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Aliases for ID3 Gene

Aliases for ID3 Gene

  • Inhibitor Of DNA Binding 3, HLH Protein 2 3
  • Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein 2 3 5
  • Inhibitor Of Differentiation 3 2 3 4
  • Class B Basic Helix-Loop-Helix Protein 25 3 4
  • ID-Like Protein Inhibitor HLH 1R21 3 4
  • Helix-Loop-Helix Protein HEIR-1 3 4
  • BHLHb25 3 4
  • Inhibitor Of DNA Binding 3 4
  • HEIR-1 3
  • HEIR1 4
  • 1R21 4

External Ids for ID3 Gene

Previous GeneCards Identifiers for ID3 Gene

  • GC01M023442
  • GC01M022955
  • GC01M023353
  • GC01M023629
  • GC01M023756
  • GC01M023884
  • GC01M022134

Summaries for ID3 Gene

Entrez Gene Summary for ID3 Gene

  • The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID3 Gene

ID3 (Inhibitor Of DNA Binding 3, HLH Protein) is a Protein Coding gene. Diseases associated with ID3 include Fibrodysplasia Ossificans Progressiva. Among its related pathways are NF-kappaB Signaling and TGF-beta signaling pathway (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is ID1.

UniProtKB/Swiss-Prot for ID3 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Wiki entry for ID3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID3 Gene

Genomics for ID3 Gene

Regulatory Elements for ID3 Gene

Enhancers for ID3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ID3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ID3 Gene

Chromosome:
1
Start:
23,557,918 bp from pter
End:
23,559,794 bp from pter
Size:
1,877 bases
Orientation:
Minus strand

Genomic View for ID3 Gene

Genes around ID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID3 Gene

Proteins for ID3 Gene

  • Protein details for ID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02535-ID3_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-3
    Protein Accession:
    Q02535
    Secondary Accessions:
    • A8K1T8
    • O75641

    Protein attributes for ID3 Gene

    Size:
    119 amino acids
    Molecular mass:
    12999 Da
    Quaternary structure:
    • Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation (By similarity). Interacts with CLOCK and ARNTL/BMAL1.
    SequenceCaution:
    • Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ID3 Gene

neXtProt entry for ID3 Gene

Proteomics data for ID3 Gene at MOPED

Post-translational modifications for ID3 Gene

  • Ubiquitination at Lys 30
  • Modification sites at PhosphoSitePlus

Other Protein References for ID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID3 Gene

Domains & Families for ID3 Gene

Gene Families for ID3 Gene

Protein Domains for ID3 Gene

Suggested Antigen Peptide Sequences for ID3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02535

UniProtKB/Swiss-Prot:

ID3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ID3: view

Function for ID3 Gene

Molecular function for ID3 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 3,mouse ld-3 related,expressed during early development and in adult tissues,inhibing transcription factors of the basic helix loop helix family, required for neurogenesis and angiogenesis
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
UniProtKB/Swiss-Prot Induction:
By phorbol 12-myristate 13-acetate (PMA).

Gene Ontology (GO) - Molecular Function for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 20861012
genes like me logo Genes that share ontologies with ID3: view
genes like me logo Genes that share phenotypes with ID3: view

Animal Models for ID3 Gene

MGI Knock Outs for ID3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID3 Gene

Localization for ID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ID3 Gene COMPARTMENTS Subcellular localization image for ID3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
extracellular 2
mitochondrion 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ID3: view

Pathways & Interactions for ID3 Gene

genes like me logo Genes that share pathways with ID3: view

Pathways by source for ID3 Gene

2 Cell Signaling Technology pathways for ID3 Gene
2 BioSystems pathways for ID3 Gene

SIGNOR curated interactions for ID3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001656 metanephros development IEA --
GO:0007417 central nervous system development IEA --
GO:0007507 heart development IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with ID3: view

Drugs & Compounds for ID3 Gene

(2) Drugs for ID3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved Nutra 110

(2) Additional Compounds for ID3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID3: view

Transcripts for ID3 Gene

mRNA/cDNA for ID3 Gene

Unigene Clusters for ID3 Gene

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ID3 Gene

No ASD Table

Relevant External Links for ID3 Gene

GeneLoc Exon Structure for
ID3
ECgene alternative splicing isoforms for
ID3

Expression for ID3 Gene

mRNA expression in normal human tissues for ID3 Gene

Protein differential expression in normal tissues from HIPED for ID3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ID3 Gene



SOURCE GeneReport for Unigene cluster for ID3 Gene Hs.76884

mRNA Expression by UniProt/SwissProt for ID3 Gene

Q02535-ID3_HUMAN
Tissue specificity: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
genes like me logo Genes that share expression patterns with ID3: view

Protein tissue co-expression partners for ID3 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ID3 Gene

Orthologs for ID3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ID3 35
  • 91.6 (n)
  • 97.48 (a)
ID3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ID3 35
  • 92.16 (n)
  • 99.16 (a)
ID3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Id3 35
  • 88.52 (n)
  • 96.64 (a)
Id3 16
Id3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ID3 35
  • 99.44 (n)
  • 99.16 (a)
ID3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Id3 35
  • 87.96 (n)
  • 97.48 (a)
oppossum
(Monodelphis domestica)
Mammalia ID3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID3 35
  • 69.49 (n)
  • 66.95 (a)
ID3 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia id3 35
  • 64.04 (n)
  • 61.4 (a)
zebrafish
(Danio rerio)
Actinopterygii id3 35
  • 60.66 (n)
  • 54.05 (a)
id3 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta emc 36
  • 5 (a)
OneToMany
Species with no ortholog for ID3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID3 Gene

ENSEMBL:
Gene Tree for ID3 (if available)
TreeFam:
Gene Tree for ID3 (if available)

Paralogs for ID3 Gene

Paralogs for ID3 Gene

(3) SIMAP similar genes for ID3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ID3: view

Variants for ID3 Gene

Sequence variations from dbSNP and Humsavar for ID3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_016122 -
VAR_030739 -
rs1018369 -- 23,560,358(+) CCCCC(A/C)CCCAA upstream-variant-2KB
rs1555025 -- 23,560,444(+) ATTGC(G/T)CTATT upstream-variant-2KB
rs1555026 -- 23,560,714(+) AATAG(C/T)TGCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ID3 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV Loss 17160897
nsv871598 CNV Loss 21882294

Variation tolerance for ID3 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ID3 Gene

Human Gene Mutation Database (HGMD)
ID3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID3 Gene

Disorders for ID3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ID3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibrodysplasia ossificans progressiva
  • myositis ossificans progressiva
- elite association - COSMIC cancer census association via MalaCards
Search ID3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ID3

Genetic Association Database (GAD)
ID3
Human Genome Epidemiology (HuGE) Navigator
ID3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ID3
genes like me logo Genes that share disorders with ID3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID3 Gene

Publications for ID3 Gene

  1. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. (PMID: 1628620) Ellmeier W. … Weith A. (EMBO J. 1992) 2 3 4 67
  2. UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3. (PMID: 19054058) Trabosh V.A. … Rosenthal D.S. (Exp. Dermatol. 2009) 3 23
  3. Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via regulation of p21, inhibitor of differentiation genes (Id1-3), and epithelium-mesenchyme transition-like events. (PMID: 19477940) Higgins S. … Russo V.C. (Endocrinology 2009) 3 23
  4. Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells. (PMID: 18281048) Felty Q. … Porther N. (Atherosclerosis 2008) 3 23
  5. Rho/Rho-associated kinase signal regulates myogenic differentiation via myocardin-related transcription factor-A/Smad-dependent transcription of the Id3 gene. (PMID: 18477564) Iwasaki K. … Sobue K. (J. Biol. Chem. 2008) 3 23

Products for ID3 Gene

Sources for ID3 Gene

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