Aliases for IDE Gene
External Ids for IDE Gene
Previous GeneCards Identifiers for IDE Gene
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
GeneCards Summary for IDE Gene
IDE (Insulin-Degrading Enzyme) is a Protein Coding gene. Diseases associated with IDE include alzheimer disease-2 and cerebral amyloid angiopathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Alzheimers disease. GO annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is NRD1.
UniProtKB/Swiss-Prot for IDE Gene
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).