Aliases for IDH1 Gene
External Ids for IDH1 Gene
Previous GeneCards Identifiers for IDH1 Gene
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for IDH1 Gene
IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic) is a Protein Coding gene. Diseases associated with IDH1 include Glioma Susceptibility 1 and Metaphyseal Enchondromatosis With D-2-Hydroxyglutaric Aciduria. Among its related pathways are Peroxisome and NADPH regeneration. GO annotations related to this gene include protein homodimerization activity and magnesium ion binding. An important paralog of this gene is IDH2.