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Aliases for ID4 Gene

Aliases for ID4 Gene

  • Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 27 3 4
  • Inhibitor Of Differentiation 4 3 4
  • BHLHb27 3 4
  • DNA-Binding Protein Inhibitor ID-4 3
  • Inhibitor Of DNA Binding 4 4
  • IDB4 3

External Ids for ID4 Gene

Previous GeneCards Identifiers for ID4 Gene

  • GC06P019895
  • GC06P019945
  • GC06P019782

Summaries for ID4 Gene

Entrez Gene Summary for ID4 Gene

  • This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]

GeneCards Summary for ID4 Gene

ID4 (Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein) is a Protein Coding gene. Diseases associated with ID4 include oligoastrocytoma and acute leukemia. Among its related pathways are TGF-beta signaling pathway (KEGG) and Id Signaling Pathway. GO annotations related to this gene include transcription corepressor activity and RNA polymerase II transcription factor binding. An important paralog of this gene is ID3.

UniProtKB/Swiss-Prot for ID4 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

Gene Wiki entry for ID4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID4 Gene

Genomics for ID4 Gene

Regulatory Elements for ID4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ID4 Gene

Start:
19,837,348 bp from pter
End:
19,842,200 bp from pter
Size:
4,853 bases
Orientation:
Plus strand

Genomic View for ID4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ID4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID4 Gene

Proteins for ID4 Gene

  • Protein details for ID4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47928-ID4_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-4
    Protein Accession:
    P47928
    Secondary Accessions:
    • Q13005

    Protein attributes for ID4 Gene

    Size:
    161 amino acids
    Molecular mass:
    16622 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins

neXtProt entry for ID4 Gene

Proteomics data for ID4 Gene at MOPED

Post-translational modifications for ID4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ID4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID4 Gene

Domains for ID4 Gene

Gene Families for ID4 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for ID4 Gene

Suggested Antigen Peptide Sequences for ID4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47928

UniProtKB/Swiss-Prot:

ID4_HUMAN :
  • P47928
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ID4: view

Function for ID4 Gene

Molecular function for ID4 Gene

GENATLAS Biochemistry: inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly expressed in thyroid,brain and fetal tissue and in some nervous system tumor cell lines
UniProtKB/Swiss-Prot Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

Gene Ontology (GO) - Molecular Function for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0003714 transcription corepressor activity TAS 7665172
GO:0005515 protein binding IPI 17474147
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ID4: view
genes like me logo Genes that share phenotypes with ID4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ID4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ID4 Gene

Localization for ID4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ID4 Gene COMPARTMENTS Subcellular localization image for ID4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 11136250
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ID4: view

Pathways for ID4 Gene

genes like me logo Genes that share pathways with ID4: view

Pathways by source for ID4 Gene

1 BioSystems pathway for ID4 Gene
1 KEGG pathway for ID4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7665172
GO:0007405 neuroblast proliferation IEA --
genes like me logo Genes that share ontologies with ID4: view

Transcripts for ID4 Gene

mRNA/cDNA for ID4 Gene

(358) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ID4 Gene

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ID4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ID4 Gene

No ASD Table

Relevant External Links for ID4 Gene

GeneLoc Exon Structure for
ID4
ECgene alternative splicing isoforms for
ID4

Expression for ID4 Gene

mRNA expression in normal human tissues for ID4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID4 Gene

This gene is overexpressed in Artery - Coronary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ID4 Gene

SOURCE GeneReport for Unigene cluster for ID4 Gene Hs.519601

genes like me logo Genes that share expressions with ID4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ID4 Gene

Orthologs for ID4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ID4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Id4 35
  • 93.17 (n)
  • 98.14 (a)
Id4 16
Id4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ID4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID4 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Id4 35
  • 92.96 (n)
  • 95.65 (a)
chicken
(Gallus gallus)
Aves ID1 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ID4 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia idb4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia id4 35
  • 73.08 (n)
  • 76.15 (a)
Str.5460 35
zebrafish
(Danio rerio)
Actinopterygii id4 35
  • 66.67 (n)
  • 67.2 (a)
id4 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta emc 36
  • 7 (a)
OneToMany
Species with no ortholog for ID4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID4 Gene

ENSEMBL:
Gene Tree for ID4 (if available)
TreeFam:
Gene Tree for ID4 (if available)

Paralogs for ID4 Gene

Paralogs for ID4 Gene

Selected SIMAP similar genes for ID4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ID4: view

Variants for ID4 Gene

Sequence variations from dbSNP and Humsavar for ID4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2819 -- 19,839,364(+) AAAAA(A/T)ACAAC utr-variant-3-prime
rs8214 -- 19,839,548(+) AGAAG(C/G/T)CTACT utr-variant-3-prime
rs140710 -- 19,836,637(-) AGAAG(-/AAG)GAAAA upstream-variant-2KB
rs719346 -- 19,841,723(-) TGCAT(A/G)TAATT utr-variant-3-prime
rs926368 -- 19,837,317(-) gcggg(A/G)ccagc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ID4 Gene

Variant ID Type Subtype PubMed ID
nsv883465 CNV Loss 21882294
esv23665 CNV Loss 19812545
nsv819869 CNV Gain 19587683

Relevant External Links for ID4 Gene

HapMap Linkage Disequilibrium report
ID4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID4 Gene

Disorders for ID4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ID4 Gene including...

Search for ID4 Gene in MalaCards »

(9) Novoseek inferred disease relationships for ID4 Gene

Disease -log(P) Hits PubMed IDs
lymphoblastic leukemia acute 32.5 3
acute leukemia 23.2 5
leukemia 17.3 7
primary tumor 9.31 1
prostate cancer 8.42 7

Relevant External Links for ID4

Genetic Association Database (GAD)
ID4
Human Genome Epidemiology (HuGE) Navigator
ID4
genes like me logo Genes that share disorders with ID4: view

No data available for UniProtKB/Swiss-Prot for ID4 Gene

Publications for ID4 Gene

  1. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PMID: 7665172) Pagliuca A. … Lania L. (Genomics 1995) 2 3 4 23
  2. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PMID: 9872455) Rigolet M. … Junien C. (DNA Res. 1998) 3 4 23
  3. Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. (PMID: 9418957) Stewart H.J. … Jessen K.R. (J. Neurosci. Res. 1997) 3 23
  4. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. (PMID: 11136250) Beger C. … Wong-Staal F. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  5. Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. (PMID: 12969807) Bellido M. … NomdedAcu J.F. (Haematologica 2003) 3 23

Products for ID4 Gene

Sources for ID4 Gene

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