pathol. 2009)
    3. The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)- dependent isocitrate dehydrogenase. (PubMed id 10521434)1, 2, 9 Geisbrecht B.V. and Gould S.J. (J. Biol. Chem. 1999)
    4. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. (PubMed id 19636000)1, 4, 9 Sanson M....Delattre J.Y. (J. Clin. Oncol. 2009)
    5. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. (PubMed id 20097881)1, 4, 9 Chou W.C....Tien H.F. (Blood 2010)
    6. Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing. (PubMed id 20131059)1, 4, 9 Felsberg J....Reifenberger G. (Acta Neuropathol. 2010)
    7. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. (PubMed id 19554337)1, 4, 9 Hartmann C....von Deimling A. (Acta Neuropathol. 2009)
    8. IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. (PubMed id 19117336)1, 2, 9 Bleeker F.E.... Bardelli A. (Hum. Mutat. 2009)
    9. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. (PubMed id 19935646)1, 2, 9 Dang L....Su S.M. (Nature 2009)
    10. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. (PubMed id 19805672)1, 4, 9 Weller M....Loeffler M. (J. Clin. Oncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3417 HGNC: 5382 AceView: IDH1 Ensembl:ENSG00000138413 euGenes: HUgn3417
    ECgene: IDH1 Kegg: 3417 H-InvDB: IDH1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IDH1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IDH1 gene:
    Search GeneIP for patents involving IDH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IDH1
     
     EMD Millipore genomic analysis products

      
     Antibodies for IDH1 (Isocitrate Dehydrogenase 1/IDH1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IDH1 (Isocitrate Dehydrogenase 1/IDH1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IDH1   OriGene RNAi products in human, mouse, rat for IDH1  
     OriGene qPCR primer pairs and template standards for IDH1   OriGene Protein Over-expression Lysate for IDH1  
     OriGene MassSpec something-or-other for IDH1   OriGene clones in human, mouse for IDH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IDH1   OriGene Purified Protein for IDH1  
     OriGene ORF clones in mouse, rat for IDH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IDH1   OriGene Custom Protein Services for IDH1  

     
     
     Block miRNA regulation of human, mouse, rat IDH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IDH1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IDH1 Predesigned siRNA for gene silencing in human, mouse, rat IDH1
     QuantiFast Probe-based Assays in human, mouse, rat IDH1 QuantiTect SYBR Green Assays in human, mouse, rat IDH1
     PCR Arrays including human, mouse, rat IDH1 Search Chromatin IP Primers for IDH1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IDH1  Search GeneGlobe Interaction Network for IDH1
     Regulatory tfbs in IDH1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IDH1 GenScript cDNA clones with any tag delivered in your preferred vector for IDH1
     GenScript Custom Assay Services for IDH1 GenScript Custom overexpressing Cell Line Services for IDH1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for IDH1 

     Search Tocris compounds for IDH1 (IDHC)
     Proteins for IDH1
     Browse Sino Biological Cell Lysates
     cDNA Clones for IDH1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IDH1 antibodies
     IDH1 proteins
     Antibodies for IDH1
     See all of Abcam's Antibodies, Kits and Proteins for IDH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IDH1
     Proteins for IDH1
     Antibodies for IDH1
     ELISAs for IDH1
     CLIAs for IDH1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IDH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IDH1
     SwitchGear 3'UTR luciferase reporter plasmids for IDH1
     SwitchGear Promoter luciferase reporter plasmids for IDH1
     ThermoFisher Antibody for IDH1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IDH1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IDH1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IDH1
     LSBio Antibodies in human, mouse, rat for IDH1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IDH1
      Search eBioscience for proteins for IDH1
      Search eBioscience for elisas for IDH1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IDH1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4