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IDE Gene

protein-coding GIFtS: 68

GC10M094201

insulin-degrading enzyme
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.56 ^³
FLJ35968 ^²
INSULYSIN ^²
Insulinase ^³
Insulysin ^³
OTTHUMP00000020097 ^²
insulinase ^²

Descriptions
Insulin protease ^³
insulin-degrading enzyme ^²

External Ids
HGNC: 5381¹
Entrez Gene: 3416²
UniProtKB: P14735³
Ensembl: ENSG00000119912⁷

Search outside databases for aliases for IDE gene

Previous GC identifers: GC10M093095 GC10M093435 GC10M094342 GC10M093878

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDE:

This gene may belong to a protease family responsible for intercellular peptide signalling. Though

its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme

is thought to be involved in the termination of the insulin response. [provided by RefSeq]

UniProtKB/Swiss-Prot: IDE_HUMAN, P14735

Function: May play a role in the cellular processing of insulin. May be involved in intercellular

peptide signaling

Gene Wiki entry for IDE (Insulin_degrading_enzyme)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IDE gene

Entrez Gene cytogenetic band: 10q23-q25 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23-q25

IDE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M094201: (about GC identifiers)

Start:	94,203,580 bp from pter
End:	94,323,832 bp from pter
Size:	120,253 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IDE_HUMAN, P14735 (See protein sequence)

Recommended Name: Insulin-degrading enzyme

Size: 1019 amino acids; 117968 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Homodimer (Probable)

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2G47 (3D)

2G48 (3D)

2G49 (3D)

2G54 (3D)

2G56 (3D)

2JBU (3D)

2JG4 (3D)

2WBY (3D)

2WC0 (3D)

3CWW (3D)

Secondary accessions: Q5T5N2

Post-translational modifications:

The N-terminus is blocked¹

REFSEQ proteins: NP_004960.2

ENSEMBL proteins:

ENSP00000265986 ENSP00000360637

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IDE (Insulysin/IDE)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Insulin degrading enzyme / IDE)
	Human Recombinant Proteins from Abnova (IDE)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	9830016
GO:0005625	soluble fraction	TAS	9830016
GO:0005737	cytoplasm	IEA	--
GO:0005777	peroxisome	TAS	8425612

About this table

Antibodies for IDE:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IDE
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for IDE (Insulysin/IDE)
	Antibodies from Abcam (Insulin degrading enzyme / IDE), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IDE

Assays for IDE:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14735

ProtoNet protein and cluster: P14735

1 Blocks protein family: IPB001431 Insulinase-like peptidase

UniProtKB/Swiss-Prot: IDE_HUMAN, P14735

Similarity: Belongs to the peptidase M16 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDE)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004969

Applied Biosystems Silencer® siRNAs for IDE

Sigma-Aldrich siRNA and siRNA Panels for IDE

Sigma-Aldrich shRNA for IDE

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IDE
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004969
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004969
untagged cDNA clone in CMV expression vector: NM_004969

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004969

UniProtKB/Swiss-Prot: IDE_HUMAN, P14735

Function: May play a role in the cellular processing of insulin. May be involved in intercellular

peptide signaling

Catalytic activity: Degradation of insulin, glucagon and other polypeptides. No action on proteins

Enzyme Number (IUBMB): EC 3.4.24.56

Genatlas biochemistry entry for IDE:

insulin degrading enzyme,cytosolic metalloproteinase (110kDa)

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ide):

homeostasis/metabolism

nervous system

normal

other

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	2293021
GO:0004871	signal transducer activity	TAS	2293021 3059494
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for IDE (Your Favorite Gene powered by Ingenuity)

Lysine Degradation
Purine Metabolism

GeneDecks IDE for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IDE

5/22 Interacting proteins for IDE (ENSP00000265986³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INS	ENSP00000370731³	STRING (score=.993)
SLC30A8	ENSP00000297345³	STRING (score=.95)
MME	ENSP00000353679³	STRING (score=.938)
NR3C1	ENSP00000231509³	STRING (score=.936)
GYPC	ENSP00000259254³	STRING (score=.914)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	9830016
GO:0007165	signal transduction	NAS	2293021
GO:0007548	sex differentiation	TAS	8425612

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDE
10 Novoseek chemical compound relationships for IDE gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thermolysin	61.16	4	7738784 (2), 8104941 (1), 7806544 (1)
1,10-phenanthroline	50.75	5	7789307 (1), 7494830 (1), 8024692 (1), 7738784 (1) (see all 5)
zinc	47.19	25	7806544 (4), 18621727 (2), 8104941 (1), 9128138 (1) (see all 13)
p-chloromercuribenzoate	42.38	1	7494830 (1)
leucine	26.27	3	9231799 (1), 8463315 (1)
glucose	23.02	19	16292511 (3), 12634421 (2), 17051221 (1), 15277398 (1) (see all 12)
atp	16.58	32	19384407 (4), 17613531 (3), 15494400 (2), 16723115 (2) (see all 6)
lipid	0.00	1	18506847 (1)
histidine	0.00	2	15749695 (1)
phosphatidylinositol	0.00	2	16186174 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IDE)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004969

Sigma-Aldrich siRNA and siRNA Panels for IDE

Sigma-Aldrich shRNA for IDE

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004969

REFSEQ mRNAs for IDE gene:

NM_004969.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004969

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004969
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004969
                                 untagged cDNA clone in CMV expression vector: NM_004969

Additional cDNA sequence:

AB209204.1 AK093287.1 AK302578.1 AK312810.1 AK316407.1 BC036188.1 BC096336.1 BC096337.1

BC096338.1 BC096339.3 BX648462.1 M21188.1

10 DOTS entries:

DT.101980937 DT.99964461 DT.454997 DT.92434686 DT.121290466 DT.121290448 DT.101980938 DT.121290477

DT.313438 DT.95278073

24/208 AceView cDNA sequences (see all 208 ):

AK093287 AW137127 AA809141 AA057839 BG675022 AI568916 CF529435 AA862928

BG621145 AU130876 BM680093 BX648462 AX748033 BU568939 N71793 CB112462

BE208121 BQ024188 AA732354 CB854795 BU618422 CA945025 AW169670 AI624096

highest scoring ESTs for IDE:

M21188 AL526090 AA151146 AA334139 AA573292 AA707082 AI017759 AI076258 AI241500 AI394289

Unigene Cluster for IDE:

Insulin-degrading enzyme

Hs.500546 [show with all ESTs]

Unigene Representative Sequence: BX648462

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IDE

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:																											-										-
SP2:																																			-
SP3:

ExUns:	27	^	28	^	29a	·	29b
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for IDE

2 Ensembl transcripts including schematic representations:

ENST00000265986 ENST00000371581

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDE expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDE

¹ / ² / ³

9 probe-sets matching IDE gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
84458_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.09	AA151146	0.60	1.00	0.82	1
44638_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.15	AA573292	0.60	1.00	0.82	1
31840_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.76	M21188	1.00	1.00	1.00	1
217496_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA918442	0.40	1.00	0.76	1
203328_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004969	0.60	1.00	0.82	1
203327_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N22903	0.40	1.00	0.76	1
217496_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203328_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203327_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGACACAGCC

SOURCE GeneReport for Unigene cluster: Hs.500546
Expression variation in blood from EXPOLDB for IDE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDE gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IDE¹	--	insulin-degrading enzyme	94.7(n) 98.59(a)	477768 XM_534963.2 XP_534963.2
chimpanzee (Pan troglodytes)	IDE¹	--	insulin-degrading enzyme	97.74(n) 97.64(a)	450608 XM_001146582.1 XP_001146582.1
cow (Bos taurus)	IDE¹	--	insulin-degrading enzyme	94.41(n) 98.82(a)	523752 NM_001075849.1 NP_001069317.1
rat (Rattus norvegicus)	Ide¹	--	insulin degrading enzyme	89.7(n) 95.49(a)	25700 NM_013159.1 NP_037291.1
mouse (Mus musculus)	Ide^{1, 5}	19 (25.00 cM)⁵	insulin degrading enzyme^{1, 5}	89.04(n)¹ 95.19(a)¹	15925¹ NM_031156.2¹ NP_112419.2¹ AA387094⁵ AA675336⁵ (see all 15)

About this table Species with no ortholog for IDE

ENSEMBL Gene Tree for IDE

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IDE gene

NRD1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/585 NCBI SNPs in IDE are shown (see all 585 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 137)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3758505^1,2	A,C,F,H	94324758(-)	`AATACT/GTGGAC`	1	--	ng3¹		9		EA EU WA NA	2262
	rs4646954^1,2	A,C,F	94323807(+)	`GCTTCG/AAGCCG`	1	--	ut5¹ ese³		2		MN EA	1252
	rs11187039^1,2	C,H	94259792(+)	`TTTAAG/AATGTT`	1	F/L	mis¹ ese³		4		EU EA WA	418
--	rs7099761^1,2	A,C	94325779(+)	`AAGTAA/GCAATT`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs2229708^1,2	F	94229064(-)	`CAGCAG/AAGCTA`	1	K/E	mis¹ ese³		5		MN EU EA WA	446
	rs12356364^1,2	H	94206153(+)	`AGCATC/TTACTG`	1	D/N	mis¹		4		EU EA WA	416
--	rs2229709^1,2	F	94225717(-)	`AAAGGT/GTACAA`	1	G/G	syn¹ ese³		5		MN EU EA WA	458
	rs1832197^1,2	A,C,F,H,O	94288311(+)	`CTCTTG/ACAAAG`	1	--	int¹		20		EA NA EU WA	1832
	rs2149632^1,2	A,C,F,H,O	94222227(+)	`TTTTAT/CAATCT`	1	--	int¹		7		NA EU EA WA	558
	rs1887922^1,2	A,C,F,H,O	94214145(+)	`GAACAT/CGGCTC`	1	--	int¹		7		EU EA WA NA	560

About this table

HapMap Linkage Disequilibrium images for IDE (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146680

10/15 Novoseek disease relationships for IDE gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	77.29	86	10213160 (2), 15277615 (2), 16894402 (2), 16876916 (2) (see all 43)
senile plaques	66.59	8	10213160 (1), 16876916 (1), 17244626 (1), 14517947 (1) (see all 5)
amyloid deposition	52.41	6	12941771 (1), 17047308 (1), 19073193 (1), 15750394 (1)
hyperinsulinemia	36.76	6	12634421 (3), 11306609 (1), 15850385 (1)
hypofunction	36.39	6	12634421 (2), 15850385 (1)
niddm	35.50	15	18621727 (1), 12634421 (1), 2246195 (1), 15850385 (1) (see all 7)
insulin resistance	35.17	10	16380485 (2), 16930758 (1), 16894402 (1), 17026490 (1) (see all 7)
glucose intolerance	30.22	7	12634421 (2), 17051221 (1), 15850385 (1), 16574064 (1)
brain diseases	29.68	1	10213160 (1)
dementia	26.74	12	17192720 (5), 19415148 (3), 18644361 (1)

About this table

Genetic Association Database: IDE
Human Genome Epidemiology Navigator: IDE (64 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

First U.S. Trials of A New Minimally Invasive Surgical Approach to TMR

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/217 PubMed articles for IDE gene (see all 217 ):

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. (PubMed id 2293021)^{1, 2, 3, 4} Affholter J.A.... Roth R.A. (1990)
Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. (PubMed id 15277398)^{1, 3, 6} Gu H.F....Prince J.A. (2004)
High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. (PubMed id 16380485)^{1, 3, 6} Florez J.C....Groop L. (2006)
Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. (PubMed id 15277615)^{1, 3, 6} Bian L....He L. (2004)
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. (PubMed id 15858813)^{1, 3, 6} Nowotny P....Goate A. (2005)
Lack of association between IDE genetic variability and Down's syndrome. (PubMed id 15911128)^{1, 3, 6} Arpino C....Curatolo P. (2005)
Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. (PubMed id 14517947)^{1, 3, 6} Prince J.A....Brookes A.J. (2003)
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. (PubMed id 15024728)^{1, 3, 6} Ertekin-Taner N....Younkin S.G. (2004)
Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease. (PubMed id 15858821)^{1, 3, 6} Feuk L....Brookes A.J. (2005)
Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease. (PubMed id 15088150)^{1, 3, 6} Blomqvist M.E....Prince J.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3416	HGNC: 5381	AceView: IDE	Ensembl:ENSG00000119912	euGenes: HUgn3416
ECgene: IDE	H-InvDB: IDE

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IDE
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IDE:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDE-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDE		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDE		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IDE)
	Search for Antibodies
	Chimera RNAi (IDE)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for IDE

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IDE

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IDE Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for IDE

Summaries
for IDE

Genomic Location
for IDE

Proteins
for IDE

Protein Domains/
Families
for IDE

Gene Function
for IDE

Pathways & Interactions
for IDE

Drugs & Compounds
for IDE

Transcripts
for IDE

Expression
for IDE

Orthologs
for IDE

Paralogs
for IDE

SNPs/Variants
for IDE

Disorders & Mutations
for IDE

Medical News
for IDE

Publications
for IDE

Search for IDE

Genome Databases showing IDE

Other Databases showing IDE

Specialized Databases showing IDE

Licensable Technologies
for IDE

Services
for IDE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDE Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor IDE

Summariesfor IDE

Genomic Locationfor IDE

Proteinsfor IDE

Protein Domains/Familiesfor IDE

Gene Functionfor IDE

Pathways & Interactionsfor IDE

Drugs & Compoundsfor IDE

Transcriptsfor IDE

Expression for IDE

Orthologsfor IDE

Paralogsfor IDE

SNPs/Variantsfor IDE

Disorders & Mutationsfor IDE

Medical Newsfor IDE

Publicationsfor IDE

Search for IDE

Genome Databases showing IDE

Other Databases showing IDE

Specialized Databases showing IDE

Licensable Technologiesfor IDE

Servicesfor IDE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDE

Summaries
for IDE

Genomic Location
for IDE

Proteins
for IDE

Protein Domains/
Families
for IDE

Gene Function
for IDE

Pathways & Interactions
for IDE

Drugs & Compounds
for IDE

Transcripts
for IDE

Expression
for IDE

Orthologs
for IDE

Paralogs
for IDE

SNPs/Variants
for IDE

Disorders & Mutations
for IDE

Medical News
for IDE

Publications
for IDE

Licensable Technologies
for IDE

Services
for IDE