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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ID3 Gene

protein-coding   GIFtS: 63
GCID: GC01M023884

inhibitor of DNA binding 3, dominant negative helix-loop-helix...
 Explore 29 diseases affiliated with
ID3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ID3    

Aliases
for ID3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein1 2     DNA-Binding Protein Inhibitor ID-32
BHLHb251     1R213
HEIR-11 2     BHLHB253
Class B Basic Helix-Loop-Helix Protein 252 3     HEIR13
Helix-Loop-Helix Protein HEIR-12 3     Inhibitor Of DNA Binding 33
ID-Like Protein Inhibitor HLH 1R212 3     

External Ids:    HGNC: 53621   Entrez Gene: 33992   Ensembl: ENSG000001173187   OMIM: 6002775   UniProtKB: Q025353   

Export aliases for ID3 gene to outside databases

Previous GC identifers: GC01M023442 GC01M022955 GC01M023353 GC01M023629 GC01M023756 GC01M022134


Summaries
for ID3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ID3:
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH
proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any
HLH protein with which it interacts. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes
to muscle creatine kinase E-box enhancer. May inhibit other transcription factors

Gene Wiki entry for ID3


Genomic Views
for ID3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ID3 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ID3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ID3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ID3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13-p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.13-p36.12

ID3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023884:  view genomic region     (about GC identifiers)

Start:
 23,884,409 bp from pter      End:
 23,886,322 bp from pter
Size:
 1,914 bases      Orientation:
 minus strand

Proteins
for ID3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-3  
Size: 119 amino acids; 12999 Da
Subunit: Interacts with COPS5 and COPS7A (By similarity). Homodimer, and heterodimer with other HLH proteins
Subcellular location: Nucleus
Sequence caution: Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ID3:
2LFH (3D)    
Secondary accessions: A8K1T8 O75641

Explore the universe of human proteins at neXtProt for ID3: NX_Q02535

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02535

    • ID3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002158.3  
    ENSEMBL proteins: 
     ENSP00000363689  

    Human Recombinant Protein Products: 
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    Novus Biologicals ID3 Proteins
    Novus Biologicals ID3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ID3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    ID3 for ontologies           About GeneDecksing



    ID3 Antibody Products: 
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    Uscn Antibodies for ID3
    ThermoFisher Antibodies for ID3

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    Uscn ELISAs and CLIAs for ID3

    Protein Domains /
    Families
    for ID3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ID3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR026052 DNA-bd_prot-inh
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q02535

    ProtoNet protein and cluster: Q02535

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for ID3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
    with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes
    to muscle creatine kinase E-box enhancer. May inhibit other transcription factors
    Induction: By phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for ID3:
    inhibitor of DNA binding 3,mouse ld-3 related,expressed during early development and in adult tissues,inhibing
    transcription factors of the basic helix loop helix family, required for neurogenesis and angiogenesis

    miRNA
    Products:            		miRTarBase miRNAs that target ID3:
    hsa-mir-520h (MIRT004740)

    OriGene 3'-UTR Clone: ID3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ID3 (see all 16):
    hsa-miR-3193 hsa-miR-340 hsa-miR-1180 hsa-miR-515-5p hsa-miR-548m hsa-miR-1910 hsa-miR-3163 hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmid: ID3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID3 (see all 7)
    OriGene shRNA RFP: ID3
    OriGene siRNA: ID3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ID3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID3 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ID3 (NM_005224)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID3 

    Cell Line
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    LifeMap BioReagents: cell line associated with ID3: PureStem ES-210, Ecto-ntu Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8437843
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IEA--
    GO:0019904protein domain specific binding IEA--


    ID3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ID3:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-outs for ID3: Id3tm1Zhu Id3tm1Cmu
         15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Id3):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  immune system  mortality/aging  nervous system 
     normal  reproductive system  skeleton  tumorigenesis  vision/eye 

    ID3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ID3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta/Smad Signaling
    		TGF-beta/Smad Signaling1.00
    2Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    3Id Signaling Pathway
    		Id Signaling Pathway1.00
    4Adipogenesis
    		Adipogenesis1.00
    5TGF-beta signaling pathway
    		TGF-beta signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ID3
        Lymphocyte Signaling
    TGF-beta/Smad Signaling

    2 BioSystems Pathways for ID3 
        Adipogenesis
    Id Signaling Pathway


    1         Kegg Pathway  (Kegg details for ID3):
        TGF-beta signaling pathway


    ID3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ID3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for ID3 (Q025353 ENSP000003636894) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=3 STRING: ENSP00000250003
    TCF12Q990813, ENSP000003310574I2D: score=3 STRING: ENSP00000331057
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    IFI16Q166663, ENSP000003571134I2D: score=2 STRING: ENSP00000357113
    CNOT3O751753, ENSP000002212324I2D: score=1 STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001656metanephros development IEA--
    GO:0006275regulation of DNA replication IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS1628620


    ID3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ID3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ID3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ID3

    1 HMDB Compound for ID3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    3 Novoseek chemical compound relationships for ID3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 10.5 1 10575541 (1)
    vegf 9.72 4 15494533 (2), 19180920 (2)
    oxygen 0 2 19054058 (2)

    Search CenterWatch for drugs/clinical trials and news about ID3 

    Transcripts
    for ID3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ID3 gene: 
    NM_002167.4  

    Unigene Cluster for ID3:

    Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
    Hs.76884  [show with all ESTs]
    Unigene Representative Sequence: AK225965
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374561(uc001bhh.4) ENST00000463312 ENST00000486541

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ID3 (see all 16):
    hsa-miR-3193 hsa-miR-340 hsa-miR-1180 hsa-miR-515-5p hsa-miR-548m hsa-miR-1910 hsa-miR-3163 hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmid: ID3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID3 (see all 7)
    OriGene shRNA RFP: ID3
    OriGene siRNA: ID3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID3
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    GenScript: all cDNA clones in your preferred vector: ID3 (NM_005224)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID3
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID3

    Additional cDNA sequence: 

    AK225965.1 AK290003.1 BC003107.1 BT006791.1 D28449.1 X66924.1 X69111.1 

    10 DOTS entries:

    DT.448517  DT.92452265  DT.100817038  DT.100817039  DT.97855621  DT.95365730  DT.95365717  DT.121403793 
    DT.92452272  DT.95099597 

    24/562 AceView cDNA sequences (see all 562):

    AI332892 CA420836 AA425764 BQ014563 BF061101 D28449 BE221233 AI077534 
    CR603067 CR623483 AA583583 BE277021 BQ005231 AA987439 BM739497 BM739564 
    CR611504 BE394426 BF437237 N50460 CR620515 CR614670 H89353 CD671237 

    GeneLoc Exon Structure


    Expression
    for ID3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ID3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCACTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ID3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    KidneyCap MesenchymeKidney
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage
    HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone

    See ID3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ID3

    SOURCE GeneReport for Unigene cluster: Hs.76884

    UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
    Tissue specificity: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ID3: 
              Notch Signaling Targets in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID3

    Orthologs
    for ID3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ID3 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ID31 inhibitor of DNA binding 3, dominant negative helix-loop-helix more 69.49(n)
    66.95(a)    		   395281  NM_204589.1  NP_989920.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1419910252   -- 74.41(n)    141991025 
    zebrafish
    (Danio rerio)    		 Actinopterygii id31 inhibitor of DNA binding 3 64.98(n)
    64.56(a)    		   246093  NM_152967.1  NP_694499.1 


    ENSEMBL Gene Tree for ID3 (if available)
    TreeFam Gene Tree for ID3 (if available) 

    Paralogs
    for ID3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ID3 gene
    ID12  ID22  ID42  
    3 SIMAP similar genes for ID3 using alignment to 1 protein entry:     ID3_HUMAN:
    ID1    ID2    ID4

    ID3 for paralogs           About GeneDecksing



    Genomic Variants
    for ID3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 NCBI SNPs in ID3 are shown (see all 135)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425440231,2
    		--23883953(+) TCATTC/TTTGGA 1 -- ds50010--------
    rs740627401,2
    		C,--23883961(+) GGAATT/CGGTCT 1 -- ds50012Minor allele frequency- C:0.06WA 120
    rs1908046861,2
    		--23883967(+) GGTCTA/GTCAAC 1 -- ds50010--------
    rs1840482301,2
    		--23884013(+) TGAGGC/GTCTCC 1 -- ds50010--------
    rs745253931,2
    		F,--23884172(+) AAGCTT/CGCACC 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs725087451,2
    		C,--23884205(+) AATGAG/-GCAGA 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs114439921,2
    		C--23884207(+) ATGAGG/-CAGAG 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1460085171,2
    		--23884222(+) GAACTC/TTTCTC 1 -- ds50010--------
    rs1399555501,2
    		--23884239(+) CATCCC/TTCAAT 1 -- ds50010--------
    rs1422269871,2
    		--23884285(+) CACCCA/CATCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ID3 (23884409 - 23886322 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ID3: --
    Human Gene Mutation Database (HGMD): ID3

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    Disorders / Diseases
    for ID3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ID3 for disorders           About GeneDecksing

    OMIM gene information: 600277    OMIM disorders: --

    20/29 diseases for ID3 (see all 29):    About MalaCards
    fibrodysplasia ossificans progressiva    rett syndrome    burkitt's lymphoma    sjogren's syndrome
    lupus erythematosus    pituitary tumor    embryonal carcinoma    rheumatoid arthritis
    thyroid cancer    gastric adenocarcinoma    adenocarcinoma    lung adenocarcinoma
    thyroiditis    hematopoiesis    hepatocellular carcinoma    arthritis
    gastric cancer    peritonitis    pancreatic cancer    lung cancer

    7 Novoseek disease relationships for ID3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid cancer 23.1 3 16394085 (2)
    leukemia t-cell 21.2 2 8632670 (2)
    tumors 15.5 14 18069898 (2), 16394085 (2), 15342397 (2), 18048329 (1) (see all 7)
    lymphoma 12.3 2 15780199 (1), 8632670 (1)
    retinoblastoma 5.26 2 12021231 (2)
    adenocarcinoma 0 4 11751402 (2), 11161400 (1)
    metastasis 0 1 15342397 (1)

    Genetic Association Database (GAD): ID3
    Human Genome Epidemiology (HuGE) Navigator: ID3 (6 documents)

    Export disorders for ID3 gene to outside databases

    Publications
    for ID3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ID3 gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with ID3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. (PubMed id 1628620)1, 2, 3 Ellmeier W.... Weith A. (1992)
    2. Structural organisation and chromosomal mapping of the human Id-3 gene. (PubMed id 7828896)1, 2, 9 Deed R.W....Norton J.D. (1994)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4 Burmester J.K....Catalona W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. (PubMed id 8437843)1, 2 Deed R.W.... Norton J.D. (1993)
    7. UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3. (PubMed id 19054058)1, 9 Trabosh V.A....Rosenthal D.S. (2009)
    8. Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome. (PubMed id 15451666)1, 9 Berse M....Dubiel W. (2004)
    9. Expression of Id2 and Id3 mRNA in human lymphocytes. (PubMed id 8632670)1, 9 Ishiguro A....Koeffler H.P. (1995)
    10. Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells. (PubMed id 18281048)1, 9 Felty Q. and Porther N. (2008)

    External Searches for ID3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ID3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3399 HGNC: 5362 AceView: ID3 Ensembl:ENSG00000117318 euGenes: HUgn3399
    ECgene: ID3 Kegg: 3399 H-InvDB: ID3

    Other Databases showing ID3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ID3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ID3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ID3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ID3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ID3 gene:
    Search GeneIP for patents involving ID3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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