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ID3 Gene

protein-coding   GIFtS: 65
GCID: GC01M023884

Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix...

  Search for ID3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix
Protein1 2
     DNA-Binding Protein Inhibitor ID-32
Class B Basic Helix-Loop-Helix Protein 252 3     1R213
Helix-Loop-Helix Protein HEIR-12 3     BHLHB253
bHLHb252 3     HEIR13
ID-Like Protein Inhibitor HLH 1R212 3     Inhibitor Of DNA Binding 33
HEIR-12     

External Ids:    HGNC: 53621   Entrez Gene: 33992   Ensembl: ENSG000001173187   OMIM: 6002775   UniProtKB: Q025353   

Export aliases for ID3 gene to outside databases

Previous GC identifers: GC01M023442 GC01M022955 GC01M023353 GC01M023629 GC01M023756 GC01M022134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ID3 Gene:
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH
proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of
any HLH protein with which it interacts. (provided by RefSeq, Aug 2011)

GeneCards Summary for ID3 Gene:
ID3 (inhibitor of DNA binding 3, dominant negative helix-loop-helix protein) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ID1.

UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting
skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits
the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other
transcription factors

Gene Wiki entry for ID3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ID3 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidID3 promoter sequence
   Search Chromatin IP Primers for ID3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ID3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13-p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.13-p36.12

ID3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023884:  view genomic region     (about GC identifiers)

Start:
23,884,409 bp from pter      End:
23,886,322 bp from pter
Size:
1,914 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-3  
Size: 119 amino acids; 12999 Da
Subunit: Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with
IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast
differentiation (By similarity)
Sequence caution: Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ID3:
2LFH (3D)    
Secondary accessions: A8K1T8 O75641

Explore the universe of human proteins at neXtProt for ID3: NX_Q02535

Explore proteomics data for ID3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30
  • Modification sites at PhosphoSitePlus

  • See ID3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002158.3  
    ENSEMBL proteins: 
     ENSP00000363689  

    ID3 Human Recombinant Protein Products:

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    Novus Biologicals ID3 Proteins
    Novus Biologicals ID3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ID3

     
    Search eBioscience for Proteins for ID3 

    ID3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ID3
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    LSBio Antibodies in human, mouse, rat for ID3

    ID3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ID3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ID3
    Cloud-Clone Corp. CLIAs for ID3
    Search eBioscience for ELISAs for ID3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR026052 DNA-bd_prot-inh
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q02535

    ProtoNet protein and cluster: Q02535

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with ID3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ID3_HUMAN, Q02535
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
    heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting
    skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits
    the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other
    transcription factors
    Induction: By phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for ID3:
    inhibitor of DNA binding 3,mouse ld-3 related,expressed during early development and in adult tissues,inhibing
    transcription factors of the basic helix loop helix family, required for neurogenesis and angiogenesis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8437843
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with ID3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ID3:
     Decreased viability with pacli 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Id3):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  mortality/aging  nervous system 
     normal  reproductive system  skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with ID3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ID3: Id3tm1Zhu Id3tm1Cmu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ID3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ID3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ID3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ID3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ID3:
    hsa-mir-124-3p (MIRT022266), hsa-mir-520h (MIRT004740)

    Block miRNA regulation of human, mouse, rat ID3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ID3 (see all 16):
    hsa-miR-3193 hsa-miR-340 hsa-miR-1180 hsa-miR-515-5p hsa-miR-548m hsa-miR-1910 hsa-miR-3163 hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmidID3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ID3
    Predesigned siRNA for gene silencing in human, mouse, rat ID3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ID3

    Clone
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    OriGene ORF clones in mouse, rat for ID3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ID3 (NM_005224)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID3
    Addgene plasmids for ID3 

    Cell Line
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    ESI BIO PureStem Progenitor for ID3: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13126) for ID3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ID3_HUMAN, Q02535: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion3
    cytosol2
    extracellular2
    plasma membrane2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with ID3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ID3 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta/Smad Signaling
    TGF-beta/Smad Signaling
    2TGF-beta signaling pathway (KEGG)
    TGF-beta signaling pathway
    3Lymphocyte Signaling
    Lymphocyte Signaling
    4Id Signaling Pathway
    Id Signaling Pathway
    5Adipogenesis
    Adipogenesis


    Find genes that share SuperPaths with ID3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ID3
        Lymphocyte Signaling
    TGF-beta/Smad Signaling

    2 BioSystems Pathways for ID3
        Adipogenesis
    Id Signaling Pathway


    1 Kegg Pathway  (Kegg details for ID3):
        TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID3: 
              Notch Signaling Targets in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ID3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ID3 (Q025353 ENSP000003636894) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=3 STRING: ENSP00000250003
    TCF12Q990813, ENSP000003310574I2D: score=3 STRING: ENSP00000331057
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    IFI16Q166663, ENSP000003571134I2D: score=2 STRING: ENSP00000357113
    CNOT3O751753, ENSP000002212324I2D: score=1 STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001656metanephros development IEA--
    GO:0006275regulation of DNA replication IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development TAS1628620

    Find genes that share ontologies with ID3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ID3

    1 HMDB Compound for ID3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--

    3 Novoseek inferred chemical compound relationships for ID3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 10.5 1 10575541 (1)
    vegf 9.72 4 15494533 (2), 19180920 (2)
    oxygen 0 2 19054058 (2)



    Find genes that share compounds with ID3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ID3 gene: 
    NM_002167.4  

    Unigene Cluster for ID3:

    Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
    Hs.76884  [show with all ESTs]
    Unigene Representative Sequence: AK225965
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374561(uc001bhh.4) ENST00000463312 ENST00000486541
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ID3 (see all 16):
    hsa-miR-3193 hsa-miR-340 hsa-miR-1180 hsa-miR-515-5p hsa-miR-548m hsa-miR-1910 hsa-miR-3163 hsa-miR-224
    SwitchGear 3'UTR luciferase reporter plasmidID3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: ID3 (NM_005224)
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    Addgene plasmids for ID3 
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    OriGene qSTAR qPCR primer pairs in human, mouse for ID3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID3
      QuantiTect SYBR Green Assays in human, mouse, rat ID3
      QuantiFast Probe-based Assays in human, mouse, rat ID3
    Flow Cytometry
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    Additional mRNA sequence: 

    AK225965.1 AK290003.1 BC003107.1 BT006791.1 D28449.1 X66924.1 X69111.1 

    10 DOTS entries:

    DT.448517  DT.92452265  DT.100817038  DT.100817039  DT.97855621  DT.95365730  DT.95365717  DT.121403793 
    DT.92452272  DT.95099597 

    Selected AceView cDNA sequences (see all 562):

    BQ005231 CR623483 AA425764 CR611504 BQ014563 CR612668 AI077534 AA583583 
    BF437237 CR597388 D28449 N50460 BF339353 AI949079 AI332892 CA420836 
    BQ008635 BF061101 H89353 BM739497 CR614670 BE221233 BM739564 BF439510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ID3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACTGCT
    ID3 Expression
    About this image


    ID3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 14 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Lateral Ventricle
             Midbrain dopaminergic-like neurons
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Cap Mesenchyme Cells Cap Mesenchyme
             Interstitial Stroma
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
    ID3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ID3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76884

    UniProtKB/Swiss-Prot: ID3_HUMAN, Q02535
    Tissue specificity: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID3: 
              Notch Signaling Targets in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ID3
    OriGene qSTAR qPCR primer pairs in human, mouse for ID3
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    QuantiFast Probe-based Assays in human, mouse, rat ID3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ID3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Id31 , 5 inhibitor of DNA binding 31, 5 88.52(n)1
    96.64(a)1
      4 (68.34 cM)5
    159031  NM_008321.21  NP_032347.11 
     1361434975 
    chicken
    (Gallus gallus)
    Aves ID31 inhibitor of DNA binding 3, dominant negative helix-loop-helix more 69.49(n)
    66.95(a)
      395281  NM_204589.1  NP_989920.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1419910252   -- 74.41(n)    141991025 
    zebrafish
    (Danio rerio)
    Actinopterygii id31 inhibitor of DNA binding 3 60.66(n)
    54.05(a)
      246093  NM_152967.1  NP_694499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta emc6
    extra macrochaetae
    5(a)
    1 → many
    3L(749400-753492)


    ENSEMBL Gene Tree for ID3 (if available)
    TreeFam Gene Tree for ID3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ID3 gene
    ID12  ID22  ID42  
    3 SIMAP similar genes for ID3 using alignment to 1 protein entry:     ID3_HUMAN:
    ID1    ID2    ID4

    Find genes that share paralogs with ID3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ID3 (see all 171)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425440231,2
    --23883953(+) TCATTC/TTTGGA 1 -- ds50010--------
    rs740627401,2
    C,F--23883961(+) GGAATT/CGGTCT 1 -- ds50012Minor allele frequency- C:0.06WA 120
    rs1908046861,2
    --23883967(+) GGTCTA/GTCAAC 1 -- ds50010--------
    rs1840482301,2
    --23884013(+) TGAGGC/GTCTCC 1 -- ds50010--------
    rs745253931,2
    F--23884172(+) AAGCTT/CGCACC 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1460085171,2
    --23884222(+) GAACTC/TTTCTC 1 -- ds50010--------
    rs1399555501,2
    --23884239(+) CATCCC/TTCAAT 1 -- ds50010--------
    rs1422269871,2
    --23884285(+) CACCCA/CATCCC 1 -- ds50010--------
    rs1888813731,2
    --23884309(+) AGTTTC/TTCATT 1 -- ds50010--------
    rs20714951,2
    C,F,O,H--23884333(-) AACTTG/CCTTAT 1 -- ds500118Minor allele frequency- C:0.27NS EA NA 1400

    HapMap Linkage Disequilibrium report for ID3 (23884409 - 23886322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ID3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871598CNV Loss21882294
    nsv834435CNV Loss17160897

    Human Gene Mutation Database (HGMD): ID3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ID3
    DNA2.0 Custom Variant and Variant Library Synthesis for ID3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600277    OMIM disorders: --


    Find genes that share disorders with ID3           About GenesLikeMe

    7 Novoseek inferred disease relationships for ID3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid cancer 23.1 3 16394085 (2)
    leukemia t-cell 21.2 2 8632670 (2)
    tumors 15.5 14 18069898 (2), 16394085 (2), 15342397 (2), 18048329 (1) (see all 7)
    lymphoma 12.3 2 15780199 (1), 8632670 (1)
    retinoblastoma 5.26 2 12021231 (2)
    adenocarcinoma 0 4 11751402 (2), 11161400 (1)
    metastasis 0 1 15342397 (1)

    Genetic Association Database (GAD): ID3
    Human Genome Epidemiology (HuGE) Navigator: ID3 (6 documents)

    Export disorders for ID3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ID3 gene, integrated from 10 sources (see all 173):
    (articles sorted by number of sources associating them with ID3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. (PubMed id 1628620)1, 2, 3 Ellmeier W.... Weith A. (EMBO J. 1992)
    2. Structural organisation and chromosomal mapping of the human Id-3 gene. (PubMed id 7828896)1, 2, 9 Deed R.W....Norton J.D. (Gene 1994)
    3. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. (PubMed id 20185798)1, 4 Doran A.C....McNamara C.A. (Circ. Res. 2010)
    4. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    5. Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer. (PubMed id 18374504)1, 4 Suga T....Imai T. (Int. J. Radiat. Oncol. Biol. Phys. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4 Burmester J.K....Catalona W.J. (Hum. Hered. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. (PubMed id 8437843)1, 2 Deed R.W.... Norton J.D. (Oncogene 1993)
    10. UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3. (PubMed id 19054058)1, 9 Trabosh V.A....Rosenthal D.S. (Exp. Dermatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3399 HGNC: 5362 AceView: ID3 Ensembl:ENSG00000117318 euGenes: HUgn3399
    ECgene: ID3 Kegg: 3399 H-InvDB: ID3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ID3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ID3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ID3 gene:
    Search GeneIP for patents involving ID3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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