Aliases for ID4 Gene
External Ids for ID4 Gene
Previous GeneCards Identifiers for ID4 Gene
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]
GeneCards Summary for ID4 Gene
ID4 (Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein) is a Protein Coding gene. Diseases associated with ID4 include oligoastrocytoma and acute leukemia. Among its related pathways are TGF-beta signaling pathway (KEGG) and Id Signaling Pathway. GO annotations related to this gene include transcription corepressor activity and RNA polymerase II transcription factor binding. An important paralog of this gene is ID3.
UniProtKB/Swiss-Prot for ID4 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).