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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ID4 Gene

protein-coding GIFtS: 57
GCID: GC06P019837

inhibitor of DNA binding 4, dominant negative helix-loop-helix...

Explore 26 diseases affiliated with
ID4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein¹ ²		DNA-Binding Protein Inhibitor ID-4²
BHLHb27¹		BHLHB27³
Class B Basic Helix-Loop-Helix Protein 27² ³		Inhibitor Of DNA Binding 4³
IDB4²

External Ids:	HGNC: 5363¹	Entrez Gene: 3400²	Ensembl: ENSG00000172201⁷	OMIM: 600581⁵	UniProtKB: P47928³

Export aliases for ID4 gene to outside databases

Previous GC identifers: GC06P019895 GC06P019945 GC06P019782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ID4:

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic

helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently,

the activity of the encoded protein depends on the protein binding partner. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers

with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ID4 gene promoter:
SRF LHX3b/Lhx3b SRF (504 AA) MyoD LCR-F1 CREB Pax-3 POU2F1a LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ID4 promoter sequence

Search SABiosciences Chromatin IP Primers for ID4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ID4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3

ID4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID4 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P019837: view genomic region (about GC identifiers)

Start:	19,837,617 bp from pter	End:	19,840,915 bp from pter
Size:	3,299 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928 (See protein sequence)

Recommended Name: DNA-binding protein inhibitor ID-4

Size: 161 amino acids; 16622 Da

Subunit: Heterodimer with other HLH proteins

Subcellular location: Nucleus

Secondary accessions: Q13005

Explore the universe of human proteins at neXtProt for ID4: NX_P47928

ID4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001537.1

ENSEMBL proteins:

ENSP00000367972

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals ID4 Proteins Novus Biologicals ID4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ID4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	11136250
GO:0005737	cytoplasm	IEA	--

ID4 for ontologies About GeneDecksing

ID4 Antibody Products:

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	Uscn Antibodies for ID4
	ThermoFisher Antibody for ID4

Assay Products for ID4:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for ID4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ID4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ID4 for domains About GeneDecksing

2 InterPro domains/families:

IPR026052 DNA-bd_prot-inh

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry P47928

ProtoNet protein and cluster: P47928

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers

with other HLH proteins, thereby inhibiting DNA binding

Genatlas biochemistry entry for ID4:

inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly expressed

in thyroid,brain and fetal tissue and in some nervous system tumor cell lines

miRNA Products:		OriGene 3'-UTR Clone: ID4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID4
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ID4 (see all 43):
		hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: ID4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID4 (see all 7) OriGene shRNA RFP: ID4 OriGene siRNA: ID4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ID4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ID4
		Search LifeMap BioReagents cell lines for ID4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001085	RNA polymerase II transcription factor binding	IEA	--
GO:0003714	transcription corepressor activity	TAS	7665172
GO:0005515	protein binding	IPI	17474147
GO:0046983	protein dimerization activity	IEA	--

ID4 for ontologies About GeneDecksing

Animal Models:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Id4):

adipose tissue	behavior/neurological	cellular	growth/size	mortality/aging
nervous system	skeleton

ID4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Id Signaling Pathway

Id Signaling Pathway

1.00

TGF-beta signaling pathway

TGF-beta signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ID4

Id Signaling Pathway

1 Kegg Pathway (Kegg details for ID4):

TGF-beta signaling pathway

ID4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ID4

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/18 Interacting proteins for ID4 (P47928^{1, 2, 3} ENSP00000367972⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8112039 I2D: score=3 STRING: ENSP00000274335
PLCG1	P19174²^,³, ENSP00000244007⁴	MINT-8112591 I2D: score=3 STRING: ENSP00000244007
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1754719,EBI-3448658 I2D: score=2 STRING: ENSP00000288986
SRC	P12931²^,³, ENSP00000350941⁴	MINT-8113119 I2D: score=3 STRING: ENSP00000350941
CRK	P46108³, ENSP00000300574⁴	I2D: score=2 STRING: ENSP00000300574

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	7665172
GO:0007405	neuroblast proliferation	IEA	--
GO:0007420	brain development	--	--

ID4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ID4
Search CenterWatch for drugs/clinical trials and news about ID4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ID4 gene:

NM_001546.3

Unigene Clusters for ID4:

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Hs.519601 [show with all ESTs], Hs.731649 [show with all ESTs]

Unigene Representative Sequences: NM_001546, AJ420553

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000378700(uc003ncw.3)

miRNA Products:		OriGene 3'-UTR Clone: ID4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID4
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ID4 (see all 43):
		hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: ID4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID4 (see all 7) OriGene shRNA RFP: ID4 OriGene siRNA: ID4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ID4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ID4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID4

Additional cDNA sequence:

AJ420553.1 AK130851.1

5 DOTS entries:

DT.115783 DT.75101421 DT.121344012 DT.87002090 DT.443817

24/358 AceView cDNA sequences (see all 358):

BM800167 AI202319 CF890826 AW451803 BF940116 AI474274 BF434998 AW119000

AI371032 AI268332 BF514498 BM127816 AW028722 BM473615 BE551065 AA483691

CB241088 BE219820 AI469058 AV646822 BM128092 AI268743 AA394164 AI383225

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ID4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAATATTAA

About this image

ID4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatogonial Stem Cells

Selective marker (cell-identifying gene)

Germ Cells, Male Gametocytes

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Brain

Brain

Kidney

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

N2/LSB induced-cells (Generation of midbra...)

Primitive gut tube-like cells (A scalable, suspensi...)

See ID4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ID4

SOURCE GeneReport for Unigene clusters: Hs.519601 Hs.731649

SABiosciences Expression via Pathway-Focused PCR Arrays including ID4:

Notch Signaling Targets in human mouse rat

Lymphoma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ID4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ID4
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ID4 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ID4⁶	inhibitor of DNA binding 4, dominant negative heli...	87(a)	1 ↔ 1	2(60842179-60843358)
lizard (Anolis carolinensis)	Reptilia	ID4⁶	--	76(a)	1 ↔ 1	4(56135591-56135893)
African clawed frog (Xenopus laevis)	Amphibia	idb4-prov²	inhibitor of DNA binding 4	78.11(n)		BC045022.1
zebrafish (Danio rerio)	Actinopterygii	id4¹	inhibitor of DNA binding 4	66.13(n) 69.6(a)		664761 NM_001039990.1 NP_001035079.1

ENSEMBL Gene Tree for ID4 (if available)
TreeFam Gene Tree for ID4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ID4 gene

ID1² ID3² ID2²

3 SIMAP similar genes for ID4 using alignment to 1 protein entry: ID4_HUMAN:

ID2 ID1 ID3

ID4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114605388^1,2	F,	--	19835631(+)	`ATCAAT/CGGAAC`	1	--	us2k¹		1		NA	120
rs182268397^1,2		--	19835696(+)	`CTCCAA/GGATAA`	1	--	us2k¹		0	--	--	--	--
rs149097564^1,2		--	19835781(+)	`ATTTAA/GTGATG`	1	--	us2k¹		0	--	--	--	--
rs142214754^1,2		--	19835797(+)	`GACTAC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs55907705^1,2	F,	--	19835915(+)	`CAAACA/CATTAT`	1	--	us2k¹		1		NA	120
rs185917167^1,2		--	19835948(+)	`TTAGGG/TGAGAG`	1	--	us2k¹		0	--	--	--	--
rs115886092^1,2	F,	--	19835967(+)	`TTGCAT/GCTACC`	1	--	us2k¹		1		WA	118
rs6919858^1,2	C,F,A,H,	--	19836015(+)	`CAGGAG/AAAAGG`	1	--	us2k¹ trp³		9		NA WA CSA EA	370
rs146766234^1,2		--	19836096(+)	`AGGTAA/TTTCAG`	1	--	us2k¹		0	--	--	--	--
rs140223063^1,2		--	19836117(+)	`GGATGC/TAGAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ID4 (19837617 - 19840915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ID4
3 CNVs: 5038 93530 69346
1 Indel: 59313

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ID4

DNA2.0 Custom Variant and Variant Library Synthesis for ID4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ID4 for disorders           About GeneDecksing

OMIM gene information: 600581    OMIM disorders: --

20/26 diseases for ID4 (see all 26):    About MalaCards

oligoastrocytoma lymphoblastic leukemia myeloid leukemia alcohol dependence

acute lymphoblastic leukemia chronic myeloid leukemia acute myeloid leukemia rett syndrome

acute leukemia leukemia multiple myeloma myelodysplastic syndrome

oligodendroglioma gastric adenocarcinoma prostate cancer myeloma

alcoholism thyroid cancer thyroiditis lung cancer

9 Novoseek disease relationships for ID4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	32.5	3	12969807 (1), 17074115 (1), 18928580 (1)
acute leukemia	23.2	1	17074115 (3), 18088456 (2)
leukemia	17.3	10	17074115 (3), 19379587 (2), 12969807 (1), 19099656 (1)
primary tumor	9.31	1	16867866 (1)
prostate cancer	8.42	7	19500415 (6), 16106424 (1)
tumors	6.06	14	19500415 (3), 16867866 (2), 14633621 (2), 16018821 (2) (see all 5)
metastasis	0	2	20388805 (1), 16867866 (1)
carcinoma	0	12	16867866 (7), 14633621 (4)
cancer	0	5	19500415 (2), 16106424 (1)

Human Genome Epidemiology (HuGE) Navigator: ID4 (4 documents)

Export disorders for ID4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ID4 gene, integrated from 9 sources (see all 78):
(articles sorted by number of sources associating them with ID4)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PubMed id 7665172)^{1, 2, 3, 9} Pagliuca A.... Lania L. (1995)
cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PubMed id 9872455)^{1, 2, 9} Rigolet M.... Junien C. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. (PubMed id 14633621)^{1, 9} Shan L....Snyderwine E.G. (2003)
[Preliminary Study on Id4 as A Reporter for ALL Patients before Relapse.] (PubMed id 18928580)^{1, 9} Zhao Y....Yu L. (2008)
Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. (PubMed id 12969807)^{1, 9} Bellido M....Nomdedeu J.F. (2003)
[Preliminary study on difference of Id4 gene methylat ion in various types of myelodysplastic syndromes] (PubMed id 19549375)^{1, 9} Zhao Y....Yu L. (2009)
Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. (PubMed id 11136250)^{1, 9} Beger C....Wong-Staal F. (2001)
[Methylation of Id4 gene promoter in acute leukemia] (PubMed id 18088456)^{1, 9} Zhao Y....Yu L. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3400	HGNC: 5363	AceView: ID4	Ensembl:ENSG00000172201	euGenes: HUgn3400
ECgene: ID4	Kegg: 3400	H-InvDB: ID4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ID4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ID4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ID4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ID4 gene:
Search GeneIP for patents involving ID4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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