Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ID4 Gene

protein-coding   GIFtS: 58
GCID: GC06P019837

Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix...

  See ID4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix
Protein1 2
     DNA-Binding Protein Inhibitor ID-42
Class B Basic Helix-Loop-Helix Protein 272 3     BHLHB273
bHLHb272 3     Inhibitor Of DNA Binding 43
IDB42     

External Ids:    HGNC: 53631   Entrez Gene: 34002   Ensembl: ENSG000001722017   OMIM: 6005815   UniProtKB: P479283   

Export aliases for ID4 gene to outside databases

Previous GC identifers: GC06P019895 GC06P019945 GC06P019782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ID4 Gene:
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic
helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity.
Consequently, the activity of the encoded protein depends on the protein binding partner. (provided by RefSeq,
Dec 2011)

GeneCards Summary for ID4 Gene:
ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein) is a protein-coding gene. Diseases associated with ID4 include oligoastrocytoma, and acute leukemia. GO annotations related to this gene include RNA polymerase II transcription factor binding and transcription corepressor activity. An important paralog of this gene is ID1.

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ID4 gene promoter:
         SRF   LHX3b/Lhx3b   SRF (504 AA)   MyoD   LCR-F1   CREB   Pax-3   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidID4 promoter sequence
   Search Chromatin IP Primers for ID4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ID4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

ID4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P019837:  view genomic region     (about GC identifiers)

Start:
19,837,617 bp from pter      End:
19,840,915 bp from pter
Size:
3,299 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-4  
Size: 161 amino acids; 16622 Da
Subunit: Heterodimer with other HLH proteins
Secondary accessions: Q13005

Explore the universe of human proteins at neXtProt for ID4: NX_P47928

Explore proteomics data for ID4 at MOPED


See ID4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001537.1  
ENSEMBL proteins: 
 ENSP00000367972  

ID4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for ID4
OriGene Protein Over-expression Lysate for ID4
OriGene MassSpec for ID4
OriGene Custom Protein Services for ID4
GenScript Custom Purified and Recombinant Proteins Services for ID4
Novus Biologicals ID4 Proteins
Novus Biologicals ID4 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for ID4

 
Search eBioscience for Proteins for ID4 

 
antibodies-online proteins for ID4 (7 products) 

 
antibodies-online peptides for ID4

ID4 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of ID4
Browse R&D Systems for Antibodies
OriGene Antibodies for ID4
OriGene Custom Antibody Services for ID4
Novus Biologicals ID4 Antibodies
Abcam antibodies for ID4
Cloud-Clone Corp. Antibodies for ID4
ThermoFisher Antibody for ID4
antibodies-online antibodies for ID4 (48 products) 

ID4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for ID4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ID4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for ID4
Cloud-Clone Corp. CLIAs for ID4
Search eBioscience for ELISAs for ID4 
antibodies-online kits for ID4 (7 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

2 InterPro protein domains:
 IPR026052 DNA-bd_prot-inh
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry P47928

ProtoNet protein and cluster: P47928

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ID4_HUMAN, P47928
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


Find genes that share domains with ID4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ID4_HUMAN, P47928
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding

     Genatlas biochemistry entry for ID4:
inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly
expressed in thyroid,brain and fetal tissue and in some nervous system tumor cell lines

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001085RNA polymerase II transcription factor binding IEA--
GO:0003714transcription corepressor activity TAS7665172
GO:0005515protein binding IPI17474147
GO:0046983protein dimerization activity IEA--
     
Find genes that share ontologies with ID4           About GenesLikeMe


Phenotypes:
     7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Id4):
 adipose tissue  behavior/neurological  cellular  growth/size/body  mortality/aging 
 nervous system  skeleton 

Find genes that share phenotypes with ID4           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ID4

miRNA
Products:
    
miRTarBase miRNAs that target ID4:
hsa-mir-324-3p (MIRT042873), hsa-mir-340-5p (MIRT019630), hsa-mir-192-5p (MIRT026740), hsa-mir-9-5p (MIRT021484), hsa-mir-590-3p (MIRT016169), hsa-mir-186-5p (MIRT045037), hsa-mir-27a-3p (MIRT028697), hsa-mir-124-3p (MIRT022878), hsa-mir-335-5p (MIRT018452)

Block miRNA regulation of human, mouse, rat ID4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ID4 (see all 43):
hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidID4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ID4
Predesigned siRNA for gene silencing in human, mouse, rat ID4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ID4

Clone
Products:
     
OriGene clones in human, mouse for ID4 (see all 6)
OriGene ORF clones in mouse, rat for ID4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for ID4
Browse ESI BIO Cell Lines and PureStem Progenitors for ID4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
ID4_HUMAN, P47928: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC11136250
GO:0005737cytoplasm IEA--

Find genes that share ontologies with ID4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for ID4 About    
See pathways by source

SuperPathContained pathways About
1TGF-beta signaling pathway (KEGG)
TGF-beta signaling pathway
2Id Signaling Pathway
Id Signaling Pathway


Find genes that share SuperPaths with ID4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ID4
    Id Signaling Pathway


1 Kegg Pathway  (Kegg details for ID4):
    TGF-beta signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including ID4: 
          Notch Signaling Targets in human mouse rat
          Lymphoma in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for ID4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ID4 (P479281, 2, 3 ENSP000003679724) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
InteractantInteraction Details
GeneCardExternal ID(s)
PIK3R1P279862, 3, ENSP000002743354MINT-8112039 I2D: score=3 STRING: ENSP00000274335
PLCG1P191742, 3, ENSP000002440074MINT-8112591 I2D: score=3 STRING: ENSP00000244007
NCK1P163331, 3, ENSP000002889864EBI-1754719,EBI-389883 I2D: score=2 STRING: ENSP00000288986
SRCP129312, 3, ENSP000003509414MINT-8113119 I2D: score=3 STRING: ENSP00000350941
CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
About this table

Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000082G1/S transition of mitotic cell cycle IEA--
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006357regulation of transcription from RNA polymerase II promoter TAS7665172
GO:0007405neuroblast proliferation IEA--
GO:0007420brain development ----

Find genes that share ontologies with ID4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ID4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for ID4 gene: 
NM_001546.3  

Unigene Clusters for ID4:

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Hs.519601  [show with all ESTs], Hs.663469  [show with all ESTs]
Unigene Representative Sequences: NM_001546, AJ420553
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000378700(uc003ncw.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat ID4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ID4 (see all 43):
hsa-miR-411* hsa-miR-576-3p hsa-miR-379* hsa-miR-300 hsa-miR-374a hsa-miR-138-2* hsa-miR-342-3p hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidID4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ID4
Predesigned siRNA for gene silencing in human, mouse, rat ID4
Clone
Products:
     
OriGene clones in human, mouse for ID4 (see all 6)
OriGene ORF clones in mouse, rat for ID4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ID4 (NM_001546)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ID4
OriGene qSTAR qPCR primer pairs in human, mouse for ID4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID4
  QuantiTect SYBR Green Assays in human, mouse, rat ID4
  QuantiFast Probe-based Assays in human, mouse, rat ID4

Additional mRNA sequence: 

AJ420553.1 AK130851.1 

5 DOTS entries:

DT.115783  DT.75101421  DT.87002090  DT.121344012  DT.443817 

Selected AceView cDNA sequences (see all 358):

BF058198 AA583355 AA513037 BF434998 BU730086 BM473615 BE669883 BU736386 
BE467572 AV646822 AI268332 AI858674 AI951466 BE219449 BE219820 AI671882 
AA483691 BE671351 BF195477 BI963700 C20741 AI422898 BF446461 AW028722 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

ID4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAATATTAA
ID4 Expression
About this image


ID4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Brain (Nervous System)    fully expand to see all 17 entries
         Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
         Thalamus
         B27-induced oligodendrocyte-like cells
 
 Gonad
         Spermatogonial Stem Cells Seminiferous Tubules
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
 
 Testis (Reproductive System)
         Spermatogonial Stem Cells Seminiferous Tubules
 
 Spinal Cord (Nervous System)    fully expand to see all 3 entries
         Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
         B27-induced oligodendrocyte-like cells
ID4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ID4 Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.519601 Hs.663469
    Pathway & Disease-focused RT2 Profiler PCR Arrays including ID4: 
          Notch Signaling Targets in human mouse rat
          Lymphoma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for ID4
OriGene qSTAR qPCR primer pairs in human, mouse for ID4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID4
QuantiTect SYBR Green Assays in human, mouse, rat ID4
QuantiFast Probe-based Assays in human, mouse, rat ID4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for ID4 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Id41 , 5 inhibitor of DNA binding 41, 5 93.17(n)1
98.14(a)1
  13 (24.71 cM)5
159041  NM_031166.21  NP_112443.11 
 482614275 
chicken
(Gallus gallus)
Aves ID16
DNA-binding protein inhibitor ID-1
21(a)
many ↔ many
20(10351641-10352379)
lizard
(Anolis carolinensis)
Reptilia ID46
inhibitor of DNA binding 4, dominant negative heli...
74(a)
1 ↔ 1
4(56135591-56135893)
African clawed frog
(Xenopus laevis)
Amphibia idb4-prov2 inhibitor of DNA binding 4 78.11(n)    BC045022.1 
zebrafish
(Danio rerio)
Actinopterygii id41 inhibitor of DNA binding 4 66.67(n)
67.2(a)
  664761  NM_001039990.1  NP_001035079.1 
fruit fly
(Drosophila melanogaster)
Insecta emc6
extra macrochaetae
7(a)
1 → many
3L(749400-753492)


ENSEMBL Gene Tree for ID4 (if available)
TreeFam Gene Tree for ID4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for ID4 gene
ID12  ID22  ID32  
3 SIMAP similar genes for ID4 using alignment to 1 protein entry:     ID4_HUMAN:
ID2    ID1    ID3

Find genes that share paralogs with ID4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for ID4 (see all 212)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1146053881,2
C,F--19835631(+) ATCAAT/CGGAAC 1 -- us2k11Minor allele frequency- C:0.03NA 120
rs1822683971,2
--19835696(+) CTCCAA/GGATAA 1 -- us2k10--------
rs1490975641,2
--19835781(+) ATTTAA/GTGATG 1 -- us2k10--------
rs1422147541,2
--19835797(+) GACTAC/TGCCTG 1 -- us2k10--------
rs559077051,2
C,F--19835915(+) CAAACA/CATTAT 1 -- us2k11Minor allele frequency- C:0.05NA 120
rs1859171671,2
--19835948(+) TTAGGG/TGAGAG 1 -- us2k10--------
rs1158860921,2
C,F--19835967(+) TTGCAT/GCTACC 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs69198581,2
C,F,A,H--19836015(+) CAGGAG/AAAAGG 1 -- us2k1 trp39Minor allele frequency- A:0.46NA WA CSA EA 370
rs1467662341,2
C--19836096(+) AGGTAA/TTTCAG 1 -- us2k10--------
rs1402230631,2
--19836117(+) GGATGC/TAGAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ID4 (19837617 - 19840915 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ID4:    About this table    
Variant IDTypeSubtypePubMed ID
esv23665CNV Loss19812545
nsv883465CNV Loss21882294
nsv819869CNV Gain19587683

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ID4
DNA2.0 Custom Variant and Variant Library Synthesis for ID4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 600581    OMIM disorders: --

4 diseases for ID4:    
About MalaCards
oligoastrocytoma    acute leukemia    chronic myeloid leukemia    prostate cancer


Find genes that share disorders with ID4           About GenesLikeMe

9 Novoseek inferred disease relationships for ID4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute 32.5 3 12969807 (1), 17074115 (1), 18928580 (1)
acute leukemia 23.2 1 17074115 (3), 18088456 (2)
leukemia 17.3 10 17074115 (3), 19379587 (2), 12969807 (1), 19099656 (1)
primary tumor 9.31 1 16867866 (1)
prostate cancer 8.42 7 19500415 (6), 16106424 (1)
tumors 6.06 14 19500415 (3), 16867866 (2), 14633621 (2), 16018821 (2) (see all 5)
metastasis 0 2 20388805 (1), 16867866 (1)
carcinoma 0 12 16867866 (7), 14633621 (4)
cancer 0 5 19500415 (2), 16106424 (1)

Genetic Association Database (GAD): ID4
Human Genome Epidemiology (HuGE) Navigator: ID4 (4 documents)

Export disorders for ID4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for ID4 gene, integrated from 10 sources (see all 88):
(articles sorted by number of sources associating them with ID4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PubMed id 7665172)1, 2, 3, 9 Pagliuca A.... Lania L. (Genomics 1995)
  2. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PubMed id 9872455)1, 2, 9 Rigolet M.... Junien C. (DNA Res. 1998)
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (PLoS ONE 2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  6. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. (PubMed id 14633621)1, 9 Shan L....Snyderwine E.G. (Am. J. Pathol. 2003)
  7. [Preliminary study on Id4 as a reporter for all patients before relapse]. (PubMed id 18928580)1, 9 Zhao Y....Yu L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
  8. Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. (PubMed id 12969807)1, 9 Bellido M....NomdedAcu J.F. (Haematologica 2003)
  9. [Preliminary study on difference of Id4 gene methylation in various types of myelodysplastic syndromes]. (PubMed id 19549375)1, 9 Zhao Y....Yu L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
  10. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. (PubMed id 11136250)1, 9 Beger C....Wong-Staal F. (Proc. Natl. Acad. Sci. U.S.A. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 3400 HGNC: 5363 AceView: ID4 Ensembl:ENSG00000172201 euGenes: HUgn3400
ECgene: ID4 Kegg: 3400 H-InvDB: ID4

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for ID4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ID4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for ID4 gene:
Search GeneIP for patents involving ID4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 Browse Kits and Assays available from EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of ID4
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Small Molecules at EMD Millipore
 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for ID4   OriGene RNAi products in human, mouse, rat for ID4  
 OriGene qPCR primer pairs and template standards for ID4   OriGene Protein Over-expression Lysate for ID4  
 OriGene MassSpec for ID4   OriGene clones in human, mouse for ID4  
 OriGene qSTAR qPCR primer pairs in human, mouse for ID4   OriGene Purified Protein for ID4  
 OriGene ORF clones in mouse, rat for ID4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ID4   OriGene Custom Protein Services for ID4  

 
 
 Block miRNA regulation of human, mouse, rat ID4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ID4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ID4 Predesigned siRNA for gene silencing in human, mouse, rat ID4
 QuantiFast Probe-based Assays in human, mouse, rat ID4 QuantiTect SYBR Green Assays in human, mouse, rat ID4
 PCR Arrays including human, mouse, rat ID4 Search Chromatin IP Primers for ID4
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID4  Search GeneGlobe Interaction Network for ID4
 Regulatory tfbs in ID4 promoter
 GenScript Custom Purified and Recombinant Proteins Services for ID4 GenScript cDNA clones with any tag delivered in your preferred vector for ID4
 GenScript Custom Assay Services for ID4 GenScript Custom overexpressing Cell Line Services for ID4
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for ID4
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 ID4 antibodies
 ID4 proteins
 ID4 lysates
 Antibodies for ID4
 See all of Abcam's Antibodies, Kits and Proteins for ID4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for ID4
 Antibodies for ID4
 ELISAs for ID4
 CLIAs for ID4



 Browse ESI BIO Cell Lines and PureStem Progenitors for ID4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID4
 SwitchGear 3'UTR luciferase reporter plasmids for ID4
 SwitchGear Promoter luciferase reporter plasmids for ID4
 ThermoFisher Antibody for ID4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID4
 Browse compounds at ApexBio
 Search Addgene for plasmids for ID4
  Search eBioscience for proteins for ID4
  Search eBioscience for elisas for ID4
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for ID4
 antibodies-online antibodies for ID4 (48 products)
 antibodies-online kits for ID4 (7 products)
 antibodies-online peptides for ID4
 antibodies-online proteins for ID4 (7 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      ID4 gene at Home site.
Version: 3.12.252 27 Nov 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4