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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ID2 Gene

protein-coding   GIFtS: 60
GCID: GC02P008818

inhibitor of DNA binding 2, dominant negative helix-loop-helix...
 Explore 40 diseases affiliated with
ID2 via
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Biological research products
for ID2    

Aliases
for ID2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein1 2     DNA-Binding Protein Inhibitor ID-22
BHLHb261     DNA-Binding Protein Inhibitor ID22
GIG81 2     Helix-Loop-Helix Protein ID22
Class B Basic Helix-Loop-Helix Protein 262 3     Inhibitor Of Differentiation 22
ID2A2     BHLHB263
ID2H2     Inhibitor Of DNA Binding 23
Cell Growth-Inhibiting Gene 82     

External Ids:    HGNC: 53611   Entrez Gene: 33982   Ensembl: ENSG000001157387   OMIM: 6003865   UniProtKB: Q023633   

Export aliases for ID2 gene to outside databases

Previous GC identifers: GC02P008605 GC02P008873 GC02P008843 GC02P008772


Summaries
for ID2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ID2:
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional
regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA
binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by
suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively
regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression

Gene Wiki entry for ID2


Genomic Views
for ID2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ID2 gene promoter:
         IRF-2   p53   SREBP-1c   FOXO4   Egr-1   Nkx2-5   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ID2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ID2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P008818:  view genomic region     (about GC identifiers)

Start:
 8,818,975 bp from pter      End:
 8,824,583 bp from pter
Size:
 5,609 bases      Orientation:
 plus strand

Proteins
for ID2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-2  
Size: 134 amino acids; 14917 Da
Subunit: Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with
NR0B2
Subcellular location: Cytoplasm (By similarity). Nucleus
Developmental stage: Found in most early fetal tissues but not in the corresponding mature tissues
1 PDB 3D structure from and Proteopedia for ID2:
4AYA (3D)    

Explore the universe of human proteins at neXtProt for ID2: NX_Q02363

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02363

    • ID2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002157.2  
    ENSEMBL proteins: 
     ENSP00000234091   ENSP00000385465   ENSP00000379585  

    Human Recombinant Protein Products: 
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    Novus Biologicals ID2 Proteins
    Novus Biologicals ID2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ID2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737colocalizes with cytoplasm IDA16311606
    GO:0005829cytosol IDA16311606


    ID2 for ontologies           About GeneDecksing



    ID2 Antibody Products: 
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    Uscn Antibodies for ID2
    ThermoFisher Antibodies for ID2

    Assay Products for ID2: 
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    GenScript Custom Assay Services for ID2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ID2

    Protein Domains /
    Families
    for ID2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ID2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR026052 DNA-bd_prot-inh
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q02363

    ProtoNet protein and cluster: Q02363

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for ID2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
    with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression

         Genatlas biochemistry entry for ID2:
    inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription
    factors of the basic helix loop helix family

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID2
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ID2 (see all 20):
    hsa-miR-4311 hsa-miR-300 hsa-miR-340 hsa-miR-583 hsa-miR-1276 hsa-miR-298 hsa-miR-330-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ID2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID2 (see all 7)
    OriGene shRNA RFP: ID2
    OriGene siRNA: ID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ID2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ID2 (NM_001510)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ID2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ID2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10915743
    GO:0030528transcription regulator activity ----
    GO:0044325ion channel binding IPI16311606
    GO:0046983protein dimerization activity IEA--


    ID2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ID2:
     Cell cycle / mitosis defect  Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for ID2: Id2tm1Jdu Id2tm1Yyk Id2tm1Mcha Id2tm1Ago
         15/16 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Id2) (see all 16):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  immune system  integument  mortality/aging 
     nervous system  no phenotypic analysis  renal/urinary system  reproductive system  taste/olfaction 

    ID2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ID2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    2Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    3Selected targets of C/EBPbeta
    		Selected targets of C/EBPbeta1.00
    4Selected targets of CREB1
    		Selected targets of CREB11.00
    5miRs in Muscle Cell Differentiation
    		miRs in Muscle Cell Differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ID2
        Selected targets of C/EBPbeta
    Selected targets of Oct-3/4
    Selected targets of CREB1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ID2
        Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for ID2
        Wnt / Hedgehog / Notch

    5/6 BioSystems Pathways for ID2 (see all 6) 
        Id Signaling Pathway
    Validated targets of C-MYC transcriptional repression
    miRs in Muscle Cell Differentiation
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Validated targets of C-MYC transcriptional activation


    1         Kegg Pathway  (Kegg details for ID2):
        TGF-beta signaling pathway


    ID2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for ID2 (Q023631, 2, 3 ENSP000002340914) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-64029 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-64030 I2D: score=4 
    CCNDBP1O952732MINT-8396328 MINT-8396313 MINT-8396281 MINT-8396356
    TCF3P15923-11, ENSP000002629654EBI-713450,EBI-769645 I2D: score=5 STRING: ENSP00000262965
    MYOD1P151723, ENSP000002500034I2D: score=3 STRING: ENSP00000250003
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001656metanephros development IEA--
    GO:0001779natural killer cell differentiation IEA--
    GO:0002521leukocyte differentiation ----
    GO:0003166bundle of His development IEA--


    ID2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ID2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ID2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ID2
    9 Novoseek chemical compound relationships for ID2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 21.4 9 19260835 (2), 15831462 (2), 17393418 (1), 19180920 (1)
    phosphatidylinositol 11.1 1 16150928 (1)
    bromodeoxyuridine 9.61 1 19609365 (1)
    oligonucleotide 9.04 1 12670915 (1)
    retinoic acid 8.53 7 17310985 (2), 16549780 (1), 14582708 (1)
    butyrate 7.36 1 10330158 (1)
    calcitriol 5.17 1 16007183 (1)
    estrogen 0 2 15809228 (1), 19257909 (1)
    dexamethasone 0 3 11317672 (2), 12424200 (1)

    Search CenterWatch for drugs/clinical trials and news about ID2 

    Transcripts
    for ID2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ID2 gene: 
    NM_002166.4  

    Unigene Clusters for ID2:

    Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
    Hs.180919  [show with all ESTs], Hs.726053  [show with all ESTs]
    Unigene Representative Sequences: NM_002166, BM808036
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234091(uc002qza.3) ENST00000331129 ENST00000472142 ENST00000396290


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID2
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ID2 (see all 20):
    hsa-miR-4311 hsa-miR-300 hsa-miR-340 hsa-miR-583 hsa-miR-1276 hsa-miR-298 hsa-miR-330-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ID2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID2 (see all 7)
    OriGene shRNA RFP: ID2
    OriGene siRNA: ID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ID2
    Clone
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    GenScript: all cDNA clones in your preferred vector: ID2 (NM_001510)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ID2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID2

    Additional cDNA sequence: 

    AK311988.1 AY634687.1 

    18 DOTS entries:

    DT.102824856  DT.92437989  DT.100818571  DT.100818572  DT.100818580  DT.100818582  DT.419995  DT.100722779 
    DT.95334744  DT.100818570  DT.92437995  DT.100697819  DT.100818576  DT.102843630  DT.120992816  DT.120992827 
    DT.92437991  DT.91990899 

    24/483 AceView cDNA sequences (see all 483):

    BP380292 CR623038 BM763133 AV706301 CB107753 AI686940 BI962513 AI129437 
    AU076888 AA593780 BQ269932 AA033992 BM782333 CR614653 CR611001 BM477782 
    AI275903 AI346160 AI051907 AA889009 AI281085 BE884626 AI355196 CA436687 

    GeneLoc Exon Structure


    Expression
    for ID2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGAAGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ID2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudDistal Lung Progenitor CellsLung
    Extraembryonic MesodermExtraembryonic MesodermExtraembryonic Mural CellsExtraembryonic Tissues
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    Lateral Plate MesodermSplanchnic MesodermMural CellsPericytes, Smooth Muscle
    LungTerminal SacsAlveolar Progenitor CellsLung
    LungTerminal SacsDistal Lung Epithelial CellsLung
    Neural CrestCranial Neural CrestCranial Neural Crest CellsNeural Crest
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    OvaryAntral FollicleMature Granulosa CellsOvary
    HeartAtrioventricular CanalHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Endoderm progenitor-like cells (Generation and expan...)
    Nkx2-1 GFP+ cells (Efficient derivation...)
    Trophoblast-like cells (Generation of tropho...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See ID2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ID2

    SOURCE GeneReport for Unigene clusters: Hs.180919 Hs.726053

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system

        SABiosciences Expression via Pathway-Focused PCR Arrays including ID2: 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID2
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ID2

    Orthologs
    for ID2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ID2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ID21 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein less 86.32(n)
    94.03(a)    		   395852  NM_205002.1  NP_990333.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ID26
    		 --
    		 85(a)
    		 1 ↔ 1
    		 1(148975147-148976938)
    African clawed frog
    (Xenopus laevis)    		 Amphibia id22 Id2 protein 81.46(n)    BC041527.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii id22 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein less 78.85(n)   266599  AY398363.1 


    ENSEMBL Gene Tree for ID2 (if available)
    TreeFam Gene Tree for ID2 (if available) 

    Paralogs
    for ID2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ID2 gene
    ID12  ID32  ID42  
    4 SIMAP similar genes for ID2 using alignment to 2 protein entries:     ID2_HUMAN (see all proteins):
    ID2B    ID4    ID1    ID3

    ID2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ID2
    PGOHUM00000250241


    Genomic Variants
    for ID2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 NCBI SNPs in ID2 are shown (see all 124)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs731470961,2
    		C,--8666403(+) ATGCAC/AACAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs757764901,2
    		F,--8666483(+) GATACG/AGTGCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs118856001,2
    		C,F,A,H,--8666488(+) GGTGCA/GTCCAA 1 -- us2k110Minor allele frequency- G:0.10NS EA NA WA 842
    rs124686011,2
    		H--8666516(+) TCGCAA/GGCAGC 1 -- us2k10--------
    rs13179661,2
    		C,A,--8820446(-) TTCCCC/TAGGCC 3 -- nc-transcript-variantus2k11Minor allele frequency- T:0.00MN 184
    rs22417401,2
    		C,F,H,--8820584(+) TGGGGC/AGCATA 2 -- us2k1 nc-transcript-variant8Minor allele frequency- A:0.20EA NS NA 1746
    rs1823806361,2
    		--8820588(+) GCGCAG/TAGCTG 2 -- us2k1 nc-transcript-variant0--------
    rs1431601831,2
    		--8820603(+) GTGACA/GGTCAG 2 -- nc-transcript-variantus2k10--------
    rs1387570921,2
    		--8820604(+) TGACGA/GTCAGA 2 -- nc-transcript-variantus2k10--------
    rs1418966861,2
    		--8820615(+) GACTGC/GTGGCC 2 -- nc-transcript-variantus2k10--------

    HapMap Linkage Disequilibrium report for ID2 (8818975 - 8824583 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ID2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ID2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ID2 for disorders           About GeneDecksing

    OMIM gene information: 600386    OMIM disorders: --

    20/40 diseases for ID2 (see all 40):    About MalaCards
    diamond-blackfan anemia    anaplastic large cell lymphoma    liver cirrhosis    acute promyelocytic leukemia
    ewing's family of tumors    hydronephrosis    rett syndrome    monocytic leukemia
    kaposi's sarcoma    squamous cell carcinoma    hodgkin's lymphoma    colon carcinoma
    embryonal carcinoma    prostate cancer, progression of    protein s deficiency    retinoblastoma
    sarcoma    osteosarcoma    prostate cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ID2:
    Retinoblastoma

    10/15 Novoseek disease relationships for ID2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 56.4 13 11034201 (2), 15831462 (1), 16733829 (1), 16549780 (1) (see all 10)
    ewings sarcoma 41.7 10 16869242 (7), 12527902 (3)
    tumors 38.2 45 20388805 (5), 12545167 (3), 16549780 (3), 12447693 (2) (see all 24)
    cancer 12.2 7 12447693 (1), 16733829 (1), 9731481 (1), 18413820 (1) (see all 6)
    lymphoma 10.4 7 15492249 (2), 18085637 (1), 8632670 (1)
    colon carcinoma 3.22 5 11572874 (2), 16007183 (1)
    leukemia 0 2 8632670 (1), 15492249 (1)
    primary tumor 0 1 12447693 (1)
    glioma 0 2 7622574 (1), 12007145 (1)
    hypertrophy 0 2 16002773 (1), 15601750 (1)

    Human Genome Epidemiology (HuGE) Navigator: ID2 (6 documents)

    Export disorders for ID2 gene to outside databases

    Publications
    for ID2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ID2 gene, integrated from 9 sources (see all 225):
    (articles sorted by number of sources associating them with ID2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)1, 2, 3 Hara E....Oda K. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A human Id-like helix-loop-helix protein expressed during early development. (PubMed id 1741406)1, 2 Biggs J.... Israel M.A. (1992)
    4. Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. (PubMed id 19257909)1, 9 Meng Y....Han W. (2009)
    5. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. (PubMed id 19010462)1, 9 Weigent D.A. (2009)
    6. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. (PubMed id 16776654)1, 9 Rodriguez J.L....Torres L. (2006)
    7. The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas. (PubMed id 18085637)1, 9 Cotta C.V....Rassidakis G.Z. (2008)
    8. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. (PubMed id 16549780)1, 9 Lasorella A. and Iavarone A. (2006)
    9. Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. (PubMed id 15252039)1, 9 Lofstedt T....Axelson H. (2004)
    10. FHL2 interacts with and acts as a functional represso r of Id2 in human neuroblastoma cells. (PubMed id 19417068)1, 9 Han W....Yu L. (2009)

    External Searches for ID2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ID2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3398 HGNC: 5361 AceView: ID2 Ensembl:ENSG00000115738 euGenes: HUgn3398
    ECgene: ID2 Kegg: 3398 H-InvDB: ID2

    Other Databases showing ID2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ID2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ID2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ID2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ID2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ID2 gene:
    Search GeneIP for patents involving ID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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