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Aliases & Descriptions for ID4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IDB4 2 | | OTTHUMP00000016081 2 | | bHLHb27 1, 2 |
| | | Descriptions |
|---|
| Inhibitor of DNA binding 4 3 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 2 |
|
| | Search outside databases for aliases for ID4 genePrevious GC identifer: GC06P019895 |
Summaries for ID4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ID4: Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM] UniProtKB/Swiss-Prot: ID4_HUMAN, P47928Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA bindingGene Wiki entry for ID4 |
Genomic Location for ID4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ID4 gene 
Entrez Gene cytogenetic band: 6p22-p21 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3ID4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P019945:
(about GC identifiers)
Start:
|
19,945,596 bp from pter |
End:
|
19,948,894 bp from pter |
Size:
|
3,299 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for ID4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ID4_HUMAN, P47928 (See
protein sequence)Recommended Name: DNA-binding protein inhibitor ID-4 Size: 161 amino acids; 16622 Da
Subunit: Heterodimer with other HLH proteins
Subcellular location: Nucleus
Secondary accessions: Q13005REFSEQ proteins: NP_001537.1
ENSEMBL proteins: ENSP00000367972
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: ID4 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for ID4: Assays for ID4: | Protein
Domains/ Families for ID4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P47928
ProtoNet protein and cluster: P47928 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: ID4_HUMAN, P47928Similarity: Contains 1 basic helix-loop-helix (bHLH) domain | Gene Function for ID4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001546
Applied Biosystems Silencer® siRNAs for ID4
Sigma-Aldrich siRNA for ID4  Sigma-Aldrich shRNA for ID4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001546                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001546                                  untagged cDNA clone in CMV expression vector: NM_001546 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001546
UniProtKB/Swiss-Prot: ID4_HUMAN, P47928Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA bindingGenatlas biochemistry entry for ID4:inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly expressed in thyroid,brain and fetal tissue and in some nervous system tumor cell lines5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Id4):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ID4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/16 Interacting proteins for ID4 (P479281 ENSP000003679723) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 7665172 | | GO:0007405 | neuroblast proliferation |
IEA | -- | | GO:0007420 | brain development |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
IEA | -- | About this table
|
Drugs & Compounds for ID4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ID4
|
Transcripts for ID4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001546
Sigma-Aldrich siRNA for ID4  Sigma-Aldrich shRNA for ID4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001546 REFSEQ mRNAs for ID4 gene: NM_001546.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001546               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001546                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001546                                  untagged cDNA clone in CMV expression vector: NM_001546  Additional cDNA sequence: AF085889.1 AJ420553.1 AK130851.1 BC014941.1 U16153.1 U28368.1 Y07958.1 5 DOTS entries: DT.115783 DT.75101421 DT.121344012 DT.87002090 DT.443817 24/358 AceView cDNA sequences (see all 358
):BU743053 AA371177 BF448042 BF058198 F13013 BQ721197 BM703639 AA384132 AA972772 BE467572 AI951466 AA405766 AI887913 AI668810 BM473615 AI671882 BE219449 AW119000 AW297589 BE669883 AW451803 AA454080 BF941891 BU736386
highest scoring ESTs for ID4:AA001053 AA228265 AA230021 AA283186 AA292346 AA332060 AA360044 AA371177 AA384132 AA394164 Unigene Cluster for ID4: Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein Hs.519601 [show with all ESTs]Unigene Representative Sequence: NM_001546
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000378700
|
Expression for ID4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ID4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ID4
1 / 2 / 3 10 probe-sets matching ID4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGAATATTAA
SOURCE GeneReport for Unigene cluster: Hs.519601
Expression variation in blood from EXPOLDB for ID4 |
Orthologs for ID4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ID4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ID4
ENSEMBL Gene Tree for ID4 | Paralogs for ID4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ID4 gene
- ID12 ID22 ID32
|
SNPs/Variants for ID4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ID4 (up to first 250kb)
|
Disorders & Mutations for ID4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600581
8 Novoseek disease relationships for ID4 gene
About this table
|
Medical News for ID4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ID4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/55 PubMed articles for ID4 gene (see all 55
):- Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PubMed id 7665172)1, 2, 3, 4 Pagliuca A.... Lania L. (1995)
- cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PubMed id 9872455)1, 3, 4 Rigolet M.... Junien C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. (PubMed id 14633621)1, 3 Shan L....Snyderwine E.G. (2003)
- Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. (PubMed id 12969807)1, 3 Bellido M....Nomdedeu J.F. (2003)
- Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. (PubMed id 11136250)1, 3 Beger C....Wong-Staal F. (2001)
- Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. (PubMed id 9418957)1, 3 Stewart H.J....Jessen K.R. (1997)
- Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. (PubMed id 18575765)3 Gomez Del Pulgar T....Lacal J.C. (2008)
- Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. (PubMed id 18676808)3 Jeon H.M....Kim H. (2008)
|
Search for ID4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ID4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ID4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ID4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ID4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ID4:

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