Aliases for ID4 Gene
External Ids for ID4 Gene
Previous GeneCards Identifiers for ID4 Gene
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]
GeneCards Summary for ID4 Gene
ID4 (Inhibitor Of DNA Binding 4, HLH Protein) is a Protein Coding gene. Diseases associated with ID4 include mesomelic dysplasia savarirayan type. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and TGF-beta signaling pathway (KEGG). GO annotations related to this gene include protein dimerization activity and RNA polymerase II transcription factor binding. An important paralog of this gene is ID3.
UniProtKB/Swiss-Prot for ID4 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).