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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ID4 Gene

protein-coding   GIFtS: 58
GCID: GC06P019837

Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix
Protein1 2
     DNA-Binding Protein Inhibitor ID-42
Class B Basic Helix-Loop-Helix Protein 272 3     BHLHB273
bHLHb272 3     Inhibitor Of DNA Binding 43
IDB42     

External Ids:    HGNC: 53631   Entrez Gene: 34002   Ensembl: ENSG000001722017   OMIM: 6005815   UniProtKB: P479283   

Export aliases for ID4 gene to outside databases

Previous GC identifers: GC06P019895 GC06P019945 GC06P019782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ID4 Gene:
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic
helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity.
Consequently, the activity of the encoded protein depends on the protein binding partner. (provided by RefSeq,
Dec 2011)

GeneCards Summary for ID4 Gene: 
ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein) is a protein-coding gene. Diseases associated with ID4 include oligoastrocytoma, and acute leukemia. GO annotations related to this gene include RNA polymerase II transcription factor binding and transcription corepressor activity. An important paralog of this gene is ID1.

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ID4 gene promoter:
         SRF   LHX3b/Lhx3b   SRF (504 AA)   MyoD   LCR-F1   CREB   Pax-3   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidID4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ID4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ID4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

ID4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P019837:  view genomic region     (about GC identifiers)

Start:
19,837,617 bp from pter      End:
19,840,915 bp from pter
Size:
3,299 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-4  
Size: 161 amino acids; 16622 Da
Subunit: Heterodimer with other HLH proteins
Subcellular location: Nucleus
Secondary accessions: Q13005

Explore the universe of human proteins at neXtProt for ID4: NX_P47928

Explore proteomics data for ID4 at MOPED 

ID4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ID4 Protein Expression

REFSEQ proteins: NP_001537.1  
ENSEMBL proteins: 
 ENSP00000367972  

Human Recombinant Protein Products for ID4: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for ID4
OriGene Protein Over-expression Lysate for ID4
OriGene MassSpec for ID4 
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Novus Biologicals ID4 Proteins
Novus Biologicals ID4 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for ID4 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC11136250
GO:0005737cytoplasm IEA--

ID4 for ontologies           About GeneDecksing



ID4 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of ID4
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GenScript Custom Superior Antibodies Services for ID4
Novus Biologicals ID4 Antibodies
Abcam antibodies for ID4
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ThermoFisher Antibody for ID4
LSBio Antibodies in human, mouse, rat for ID4 

Assay Products for ID4: 
Browse Kits and Assays available from EMD Millipore
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ID4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for ID4 
Cloud-Clone Corp. CLIAs for ID4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
bHLH: Basic helix-loop-helix proteins

2 InterPro protein domains:
 IPR026052 DNA-bd_prot-inh
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry P47928

ProtoNet protein and cluster: P47928

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


ID4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ID4_HUMAN, P47928
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding

     Genatlas biochemistry entry for ID4:
inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly
expressed in thyroid,brain and fetal tissue and in some nervous system tumor cell lines

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001085RNA polymerase II transcription factor binding IEA--
GO:0003714transcription corepressor activity TAS7665172
GO:0005515protein binding IPI17474147
GO:0046983protein dimerization activity IEA--
     
ID4 for ontologies           About GeneDecksing


Phenotypes:
     7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Id4):
 adipose tissue  behavior/neurological  cellular  growth/size  mortality/aging 
 nervous system  skeleton 

ID4 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ID4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ID4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ID4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ID4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID4
8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ID4 (see all 43):
hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidID4 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ID4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ID4
Sirion Biotech Customized adenovirus for overexpression of ID4

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for ID4 (see all 7)
OriGene ORF clones in mouse, rat for ID4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4
Sirion Biotech Customized lentivirus for stable overexpression of ID4 
                     Customized lentivirus expression plasmids for stable overexpression of ID4 

Cell Line
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GenScript Custom overexpressing Cell Line Services for ID4
Search LifeMap BioReagents cell lines for ID4
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ID4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Id Signaling Pathway
Id Signaling Pathway
2Hippo signaling pathway
Hippo signaling pathway
3TGF-beta signaling pathway
TGF-beta signaling pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ID4
    Id Signaling Pathway


2         Kegg Pathways  (Kegg details for ID4):
    TGF-beta signaling pathway
Hippo signaling pathway


ID4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ID4

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/18 Interacting proteins for ID4 (P479281, 2, 3 ENSP000003679724) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
PIK3R1P279862, 3, ENSP000002743354MINT-8112039 I2D: score=3 STRING: ENSP00000274335
PLCG1P191742, 3, ENSP000002440074MINT-8112591 I2D: score=3 STRING: ENSP00000244007
NCK1P163331, 3, ENSP000002889864EBI-1754719,EBI-389883 I2D: score=2 STRING: ENSP00000288986
SRCP129312, 3, ENSP000003509414MINT-8113119 I2D: score=3 STRING: ENSP00000350941
CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000082G1/S transition of mitotic cell cycle IEA--
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006357regulation of transcription from RNA polymerase II promoter TAS7665172
GO:0007405neuroblast proliferation IEA--
GO:0007420brain development ----

ID4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ID4

Search CenterWatch for drugs/clinical trials and news about ID4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ID4 gene: 
NM_001546.3  

Unigene Clusters for ID4:

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Hs.519601  [show with all ESTs], Hs.663469  [show with all ESTs]
Unigene Representative Sequences: NM_001546, AJ420553
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000378700(uc003ncw.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID4
8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ID4 (see all 43):
hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidID4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ID4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID4
Clone
Products:
     
OriGene clones in human, mouse for ID4 (see all 7)
OriGene ORF clones in mouse, rat for ID4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4
Sirion Biotech Customized lentivirus for stable overexpression of ID4 
                     Customized lentivirus expression plasmids for stable overexpression of ID4 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ID4
OriGene qSTAR qPCR primer pairs in human, mouse for ID4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ID4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID4

Additional mRNA sequence: 

AJ420553.1 AK130851.1 

5 DOTS entries:

DT.115783  DT.75101421  DT.87002090  DT.121344012  DT.443817 

24/358 AceView cDNA sequences (see all 358):

AA513037 AI474274 AA371177 AW119000 AI205651 AA972772 AA405766 AI076496 
AI671882 AI858674 BM982748 AI268332 BC014941 BF514961 BE671351 BM800167 
BI966861 AI417870 BE467572 AI299481 AA923038 AW028722 BE219820 AI377829 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ID4 expression in normal human tissues (normalized intensities)      ID4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAATATTAA
ID4 Expression
About this image


ID4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/13 selected tissues (see all 13) fully expand
 
 Brain (Nervous System)    fully expand to see all 23 entries
         Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
         Thalamus
         Septum   
 
 Spinal Cord (Nervous System)    fully expand to see all 4 entries
         Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
         Dorsal Horn   
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
 
 Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
         visceral organ/urogenital sinus/nerves of urogenital sinus   
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         GABAergic Amacrine Cells Inner Nuclear Layer

See ID4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ID4

SOURCE GeneReport for Unigene clusters: Hs.519601 Hs.663469
    SABiosciences Expression via Pathway-Focused PCR Arrays including ID4: 
          Notch Signaling Targets in human mouse rat
          Lymphoma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for ID4
OriGene qSTAR qPCR primer pairs in human, mouse for ID4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ID4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ID4 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Id41 , 5 inhibitor of DNA binding 41, 5 93.17(n)1
98.14(a)1
  13 (24.71 cM)5
159041  NM_031166.21  NP_112443.11 
 482614275 
chicken
(Gallus gallus)
Aves ID16
DNA-binding protein inhibitor ID-1
38(a)
possible ortholog
20(10351641-10352379)
lizard
(Anolis carolinensis)
Reptilia ID46
Uncharacterized protein
74(a)
1 ↔ 1
4(56135591-56135893)
African clawed frog
(Xenopus laevis)
Amphibia idb4-prov2 inhibitor of DNA binding 4 78.11(n)    BC045022.1 
zebrafish
(Danio rerio)
Actinopterygii id41 inhibitor of DNA binding 4 66.13(n)
69.6(a)
  664761  NM_001039990.1  NP_001035079.1 
fruit fly
(Drosophila melanogaster)
Insecta emc6
extra macrochaetae
16(a)
1 → many
3L(749400-753492)


ENSEMBL Gene Tree for ID4 (if available)
TreeFam Gene Tree for ID4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ID4 gene
ID12  ID22  ID32  
3 SIMAP similar genes for ID4 using alignment to 1 protein entry:     ID4_HUMAN:
ID2    ID1    ID3

ID4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/212 SNPs in ID4 are shown (see all 212)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1146053881,2
C,F--19835631(+) ATCAAT/CGGAAC 1 -- us2k11Minor allele frequency- C:0.03NA 120
rs1822683971,2
--19835696(+) CTCCAA/GGATAA 1 -- us2k10--------
rs1490975641,2
--19835781(+) ATTTAA/GTGATG 1 -- us2k10--------
rs1422147541,2
--19835797(+) GACTAC/TGCCTG 1 -- us2k10--------
rs559077051,2
C,F--19835915(+) CAAACA/CATTAT 1 -- us2k11Minor allele frequency- C:0.05NA 120
rs1859171671,2
--19835948(+) TTAGGG/TGAGAG 1 -- us2k10--------
rs1158860921,2
C,F--19835967(+) TTGCAT/GCTACC 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs69198581,2
C,F,A,H--19836015(+) CAGGAG/AAAAGG 1 -- us2k1 trp39Minor allele frequency- A:0.46NA WA CSA EA 370
rs1467662341,2
C--19836096(+) AGGTAA/TTTCAG 1 -- us2k10--------
rs1402230631,2
--19836117(+) GGATGC/TAGAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ID4 (19837617 - 19840915 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ID4:    About this table     
Variant IDTypeSubtypePubMed ID
esv23665CNV Loss19812545
nsv883465CNV Loss21882294
nsv819869CNV Gain19587683

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ID4
DNA2.0 Custom Variant and Variant Library Synthesis for ID4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600581    OMIM disorders: --

20/26 diseases for ID4 (see all 26):    About MalaCards
oligoastrocytoma    acute leukemia    rett syndrome    gastric adenocarcinoma
chronic myeloid leukemia    alcohol dependence    oligodendroglioma    lymphoblastic leukemia
acute myeloid leukemia    thyroid cancer    acute lymphoblastic leukemia    myelodysplastic syndromes
myeloid leukemia    multiple myeloma    alcoholism    myeloma
prostate cancer    leukemia    thyroiditis    cerebritis


ID4 for disorders           About GeneDecksing

9 Novoseek inferred disease relationships for ID4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute 32.5 3 12969807 (1), 17074115 (1), 18928580 (1)
acute leukemia 23.2 1 17074115 (3), 18088456 (2)
leukemia 17.3 10 17074115 (3), 19379587 (2), 12969807 (1), 19099656 (1)
primary tumor 9.31 1 16867866 (1)
prostate cancer 8.42 7 19500415 (6), 16106424 (1)
tumors 6.06 14 19500415 (3), 16867866 (2), 14633621 (2), 16018821 (2) (see all 5)
metastasis 0 2 20388805 (1), 16867866 (1)
carcinoma 0 12 16867866 (7), 14633621 (4)
cancer 0 5 19500415 (2), 16106424 (1)

Genetic Association Database (GAD): ID4
Human Genome Epidemiology (HuGE) Navigator: ID4 (4 documents)

Export disorders for ID4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ID4 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with ID4)
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  1. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PubMed id 7665172)1, 2, 3, 9 Pagliuca A.... Lania L. (1995)
  2. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PubMed id 9872455)1, 2, 9 Rigolet M.... Junien C. (1998)
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  6. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. (PubMed id 14633621)1, 9 Shan L....Snyderwine E.G. (2003)
  7. [Preliminary Study on Id4 as A Reporter for ALL Patients before Relapse.] (PubMed id 18928580)1, 9 Zhao Y....Yu L. (2008)
  8. Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. (PubMed id 12969807)1, 9 Bellido M....Nomdedeu J.F. (2003)
  9. [Preliminary study on difference of Id4 gene methylat ion in various types of myelodysplastic syndromes] (PubMed id 19549375)1, 9 Zhao Y....Yu L. (2009)
  10. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. (PubMed id 11136250)1, 9 Beger C....Wong-Staal F. (2001)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3400 HGNC: 5363 AceView: ID4 Ensembl:ENSG00000172201 euGenes: HUgn3400
ECgene: ID4 Kegg: 3400 H-InvDB: ID4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ID4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ID4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
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Patent Information for ID4 gene:
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